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Ligand source activities (1 row/activity)

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	155146067	184024	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	184024	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155154170	184165	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184165	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155146047	186015	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	186015	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	3238641	31190	35	None	354	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL1402510	31190	35	None	354	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	2566134	68771	10	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	5.0	O=C(O)c1cccc(CSc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL1923999	68771	10	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	5.0	O=C(O)c1cccc(CSc2ccc(Cl)cc2Cl)c1	nan
	584653	183836	41	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2ccc(Br)cc2)c1	nan
	CHEMBL4846114	183836	41	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2ccc(Br)cc2)c1	nan
	155153910	183841	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	4.8	O=C(O)c1cccc(COc2cc3ccccc3cc2Cl)c1	nan
	CHEMBL4846170	183841	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	4.8	O=C(O)c1cccc(COc2cc3ccccc3cc2Cl)c1	nan
	155145976	183874	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ncc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4846676	183874	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ncc(C(F)(F)F)cc2Cl)c1	nan
	155154008	183892	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	368	5	1	3	4.2	N#CCNC(=O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	CHEMBL4846959	183892	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	368	5	1	3	4.2	N#CCNC(=O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	155154202	183907	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	407	5	1	4	3.6	CS(=O)(=O)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4847181	183907	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	407	5	1	4	3.6	CS(=O)(=O)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153982	183917	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	5	1	2	4.5	O=C(O)c1cccc(COc2ccc(C3CC3)cc2Cl)c1	nan
	CHEMBL4847374	183917	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	5	1	2	4.5	O=C(O)c1cccc(COc2ccc(C3CC3)cc2Cl)c1	nan
	7015981	183974	27	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cccc(Cl)c2Cl)c1	nan
	CHEMBL4848369	183974	27	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cccc(Cl)c2Cl)c1	nan
	155154180	184000	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	6	2	3	3.2	NC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4848664	184000	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	6	2	3	3.2	NC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	114322379	184009	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4848825	184009	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	155153838	184037	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1cccc(COc2ccc3sccc3c2)c1F	nan
	CHEMBL4849270	184037	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1cccc(COc2ccc3sccc3c2)c1F	nan
	155153758	184063	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	291	4	0	4	3.4	COC(=O)c1cccc(COc2ccc(Cl)cc2C)n1	nan
	CHEMBL4849588	184063	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	291	4	0	4	3.4	COC(=O)c1cccc(COc2ccc(Cl)cc2C)n1	nan
	155153970	184093	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	340	4	1	2	4.4	O=C(O)c1cccc(COc2cccc(Br)c2Cl)c1	nan
	CHEMBL4849913	184093	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	340	4	1	2	4.4	O=C(O)c1cccc(COc2cccc(Br)c2Cl)c1	nan
	155154172	184146	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	CHEMBL4850633	184146	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	155154044	184221	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	415	6	2	3	4.5	CC(C)(NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4851715	184221	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	415	6	2	3	4.5	CC(C)(NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	155145940	184431	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	311	3	0	2	4.8	N#Cc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4854872	184431	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	311	3	0	2	4.8	N#Cc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	84614649	184451	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	5	1	2	3.9	O=C(O)c1cccc(COc2ccc(C(F)F)cc2)c1	nan
	CHEMBL4855127	184451	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	5	1	2	3.9	O=C(O)c1cccc(COc2ccc(C(F)F)cc2)c1	nan
	155153740	184470	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	325	5	1	3	4.2	Cc1cc(-n2cccc2)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4855384	184470	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	325	5	1	3	4.2	Cc1cc(-n2cccc2)ccc1OCc1cccc(C(=O)O)c1F	nan
	107881084	184483	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1F	nan
	CHEMBL4855567	184483	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1F	nan
	155154045	184519	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	493	8	3	4	5.1	O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856071	184519	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	493	8	3	4	5.1	O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146040	184541	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	1	1	2	4.3	N#Cc1cc(C#Cc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4856356	184541	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	1	1	2	4.3	N#Cc1cc(C#Cc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145911	184574	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	4	1	2	4.0	NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4857097	184574	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	4	1	2	4.0	NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	102723930	184575	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)cc1Cl	nan
	CHEMBL4857110	184575	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)cc1Cl	nan
	155154009	184576	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	423	6	2	4	3.5	O=C(NCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	CHEMBL4857124	184576	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	423	6	2	4	3.5	O=C(NCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	155153960	184623	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)c(Cl)c2)cc(C(F)(F)F)c1	nan
	CHEMBL4857656	184623	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)c(Cl)c2)cc(C(F)(F)F)c1	nan
	155153995	184695	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccn1	nan
	CHEMBL4858920	184695	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccn1	nan
	155153774	184703	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	305	4	1	3	3.6	N#Cc1cc(Cl)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4859063	184703	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	305	4	1	3	3.6	N#Cc1cc(Cl)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	155154005	184709	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3ccsc3c2)c1	nan
