Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| CHEMBL427807 | 220164 | 0 | None | 1 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O | 10.1021/jm990590f | ||||
| 57397279 | 76774 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 390 | 6 | 0 | 6 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC(F)F)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939594 | 76774 | 0 | None | - | 1 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 390 | 6 | 0 | 6 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC(F)F)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 127032015 | 145416 | 0 | None | - | 1 | Mouse | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 3561 | 116 | 51 | 45 | -9.7 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](N)Cc2ccccc2)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | ||
| CHEMBL3775924 | 145416 | 0 | None | - | 1 | Mouse | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 3561 | 116 | 51 | 45 | -9.7 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](N)Cc2ccccc2)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | ||
| 127032315 | 145206 | 0 | None | 1 | 2 | Mouse | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 3880 | 126 | 55 | 49 | -10.4 | CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | ||
| CHEMBL3774395 | 145206 | 0 | None | 1 | 2 | Mouse | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 3880 | 126 | 55 | 49 | -10.4 | CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | ||
| CHEMBL4299295 | 220341 | 0 | None | 1 | 2 | Mouse | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(=O)O)NC(C)=O)[C@H](C)O)C(C)C)C(=O)N[C@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | ||||
| 57390212 | 76782 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 367 | 5 | 0 | 5 | 4.5 | CCC(CC)c1cc(C)n2nc(-c3c(C)cc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939601 | 76782 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 367 | 5 | 0 | 5 | 4.5 | CCC(CC)c1cc(C)n2nc(-c3c(C)cc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 127030817 | 145285 | 0 | None | 1 | 2 | Mouse | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 3824 | 122 | 55 | 49 | -12.0 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | ||
| CHEMBL3774939 | 145285 | 0 | None | 1 | 2 | Mouse | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 3824 | 122 | 55 | 49 | -12.0 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | ||
| 57395433 | 76763 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 387 | 6 | 0 | 5 | 5.1 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(CC)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939583 | 76763 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 387 | 6 | 0 | 5 | 5.1 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(CC)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 11153312 | 72280 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 383 | 6 | 1 | 6 | 5.5 | CCC(CC)n1ccc2c(Nc3ccc(OC)cc3Cl)nc3ccnn3c21 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1830523 | 72280 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 383 | 6 | 1 | 6 | 5.5 | CCC(CC)n1ccc2c(Nc3ccc(OC)cc3Cl)nc3ccnn3c21 | 10.1016/j.bmc.2011.08.055 | ||
| 127033542 | 145400 | 0 | None | 1 | 2 | Mouse | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 3960 | 128 | 56 | 50 | -10.4 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | ||
| CHEMBL3775796 | 145400 | 0 | None | 1 | 2 | Mouse | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 3960 | 128 | 56 | 50 | -10.4 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | ||
| 25115057 | 76768 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 399 | 6 | 0 | 5 | 5.4 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C3CC3)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939588 | 76768 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 399 | 6 | 0 | 5 | 5.4 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C3CC3)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 57393713 | 76773 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 354 | 5 | 0 | 6 | 3.6 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939593 | 76773 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 354 | 5 | 0 | 6 | 3.6 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 57400682 | 76777 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 359 | 4 | 0 | 5 | 4.2 | CCC(C)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939597 | 76777 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 359 | 4 | 0 | 5 | 4.2 | CCC(C)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 145958142 | 168837 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 383 | 6 | 1 | 6 | 4.8 | CCCCN(CC)c1nc(C)nc2c1sc(=N)n2-c1c(C)cc(C)cc1C | 10.1016/j.ejmech.2017.07.016 | ||
| CHEMBL4160471 | 168837 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 383 | 6 | 1 | 6 | 4.8 | CCCCN(CC)c1nc(C)nc2c1sc(=N)n2-c1c(C)cc(C)cc1C | 10.1016/j.ejmech.2017.07.016 | ||
| 57397276 | 76751 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 373 | 5 | 0 | 5 | 4.6 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939571 | 76751 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 373 | 5 | 0 | 5 | 4.6 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 57392001 | 76762 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 367 | 6 | 0 | 5 | 4.7 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939582 | 76762 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 367 | 6 | 0 | 5 | 4.7 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 57393711 | 76750 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 353 | 5 | 0 | 5 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939570 | 76750 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 353 | 5 | 0 | 5 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 24758072 | 76752 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 320 | 4 | 0 | 2 | 6.1 | CCC(CC)c1cc(C)n2nc(-c3ccc(C)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939572 | 76752 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 320 | 4 | 0 | 2 | 6.1 | CCC(CC)c1cc(C)n2nc(-c3ccc(C)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | ||
| 24758076 | 76756 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 380 | 7 | 0 | 4 | 6.1 | CCc1cc(OC)c(OC)cc1-c1nn2c(C)cc(C(CC)CC)c2cc1C | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939576 | 76756 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 380 | 7 | 0 | 4 | 6.1 | CCc1cc(OC)c(OC)cc1-c1nn2c(C)cc(C(CC)CC)c2cc1C | 10.1016/j.bmc.2011.11.015 | ||
| 56665181 | 71534 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 386 | 6 | 1 | 5 | 5.6 | CCC(CC)Nc1c(C)c(C)nc2c(-c3ccc(OC)cc3Cl)c(C)nn12 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819085 | 71534 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 386 | 6 | 1 | 5 | 5.6 | CCC(CC)Nc1c(C)c(C)nc2c(-c3ccc(OC)cc3Cl)c(C)nn12 | 10.1016/j.bmc.2011.07.055 | ||
| 24758075 | 76757 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 350 | 5 | 0 | 4 | 5.3 | CCC(CC)c1cc(C)n2nc(-c3cnc(N(C)C)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939577 | 76757 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 350 | 5 | 0 | 4 | 5.3 | CCC(CC)c1cc(C)n2nc(-c3cnc(N(C)C)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | ||
| 10024020 | 209881 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 401 | 9 | 0 | 5 | 5.2 | CCCN(c1nccc(-c2c(Cl)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | ||
| CHEMBL63989 | 209881 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 401 | 9 | 0 | 5 | 5.2 | CCCN(c1nccc(-c2c(Cl)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | ||
| 56677028 | 72073 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 359 | 7 | 2 | 6 | 4.7 | CCC(CC)Nc1cc(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1828886 | 72073 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 359 | 7 | 2 | 6 | 4.7 | CCC(CC)Nc1cc(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| 44290322 | 107947 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 382 | 8 | 0 | 6 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1021/jm990590f | ||
| CHEMBL295563 | 107947 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 382 | 8 | 0 | 6 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1021/jm990590f | ||
| 10178898 | 71515 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 396 | 6 | 1 | 6 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CSC2 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819065 | 71515 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 396 | 6 | 1 | 6 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CSC2 | 10.1016/j.bmc.2011.07.055 | ||
| 10024020 | 209881 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 401 | 9 | 0 | 5 | 5.2 | CCCN(c1nccc(-c2c(Cl)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | ||
| CHEMBL63989 | 209881 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 401 | 9 | 0 | 5 | 5.2 | CCCN(c1nccc(-c2c(Cl)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | ||
| 57400680 | 76771 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 354 | 5 | 0 | 6 | 3.6 | CCC(CC)c1cc(C)n2nc(-c3cnc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939591 | 76771 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 354 | 5 | 0 | 6 | 3.6 | CCC(CC)c1cc(C)n2nc(-c3cnc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 10177704 | 71510 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 5.1 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819060 | 71510 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 378 | 6 | 1 | 5 | 5.1 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | ||
| 56680359 | 72085 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 401 | 9 | 0 | 6 | 5.2 | CCCN(CCC)c1cc(N(CC)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1828897 | 72085 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 401 | 9 | 0 | 6 | 5.2 | CCCN(CCC)c1cc(N(CC)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| 57400681 | 76775 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 339 | 4 | 0 | 5 | 3.8 | CCC(C)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939595 | 76775 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 339 | 4 | 0 | 5 | 3.8 | CCC(C)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 24758074 | 76755 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 350 | 4 | 0 | 4 | 5.6 | CCC(CC)c1cc(C)n2nc(-c3cc4c(cc3C)OCO4)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939575 | 76755 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 350 | 4 | 0 | 4 | 5.6 | CCC(CC)c1cc(C)n2nc(-c3cc4c(cc3C)OCO4)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | ||
| 25114821 | 76772 | 0 | None | -1 | 2 | Rat | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 390 | 6 | 0 | 6 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3cnc(OC(F)F)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939592 | 76772 | 0 | None | -1 | 2 | Rat | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 390 | 6 | 0 | 6 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3cnc(OC(F)F)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 10222795 | 71531 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 402 | 5 | 1 | 4 | 6.1 | CCC(CC)Nc1c2c(nc3c(-c4ccc(Cl)cc4Cl)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819082 | 71531 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 402 | 5 | 1 | 4 | 6.1 | CCC(CC)Nc1c2c(nc3c(-c4ccc(Cl)cc4Cl)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | ||
| 56668632 | 71532 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 434 | 7 | 1 | 5 | 6.0 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC(F)F)cc4Cl)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819083 | 71532 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 434 | 7 | 1 | 5 | 6.0 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC(F)F)cc4Cl)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | ||
| 56659877 | 72080 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 415 | 9 | 1 | 6 | 5.9 | CCCN(CCC)c1c(C(C)C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1828892 | 72080 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 415 | 9 | 1 | 6 | 5.9 | CCCN(CCC)c1c(C(C)C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| 56683765 | 72279 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 388 | 8 | 0 | 7 | 4.2 | CCCN(CCC)c1nc(N(C)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1830522 | 72279 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 388 | 8 | 0 | 7 | 4.2 | CCCN(CCC)c1nc(N(C)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| 56683688 | 72088 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 413 | 10 | 0 | 6 | 5.3 | C=CCN(c1cc(N(CCC)CCC)n2nccc2n1)c1ccc(OC)cc1Cl | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1828900 | 72088 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 413 | 10 | 0 | 6 | 5.3 | C=CCN(c1cc(N(CCC)CCC)n2nccc2n1)c1ccc(OC)cc1Cl | 10.1016/j.bmc.2011.08.055 | ||
| 25114821 | 76772 | 0 | None | 1 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 390 | 6 | 0 | 6 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3cnc(OC(F)F)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939592 | 76772 | 0 | None | 1 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 390 | 6 | 0 | 6 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3cnc(OC(F)F)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 24758071 | 76753 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 334 | 4 | 0 | 2 | 6.4 | CCC(CC)c1cc(C)n2nc(-c3cc(C)c(C)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939573 | 76753 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 334 | 4 | 0 | 2 | 6.4 | CCC(CC)c1cc(C)n2nc(-c3cc(C)c(C)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL429560 | 220319 | 0 | None | -2 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(N)=O | 10.1021/jm990590f | ||||
| CHEMBL2372650 | 217058 | 0 | None | 3 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(N)=O | 10.1021/jm990590f | ||||
| 57398970 | 76765 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 403 | 7 | 1 | 6 | 4.0 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(CCO)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939585 | 76765 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 403 | 7 | 1 | 6 | 4.0 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(CCO)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 57402456 | 76784 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 353 | 4 | 0 | 5 | 4.1 | CCC(C)c1cc(C)n2nc(-c3c(C)cc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939603 | 76784 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 353 | 4 | 0 | 5 | 4.1 | CCC(C)c1cc(C)n2nc(-c3c(C)cc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 11588927 | 72281 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 377 | 7 | 1 | 6 | 5.4 | CCc1cc(OC)ccc1Nc1nc2ccnn2c2c1ccn2C(CC)CC | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1830524 | 72281 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 377 | 7 | 1 | 6 | 5.4 | CCc1cc(OC)ccc1Nc1nc2ccnn2c2c1ccn2C(CC)CC | 10.1016/j.bmc.2011.08.055 | ||
| 57397278 | 76767 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 379 | 6 | 0 | 5 | 5.0 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C3CC3)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939587 | 76767 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 379 | 6 | 0 | 5 | 5.0 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C3CC3)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 56659949 | 72282 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 381 | 6 | 1 | 5 | 6.0 | CCc1cc(Cl)ccc1Nc1nc2ccnn2c2c1ccn2C(CC)CC | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1830525 | 72282 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 381 | 6 | 1 | 5 | 6.0 | CCc1cc(Cl)ccc1Nc1nc2ccnn2c2c1ccn2C(CC)CC | 10.1016/j.bmc.2011.08.055 | ||
| 56678852 | 71533 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 372 | 6 | 1 | 5 | 5.3 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3Cl)c(C)nn12 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819084 | 71533 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 372 | 6 | 1 | 5 | 5.3 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3Cl)c(C)nn12 | 10.1016/j.bmc.2011.07.055 | ||
| 56670271 | 72283 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 360 | 5 | 0 | 4 | 5.6 | CCC(CC)n1ccc2c(Cc3c(C)cc(C)cc3C)nc3ccnn3c21 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1830526 | 72283 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 360 | 5 | 0 | 4 | 5.6 | CCC(CC)n1ccc2c(Cc3c(C)cc(C)cc3C)nc3ccnn3c21 | 10.1016/j.bmc.2011.08.055 | ||
| 57400683 | 76781 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 353 | 4 | 0 | 6 | 3.3 | CCC(C)c1cc(C)n2nc(-c3ccc(N(C)C)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939600 | 76781 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 353 | 4 | 0 | 6 | 3.3 | CCC(C)c1cc(C)n2nc(-c3ccc(N(C)C)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 56659947 | 72272 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 374 | 7 | 1 | 7 | 4.2 | CCC(CC)Nc1cc(N(C)c2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1830516 | 72272 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 374 | 7 | 1 | 7 | 4.2 | CCC(CC)Nc1cc(N(C)c2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL428505 | 220231 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(N)=O | 10.1021/jm990590f | ||||
| 136042278 | 76761 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 359 | 5 | 1 | 4 | 4.6 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)[nH]c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939581 | 76761 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 359 | 5 | 1 | 4 | 4.6 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)[nH]c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 11383650 | 72076 | 0 | None | 14 | 2 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 387 | 8 | 1 | 6 | 5.1 | CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1828889 | 72076 | 0 | None | 14 | 2 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 387 | 8 | 1 | 6 | 5.1 | CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| 56668633 | 71535 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 400 | 6 | 1 | 6 | 4.9 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4Cl)c(C)nn13)CCO2 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819086 | 71535 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 400 | 6 | 1 | 6 | 4.9 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4Cl)c(C)nn13)CCO2 | 10.1016/j.bmc.2011.07.055 | ||
| 11552261 | 72284 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 361 | 5 | 1 | 5 | 5.7 | CCC(CC)n1ccc2c(Nc3c(C)cc(C)cc3C)nc3ccnn3c21 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1830527 | 72284 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 361 | 5 | 1 | 5 | 5.7 | CCC(CC)n1ccc2c(Nc3c(C)cc(C)cc3C)nc3ccnn3c21 | 10.1016/j.bmc.2011.08.055 | ||
| 57400679 | 76764 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 383 | 7 | 1 | 6 | 3.7 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CCO)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939584 | 76764 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 383 | 7 | 1 | 6 | 3.7 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CCO)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 54754517 | 72270 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 417 | 10 | 0 | 7 | 4.8 | CCCN(CCC)c1cc(N(COC)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1830514 | 72270 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 417 | 10 | 0 | 7 | 4.8 | CCCN(CCC)c1cc(N(COC)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| 57398972 | 76783 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 339 | 3 | 0 | 5 | 3.8 | COc1cc(C)c(-c2nn3c(C)cc(C(C)C)c3c(=O)n2C)c(C)c1 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939602 | 76783 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 339 | 3 | 0 | 5 | 3.8 | COc1cc(C)c(-c2nn3c(C)cc(C(C)C)c3c(=O)n2C)c(C)c1 | 10.1016/j.bmc.2011.11.015 | ||
| 16126888 | 76749 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 336 | 5 | 0 | 3 | 5.8 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939569 | 76749 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 336 | 5 | 0 | 3 | 5.8 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | ||
| 10376 | 9704 | 4 | None | 1 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 398 | 6 | 1 | 5 | 5.5 | CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC | 10.1016/j.bmc.2011.07.055 | ||
| 9801039 | 9704 | 4 | None | 1 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 398 | 6 | 1 | 5 | 5.5 | CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819077 | 9704 | 4 | None | 1 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 398 | 6 | 1 | 5 | 5.5 | CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC | 10.1016/j.bmc.2011.07.055 | ||
| 10376 | 9704 | 4 | None | -1 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 398 | 6 | 1 | 5 | 5.5 | CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC | 10.1016/j.bmc.2011.07.055 | ||
| 9801039 | 9704 | 4 | None | -1 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 398 | 6 | 1 | 5 | 5.5 | CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819077 | 9704 | 4 | None | -1 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 398 | 6 | 1 | 5 | 5.5 | CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC | 10.1016/j.bmc.2011.07.055 | ||
| 56683763 | 72275 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 387 | 8 | 1 | 6 | 5.1 | CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2nccn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1830519 | 72275 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 387 | 8 | 1 | 6 | 5.1 | CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2nccn12 | 10.1016/j.bmc.2011.08.055 | ||
| 10135150 | 71525 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 392 | 6 | 1 | 5 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4cc(C)c(OC)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819075 | 71525 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 392 | 6 | 1 | 5 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4cc(C)c(OC)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | ||
| 57390211 | 76769 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 395 | 7 | 0 | 5 | 5.3 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC(C)C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939589 | 76769 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 395 | 7 | 0 | 5 | 5.3 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC(C)C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 57398971 | 76770 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 393 | 7 | 0 | 5 | 5.1 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC3CC3)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939590 | 76770 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 393 | 7 | 0 | 5 | 5.1 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC3CC3)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 57397277 | 76766 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 381 | 6 | 0 | 5 | 5.3 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C(C)C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939586 | 76766 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 381 | 6 | 0 | 5 | 5.3 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C(C)C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 57393714 | 76778 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 367 | 5 | 0 | 6 | 3.7 | CCC(CC)c1cc(C)n2nc(-c3ccc(N(C)C)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939598 | 76778 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 367 | 5 | 0 | 6 | 3.7 | CCC(CC)c1cc(C)n2nc(-c3ccc(N(C)C)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 11703582 | 72285 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 378 | 7 | 0 | 6 | 5.4 | CCc1ccc(Oc2nc3ccnn3c3c2ccn3C(CC)CC)c(OC)c1 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1830528 | 72285 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 378 | 7 | 0 | 6 | 5.4 | CCc1ccc(Oc2nc3ccnn3c3c2ccn3C(CC)CC)c(OC)c1 | 10.1016/j.bmc.2011.08.055 | ||
| 56673724 | 72075 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 373 | 8 | 1 | 6 | 4.8 | CCCN(CCC)c1cc(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1828888 | 72075 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 373 | 8 | 1 | 6 | 4.8 | CCCN(CCC)c1cc(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| 57393712 | 76759 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 337 | 5 | 0 | 4 | 5.2 | CCC(CC)c1nc(C)n2nc(-c3ccc(OC)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939579 | 76759 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 337 | 5 | 0 | 4 | 5.2 | CCC(CC)c1nc(C)n2nc(-c3ccc(OC)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | ||
| 56670270 | 72271 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 374 | 7 | 2 | 7 | 4.4 | CCC(CC)Nc1c(C)c(Nc2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1830515 | 72271 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 374 | 7 | 2 | 7 | 4.4 | CCC(CC)Nc1c(C)c(Nc2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL2373995 | 217161 | 0 | None | -4 | 2 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)N[C@@H](CC(=O)O)C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CC(N)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm990590f | ||||
| 24758073 | 76754 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 0 | 3 | 6.5 | CCOc1ccc(-c2nn3c(C)cc(C(CC)CC)c3cc2C)c(CC)c1 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939574 | 76754 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 0 | 3 | 6.5 | CCOc1ccc(-c2nn3c(C)cc(C(CC)CC)c3cc2C)c(CC)c1 | 10.1016/j.bmc.2011.11.015 | ||
| 22177839 | 71511 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 380 | 6 | 1 | 6 | 4.6 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CCO2 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819061 | 71511 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 380 | 6 | 1 | 6 | 4.6 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CCO2 | 10.1016/j.bmc.2011.07.055 | ||
| 22177742 | 71536 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 400 | 6 | 1 | 6 | 5.0 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4Cl)c(C)nn13)COC2 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819087 | 71536 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 400 | 6 | 1 | 6 | 5.0 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4Cl)c(C)nn13)COC2 | 10.1016/j.bmc.2011.07.055 | ||
| 136042277 | 76760 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 339 | 5 | 1 | 4 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)[nH]c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939580 | 76760 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 339 | 5 | 1 | 4 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)[nH]c(=O)c12 | 10.1016/j.bmc.2011.11.015 | ||
| 57402455 | 76776 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 345 | 3 | 0 | 5 | 3.8 | COc1ccc(-c2nn3c(C)cc(C(C)C)c3c(=O)n2C)c(Cl)c1 | 10.1016/j.bmc.2011.11.015 | ||
| CHEMBL1939596 | 76776 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 345 | 3 | 0 | 5 | 3.8 | COc1ccc(-c2nn3c(C)cc(C(C)C)c3c(=O)n2C)c(Cl)c1 | 10.1016/j.bmc.2011.11.015 | ||
| 54754515 | 72074 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 373 | 7 | 2 | 6 | 5.0 | CCC(CC)Nc1c(C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1828887 | 72074 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 373 | 7 | 2 | 6 | 5.0 | CCC(CC)Nc1c(C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| 9970050 | 71514 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 380 | 6 | 1 | 6 | 4.7 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)COC2 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819064 | 71514 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 380 | 6 | 1 | 6 | 4.7 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)COC2 | 10.1016/j.bmc.2011.07.055 | ||
| 56670201 | 72086 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 415 | 10 | 0 | 6 | 5.6 | CCCN(CCC)c1cc(N(CCC)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1828898 | 72086 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 415 | 10 | 0 | 6 | 5.6 | CCCN(CCC)c1cc(N(CCC)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| 56663414 | 72278 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 401 | 9 | 0 | 6 | 5.2 | CCCN(CCC)c1cc(N(CC)c2ccc(OC)cc2Cl)nc2nccn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1830521 | 72278 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 401 | 9 | 0 | 6 | 5.2 | CCCN(CCC)c1cc(N(CC)c2ccc(OC)cc2Cl)nc2nccn12 | 10.1016/j.bmc.2011.08.055 | ||
| 56668634 | 71537 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 400 | 6 | 1 | 6 | 4.9 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4Cl)c(C)nn13)OCC2 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819088 | 71537 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 400 | 6 | 1 | 6 | 4.9 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4Cl)c(C)nn13)OCC2 | 10.1016/j.bmc.2011.07.055 | ||
| 54754516 | 72078 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 401 | 9 | 1 | 6 | 5.3 | CCCN(CCC)c1c(CC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1828890 | 72078 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 401 | 9 | 1 | 6 | 5.3 | CCCN(CCC)c1c(CC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| 10111139 | 71526 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 392 | 6 | 1 | 5 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4c(C)cc(OC)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819076 | 71526 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 392 | 6 | 1 | 5 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4c(C)cc(OC)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | ||
| 11383650 | 72076 | 0 | None | -14 | 2 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 387 | 8 | 1 | 6 | 5.1 | CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1828889 | 72076 | 0 | None | -14 | 2 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 387 | 8 | 1 | 6 | 5.1 | CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| 56663337 | 72087 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 427 | 10 | 0 | 6 | 5.7 | C=C(C)CN(c1cc(N(CCC)CCC)n2nccc2n1)c1ccc(OC)cc1Cl | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1828899 | 72087 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 427 | 10 | 0 | 6 | 5.7 | C=C(C)CN(c1cc(N(CCC)CCC)n2nccc2n1)c1ccc(OC)cc1Cl | 10.1016/j.bmc.2011.08.055 | ||
| 56673725 | 72083 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 403 | 9 | 1 | 7 | 4.8 | CCCN(CCC)c1c(OC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1828895 | 72083 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 403 | 9 | 1 | 7 | 4.8 | CCCN(CCC)c1c(OC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| 56683762 | 72274 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 388 | 8 | 0 | 7 | 4.2 | CCCN(CCC)c1cc(N(C)c2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1830518 | 72274 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 388 | 8 | 0 | 7 | 4.2 | CCCN(CCC)c1cc(N(C)c2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | ||
| 56659948 | 72273 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 388 | 8 | 1 | 7 | 4.5 | CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1830517 | 72273 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 388 | 8 | 1 | 7 | 4.5 | CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1077301 | 215270 | 0 | None | -8 | 3 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm990590f | ||||
| 22177924 | 71521 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 362 | 5 | 1 | 4 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4ccc(C)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL1819071 | 71521 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 362 | 5 | 1 | 4 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4ccc(C)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | ||
| 56663335 | 72079 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 415 | 10 | 1 | 6 | 5.7 | CCCc1c(Nc2ccc(OC)cc2Cl)nc2ccnn2c1N(CCC)CCC | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1828891 | 72079 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 415 | 10 | 1 | 6 | 5.7 | CCCc1c(Nc2ccc(OC)cc2Cl)nc2ccnn2c1N(CCC)CCC | 10.1016/j.bmc.2011.08.055 | ||
| 56663336 | 72084 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 387 | 8 | 0 | 6 | 4.8 | CCCN(CCC)c1cc(N(C)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| CHEMBL1828896 | 72084 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 387 | 8 | 0 | 6 | 4.8 | CCCN(CCC)c1cc(N(C)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | ||
| 9865575 | 210176 | 1 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 397 | 10 | 0 | 6 | 4.6 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | ||
| CHEMBL65484 | 210176 | 1 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 397 | 10 | 0 | 6 | 4.6 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | ||
| 9865575 | 210176 | 1 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 397 | 10 | 0 | 6 | 4.6 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | ||
| CHEMBL65484 | 210176 | 1 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 397 | 10 | 0 | 6 | 4.6 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | ||
| CHEMBL2370939 | 216742 | 0 | None | 5 | 2 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1CCC(=O)NNC(=O)C[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)[C@H](C)NC(=O)[C@@H](C)NC1=O)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm0202122 | ||||
| 10408534 | 82985 | 0 | None | - | 1 | Rat | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 397 | 5 | 0 | 5 | 5.1 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(C)c(OC)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058338 | 82985 | 0 | None | - | 1 | Rat | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 397 | 5 | 0 | 5 | 5.1 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(C)c(OC)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL1794009 | 215714 | 0 | None | -1 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@H](C)CC)[C@H](C)CC)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](C)NC1=O | 10.1021/jm0202122 | ||||
| 9979210 | 83062 | 0 | None | - | 1 | Rat | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 414 | 5 | 0 | 5 | 5.0 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(F)c(N(C)C)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058596 | 83062 | 0 | None | - | 1 | Rat | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 414 | 5 | 0 | 5 | 5.0 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(F)c(N(C)C)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL439883 | 220628 | 0 | None | -1 | 5 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm0202122 | ||||
| 44362115 | 7952 | 0 | None | 2 | 6 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm0202122 | ||||
| 6967 | 7952 | 0 | None | 2 | 6 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm0202122 | ||||
| CHEMBL1201609 | 7952 | 0 | None | 2 | 6 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm0202122 | ||||
| CHEMBL440057 | 7952 | 0 | None | 2 | 6 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | None | None | None | None | 10.1021/jm0202122 | ||||
| 44587375 | 200179 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 393 | 9 | 0 | 6 | 4.8 | CCCN(CCC)c1c(C)nc(-c2c(OC)cc(Cl)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | ||
| CHEMBL525716 | 200179 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 393 | 9 | 0 | 6 | 4.8 | CCCN(CCC)c1c(C)nc(-c2c(OC)cc(Cl)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | ||
| 70688491 | 83064 | 0 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 397 | 5 | 0 | 5 | 5.1 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(C)c(Cl)cc3OC)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058598 | 83064 | 0 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 397 | 5 | 0 | 5 | 5.1 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(C)c(Cl)cc3OC)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 44610627 | 146753 | 0 | None | -1 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 519 | 9 | 2 | 8 | 5.5 | Cc1cc(Nc2nc(Cl)cn([C@H](COC(=O)Nc3ccccc3)C3CC3)c2=O)c(C)nc1OC(F)F | 10.1016/j.bmcl.2016.03.067 | ||
| CHEMBL3799870 | 146753 | 0 | None | -1 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 519 | 9 | 2 | 8 | 5.5 | Cc1cc(Nc2nc(Cl)cn([C@H](COC(=O)Nc3ccccc3)C3CC3)c2=O)c(C)nc1OC(F)F | 10.1016/j.bmcl.2016.03.067 | ||
| 70690504 | 82858 | 0 | None | - | 1 | Rat | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 417 | 6 | 0 | 6 | 4.2 | COCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(F)c(OC)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2057479 | 82858 | 0 | None | - | 1 | Rat | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 417 | 6 | 0 | 6 | 4.2 | COCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(F)c(OC)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 70682137 | 83059 | 0 | None | - | 1 | Rat | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 401 | 5 | 0 | 5 | 4.9 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3cc(F)c(OC)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058593 | 83059 | 0 | None | - | 1 | Rat | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 401 | 5 | 0 | 5 | 4.9 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3cc(F)c(OC)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 45483574 | 204813 | 0 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 425 | 8 | 1 | 8 | 3.4 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C#N)c(OC(F)F)nc2C)c1=O | 10.1021/jm900716v | ||
| CHEMBL573978 | 204813 | 0 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 425 | 8 | 1 | 8 | 3.4 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C#N)c(OC(F)F)nc2C)c1=O | 10.1021/jm900716v | ||
| 44194976 | 202713 | 0 | None | -7 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 377 | 7 | 1 | 6 | 3.9 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | ||
| CHEMBL559437 | 202713 | 0 | None | -7 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 377 | 7 | 1 | 6 | 3.9 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | ||
| CHEMBL2370938 | 216741 | 0 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm0202122 | ||||
| 9884878 | 179804 | 18 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 352 | 6 | 1 | 5 | 4.9 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL45187 | 179804 | 18 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 352 | 6 | 1 | 5 | 4.9 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1016/j.bmc.2011.07.055 | ||
| CHEMBL2369741 | 216444 | 0 | None | -2 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC)NC(=O)[C@@H](C)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm0202122 | ||||
| 21984762 | 84317 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 409 | 8 | 0 | 4 | 5.9 | CCc1nn2c(-c3ccc(OC)cc3Cl)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | ||
| CHEMBL2087550 | 84317 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 409 | 8 | 0 | 4 | 5.9 | CCc1nn2c(-c3ccc(OC)cc3Cl)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | ||
| 21984648 | 84319 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 389 | 8 | 0 | 4 | 5.5 | CCc1nn2c(-c3ccc(C)cc3OC)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | ||
| CHEMBL2087552 | 84319 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 389 | 8 | 0 | 4 | 5.5 | CCc1nn2c(-c3ccc(C)cc3OC)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | ||
| 10378 | 10757 | 37 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | COc1ccc(c(c1)C)c1c(C)nn2c1nc(C)cc2N[C@H](c1onc(n1)C)CC | 10.1016/j.bmcl.2010.10.095 | ||
| 11596613 | 10757 | 37 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | COc1ccc(c(c1)C)c1c(C)nn2c1nc(C)cc2N[C@H](c1onc(n1)C)CC | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1287935 | 10757 | 37 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | COc1ccc(c(c1)C)c1c(C)nn2c1nc(C)cc2N[C@H](c1onc(n1)C)CC | 10.1016/j.bmcl.2010.10.095 | ||
| DB12512 | 10757 | 37 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | COc1ccc(c(c1)C)c1c(C)nn2c1nc(C)cc2N[C@H](c1onc(n1)C)CC | 10.1016/j.bmcl.2010.10.095 | ||
| 11509708 | 25764 | 3 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | CC[C@@H](Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12)c1nc(C)no1 | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1287905 | 25764 | 3 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | CC[C@@H](Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12)c1nc(C)no1 | 10.1016/j.bmcl.2010.10.095 | ||
| 58317452 | 133264 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 424 | 5 | 2 | 2 | 6.1 | CC(Nc1ccccc1)[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| CHEMBL3652065 | 133264 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 424 | 5 | 2 | 2 | 6.1 | CC(Nc1ccccc1)[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| 10044263 | 83066 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 363 | 5 | 0 | 5 | 4.4 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(OC)cc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058600 | 83066 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 363 | 5 | 0 | 5 | 4.4 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(OC)cc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 9820671 | 195597 | 0 | None | -6 | 2 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 369 | 6 | 1 | 7 | 3.9 | CC[C@@H](C)Nc1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | ||
| CHEMBL506214 | 195597 | 0 | None | -6 | 2 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 369 | 6 | 1 | 7 | 3.9 | CC[C@@H](C)Nc1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | ||
| 58801661 | 84340 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 495 | 11 | 0 | 8 | 4.8 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300259r | ||
| CHEMBL2087573 | 84340 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 495 | 11 | 0 | 8 | 4.8 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300259r | ||
| 53357662 | 133310 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 447 | 4 | 1 | 3 | 5.8 | Cc1nn(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c(C)c1Cl | nan | ||
| CHEMBL3652110 | 133310 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 447 | 4 | 1 | 3 | 5.8 | Cc1nn(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c(C)c1Cl | nan | ||
| 58317263 | 133306 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 435 | 4 | 1 | 3 | 5.7 | O=C(N[C@H]1CC[C@H](Cn2ncc3ccccc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652106 | 133306 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 435 | 4 | 1 | 3 | 5.7 | O=C(N[C@H]1CC[C@H](Cn2ncc3ccccc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 58398961 | 143111 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 431 | 4 | 1 | 4 | 4.6 | Cn1c(=O)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)ccc3Cl)CC2)c2ccccc21 | nan | ||
| CHEMBL3731086 | 143111 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 431 | 4 | 1 | 4 | 4.6 | Cn1c(=O)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)ccc3Cl)CC2)c2ccccc21 | nan | ||
| CHEMBL3734018 | 143111 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 431 | 4 | 1 | 4 | 4.6 | Cn1c(=O)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)ccc3Cl)CC2)c2ccccc21 | nan | ||
| 58317281 | 133299 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 415 | 5 | 3 | 4 | 4.2 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CNc2cc(C(F)(F)F)n[nH]2)CC1 | nan | ||
| CHEMBL3652099 | 133299 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 415 | 5 | 3 | 4 | 4.2 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CNc2cc(C(F)(F)F)n[nH]2)CC1 | nan | ||
| CHEMBL2369693 | 216426 | 0 | None | -1 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](C)NC1=O | 10.1021/jm0202122 | ||||
| 53308745 | 142352 | 0 | None | 67 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 441 | 4 | 1 | 3 | 4.6 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C3(CC3)c3cc(F)ccc32)CC1 | nan | ||
| CHEMBL3729075 | 142352 | 0 | None | 67 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 441 | 4 | 1 | 3 | 4.6 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C3(CC3)c3cc(F)ccc32)CC1 | nan | ||
| 44446725 | 175732 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 376 | 7 | 0 | 3 | 6.5 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2008.07.063 | ||
| CHEMBL438888 | 175732 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 376 | 7 | 0 | 3 | 6.5 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2008.07.063 | ||
| CHEMBL2370930 | 216738 | 0 | None | -1 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm0202122 | ||||
| 60155991 | 84354 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 515 | 12 | 0 | 9 | 4.8 | COCCN(CC1CCOCC1)c1c(SC)nn2c(-c3c(OC)cc(COC)cc3OC)cccc12 | 10.1021/jm300259r | ||
| CHEMBL2087801 | 84354 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 515 | 12 | 0 | 9 | 4.8 | COCCN(CC1CCOCC1)c1c(SC)nn2c(-c3c(OC)cc(COC)cc3OC)cccc12 | 10.1021/jm300259r | ||
| 59186840 | 133239 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 468 | 7 | 2 | 4 | 5.2 | CN(C)Cc1ccc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)nc1 | nan | ||
| CHEMBL3652040 | 133239 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 468 | 7 | 2 | 4 | 5.2 | CN(C)Cc1ccc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)nc1 | nan | ||
| 53341220 | 142354 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 444 | 4 | 1 | 2 | 5.6 | CC1(C)C(=O)N(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)ccc3Cl)CC2)c2ccccc21 | nan | ||
| CHEMBL3729078 | 142354 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 444 | 4 | 1 | 2 | 5.6 | CC1(C)C(=O)N(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)ccc3Cl)CC2)c2ccccc21 | nan | ||
| 10379 | 9833 | 39 | None | -1 | 3 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm900025h | ||
| 9884366 | 9833 | 39 | None | -1 | 3 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm900025h | ||
| CHEMBL482950 | 9833 | 39 | None | -1 | 3 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm900025h | ||
| DB12572 | 9833 | 39 | None | -1 | 3 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm900025h | ||
| 44621879 | 133269 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 443 | 5 | 2 | 3 | 5.6 | Cc1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)ncc1F | nan | ||
| CHEMBL3652070 | 133269 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 443 | 5 | 2 | 3 | 5.6 | Cc1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)ncc1F | nan | ||
| 70694747 | 83068 | 0 | None | - | 1 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 377 | 5 | 0 | 5 | 4.8 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3cc(C)c(OC)cc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058602 | 83068 | 0 | None | - | 1 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 377 | 5 | 0 | 5 | 4.8 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3cc(C)c(OC)cc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 70686533 | 83393 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 412 | 8 | 0 | 5 | 5.4 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(F)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2063381 | 83393 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 412 | 8 | 0 | 5 | 5.4 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(F)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 70686533 | 83393 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 412 | 8 | 0 | 5 | 5.4 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(F)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| CHEMBL2063381 | 83393 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 412 | 8 | 0 | 5 | 5.4 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(F)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| 44814766 | 133260 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 342 | 5 | 2 | 2 | 4.7 | O=C(N[C@H]1CC[C@H](CNc2ccccc2)CC1)c1cccc(Cl)c1 | nan | ||
| CHEMBL3652061 | 133260 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 342 | 5 | 2 | 2 | 4.7 | O=C(N[C@H]1CC[C@H](CNc2ccccc2)CC1)c1cccc(Cl)c1 | nan | ||
| 53341553 | 142798 | 0 | None | 331 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 459 | 4 | 1 | 3 | 5.3 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C(C)(C)c3ccc(Cl)cc32)CC1 | nan | ||
| CHEMBL3731783 | 142798 | 0 | None | 331 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 459 | 4 | 1 | 3 | 5.3 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C(C)(C)c3ccc(Cl)cc32)CC1 | nan | ||
| 44341743 | 117360 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 418 | 8 | 0 | 4 | 5.6 | COCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | ||
| CHEMBL325430 | 117360 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 418 | 8 | 0 | 4 | 5.6 | COCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | ||
| 44342075 | 174652 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 360 | 6 | 0 | 2 | 6.8 | CCCN(CCC)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)cccc12 | 10.1016/s0960-894x(03)00684-x | ||
| CHEMBL431076 | 174652 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 360 | 6 | 0 | 2 | 6.8 | CCCN(CCC)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)cccc12 | 10.1016/s0960-894x(03)00684-x | ||
| CHEMBL2370931 | 216739 | 0 | None | -2 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NC1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1021/jm0202122 | ||||
| 60155887 | 84348 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 465 | 9 | 0 | 7 | 5.0 | COc1cc(C)cc(OC)c1-c1cccc2c(N(CC3CCOCC3)CC3CC3)c(OC)nn12 | 10.1021/jm300259r | ||
| CHEMBL2087795 | 84348 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 465 | 9 | 0 | 7 | 5.0 | COc1cc(C)cc(OC)c1-c1cccc2c(N(CC3CCOCC3)CC3CC3)c(OC)nn12 | 10.1021/jm300259r | ||
| 58317445 | 131191 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 490 | 6 | 3 | 3 | 6.5 | Cc1n[nH]c(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1-c1ccccc1 | nan | ||
| CHEMBL3639509 | 131191 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 490 | 6 | 3 | 3 | 6.5 | Cc1n[nH]c(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1-c1ccccc1 | nan | ||
| 58317390 | 133311 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 427 | 4 | 1 | 3 | 5.5 | Cc1nn(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c(C)c1C | nan | ||
| CHEMBL3652111 | 133311 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 427 | 4 | 1 | 3 | 5.5 | Cc1nn(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c(C)c1C | nan | ||
| 59186797 | 133273 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 401 | 5 | 3 | 4 | 4.0 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CNc2n[nH]c3c2CCCC3)CC1 | nan | ||
| CHEMBL3652074 | 133273 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 401 | 5 | 3 | 4 | 4.0 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CNc2n[nH]c3c2CCCC3)CC1 | nan | ||
| 58398959 | 142675 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 466 | 4 | 1 | 5 | 4.4 | Cn1c(=O)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c2ncccc21 | nan | ||
| CHEMBL3731041 | 142675 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 466 | 4 | 1 | 5 | 4.4 | Cn1c(=O)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c2ncccc21 | nan | ||
| 53341428 | 142997 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 520 | 4 | 1 | 2 | 6.4 | O=C(N[C@H]1CC[C@H](CN2C(=O)C(F)(F)c3ccc(Cl)cc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3732979 | 142997 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 520 | 4 | 1 | 2 | 6.4 | O=C(N[C@H]1CC[C@H](CN2C(=O)C(F)(F)c3ccc(Cl)cc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 70696789 | 83056 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 425 | 6 | 0 | 5 | 5.9 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(C)c(OC(C)C)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058590 | 83056 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 425 | 6 | 0 | 5 | 5.9 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(C)c(OC(C)C)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 70686397 | 83069 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 378 | 5 | 0 | 6 | 4.1 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3cc(C)c(OC)nc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058603 | 83069 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 378 | 5 | 0 | 6 | 4.1 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3cc(C)c(OC)nc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 59186799 | 133289 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 510 | 6 | 3 | 3 | 6.8 | O=C(N[C@H]1CC[C@H](CNc2n[nH]cc2-c2ccc(Cl)cc2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652089 | 133289 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 510 | 6 | 3 | 3 | 6.8 | O=C(N[C@H]1CC[C@H](CNc2n[nH]cc2-c2ccc(Cl)cc2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 44342014 | 16315 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 392 | 6 | 0 | 5 | 4.7 | CCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| CHEMBL112290 | 16315 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 392 | 6 | 0 | 5 | 4.7 | CCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| 9909978 | 16810 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 418 | 8 | 0 | 4 | 6.7 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00621-8 | ||
| CHEMBL115142 | 16810 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 418 | 8 | 0 | 4 | 6.7 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00621-8 | ||
| 21984613 | 84318 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 389 | 8 | 0 | 4 | 5.5 | CCc1nn2c(-c3ccc(OC)cc3C)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | ||
| CHEMBL2087551 | 84318 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 389 | 8 | 0 | 4 | 5.5 | CCc1nn2c(-c3ccc(OC)cc3C)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | ||
| 10385822 | 82855 | 0 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 391 | 5 | 0 | 5 | 4.7 | CC[C@H](COC)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)nccc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2057476 | 82855 | 0 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 391 | 5 | 0 | 5 | 4.7 | CC[C@H](COC)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)nccc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 58317503 | 133302 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 475 | 6 | 2 | 4 | 5.8 | COc1ncc(Cl)cc1NC[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| CHEMBL3652102 | 133302 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 475 | 6 | 2 | 4 | 5.8 | COc1ncc(Cl)cc1NC[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| 53341600 | 142147 | 0 | None | 30 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 439 | 4 | 1 | 3 | 5.0 | Cc1cccc2c1C(C)(C)C(=O)N2C[C@H]1CC[C@H](NC(=O)c2cc(Cl)cnc2C)CC1 | nan | ||
| CHEMBL3727810 | 142147 | 0 | None | 30 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 439 | 4 | 1 | 3 | 5.0 | Cc1cccc2c1C(C)(C)C(=O)N2C[C@H]1CC[C@H](NC(=O)c2cc(Cl)cnc2C)CC1 | nan | ||
| 53341554 | 142510 | 0 | None | 19 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 467 | 4 | 1 | 3 | 5.1 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C(F)(F)c3ccc(Cl)cc32)CC1 | nan | ||
| CHEMBL3730045 | 142510 | 0 | None | 19 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 467 | 4 | 1 | 3 | 5.1 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C(F)(F)c3ccc(Cl)cc32)CC1 | nan | ||
| 67185290 | 133309 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 483 | 5 | 2 | 4 | 4.4 | Cc1cc(N2CCNC2=O)nn1C[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| CHEMBL3652109 | 133309 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 483 | 5 | 2 | 4 | 4.4 | Cc1cc(N2CCNC2=O)nn1C[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| 53341474 | 142794 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 482 | 4 | 1 | 2 | 5.9 | C[C@]1(F)C(=O)N(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c2ccccc21 | nan | ||
| CHEMBL3731745 | 142794 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 482 | 4 | 1 | 2 | 5.9 | C[C@]1(F)C(=O)N(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c2ccccc21 | nan | ||
| 62705998 | 82852 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 406 | 6 | 0 | 7 | 3.6 | CCC(COC)n1c(=O)c(C)nc2c(-c3cc(F)c(OC)cc3Cl)ncnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2057473 | 82852 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 406 | 6 | 0 | 7 | 3.6 | CCC(COC)n1c(=O)c(C)nc2c(-c3cc(F)c(OC)cc3Cl)ncnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 44341832 | 16190 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00621-8 | ||
| CHEMBL111665 | 16190 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00621-8 | ||
| 9952997 | 177382 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| CHEMBL445075 | 177382 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| 44341832 | 16190 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| CHEMBL111665 | 16190 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| 9908879 | 16852 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 398 | 6 | 0 | 2 | 7.1 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | ||
| CHEMBL115389 | 16852 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 398 | 6 | 0 | 2 | 7.1 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | ||
| 70696576 | 82358 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 438 | 11 | 0 | 6 | 6.1 | CCCN(CCC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| CHEMBL2046526 | 82358 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 438 | 11 | 0 | 6 | 6.1 | CCCN(CCC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| 70696576 | 82358 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 438 | 11 | 0 | 6 | 6.1 | CCCN(CCC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | ||
| CHEMBL2046526 | 82358 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 438 | 11 | 0 | 6 | 6.1 | CCCN(CCC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | ||
| 53341472 | 142169 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 508 | 5 | 1 | 3 | 6.0 | COc1ccc2c(c1)C(C)(C)C(=O)N2C[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| CHEMBL3727976 | 142169 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 508 | 5 | 1 | 3 | 6.0 | COc1ccc2c(c1)C(C)(C)C(=O)N2C[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| 60141295 | 82363 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 410 | 9 | 0 | 6 | 5.3 | CCN(CC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | ||
| CHEMBL2046534 | 82363 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 410 | 9 | 0 | 6 | 5.3 | CCN(CC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | ||
| 58398963 | 142959 | 0 | None | 54 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 459 | 4 | 1 | 3 | 5.3 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C(C)(C)c3cccc(Cl)c32)CC1 | nan | ||
| CHEMBL3732730 | 142959 | 0 | None | 54 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 459 | 4 | 1 | 3 | 5.3 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C(C)(C)c3cccc(Cl)c32)CC1 | nan | ||
| 59186812 | 133278 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 468 | 5 | 3 | 3 | 5.8 | O=C(N[C@H]1CC[C@H](CNc2n[nH]c3cccc(F)c23)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652079 | 133278 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 468 | 5 | 3 | 3 | 5.8 | O=C(N[C@H]1CC[C@H](CNc2n[nH]c3cccc(F)c23)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 9821586 | 174882 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | ||
| CHEMBL432800 | 174882 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | ||
| 70684375 | 83388 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 424 | 9 | 0 | 6 | 4.8 | COCCN(C)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| CHEMBL2063374 | 83388 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 424 | 9 | 0 | 6 | 4.8 | COCCN(C)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| 44816479 | 133259 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 470 | 7 | 2 | 3 | 5.8 | CN(Cc1cc(-c2ccccc2)n[nH]1)C[C@H]1CC[C@H](NC(=O)c2cc(Cl)ccc2Cl)CC1 | nan | ||
| CHEMBL3652060 | 133259 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 470 | 7 | 2 | 3 | 5.8 | CN(Cc1cc(-c2ccccc2)n[nH]1)C[C@H]1CC[C@H](NC(=O)c2cc(Cl)ccc2Cl)CC1 | nan | ||
| 58398949 | 142097 | 0 | None | 109 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 479 | 5 | 1 | 4 | 5.5 | CCn1c(=O)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c2ccccc21 | nan | ||
| CHEMBL3727515 | 142097 | 0 | None | 109 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 479 | 5 | 1 | 4 | 5.5 | CCn1c(=O)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c2ccccc21 | nan | ||
| 53341019 | 143018 | 0 | None | 16 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 454 | 6 | 1 | 5 | 4.8 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2c(=O)n(CC(C)C)c3ccccc32)CC1 | nan | ||
| CHEMBL3733118 | 143018 | 0 | None | 16 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 454 | 6 | 1 | 5 | 4.8 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2c(=O)n(CC(C)C)c3ccccc32)CC1 | nan | ||
| 44341739 | 120278 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 392 | 6 | 1 | 5 | 4.5 | CCCN(CCO)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| CHEMBL332040 | 120278 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 392 | 6 | 1 | 5 | 4.5 | CCCN(CCO)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| CHEMBL2368116 | 216366 | 0 | None | -43 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H](C(N)=O)[C@H](C)CC)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm0202122 | ||||
| 60155989 | 84352 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 513 | 11 | 0 | 9 | 4.5 | COCc1cc(OC)c(-c2cccc3c(N(CC4CC4)CC4COCCO4)c(SC)nn23)c(OC)c1 | 10.1021/jm300259r | ||
| CHEMBL2087799 | 84352 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 513 | 11 | 0 | 9 | 4.5 | COCc1cc(OC)c(-c2cccc3c(N(CC4CC4)CC4COCCO4)c(SC)nn23)c(OC)c1 | 10.1021/jm300259r | ||
| 145968888 | 171937 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 491 | 5 | 0 | 7 | 5.5 | COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc([C@H](OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | ||
| CHEMBL4228089 | 171937 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 491 | 5 | 0 | 7 | 5.5 | COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc([C@H](OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | ||
| 58317267 | 133313 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 414 | 4 | 1 | 4 | 4.6 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2nc(C(F)(F)F)cc2C)CC1 | nan | ||
| CHEMBL3652113 | 133313 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 414 | 4 | 1 | 4 | 4.6 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2nc(C(F)(F)F)cc2C)CC1 | nan | ||
| 44587456 | 194827 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 344 | 7 | 0 | 5 | 4.7 | CCC(CC)Oc1c(C)nc(-c2c(C)cc(C)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | ||
| CHEMBL497652 | 194827 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 344 | 7 | 0 | 5 | 4.7 | CCC(CC)Oc1c(C)nc(-c2c(C)cc(C)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | ||
| 44816314 | 133236 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 425 | 5 | 2 | 3 | 5.5 | Cc1ncccc1NC[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| CHEMBL3652037 | 133236 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 425 | 5 | 2 | 3 | 5.5 | Cc1ncccc1NC[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| 58317442 | 133285 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 459 | 5 | 2 | 3 | 6.1 | Cc1ncc(Cl)cc1NC[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| CHEMBL3652085 | 133285 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 459 | 5 | 2 | 3 | 6.1 | Cc1ncc(Cl)cc1NC[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| 59186841 | 133240 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 508 | 6 | 3 | 3 | 6.5 | C[C@@H]1C[C@@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC[C@@H]1CNc1cc(-c2ccc(F)cc2)[nH]n1 | nan | ||
| CHEMBL3652041 | 133240 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 508 | 6 | 3 | 3 | 6.5 | C[C@@H]1C[C@@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC[C@@H]1CNc1cc(-c2ccc(F)cc2)[nH]n1 | nan | ||
| 70696788 | 83054 | 0 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 411 | 6 | 0 | 5 | 5.5 | CCOc1cc(Cl)c(-c2ccnc3c2nc(C)c(=O)n3C(CC)C2CC2)cc1C | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058589 | 83054 | 0 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 411 | 6 | 0 | 5 | 5.5 | CCOc1cc(Cl)c(-c2ccnc3c2nc(C)c(=O)n3C(CC)C2CC2)cc1C | 10.1016/j.bmcl.2012.06.034 | ||
| 10069877 | 82857 | 0 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 405 | 6 | 0 | 6 | 4.2 | CCC(COC)n1c(=O)c(C)nc2c(-c3cc(F)c(OC)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2057478 | 82857 | 0 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 405 | 6 | 0 | 6 | 4.2 | CCC(COC)n1c(=O)c(C)nc2c(-c3cc(F)c(OC)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 60155709 | 84329 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 463 | 9 | 0 | 6 | 5.5 | CCc1nn2c(-c3c(OC)cc(C)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | ||
| CHEMBL2087562 | 84329 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 463 | 9 | 0 | 6 | 5.5 | CCc1nn2c(-c3c(OC)cc(C)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | ||
| 10200135 | 84322 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 385 | 8 | 0 | 4 | 5.9 | CCCN(CCC)c1c(CC)nn2c(-c3ccc(OC)cc3Cl)cccc12 | 10.1021/jm300259r | ||
| CHEMBL2087555 | 84322 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 385 | 8 | 0 | 4 | 5.9 | CCCN(CCC)c1c(CC)nn2c(-c3ccc(OC)cc3Cl)cccc12 | 10.1021/jm300259r | ||
| 127035055 | 142433 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 516 | 4 | 1 | 2 | 6.5 | C[C@@]1(F)C(=O)N(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c2cc(Cl)ccc21 | nan | ||
| CHEMBL3729578 | 142433 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 516 | 4 | 1 | 2 | 6.5 | C[C@@]1(F)C(=O)N(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c2cc(Cl)ccc21 | nan | ||
| 53341116 | 142587 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 484 | 4 | 1 | 2 | 5.9 | O=C(N[C@H]1CC[C@H](CN2C(=O)Cc3cc(Cl)ccc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3730505 | 142587 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 484 | 4 | 1 | 2 | 5.9 | O=C(N[C@H]1CC[C@H](CN2C(=O)Cc3cc(Cl)ccc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 10454889 | 82981 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 421 | 4 | 0 | 4 | 5.8 | CC[C@@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(C(F)(F)F)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058334 | 82981 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 421 | 4 | 0 | 4 | 5.8 | CC[C@@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(C(F)(F)F)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 44129684 | 171809 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 491 | 5 | 0 | 7 | 5.5 | COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc(C(OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | ||
| CHEMBL4226158 | 171809 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 491 | 5 | 0 | 7 | 5.5 | COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc(C(OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | ||
| 44815438 | 133242 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 439 | 5 | 2 | 3 | 5.8 | Cc1cc(C)nc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1 | nan | ||
| CHEMBL3652043 | 133242 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 439 | 5 | 2 | 3 | 5.8 | Cc1cc(C)nc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1 | nan | ||
| 71449705 | 88283 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(OC)c2nc(-c3c(Cl)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2160157 | 88283 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(OC)c2nc(-c3c(Cl)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 58317483 | 133255 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 413 | 4 | 1 | 3 | 5.2 | Cc1cc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | ||
| CHEMBL3652056 | 133255 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 413 | 4 | 1 | 3 | 5.2 | Cc1cc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | ||
| 58317373 | 133283 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 459 | 5 | 2 | 3 | 6.1 | Cc1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)ncc1Cl | nan | ||
| CHEMBL3652083 | 133283 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 459 | 5 | 2 | 3 | 6.1 | Cc1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)ncc1Cl | nan | ||
| 44816481 | 133263 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 425 | 5 | 2 | 3 | 5.5 | Cc1ccncc1NC[C@H]1CC[C@@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| CHEMBL3652064 | 133263 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 425 | 5 | 2 | 3 | 5.5 | Cc1ccncc1NC[C@H]1CC[C@@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| 70690704 | 83389 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 438 | 10 | 0 | 6 | 5.2 | CCN(CCOC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2063375 | 83389 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 438 | 10 | 0 | 6 | 5.2 | CCN(CCOC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 10255153 | 84334 | 8 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 493 | 11 | 0 | 7 | 5.4 | CCc1nn2c(-c3c(OC)cc(COC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | ||
| CHEMBL2087549 | 84334 | 8 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 493 | 11 | 0 | 7 | 5.4 | CCc1nn2c(-c3c(OC)cc(COC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | ||
| CHEMBL2087567 | 84334 | 8 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 493 | 11 | 0 | 7 | 5.4 | CCc1nn2c(-c3c(OC)cc(COC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | ||
| 70690704 | 83389 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 438 | 10 | 0 | 6 | 5.2 | CCN(CCOC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| CHEMBL2063375 | 83389 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 438 | 10 | 0 | 6 | 5.2 | CCN(CCOC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| 44816989 | 133268 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 429 | 5 | 2 | 3 | 5.3 | O=C(N[C@H]1CC[C@H](CNc2ccc(F)cn2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652069 | 133268 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 429 | 5 | 2 | 3 | 5.3 | O=C(N[C@H]1CC[C@H](CNc2ccc(F)cn2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 58317471 | 133312 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 461 | 5 | 1 | 3 | 6.2 | O=C(N[C@H]1CC[C@H](Cn2ccc(-c3ccccc3)n2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652112 | 133312 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 461 | 5 | 1 | 3 | 6.2 | O=C(N[C@H]1CC[C@H](Cn2ccc(-c3ccccc3)n2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 70686532 | 83386 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 408 | 8 | 0 | 5 | 5.5 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| CHEMBL2063372 | 83386 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 408 | 8 | 0 | 5 | 5.5 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| 62705994 | 83070 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 388 | 4 | 0 | 5 | 4.8 | CC[C@@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ncnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058604 | 83070 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 388 | 4 | 0 | 5 | 4.8 | CC[C@@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ncnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2369694 | 216427 | 0 | None | -4 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC)NC(=O)[C@@H](C)NC(=O)[C@H](CC(C)C)NC1=O | 10.1021/jm0202122 | ||||
| 53341430 | 143010 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 426 | 4 | 1 | 4 | 4.1 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C(C)(C)c3cccnc32)CC1 | nan | ||
| CHEMBL3733081 | 143010 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 426 | 4 | 1 | 4 | 4.1 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C(C)(C)c3cccnc32)CC1 | nan | ||
| 70690481 | 82680 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 429 | 6 | 1 | 4 | 6.6 | Cc1cc(C)c(Nc2nc3cccc(N(CC4CC4)C4CCOCC4)c3cc2C)c(C)c1 | 10.1016/j.bmcl.2012.05.066 | ||
| CHEMBL2049196 | 82680 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 429 | 6 | 1 | 4 | 6.6 | Cc1cc(C)c(Nc2nc3cccc(N(CC4CC4)C4CCOCC4)c3cc2C)c(C)c1 | 10.1016/j.bmcl.2012.05.066 | ||
| 71458702 | 88289 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 462 | 8 | 0 | 5 | 6.2 | CCN(CC)c1ccc(C(F)(F)F)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2160163 | 88289 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 462 | 8 | 0 | 5 | 6.2 | CCN(CC)c1ccc(C(F)(F)F)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 44816824 | 133267 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 429 | 5 | 2 | 3 | 5.3 | O=C(N[C@H]1CC[C@H](CNc2cncc(F)c2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652068 | 133267 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 429 | 5 | 2 | 3 | 5.3 | O=C(N[C@H]1CC[C@H](CNc2cncc(F)c2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL526149 | 222454 | 10 | None | -8 | 2 | Rat | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm9000242 | ||||
| 53340970 | 143011 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 427 | 5 | 1 | 6 | 3.6 | CCn1c(=O)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)c2ccncc21 | nan | ||
| CHEMBL3733082 | 143011 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 427 | 5 | 1 | 6 | 3.6 | CCn1c(=O)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)c2ccncc21 | nan | ||
| 53341118 | 142334 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 496 | 4 | 1 | 2 | 6.1 | CC1(C)C(=O)N(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c2ccc(F)cc21 | nan | ||
| CHEMBL3728921 | 142334 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 496 | 4 | 1 | 2 | 6.1 | CC1(C)C(=O)N(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c2ccc(F)cc21 | nan | ||
| 71455050 | 88287 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(Cl)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2160161 | 88287 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(Cl)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 58317277 | 133271 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 439 | 6 | 2 | 3 | 5.7 | CCc1cncc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1 | nan | ||
| CHEMBL3652072 | 133271 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 439 | 6 | 2 | 3 | 5.7 | CCc1cncc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1 | nan | ||
| 58317419 | 133284 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 464 | 5 | 2 | 4 | 5.6 | Cn1nc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c2ccccc21 | nan | ||
| CHEMBL3652084 | 133284 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 464 | 5 | 2 | 4 | 5.6 | Cn1nc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c2ccccc21 | nan | ||
| 58317366 | 133295 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 478 | 6 | 2 | 6 | 4.7 | O=C(N[C@H]1CC[C@H](CNc2nnnn2-c2ccccc2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652095 | 133295 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 478 | 6 | 2 | 6 | 4.7 | O=C(N[C@H]1CC[C@H](CNc2nnnn2-c2ccccc2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 58317417 | 133308 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 414 | 4 | 1 | 4 | 4.6 | Cc1nc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | ||
| CHEMBL3652108 | 133308 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 414 | 4 | 1 | 4 | 4.6 | Cc1nc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | ||
| 70684210 | 82856 | 0 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 375 | 5 | 0 | 5 | 4.4 | COc1ccc(-c2ccnc3c2nc(C)c(=O)n3C(C2CC2)C2CC2)c(C)c1 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2057477 | 82856 | 0 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 375 | 5 | 0 | 5 | 4.4 | COc1ccc(-c2ccnc3c2nc(C)c(=O)n3C(C2CC2)C2CC2)c(C)c1 | 10.1016/j.bmcl.2012.06.034 | ||
| 44341723 | 174912 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 416 | 7 | 0 | 4 | 6.3 | CCCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| CHEMBL432976 | 174912 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 416 | 7 | 0 | 4 | 6.3 | CCCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| 70686396 | 83065 | 0 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 413 | 6 | 0 | 6 | 4.8 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(Cl)c(OC)cc3OC)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058599 | 83065 | 0 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 413 | 6 | 0 | 6 | 4.8 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(Cl)c(OC)cc3OC)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2370929 | 216737 | 0 | None | -6 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm0202122 | ||||
| 10075105 | 84341 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 511 | 11 | 0 | 8 | 5.5 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(SC)nn23)c(OC)c1 | 10.1021/jm300259r | ||
| CHEMBL2087574 | 84341 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 511 | 11 | 0 | 8 | 5.5 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(SC)nn23)c(OC)c1 | 10.1021/jm300259r | ||
| CHEMBL1794007 | 215713 | 0 | None | 1 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@H](C)CC)[C@H](C)CC)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC1=O | 10.1021/jm0202122 | ||||
| 3663 | 106743 | 83 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 504 | 0 | 6 | 8 | 5.1 | Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 | 10.1021/np1000329 | ||
| CHEMBL286494 | 106743 | 83 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 504 | 0 | 6 | 8 | 5.1 | Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 | 10.1021/np1000329 | ||
| 58317349 | 133237 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 412 | 5 | 2 | 5 | 4.9 | Cc1nc(NC[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3Cl)CC2)sc1C | nan | ||
| CHEMBL3652038 | 133237 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 412 | 5 | 2 | 5 | 4.9 | Cc1nc(NC[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3Cl)CC2)sc1C | nan | ||
| 59186870 | 133270 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 454 | 5 | 3 | 3 | 5.4 | O=C(N[C@H]1CC[C@H](CNc2n[nH]c3c2CCCC3)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652071 | 133270 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 454 | 5 | 3 | 3 | 5.4 | O=C(N[C@H]1CC[C@H](CNc2n[nH]c3c2CCCC3)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 71458705 | 88296 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 438 | 10 | 0 | 6 | 5.5 | CCc1cc2c(N(CC)CC)ccc(OC)c2nc1-c1c(OC)cc(COC)cc1OC | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2160170 | 88296 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 438 | 10 | 0 | 6 | 5.5 | CCc1cc2c(N(CC)CC)ccc(OC)c2nc1-c1c(OC)cc(COC)cc1OC | 10.1016/j.bmc.2012.09.028 | ||
| 59186828 | 133282 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 480 | 6 | 3 | 4 | 5.6 | COc1ccc2c(NC[C@H]3CC[C@H](NC(=O)c4cc(C(F)(F)F)ccc4Cl)CC3)n[nH]c2c1 | nan | ||
| CHEMBL3652082 | 133282 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 480 | 6 | 3 | 4 | 5.6 | COc1ccc2c(NC[C@H]3CC[C@H](NC(=O)c4cc(C(F)(F)F)ccc4Cl)CC3)n[nH]c2c1 | nan | ||
| 44815273 | 133262 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 494 | 6 | 3 | 3 | 6.3 | O=C(N[C@H]1CC[C@@H](CNc2cc(-c3ccc(F)cc3)n[nH]2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652063 | 133262 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 494 | 6 | 3 | 3 | 6.3 | O=C(N[C@H]1CC[C@@H](CNc2cc(-c3ccc(F)cc3)n[nH]2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 71458704 | 88292 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 410 | 9 | 0 | 6 | 4.9 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)ccc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2160167 | 88292 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 410 | 9 | 0 | 6 | 4.9 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)ccc12 | 10.1016/j.bmc.2012.09.028 | ||