	CHEMBL4859171	184709	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3ccsc3c2)c1	nan
	155146005	184711	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	429	7	2	3	4.8	CC(C)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4859266	184711	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	429	7	2	3	4.8	CC(C)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	106903220	184736	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	1	3	3.3	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)n1	nan
	CHEMBL4859510	184736	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	1	3	3.3	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)n1	nan
	155153791	184756	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	293	5	1	3	3.8	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2)c1	nan
	CHEMBL4859833	184756	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	293	5	1	3	3.8	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2)c1	nan
	155154252	184757	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4859840	184757	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	155154021	184769	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	405	5	1	2	6.2	O=C(Nc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4860115	184769	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	405	5	1	2	6.2	O=C(Nc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154007	184886	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	419	6	1	2	5.9	O=C(NCc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4861940	184886	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	419	6	1	2	5.9	O=C(NCc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	22682941	184919	2	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2)c1	nan
	CHEMBL4862434	184919	2	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2)c1	nan
	155153807	184974	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3occc3c2)c1	nan
	CHEMBL4863225	184974	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3occc3c2)c1	nan
	155153800	185016	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	3.9	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(C(F)(F)F)c1	nan
	CHEMBL4863762	185016	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	3.9	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(C(F)(F)F)c1	nan
	43531176	185036	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	281	4	1	2	4.0	NCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4864076	185036	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	281	4	1	2	4.0	NCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	137553505	185045	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	5	1	3	3.9	O=C(O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	CHEMBL4864265	185045	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	5	1	3	3.9	O=C(O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	155154133	185092	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	5	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)F)cc2F)c1	nan
	CHEMBL4865044	185092	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	5	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)F)cc2F)c1	nan
	7022231	185156	28	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1cccc(OCc2cccc(C(=O)O)c2)c1	nan
	CHEMBL4866106	185156	28	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1cccc(OCc2cccc(C(=O)O)c2)c1	nan
	113925944	185163	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)cc1F	nan
	CHEMBL4866201	185163	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)cc1F	nan
	155153793	185166	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2Cl)c1	nan
	CHEMBL4866223	185166	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2Cl)c1	nan
	29080666	185182	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2)c1	nan
	CHEMBL4866428	185182	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2)c1	nan
	155154248	185198	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4866577	185198	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	155153775	185212	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1cc(Cl)ccc1OCc1cccc(-c2nnn[nH]2)c1	nan
	CHEMBL4866840	185212	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1cc(Cl)ccc1OCc1cccc(-c2nnn[nH]2)c1	nan
	155145950	185261	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	376	5	0	3	5.3	CCOC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4867568	185261	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	376	5	0	3	5.3	CCOC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155153837	185263	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(F)(F)F)c1	nan
	CHEMBL4867604	185263	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(F)(F)F)c1	nan
	155146125	185269	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	444	8	3	4	3.0	NC(=O)C[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4867684	185269	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	444	8	3	4	3.0	NC(=O)C[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	43092667	185272	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4867744	185272	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	155154000	185288	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(C#N)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4868055	185288	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(C#N)ccc1OCc1cccc(C(=O)O)c1	nan
	155154006	185300	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	7	1	2	5.5	CCCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4868255	185300	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	7	1	2	5.5	CCCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153812	185342	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3sccc3c2)c1	nan
	CHEMBL4869118	185342	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3sccc3c2)c1	nan
	155153736	185357	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	5	1	3	4.5	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2Cl)c1F	nan
	CHEMBL4869336	185357	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	5	1	3	4.5	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2Cl)c1F	nan
	155154048	185358	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	516	8	3	3	5.8	O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4869352	185358	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	516	8	3	3	5.8	O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153773	185387	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	4	2.8	Cc1c(OCc2cccc(C(=O)O)c2)ccc2c1OCC2=O	nan
	CHEMBL4869694	185387	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	4	2.8	Cc1c(OCc2cccc(C(=O)O)c2)ccc2c1OCC2=O	nan
	155154141	185456	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	411	5	1	4	5.6	Cc1nc(-c2cc(COc3ccc(C(F)(F)F)cc3Cl)cc(C(=O)O)c2)co1	nan
	CHEMBL4870727	185456	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	411	5	1	4	5.6	Cc1nc(-c2cc(COc3ccc(C(F)(F)F)cc3Cl)cc(C(=O)O)c2)co1	nan