| 58317316 | 133307 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 435 | 4 | 1 | 3 | 5.7 | O=C(N[C@H]1CC[C@H](Cn2cc3ccccc3n2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652107 | 133307 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 435 | 4 | 1 | 3 | 5.7 | O=C(N[C@H]1CC[C@H](Cn2cc3ccccc3n2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 58317324 | 133303 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 448 | 5 | 3 | 3 | 5.4 | Cc1n[nH]c(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1Cl | nan | ||
| CHEMBL3652103 | 133303 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 448 | 5 | 3 | 3 | 5.4 | Cc1n[nH]c(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1Cl | nan | ||
| 70692691 | 82980 | 0 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 375 | 4 | 0 | 4 | 5.4 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(C)c(C)c(C)c3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058333 | 82980 | 0 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 375 | 4 | 0 | 4 | 5.4 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(C)c(C)c(C)c3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 44815603 | 133246 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 491 | 7 | 2 | 4 | 6.1 | O=C(N[C@H]1CC[C@H](CNCc2cc(-c3ccccc3)on2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652047 | 133246 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 491 | 7 | 2 | 4 | 6.1 | O=C(N[C@H]1CC[C@H](CNCc2cc(-c3ccccc3)on2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 53341473 | 142342 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 509 | 5 | 1 | 4 | 5.4 | COc1cc2c(cn1)C(C)(C)C(=O)N2C[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| CHEMBL3729005 | 142342 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 509 | 5 | 1 | 4 | 5.4 | COc1cc2c(cn1)C(C)(C)C(=O)N2C[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| 53357410 | 133316 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 360 | 4 | 1 | 4 | 3.8 | Cc1cc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)n1 | nan | ||
| CHEMBL3652116 | 133316 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 360 | 4 | 1 | 4 | 3.8 | Cc1cc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)n1 | nan | ||
| 9906984 | 82958 | 0 | None | - | 1 | Rat | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 361 | 3 | 0 | 4 | 4.7 | Cc1nc2c(-c3ccc(Cl)cc3Cl)ccnc2n(CC(C)C)c1=O | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058066 | 82958 | 0 | None | - | 1 | Rat | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 361 | 3 | 0 | 4 | 4.7 | Cc1nc2c(-c3ccc(Cl)cc3Cl)ccnc2n(CC(C)C)c1=O | 10.1016/j.bmcl.2012.06.034 | ||
| 42618197 | 191085 | 0 | None | -5 | 2 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 391 | 6 | 1 | 6 | 4.8 | CCC(CC)Nc1nc(C)nc2c(-c3cc(F)c(OC)cc3Cl)c(C)nn12 | 10.1021/jm9000242 | ||
| CHEMBL484158 | 191085 | 0 | None | -5 | 2 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 391 | 6 | 1 | 6 | 4.8 | CCC(CC)Nc1nc(C)nc2c(-c3cc(F)c(OC)cc3Cl)c(C)nn12 | 10.1021/jm9000242 | ||
| 71458703 | 88290 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 419 | 8 | 0 | 6 | 5.1 | CCN(CC)c1ccc(C#N)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2160164 | 88290 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 419 | 8 | 0 | 6 | 5.1 | CCN(CC)c1ccc(C#N)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 44815437 | 133241 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 431 | 5 | 2 | 4 | 5.5 | Cc1cnc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)s1 | nan | ||
| CHEMBL3652042 | 133241 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 431 | 5 | 2 | 4 | 5.5 | Cc1cnc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)s1 | nan | ||
| 12086065 | 17607 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 406 | 7 | 0 | 5 | 5.1 | CCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| CHEMBL117209 | 17607 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 406 | 7 | 0 | 5 | 5.1 | CCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| 9908466 | 121582 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | ||
| CHEMBL334039 | 121582 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | ||
| 53341173 | 142085 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 465 | 4 | 1 | 4 | 5.0 | Cn1c(=O)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c2ccccc21 | nan | ||
| CHEMBL3727446 | 142085 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 465 | 4 | 1 | 4 | 5.0 | Cn1c(=O)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c2ccccc21 | nan | ||
| 62705997 | 82851 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 376 | 5 | 0 | 6 | 3.8 | COc1ccc(-c2ncnc3c2nc(C)c(=O)n3C(C2CC2)C2CC2)c(C)c1 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2057472 | 82851 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 376 | 5 | 0 | 6 | 3.8 | COc1ccc(-c2ncnc3c2nc(C)c(=O)n3C(C2CC2)C2CC2)c(C)c1 | 10.1016/j.bmcl.2012.06.034 | ||
| 59186851 | 133288 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 490 | 6 | 3 | 3 | 6.5 | Cc1c(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n[nH]c1-c1ccccc1 | nan | ||
| CHEMBL3652088 | 133288 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 490 | 6 | 3 | 3 | 6.5 | Cc1c(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n[nH]c1-c1ccccc1 | nan | ||
| 59186801 | 133298 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 477 | 6 | 3 | 4 | 5.5 | O=C(N[C@H]1CC[C@H](CNc2[nH]ncc2-c2cccnc2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652098 | 133298 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 477 | 6 | 3 | 4 | 5.5 | O=C(N[C@H]1CC[C@H](CNc2[nH]ncc2-c2cccnc2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 70688432 | 82677 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 375 | 7 | 1 | 3 | 6.8 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | ||
| CHEMBL2049193 | 82677 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 375 | 7 | 1 | 3 | 6.8 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | ||
| 70696935 | 83384 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 450 | 11 | 0 | 5 | 6.6 | CCCN(CCC)c1ccc(CC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| CHEMBL2063370 | 83384 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 450 | 11 | 0 | 5 | 6.6 | CCCN(CCC)c1ccc(CC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| 53341596 | 142440 | 0 | None | 79 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 455 | 5 | 1 | 4 | 4.7 | COc1ccc2c(c1)N(C[C@H]1CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC1)C(=O)C2(C)C | nan | ||
| CHEMBL3729602 | 142440 | 0 | None | 79 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 455 | 5 | 1 | 4 | 4.7 | COc1ccc2c(c1)N(C[C@H]1CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC1)C(=O)C2(C)C | nan | ||
| 42618195 | 191065 | 0 | None | 1 | 2 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 413 | 9 | 0 | 8 | 3.1 | COCCN(CCOC)c1nc(C)nc2c(-c3cc(C)c(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | ||
| CHEMBL483993 | 191065 | 0 | None | 1 | 2 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 413 | 9 | 0 | 8 | 3.1 | COCCN(CCOC)c1nc(C)nc2c(-c3cc(C)c(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | ||
| 62705996 | 83072 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 434 | 6 | 0 | 6 | 5.1 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(Cl)c(OC(F)F)cc3C)ncnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058606 | 83072 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 434 | 6 | 0 | 6 | 5.1 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(Cl)c(OC(F)F)cc3C)ncnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 44814573 | 133235 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 425 | 5 | 2 | 3 | 5.5 | Cc1cccnc1NC[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| CHEMBL3652036 | 133235 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 425 | 5 | 2 | 3 | 5.5 | Cc1cccnc1NC[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| 58317295 | 133290 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 406 | 5 | 2 | 4 | 4.8 | Cc1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)ncc1Cl | nan | ||
| CHEMBL3652090 | 133290 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 406 | 5 | 2 | 4 | 4.8 | Cc1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)ncc1Cl | nan | ||
| 44341814 | 117441 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 0 | 6 | 4.4 | COCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| CHEMBL325918 | 117441 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 0 | 6 | 4.4 | COCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| 22052143 | 82959 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 375 | 3 | 0 | 4 | 5.3 | Cc1nc2c(-c3ccc(Cl)cc3Cl)ccnc2n(C(C)C(C)C)c1=O | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058067 | 82959 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 375 | 3 | 0 | 4 | 5.3 | Cc1nc2c(-c3ccc(Cl)cc3Cl)ccnc2n(C(C)C(C)C)c1=O | 10.1016/j.bmcl.2012.06.034 | ||
| 70682294 | 83392 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 394 | 8 | 0 | 5 | 5.2 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)ccc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2063380 | 83392 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 394 | 8 | 0 | 5 | 5.2 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)ccc12 | 10.1016/j.bmc.2012.09.028 | ||
| 70682294 | 83392 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 394 | 8 | 0 | 5 | 5.2 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)ccc12 | 10.1016/j.bmcl.2012.07.047 | ||
| CHEMBL2063380 | 83392 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 394 | 8 | 0 | 5 | 5.2 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)ccc12 | 10.1016/j.bmcl.2012.07.047 | ||
| 60155888 | 84349 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 481 | 9 | 0 | 7 | 5.7 | COc1cc(C)cc(OC)c1-c1cccc2c(N(CC3CCOCC3)CC3CC3)c(SC)nn12 | 10.1021/jm300259r | ||
| CHEMBL2087796 | 84349 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 481 | 9 | 0 | 7 | 5.7 | COc1cc(C)cc(OC)c1-c1cccc2c(N(CC3CCOCC3)CC3CC3)c(SC)nn12 | 10.1021/jm300259r | ||
| 59186815 | 133244 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 425 | 5 | 2 | 3 | 5.5 | Cc1cccc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | ||
| CHEMBL3652045 | 133244 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 425 | 5 | 2 | 3 | 5.5 | Cc1cccc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | ||
| 3520 | 10041 | 54 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm300864p | ||
| 9821250 | 10041 | 54 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm300864p | ||
| CHEMBL309138 | 10041 | 54 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm300864p | ||
| 9977800 | 82975 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 391 | 5 | 0 | 5 | 4.7 | CC[C@H](COC)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058329 | 82975 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 391 | 5 | 0 | 5 | 4.7 | CC[C@H](COC)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 10339953 | 82983 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 383 | 5 | 0 | 5 | 4.8 | CC[C@@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(OC)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058336 | 82983 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 383 | 5 | 0 | 5 | 4.8 | CC[C@@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(OC)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 22052073 | 82973 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 401 | 5 | 0 | 4 | 5.8 | CCCC(C1CC1)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058327 | 82973 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 401 | 5 | 0 | 4 | 5.8 | CCCC(C1CC1)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 57786006 | 171742 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 422 | 4 | 0 | 4 | 6.4 | CCN(CC)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | ||
| CHEMBL4225254 | 171742 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 422 | 4 | 0 | 4 | 6.4 | CCN(CC)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | ||
| 10362573 | 82984 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 383 | 5 | 0 | 5 | 4.8 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(OC)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058337 | 82984 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 383 | 5 | 0 | 5 | 4.8 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(OC)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 70694746 | 83057 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 397 | 5 | 0 | 5 | 5.1 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3cc(Cl)c(OC)cc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058591 | 83057 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 397 | 5 | 0 | 5 | 5.1 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3cc(Cl)c(OC)cc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 70682138 | 83063 | 0 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 392 | 4 | 0 | 5 | 5.0 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(C#N)c(C)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058597 | 83063 | 0 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 392 | 4 | 0 | 5 | 5.0 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(C#N)c(C)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 44194975 | 203089 | 16 | None | -4 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 423 | 6 | 1 | 5 | 5.5 | C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1021/jm900302q | ||
| CHEMBL562219 | 203089 | 16 | None | -4 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 423 | 6 | 1 | 5 | 5.5 | C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1021/jm900302q | ||
| 44816316 | 133258 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 425 | 5 | 2 | 3 | 5.5 | Cc1cncc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1 | nan | ||
| CHEMBL3652059 | 133258 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 425 | 5 | 2 | 3 | 5.5 | Cc1cncc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1 | nan | ||
| 53340971 | 142124 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 427 | 4 | 1 | 6 | 3.4 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2c(=O)n(C)c3nccc(C)c32)CC1 | nan | ||
| CHEMBL3727694 | 142124 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 427 | 4 | 1 | 6 | 3.4 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2c(=O)n(C)c3nccc(C)c32)CC1 | nan | ||
| 71456848 | 88285 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 394 | 7 | 0 | 5 | 5.4 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(C)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2160159 | 88285 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 394 | 7 | 0 | 5 | 5.4 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(C)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 59186833 | 133305 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 442 | 6 | 3 | 3 | 5.4 | CCc1[nH]nc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1C | nan | ||
| CHEMBL3652105 | 133305 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 442 | 6 | 3 | 3 | 5.4 | CCc1[nH]nc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1C | nan | ||
| 53340926 | 142553 | 0 | None | 19 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 463 | 4 | 1 | 3 | 5.2 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C(C)(F)c3ccc(Cl)cc32)CC1 | nan | ||
| CHEMBL3730298 | 142553 | 0 | None | 19 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 463 | 4 | 1 | 3 | 5.2 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C(C)(F)c3ccc(Cl)cc32)CC1 | nan | ||
| 53341018 | 142722 | 0 | None | 5 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 426 | 5 | 1 | 5 | 4.2 | CCn1c(=O)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)c2ccccc21 | nan | ||
| CHEMBL3731280 | 142722 | 0 | None | 5 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 426 | 5 | 1 | 5 | 4.2 | CCn1c(=O)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)c2ccccc21 | nan | ||
| 11948286 | 163448 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 410 | 5 | 0 | 3 | 7.5 | CCC(CC)c1ccc(Cl)c2nc(Oc3c(C)cc(Cl)cc3Cl)n(C)c12 | 10.1016/j.bmc.2016.11.011 | ||
| CHEMBL4069551 | 163448 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 410 | 5 | 0 | 3 | 7.5 | CCC(CC)c1ccc(Cl)c2nc(Oc3c(C)cc(Cl)cc3Cl)n(C)c12 | 10.1016/j.bmc.2016.11.011 | ||
| 70684376 | 83394 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(Cl)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2063382 | 83394 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(Cl)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 70684376 | 83394 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(Cl)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| CHEMBL2063382 | 83394 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(Cl)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| CHEMBL2370917 | 216731 | 0 | None | -34 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm0202122 | ||||
| 70692846 | 83387 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 460 | 10 | 0 | 5 | 6.3 | COCc1cc(OC)c(-c2nc3c(C)ccc(N(CC4CC4)CC4CC4)c3cc2C)c(OC)c1 | 10.1016/j.bmcl.2012.07.047 | ||
| CHEMBL2063373 | 83387 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 460 | 10 | 0 | 5 | 6.3 | COCc1cc(OC)c(-c2nc3c(C)ccc(N(CC4CC4)CC4CC4)c3cc2C)c(OC)c1 | 10.1016/j.bmcl.2012.07.047 | ||
| 70692631 | 82675 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 378 | 7 | 2 | 4 | 5.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)[nH]c12 | 10.1016/j.bmcl.2012.05.066 | ||
| CHEMBL2049190 | 82675 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 378 | 7 | 2 | 4 | 5.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)[nH]c12 | 10.1016/j.bmcl.2012.05.066 | ||
| 53341117 | 142885 | 0 | None | 83 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 468 | 4 | 1 | 2 | 5.4 | O=C(N[C@H]1CC[C@H](CN2C(=O)Cc3ccc(F)cc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3732322 | 142885 | 0 | None | 83 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 468 | 4 | 1 | 2 | 5.4 | O=C(N[C@H]1CC[C@H](CN2C(=O)Cc3ccc(F)cc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 44815110 | 133256 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 440 | 6 | 3 | 3 | 5.4 | O=C(N[C@H]1CC[C@H](CNc2cc(C3CC3)n[nH]2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652057 | 133256 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 440 | 6 | 3 | 3 | 5.4 | O=C(N[C@H]1CC[C@H](CNc2cc(C3CC3)n[nH]2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 53341427 | 142122 | 0 | None | 79 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 425 | 4 | 1 | 3 | 4.7 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C(C)(C)c3ccccc32)CC1 | nan | ||
| CHEMBL3727689 | 142122 | 0 | None | 79 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 425 | 4 | 1 | 3 | 4.7 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C(C)(C)c3ccccc32)CC1 | nan | ||
| 21984746 | 84323 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 365 | 8 | 0 | 4 | 5.5 | CCCN(CCC)c1c(CC)nn2c(-c3ccc(OC)cc3C)cccc12 | 10.1021/jm300259r | ||
| CHEMBL2087556 | 84323 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 365 | 8 | 0 | 4 | 5.5 | CCCN(CCC)c1c(CC)nn2c(-c3ccc(OC)cc3C)cccc12 | 10.1021/jm300259r | ||
| 9952997 | 177382 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00621-8 | ||
| CHEMBL445075 | 177382 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00621-8 | ||
| 9909978 | 16810 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 418 | 8 | 0 | 4 | 6.7 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| CHEMBL115142 | 16810 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 418 | 8 | 0 | 4 | 6.7 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | ||
| 70696779 | 82979 | 0 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 361 | 4 | 0 | 4 | 5.1 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(C)c(C)cc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058332 | 82979 | 0 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 361 | 4 | 0 | 4 | 5.1 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(C)c(C)cc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2370933 | 216740 | 0 | None | -9 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(CC(=O)O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm0202122 | ||||
| 53341556 | 142373 | 0 | None | 33 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 508 | 5 | 1 | 3 | 6.0 | COc1cccc2c1N(C[C@H]1CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC1)C(=O)C2(C)C | nan | ||
| CHEMBL3729197 | 142373 | 0 | None | 33 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 508 | 5 | 1 | 3 | 6.0 | COc1cccc2c1N(C[C@H]1CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC1)C(=O)C2(C)C | nan | ||
| 58801647 | 84342 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 479 | 10 | 0 | 7 | 5.1 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(C)nn23)c(OC)c1 | 10.1021/jm300259r | ||
| CHEMBL2087575 | 84342 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 479 | 10 | 0 | 7 | 5.1 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(C)nn23)c(OC)c1 | 10.1021/jm300259r | ||
| 59186865 | 133252 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 410 | 5 | 2 | 2 | 5.8 | O=C(N[C@H]1CC[C@H](CNc2ccccc2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652053 | 133252 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 410 | 5 | 2 | 2 | 5.8 | O=C(N[C@H]1CC[C@H](CNc2ccccc2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 44815774 | 133257 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 428 | 5 | 2 | 2 | 5.9 | O=C(N[C@H]1CC[C@H](CNc2cccc(F)c2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652058 | 133257 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 428 | 5 | 2 | 2 | 5.9 | O=C(N[C@H]1CC[C@H](CNc2cccc(F)c2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 3520 | 10041 | 54 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm050384+ | ||
| 9821250 | 10041 | 54 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm050384+ | ||
| CHEMBL309138 | 10041 | 54 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm050384+ | ||
| 59186804 | 133265 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 424 | 5 | 2 | 2 | 6.0 | C[C@H]1CC(CNc2ccccc2)CCC1NC(=O)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652066 | 133265 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 424 | 5 | 2 | 2 | 6.0 | C[C@H]1CC(CNc2ccccc2)CCC1NC(=O)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 44341636 | 16467 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | ||
| CHEMBL113097 | 16467 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | ||
| 60155540 | 84347 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 490 | 10 | 0 | 8 | 4.7 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(C#N)nn23)c(OC)c1 | 10.1021/jm300259r | ||
| CHEMBL2087794 | 84347 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 490 | 10 | 0 | 8 | 4.7 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(C#N)nn23)c(OC)c1 | 10.1021/jm300259r | ||
| 70688490 | 83061 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 385 | 5 | 0 | 5 | 4.4 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(F)c(OC)cc3F)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058595 | 83061 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 385 | 5 | 0 | 5 | 4.4 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(F)c(OC)cc3F)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 58317486 | 133294 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 475 | 6 | 2 | 4 | 5.8 | COc1ccc(Cl)c(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | ||
| CHEMBL3652094 | 133294 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 475 | 6 | 2 | 4 | 5.8 | COc1ccc(Cl)c(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | ||
| 59186805 | 133280 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 464 | 5 | 3 | 3 | 5.9 | Cc1cccc2[nH]nc(NC[C@H]3CC[C@H](NC(=O)c4cc(C(F)(F)F)ccc4Cl)CC3)c12 | nan | ||
| CHEMBL3652080 | 133280 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 464 | 5 | 3 | 3 | 5.9 | Cc1cccc2[nH]nc(NC[C@H]3CC[C@H](NC(=O)c4cc(C(F)(F)F)ccc4Cl)CC3)c12 | nan | ||
| 59186875 | 133286 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 465 | 5 | 3 | 4 | 5.3 | Cc1ccc2c(NC[C@H]3CC[C@H](NC(=O)c4cc(C(F)(F)F)ccc4Cl)CC3)n[nH]c2n1 | nan | ||
| CHEMBL3652086 | 133286 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 465 | 5 | 3 | 4 | 5.3 | Cc1ccc2c(NC[C@H]3CC[C@H](NC(=O)c4cc(C(F)(F)F)ccc4Cl)CC3)n[nH]c2n1 | nan | ||
| 58317325 | 133314 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 459 | 5 | 2 | 3 | 6.1 | Cc1ncc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)cc1Cl | nan | ||
| CHEMBL3652114 | 133314 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 459 | 5 | 2 | 3 | 6.1 | Cc1ncc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)cc1Cl | nan | ||
| 145969226 | 171776 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 491 | 5 | 0 | 7 | 5.5 | COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc([C@@H](OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | ||
| CHEMBL4225709 | 171776 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 491 | 5 | 0 | 7 | 5.5 | COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc([C@@H](OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | ||
| 11740957 | 82854 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 387 | 4 | 0 | 4 | 5.4 | CC[C@@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)nccc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2057475 | 82854 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 387 | 4 | 0 | 4 | 5.4 | CC[C@@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)nccc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 70692630 | 82673 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 376 | 7 | 1 | 4 | 6.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)nc12 | 10.1016/j.bmcl.2012.05.066 | ||
| CHEMBL2049188 | 82673 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 376 | 7 | 1 | 4 | 6.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)nc12 | 10.1016/j.bmcl.2012.05.066 | ||
| 53341597 | 142074 | 0 | None | 37 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 492 | 4 | 1 | 2 | 6.3 | Cc1cccc2c1N(C[C@H]1CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC1)C(=O)C2(C)C | nan | ||
| CHEMBL3727391 | 142074 | 0 | None | 37 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 492 | 4 | 1 | 2 | 6.3 | Cc1cccc2c1N(C[C@H]1CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC1)C(=O)C2(C)C | nan | ||
| 71453344 | 88294 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 444 | 9 | 0 | 6 | 5.6 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(Cl)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2160169 | 88294 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 444 | 9 | 0 | 6 | 5.6 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(Cl)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 59186854 | 133291 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 524 | 6 | 3 | 3 | 7.1 | Cc1[nH]nc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1-c1ccc(Cl)cc1 | nan | ||
| CHEMBL3652091 | 133291 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 524 | 6 | 3 | 3 | 7.1 | Cc1[nH]nc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1-c1ccc(Cl)cc1 | nan | ||
| 53358726 | 133266 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 374 | 4 | 1 | 4 | 4.2 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2nc(C)c(C)c2C)CC1 | nan | ||
| CHEMBL3652067 | 133266 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 374 | 4 | 1 | 4 | 4.2 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2nc(C)c(C)c2C)CC1 | nan | ||
| 53341068 | 142901 | 0 | None | 77 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 457 | 4 | 1 | 3 | 5.2 | Cc1cc2c(cc1C)C(C)(F)C(=O)N2C[C@H]1CC[C@H](NC(=O)c2cc(Cl)cnc2C)CC1 | nan | ||
| CHEMBL3732415 | 142901 | 0 | None | 77 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 457 | 4 | 1 | 3 | 5.2 | Cc1cc2c(cc1C)C(C)(F)C(=O)N2C[C@H]1CC[C@H](NC(=O)c2cc(Cl)cnc2C)CC1 | nan | ||
| 21984771 | 84320 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 403 | 8 | 0 | 4 | 5.8 | CCc1nn2c(-c3c(C)cc(C)cc3OC)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | ||
| CHEMBL2087553 | 84320 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 403 | 8 | 0 | 4 | 5.8 | CCc1nn2c(-c3c(C)cc(C)cc3OC)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | ||
| 59186844 | 133293 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 476 | 6 | 3 | 3 | 6.2 | O=C(N[C@H]1CC[C@H](CNc2n[nH]cc2-c2ccccc2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652093 | 133293 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 476 | 6 | 3 | 3 | 6.2 | O=C(N[C@H]1CC[C@H](CNc2n[nH]cc2-c2ccccc2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 58317306 | 133304 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 524 | 6 | 2 | 4 | 6.9 | Cc1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n(-c2ccc(Cl)cc2)n1 | nan | ||
| CHEMBL3652104 | 133304 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 524 | 6 | 2 | 4 | 6.9 | Cc1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n(-c2ccc(Cl)cc2)n1 | nan | ||
| 53341068 | 142901 | 0 | None | 77 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 457 | 4 | 1 | 3 | 5.2 | Cc1cc2c(cc1C)C(C)(F)C(=O)N2C[C@H]1CC[C@H](NC(=O)c2cc(Cl)cnc2C)CC1 | nan | ||
| CHEMBL3732415 | 142901 | 0 | None | 77 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 457 | 4 | 1 | 3 | 5.2 | Cc1cc2c(cc1C)C(C)(F)C(=O)N2C[C@H]1CC[C@H](NC(=O)c2cc(Cl)cnc2C)CC1 | nan | ||
| 59186847 | 133247 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 445 | 5 | 2 | 4 | 5.8 | Cc1nc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)sc1C | nan | ||
| CHEMBL3652048 | 133247 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 445 | 5 | 2 | 4 | 5.8 | Cc1nc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)sc1C | nan | ||
| 44815273 | 133248 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 494 | 6 | 3 | 3 | 6.3 | O=C(N[C@H]1CC[C@H](CNc2cc(-c3ccc(F)cc3)n[nH]2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652049 | 133248 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 494 | 6 | 3 | 3 | 6.3 | O=C(N[C@H]1CC[C@H](CNc2cc(-c3ccc(F)cc3)n[nH]2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 59186813 | 133249 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 442 | 7 | 3 | 3 | 5.4 | CCCc1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n[nH]1 | nan | ||
| CHEMBL3652050 | 133249 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 442 | 7 | 3 | 3 | 5.4 | CCCc1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n[nH]1 | nan | ||
| 53341066 | 142379 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 459 | 4 | 1 | 3 | 5.0 | Cc1ncc(C(F)(F)F)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C(C)(C)c3ccccc32)CC1 | nan | ||
| CHEMBL3729224 | 142379 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 459 | 4 | 1 | 3 | 5.0 | Cc1ncc(C(F)(F)F)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)C(C)(C)c3ccccc32)CC1 | nan | ||
| 53341558 | 142893 | 0 | None | 74 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 429 | 4 | 1 | 3 | 4.6 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)[C@@](C)(F)c3ccccc32)CC1 | nan | ||
| CHEMBL3732369 | 142893 | 0 | None | 74 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 429 | 4 | 1 | 3 | 4.6 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CN2C(=O)[C@@](C)(F)c3ccccc32)CC1 | nan | ||
| 22052205 | 82960 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 375 | 4 | 0 | 4 | 5.4 | CCCC(C)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058068 | 82960 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 375 | 4 | 0 | 4 | 5.4 | CCCC(C)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 59186819 | 133272 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 390 | 5 | 2 | 4 | 4.3 | Cc1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)ncc1F | nan | ||
| CHEMBL3652073 | 133272 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 390 | 5 | 2 | 4 | 4.3 | Cc1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)ncc1F | nan | ||
| 59186796 | 133281 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 484 | 5 | 3 | 3 | 6.3 | O=C(N[C@H]1CC[C@H](CNc2n[nH]c3ccc(Cl)cc23)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652081 | 133281 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 484 | 5 | 3 | 3 | 6.3 | O=C(N[C@H]1CC[C@H](CNc2n[nH]c3ccc(Cl)cc23)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 71451515 | 88284 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 405 | 7 | 0 | 6 | 5.0 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(C#N)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2160158 | 88284 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 405 | 7 | 0 | 6 | 5.0 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(C#N)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 22052069 | 82974 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 377 | 4 | 0 | 5 | 4.3 | COCC(C)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058328 | 82974 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 377 | 4 | 0 | 5 | 4.3 | COCC(C)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 59186871 | 133245 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 444 | 5 | 2 | 2 | 6.4 | O=C(N[C@H]1CC[C@H](CNc2ccccc2Cl)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652046 | 133245 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 444 | 5 | 2 | 2 | 6.4 | O=C(N[C@H]1CC[C@H](CNc2ccccc2Cl)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 44815276 | 133250 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 442 | 6 | 3 | 3 | 5.6 | CC(C)c1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n[nH]1 | nan | ||
| CHEMBL3652051 | 133250 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 442 | 6 | 3 | 3 | 5.6 | CC(C)c1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n[nH]1 | nan | ||
| 67238091 | 133238 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 455 | 6 | 3 | 4 | 4.9 | O=C(O)c1ccc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)nc1 | nan | ||
| CHEMBL3652039 | 133238 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 455 | 6 | 3 | 4 | 4.9 | O=C(O)c1ccc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)nc1 | nan | ||
| 53341425 | 142730 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 484 | 4 | 1 | 2 | 5.9 | O=C(N[C@H]1CC[C@H](CN2C(=O)Cc3ccc(Cl)cc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3731360 | 142730 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 484 | 4 | 1 | 2 | 5.9 | O=C(N[C@H]1CC[C@H](CN2C(=O)Cc3ccc(Cl)cc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 71455053 | 88299 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 482 | 12 | 0 | 7 | 5.5 | COCCN(CC(C)C)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2160173 | 88299 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 482 | 12 | 0 | 7 | 5.5 | COCCN(CC(C)C)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 9908904 | 187266 | 4 | None | -5 | 2 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | ||
| CHEMBL474287 | 187266 | 4 | None | -5 | 2 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | ||
| CHEMBL475306 | 187266 | 4 | None | -5 | 2 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | ||
| 44815440 | 133243 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 425 | 5 | 2 | 3 | 5.5 | Cc1ccc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)nc1 | nan | ||
| CHEMBL3652044 | 133243 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 425 | 5 | 2 | 3 | 5.5 | Cc1ccc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)nc1 | nan | ||
| 58317463 | 133253 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 392 | 5 | 2 | 5 | 4.5 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CNc2nc(C)c(C)s2)CC1 | nan | ||
| CHEMBL3652054 | 133253 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 392 | 5 | 2 | 5 | 4.5 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CNc2nc(C)c(C)s2)CC1 | nan | ||
| 71453343 | 88286 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 412 | 8 | 0 | 5 | 5.4 | CCN(CC)c1ccc(F)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2160160 | 88286 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 412 | 8 | 0 | 5 | 5.4 | CCN(CC)c1ccc(F)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 59186843 | 133292 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 451 | 5 | 3 | 4 | 5.0 | O=C(N[C@H]1CC[C@H](CNc2n[nH]c3cccnc23)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652092 | 133292 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 451 | 5 | 3 | 4 | 5.0 | O=C(N[C@H]1CC[C@H](CNc2n[nH]c3cccnc23)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 58317395 | 133296 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 490 | 6 | 2 | 4 | 6.2 | Cn1cc(-c2ccccc2)c(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | ||
| CHEMBL3652096 | 133296 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 490 | 6 | 2 | 4 | 6.2 | Cn1cc(-c2ccccc2)c(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | ||
| 24971237 | 194828 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 380 | 8 | 0 | 6 | 4.7 | CCC(CC)Oc1c(C)nc(-c2c(OC)cc(Cl)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | ||
| CHEMBL497653 | 194828 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 380 | 8 | 0 | 6 | 4.7 | CCC(CC)Oc1c(C)nc(-c2c(OC)cc(Cl)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | ||
| 57912459 | 89392 | 5 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 503 | 12 | 0 | 9 | 5.4 | CCCCN(c1c(OC)nn2c(-c3c(OC)cc(COCC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | ||
| CHEMBL2179195 | 89392 | 5 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 503 | 12 | 0 | 9 | 5.4 | CCCCN(c1c(OC)nn2c(-c3c(OC)cc(COCC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | ||
| 69658040 | 82982 | 0 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 419 | 6 | 0 | 5 | 5.4 | CC[C@@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(OC(F)F)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058335 | 82982 | 0 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 419 | 6 | 0 | 5 | 5.4 | CC[C@@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(OC(F)F)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 10249650 | 82972 | 0 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 387 | 4 | 0 | 4 | 5.4 | CC[C@@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058326 | 82972 | 0 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 387 | 4 | 0 | 4 | 5.4 | CC[C@@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 62706160 | 82853 | 0 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 418 | 6 | 0 | 7 | 3.6 | COCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(F)c(OC)cc3Cl)ncnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2057474 | 82853 | 0 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 418 | 6 | 0 | 7 | 3.6 | COCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(F)c(OC)cc3Cl)ncnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2370916 | 216730 | 0 | None | -13 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N(C)[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@@H](C)NC(=O)[C@H](CCC(N)=O)NC1=O)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm0202122 | ||||
| 70682293 | 83383 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 436 | 10 | 0 | 5 | 6.3 | CCCN(CCC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2063369 | 83383 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 436 | 10 | 0 | 5 | 6.3 | CCCN(CCC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 70682293 | 83383 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 436 | 10 | 0 | 5 | 6.3 | CCCN(CCC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| CHEMBL2063369 | 83383 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 436 | 10 | 0 | 5 | 6.3 | CCCN(CCC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| 58317340 | 133261 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 427 | 5 | 2 | 3 | 5.7 | O=C(N[C@H]1CC[C@H](CNc2cccc3ncccc23)CC1)c1cccc(C(F)(F)F)c1 | nan | ||
| CHEMBL3652062 | 133261 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 427 | 5 | 2 | 3 | 5.7 | O=C(N[C@H]1CC[C@H](CNc2cccc3ncccc23)CC1)c1cccc(C(F)(F)F)c1 | nan | ||
| 58317279 | 133315 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 394 | 4 | 1 | 4 | 4.5 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2nc(C)c(Cl)c2C)CC1 | nan | ||
| CHEMBL3652115 | 133315 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 394 | 4 | 1 | 4 | 4.5 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2nc(C)c(Cl)c2C)CC1 | nan | ||
| 9843598 | 74550 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 394 | 7 | 0 | 6 | 4.3 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(OC)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | ||
| CHEMBL190845 | 74550 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 394 | 7 | 0 | 6 | 4.3 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(OC)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | ||
| 58317422 | 133300 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 376 | 5 | 2 | 4 | 4.0 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CNc2ccc(F)cn2)CC1 | nan | ||
| CHEMBL3652100 | 133300 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 376 | 5 | 2 | 4 | 4.0 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](CNc2ccc(F)cn2)CC1 | nan | ||
| 9908904 | 187266 | 4 | None | -5 | 2 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm900025h | ||
| CHEMBL474287 | 187266 | 4 | None | -5 | 2 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm900025h | ||
| CHEMBL475306 | 187266 | 4 | None | -5 | 2 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm900025h | ||
| 10363079 | 82977 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 391 | 5 | 0 | 5 | 4.7 | CC[C@@H](COC)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058330 | 82977 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 391 | 5 | 0 | 5 | 4.7 | CC[C@@H](COC)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 71455052 | 88293 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 428 | 9 | 0 | 6 | 5.1 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(F)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2160168 | 88293 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 428 | 9 | 0 | 6 | 5.1 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(F)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 9865624 | 22316 | 12 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 398 | 9 | 0 | 7 | 3.9 | CCCN(CCOC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmc.2022.116614 | ||
| CHEMBL121896 | 22316 | 12 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 398 | 9 | 0 | 7 | 3.9 | CCCN(CCOC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmc.2022.116614 | ||
| 11774042 | 210131 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmc.2022.116614 | ||
| CHEMBL65078 | 210131 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmc.2022.116614 | ||
| 10338811 | 83067 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 364 | 5 | 0 | 6 | 3.8 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(OC)nc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058601 | 83067 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 364 | 5 | 0 | 6 | 3.8 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(OC)nc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 44815112 | 133251 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 411 | 5 | 2 | 3 | 5.2 | O=C(N[C@H]1CC[C@H](CNc2cccnc2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652052 | 133251 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 411 | 5 | 2 | 3 | 5.2 | O=C(N[C@H]1CC[C@H](CNc2cccnc2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 59186853 | 133297 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 429 | 5 | 2 | 4 | 5.4 | Cc1noc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1C | nan | ||
| CHEMBL3652097 | 133297 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 429 | 5 | 2 | 4 | 5.4 | Cc1noc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1C | nan | ||
| 59186802 | 133287 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 520 | 7 | 3 | 3 | 6.2 | CCCc1[nH]nc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1Br | nan | ||
| CHEMBL3652087 | 133287 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 520 | 7 | 3 | 3 | 6.2 | CCCc1[nH]nc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1Br | nan | ||
| 11025 | 9517 | 7 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 400 | 4 | 0 | 4 | 5.7 | CC[C@H]1Cn2nc(c3c2c(N1CC1CC1)cc(n3)C)c1ccc(cc1Cl)Cl | 10.1021/jm049085v | ||
| 11713007 | 9517 | 7 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 400 | 4 | 0 | 4 | 5.7 | CC[C@H]1Cn2nc(c3c2c(N1CC1CC1)cc(n3)C)c1ccc(cc1Cl)Cl | 10.1021/jm049085v | ||
| CHEMBL380800 | 9517 | 7 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 400 | 4 | 0 | 4 | 5.7 | CC[C@H]1Cn2nc(c3c2c(N1CC1CC1)cc(n3)C)c1ccc(cc1Cl)Cl | 10.1021/jm049085v | ||
| 10407938 | 82961 | 0 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 387 | 4 | 0 | 4 | 5.4 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058069 | 82961 | 0 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 387 | 4 | 0 | 4 | 5.4 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 70692690 | 82978 | 0 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 347 | 4 | 0 | 4 | 4.7 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3ccc(C)cc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058331 | 82978 | 0 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 347 | 4 | 0 | 4 | 4.7 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3ccc(C)cc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 58317325 | 133314 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 459 | 5 | 2 | 3 | 6.1 | Cc1ncc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)cc1Cl | nan | ||
| CHEMBL3652114 | 133314 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 459 | 5 | 2 | 3 | 6.1 | Cc1ncc(NC[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)cc1Cl | nan | ||
| 58317360 | 133274 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 455 | 6 | 2 | 4 | 5.5 | COc1ncc(C)cc1NC[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| CHEMBL3652075 | 133274 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 455 | 6 | 2 | 4 | 5.5 | COc1ncc(C)cc1NC[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | ||
| 53341022 | 142957 | 0 | None | 41 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 412 | 4 | 1 | 5 | 3.7 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2c(=O)n(C)c3ccccc32)CC1 | nan | ||
| CHEMBL3732721 | 142957 | 0 | None | 41 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 412 | 4 | 1 | 5 | 3.7 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2c(=O)n(C)c3ccccc32)CC1 | nan | ||
| 59186825 | 133276 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 464 | 5 | 3 | 3 | 5.9 | Cc1ccc2[nH]nc(NC[C@H]3CC[C@H](NC(=O)c4cc(C(F)(F)F)ccc4Cl)CC3)c2c1 | nan | ||
| CHEMBL3652077 | 133276 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 464 | 5 | 3 | 3 | 5.9 | Cc1ccc2[nH]nc(NC[C@H]3CC[C@H](NC(=O)c4cc(C(F)(F)F)ccc4Cl)CC3)c2c1 | nan | ||
| 70909805 | 146092 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 434 | 8 | 1 | 5 | 6.6 | CCCN(CCC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | ||
| CHEMBL3792517 | 146092 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 434 | 8 | 1 | 5 | 6.6 | CCCN(CCC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | ||
| 59186817 | 133275 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 451 | 5 | 3 | 4 | 5.0 | O=C(N[C@H]1CC[C@H](CNc2n[nH]c3ncccc23)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652076 | 133275 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 451 | 5 | 3 | 4 | 5.0 | O=C(N[C@H]1CC[C@H](CNc2n[nH]c3ncccc23)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 53341471 | 142363 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 494 | 4 | 1 | 2 | 5.9 | O=C(N[C@H]1CC[C@H](CN2C(=O)C3(CC3)c3cc(F)ccc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3729128 | 142363 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 494 | 4 | 1 | 2 | 5.9 | O=C(N[C@H]1CC[C@H](CN2C(=O)C3(CC3)c3cc(F)ccc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 10429933 | 83060 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 381 | 5 | 0 | 5 | 4.6 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3cc(F)c(OC)cc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058594 | 83060 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 381 | 5 | 0 | 5 | 4.6 | CC[C@H](C1CC1)n1c(=O)c(C)nc2c(-c3cc(F)c(OC)cc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 70692700 | 83058 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 433 | 6 | 0 | 5 | 5.7 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(Cl)c(OC(F)F)cc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058592 | 83058 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 433 | 6 | 0 | 5 | 5.7 | CCC(C1CC1)n1c(=O)c(C)nc2c(-c3cc(Cl)c(OC(F)F)cc3C)ccnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 21984718 | 84321 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 403 | 8 | 0 | 4 | 5.8 | CCc1nn2c(-c3c(C)cc(OC)cc3C)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | ||
| CHEMBL2087554 | 84321 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 403 | 8 | 0 | 4 | 5.8 | CCc1nn2c(-c3c(C)cc(OC)cc3C)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | ||
| 44816141 | 133254 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 469 | 5 | 2 | 4 | 4.1 | O=C(N[C@H]1CC[C@H](Cn2ccc(N3CCNC3=O)n2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652055 | 133254 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 469 | 5 | 2 | 4 | 4.1 | O=C(N[C@H]1CC[C@H](Cn2ccc(N3CCNC3=O)n2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 59186860 | 133277 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 468 | 5 | 3 | 3 | 5.8 | O=C(N[C@H]1CC[C@H](CNc2n[nH]c3ccc(F)cc23)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3652078 | 133277 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 468 | 5 | 3 | 3 | 5.8 | O=C(N[C@H]1CC[C@H](CNc2n[nH]c3ccc(F)cc23)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 53341470 | 142165 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 451 | 4 | 1 | 3 | 4.6 | O=C(N[C@H]1CC[C@H](CN2C(=O)Cc3cccnc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3727930 | 142165 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 451 | 4 | 1 | 3 | 4.6 | O=C(N[C@H]1CC[C@H](CN2C(=O)Cc3cccnc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 53341172 | 142962 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 451 | 4 | 2 | 3 | 5.0 | O=C(N[C@H]1CC[C@H](Cn2c(=O)[nH]c3ccccc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| CHEMBL3732765 | 142962 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 451 | 4 | 2 | 3 | 5.0 | O=C(N[C@H]1CC[C@H](Cn2c(=O)[nH]c3ccccc32)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | ||
| 71456850 | 88291 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 424 | 9 | 0 | 6 | 5.2 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2160166 | 88291 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 424 | 9 | 0 | 6 | 5.2 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 9822241 | 70783 | 8 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 399 | 8 | 1 | 6 | 5.0 | CCC(CC)Nc1nc(C)c(-c2ccc(OC(F)(F)F)cc2OC)nc1OC | 10.1021/jm200365y | ||
| CHEMBL1807053 | 70783 | 8 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 399 | 8 | 1 | 6 | 5.0 | CCC(CC)Nc1nc(C)c(-c2ccc(OC(F)(F)F)cc2OC)nc1OC | 10.1021/jm200365y | ||
| 70692845 | 83382 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 422 | 10 | 0 | 5 | 6.0 | CCCN(CCC)c1cccc2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| CHEMBL2063368 | 83382 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 422 | 10 | 0 | 5 | 6.0 | CCCN(CCC)c1cccc2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | ||
| 70692701 | 83071 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 392 | 5 | 0 | 6 | 4.1 | CC[C@H](COC)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ncnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| CHEMBL2058605 | 83071 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 392 | 5 | 0 | 6 | 4.1 | CC[C@H](COC)n1c(=O)c(C)nc2c(-c3ccc(Cl)cc3Cl)ncnc21 | 10.1016/j.bmcl.2012.06.034 | ||
| 59186874 | 133301 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 389 | 7 | 3 | 4 | 4.1 | CCCc1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)n[nH]1 | nan | ||
| CHEMBL3652101 | 133301 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 389 | 7 | 3 | 4 | 4.1 | CCCc1cc(NC[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)n[nH]1 | nan | ||
| 71462234 | 88297 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 452 | 11 | 0 | 6 | 6.0 | CCCN(CCC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| CHEMBL2160171 | 88297 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 452 | 11 | 0 | 6 | 6.0 | CCCN(CCC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | ||
| 11223423 | 196321 | 30 | None | - | 1 | Human | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 404 | 4 | 1 | 6 | 3.1 | COc1ccc(N2CCc3c(-n4ccc(N5CCNC5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | ||
| CHEMBL514270 | 196321 | 30 | None | - | 1 | Human | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 404 | 4 | 1 | 6 | 3.1 | COc1ccc(N2CCc3c(-n4ccc(N5CCNC5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | ||
| 11546255 | 194896 | 0 | None | - | 0 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 419 | 5 | 0 | 7 | 4.9 | CCC(CC)c1cc(C)nn2c(-c3sc(N4CCOCC4)nc3Cl)c(C)nc12 | 10.1021/jm200365y | ||
| CHEMBL498311 | 194896 | 0 | None | - | 0 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 419 | 5 | 0 | 7 | 4.9 | CCC(CC)c1cc(C)nn2c(-c3sc(N4CCOCC4)nc3Cl)c(C)nc12 | 10.1021/jm200365y | ||
| 54591779 | 72804 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 429 | 8 | 1 | 7 | 4.6 | COc1cc(OC(F)F)ccc1-n1c(C)nc2c(NC(C3CC3)C3CC3)nc(C)nc21 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836947 | 72804 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 429 | 8 | 1 | 7 | 4.6 | COc1cc(OC(F)F)ccc1-n1c(C)nc2c(NC(C3CC3)C3CC3)nc(C)nc21 | 10.1016/j.bmcl.2011.08.040 | ||
| 44545165 | 72802 | 0 | None | - | 0 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 433 | 7 | 1 | 6 | 5.3 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(OC(F)F)cc3Cl)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836945 | 72802 | 0 | None | - | 0 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 433 | 7 | 1 | 6 | 5.3 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(OC(F)F)cc3Cl)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| 9821586 | 174882 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1021/jm200365y | ||
| CHEMBL432800 | 174882 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1021/jm200365y | ||
| 9884878 | 179804 | 18 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 352 | 6 | 1 | 5 | 4.9 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL45187 | 179804 | 18 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 352 | 6 | 1 | 5 | 4.9 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1016/j.bmcl.2011.08.040 | ||
| 11509708 | 25764 | 3 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | CC[C@@H](Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12)c1nc(C)no1 | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1287905 | 25764 | 3 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | CC[C@@H](Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12)c1nc(C)no1 | 10.1016/j.bmcl.2010.10.095 | ||
| 11509709 | 25774 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | CCC(Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12)c1nnc(C)o1 | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1287996 | 25774 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | CCC(Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12)c1nnc(C)o1 | 10.1016/j.bmcl.2010.10.095 | ||
| 45485065 | 203809 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 378 | 7 | 0 | 7 | 3.5 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(C#N)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL567164 | 203809 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 378 | 7 | 0 | 7 | 3.5 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(C#N)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 56663539 | 70713 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCN(CCC)c1c(C)ncc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1021/jm200365y | ||
| CHEMBL1806727 | 70713 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCN(CCC)c1c(C)ncc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1021/jm200365y | ||
| 9980466 | 160907 | 0 | None | - | 0 | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 436 | 9 | 1 | 6 | 5.2 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OCCF | 10.1021/jm200365y | ||
| CHEMBL398531 | 160907 | 0 | None | - | 0 | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 436 | 9 | 1 | 6 | 5.2 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OCCF | 10.1021/jm200365y | ||
| 10255153 | 84334 | 8 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 493 | 11 | 0 | 7 | 5.4 | CCc1nn2c(-c3c(OC)cc(COC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | ||
| CHEMBL2087549 | 84334 | 8 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 493 | 11 | 0 | 7 | 5.4 | CCc1nn2c(-c3c(OC)cc(COC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | ||
| CHEMBL2087567 | 84334 | 8 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 493 | 11 | 0 | 7 | 5.4 | CCc1nn2c(-c3c(OC)cc(COC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | ||
| 56835113 | 76392 | 0 | None | - | 0 | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 408 | 8 | 0 | 5 | 5.7 | CCCCN(CC)c1nc(C)nc2c1c(C)c(COC)n2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2011.10.066 | ||
| CHEMBL1934751 | 76392 | 0 | None | - | 0 | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 408 | 8 | 0 | 5 | 5.7 | CCCCN(CC)c1nc(C)nc2c1c(C)c(COC)n2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2011.10.066 | ||
| 56672697 | 72797 | 0 | None | - | 0 | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 367 | 5 | 1 | 5 | 4.7 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(Cl)cc3)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836940 | 72797 | 0 | None | - | 0 | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 367 | 5 | 1 | 5 | 4.7 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(Cl)cc3)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| 45485057 | 203787 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 355 | 6 | 2 | 7 | 2.9 | CC[C@H](CO)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL566939 | 203787 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 355 | 6 | 2 | 7 | 2.9 | CC[C@H](CO)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 45485022 | 203844 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 369 | 7 | 0 | 7 | 3.2 | CCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL567383 | 203844 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 369 | 7 | 0 | 7 | 3.2 | CCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 44446725 | 175732 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 376 | 7 | 0 | 3 | 6.5 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | ||
| CHEMBL438888 | 175732 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 376 | 7 | 0 | 3 | 6.5 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | ||
| 3496 | 7963 | 42 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | ||
| 9862166 | 7963 | 42 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | ||
| CHEMBL270948 | 7963 | 42 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | ||
| 3496 | 7963 | 42 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | ||
| 9862166 | 7963 | 42 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | ||
| CHEMBL270948 | 7963 | 42 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | ||
| 3520 | 10041 | 54 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2011.08.040 | ||
| 9821250 | 10041 | 54 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL309138 | 10041 | 54 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2011.08.040 | ||
| 44545284 | 72803 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 397 | 6 | 1 | 6 | 4.7 | COc1ccc(-n2c(C)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)c(Cl)c1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836946 | 72803 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 397 | 6 | 1 | 6 | 4.7 | COc1ccc(-n2c(C)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)c(Cl)c1 | 10.1016/j.bmcl.2011.08.040 | ||
| 45485056 | 203786 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 422 | 8 | 2 | 10 | 3.4 | CCCNCc1nc(Nc2nc(C)nc3c2c(C)nn3-c2ccc(OC)cc2C)no1 | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL566938 | 203786 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 422 | 8 | 2 | 10 | 3.4 | CCCNCc1nc(Nc2nc(C)nc3c2c(C)nn3-c2ccc(OC)cc2C)no1 | 10.1016/j.bmcl.2009.09.016 | ||
| 45485032 | 203781 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 369 | 7 | 1 | 7 | 3.0 | CCCN(CCO)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL566910 | 203781 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 369 | 7 | 1 | 7 | 3.0 | CCCN(CCO)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 45485040 | 204063 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 383 | 8 | 0 | 7 | 3.6 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL568606 | 204063 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 383 | 8 | 0 | 7 | 3.6 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 45485040 | 204063 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 383 | 8 | 0 | 7 | 3.6 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL568606 | 204063 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 383 | 8 | 0 | 7 | 3.6 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2011.08.040 | ||
| 45484977 | 204069 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 383 | 9 | 1 | 7 | 4.1 | CCCC(CCOC)Nc1nc(C)nc2c1cnn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL568656 | 204069 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 383 | 9 | 1 | 7 | 4.1 | CCCC(CCOC)Nc1nc(C)nc2c1cnn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 45485009 | 205215 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 369 | 7 | 1 | 7 | 3.6 | CC[C@@H](COC)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL577239 | 205215 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 369 | 7 | 1 | 7 | 3.6 | CC[C@@H](COC)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 44543774 | 72790 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 377 | 6 | 1 | 6 | 4.4 | COc1ccc(-n2c(C)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)c(C)c1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836933 | 72790 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 377 | 6 | 1 | 6 | 4.4 | COc1ccc(-n2c(C)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)c(C)c1 | 10.1016/j.bmcl.2011.08.040 | ||
| 56658150 | 72391 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 411 | 6 | 1 | 7 | 3.4 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(S(C)(=O)=O)cc3)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1834003 | 72391 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 411 | 6 | 1 | 7 | 3.4 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(S(C)(=O)=O)cc3)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| 45485033 | 203782 | 0 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 410 | 7 | 0 | 7 | 3.1 | CCCN(CC(=O)N(C)C)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL566911 | 203782 | 0 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 410 | 7 | 0 | 7 | 3.1 | CCCN(CC(=O)N(C)C)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 56682683 | 72791 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 393 | 8 | 1 | 7 | 3.9 | COCc1nc2c(NC(C3CC3)C3CC3)nc(C)nc2n1-c1ccc(OC)cc1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836934 | 72791 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 393 | 8 | 1 | 7 | 3.9 | COCc1nc2c(NC(C3CC3)C3CC3)nc(C)nc2n1-c1ccc(OC)cc1 | 10.1016/j.bmcl.2011.08.040 | ||
| 18691322 | 11433 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 397 | 2 | 0 | 5 | 5.1 | Cc1cc(C)c(-n2nnc3c(-c4ccccc4C(F)(F)F)nc(C)nc32)c(C)c1 | 10.1016/s0960-894x(99)00133-x | ||
| CHEMBL10315 | 11433 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 397 | 2 | 0 | 5 | 5.1 | Cc1cc(C)c(-n2nnc3c(-c4ccccc4C(F)(F)F)nc(C)nc32)c(C)c1 | 10.1016/s0960-894x(99)00133-x | ||
| 45484988 | 204080 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 400 | 9 | 0 | 9 | 2.7 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)nc1OC | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL568685 | 204080 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 400 | 9 | 0 | 9 | 2.7 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)nc1OC | 10.1016/j.bmcl.2009.09.016 | ||
| 45484992 | 205681 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 397 | 8 | 0 | 8 | 3.1 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1cnc(N(C)C)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL584472 | 205681 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 397 | 8 | 0 | 8 | 3.1 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1cnc(N(C)C)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 54591854 | 72789 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 363 | 6 | 1 | 6 | 4.0 | COc1ccc(-n2c(C)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)cc1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836932 | 72789 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 363 | 6 | 1 | 6 | 4.0 | COc1ccc(-n2c(C)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)cc1 | 10.1016/j.bmcl.2011.08.040 | ||
| 45485023 | 205531 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL583005 | 205531 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 3533 | 7989 | 24 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 482 | 8 | 0 | 4 | 7.5 | C#CCN([C@H](c1ccc(c(c1)F)C)CC1CC1)c1sc(c(n1)c1cc(C)c(cc1Cl)OC)C | 10.1021/jm200365y | ||
| 5282340 | 7989 | 24 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 482 | 8 | 0 | 4 | 7.5 | C#CCN([C@H](c1ccc(c(c1)F)C)CC1CC1)c1sc(c(n1)c1cc(C)c(cc1Cl)OC)C | 10.1021/jm200365y | ||
| CHEMBL291657 | 7989 | 24 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 482 | 8 | 0 | 4 | 7.5 | C#CCN([C@H](c1ccc(c(c1)F)C)CC1CC1)c1sc(c(n1)c1cc(C)c(cc1Cl)OC)C | 10.1021/jm200365y | ||
| 3499 | 8230 | 28 | None | -25 | 2 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm200365y | ||
| 9909468 | 8230 | 28 | None | -25 | 2 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm200365y | ||
| CHEMBL44698 | 8230 | 28 | None | -25 | 2 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm200365y | ||
| 176157 | 9515 | 28 | None | - | 2 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1021/jm200365y | ||
| 3512 | 9515 | 28 | None | - | 2 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1021/jm200365y | ||
| CHEMBL45281 | 9515 | 28 | None | - | 2 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1021/jm200365y | ||
| 44266581 | 11199 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 398 | 6 | 1 | 4 | 6.0 | CCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C | 10.1016/s0960-894x(99)00133-x | ||
| CHEMBL10154 | 11199 | 0 | None | - | 0 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 398 | 6 | 1 | 4 | 6.0 | CCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C | 10.1016/s0960-894x(99)00133-x | ||
| 3495 | 7958 | 28 | None | -14 | 2 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/s0960-894x(99)00133-x | ||
| 5311055 | 7958 | 28 | None | -14 | 2 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/s0960-894x(99)00133-x | ||
| CHEMBL9946 | 7958 | 28 | None | -14 | 2 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/s0960-894x(99)00133-x | ||
| 56662343 | 72799 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 377 | 7 | 1 | 6 | 4.4 | CCOc1ccc(-n2c(C)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)cc1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836942 | 72799 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 377 | 7 | 1 | 6 | 4.4 | CCOc1ccc(-n2c(C)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)cc1 | 10.1016/j.bmcl.2011.08.040 | ||
| 18691310 | 11379 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 508 | 4 | 1 | 7 | 5.3 | COc1cc(Br)c(-n2c(O)nc3c(-c4ccccc4C(F)(F)F)nc(C)nc32)c(OC)c1 | 10.1016/s0960-894x(99)00133-x | ||
| CHEMBL10279 | 11379 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 508 | 4 | 1 | 7 | 5.3 | COc1cc(Br)c(-n2c(O)nc3c(-c4ccccc4C(F)(F)F)nc(C)nc32)c(OC)c1 | 10.1016/s0960-894x(99)00133-x | ||
| 44266488 | 105300 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 493 | 4 | 0 | 7 | 5.0 | COc1cc(Br)c(-n2nnc3c(-c4ccccc4C(F)(F)F)nc(C)nc32)c(OC)c1 | 10.1016/s0960-894x(99)00133-x | ||
| CHEMBL276263 | 105300 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 493 | 4 | 0 | 7 | 5.0 | COc1cc(Br)c(-n2nnc3c(-c4ccccc4C(F)(F)F)nc(C)nc32)c(OC)c1 | 10.1016/s0960-894x(99)00133-x | ||
| 45485034 | 203783 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 369 | 7 | 1 | 7 | 3.6 | CC[C@H](COC)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL566912 | 203783 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 369 | 7 | 1 | 7 | 3.6 | CC[C@H](COC)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 44446726 | 101609 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 476 | 11 | 0 | 3 | 7.5 | CCCN(CCC)c1c(C)nc(-c2c(CC(F)F)cc(CC(F)F)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | ||
| CHEMBL253699 | 101609 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 476 | 11 | 0 | 3 | 7.5 | CCCN(CCC)c1c(C)nc(-c2c(CC(F)F)cc(CC(F)F)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | ||
| 18691303 | 11073 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 512 | 6 | 1 | 7 | 5.9 | COc1cc(Br)c(Nc2nc(C)nc(-c3ccccc3C(F)(F)F)c2[N+](=O)[O-])c(OC)c1 | 10.1016/s0960-894x(99)00133-x | ||
| CHEMBL10080 | 11073 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 512 | 6 | 1 | 7 | 5.9 | COc1cc(Br)c(Nc2nc(C)nc(-c3ccccc3C(F)(F)F)c2[N+](=O)[O-])c(OC)c1 | 10.1016/s0960-894x(99)00133-x | ||
| 52947302 | 25760 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 392 | 5 | 1 | 8 | 4.2 | COc1ccc(-c2c(C)nn3c(NC(C)c4nc(C)no4)cc(C)nc23)c(C)c1 | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1287878 | 25760 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 392 | 5 | 1 | 8 | 4.2 | COc1ccc(-c2c(C)nn3c(NC(C)c4nc(C)no4)cc(C)nc23)c(C)c1 | 10.1016/j.bmcl.2010.10.095 | ||
| 45484976 | 203843 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 420 | 8 | 2 | 9 | 3.3 | CCCNCc1cncn1Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL567382 | 203843 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 420 | 8 | 2 | 9 | 3.3 | CCCNCc1cncn1Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 11697131 | 25775 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.1 | COc1ccc(-c2c(C)nn3c(NC(C)Cc4nnc(C)o4)cc(C)nc23)c(C)c1 | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1287997 | 25775 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.1 | COc1ccc(-c2c(C)nn3c(NC(C)Cc4nnc(C)o4)cc(C)nc23)c(C)c1 | 10.1016/j.bmcl.2010.10.095 | ||
| 56682684 | 72795 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 439 | 7 | 1 | 6 | 5.2 | COc1ccc(-n2c(C3CC(F)(F)C3)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)cc1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836938 | 72795 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 439 | 7 | 1 | 6 | 5.2 | COc1ccc(-n2c(C3CC(F)(F)C3)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)cc1 | 10.1016/j.bmcl.2011.08.040 | ||
| 45485079 | 203870 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 396 | 8 | 1 | 7 | 2.7 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(C(N)=O)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL567538 | 203870 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 396 | 8 | 1 | 7 | 2.7 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(C(N)=O)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 3495 | 7958 | 28 | None | -14 | 2 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm200365y | ||
| 5311055 | 7958 | 28 | None | -14 | 2 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm200365y | ||
| CHEMBL9946 | 7958 | 28 | None | -14 | 2 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm200365y | ||
| 3520 | 10041 | 54 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm200365y | ||
| 9821250 | 10041 | 54 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm200365y | ||
| CHEMBL309138 | 10041 | 54 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm200365y | ||
| 9955329 | 214609 | 0 | None | - | 0 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 448 | 8 | 0 | 8 | 3.9 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1c(Br)cc(OC)cc1OC | 10.1016/s0960-894x(99)00133-x | ||
| CHEMBL9633 | 214609 | 0 | None | - | 0 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 448 | 8 | 0 | 8 | 3.9 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1c(Br)cc(OC)cc1OC | 10.1016/s0960-894x(99)00133-x | ||
| 9934089 | 11779 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 462 | 9 | 0 | 8 | 3.5 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00133-x | ||
| CHEMBL10504 | 11779 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 462 | 9 | 0 | 8 | 3.5 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00133-x | ||
| 3520 | 10041 | 54 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2010.10.095 | ||
| 9821250 | 10041 | 54 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL309138 | 10041 | 54 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2010.10.095 | ||
| 56658860 | 72792 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 403 | 8 | 1 | 6 | 4.7 | COc1ccc(-n2c(CC3CC3)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)cc1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836935 | 72792 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 403 | 8 | 1 | 6 | 4.7 | COc1ccc(-n2c(CC3CC3)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)cc1 | 10.1016/j.bmcl.2011.08.040 | ||
| 11509641 | 25765 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 404 | 5 | 1 | 8 | 4.1 | COc1ccc(-c2c(C)nn3c(NC4(c5nc(C)no5)CC4)cc(C)nc23)c(C)c1 | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1287936 | 25765 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 404 | 5 | 1 | 8 | 4.1 | COc1ccc(-c2c(C)nn3c(NC4(c5nc(C)no5)CC4)cc(C)nc23)c(C)c1 | 10.1016/j.bmcl.2010.10.095 | ||
| 11531570 | 25771 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.1 | COc1ccc(-c2c(C)nn3c(NC(C)Cc4nc(C)no4)cc(C)nc23)c(C)c1 | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1287966 | 25771 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.1 | COc1ccc(-c2c(C)nn3c(NC(C)Cc4nc(C)no4)cc(C)nc23)c(C)c1 | 10.1016/j.bmcl.2010.10.095 | ||
| 45485105 | 204207 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 367 | 8 | 1 | 6 | 4.8 | CCCC(CCC)Nc1nc(C)nc2c1cnn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL569666 | 204207 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 367 | 8 | 1 | 6 | 4.8 | CCCC(CCC)Nc1nc(C)nc2c1cnn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 177990 | 7214 | 23 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1016/j.bmcl.2011.10.066 | ||
| 3489 | 7214 | 23 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1016/j.bmcl.2011.10.066 | ||
| CHEMBL296641 | 7214 | 23 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1016/j.bmcl.2011.10.066 | ||
| 46175148 | 72806 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 363 | 6 | 1 | 6 | 4.0 | COc1ccc(-n2ncc3c(NC(C4CC4)C4CC4)nc(C)nc32)c(C)c1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836950 | 72806 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 363 | 6 | 1 | 6 | 4.0 | COc1ccc(-n2ncc3c(NC(C4CC4)C4CC4)nc(C)nc32)c(C)c1 | 10.1016/j.bmcl.2011.08.040 | ||
| 18691329 | 11175 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 506 | 4 | 0 | 6 | 5.9 | COc1cc(Br)c(-n2c(C)nc3c(-c4ccccc4C(F)(F)F)nc(C)nc32)c(OC)c1 | 10.1016/s0960-894x(99)00133-x | ||
| CHEMBL10142 | 11175 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 506 | 4 | 0 | 6 | 5.9 | COc1cc(Br)c(-n2c(C)nc3c(-c4ccccc4C(F)(F)F)nc(C)nc32)c(OC)c1 | 10.1016/s0960-894x(99)00133-x | ||
| 44266555 | 11232 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 502 | 3 | 0 | 5 | 7.5 | CSc1nn(-c2c(Cl)cc(Cl)cc2Cl)c2nc(C)nc(-c3ccccc3C(F)(F)F)c12 | 10.1016/s0960-894x(99)00133-x | ||
| CHEMBL10174 | 11232 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 502 | 3 | 0 | 5 | 7.5 | CSc1nn(-c2c(Cl)cc(Cl)cc2Cl)c2nc(C)nc(-c3ccccc3C(F)(F)F)c12 | 10.1016/s0960-894x(99)00133-x | ||
| 45485086 | 203703 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 381 | 8 | 1 | 6 | 5.1 | CCCC(CCC)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL566279 | 203703 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 381 | 8 | 1 | 6 | 5.1 | CCCC(CCC)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 10375 | 9516 | 18 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 416 | 6 | 0 | 4 | 6.5 | CCCC(N1CCn2c3c1cc(C)nc3c(n2)c1ccc(cc1Cl)Cl)CCC | 10.1021/jm200365y | ||
| 9888194 | 9516 | 18 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 416 | 6 | 0 | 4 | 6.5 | CCCC(N1CCn2c3c1cc(C)nc3c(n2)c1ccc(cc1Cl)Cl)CCC | 10.1021/jm200365y | ||
| CHEMBL188907 | 9516 | 18 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 416 | 6 | 0 | 4 | 6.5 | CCCC(N1CCn2c3c1cc(C)nc3c(n2)c1ccc(cc1Cl)Cl)CCC | 10.1021/jm200365y | ||
| 45485080 | 203903 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 420 | 8 | 2 | 9 | 3.3 | CCCNCc1nccn1Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL567741 | 203903 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 420 | 8 | 2 | 9 | 3.3 | CCCNCc1nccn1Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 45485073 | 203556 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 353 | 6 | 1 | 6 | 4.4 | CCC(CC)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL565442 | 203556 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 353 | 6 | 1 | 6 | 4.4 | CCC(CC)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 45484980 | 204072 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 384 | 8 | 0 | 8 | 3.0 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)nc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL568665 | 204072 | 0 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 384 | 8 | 0 | 8 | 3.0 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)nc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 56676057 | 72788 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 363 | 6 | 1 | 6 | 4.0 | COc1ccc(-n2cnc3c(NC(C4CC4)C4CC4)nc(C)nc32)c(C)c1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836931 | 72788 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 363 | 6 | 1 | 6 | 4.0 | COc1ccc(-n2cnc3c(NC(C4CC4)C4CC4)nc(C)nc32)c(C)c1 | 10.1016/j.bmcl.2011.08.040 | ||
| 44545161 | 72801 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 399 | 7 | 1 | 6 | 4.6 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(OC(F)F)cc3)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836944 | 72801 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 399 | 7 | 1 | 6 | 4.6 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(OC(F)F)cc3)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| 11589539 | 25759 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 406 | 6 | 0 | 8 | 4.0 | CCN(Cc1nc(C)no1)c1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1287877 | 25759 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 406 | 6 | 0 | 8 | 4.0 | CCN(Cc1nc(C)no1)c1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1016/j.bmcl.2010.10.095 | ||
| 10367821 | 11077 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 478 | 5 | 0 | 4 | 6.9 | CCN(c1nc(C)nc(-c2ccccc2C(F)(F)F)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00133-x | ||
| CHEMBL10082 | 11077 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 478 | 5 | 0 | 4 | 6.9 | CCN(c1nc(C)nc(-c2ccccc2C(F)(F)F)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00133-x | ||
| 52944875 | 25770 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 418 | 5 | 1 | 8 | 4.5 | COc1ccc(-c2c(C)nn3c(NC4(c5nc(C)no5)CCC4)cc(C)nc23)c(C)c1 | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1287965 | 25770 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 418 | 5 | 1 | 8 | 4.5 | COc1ccc(-c2c(C)nn3c(NC4(c5nc(C)no5)CCC4)cc(C)nc23)c(C)c1 | 10.1016/j.bmcl.2010.10.095 | ||