	155154020	185472	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	2	3	4.1	O=C(NCCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4870998	185472	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	2	3	4.1	O=C(NCCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154205	185498	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	6	2	3	3.7	O=C(NCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871418	185498	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	6	2	3	3.7	O=C(NCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154075	185545	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871892	185545	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153810	185553	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	343	4	1	2	4.3	CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4872055	185553	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	343	4	1	2	4.3	CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153994	185570	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	6	1	3	3.6	O=C(O)c1cccc(COc2ccc(OC(F)F)cc2)c1	nan
	CHEMBL4872342	185570	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	6	1	3	3.6	O=C(O)c1cccc(COc2ccc(OC(F)F)cc2)c1	nan
	155154215	185597	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	458	9	3	4	3.4	NC(=O)CC[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4872646	185597	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	458	9	3	4	3.4	NC(=O)CC[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	155154082	185603	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	0	3	3.2	COC(=O)c1cccc(COc2cccc(F)c2)c1	nan
	CHEMBL4872725	185603	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	0	3	3.2	COC(=O)c1cccc(COc2cccc(F)c2)c1	nan
	890775	185628	33	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4873123	185628	33	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccccc1OCc1cccc(C(=O)O)c1	nan
	584777	185648	43	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	262	4	1	2	3.6	O=C(O)c1cccc(COc2ccc(Cl)cc2)c1	nan
	CHEMBL4873423	185648	43	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	262	4	1	2	3.6	O=C(O)c1cccc(COc2ccc(Cl)cc2)c1	nan
	155154016	185673	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	371	5	1	2	5.1	CC(C)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4873773	185673	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	371	5	1	2	5.1	CC(C)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153999	185687	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4873923	185687	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	155146134	185688	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3ncc[nH]3)c2)c(Cl)c1	nan
	CHEMBL4873967	185688	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3ncc[nH]3)c2)c(Cl)c1	nan
	155146091	185735	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	2	4.7	CNCc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4874662	185735	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	2	4.7	CNCc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153987	185775	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	5	1	3	4.7	O=C(O)c1cc(F)cc(COc2ccc(OC(F)(F)F)cc2Cl)c1	nan
	CHEMBL4875200	185775	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	5	1	3	4.7	O=C(O)c1cc(F)cc(COc2ccc(OC(F)(F)F)cc2Cl)c1	nan
	156048221	185779	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	437	7	2	4	3.6	O=C(NCCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	CHEMBL4875343	185779	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	437	7	2	4	3.6	O=C(NCCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	155154219	185782	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	417	7	3	4	3.1	O=C(N[C@@H](CO)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4875377	185782	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	417	7	3	4	3.1	O=C(N[C@@H](CO)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	832097	185872	28	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2ccc3ccccc3c2)c1	nan
	CHEMBL4876586	185872	28	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2ccc3ccccc3c2)c1	nan
	155153971	185886	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1C#N	nan
	CHEMBL4876749	185886	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1C#N	nan
	155145974	185900	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	2	4.7	N#Cc1cc(CCc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4876954	185900	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	2	4.7	N#Cc1cc(CCc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	7015989	185901	29	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4877006	185901	29	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)c1	nan
	155154019	185913	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	357	5	1	2	4.7	CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4877244	185913	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	357	5	1	2	4.7	CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154178	185914	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	397	5	1	2	5.6	O=C(NC1CCCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4877261	185914	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	397	5	1	2	5.6	O=C(NC1CCCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155145948	185992	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	5	1	3	4.7	CN(C)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878337	185992	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	5	1	3	4.7	CN(C)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155153809	186000	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	383	5	1	2	5.2	O=C(NC1CCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4878428	186000	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	383	5	1	2	5.2	O=C(NC1CCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153794	186030	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	4	1	2	5.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1Cl	nan
	CHEMBL4879041	186030	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	4	1	2	5.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1Cl	nan
	929494	38767	30	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2ccc3c(c2)CCC3)c1	nan
	CHEMBL1468323	38767	30	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2ccc3c(c2)CCC3)c1	nan
	725872	42350	36	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	286	4	1	3	3.9	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)o1	nan
	CHEMBL1500515	42350	36	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	286	4	1	3	3.9	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)o1	nan
	891145	51772	31	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL1587117	51772	31	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	155146121	183853	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	358	5	1	2	5.2	CCc1c(COc2ccc(C(F)(F)F)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4846341	183853	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	358	5	1	2	5.2	CCc1c(COc2ccc(C(F)(F)F)cc2Cl)cccc1C(=O)O	nan