| 52947334 | 25779 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 420 | 6 | 1 | 9 | 4.0 | CCC(Nc1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12)c1nc(C)no1 | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1288027 | 25779 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 420 | 6 | 1 | 9 | 4.0 | CCC(Nc1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12)c1nc(C)no1 | 10.1016/j.bmcl.2010.10.095 | ||
| 11531898 | 25784 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 422 | 7 | 1 | 9 | 4.3 | CCC(Nc1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12)c1nc(C)no1 | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1288058 | 25784 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 422 | 7 | 1 | 9 | 4.3 | CCC(Nc1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12)c1nc(C)no1 | 10.1016/j.bmcl.2010.10.095 | ||
| 57390674 | 76391 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 392 | 7 | 0 | 5 | 5.4 | CCCCN(CC)c1nc(C)nc2c1c(C)c(C=O)n2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2011.10.066 | ||
| CHEMBL1934750 | 76391 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 392 | 7 | 0 | 5 | 5.4 | CCCCN(CC)c1nc(C)nc2c1c(C)c(C=O)n2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2011.10.066 | ||
| 45485042 | 204146 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 369 | 7 | 2 | 7 | 3.3 | CCC[C@@H](CO)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL569202 | 204146 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 369 | 7 | 2 | 7 | 3.3 | CCC[C@@H](CO)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 45485008 | 205149 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 397 | 8 | 1 | 8 | 2.1 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(C(N)=O)nc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL576639 | 205149 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 397 | 8 | 1 | 8 | 2.1 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(C(N)=O)nc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 56835112 | 76390 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 394 | 7 | 1 | 5 | 5.1 | CCCCN(CC)c1nc(C)nc2c1c(C)c(CO)n2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2011.10.066 | ||
| CHEMBL1934749 | 76390 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 394 | 7 | 1 | 5 | 5.1 | CCCCN(CC)c1nc(C)nc2c1c(C)c(CO)n2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2011.10.066 | ||
| 10378 | 10757 | 37 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | COc1ccc(c(c1)C)c1c(C)nn2c1nc(C)cc2N[C@H](c1onc(n1)C)CC | 10.1016/j.bmcl.2010.10.095 | ||
| 11596613 | 10757 | 37 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | COc1ccc(c(c1)C)c1c(C)nn2c1nc(C)cc2N[C@H](c1onc(n1)C)CC | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1287935 | 10757 | 37 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | COc1ccc(c(c1)C)c1c(C)nn2c1nc(C)cc2N[C@H](c1onc(n1)C)CC | 10.1016/j.bmcl.2010.10.095 | ||
| DB12512 | 10757 | 37 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | COc1ccc(c(c1)C)c1c(C)nn2c1nc(C)cc2N[C@H](c1onc(n1)C)CC | 10.1016/j.bmcl.2010.10.095 | ||
| 18691308 | 11098 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 482 | 5 | 2 | 6 | 5.6 | COc1cc(Br)c(Nc2nc(C)nc(-c3ccccc3C(F)(F)F)c2N)c(OC)c1 | 10.1016/s0960-894x(99)00133-x | ||
| CHEMBL10091 | 11098 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 482 | 5 | 2 | 6 | 5.6 | COc1cc(Br)c(Nc2nc(C)nc(-c3ccccc3C(F)(F)F)c2N)c(OC)c1 | 10.1016/s0960-894x(99)00133-x | ||
| 56672696 | 72793 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 405 | 8 | 1 | 6 | 4.9 | COc1ccc(-n2c(CC(C)C)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)cc1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836936 | 72793 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 405 | 8 | 1 | 6 | 4.9 | COc1ccc(-n2c(CC(C)C)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)cc1 | 10.1016/j.bmcl.2011.08.040 | ||
| 56682685 | 72796 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 358 | 5 | 1 | 6 | 3.9 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(C#N)cc3)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836939 | 72796 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 358 | 5 | 1 | 6 | 3.9 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(C#N)cc3)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| 45485045 | 204028 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 355 | 6 | 2 | 7 | 2.9 | CC[C@@H](CO)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL568397 | 204028 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 355 | 6 | 2 | 7 | 2.9 | CC[C@@H](CO)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 11538121 | 25756 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 378 | 5 | 1 | 8 | 3.6 | COc1ccc(-c2c(C)nn3c(NCc4nc(C)no4)cc(C)nc23)c(C)c1 | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1287848 | 25756 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 378 | 5 | 1 | 8 | 3.6 | COc1ccc(-c2c(C)nn3c(NCc4nc(C)no4)cc(C)nc23)c(C)c1 | 10.1016/j.bmcl.2010.10.095 | ||
| 45485078 | 205561 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 389 | 7 | 0 | 8 | 3.0 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(C#N)cc1C#N | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL583223 | 205561 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 389 | 7 | 0 | 8 | 3.0 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(C#N)cc1C#N | 10.1016/j.bmcl.2009.09.016 | ||
| 44545396 | 72805 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 417 | 7 | 1 | 6 | 4.8 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(OC(F)F)cc3F)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836948 | 72805 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 417 | 7 | 1 | 6 | 4.8 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(OC(F)F)cc3F)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| 10377 | 7962 | 27 | None | 3 | 2 | Rat | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070578k | ||
| 9818802 | 7962 | 27 | None | 3 | 2 | Rat | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070578k | ||
| CHEMBL270738 | 7962 | 27 | None | 3 | 2 | Rat | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070578k | ||
| 11545949 | 25763 | 10 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | CCC(Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12)c1nc(C)no1 | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1287904 | 25763 | 10 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.6 | CCC(Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12)c1nc(C)no1 | 10.1016/j.bmcl.2010.10.095 | ||
| 45485064 | 205564 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 399 | 9 | 0 | 8 | 3.3 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1OC | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL583237 | 205564 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 399 | 9 | 0 | 8 | 3.3 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1OC | 10.1016/j.bmcl.2009.09.016 | ||
| 45485035 | 203665 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 369 | 7 | 2 | 7 | 3.3 | CCC[C@H](CO)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL566073 | 203665 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 369 | 7 | 2 | 7 | 3.3 | CCC[C@H](CO)Nc1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 52947738 | 25778 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.1 | COc1ccc(-c2c(C)nn3c(NC(C)Cc4noc(C)n4)cc(C)nc23)c(C)c1 | 10.1016/j.bmcl.2010.10.095 | ||
| CHEMBL1288026 | 25778 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 406 | 6 | 1 | 8 | 4.1 | COc1ccc(-c2c(C)nn3c(NC(C)Cc4noc(C)n4)cc(C)nc23)c(C)c1 | 10.1016/j.bmcl.2010.10.095 | ||
| 3520 | 10041 | 54 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm300259r | ||
| 9821250 | 10041 | 54 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm300259r | ||
| CHEMBL309138 | 10041 | 54 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm300259r | ||
| 10377 | 7962 | 27 | None | -3 | 2 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070578k | ||
| 9818802 | 7962 | 27 | None | -3 | 2 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070578k | ||
| CHEMBL270738 | 7962 | 27 | None | -3 | 2 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070578k | ||
| 45485050 | 203985 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 422 | 8 | 2 | 10 | 3.4 | CCCNCc1noc(Nc2nc(C)nc3c2c(C)nn3-c2ccc(OC)cc2C)n1 | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL568188 | 203985 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 422 | 8 | 2 | 10 | 3.4 | CCCNCc1noc(Nc2nc(C)nc3c2c(C)nn3-c2ccc(OC)cc2C)n1 | 10.1016/j.bmcl.2009.09.016 | ||
| 45484981 | 205152 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 339 | 6 | 1 | 6 | 4.0 | CCC(CC)Nc1nc(C)nc2c1cnn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL576664 | 205152 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 339 | 6 | 1 | 6 | 4.0 | CCC(CC)Nc1nc(C)nc2c1cnn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 56662342 | 72794 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 419 | 7 | 1 | 7 | 4.6 | COc1ccc(-n2c(C3CCCO3)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)cc1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836937 | 72794 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 419 | 7 | 1 | 7 | 4.6 | COc1ccc(-n2c(C3CCCO3)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)cc1 | 10.1016/j.bmcl.2011.08.040 | ||
| 24971237 | 194828 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 380 | 8 | 0 | 6 | 4.7 | CCC(CC)Oc1c(C)nc(-c2c(OC)cc(Cl)cc2OC)nc1OC | 10.1021/jm200365y | ||
| CHEMBL497653 | 194828 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 380 | 8 | 0 | 6 | 4.7 | CCC(CC)Oc1c(C)nc(-c2c(OC)cc(Cl)cc2OC)nc1OC | 10.1021/jm200365y | ||
| 22004628 | 205085 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 365 | 6 | 0 | 5 | 5.0 | CCCCN(CC)c1nc(C)nc2c1c(C)nn2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL576049 | 205085 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 365 | 6 | 0 | 5 | 5.0 | CCCCN(CC)c1nc(C)nc2c1c(C)nn2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2009.09.016 | ||
| 56672698 | 72800 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 417 | 6 | 1 | 6 | 4.9 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(OC(F)(F)F)cc3)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836943 | 72800 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 417 | 6 | 1 | 6 | 4.9 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(OC(F)(F)F)cc3)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| 18691298 | 104935 | 0 | None | - | 0 | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 423 | 2 | 0 | 3 | 7.0 | Cc1cc(C)c(-n2c(C)c(C)c3c(-c4ccccc4C(F)(F)F)nc(C)nc32)c(C)c1 | 10.1016/s0960-894x(99)00133-x | ||
| CHEMBL273839 | 104935 | 0 | None | - | 0 | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 423 | 2 | 0 | 3 | 7.0 | Cc1cc(C)c(-n2c(C)c(C)c3c(-c4ccccc4C(F)(F)F)nc(C)nc32)c(C)c1 | 10.1016/s0960-894x(99)00133-x | ||
| 44545281 | 72798 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 351 | 5 | 1 | 5 | 4.2 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(F)cc3)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| CHEMBL1836941 | 72798 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 351 | 5 | 1 | 5 | 4.2 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(F)cc3)c2n1 | 10.1016/j.bmcl.2011.08.040 | ||
| 18691301 | 11096 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 522 | 4 | 0 | 7 | 4.9 | COc1cc(Br)c(-n2c(=O)n(C)c3c(-c4ccccc4C(F)(F)F)nc(C)nc32)c(OC)c1 | 10.1016/s0960-894x(99)00133-x | ||
| CHEMBL10090 | 11096 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 522 | 4 | 0 | 7 | 4.9 | COc1cc(Br)c(-n2c(=O)n(C)c3c(-c4ccccc4C(F)(F)F)nc(C)nc32)c(OC)c1 | 10.1016/s0960-894x(99)00133-x | ||
| 45485041 | 204064 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 422 | 8 | 2 | 10 | 3.4 | CCCNCc1nnc(Nc2nc(C)nc3c2c(C)nn3-c2ccc(OC)cc2C)o1 | 10.1016/j.bmcl.2009.09.016 | ||
| CHEMBL568607 | 204064 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 422 | 8 | 2 | 10 | 3.4 | CCCNCc1nnc(Nc2nc(C)nc3c2c(C)nn3-c2ccc(OC)cc2C)o1 | 10.1016/j.bmcl.2009.09.016 | ||
| 10379 | 9833 | 39 | None | -1 | 3 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | Guide to Pharmacology | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 28174066 | ||
| 9884366 | 9833 | 39 | None | -1 | 3 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | Guide to Pharmacology | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 28174066 | ||
| CHEMBL482950 | 9833 | 39 | None | -1 | 3 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | Guide to Pharmacology | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 28174066 | ||
| DB12572 | 9833 | 39 | None | -1 | 3 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | Guide to Pharmacology | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 28174066 | ||
| 3498 | 7987 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | Guide to Pharmacology | 476 | 7 | 0 | 5 | 7.2 | CCN(c1ccc(cc1SC)C(C)C)c1nc(cc(n1)C)N1CCC(=CC1)c1cccc(c1)F | 10357258 | ||
| 9849313 | 7987 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | Guide to Pharmacology | 476 | 7 | 0 | 5 | 7.2 | CCN(c1ccc(cc1SC)C(C)C)c1nc(cc(n1)C)N1CCC(=CC1)c1cccc(c1)F | 10357258 | ||
| CHEMBL297986 | 7987 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | Guide to Pharmacology | 476 | 7 | 0 | 5 | 7.2 | CCN(c1ccc(cc1SC)C(C)C)c1nc(cc(n1)C)N1CCC(=CC1)c1cccc(c1)F | 10357258 | ||
| 3496 | 7963 | 42 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 18288792 | ||
| 9862166 | 7963 | 42 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 18288792 | ||
| CHEMBL270948 | 7963 | 42 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 18288792 | ||
| 10376 | 9704 | 4 | None | 1 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 398 | 6 | 1 | 5 | 5.5 | CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC | 21865047 | ||
| 9801039 | 9704 | 4 | None | 1 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 398 | 6 | 1 | 5 | 5.5 | CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC | 21865047 | ||
| CHEMBL1819077 | 9704 | 4 | None | 1 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 398 | 6 | 1 | 5 | 5.5 | CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC | 21865047 | ||
| 16133798 | 7294 | 0 | None | -1 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | Guide to Pharmacology | None | None | None | None | 12361401 | ||||
| 925 | 7294 | 0 | None | -1 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | Guide to Pharmacology | None | None | None | None | 12361401 | ||||
| 3495 | 7958 | 28 | None | 14 | 2 | Rat | 9.9 | pIC50 | = | 9.9 | Functional | Guide to Pharmacology | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 8874139 | ||
| 5311055 | 7958 | 28 | None | 14 | 2 | Rat | 9.9 | pIC50 | = | 9.9 | Functional | Guide to Pharmacology | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 8874139 | ||
| CHEMBL9946 | 7958 | 28 | None | 14 | 2 | Rat | 9.9 | pIC50 | = | 9.9 | Functional | Guide to Pharmacology | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 8874139 | ||
| 10335 | 7295 | 0 | None | -389 | 2 | Human | 6.3 | pIC50 | > | 6.3 | Functional | Guide to Pharmacology | None | None | None | None | 12361401 | ||||
| 90488758 | 7295 | 0 | None | -389 | 2 | Human | 6.3 | pIC50 | > | 6.3 | Functional | Guide to Pharmacology | None | None | None | None | 12361401 | ||||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| CHEMBL264275 | 217390 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL442112 | 220685 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL263862 | 217375 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL427923 | 220173 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL427811 | 220165 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL437089 | 220483 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL438391 | 220547 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL414130 | 219891 | 0 | None | - | 0 | Mouse | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL439883 | 220628 | 0 | None | - | 1 | Mouse | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL438220 | 220535 | 0 | None | - | 0 | Mouse | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL410568 | 219605 | 0 | None | - | 0 | Mouse | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| 44362115 | 7952 | 0 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm049490m | |||||
| 6967 | 7952 | 0 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm049490m | |||||
| CHEMBL1201609 | 7952 | 0 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm049490m | |||||
| CHEMBL440057 | 7952 | 0 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm049490m | |||||
| CHEMBL428127 | 220196 | 0 | None | - | 0 | Mouse | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL415130 | 219949 | 0 | None | - | 0 | Mouse | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL438601 | 220561 | 0 | None | - | 0 | Mouse | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL412296 | 219761 | 0 | None | - | 0 | Mouse | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL429403 | 220307 | 0 | None | - | 0 | Mouse | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL427611 | 220134 | 0 | None | - | 0 | Mouse | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL428809 | 220253 | 0 | None | - | 0 | Mouse | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL268549 | 217537 | 0 | None | - | 0 | Mouse | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL428296 | 220214 | 0 | None | - | 0 | Mouse | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL409748 | 219560 | 0 | None | - | 0 | Mouse | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL427792 | 220162 | 0 | None | - | 0 | Mouse | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL438760 | 220573 | 0 | None | - | 0 | Mouse | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL413414 | 219843 | 0 | None | - | 0 | Mouse | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL267635 | 217505 | 0 | None | - | 0 | Mouse | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL429547 | 220318 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL410814 | 219623 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL429719 | 220322 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL438210 | 220533 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL411590 | 219729 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL438948 | 220595 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL438928 | 220591 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL412026 | 219750 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL437289 | 220494 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL439102 | 220601 | 0 | None | - | 0 | Mouse | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL438939 | 220594 | 0 | None | - | 0 | Mouse | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL428824 | 220256 | 0 | None | - | 0 | Mouse | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL436912 | 220475 | 0 | None | - | 0 | Mouse | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL436914 | 220476 | 0 | None | - | 0 | Mouse | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL430078 | 220387 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL441929 | 220681 | 0 | None | - | 0 | Mouse | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL414711 | 219927 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| CHEMBL410347 | 219592 | 0 | None | - | 0 | Mouse | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1021/jm049490m | |||||
| 44596586 | 205555 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 398 | 7 | 1 | 6 | 4.6 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1021/jm900716v | |||
| CHEMBL583153 | 205555 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 398 | 7 | 1 | 6 | 4.6 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1021/jm900716v | |||
| 44596589 | 204943 | 3 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 414 | 8 | 1 | 7 | 3.9 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1021/jm900716v | |||
| CHEMBL574852 | 204943 | 3 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 414 | 8 | 1 | 7 | 3.9 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1021/jm900716v | |||
| 44596589 | 204943 | 3 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 414 | 8 | 1 | 7 | 3.9 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL574852 | 204943 | 3 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 414 | 8 | 1 | 7 | 3.9 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| 44194976 | 202713 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 377 | 7 | 1 | 6 | 3.9 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL559437 | 202713 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 377 | 7 | 1 | 6 | 3.9 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| 44194976 | 202713 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 377 | 7 | 1 | 6 | 3.9 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL559437 | 202713 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 377 | 7 | 1 | 6 | 3.9 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| 44194976 | 202713 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 377 | 7 | 1 | 6 | 3.9 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900302q | |||
| CHEMBL559437 | 202713 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 377 | 7 | 1 | 6 | 3.9 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900302q | |||
| 44190059 | 202028 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.6 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL551033 | 202028 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.6 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| 44596809 | 205670 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 362 | 6 | 1 | 6 | 4.0 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1021/jm900716v | |||
| CHEMBL584343 | 205670 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 362 | 6 | 1 | 6 | 4.0 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1021/jm900716v | |||
| 44596589 | 204943 | 3 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 414 | 8 | 1 | 7 | 3.9 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL574852 | 204943 | 3 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 414 | 8 | 1 | 7 | 3.9 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2016.03.067 | |||
| 44190148 | 202785 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 377 | 7 | 1 | 6 | 3.9 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL560036 | 202785 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 377 | 7 | 1 | 6 | 3.9 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| 44596812 | 205583 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 384 | 6 | 1 | 6 | 4.2 | Cc1cc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)nc1OC(F)F | 10.1021/jm900716v | |||
| CHEMBL583387 | 205583 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 384 | 6 | 1 | 6 | 4.2 | Cc1cc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)nc1OC(F)F | 10.1021/jm900716v | |||
| 44596812 | 205583 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 384 | 6 | 1 | 6 | 4.2 | Cc1cc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)nc1OC(F)F | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL583387 | 205583 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 384 | 6 | 1 | 6 | 4.2 | Cc1cc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)nc1OC(F)F | 10.1016/j.bmcl.2010.01.129 | |||
| 11420978 | 18536 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 402 | 7 | 1 | 5 | 4.8 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL1181645 | 18536 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 402 | 7 | 1 | 5 | 4.8 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL187073 | 18536 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 402 | 7 | 1 | 5 | 4.8 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)cc1Cl | 10.1021/jm049737f | |||
| 44190143 | 201620 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 347 | 5 | 1 | 5 | 4.2 | COc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1021/jm900301y | |||
| CHEMBL539670 | 201620 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 347 | 5 | 1 | 5 | 4.2 | COc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1021/jm900301y | |||
| 44190143 | 201620 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 347 | 5 | 1 | 5 | 4.2 | COc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1021/jm900302q | |||
| CHEMBL539670 | 201620 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 347 | 5 | 1 | 5 | 4.2 | COc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1021/jm900302q | |||
| 44190915 | 202783 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 401 | 6 | 1 | 5 | 5.3 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL560033 | 202783 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 401 | 6 | 1 | 5 | 5.3 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 71580213 | 95207 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 9 | 1 | 6 | 4.2 | COc1cc(C)c(Nc2nc(Cl)cn([C@@H](COCCF)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL2349558 | 95207 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 9 | 1 | 6 | 4.2 | COc1cc(C)c(Nc2nc(Cl)cn([C@@H](COCCF)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2013.02.009 | |||
| 71580215 | 95209 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 493 | 9 | 1 | 6 | 5.0 | COc1cc(Cl)c(Nc2nc(Br)cn([C@@H](COCCF)C3CC3)c2=O)c(Cl)c1 | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL2349560 | 95209 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 493 | 9 | 1 | 6 | 5.0 | COc1cc(Cl)c(Nc2nc(Br)cn([C@@H](COCCF)C3CC3)c2=O)c(Cl)c1 | 10.1016/j.bmcl.2013.02.009 | |||
| 44190828 | 203088 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 423 | 6 | 1 | 5 | 5.5 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL562218 | 203088 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 423 | 6 | 1 | 5 | 5.5 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 11384238 | 73624 | 0 | None | - | 1 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 406 | 6 | 1 | 4 | 5.4 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL186203 | 73624 | 0 | None | - | 1 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 406 | 6 | 1 | 4 | 5.4 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049737f | |||
| 44596588 | 204643 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 414 | 8 | 1 | 7 | 3.9 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1021/jm900716v | |||
| CHEMBL572589 | 204643 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 414 | 8 | 1 | 7 | 3.9 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1021/jm900716v | |||
| 9931946 | 18542 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 420 | 7 | 1 | 5 | 4.9 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1cc(F)c(OC)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL1181679 | 18542 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 420 | 7 | 1 | 5 | 4.9 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1cc(F)c(OC)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL188464 | 18542 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 420 | 7 | 1 | 5 | 4.9 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1cc(F)c(OC)cc1Cl | 10.1021/jm049737f | |||
| 45266992 | 202855 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.6 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL560634 | 202855 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.6 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| 44190242 | 201988 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.6 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(Cl)cc2Cl)c1=O | 10.1021/jm900301y | |||
| CHEMBL550686 | 201988 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.6 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(Cl)cc2Cl)c1=O | 10.1021/jm900301y | |||
| 44190242 | 201988 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.6 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(Cl)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL550686 | 201988 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.6 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(Cl)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 44190144 | 202244 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 365 | 7 | 1 | 6 | 3.9 | CC[C@H](COC)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL552504 | 202244 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 365 | 7 | 1 | 6 | 3.9 | CC[C@H](COC)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| 71580214 | 95208 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 449 | 9 | 1 | 6 | 4.9 | COc1cc(Cl)c(Nc2nc(Cl)cn([C@@H](COCCF)C3CC3)c2=O)c(Cl)c1 | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL2349559 | 95208 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 449 | 9 | 1 | 6 | 4.9 | COc1cc(Cl)c(Nc2nc(Cl)cn([C@@H](COCCF)C3CC3)c2=O)c(Cl)c1 | 10.1016/j.bmcl.2013.02.009 | |||
| 71580426 | 95218 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 345 | 6 | 1 | 5 | 3.8 | COc1cc(C)c(Nc2nc(C)cn([C@@H](CF)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL2349570 | 95218 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 345 | 6 | 1 | 5 | 3.8 | COc1cc(C)c(Nc2nc(C)cn([C@@H](CF)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2013.02.009 | |||
| 44190058 | 202823 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 377 | 8 | 1 | 5 | 5.4 | CCCC(CCC)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL560350 | 202823 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 377 | 8 | 1 | 5 | 5.4 | CCCC(CCC)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| 44190446 | 203457 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 379 | 4 | 0 | 5 | 4.2 | COc1cc(Cl)c2c(c1)CCN2c1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1021/jm900301y | |||
| CHEMBL564588 | 203457 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 379 | 4 | 0 | 5 | 4.2 | COc1cc(Cl)c2c(c1)CCN2c1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1021/jm900301y | |||
| 44189950 | 203288 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 345 | 5 | 1 | 4 | 4.9 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL563489 | 203288 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 345 | 5 | 1 | 4 | 4.9 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| 44189950 | 203288 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 345 | 5 | 1 | 4 | 4.9 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900302q | |||
| CHEMBL563489 | 203288 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 345 | 5 | 1 | 4 | 4.9 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900302q | |||
| 56961965 | 88772 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 425 | 8 | 1 | 7 | 3.2 | COCC(COC)n1cc(Br)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL2165202 | 88772 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 425 | 8 | 1 | 7 | 3.2 | COCC(COC)n1cc(Br)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| 46881748 | 13697 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 361 | 5 | 1 | 6 | 3.7 | Cc1cc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)nc1N(C)C | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1084423 | 13697 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 361 | 5 | 1 | 6 | 3.7 | Cc1cc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)nc1N(C)C | 10.1016/j.bmcl.2010.01.129 | |||
| 10027220 | 73639 | 0 | None | - | 1 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 458 | 7 | 1 | 4 | 6.0 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Br | 10.1021/jm049737f | |||
| CHEMBL186252 | 73639 | 0 | None | - | 1 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 458 | 7 | 1 | 4 | 6.0 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Br | 10.1021/jm049737f | |||
| 44610627 | 146753 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 9 | 2 | 8 | 5.5 | Cc1cc(Nc2nc(Cl)cn([C@H](COC(=O)Nc3ccccc3)C3CC3)c2=O)c(C)nc1OC(F)F | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3799870 | 146753 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 9 | 2 | 8 | 5.5 | Cc1cc(Nc2nc(Cl)cn([C@H](COC(=O)Nc3ccccc3)C3CC3)c2=O)c(C)nc1OC(F)F | 10.1016/j.bmcl.2016.03.067 | |||
| 46881834 | 14514 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 400 | 8 | 1 | 7 | 3.5 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2ccc(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1089036 | 14514 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 400 | 8 | 1 | 7 | 3.5 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2ccc(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| 44190057 | 202327 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 349 | 6 | 1 | 5 | 4.6 | CCC(CC)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL554517 | 202327 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 349 | 6 | 1 | 5 | 4.6 | CCC(CC)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| 45483573 | 204944 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 395 | 6 | 1 | 7 | 3.8 | Cc1nc(OC(F)F)c(C#N)cc1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1021/jm900716v | |||
| CHEMBL574853 | 204944 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 395 | 6 | 1 | 7 | 3.8 | Cc1nc(OC(F)F)c(C#N)cc1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1021/jm900716v | |||
| 10363553 | 73600 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 399 | 8 | 1 | 7 | 3.5 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)nc1OC | 10.1021/jm0611410 | |||
| CHEMBL186097 | 73600 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 399 | 8 | 1 | 7 | 3.5 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)nc1OC | 10.1021/jm0611410 | |||
| 10363553 | 73600 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 399 | 8 | 1 | 7 | 3.5 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)nc1OC | 10.1021/jm049737f | |||
| CHEMBL186097 | 73600 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 399 | 8 | 1 | 7 | 3.5 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)nc1OC | 10.1021/jm049737f | |||
| 45483574 | 204813 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 425 | 8 | 1 | 8 | 3.4 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C#N)c(OC(F)F)nc2C)c1=O | 10.1021/jm900716v | |||
| CHEMBL573978 | 204813 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 425 | 8 | 1 | 8 | 3.4 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C#N)c(OC(F)F)nc2C)c1=O | 10.1021/jm900716v | |||
| 44190145 | 201987 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 351 | 6 | 1 | 6 | 3.5 | COC[C@@H](C)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL550685 | 201987 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 351 | 6 | 1 | 6 | 3.5 | COC[C@@H](C)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| 46891155 | 14008 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 342 | 6 | 1 | 6 | 3.7 | CCC(C1CC1)n1nc(C)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1085753 | 14008 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 342 | 6 | 1 | 6 | 3.7 | CCC(C1CC1)n1nc(C)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 44191013 | 203027 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 391 | 4 | 1 | 4 | 5.6 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL561758 | 203027 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 391 | 4 | 1 | 4 | 5.6 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 11752878 | 19035 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 414 | 7 | 1 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL1184703 | 19035 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 414 | 7 | 1 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL364883 | 19035 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 414 | 7 | 1 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Cl | 10.1021/jm049737f | |||
| 11417694 | 74227 | 0 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 382 | 7 | 1 | 5 | 4.4 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)cc1C | 10.1021/jm0611410 | |||
| CHEMBL189089 | 74227 | 0 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 382 | 7 | 1 | 5 | 4.4 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)cc1C | 10.1021/jm0611410 | |||
| 11417694 | 74227 | 0 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 382 | 7 | 1 | 5 | 4.4 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)cc1C | 10.1021/jm049737f | |||
| CHEMBL189089 | 74227 | 0 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 382 | 7 | 1 | 5 | 4.4 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)cc1C | 10.1021/jm049737f | |||
| 44190447 | 203083 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 423 | 4 | 0 | 5 | 4.3 | COc1cc(Br)c2c(c1)CCN2c1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1021/jm900301y | |||
| CHEMBL562161 | 203083 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 423 | 4 | 0 | 5 | 4.3 | COc1cc(Br)c2c(c1)CCN2c1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1021/jm900301y | |||
| 44191012 | 203015 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 351 | 4 | 1 | 4 | 4.9 | Cc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(Cl)c1 | 10.1021/jm900302q | |||
| CHEMBL561698 | 203015 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 351 | 4 | 1 | 4 | 4.9 | Cc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(Cl)c1 | 10.1021/jm900302q | |||
| 42618183 | 186592 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 393 | 8 | 0 | 7 | 3.9 | C=CCN(CC=C)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL474498 | 186592 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 393 | 8 | 0 | 7 | 3.9 | C=CCN(CC=C)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 42618197 | 191085 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 391 | 6 | 1 | 6 | 4.8 | CCC(CC)Nc1nc(C)nc2c(-c3cc(F)c(OC)cc3Cl)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL484158 | 191085 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 391 | 6 | 1 | 6 | 4.8 | CCC(CC)Nc1nc(C)nc2c(-c3cc(F)c(OC)cc3Cl)c(C)nn12 | 10.1021/jm9000242 | |||
| 44194975 | 203089 | 16 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 423 | 6 | 1 | 5 | 5.5 | C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL562219 | 203089 | 16 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 423 | 6 | 1 | 5 | 5.5 | C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 71580425 | 95217 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 365 | 6 | 1 | 5 | 4.2 | COc1cc(C)c(Nc2nc(Cl)cn([C@@H](CF)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL2349569 | 95217 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 365 | 6 | 1 | 5 | 4.2 | COc1cc(C)c(Nc2nc(Cl)cn([C@@H](CF)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2013.02.009 | |||
| 44596808 | 205019 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 378 | 7 | 1 | 7 | 3.3 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1021/jm900716v | |||
| CHEMBL575491 | 205019 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 378 | 7 | 1 | 7 | 3.3 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1021/jm900716v | |||
| 46891337 | 13182 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 395 | 8 | 1 | 8 | 2.9 | COCC(C1CC1)n1nc(C)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082349 | 13182 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 395 | 8 | 1 | 8 | 2.9 | COCC(C1CC1)n1nc(C)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 46891439 | 13839 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 395 | 8 | 1 | 8 | 2.9 | COC[C@@H](C1CC1)n1nc(C)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1084987 | 13839 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 395 | 8 | 1 | 8 | 2.9 | COC[C@@H](C1CC1)n1nc(C)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 44190826 | 201599 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 387 | 5 | 1 | 5 | 4.9 | COc1cc(Cl)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(Cl)c1 | 10.1021/jm900301y | |||
| CHEMBL539184 | 201599 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 387 | 5 | 1 | 5 | 4.9 | COc1cc(Cl)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(Cl)c1 | 10.1021/jm900301y | |||
| 44190826 | 201599 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 387 | 5 | 1 | 5 | 4.9 | COc1cc(Cl)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(Cl)c1 | 10.1021/jm900302q | |||
| CHEMBL539184 | 201599 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 387 | 5 | 1 | 5 | 4.9 | COc1cc(Cl)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(Cl)c1 | 10.1021/jm900302q | |||
| 42618199 | 190943 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 437 | 9 | 0 | 8 | 3.3 | COCCN(CCOC)c1nc(C)nc2c(-c3cc(F)c(OC)cc3Cl)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL482982 | 190943 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 437 | 9 | 0 | 8 | 3.3 | COCCN(CCOC)c1nc(C)nc2c(-c3cc(F)c(OC)cc3Cl)c(C)nn12 | 10.1021/jm9000242 | |||
| 42618197 | 191085 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 391 | 6 | 1 | 6 | 4.8 | CCC(CC)Nc1nc(C)nc2c(-c3cc(F)c(OC)cc3Cl)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL484158 | 191085 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 391 | 6 | 1 | 6 | 4.8 | CCC(CC)Nc1nc(C)nc2c(-c3cc(F)c(OC)cc3Cl)c(C)nn12 | 10.1021/jm9000242 | |||
| 3499 | 8230 | 28 | None | - | 1 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1016/j.bmcl.2016.03.067 | |||
| 9909468 | 8230 | 28 | None | - | 1 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL44698 | 8230 | 28 | None | - | 1 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1016/j.bmcl.2016.03.067 | |||
| 127047546 | 146436 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 441 | 8 | 1 | 8 | 4.1 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COc3ccccn3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3797830 | 146436 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 441 | 8 | 1 | 8 | 4.1 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COc3ccccn3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 46881792 | 14106 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 402 | 5 | 1 | 6 | 4.3 | COc1nc(C(F)(F)F)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1086179 | 14106 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 402 | 5 | 1 | 6 | 4.3 | COc1nc(C(F)(F)F)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2010.01.129 | |||
| 46881793 | 14108 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 370 | 6 | 1 | 6 | 3.9 | Cc1nc(OC(F)F)ccc1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1086180 | 14108 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 370 | 6 | 1 | 6 | 3.9 | Cc1nc(OC(F)F)ccc1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| 46881835 | 14515 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 400 | 8 | 1 | 7 | 3.5 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2ccc(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1089037 | 14515 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 400 | 8 | 1 | 7 | 3.5 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2ccc(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| 44190149 | 201839 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 396 | 5 | 1 | 5 | 5.2 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900301y | |||
| CHEMBL549538 | 201839 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 396 | 5 | 1 | 5 | 5.2 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900301y | |||
| 44190450 | 202437 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 432 | 5 | 1 | 6 | 4.1 | COc1ccc(Nc2nc(Br)cn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1021/jm900301y | |||
| CHEMBL556462 | 202437 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 432 | 5 | 1 | 6 | 4.1 | COc1ccc(Nc2nc(Br)cn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1021/jm900301y | |||
| CHEMBL1077301 | 215270 | 0 | None | - | 2 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](C)C(N)=O | 10.1016/j.bmcl.2010.01.129 | |||||
| 42618181 | 191137 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 369 | 6 | 0 | 7 | 3.6 | CCN(CC)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL484420 | 191137 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 369 | 6 | 0 | 7 | 3.6 | CCN(CC)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 3499 | 8230 | 28 | None | - | 1 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm900302q | |||
| 9909468 | 8230 | 28 | None | - | 1 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm900302q | |||
| CHEMBL44698 | 8230 | 28 | None | - | 1 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm900302q | |||
| 44190149 | 201839 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 396 | 5 | 1 | 5 | 5.2 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL549538 | 201839 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 396 | 5 | 1 | 5 | 5.2 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 44190829 | 202080 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 371 | 4 | 1 | 4 | 5.2 | Cc1cc(Cl)cc(Cl)c1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1021/jm900302q | |||
| CHEMBL551433 | 202080 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 371 | 4 | 1 | 4 | 5.2 | Cc1cc(Cl)cc(Cl)c1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1021/jm900302q | |||
| 44190913 | 202724 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.6 | CCOc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1021/jm900302q | |||
| CHEMBL559507 | 202724 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.6 | CCOc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1021/jm900302q | |||
| 11246513 | 73634 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.6 | CCCN(CCC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C#N)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL186241 | 73634 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.6 | CCCN(CCC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C#N)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL526149 | 222454 | 10 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm9000242 | |||||
| 44629380 | 146664 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 508 | 8 | 2 | 9 | 4.7 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)Nc3cccc(C#N)c3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3799337 | 146664 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 508 | 8 | 2 | 9 | 4.7 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)Nc3cccc(C#N)c3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 44189947 | 201879 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.2 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL549875 | 201879 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.2 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| 44191008 | 203036 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 439 | 5 | 1 | 4 | 6.3 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL561819 | 203036 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 439 | 5 | 1 | 4 | 6.3 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 45483576 | 205144 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 425 | 8 | 1 | 8 | 3.4 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C#N)c(OC(F)F)nc2C)c1=O | 10.1021/jm900716v | |||
| CHEMBL576589 | 205144 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 425 | 8 | 1 | 8 | 3.4 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C#N)c(OC(F)F)nc2C)c1=O | 10.1021/jm900716v | |||
| 44189951 | 201806 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 349 | 6 | 1 | 5 | 4.2 | CC[C@H](COC)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL549329 | 201806 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 349 | 6 | 1 | 5 | 4.2 | CC[C@H](COC)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| 44591500 | 196511 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 395 | 7 | 0 | 7 | 4.1 | CCCN(c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12)C1CC1 | 10.1021/jm9000242 | |||
| CHEMBL515740 | 196511 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 395 | 7 | 0 | 7 | 4.1 | CCCN(c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12)C1CC1 | 10.1021/jm9000242 | |||
| 44596810 | 204781 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 348 | 5 | 1 | 6 | 3.6 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1021/jm900716v | |||
| CHEMBL573748 | 204781 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 348 | 5 | 1 | 6 | 3.6 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1021/jm900716v | |||
| 44596807 | 204876 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 378 | 7 | 1 | 7 | 3.3 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1021/jm900716v | |||
| CHEMBL574436 | 204876 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 378 | 7 | 1 | 7 | 3.3 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1021/jm900716v | |||
| 44629379 | 146463 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 517 | 8 | 2 | 8 | 5.5 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)Nc3ccccc3Cl)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3797992 | 146463 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 517 | 8 | 2 | 8 | 5.5 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)Nc3ccccc3Cl)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 44629309 | 146597 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 483 | 8 | 2 | 8 | 4.9 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)Nc3ccccc3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3798885 | 146597 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 483 | 8 | 2 | 8 | 4.9 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)Nc3ccccc3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 127047519 | 146686 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 468 | 8 | 1 | 8 | 4.5 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)c3ccccc3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3799452 | 146686 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 468 | 8 | 1 | 8 | 4.5 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)c3ccccc3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 127047547 | 146855 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 519 | 8 | 1 | 8 | 4.8 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COc3cc(Br)ccn3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3800497 | 146855 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 519 | 8 | 1 | 8 | 4.8 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COc3cc(Br)ccn3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 44596807 | 204876 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 378 | 7 | 1 | 7 | 3.3 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL574436 | 204876 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 378 | 7 | 1 | 7 | 3.3 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1016/j.bmcl.2016.03.067 | |||
| 44190340 | 202249 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 373 | 6 | 0 | 4 | 5.3 | CC[C@H](C1CC1)n1cc(Cl)nc(N(CC)c2cc(C)c(C)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL552559 | 202249 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 373 | 6 | 0 | 4 | 5.3 | CC[C@H](C1CC1)n1cc(Cl)nc(N(CC)c2cc(C)c(C)cc2C)c1=O | 10.1021/jm900301y | |||
| 44190337 | 202912 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 391 | 8 | 1 | 6 | 4.3 | CCOc1cc(C)c(Nc2nc(Cl)cn([C@@H](COC)C3CC3)c2=O)cc1C | 10.1021/jm900301y | |||
| CHEMBL561097 | 202912 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 391 | 8 | 1 | 6 | 4.3 | CCOc1cc(C)c(Nc2nc(Cl)cn([C@@H](COC)C3CC3)c2=O)cc1C | 10.1021/jm900301y | |||
| 44596810 | 204781 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 348 | 5 | 1 | 6 | 3.6 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL573748 | 204781 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 348 | 5 | 1 | 6 | 3.6 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2010.01.129 | |||
| 11211931 | 131121 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 406 | 5 | 1 | 5 | 4.5 | CCN(c1cc(C)nc2c1NC(=O)CN2c1cc(F)c(OC)cc1Cl)C(C)C | 10.1021/jm049737f | |||
| CHEMBL363654 | 131121 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 406 | 5 | 1 | 5 | 4.5 | CCN(c1cc(C)nc2c1NC(=O)CN2c1cc(F)c(OC)cc1Cl)C(C)C | 10.1021/jm049737f | |||
| 54582097 | 67813 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 372 | 7 | 0 | 7 | 3.3 | CCN(CCCF)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1016/j.bmcl.2011.02.050 | |||
| CHEMBL1762820 | 67813 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 372 | 7 | 0 | 7 | 3.3 | CCN(CCCF)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1016/j.bmcl.2011.02.050 | |||
| 44596587 | 204642 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 388 | 7 | 1 | 7 | 3.5 | COC[C@@H](C)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1021/jm900716v | |||
| CHEMBL572588 | 204642 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 388 | 7 | 1 | 7 | 3.5 | COC[C@@H](C)n1cc(Cl)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1021/jm900716v | |||
| 127047548 | 146464 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 509 | 8 | 1 | 8 | 5.1 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COc3ccc(C(F)(F)F)cn3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3798004 | 146464 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 509 | 8 | 1 | 8 | 5.1 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COc3ccc(C(F)(F)F)cn3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 44629378 | 146612 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 517 | 8 | 2 | 8 | 5.5 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)Nc3ccc(Cl)cc3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3799036 | 146612 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 517 | 8 | 2 | 8 | 5.5 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)Nc3ccc(Cl)cc3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 44190449 | 202756 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 388 | 5 | 1 | 6 | 4.0 | COc1ccc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL559764 | 202756 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 388 | 5 | 1 | 6 | 4.0 | COc1ccc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.01.129 | |||
| 42618230 | 198117 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 380 | 7 | 0 | 7 | 3.7 | CCCN(CC1CC1)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL519159 | 198117 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 380 | 7 | 0 | 7 | 3.7 | CCCN(CC1CC1)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 44191010 | 201926 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 455 | 6 | 1 | 5 | 5.6 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL550216 | 201926 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 455 | 6 | 1 | 5 | 5.6 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 42618198 | 190942 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 377 | 5 | 0 | 6 | 4.1 | CCN(CC)c1nc(C)nc2c(-c3cc(F)c(OC)cc3Cl)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL482981 | 190942 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 377 | 5 | 0 | 6 | 4.1 | CCN(CC)c1nc(C)nc2c(-c3cc(F)c(OC)cc3Cl)c(C)nn12 | 10.1021/jm9000242 | |||
| 44596701 | 204812 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 353 | 6 | 1 | 7 | 3.2 | CC[C@H](C1CC1)n1cc(C#N)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1021/jm900716v | |||
| CHEMBL573976 | 204812 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 353 | 6 | 1 | 7 | 3.2 | CC[C@H](C1CC1)n1cc(C#N)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1021/jm900716v | |||
| 44629377 | 146743 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 551 | 8 | 2 | 8 | 6.2 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)Nc3cc(Cl)cc(Cl)c3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3799825 | 146743 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 551 | 8 | 2 | 8 | 6.2 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)Nc3cc(Cl)cc(Cl)c3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 44629312 | 146839 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 551 | 8 | 2 | 8 | 6.2 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)Nc3ccc(Cl)cc3Cl)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3800413 | 146839 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 551 | 8 | 2 | 8 | 6.2 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)Nc3ccc(Cl)cc3Cl)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 44190145 | 201987 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 351 | 6 | 1 | 6 | 3.5 | COC[C@@H](C)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL550685 | 201987 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 351 | 6 | 1 | 6 | 3.5 | COC[C@@H](C)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| 44189946 | 202607 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 331 | 4 | 1 | 4 | 4.5 | Cc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)c1 | 10.1016/j.bmcl.2010.01.129 | |||
| 44189946 | 202607 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 331 | 4 | 1 | 4 | 4.5 | Cc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)c1 | 10.1021/jm900301y | |||
| CHEMBL558280 | 202607 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 331 | 4 | 1 | 4 | 4.5 | Cc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)c1 | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL558280 | 202607 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 331 | 4 | 1 | 4 | 4.5 | Cc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)c1 | 10.1021/jm900301y | |||
| 44189946 | 202607 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 331 | 4 | 1 | 4 | 4.5 | Cc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)c1 | 10.1021/jm900302q | |||
| CHEMBL558280 | 202607 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 331 | 4 | 1 | 4 | 4.5 | Cc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)c1 | 10.1021/jm900302q | |||
| 44190918 | 202784 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 400 | 6 | 1 | 6 | 4.4 | CC[C@H](COC)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL560034 | 202784 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 400 | 6 | 1 | 6 | 4.4 | CC[C@H](COC)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 42618187 | 186943 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 397 | 8 | 0 | 7 | 4.4 | CCCCN(CC)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL474901 | 186943 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 397 | 8 | 0 | 7 | 4.4 | CCCCN(CC)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 42618188 | 186057 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 399 | 8 | 0 | 8 | 3.2 | CCN(CCOC)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL473075 | 186057 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 399 | 8 | 0 | 8 | 3.2 | CCN(CCOC)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 44190449 | 202756 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 388 | 5 | 1 | 6 | 4.0 | COc1ccc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1021/jm900301y | |||
| CHEMBL559764 | 202756 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 388 | 5 | 1 | 6 | 4.0 | COc1ccc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1021/jm900301y | |||
| 42618189 | 196469 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 425 | 9 | 0 | 8 | 3.6 | COCCN(CC1CC1)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL515396 | 196469 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 425 | 9 | 0 | 8 | 3.6 | COCCN(CC1CC1)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 44190823 | 202976 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 455 | 6 | 1 | 5 | 6.2 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL561416 | 202976 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 455 | 6 | 1 | 5 | 6.2 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 11154464 | 74244 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 423 | 6 | 1 | 5 | 5.0 | CCCN(CC1CCC1)c1cc(C)nc2c1NC(=O)CN2c1ccc(C#N)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL189196 | 74244 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 423 | 6 | 1 | 5 | 5.0 | CCCN(CC1CCC1)c1cc(C)nc2c1NC(=O)CN2c1ccc(C#N)cc1Cl | 10.1021/jm049737f | |||
| 42618172 | 186777 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 376 | 6 | 0 | 7 | 3.6 | COc1ccc(-c2c(C)nn3c(N(CCC#N)C4CC4)nc(C)nc23)c(C)c1 | 10.1021/jm9000242 | |||
| CHEMBL474701 | 186777 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 376 | 6 | 0 | 7 | 3.6 | COc1ccc(-c2c(C)nn3c(N(CCC#N)C4CC4)nc(C)nc23)c(C)c1 | 10.1021/jm9000242 | |||
| 52918270 | 67814 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 402 | 9 | 0 | 8 | 2.9 | COCCN(CCCF)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1016/j.bmcl.2011.02.050 | |||
| CHEMBL1762821 | 67814 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 402 | 9 | 0 | 8 | 2.9 | COCCN(CCCF)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1016/j.bmcl.2011.02.050 | |||
| 44629381 | 146738 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 520 | 9 | 2 | 9 | 4.8 | Cc1cc(Nc2nc(Cl)cn([C@H](COC(=O)Nc3cccnc3)C3CC3)c2=O)c(C)nc1OC(F)F | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3799784 | 146738 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 520 | 9 | 2 | 9 | 4.8 | Cc1cc(Nc2nc(Cl)cn([C@H](COC(=O)Nc3cccnc3)C3CC3)c2=O)c(C)nc1OC(F)F | 10.1016/j.bmcl.2016.03.067 | |||
| 42618196 | 198252 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 371 | 6 | 1 | 6 | 4.5 | CCC(CC)Nc1nc(C)nc2c(-c3cc(F)c(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL519340 | 198252 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 371 | 6 | 1 | 6 | 4.5 | CCC(CC)Nc1nc(C)nc2c(-c3cc(F)c(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 42618170 | 187618 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 379 | 7 | 0 | 6 | 4.4 | CCCN(CC1CC1)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL475706 | 187618 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 379 | 7 | 0 | 6 | 4.4 | CCCN(CC1CC1)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 42618195 | 191065 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 413 | 9 | 0 | 8 | 3.1 | COCCN(CCOC)c1nc(C)nc2c(-c3cc(C)c(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL483993 | 191065 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 413 | 9 | 0 | 8 | 3.1 | COCCN(CCOC)c1nc(C)nc2c(-c3cc(C)c(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 21984762 | 84317 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 409 | 8 | 0 | 4 | 5.9 | CCc1nn2c(-c3ccc(OC)cc3Cl)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087550 | 84317 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 409 | 8 | 0 | 4 | 5.9 | CCc1nn2c(-c3ccc(OC)cc3Cl)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | |||
| 44596702 | 204726 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 339 | 5 | 1 | 7 | 2.9 | COc1nc(C)c(Nc2nc(C#N)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1021/jm900716v | |||
| CHEMBL573284 | 204726 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 339 | 5 | 1 | 7 | 2.9 | COc1nc(C)c(Nc2nc(C#N)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1021/jm900716v | |||
| 46891188 | 13416 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 397 | 4 | 1 | 6 | 4.5 | Cc1nc(Nc2c(Cl)cc(C#N)c(Cl)c2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1083343 | 13416 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 397 | 4 | 1 | 6 | 4.5 | Cc1nc(Nc2c(Cl)cc(C#N)c(Cl)c2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 44629310 | 146676 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 484 | 8 | 2 | 9 | 4.3 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)Nc3cccnc3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3799417 | 146676 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 484 | 8 | 2 | 9 | 4.3 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)Nc3cccnc3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 58280026 | 146860 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 449 | 9 | 2 | 8 | 3.7 | CCCNC(=O)OC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3800523 | 146860 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 449 | 9 | 2 | 8 | 3.7 | CCCNC(=O)OC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1016/j.bmcl.2016.03.067 | |||
| 44190147 | 203523 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 363 | 6 | 2 | 6 | 3.2 | COc1cc(C)c(Nc2nc(Cl)cn([C@@H](CO)C3CC3)c2=O)cc1C | 10.1021/jm900301y | |||
| CHEMBL565169 | 203523 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 363 | 6 | 2 | 6 | 3.2 | COc1cc(C)c(Nc2nc(Cl)cn([C@@H](CO)C3CC3)c2=O)cc1C | 10.1021/jm900301y | |||
| 24768326 | 104552 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 328 | 6 | 0 | 4 | 5.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)nc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL271762 | 104552 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 328 | 6 | 0 | 4 | 5.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)nc2C)c1C | 10.1021/jm070578k | |||
| 10295702 | 129678 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 420 | 6 | 0 | 4 | 5.7 | CCCC(C1CC1)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL360589 | 129678 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 420 | 6 | 0 | 4 | 5.7 | CCCC(C1CC1)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 11306819 | 19180 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.6 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1C#N | 10.1021/jm049737f | |||
| CHEMBL1185802 | 19180 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.6 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1C#N | 10.1021/jm049737f | |||
| CHEMBL433592 | 19180 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.6 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1C#N | 10.1021/jm049737f | |||
| 24768326 | 104552 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 328 | 6 | 0 | 4 | 5.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)nc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL271762 | 104552 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 328 | 6 | 0 | 4 | 5.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)nc2C)c1C | 10.1021/jm070578k | |||
| 9927970 | 104512 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 341 | 7 | 0 | 3 | 6.2 | CCc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1 | 10.1021/jm070578k | |||
| CHEMBL271558 | 104512 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 341 | 7 | 0 | 3 | 6.2 | CCc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1 | 10.1021/jm070578k | |||
| 9819482 | 164326 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 343 | 7 | 0 | 4 | 5.2 | CCC(COC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL408028 | 164326 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 343 | 7 | 0 | 4 | 5.2 | CCC(COC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| 70692631 | 82675 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 378 | 7 | 2 | 4 | 5.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)[nH]c12 | 10.1016/j.ejmech.2021.114085 | |||
| CHEMBL2049190 | 82675 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 378 | 7 | 2 | 4 | 5.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)[nH]c12 | 10.1016/j.ejmech.2021.114085 | |||
| 70692631 | 82675 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 378 | 7 | 2 | 4 | 5.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)[nH]c12 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2049190 | 82675 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 378 | 7 | 2 | 4 | 5.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)[nH]c12 | 10.1016/j.bmcl.2012.05.066 | |||
| 17961227 | 101182 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 483 | 6 | 0 | 3 | 8.2 | CCCC(CCC)n1cc2c3c(nc(C)cc31)N(c1ccc(C(F)(F)F)cc1C(F)(F)F)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL250982 | 101182 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 483 | 6 | 0 | 3 | 8.2 | CCCC(CCC)n1cc2c3c(nc(C)cc31)N(c1ccc(C(F)(F)F)cc1C(F)(F)F)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| 44589204 | 196280 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 384 | 3 | 0 | 7 | 4.3 | Cc1cc(C#N)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| CHEMBL513967 | 196280 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 384 | 3 | 0 | 7 | 4.3 | Cc1cc(C#N)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| 21912321 | 104555 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 327 | 4 | 0 | 4 | 4.6 | Cc1cc(C)c(Oc2nc(C)cc(OC3CCOC3)c2C)c(C)c1 | 10.1021/jm070578k | |||
| CHEMBL271770 | 104555 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 327 | 4 | 0 | 4 | 4.6 | Cc1cc(C)c(Oc2nc(C)cc(OC3CCOC3)c2C)c(C)c1 | 10.1021/jm070578k | |||
| 57785838 | 171884 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 503 | 6 | 0 | 6 | 6.3 | CCc1nc(C)nc(CC)c1N1CCCn2c1nc1c(Cl)ccc(C(OC(F)F)C(F)(F)F)c12 | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4227282 | 171884 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 503 | 6 | 0 | 6 | 6.3 | CCc1nc(C)nc(CC)c1N1CCCn2c1nc1c(Cl)ccc(C(OC(F)F)C(F)(F)F)c12 | 10.1016/j.bmc.2018.01.020 | |||
| 11122528 | 72002 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 413 | 10 | 0 | 7 | 4.0 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2c(OC)cc(OC)cc2OC)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL182643 | 72002 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 413 | 10 | 0 | 7 | 4.0 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2c(OC)cc(OC)cc2OC)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 58223462 | 135588 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 473 | 10 | 0 | 9 | 4.7 | CCCCN(c1c(OC)nn2c(-c3c(OC)cc(C=O)cc3OC)csc12)C1CCOCC1 | nan | |||
| CHEMBL3669429 | 135588 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 473 | 10 | 0 | 9 | 4.7 | CCCCN(c1c(OC)nn2c(-c3c(OC)cc(C=O)cc3OC)csc12)C1CCOCC1 | nan | |||
| 57912458 | 89381 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 487 | 10 | 0 | 9 | 4.6 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)C4CCOCC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| CHEMBL2179184 | 89381 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 487 | 10 | 0 | 9 | 4.6 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)C4CCOCC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| 71458703 | 88290 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 419 | 8 | 0 | 6 | 5.1 | CCN(CC)c1ccc(C#N)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160164 | 88290 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 419 | 8 | 0 | 6 | 5.1 | CCN(CC)c1ccc(C#N)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 24768342 | 92353 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 364 | 6 | 1 | 6 | 4.2 | CCCCN(CC)c1nc(C)nc2c1NCCN2c1ccc(C#N)cc1C | 10.1021/jm0611410 | |||
| CHEMBL228130 | 92353 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 364 | 6 | 1 | 6 | 4.2 | CCCCN(CC)c1nc(C)nc2c1NCCN2c1ccc(C#N)cc1C | 10.1021/jm0611410 | |||
| 21912321 | 104555 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 327 | 4 | 0 | 4 | 4.6 | Cc1cc(C)c(Oc2nc(C)cc(OC3CCOC3)c2C)c(C)c1 | 10.1021/jm070578k | |||
| CHEMBL271770 | 104555 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 327 | 4 | 0 | 4 | 4.6 | Cc1cc(C)c(Oc2nc(C)cc(OC3CCOC3)c2C)c(C)c1 | 10.1021/jm070578k | |||
| 71462234 | 88297 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 452 | 11 | 0 | 6 | 6.0 | CCCN(CCC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160171 | 88297 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 452 | 11 | 0 | 6 | 6.0 | CCCN(CCC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 60155794 | 84337 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 449 | 9 | 0 | 6 | 5.2 | CCc1nn2c(-c3c(OC)cccc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087570 | 84337 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 449 | 9 | 0 | 6 | 5.2 | CCc1nn2c(-c3c(OC)cccc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| 71458705 | 88296 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 438 | 10 | 0 | 6 | 5.5 | CCc1cc2c(N(CC)CC)ccc(OC)c2nc1-c1c(OC)cc(COC)cc1OC | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160170 | 88296 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 438 | 10 | 0 | 6 | 5.5 | CCc1cc2c(N(CC)CC)ccc(OC)c2nc1-c1c(OC)cc(COC)cc1OC | 10.1016/j.bmc.2012.09.028 | |||
| 44392550 | 71342 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 489 | 9 | 0 | 8 | 5.0 | CCCC(CCC)n1c(CC)nc2c1c(=O)n(C)c(=O)n2-c1cc(-c2cccnc2)c(OC)cc1C | 10.1021/jm049787k | |||
| CHEMBL181546 | 71342 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 489 | 9 | 0 | 8 | 5.0 | CCCC(CCC)n1c(CC)nc2c1c(=O)n(C)c(=O)n2-c1cc(-c2cccnc2)c(OC)cc1C | 10.1021/jm049787k | |||
| 70690704 | 83389 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 438 | 10 | 0 | 6 | 5.2 | CCN(CCOC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| CHEMBL2063375 | 83389 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 438 | 10 | 0 | 6 | 5.2 | CCN(CCOC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| 70690704 | 83389 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 438 | 10 | 0 | 6 | 5.2 | CCN(CCOC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2063375 | 83389 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 438 | 10 | 0 | 6 | 5.2 | CCN(CCOC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 21912293 | 104591 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cccc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL271974 | 104591 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cccc2C)c1C | 10.1021/jm070578k | |||
| 21912397 | 104812 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 371 | 8 | 0 | 4 | 6.5 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(OC(C)C)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL273033 | 104812 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 371 | 8 | 0 | 4 | 6.5 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(OC(C)C)cc2C)c1C | 10.1021/jm070578k | |||
| 58896510 | 146286 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 430 | 6 | 1 | 5 | 5.6 | CCN(c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12)C(C)C | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3793568 | 146286 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 430 | 6 | 1 | 5 | 5.6 | CCN(c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12)C(C)C | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3794598 | 146286 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 430 | 6 | 1 | 5 | 5.6 | CCN(c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12)C(C)C | 10.1021/acs.jmedchem.5b01715 | |||
| 46891088 | 13842 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.5 | COCC(C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC(F)(F)F)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1084997 | 13842 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.5 | COCC(C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC(F)(F)F)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 46891035 | 14175 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 436 | 6 | 1 | 6 | 4.6 | COCC(C1CC1)n1nc(C)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1086510 | 14175 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 436 | 6 | 1 | 6 | 4.6 | COCC(C1CC1)n1nc(C)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 46845695 | 13694 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 334 | 5 | 1 | 6 | 3.3 | COc1ccc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)n1 | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1084413 | 13694 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 334 | 5 | 1 | 6 | 3.3 | COc1ccc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)n1 | 10.1016/j.bmcl.2010.01.129 | |||
| 44190917 | 203004 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 429 | 5 | 1 | 5 | 5.2 | COC[C@@H](C)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL561615 | 203004 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 429 | 5 | 1 | 5 | 5.2 | COC[C@@H](C)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 9927970 | 104512 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 341 | 7 | 0 | 3 | 6.2 | CCc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1 | 10.1021/jm070578k | |||
| CHEMBL271558 | 104512 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 341 | 7 | 0 | 3 | 6.2 | CCc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1 | 10.1021/jm070578k | |||
| 9819482 | 164326 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 343 | 7 | 0 | 4 | 5.2 | CCC(COC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL408028 | 164326 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 343 | 7 | 0 | 4 | 5.2 | CCC(COC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| 57785862 | 171720 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 388 | 4 | 0 | 4 | 5.7 | CCN(CC)c1cccc2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4224887 | 171720 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 388 | 4 | 0 | 4 | 5.7 | CCN(CC)c1cccc2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| 3495 | 7958 | 28 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2011.02.086 | |||
| 5311055 | 7958 | 28 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2011.02.086 | |||
| CHEMBL9946 | 7958 | 28 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2011.02.086 | |||
| 42618206 | 186950 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 367 | 6 | 1 | 6 | 4.6 | CCC(CC)Nc1nc(C)nc2c(-c3ccc(OC)c(C)c3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL474907 | 186950 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 367 | 6 | 1 | 6 | 4.6 | CCC(CC)Nc1nc(C)nc2c(-c3ccc(OC)c(C)c3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 42618165 | 181314 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 385 | 9 | 0 | 8 | 2.5 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL455588 | 181314 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 385 | 9 | 0 | 8 | 2.5 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3)c(C)nn12 | 10.1021/jm9000242 | |||
| 24758072 | 76752 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 320 | 4 | 0 | 2 | 6.1 | CCC(CC)c1cc(C)n2nc(-c3ccc(C)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939572 | 76752 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 320 | 4 | 0 | 2 | 6.1 | CCC(CC)c1cc(C)n2nc(-c3ccc(C)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | |||
| 24768331 | 92249 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 369 | 7 | 1 | 6 | 4.3 | CCCCN(CC)c1nc(C)nc2c1NCCN2c1ccc(OC)cc1C | 10.1021/jm0611410 | |||
| CHEMBL226761 | 92249 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 369 | 7 | 1 | 6 | 4.3 | CCCCN(CC)c1nc(C)nc2c1NCCN2c1ccc(OC)cc1C | 10.1021/jm0611410 | |||
| 44362115 | 7952 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0202122 | |||||
| 6967 | 7952 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0202122 | |||||
| CHEMBL1201609 | 7952 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0202122 | |||||
| CHEMBL440057 | 7952 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0202122 | |||||
| 71456850 | 88291 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 424 | 9 | 0 | 6 | 5.2 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160166 | 88291 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 424 | 9 | 0 | 6 | 5.2 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 21912293 | 104591 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cccc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL271974 | 104591 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cccc2C)c1C | 10.1021/jm070578k | |||
| 21912397 | 104812 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 371 | 8 | 0 | 4 | 6.5 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(OC(C)C)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL273033 | 104812 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 371 | 8 | 0 | 4 | 6.5 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(OC(C)C)cc2C)c1C | 10.1021/jm070578k | |||
| 70909662 | 163007 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 448 | 6 | 1 | 5 | 6.1 | CCC(=O)N(c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12)C(C)C | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4064670 | 163007 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 448 | 6 | 1 | 5 | 6.1 | CCC(=O)N(c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12)C(C)C | 10.1016/j.bmc.2016.11.011 | |||