	17605178	183955	19	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	246	4	1	2	3.1	O=C(O)c1cccc(COc2ccccc2F)c1	nan
	CHEMBL4847901	183955	19	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	246	4	1	2	3.1	O=C(O)c1cccc(COc2ccccc2F)c1	nan
	7015983	183988	28	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	256	4	1	2	3.6	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1	nan
	CHEMBL4848511	183988	28	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	256	4	1	2	3.6	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1	nan
	155154010	183994	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	425	4	0	3	4.8	O=C(c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1)N1CCC2(COC2)C1	nan
	CHEMBL4848586	183994	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	425	4	0	3	4.8	O=C(c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1)N1CCC2(COC2)C1	nan
	155146163	184210	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	CHEMBL4851598	184210	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	28542041	184213	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccccc2C(F)(F)F)c1	nan
	CHEMBL4851647	184213	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccccc2C(F)(F)F)c1	nan
	155154015	184237	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	0	3	5.2	COC1CCN(C(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)CC1	nan
	CHEMBL4851939	184237	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	0	3	5.2	COC1CCN(C(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)CC1	nan
	155154056	184239	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	5	1	2	4.4	O=C(O)c1cccc(COCc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4851949	184239	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	5	1	2	4.4	O=C(O)c1cccc(COCc2ccc(Cl)cc2Cl)c1	nan
	155154148	184246	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1	nan
	CHEMBL4852032	184246	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1	nan
	22682321	184310	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4852959	184310	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	11472211	184461	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	2	4.6	O=C(O)c1cccc(COc2cccc(-c3ccccc3)c2)c1	nan
	CHEMBL4855304	184461	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	2	4.6	O=C(O)c1cccc(COc2cccc(-c3ccccc3)c2)c1	nan
	15487504	184485	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccccc1COc1ccc(Cl)cc1Cl	nan
	CHEMBL4855628	184485	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccccc1COc1ccc(Cl)cc1Cl	nan
	116688442	184533	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2cccc(Cl)c2F)c1	nan
	CHEMBL4856288	184533	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2cccc(Cl)c2F)c1	nan
	155154083	184585	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	0	4	4.0	COC(=O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	CHEMBL4857218	184585	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	0	4	4.0	COC(=O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	155153972	184652	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	5	1	3	4.1	COc1ccc(OCc2cccc(C(=O)O)c2)c2ccccc12	nan
	CHEMBL4858105	184652	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	5	1	3	4.1	COc1ccc(OCc2cccc(C(=O)O)c2)c2ccccc12	nan
	155146161	184688	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4858773	184688	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	65339188	184702	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	CHEMBL4859048	184702	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	13013688	184724	4	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	3	1	2	4.5	O=C(O)c1cccc(Oc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4859370	184724	4	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	3	1	2	4.5	O=C(O)c1cccc(Oc2ccc(Cl)cc2Cl)c1	nan
	155146132	184763	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cn2)c1	nan
	CHEMBL4860022	184763	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cn2)c1	nan
	155153997	184872	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1cc(Cl)cc(Cl)c1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4861721	184872	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1cc(Cl)cc(Cl)c1OCc1cccc(C(=O)O)c1	nan
	63531317	184889	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1ccc(F)c(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4861974	184889	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1ccc(F)c(COc2ccc(Cl)cc2Cl)c1	nan
	24225858	184894	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	5	3.3	COC(=O)c1cc(COc2ccc(Cl)cc2Cl)on1	nan
	CHEMBL4862041	184894	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	5	3.3	COC(=O)c1cc(COc2ccc(Cl)cc2Cl)on1	nan
	155153755	184910	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	0	5	3.1	COC(=O)c1cncc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4862314	184910	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	0	5	3.1	COC(=O)c1cncc(COc2ccc(Cl)cc2Cl)n1	nan
	155153805	184970	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	CHEMBL4863173	184970	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	155154003	184980	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	318	5	1	2	4.9	Cc1cc(-c2ccccc2)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4863275	184980	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	318	5	1	2	4.9	Cc1cc(-c2ccccc2)ccc1OCc1cccc(C(=O)O)c1	nan
	155154024	185018	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	5	1	2	3.8	O=C(O)c1cccc(COc2ccc(C3CC3)cc2)c1	nan
	CHEMBL4863823	185018	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	5	1	2	3.8	O=C(O)c1cccc(COc2ccc(C3CC3)cc2)c1	nan
	17605176	185020	3	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4863854	185020	3	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccccc1OCc1cccc(C(=O)O)c1	nan
	584738	185042	32	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)ccc2Cl)c1	nan
	CHEMBL4864171	185042	32	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)ccc2Cl)c1	nan
	155154171	185059	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2cccc3c2CCC3)c1	nan
	CHEMBL4864441	185059	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2cccc3c2CCC3)c1	nan
	20991272	185213	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1ccc(C(C)(C)C)c(OCc2cccc(C(=O)O)c2)c1	nan
	CHEMBL4866841	185213	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1ccc(C(C)(C)C)c(OCc2cccc(C(=O)O)c2)c1	nan
	20985043	185217	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)cc(Cl)c2)c1	nan
	CHEMBL4866888	185217	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)cc(Cl)c2)c1	nan
	721137	185225	46	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1cc(C(=O)O)ccc1OCc1ccc(Cl)cc1	nan
	CHEMBL4866984	185225	46	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1cc(C(=O)O)ccc1OCc1ccc(Cl)cc1	nan
	155153808	185284	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	3	3.5	O=C(O)c1cccc(COc2cccc3c2CCCC3=O)c1	nan
	CHEMBL4868006	185284	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	3	3.5	O=C(O)c1cccc(COc2cccc3c2CCCC3=O)c1	nan