| 137654892 | 165404 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 420 | 7 | 2 | 5 | 6.5 | CCC(CC)Nc1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4092351 | 165404 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 420 | 7 | 2 | 5 | 6.5 | CCC(CC)Nc1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 44129684 | 171809 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 491 | 5 | 0 | 7 | 5.5 | COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc(C(OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4226158 | 171809 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 491 | 5 | 0 | 7 | 5.5 | COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc(C(OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | |||
| 9951076 | 74185 | 2 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 366 | 7 | 0 | 6 | 4.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(N(C)C)nc3)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL188844 | 74185 | 2 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 366 | 7 | 0 | 6 | 4.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(N(C)C)nc3)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL2165204 | 74185 | 2 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 366 | 7 | 0 | 6 | 4.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(N(C)C)nc3)c(C)nn12 | 10.1021/jm040058e | |||
| 10616876 | 108135 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 336 | 5 | 1 | 4 | 5.2 | CCCCNc1nc(C)nc2c1c(C)cn2-c1c(C)cc(C)cc1C | 10.1021/jm960861b | |||
| CHEMBL296977 | 108135 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 336 | 5 | 1 | 4 | 5.2 | CCCCNc1nc(C)nc2c1c(C)cn2-c1c(C)cc(C)cc1C | 10.1021/jm960861b | |||
| 46891338 | 14151 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 346 | 6 | 1 | 9 | 1.8 | COc1nc(C)c(Nc2nc(C)nn(C(C)C3CC3)c2=O)c(OC)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1086374 | 14151 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 346 | 6 | 1 | 9 | 1.8 | COc1nc(C)c(Nc2nc(C)nn(C(C)C3CC3)c2=O)c(OC)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 70888282 | 181916 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 556 | 7 | 1 | 7 | 6.3 | COc1cc(Br)cc(C)c1Nc1nc2cccc(N(c3ccc(S(C)(=O)=O)cc3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4569860 | 181916 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 556 | 7 | 1 | 7 | 6.3 | COc1cc(Br)cc(C)c1Nc1nc2cccc(N(c3ccc(S(C)(=O)=O)cc3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| 54585865 | 67427 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 394 | 6 | 0 | 5 | 4.8 | CCCN(CCC)c1nc2c(c(-c3c(C)cc(C)cc3C)c(C)n2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| CHEMBL1760257 | 67427 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 394 | 6 | 0 | 5 | 4.8 | CCCN(CCC)c1nc2c(c(-c3c(C)cc(C)cc3C)c(C)n2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| 57390211 | 76769 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 395 | 7 | 0 | 5 | 5.3 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC(C)C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939589 | 76769 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 395 | 7 | 0 | 5 | 5.3 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC(C)C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 9800812 | 130414 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 394 | 5 | 0 | 4 | 5.3 | CCc1nc2c(n1C(CC)CC)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL361912 | 130414 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 394 | 5 | 0 | 4 | 5.3 | CCc1nc2c(n1C(CC)CC)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 56659877 | 72080 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 415 | 9 | 1 | 6 | 5.9 | CCCN(CCC)c1c(C(C)C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828892 | 72080 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 415 | 9 | 1 | 6 | 5.9 | CCCN(CCC)c1c(C(C)C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 60155990 | 84353 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 513 | 11 | 0 | 9 | 4.9 | COCc1cc(OC)c(-c2cccc3c(N(CC4CC4)CC4OCCCO4)c(SC)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| CHEMBL2087800 | 84353 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 513 | 11 | 0 | 9 | 4.9 | COCc1cc(OC)c(-c2cccc3c(N(CC4CC4)CC4OCCCO4)c(SC)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| 10111759 | 71130 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 402 | 6 | 0 | 5 | 4.7 | CCc1nc2c(n1C(CC)C1CC1)C(=O)N(C)CN2c1ccc(OC)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL181259 | 71130 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 402 | 6 | 0 | 5 | 4.7 | CCc1nc2c(n1C(CC)C1CC1)C(=O)N(C)CN2c1ccc(OC)cc1Cl | 10.1021/jm049787k | |||
| 44589350 | 196381 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 387 | 3 | 0 | 7 | 3.7 | N#Cc1ccc(N2CCc3c(-n4ccc(-n5cccn5)n4)ccnc32)c(Cl)c1 | 10.1021/jm800743q | |||
| CHEMBL514761 | 196381 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 387 | 3 | 0 | 7 | 3.7 | N#Cc1ccc(N2CCc3c(-n4ccc(-n5cccn5)n4)ccnc32)c(Cl)c1 | 10.1021/jm800743q | |||
| 70696935 | 83384 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 450 | 11 | 0 | 5 | 6.6 | CCCN(CCC)c1ccc(CC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| CHEMBL2063370 | 83384 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 450 | 11 | 0 | 5 | 6.6 | CCCN(CCC)c1ccc(CC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| 58223504 | 134612 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 503 | 11 | 0 | 9 | 5.2 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)c(CC)sc12)C1CCOCC1 | nan | |||
| CHEMBL3664547 | 134612 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 503 | 11 | 0 | 9 | 5.2 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)c(CC)sc12)C1CCOCC1 | nan | |||
| 71455052 | 88293 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 428 | 9 | 0 | 6 | 5.1 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(F)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160168 | 88293 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 428 | 9 | 0 | 6 | 5.1 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(F)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 58896594 | 146282 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 444 | 8 | 1 | 5 | 6.0 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3793367 | 146282 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 444 | 8 | 1 | 5 | 6.0 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3794594 | 146282 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 444 | 8 | 1 | 5 | 6.0 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 56683763 | 72275 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 387 | 8 | 1 | 6 | 5.1 | CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2nccn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830519 | 72275 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 387 | 8 | 1 | 6 | 5.1 | CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2nccn12 | 10.1016/j.bmc.2011.08.055 | |||
| 21984648 | 84319 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 389 | 8 | 0 | 4 | 5.5 | CCc1nn2c(-c3ccc(C)cc3OC)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087552 | 84319 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 389 | 8 | 0 | 4 | 5.5 | CCc1nn2c(-c3ccc(C)cc3OC)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | |||
| 44596700 | 205398 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 369 | 7 | 1 | 8 | 2.5 | COC[C@H](C1CC1)n1cc(C#N)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1021/jm900716v | |||
| CHEMBL578838 | 205398 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 369 | 7 | 1 | 8 | 2.5 | COC[C@H](C1CC1)n1cc(C#N)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1021/jm900716v | |||
| 46891490 | 13240 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 369 | 5 | 1 | 7 | 3.1 | COc1ccc(Nc2nc(C)nn([C@@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082625 | 13240 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 369 | 5 | 1 | 7 | 3.1 | COc1ccc(Nc2nc(C)nn([C@@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 46891233 | 13470 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 383 | 6 | 1 | 7 | 3.5 | CCOc1ccc(Nc2nc(C)nn(C(C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1083592 | 13470 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 383 | 6 | 1 | 7 | 3.5 | CCOc1ccc(Nc2nc(C)nn(C(C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 46845696 | 13161 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 348 | 5 | 1 | 6 | 3.6 | COc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)n1 | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1082241 | 13161 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 348 | 5 | 1 | 6 | 3.6 | COc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)n1 | 10.1016/j.bmcl.2010.01.129 | |||
| 44190054 | 202792 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 335 | 5 | 1 | 5 | 3.8 | COC[C@@H](C)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL560098 | 202792 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 335 | 5 | 1 | 5 | 3.8 | COC[C@@H](C)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| 42618225 | 186082 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 340 | 5 | 0 | 7 | 3.0 | CCN(CC)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL473276 | 186082 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 340 | 5 | 0 | 7 | 3.0 | CCN(CC)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 21912223 | 104361 | 1 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 328 | 6 | 1 | 4 | 5.3 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1N | 10.1021/jm070578k | |||
| CHEMBL270780 | 104361 | 1 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 328 | 6 | 1 | 4 | 5.3 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1N | 10.1021/jm070578k | |||
| 21912419 | 104790 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 439 | 6 | 0 | 3 | 6.3 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(I)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL272912 | 104790 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 439 | 6 | 0 | 3 | 6.3 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(I)cc2C)c1C | 10.1021/jm070578k | |||
| 21912223 | 104361 | 1 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 328 | 6 | 1 | 4 | 5.3 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1N | 10.1021/jm070578k | |||
| CHEMBL270780 | 104361 | 1 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 328 | 6 | 1 | 4 | 5.3 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1N | 10.1021/jm070578k | |||
| 21912419 | 104790 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 439 | 6 | 0 | 3 | 6.3 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(I)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL272912 | 104790 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 439 | 6 | 0 | 3 | 6.3 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(I)cc2C)c1C | 10.1021/jm070578k | |||
| 44444317 | 100836 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 363 | 5 | 0 | 4 | 5.7 | CCC(CC)n1cc2c3c(nc(C)cc31)N(c1ccc(OC)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL248962 | 100836 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 363 | 5 | 0 | 4 | 5.7 | CCC(CC)n1cc2c3c(nc(C)cc31)N(c1ccc(OC)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| 44444316 | 168453 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 358 | 4 | 0 | 4 | 5.6 | CCC(CC)n1cc2c3c(nc(C)cc31)N(c1ccc(C#N)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL413134 | 168453 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 358 | 4 | 0 | 4 | 5.6 | CCC(CC)n1cc2c3c(nc(C)cc31)N(c1ccc(C#N)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| 42618213 | 190872 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 409 | 8 | 0 | 7 | 4.5 | CCCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL482543 | 190872 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 409 | 8 | 0 | 7 | 4.5 | CCCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 58801644 | 84335 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 493 | 11 | 0 | 7 | 5.4 | CCc1nn2c(-c3c(COC)cc(OC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087568 | 84335 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 493 | 11 | 0 | 7 | 5.4 | CCc1nn2c(-c3c(COC)cc(OC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| 58801647 | 84342 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 479 | 10 | 0 | 7 | 5.1 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(C)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| CHEMBL2087575 | 84342 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 479 | 10 | 0 | 7 | 5.1 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(C)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| 45268739 | 202734 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 365 | 4 | 1 | 5 | 4.3 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2cc3c(cc2Cl)COC3)c1=O | 10.1021/jm900302q | |||
| CHEMBL559566 | 202734 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 365 | 4 | 1 | 5 | 4.3 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2cc3c(cc2Cl)COC3)c1=O | 10.1021/jm900302q | |||
| 155543377 | 180082 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 563 | 8 | 2 | 6 | 6.7 | COc1cc(Br)cc(C)c1Nc1nc2cccc(N(c3cccc(C(C)(C)C(N)=O)c3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4526083 | 180082 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 563 | 8 | 2 | 6 | 6.7 | COc1cc(Br)cc(C)c1Nc1nc2cccc(N(c3cccc(C(C)(C)C(N)=O)c3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| 155568703 | 182892 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 521 | 7 | 2 | 6 | 6.0 | COc1cc(Br)cc(C)c1Nc1nc2cccc(N(c3cccc(C(N)=O)c3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4591720 | 182892 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 521 | 7 | 2 | 6 | 6.0 | COc1cc(Br)cc(C)c1Nc1nc2cccc(N(c3cccc(C(N)=O)c3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| 11639510 | 67423 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 380 | 6 | 0 | 5 | 4.5 | CCCN(CCC)c1nc2c(c(-c3c(C)cc(C)cc3C)cn2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| CHEMBL1760253 | 67423 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 380 | 6 | 0 | 5 | 4.5 | CCCN(CCC)c1nc2c(c(-c3c(C)cc(C)cc3C)cn2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| CHEMBL5280146 | 200832 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 382 | 4 | 0 | 5 | 5.5 | CCN(CC)c1cc(C)nn2c(-c3sc4ccc(F)cc4c3C)c(C)nc12 | 10.1016/j.ejmech.2021.113867 | |||
| 11282792 | 196274 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 469 | 4 | 1 | 7 | 3.6 | Cc1cc(-n2ccc(N3CCNC3=O)n2)c2c(n1)N(c1ccc(C#N)cc1OC(F)(F)F)CC2 | 10.1021/jm800744m | |||
| CHEMBL513937 | 196274 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 469 | 4 | 1 | 7 | 3.6 | Cc1cc(-n2ccc(N3CCNC3=O)n2)c2c(n1)N(c1ccc(C#N)cc1OC(F)(F)F)CC2 | 10.1021/jm800744m | |||
| 11338604 | 196466 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 402 | 4 | 1 | 7 | 3.1 | COc1ccc(N2CCc3c(-n4ccc(-n5cc[nH]c5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| CHEMBL515363 | 196466 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 402 | 4 | 1 | 7 | 3.1 | COc1ccc(N2CCc3c(-n4ccc(-n5cc[nH]c5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| 45272175 | 201869 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 380 | 6 | 1 | 6 | 4.0 | C=Cc1cn([C@H](C)C2CC2)c(=O)c(Nc2ccc(OC)nc2C(F)(F)F)n1 | 10.1021/jm900301y | |||
| CHEMBL549747 | 201869 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 380 | 6 | 1 | 6 | 4.0 | C=Cc1cn([C@H](C)C2CC2)c(=O)c(Nc2ccc(OC)nc2C(F)(F)F)n1 | 10.1021/jm900301y | |||
| 10474043 | 71351 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 365 | 7 | 0 | 4 | 4.9 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL181593 | 71351 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 365 | 7 | 0 | 4 | 4.9 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 57393712 | 76759 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 337 | 5 | 0 | 4 | 5.2 | CCC(CC)c1nc(C)n2nc(-c3ccc(OC)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939579 | 76759 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 337 | 5 | 0 | 4 | 5.2 | CCC(CC)c1nc(C)n2nc(-c3ccc(OC)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | |||
| 9865886 | 182645 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 403 | 4 | 0 | 6 | 3.7 | COc1ccc(N2CCc3c(-n4ccc(N5CCCC5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| CHEMBL458599 | 182645 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 403 | 4 | 0 | 6 | 3.7 | COc1ccc(N2CCc3c(-n4ccc(N5CCCC5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| 11189676 | 182368 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 432 | 5 | 1 | 6 | 3.9 | Cc1cc(-n2ccc(N3CCNC3=O)n2)c2c(n1)N(c1ccc(OC(C)C)cc1C)CC2 | 10.1021/jm800744m | |||
| CHEMBL457975 | 182368 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 432 | 5 | 1 | 6 | 3.9 | Cc1cc(-n2ccc(N3CCNC3=O)n2)c2c(n1)N(c1ccc(OC(C)C)cc1C)CC2 | 10.1021/jm800744m | |||
| 44444331 | 101149 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 455 | 4 | 0 | 3 | 7.4 | CCC(CC)n1cc2c3c(nc(C)cc31)N(c1ccc(C(F)(F)F)cc1C(F)(F)F)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL250803 | 101149 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 455 | 4 | 0 | 3 | 7.4 | CCC(CC)n1cc2c3c(nc(C)cc31)N(c1ccc(C(F)(F)F)cc1C(F)(F)F)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| 44444312 | 174554 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 391 | 7 | 0 | 4 | 6.5 | CCCC(CCC)n1cc2c3c(nc(C)cc31)N(c1ccc(OC)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL430396 | 174554 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 391 | 7 | 0 | 4 | 6.5 | CCCC(CCC)n1cc2c3c(nc(C)cc31)N(c1ccc(OC)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| 44589224 | 182806 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 398 | 4 | 0 | 7 | 4.5 | CCc1cc(C#N)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| CHEMBL459007 | 182806 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 398 | 4 | 0 | 7 | 4.5 | CCc1cc(C#N)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| 71459110 | 89389 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 456 | 8 | 0 | 9 | 4.4 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(C#N)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| CHEMBL2179192 | 89389 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 456 | 8 | 0 | 9 | 4.4 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(C#N)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| 53357535 | 137385 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 429 | 5 | 1 | 4 | 4.9 | COc1cc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | |||
| CHEMBL3681390 | 137385 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 429 | 5 | 1 | 4 | 4.9 | COc1cc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | |||
| 11166718 | 74039 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 444 | 3 | 1 | 5 | 4.2 | Cc1cc(N2CCOCC2)c2c(n1)N(c1ccc(C(C)C)cc1Br)CC(=O)N2 | 10.1021/jm049737f | |||
| CHEMBL188112 | 74039 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 444 | 3 | 1 | 5 | 4.2 | Cc1cc(N2CCOCC2)c2c(n1)N(c1ccc(C(C)C)cc1Br)CC(=O)N2 | 10.1021/jm049737f | |||
| 44589205 | 182737 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 425 | 4 | 0 | 8 | 4.6 | Cc1cc(-n2cccn2)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| CHEMBL458826 | 182737 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 425 | 4 | 0 | 8 | 4.6 | Cc1cc(-n2cccn2)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| 127030924 | 146146 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 397 | 6 | 1 | 6 | 5.0 | CCN(CC)c1ccc(C#N)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3793070 | 146146 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 397 | 6 | 1 | 6 | 5.0 | CCN(CC)c1ccc(C#N)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 127030927 | 146272 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 402 | 7 | 1 | 6 | 5.1 | CCN(CC)c1ccc(OC)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3794479 | 146272 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 402 | 7 | 1 | 6 | 5.1 | CCN(CC)c1ccc(OC)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 58896493 | 146284 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 416 | 6 | 1 | 5 | 5.2 | CCN(CC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3793322 | 146284 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 416 | 6 | 1 | 5 | 5.2 | CCN(CC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3794596 | 146284 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 416 | 6 | 1 | 5 | 5.2 | CCN(CC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 56673725 | 72083 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 403 | 9 | 1 | 7 | 4.8 | CCCN(CCC)c1c(OC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828895 | 72083 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 403 | 9 | 1 | 7 | 4.8 | CCCN(CCC)c1c(OC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 21984718 | 84321 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 403 | 8 | 0 | 4 | 5.8 | CCc1nn2c(-c3c(C)cc(OC)cc3C)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087554 | 84321 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 403 | 8 | 0 | 4 | 5.8 | CCc1nn2c(-c3c(C)cc(OC)cc3C)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | |||
| 46891386 | 13183 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 404 | 6 | 1 | 6 | 4.6 | Cc1nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c(=O)n([C@H](C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082355 | 13183 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 404 | 6 | 1 | 6 | 4.6 | Cc1nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c(=O)n([C@H](C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 46891191 | 13199 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 353 | 6 | 1 | 7 | 3.2 | CCC(C1CC1)n1nc(C)nc(Nc2cc(OC)c(C#N)cc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082402 | 13199 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 353 | 6 | 1 | 7 | 3.2 | CCC(C1CC1)n1nc(C)nc(Nc2cc(OC)c(C#N)cc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 155561680 | 182468 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 434 | 6 | 1 | 5 | 6.8 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(c3ccccc3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4581950 | 182468 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 434 | 6 | 1 | 5 | 6.8 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(c3ccccc3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| 53357921 | 137390 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 427 | 5 | 1 | 3 | 5.4 | CCc1cc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | |||
| CHEMBL3681395 | 137390 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 427 | 5 | 1 | 3 | 5.4 | CCc1cc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | |||
| 57398972 | 76783 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 339 | 3 | 0 | 5 | 3.8 | COc1cc(C)c(-c2nn3c(C)cc(C(C)C)c3c(=O)n2C)c(C)c1 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939602 | 76783 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 339 | 3 | 0 | 5 | 3.8 | COc1cc(C)c(-c2nn3c(C)cc(C(C)C)c3c(=O)n2C)c(C)c1 | 10.1016/j.bmc.2011.11.015 | |||
| 24758073 | 76754 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 364 | 7 | 0 | 3 | 6.5 | CCOc1ccc(-c2nn3c(C)cc(C(CC)CC)c3cc2C)c(CC)c1 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939574 | 76754 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 364 | 7 | 0 | 3 | 6.5 | CCOc1ccc(-c2nn3c(C)cc(C(CC)CC)c3cc2C)c(CC)c1 | 10.1016/j.bmc.2011.11.015 | |||
| 42618204 | 186059 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 429 | 10 | 0 | 9 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3cc(OC)c(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL473077 | 186059 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 429 | 10 | 0 | 9 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3cc(OC)c(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 42618214 | 199307 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 353 | 5 | 0 | 7 | 3.0 | CCN(CC)c1nc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL520955 | 199307 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 353 | 5 | 0 | 7 | 3.0 | CCN(CC)c1nc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 58223500 | 134629 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 489 | 10 | 0 | 9 | 5.0 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCCOCC1 | nan | |||
| CHEMBL3664564 | 134629 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 489 | 10 | 0 | 9 | 5.0 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCCOCC1 | nan | |||
| 60155793 | 84332 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 479 | 10 | 0 | 7 | 5.2 | CCc1nn2c(-c3cc(OC)c(OC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087565 | 84332 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 479 | 10 | 0 | 7 | 5.2 | CCc1nn2c(-c3cc(OC)c(OC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| 57785779 | 171710 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 459 | 4 | 0 | 5 | 6.7 | CCC(c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl)n1ccnc1 | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4224722 | 171710 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 459 | 4 | 0 | 5 | 6.7 | CCC(c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl)n1ccnc1 | 10.1016/j.bmc.2018.01.020 | |||
| 57393715 | 76779 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 339 | 3 | 0 | 6 | 2.9 | Cc1nc(N(C)C)ccc1-c1nn2c(C)cc(C(C)C)c2c(=O)n1C | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939599 | 76779 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 339 | 3 | 0 | 6 | 2.9 | Cc1nc(N(C)C)ccc1-c1nn2c(C)cc(C(C)C)c2c(=O)n1C | 10.1016/j.bmc.2011.11.015 | |||
| 53358605 | 137372 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 5 | 1 | 4 | 5.2 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@@H](Cn2nc(-c3ccccc3)cc2C)CC1 | nan | |||
| CHEMBL3681377 | 137372 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 5 | 1 | 4 | 5.2 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@@H](Cn2nc(-c3ccccc3)cc2C)CC1 | nan | |||
| 58223436 | 134617 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 445 | 9 | 0 | 9 | 3.8 | CCCN(CC1CCOC1)c1c(OC)nn2c(-c3cnc(N(C)C)cc3OC)csc12 | nan | |||
| CHEMBL3664552 | 134617 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 445 | 9 | 0 | 9 | 3.8 | CCCN(CC1CCOC1)c1c(OC)nn2c(-c3cnc(N(C)C)cc3OC)csc12 | nan | |||
| 71451515 | 88284 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 405 | 7 | 0 | 6 | 5.0 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(C#N)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160158 | 88284 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 405 | 7 | 0 | 6 | 5.0 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(C#N)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 53357793 | 137387 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 399 | 4 | 1 | 3 | 4.9 | Cc1cnn(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1 | nan | |||
| CHEMBL3681392 | 137387 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 399 | 4 | 1 | 3 | 4.9 | Cc1cnn(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1 | nan | |||
| 42618209 | 186588 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 427 | 9 | 0 | 9 | 2.6 | COCCN(CCOC)c1nc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL474492 | 186588 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 427 | 9 | 0 | 9 | 2.6 | COCCN(CCOC)c1nc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 53358858 | 137367 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 389 | 6 | 3 | 4 | 4.0 | CCc1[nH]nc(NC[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)c1C | nan | |||
| CHEMBL3681372 | 137367 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 389 | 6 | 3 | 4 | 4.0 | CCc1[nH]nc(NC[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)c1C | nan | |||
| 21912226 | 104511 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 329 | 6 | 1 | 4 | 5.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(O)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL271557 | 104511 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 329 | 6 | 1 | 4 | 5.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(O)cc2C)c1C | 10.1021/jm070578k | |||
| 71453735 | 89386 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 475 | 9 | 0 | 9 | 4.6 | COCc1cc(OC)c(-c2csc3c(N(C(C)C)C4CCOCC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| CHEMBL2179189 | 89386 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 475 | 9 | 0 | 9 | 4.6 | COCc1cc(OC)c(-c2csc3c(N(C(C)C)C4CCOCC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| 70696576 | 82358 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 438 | 11 | 0 | 6 | 6.1 | CCCN(CCC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| CHEMBL2046526 | 82358 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 438 | 11 | 0 | 6 | 6.1 | CCCN(CCC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| 70696576 | 82358 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 438 | 11 | 0 | 6 | 6.1 | CCCN(CCC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2046526 | 82358 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 438 | 11 | 0 | 6 | 6.1 | CCCN(CCC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | |||
| 58896474 | 146222 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 400 | 8 | 1 | 5 | 5.9 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3793985 | 146222 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 400 | 8 | 1 | 5 | 5.9 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 127031514 | 146230 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 425 | 8 | 1 | 6 | 5.8 | CCCN(CCC)c1ccc(C#N)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3794030 | 146230 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 425 | 8 | 1 | 6 | 5.8 | CCCN(CCC)c1ccc(C#N)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 58896536 | 146285 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 472 | 10 | 1 | 5 | 6.8 | CCCCN(CCCC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3792935 | 146285 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 472 | 10 | 1 | 5 | 6.8 | CCCCN(CCCC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3794597 | 146285 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 472 | 10 | 1 | 5 | 6.8 | CCCCN(CCCC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 56677028 | 72073 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 359 | 7 | 2 | 6 | 4.7 | CCC(CC)Nc1cc(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828886 | 72073 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 359 | 7 | 2 | 6 | 4.7 | CCC(CC)Nc1cc(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 71580312 | 95212 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 475 | 9 | 1 | 8 | 3.4 | COc1nc(Cl)nc(C)c1Nc1nc(Br)cn([C@@H](COCCF)C2CC2)c1=O | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL2349563 | 95212 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 475 | 9 | 1 | 8 | 3.4 | COc1nc(Cl)nc(C)c1Nc1nc(Br)cn([C@@H](COCCF)C2CC2)c1=O | 10.1016/j.bmcl.2013.02.009 | |||
| 44596811 | 205022 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 352 | 6 | 1 | 7 | 2.9 | COC[C@@H](C)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1021/jm900716v | |||
| CHEMBL575510 | 205022 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 352 | 6 | 1 | 7 | 2.9 | COC[C@@H](C)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1021/jm900716v | |||
| 46891033 | 14173 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.0 | Cc1nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1086508 | 14173 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.0 | Cc1nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 58280027 | 146782 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 435 | 8 | 2 | 8 | 3.4 | CCNC(=O)OC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3800035 | 146782 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 435 | 8 | 2 | 8 | 3.4 | CCNC(=O)OC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1016/j.bmcl.2016.03.067 | |||
| 10179550 | 71653 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 406 | 5 | 0 | 4 | 5.3 | CCc1nc2c(n1C(CC)C1CC1)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL182169 | 71653 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 406 | 5 | 0 | 4 | 5.3 | CCc1nc2c(n1C(CC)C1CC1)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 136042278 | 76761 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 4.6 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)[nH]c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939581 | 76761 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 359 | 5 | 1 | 4 | 4.6 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)[nH]c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 42618218 | 190912 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 340 | 5 | 0 | 7 | 3.0 | CCN(CC)c1nc(C)nc2c(-c3cnc(OC)cc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL482751 | 190912 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 340 | 5 | 0 | 7 | 3.0 | CCN(CC)c1nc(C)nc2c(-c3cnc(OC)cc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 42618211 | 186081 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 395 | 7 | 0 | 7 | 4.1 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL473275 | 186081 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 395 | 7 | 0 | 7 | 4.1 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 58896427 | 146281 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 350 | 7 | 1 | 4 | 5.6 | CCCN(CCC)c1cccc2nc(Nc3c(C)cccc3C)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3793329 | 146281 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 350 | 7 | 1 | 4 | 5.6 | CCCN(CCC)c1cccc2nc(Nc3c(C)cccc3C)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3794593 | 146281 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 350 | 7 | 1 | 4 | 5.6 | CCCN(CCC)c1cccc2nc(Nc3c(C)cccc3C)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 46881864 | 14782 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 360 | 5 | 1 | 8 | 2.6 | COc1nc(C)nc(C#N)c1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1090738 | 14782 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 360 | 5 | 1 | 8 | 2.6 | COc1nc(C)nc(C#N)c1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| 137646761 | 164619 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 479 | 7 | 2 | 6 | 4.4 | CCN(CC(N)=O)c1ccc(Br)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4083664 | 164619 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 479 | 7 | 2 | 6 | 4.4 | CCN(CC(N)=O)c1ccc(Br)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 54586828 | 67425 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 404 | 6 | 0 | 5 | 4.5 | Cc1cc(C)c(-c2cn(C)c3nc(N(CC4CC4)CC4CC4)n(C)c(=O)c23)c(C)c1 | 10.1016/j.bmcl.2011.02.086 | |||
| CHEMBL1760255 | 67425 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 404 | 6 | 0 | 5 | 4.5 | Cc1cc(C)c(-c2cn(C)c3nc(N(CC4CC4)CC4CC4)n(C)c(=O)c23)c(C)c1 | 10.1016/j.bmcl.2011.02.086 | |||
| 21912226 | 104511 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 329 | 6 | 1 | 4 | 5.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(O)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL271557 | 104511 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 329 | 6 | 1 | 4 | 5.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(O)cc2C)c1C | 10.1021/jm070578k | |||
| 53357269 | 137378 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 423 | 5 | 1 | 5 | 4.6 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2nc(-c3cccnc3)cc2C)CC1 | nan | |||
| CHEMBL3681383 | 137378 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 423 | 5 | 1 | 5 | 4.6 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2nc(-c3cccnc3)cc2C)CC1 | nan | |||
| 70686533 | 83393 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 412 | 8 | 0 | 5 | 5.4 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(F)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| CHEMBL2063381 | 83393 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 412 | 8 | 0 | 5 | 5.4 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(F)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| 70686533 | 83393 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 412 | 8 | 0 | 5 | 5.4 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(F)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2063381 | 83393 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 412 | 8 | 0 | 5 | 5.4 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(F)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 71453344 | 88294 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 444 | 9 | 0 | 6 | 5.6 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(Cl)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160169 | 88294 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 444 | 9 | 0 | 6 | 5.6 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(Cl)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 11983528 | 181684 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 418 | 4 | 1 | 6 | 3.5 | COc1ccc(N2CCc3c(-n4ccc(N5CCCNC5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| CHEMBL456448 | 181684 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 418 | 4 | 1 | 6 | 3.5 | COc1ccc(N2CCc3c(-n4ccc(N5CCCNC5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| 44589351 | 184607 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 421 | 3 | 0 | 7 | 4.0 | N#Cc1ccc(N2CCc3c(-n4ccc(-n5cccn5)n4)ccnc32)c(C(F)(F)F)c1 | 10.1021/jm800743q | |||
| CHEMBL464390 | 184607 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 421 | 3 | 0 | 7 | 4.0 | N#Cc1ccc(N2CCc3c(-n4ccc(-n5cccn5)n4)ccnc32)c(C(F)(F)F)c1 | 10.1021/jm800743q | |||
| 71451920 | 89382 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 461 | 9 | 0 | 9 | 4.2 | CCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| CHEMBL2179185 | 89382 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 461 | 9 | 0 | 9 | 4.2 | CCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| 67380345 | 137376 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 4 | 1 | 3 | 5.0 | O=C(N[C@H]1CC[C@H](Cn2cc3c(n2)CCC3)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | |||
| CHEMBL3681381 | 137376 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 4 | 1 | 3 | 5.0 | O=C(N[C@H]1CC[C@H](Cn2cc3c(n2)CCC3)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | |||
| 21912127 | 104435 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1 | 10.1021/jm070578k | |||
| CHEMBL271117 | 104435 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1 | 10.1021/jm070578k | |||
| 136042277 | 76760 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)[nH]c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939580 | 76760 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 339 | 5 | 1 | 4 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)[nH]c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 11210737 | 146232 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 364 | 7 | 1 | 4 | 5.9 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3794051 | 146232 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 364 | 7 | 1 | 4 | 5.9 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 54754517 | 72270 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 417 | 10 | 0 | 7 | 4.8 | CCCN(CCC)c1cc(N(COC)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830514 | 72270 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 417 | 10 | 0 | 7 | 4.8 | CCCN(CCC)c1cc(N(COC)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 10200135 | 84322 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 385 | 8 | 0 | 4 | 5.9 | CCCN(CCC)c1c(CC)nn2c(-c3ccc(OC)cc3Cl)cccc12 | 10.1021/jm300259r | |||
| CHEMBL2087555 | 84322 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 385 | 8 | 0 | 4 | 5.9 | CCCN(CCC)c1c(CC)nn2c(-c3ccc(OC)cc3Cl)cccc12 | 10.1021/jm300259r | |||
| 22177744 | 71530 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 452 | 6 | 1 | 5 | 6.3 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC(F)(F)F)cc4Cl)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819081 | 71530 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 452 | 6 | 1 | 5 | 6.3 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC(F)(F)F)cc4Cl)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 46890982 | 13296 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 368 | 5 | 1 | 6 | 4.0 | COc1cc(Cl)c(Nc2nc(C)nn(C(C)C3CC3)c2=O)c(Cl)c1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082792 | 13296 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 368 | 5 | 1 | 6 | 4.0 | COc1cc(Cl)c(Nc2nc(C)nn(C(C)C3CC3)c2=O)c(Cl)c1 | 10.1016/j.bmcl.2010.04.121 | |||