	82096332	185331	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	295	4	2	2	4.3	O=C(O)c1cccc(CNc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4868865	185331	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	295	4	2	2	4.3	O=C(O)c1cccc(CNc2ccc(Cl)cc2Cl)c1	nan
	155153803	185386	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	372	6	2	3	3.6	NCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4869674	185386	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	372	6	2	3	3.6	NCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153783	185434	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	285	5	2	3	2.3	CNC(=O)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL4870496	185434	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	285	5	2	3	2.3	CNC(=O)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	155154195	185438	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1ccc(C(=O)O)cc1COc1ccc(Cl)cc1Cl	nan
	CHEMBL4870512	185438	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1ccc(C(=O)O)cc1COc1ccc(Cl)cc1Cl	nan
	8977162	185506	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	4	3.6	COC(=O)c1cccc(COc2ccc(C#N)cc2Cl)c1	nan
	CHEMBL4871542	185506	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	4	3.6	COC(=O)c1cccc(COc2ccc(C#N)cc2Cl)c1	nan
	155153984	185520	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	3	3.8	CC(=O)c1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4871699	185520	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	3	3.8	CC(=O)c1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	3288323	185530	31	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	270	5	1	2	4.1	CC(C)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL4871766	185530	31	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	270	5	1	2	4.1	CC(C)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	155153862	185585	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	4	1	2	4.1	OCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4872542	185585	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	4	1	2	4.1	OCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155146072	185608	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3cn[nH]n3)c2)c(Cl)c1	nan
	CHEMBL4872766	185608	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3cn[nH]n3)c2)c(Cl)c1	nan
	155153991	185680	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	CHEMBL4873848	185680	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	14974397	185698	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4874104	185698	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2)c1	nan
	155154050	185709	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	316	4	0	4	4.4	COC(=O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	CHEMBL4874272	185709	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	316	4	0	4	4.4	COC(=O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	81781305	185820	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1cc(F)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4875899	185820	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1cc(F)ccc1OCc1cccc(C(=O)O)c1	nan
	155146174	185852	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	4	0	1	5.9	FC(F)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4876298	185852	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	4	0	1	5.9	FC(F)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154076	185907	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)nc2)c1	nan
	CHEMBL4877160	185907	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)nc2)c1	nan
	155153754	186001	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	327	5	0	5	2.9	COC(=O)c1cccc(COc2ccc(N3CCOCC3)cc2)c1	nan
	CHEMBL4878462	186001	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	327	5	0	5	2.9	COC(=O)c1cccc(COc2ccc(N3CCOCC3)cc2)c1	nan
	155154070	186038	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1cc(C(C)(C)C)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4879226	186038	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1cc(C(C)(C)C)ccc1OCc1cccc(C(=O)O)c1	nan
	155154170	184165	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184165	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155145968	184442	2	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	184442	2	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155154002	184285	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	184285	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155145900	185526	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	185526	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153792	185243	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185243	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	4366362	184102	33	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184102	33	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	4366362	184102	33	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184102	33	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155145968	184442	2	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	184442	2	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146009	185771	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	185771	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146147	185798	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	185798	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145968	184442	2	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	184442	2	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146136	185956	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	185956	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155145946	184689	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	184689	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155146147	185798	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	185798	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145946	184689	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	184689	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155153902	184725	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	184725	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155145946	184689	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	184689	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155153934	185471	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	335	4	1	3	4.2	Cc1cc(C(F)(F)F)ccc1OCc1cc(C#N)cc(C(=O)O)c1	nan
	CHEMBL4870947	185471	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	335	4	1	3	4.2	Cc1cc(C(F)(F)F)ccc1OCc1cc(C#N)cc(C(=O)O)c1	nan
	155154002	184285	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	184285	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155145900	185526	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	185526	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	106903214	185662	2	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	185662	2	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	155153792	185243	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185243	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155153902	184725	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	184725	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146009	185771	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	185771	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146147	185798	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	185798	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155153792	185243	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185243	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155145946	184689	5	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	184689	5	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155145900	185526	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	185526	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146136	185956	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	185956	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155145968	184442	2	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	184442	2	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146147	185798	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	185798	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155154002	184285	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	184285	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155146067	184024	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	184024	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155145900	185526	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	185526	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155145968	184442	2	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	184442	2	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	106903214	185662	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	185662	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	4366362	184102	33	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184102	33	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155154251	184556	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	184556	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155153792	185243	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185243	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155153792	185243	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185243	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155146136	185956	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	185956	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155154251	184556	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	184556	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155153902	184725	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	184725	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	107119671	184268	1	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	CHEMBL4852376	184268	1	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	155146067	184024	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	184024	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155146136	185956	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	185956	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155145946	184689	5	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	184689	5	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155145900	185526	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	185526	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146009	185771	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	185771	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146047	186015	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	186015	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155146009	185771	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	185771	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146136	185956	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	185956	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155146136	185956	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	185956	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155154251	184556	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	184556	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155146147	185798	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	185798	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	4366362	184102	33	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184102	33	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155154251	184556	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	184556	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155146009	185771	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	185771	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155153902	184725	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	184725	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153902	184725	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	184725	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	106903214	185662	2	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	185662	2	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	4366362	184102	33	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184102	33	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155153780	185723	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	185723	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155154170	184165	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184165	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155154170	184165	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184165	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	890753	31403	36	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2cccc3ccccc23)c1	nan
	CHEMBL1404550	31403	36	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2cccc3ccccc23)c1	nan
	155146086	183914	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	5	1	2	4.9	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2C2CC2)c1	nan
	CHEMBL4847344	183914	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	5	1	2	4.9	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2C2CC2)c1	nan
	155146130	183929	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	3	1	2	4.2	O=C1NCCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc21	nan
	CHEMBL4847516	183929	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	3	1	2	4.2	O=C1NCCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc21	nan
	155154149	183932	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	3.6	Cc1cc(F)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4847582	183932	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	3.6	Cc1cc(F)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	155153911	184079	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3ccoc3c2)c1	nan
	CHEMBL4849736	184079	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3ccoc3c2)c1	nan
	155146026	184149	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3cnc[nH]3)c2)c(Cl)c1	nan
	CHEMBL4850676	184149	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3cnc[nH]3)c2)c(Cl)c1	nan
	155154004	184151	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	5	1	3	3.3	COc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1F	nan
	CHEMBL4850688	184151	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	5	1	3	3.3	COc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1F	nan
	19619635	184208	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	CHEMBL4851582	184208	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	91105735	184211	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.1	O=C(O)c1cccc(COc2ccc(F)cc2C(F)(F)F)c1	nan
	CHEMBL4851614	184211	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.1	O=C(O)c1cccc(COc2ccc(F)cc2C(F)(F)F)c1	nan
	903815	184216	34	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL4851668	184216	34	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)cc1	nan
	155153785	184217	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3nc[nH]n3)c2)c(Cl)c1	nan
	CHEMBL4851669	184217	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3nc[nH]n3)c2)c(Cl)c1	nan
	155154017	184315	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	1	3	4.3	COCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4852989	184315	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	1	3	4.3	COCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	4442182	184317	37	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2cccc(Br)c2)c1	nan
	CHEMBL4853044	184317	37	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2cccc(Br)c2)c1	nan
	103238459	184351	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	2	2	4.2	O=C(O)c1cccc(CNc2ccc3ccccc3c2)c1	nan
	CHEMBL4853544	184351	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	2	2	4.2	O=C(O)c1cccc(CNc2ccc3ccccc3c2)c1	nan
	155154052	184371	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	338	4	1	2	4.1	C#Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4853811	184371	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	338	4	1	2	4.1	C#Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155146123	184478	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	366	4	1	3	4.2	O=S(=O)(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4855464	184478	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	366	4	1	3	4.2	O=S(=O)(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155784453	184523	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(N[C@H]1CC[C@H](O)CC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856138	184523	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(N[C@H]1CC[C@H](O)CC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146049	184525	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	3	1	2	4.5	Nc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856167	184525	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	3	1	2	4.5	Nc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154204	184535	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(NC1CCCC(O)C1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856296	184535	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(NC1CCCC(O)C1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154013	184569	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	406	5	1	2	6.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(-c2ccccc2)c1	nan
	CHEMBL4857004	184569	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	406	5	1	2	6.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(-c2ccccc2)c1	nan
	155153735	184679	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	5	1	3	4.4	O=C(O)c1cccc(COc2ccc(N3CCCC3)cc2Cl)c1F	nan
	CHEMBL4858571	184679	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	5	1	3	4.4	O=C(O)c1cccc(COc2ccc(N3CCCC3)cc2Cl)c1F	nan
	155153998	184743	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	279	4	1	3	3.5	O=C(O)c1cccc(COc2ccc3ccncc3c2)c1	nan
	CHEMBL4859587	184743	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	279	4	1	3	3.5	O=C(O)c1cccc(COc2ccc3ccncc3c2)c1	nan
	155153813	184839	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	6	2	3	3.4	CNC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4861329	184839	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	6	2	3	3.4	CNC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154400	184844	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	7	1	3	4.2	CN(C)CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4861423	184844	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	7	1	3	4.2	CN(C)CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154049	184848	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	431	7	3	4	3.5	C[C@@H](O)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4861439	184848	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	431	7	3	4	3.5	C[C@@H](O)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	155154027	184851	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1Cl	nan
	CHEMBL4861452	184851	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1Cl	nan
	155146107	184890	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	362	4	0	3	4.9	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4861980	184890	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	362	4	0	3	4.9	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155154040	185009	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1ccc(OCc2ccc(-c3nnn[nH]3)cc2)c(Cl)c1	nan
	CHEMBL4863644	185009	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1ccc(OCc2ccc(-c3nnn[nH]3)cc2)c(Cl)c1	nan
	155153798	185062	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	7	2	3	3.9	CNCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4864507	185062	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	7	2	3	3.9	CNCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154046	185067	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	401	6	2	3	4.1	C[C@@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4864569	185067	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	401	6	2	3	4.1	C[C@@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	106903207	185069	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	263	4	1	3	3.0	O=C(O)c1cccc(COc2ccc(Cl)cc2)n1	nan
	CHEMBL4864640	185069	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	263	4	1	3	3.0	O=C(O)c1cccc(COc2ccc(Cl)cc2)n1	nan
	155153702	185164	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	4	1	4	3.3	O=C(O)c1cccc(COc2ccc3c(c2)OC(F)(F)O3)c1	nan
	CHEMBL4866218	185164	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	4	1	4	3.3	O=C(O)c1cccc(COc2ccc3c(c2)OC(F)(F)O3)c1	nan
	62669913	185196	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4866560	185196	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	155153739	185256	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	3	4.0	Cc1cc(N2CCCC2)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4867549	185256	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	3	4.0	Cc1cc(N2CCCC2)ccc1OCc1cccc(C(=O)O)c1F	nan
	155153757	185293	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	4	0	4	4.1	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4868173	185293	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	4	0	4	4.1	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	19620501	185311	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	CHEMBL4868548	185311	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	155701700	185330	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	274	4	1	2	3.7	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1F	nan
	CHEMBL4868856	185330	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	274	4	1	2	3.7	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1F	nan
	155153801	185338	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	322	5	1	2	4.8	O=C(O)c1cccc(COc2cccc(-c3ccc(F)cc3)c2)c1	nan
	CHEMBL4869062	185338	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	322	5	1	2	4.8	O=C(O)c1cccc(COc2cccc(-c3ccc(F)cc3)c2)c1	nan
	155153802	185537	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	0	3	4.4	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCOC1	nan
	CHEMBL4871829	185537	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	0	3	4.4	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCOC1	nan
	155154216	185547	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	467	8	3	4	4.1	O=C(N[C@@H](Cc1c[nH]cn1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871932	185547	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	467	8	3	4	4.1	O=C(N[C@@H](Cc1c[nH]cn1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154203	185584	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	413	4	1	3	4.5	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCCC(O)C1	nan
	CHEMBL4872532	185584	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	413	4	1	3	4.5	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCCC(O)C1	nan
	155154200	185610	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	1	3	3.8	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CC(O)C1	nan
	CHEMBL4872809	185610	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	1	3	3.8	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CC(O)C1	nan
	155146160	185706	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	369	3	0	2	4.6	CN1CCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc2C1=O	nan
	CHEMBL4874203	185706	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	369	3	0	2	4.6	CN1CCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc2C1=O	nan
	155146102	185736	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	4	1	2	4.5	O=C1CC(c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)N1	nan
	CHEMBL4874670	185736	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	4	1	2	4.5	O=C1CC(c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)N1	nan
	29789593	185742	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	3	0	2	4.4	N#Cc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4874777	185742	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	3	0	2	4.4	N#Cc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	20984378	185876	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	290	4	1	2	4.2	Cc1cc(OCc2cccc(C(=O)O)c2)cc(C)c1Cl	nan
	CHEMBL4876625	185876	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	290	4	1	2	4.2	Cc1cc(OCc2cccc(C(=O)O)c2)cc(C)c1Cl	nan
	155154217	185902	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	449	6	2	3	5.9	O=C(O)c1ccc(NC(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)cc1	nan
	CHEMBL4877028	185902	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	449	6	2	3	5.9	O=C(O)c1ccc(NC(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)cc1	nan
	155154152	185919	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2ccc(Cl)cc2F)c1	nan
	CHEMBL4877399	185919	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2ccc(Cl)cc2F)c1	nan
	155153804	185968	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.0	COc1cc(OCc2cccc(C(=O)O)c2)ccc1C(F)(F)F	nan
	CHEMBL4878001	185968	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.0	COc1cc(OCc2cccc(C(=O)O)c2)ccc1C(F)(F)F	nan
	107119671	184268	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	CHEMBL4852376	184268	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	4366362	184102	33	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184102	33	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155145968	184442	2	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	184442	2	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146047	186015	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	186015	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155153780	185723	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	185723	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155146067	184024	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	184024	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155146067	184024	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	184024	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155153780	185723	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	185723	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155154251	184556	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	184556	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155153792	185243	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185243	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155153780	185723	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	185723	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155146047	186015	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	186015	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145946	184689	5	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	184689	5	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155154170	184165	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184165	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155154002	184285	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	184285	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155153780	185723	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	185723	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155146047	186015	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	186015	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	106903214	185662	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	185662	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	107119671	184268	1	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	CHEMBL4852376	184268	1	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	155145900	185526	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	185526	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154170	184165	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184165	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155154002	184285	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	184285	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)