| 46891494 | 13411 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 399 | 7 | 1 | 8 | 2.7 | COC[C@H](C1CC1)n1nc(C)nc(Nc2ccc(OC)nc2C(F)(F)F)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1083325 | 13411 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 399 | 7 | 1 | 8 | 2.7 | COC[C@H](C1CC1)n1nc(C)nc(Nc2ccc(OC)nc2C(F)(F)F)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 44191109 | 202308 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 363 | 6 | 1 | 6 | 3.9 | COc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1OC | 10.1021/jm900302q | |||
| CHEMBL554086 | 202308 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 363 | 6 | 1 | 6 | 3.9 | COc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1OC | 10.1021/jm900302q | |||
| 21912175 | 162498 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 358 | 7 | 0 | 5 | 5.6 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1[N+](=O)[O-] | 10.1021/jm070578k | |||
| CHEMBL405347 | 162498 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 358 | 7 | 0 | 5 | 5.6 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1[N+](=O)[O-] | 10.1021/jm070578k | |||
| 58012333 | 166260 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 405 | 6 | 1 | 4 | 6.8 | CCC(CC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4101653 | 166260 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 405 | 6 | 1 | 4 | 6.8 | CCC(CC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 21912175 | 162498 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 358 | 7 | 0 | 5 | 5.6 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1[N+](=O)[O-] | 10.1021/jm070578k | |||
| CHEMBL405347 | 162498 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 358 | 7 | 0 | 5 | 5.6 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1[N+](=O)[O-] | 10.1021/jm070578k | |||
| 42618195 | 191065 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 413 | 9 | 0 | 8 | 3.1 | COCCN(CCOC)c1nc(C)nc2c(-c3cc(C)c(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL483993 | 191065 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 413 | 9 | 0 | 8 | 3.1 | COCCN(CCOC)c1nc(C)nc2c(-c3cc(C)c(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 3495 | 7958 | 28 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2007.06.077 | |||
| 5311055 | 7958 | 28 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL9946 | 7958 | 28 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2007.06.077 | |||
| 10277733 | 69916 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 484 | 6 | 0 | 4 | 7.6 | CCCC(CCC)n1cc2c3c(nc(C)nc31)N(c1ccc(C(F)(F)F)cc1C(F)(F)F)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL178949 | 69916 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 484 | 6 | 0 | 4 | 7.6 | CCCC(CCC)n1cc2c3c(nc(C)nc31)N(c1ccc(C(F)(F)F)cc1C(F)(F)F)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| 45268771 | 203412 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 354 | 5 | 1 | 6 | 3.4 | COc1ccc(Nc2nccn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1021/jm900301y | |||
| CHEMBL564291 | 203412 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 354 | 5 | 1 | 6 | 3.4 | COc1ccc(Nc2nccn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1021/jm900301y | |||
| 21912127 | 104435 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1 | 10.1021/jm070578k | |||
| CHEMBL271117 | 104435 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 313 | 6 | 0 | 3 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1 | 10.1021/jm070578k | |||
| 137642541 | 165075 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 493 | 7 | 2 | 6 | 4.6 | CCN(CC(=O)NC)c1ccc(Br)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4089028 | 165075 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 493 | 7 | 2 | 6 | 4.6 | CCN(CC(=O)NC)c1ccc(Br)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 11164902 | 73076 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N(C)C)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL184850 | 73076 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N(C)C)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 70692630 | 82673 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 376 | 7 | 1 | 4 | 6.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)nc12 | 10.1016/j.ejmech.2021.114085 | |||
| CHEMBL2049188 | 82673 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 376 | 7 | 1 | 4 | 6.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)nc12 | 10.1016/j.ejmech.2021.114085 | |||
| 70692630 | 82673 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 376 | 7 | 1 | 4 | 6.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)nc12 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2049188 | 82673 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 376 | 7 | 1 | 4 | 6.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)nc12 | 10.1016/j.bmcl.2012.05.066 | |||
| 71455053 | 88299 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 482 | 12 | 0 | 7 | 5.5 | COCCN(CC(C)C)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160173 | 88299 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 482 | 12 | 0 | 7 | 5.5 | COCCN(CC(C)C)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 70681900 | 82361 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 492 | 10 | 0 | 7 | 5.9 | COCc1cc(OC)c(Oc2nc3cccc(N(CC4CC4)C4CCOCC4)c3cc2C)c(OC)c1 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2046529 | 82361 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 492 | 10 | 0 | 7 | 5.9 | COCc1cc(OC)c(Oc2nc3cccc(N(CC4CC4)C4CCOCC4)c3cc2C)c(OC)c1 | 10.1016/j.bmcl.2012.05.066 | |||
| 44444337 | 100908 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 379 | 6 | 0 | 5 | 5.0 | CCC(COC)n1cc2c3c(nc(C)cc31)N(c1ccc(OC)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL249333 | 100908 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 379 | 6 | 0 | 5 | 5.0 | CCC(COC)n1cc2c3c(nc(C)cc31)N(c1ccc(OC)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| 44589317 | 184462 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 426 | 3 | 1 | 6 | 4.1 | Cc1cc(-n2ccc(-n3cc[nH]c3=O)n2)c2c(n1)N(c1ccc(Cl)cc1Cl)CC2 | 10.1021/jm800744m | |||
| CHEMBL464184 | 184462 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 426 | 3 | 1 | 6 | 4.1 | Cc1cc(-n2ccc(-n3cc[nH]c3=O)n2)c2c(n1)N(c1ccc(Cl)cc1Cl)CC2 | 10.1021/jm800744m | |||
| 44589237 | 183790 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 454 | 4 | 0 | 8 | 4.9 | N#Cc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(OC(F)(F)F)c1 | 10.1021/jm800743q | |||
| CHEMBL462788 | 183790 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 454 | 4 | 0 | 8 | 4.9 | N#Cc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(OC(F)(F)F)c1 | 10.1021/jm800743q | |||
| 56670270 | 72271 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 374 | 7 | 2 | 7 | 4.4 | CCC(CC)Nc1c(C)c(Nc2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830515 | 72271 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 374 | 7 | 2 | 7 | 4.4 | CCC(CC)Nc1c(C)c(Nc2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 21984613 | 84318 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 389 | 8 | 0 | 4 | 5.5 | CCc1nn2c(-c3ccc(OC)cc3C)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087551 | 84318 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 389 | 8 | 0 | 4 | 5.5 | CCc1nn2c(-c3ccc(OC)cc3C)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | |||
| 15485774 | 203154 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 365 | 7 | 1 | 6 | 3.4 | COCC(COC)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL562619 | 203154 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 365 | 7 | 1 | 6 | 3.4 | COCC(COC)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| 18392782 | 104744 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 325 | 5 | 0 | 3 | 6.1 | C/C=C(\CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL272674 | 104744 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 325 | 5 | 0 | 3 | 6.1 | C/C=C(\CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| 44347046 | 121323 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 377 | 6 | 0 | 3 | 6.5 | CCCCN(CC)c1cc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL333713 | 121323 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 377 | 6 | 0 | 3 | 6.5 | CCCCN(CC)c1cc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2004.05.056 | |||
| 18392782 | 104744 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 325 | 5 | 0 | 3 | 6.1 | C/C=C(\CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL272674 | 104744 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 325 | 5 | 0 | 3 | 6.1 | C/C=C(\CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL5269179 | 200373 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 381 | 4 | 0 | 4 | 6.6 | CCC(CC)c1cc(C)nn2c(-c3sc4ccc(F)cc4c3C)c(C)nc12 | 10.1016/j.ejmech.2021.113867 | |||
| 16126888 | 76749 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 336 | 5 | 0 | 3 | 5.8 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939569 | 76749 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 336 | 5 | 0 | 3 | 5.8 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | |||
| 24758071 | 76753 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 334 | 4 | 0 | 2 | 6.4 | CCC(CC)c1cc(C)n2nc(-c3cc(C)c(C)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939573 | 76753 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 334 | 4 | 0 | 2 | 6.4 | CCC(CC)c1cc(C)n2nc(-c3cc(C)c(C)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | |||
| 58896526 | 183407 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 468 | 5 | 1 | 5 | 6.6 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(C(C)=O)c3ccc(Cl)cc3)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4592625 | 183407 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 468 | 5 | 1 | 5 | 6.6 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(C(C)=O)c3ccc(Cl)cc3)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4597886 | 183407 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 468 | 5 | 1 | 5 | 6.6 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(C(C)=O)c3ccc(Cl)cc3)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| 53358603 | 137370 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 388 | 6 | 1 | 4 | 4.4 | CCc1cc(CC)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)n1 | nan | |||
| CHEMBL3681375 | 137370 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 388 | 6 | 1 | 4 | 4.4 | CCc1cc(CC)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)n1 | nan | |||
| 11164902 | 73076 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL184850 | 73076 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 54580962 | 67429 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 366 | 6 | 0 | 5 | 4.2 | CCCN(CCC)c1nc2c(c(-c3ccc(C)cc3C)cn2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| CHEMBL1760259 | 67429 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 366 | 6 | 0 | 5 | 4.2 | CCCN(CCC)c1nc2c(c(-c3ccc(C)cc3C)cn2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| 44392573 | 71064 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 475 | 10 | 0 | 6 | 5.8 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(OC)cc1Cc1cccnc1 | 10.1021/jm049787k | |||
| CHEMBL181007 | 71064 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 475 | 10 | 0 | 6 | 5.8 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(OC)cc1Cc1cccnc1 | 10.1021/jm049787k | |||
| 44589206 | 182894 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 377 | 3 | 0 | 6 | 4.5 | Cc1cc(F)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| CHEMBL459174 | 182894 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 377 | 3 | 0 | 6 | 4.5 | Cc1cc(F)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| 53358855 | 137373 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 413 | 4 | 1 | 3 | 5.2 | Cc1cn(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)nc1C | nan | |||
| CHEMBL3681378 | 137373 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 413 | 4 | 1 | 3 | 5.2 | Cc1cn(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)nc1C | nan | |||
| 145958142 | 168837 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 383 | 6 | 1 | 6 | 4.8 | CCCCN(CC)c1nc(C)nc2c1sc(=N)n2-c1c(C)cc(C)cc1C | 10.1016/j.ejmech.2017.07.016 | |||
| CHEMBL4160471 | 168837 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 383 | 6 | 1 | 6 | 4.8 | CCCCN(CC)c1nc(C)nc2c1sc(=N)n2-c1c(C)cc(C)cc1C | 10.1016/j.ejmech.2017.07.016 | |||
| 46881695 | 13695 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 350 | 6 | 1 | 7 | 3.0 | COc1ccc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(OC)n1 | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1084414 | 13695 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 350 | 6 | 1 | 7 | 3.0 | COc1ccc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(OC)n1 | 10.1016/j.bmcl.2010.01.129 | |||
| 3520 | 10041 | 54 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmc.2016.11.011 | |||
| 9821250 | 10041 | 54 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL309138 | 10041 | 54 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmc.2016.11.011 | |||
| 42618180 | 191136 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 367 | 5 | 1 | 7 | 3.7 | COc1cc(C)c(-c2c(C)nn3c(NC4CCC4)nc(C)nc23)c(OC)c1 | 10.1021/jm9000242 | |||
| CHEMBL484419 | 191136 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 367 | 5 | 1 | 7 | 3.7 | COc1cc(C)c(-c2c(C)nn3c(NC4CCC4)nc(C)nc23)c(OC)c1 | 10.1021/jm9000242 | |||
| 42618232 | 190993 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 340 | 5 | 0 | 7 | 3.0 | CCCN(C)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL483349 | 190993 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 340 | 5 | 0 | 7 | 3.0 | CCCN(C)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 70909803 | 146231 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 468 | 8 | 1 | 5 | 7.2 | CCCN(CCC)c1c(Cl)cc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3794050 | 146231 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 468 | 8 | 1 | 5 | 7.2 | CCCN(CCC)c1c(Cl)cc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 10110271 | 71513 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 379 | 6 | 2 | 6 | 4.6 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CCN2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819063 | 71513 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 379 | 6 | 2 | 6 | 4.6 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CCN2 | 10.1016/j.bmc.2011.07.055 | |||
| 53358857 | 137375 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 4 | 1 | 3 | 5.0 | O=C(N[C@H]1CC[C@H](Cn2ncc3c2CCC3)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | |||
| CHEMBL3681380 | 137375 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 4 | 1 | 3 | 5.0 | O=C(N[C@H]1CC[C@H](Cn2ncc3c2CCC3)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | |||
| 24768346 | 92327 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 381 | 7 | 1 | 6 | 4.5 | CCCCN(CC)c1nc(C)nc2c1NCCN2c1ccc(C(C)=O)cc1C | 10.1021/jm0611410 | |||
| CHEMBL227834 | 92327 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 381 | 7 | 1 | 6 | 4.5 | CCCCN(CC)c1nc(C)nc2c1NCCN2c1ccc(C(C)=O)cc1C | 10.1021/jm0611410 | |||
| 11188421 | 70663 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 388 | 7 | 0 | 4 | 5.4 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(Cl)cc1 | 10.1021/jm049787k | |||
| CHEMBL180449 | 70663 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 388 | 7 | 0 | 4 | 5.4 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(Cl)cc1 | 10.1021/jm049787k | |||
| 44589236 | 185136 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 405 | 5 | 0 | 8 | 4.1 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(OC)c1 | 10.1021/jm800743q | |||
| CHEMBL465216 | 185136 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 405 | 5 | 0 | 8 | 4.1 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(OC)c1 | 10.1021/jm800743q | |||
| 58223375 | 134645 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 475 | 11 | 0 | 9 | 4.6 | COCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCCC1 | nan | |||
| CHEMBL3664580 | 134645 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 475 | 11 | 0 | 9 | 4.6 | COCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCCC1 | nan | |||
| 44190912 | 203148 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 382 | 4 | 1 | 5 | 4.8 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(Cl)cc2C#N)c1=O | 10.1021/jm900302q | |||
| CHEMBL562550 | 203148 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 382 | 4 | 1 | 5 | 4.8 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(Cl)cc2C#N)c1=O | 10.1021/jm900302q | |||
| 44190824 | 203338 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 386 | 5 | 1 | 6 | 4.0 | COC[C@@H](C)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL563819 | 203338 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 386 | 5 | 1 | 6 | 4.0 | COC[C@@H](C)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 10108936 | 104789 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 356 | 7 | 1 | 4 | 4.8 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C(N)=O)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL272910 | 104789 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 356 | 7 | 1 | 4 | 4.8 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C(N)=O)cc2C)c1C | 10.1021/jm070578k | |||
| 137640280 | 163520 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 518 | 7 | 1 | 5 | 6.8 | CCN(CCC(F)(F)F)c1ccc(Br)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4070523 | 163520 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 518 | 7 | 1 | 5 | 6.8 | CCN(CCC(F)(F)F)c1ccc(Br)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 145968300 | 171760 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 376 | 5 | 1 | 4 | 5.8 | CCN(CC)c1cccc2nc(Nc3c(C)cc(Cl)cc3Cl)n(C)c12 | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4225516 | 171760 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 376 | 5 | 1 | 4 | 5.8 | CCN(CC)c1cccc2nc(Nc3c(C)cc(Cl)cc3Cl)n(C)c12 | 10.1016/j.bmc.2018.01.020 | |||
| 10224109 | 130811 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 7 | 0 | 4 | 6.1 | CCCCC(CC)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL363023 | 130811 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 7 | 0 | 4 | 6.1 | CCCCC(CC)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 11489867 | 19164 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 446 | 9 | 1 | 6 | 4.4 | COCCN(CCOC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL1185656 | 19164 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 446 | 9 | 1 | 6 | 4.4 | COCCN(CCOC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL425542 | 19164 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 446 | 9 | 1 | 6 | 4.4 | COCCN(CCOC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Cl | 10.1021/jm049737f | |||
| 10108936 | 104789 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 356 | 7 | 1 | 4 | 4.8 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C(N)=O)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL272910 | 104789 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 356 | 7 | 1 | 4 | 4.8 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C(N)=O)cc2C)c1C | 10.1021/jm070578k | |||
| 24758074 | 76755 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 350 | 4 | 0 | 4 | 5.6 | CCC(CC)c1cc(C)n2nc(-c3cc4c(cc3C)OCO4)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939575 | 76755 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 350 | 4 | 0 | 4 | 5.6 | CCC(CC)c1cc(C)n2nc(-c3cc4c(cc3C)OCO4)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | |||
| 177990 | 7214 | 23 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1016/j.ejmech.2017.07.016 | |||
| 3489 | 7214 | 23 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1016/j.ejmech.2017.07.016 | |||
| CHEMBL296641 | 7214 | 23 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1016/j.ejmech.2017.07.016 | |||
| 177990 | 7214 | 23 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1016/j.ejmech.2014.03.040 | |||
| 3489 | 7214 | 23 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1016/j.ejmech.2014.03.040 | |||
| CHEMBL296641 | 7214 | 23 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1016/j.ejmech.2014.03.040 | |||
| 44190560 | 202934 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.9 | CCc1cn([C@H](C)C2CC2)c(=O)c(Nc2ccc(OC)nc2C(F)(F)F)n1 | 10.1021/jm900301y | |||
| CHEMBL561226 | 202934 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 382 | 6 | 1 | 6 | 3.9 | CCc1cn([C@H](C)C2CC2)c(=O)c(Nc2ccc(OC)nc2C(F)(F)F)n1 | 10.1021/jm900301y | |||
| 44190244 | 203499 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 337 | 5 | 1 | 4 | 4.7 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2ccc(Cl)cc2)c1=O | 10.1021/jm900301y | |||
| CHEMBL564968 | 203499 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 337 | 5 | 1 | 4 | 4.7 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2ccc(Cl)cc2)c1=O | 10.1021/jm900301y | |||
| 21912198 | 104476 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 341 | 6 | 0 | 3 | 6.3 | CCC(CC)Oc1c(C)c(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL271332 | 104476 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 341 | 6 | 0 | 3 | 6.3 | CCC(CC)Oc1c(C)c(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| 53357142 | 137377 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 440 | 5 | 1 | 4 | 5.3 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@@H](Cn2nc(-c3ccc(F)cc3)cc2C)CC1 | nan | |||
| CHEMBL3681382 | 137377 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 440 | 5 | 1 | 4 | 5.3 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@@H](Cn2nc(-c3ccc(F)cc3)cc2C)CC1 | nan | |||
| 11773483 | 72347 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 382 | 7 | 0 | 7 | 4.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc([N+](=O)[O-])cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL183148 | 72347 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 382 | 7 | 0 | 7 | 4.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc([N+](=O)[O-])cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 11773483 | 72347 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 382 | 7 | 0 | 7 | 4.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc([N+](=O)[O-])cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL183148 | 72347 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 382 | 7 | 0 | 7 | 4.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc([N+](=O)[O-])cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 155567202 | 182744 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 492 | 8 | 1 | 6 | 7.6 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(c3ccc(OC(C)C)cc3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4588387 | 182744 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 492 | 8 | 1 | 6 | 7.6 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(c3ccc(OC(C)C)cc3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| 21912198 | 104476 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 341 | 6 | 0 | 3 | 6.3 | CCC(CC)Oc1c(C)c(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL271332 | 104476 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 341 | 6 | 0 | 3 | 6.3 | CCC(CC)Oc1c(C)c(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| 70682294 | 83392 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 394 | 8 | 0 | 5 | 5.2 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)ccc12 | 10.1016/j.bmcl.2012.07.047 | |||
| CHEMBL2063380 | 83392 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 394 | 8 | 0 | 5 | 5.2 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)ccc12 | 10.1016/j.bmcl.2012.07.047 | |||
| 70682294 | 83392 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 394 | 8 | 0 | 5 | 5.2 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)ccc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2063380 | 83392 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 394 | 8 | 0 | 5 | 5.2 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)ccc12 | 10.1016/j.bmc.2012.09.028 | |||
| 58223471 | 134647 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 463 | 12 | 0 | 9 | 4.3 | COCCN(CC(C)C)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| CHEMBL3664582 | 134647 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 463 | 12 | 0 | 9 | 4.3 | COCCN(CC(C)C)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| 71580311 | 95211 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 431 | 9 | 1 | 8 | 3.3 | COc1nc(Cl)nc(C)c1Nc1nc(Cl)cn([C@@H](COCCF)C2CC2)c1=O | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL2349562 | 95211 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 431 | 9 | 1 | 8 | 3.3 | COc1nc(Cl)nc(C)c1Nc1nc(Cl)cn([C@@H](COCCF)C2CC2)c1=O | 10.1016/j.bmcl.2013.02.009 | |||
| 46890978 | 13505 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 312 | 4 | 1 | 5 | 3.6 | Cc1cc(C)c(Nc2nc(C)nn(C(C)C3CC3)c2=O)c(C)c1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1083724 | 13505 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 312 | 4 | 1 | 5 | 3.6 | Cc1cc(C)c(Nc2nc(C)nn(C(C)C3CC3)c2=O)c(C)c1 | 10.1016/j.bmcl.2010.04.121 | |||
| 44190448 | 201912 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 439 | 4 | 0 | 6 | 4.2 | COc1cc(Br)c2c(c1)OCCN2c1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1021/jm900301y | |||
| CHEMBL550140 | 201912 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 439 | 4 | 0 | 6 | 4.2 | COc1cc(Br)c2c(c1)OCCN2c1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1021/jm900301y | |||
| 44191111 | 203258 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 362 | 4 | 1 | 5 | 4.4 | Cc1cc(Cl)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C#N | 10.1021/jm900302q | |||
| CHEMBL563313 | 203258 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 362 | 4 | 1 | 5 | 4.4 | Cc1cc(Cl)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C#N | 10.1021/jm900302q | |||
| 57397277 | 76766 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 381 | 6 | 0 | 5 | 5.3 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C(C)C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939586 | 76766 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 381 | 6 | 0 | 5 | 5.3 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C(C)C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 42618175 | 191563 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 413 | 10 | 1 | 8 | 3.6 | CCOCC(COCC)Nc1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL485140 | 191563 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 413 | 10 | 1 | 8 | 3.6 | CCOCC(COCC)Nc1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 9885105 | 104775 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 357 | 8 | 0 | 4 | 6.1 | CCOc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1 | 10.1021/jm070578k | |||
| CHEMBL272826 | 104775 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 357 | 8 | 0 | 4 | 6.1 | CCOc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1 | 10.1021/jm070578k | |||
| 11291949 | 134287 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL366155 | 134287 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 10216313 | 71129 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 410 | 7 | 0 | 6 | 4.5 | CCCC(CCC)n1c(CC)nc2c1c(=O)n(C)c(=O)n2-c1c(C)cc(C)cc1C | 10.1021/jm049787k | |||
| CHEMBL181258 | 71129 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 410 | 7 | 0 | 6 | 4.5 | CCCC(CCC)n1c(CC)nc2c1c(=O)n(C)c(=O)n2-c1c(C)cc(C)cc1C | 10.1021/jm049787k | |||
| 60156090 | 84351 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 536 | 11 | 0 | 9 | 5.4 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4(C#N)CC4)c(SC)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| CHEMBL2087798 | 84351 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 536 | 11 | 0 | 9 | 5.4 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4(C#N)CC4)c(SC)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| 11441103 | 182647 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 405 | 4 | 0 | 7 | 3.5 | COc1ccc(N2CCc3c(-n4ccc(N5CCOC5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| CHEMBL458600 | 182647 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 405 | 4 | 0 | 7 | 3.5 | COc1ccc(N2CCc3c(-n4ccc(N5CCOC5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| 70682070 | 82674 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 390 | 8 | 2 | 4 | 7.0 | CCCC(CCC)Nc1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)nc12 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2049189 | 82674 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 390 | 8 | 2 | 4 | 7.0 | CCCC(CCC)Nc1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)nc12 | 10.1016/j.bmcl.2012.05.066 | |||
| 11260682 | 18527 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 392 | 5 | 2 | 4 | 5.4 | CCC(CC)Nc1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL1181621 | 18527 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 392 | 5 | 2 | 4 | 5.4 | CCC(CC)Nc1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL185736 | 18527 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 392 | 5 | 2 | 4 | 5.4 | CCC(CC)Nc1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL526149 | 222454 | 10 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm9000242 | |||||
| 57390212 | 76782 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 367 | 5 | 0 | 5 | 4.5 | CCC(CC)c1cc(C)n2nc(-c3c(C)cc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939601 | 76782 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 367 | 5 | 0 | 5 | 4.5 | CCC(CC)c1cc(C)n2nc(-c3c(C)cc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL526149 | 222454 | 10 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm900025h | |||||
| 9949999 | 104359 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 343 | 7 | 0 | 4 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(OC)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL270764 | 104359 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 343 | 7 | 0 | 4 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(OC)cc2C)c1C | 10.1021/jm070578k | |||
| 9949999 | 104359 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 343 | 7 | 0 | 4 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(OC)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL270764 | 104359 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 343 | 7 | 0 | 4 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(OC)cc2C)c1C | 10.1021/jm070578k | |||
| 46891090 | 13593 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 418 | 7 | 1 | 6 | 5.0 | CCC(C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1083947 | 13593 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 418 | 7 | 1 | 6 | 5.0 | CCC(C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 46881794 | 14109 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 384 | 6 | 1 | 6 | 4.2 | Cc1cc(OC(F)F)nc(C)c1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1086181 | 14109 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 384 | 6 | 1 | 6 | 4.2 | Cc1cc(OC(F)F)nc(C)c1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| 44190146 | 204614 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 381 | 8 | 1 | 7 | 3.1 | COCC(COC)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL572347 | 204614 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 381 | 8 | 1 | 7 | 3.1 | COCC(COC)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| 42618179 | 191313 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 383 | 7 | 1 | 7 | 4.3 | CCCC(C)Nc1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL484781 | 191313 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 383 | 7 | 1 | 7 | 4.3 | CCCC(C)Nc1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 42618171 | 186776 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 378 | 7 | 0 | 7 | 3.9 | CCCN(CCC#N)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL474700 | 186776 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 378 | 7 | 0 | 7 | 3.9 | CCCN(CCC#N)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 24768332 | 92358 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 385 | 8 | 1 | 7 | 4.0 | CCCCN(CC)c1cc(C)nc2c1NCCN2c1ccc(OC)nc1OC | 10.1021/jm0611410 | |||
| CHEMBL228168 | 92358 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 385 | 8 | 1 | 7 | 4.0 | CCCCN(CC)c1cc(C)nc2c1NCCN2c1ccc(OC)nc1OC | 10.1021/jm0611410 | |||
| 11176967 | 74016 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.6 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C#N)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL187987 | 74016 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.6 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C#N)cc1Cl | 10.1021/jm049737f | |||
| 46891437 | 13184 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 399 | 7 | 1 | 8 | 2.7 | COC[C@@H](C1CC1)n1nc(C)nc(Nc2ccc(OC)nc2C(F)(F)F)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082358 | 13184 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 399 | 7 | 1 | 8 | 2.7 | COC[C@@H](C1CC1)n1nc(C)nc(Nc2ccc(OC)nc2C(F)(F)F)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 42618169 | 187616 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 367 | 7 | 0 | 6 | 4.4 | CCCCN(CC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL475705 | 187616 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 367 | 7 | 0 | 6 | 4.4 | CCCCN(CC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 44190916 | 203525 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 443 | 6 | 1 | 5 | 5.6 | CC[C@H](COC)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL565182 | 203525 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 443 | 6 | 1 | 5 | 5.6 | CC[C@H](COC)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 11588927 | 72281 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 377 | 7 | 1 | 6 | 5.4 | CCc1cc(OC)ccc1Nc1nc2ccnn2c2c1ccn2C(CC)CC | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830524 | 72281 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 377 | 7 | 1 | 6 | 5.4 | CCc1cc(OC)ccc1Nc1nc2ccnn2c2c1ccn2C(CC)CC | 10.1016/j.bmc.2011.08.055 | |||
| 71456930 | 88765 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 409 | 9 | 1 | 6 | 4.2 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OCCF)cc2C)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL2165196 | 88765 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 409 | 9 | 1 | 6 | 4.2 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OCCF)cc2C)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| 46891438 | 13185 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 413 | 8 | 1 | 8 | 3.1 | CCOc1ccc(Nc2nc(C)nn([C@@H](COC)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082359 | 13185 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 413 | 8 | 1 | 8 | 3.1 | CCOc1ccc(Nc2nc(C)nn([C@@H](COC)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 44190336 | 201710 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 345 | 5 | 1 | 4 | 4.9 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(C)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL541756 | 201710 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 345 | 5 | 1 | 4 | 4.9 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(C)cc2C)c1=O | 10.1021/jm900301y | |||
| 44189949 | 202740 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 361 | 7 | 1 | 4 | 5.7 | CCCC(CCC)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL559633 | 202740 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 361 | 7 | 1 | 4 | 5.7 | CCCC(CCC)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| 44190239 | 203416 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 382 | 4 | 1 | 5 | 4.8 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900301y | |||
| CHEMBL564303 | 203416 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 382 | 4 | 1 | 5 | 4.8 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900301y | |||
| 42618235 | 190971 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 382 | 8 | 0 | 7 | 4.1 | CCCCN(CCC)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL483162 | 190971 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 382 | 8 | 0 | 7 | 4.1 | CCCCN(CCC)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 44190239 | 203416 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 382 | 4 | 1 | 5 | 4.8 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL564303 | 203416 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 382 | 4 | 1 | 5 | 4.8 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 42618191 | 191138 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 394 | 7 | 0 | 8 | 3.5 | CCN(CCC#N)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL484421 | 191138 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 394 | 7 | 0 | 8 | 3.5 | CCN(CCC#N)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 42618168 | 187435 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 367 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL475506 | 187435 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 367 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 57393711 | 76750 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 353 | 5 | 0 | 5 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939570 | 76750 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 353 | 5 | 0 | 5 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 9952426 | 104479 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 391 | 6 | 0 | 3 | 6.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Br)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL271344 | 104479 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 391 | 6 | 0 | 3 | 6.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Br)cc2C)c1C | 10.1021/jm070578k | |||
| 11249766 | 18531 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 430 | 8 | 1 | 5 | 5.1 | CCCN(CCOC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL1181636 | 18531 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 430 | 8 | 1 | 5 | 5.1 | CCCN(CCOC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL186517 | 18531 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 430 | 8 | 1 | 5 | 5.1 | CCCN(CCOC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Cl | 10.1021/jm049737f | |||
| 9952426 | 104479 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 391 | 6 | 0 | 3 | 6.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Br)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL271344 | 104479 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 391 | 6 | 0 | 3 | 6.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Br)cc2C)c1C | 10.1021/jm070578k | |||
| 46891287 | 13653 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 397 | 6 | 1 | 7 | 3.8 | CCC(C1CC1)n1nc(C)nc(Nc2cc(C)c(OC)nc2C(F)(F)F)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1084203 | 13653 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 397 | 6 | 1 | 7 | 3.8 | CCC(C1CC1)n1nc(C)nc(Nc2cc(C)c(OC)nc2C(F)(F)F)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 46881747 | 12368 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 362 | 6 | 1 | 6 | 4.0 | CCOc1nc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1077249 | 12368 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 362 | 6 | 1 | 6 | 4.0 | CCOc1nc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2010.01.129 | |||
| 42618193 | 190937 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 413 | 9 | 0 | 8 | 3.1 | COCCN(CCOC)c1nc(C)nc2c(-c3c(C)cc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL482976 | 190937 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 413 | 9 | 0 | 8 | 3.1 | COCCN(CCOC)c1nc(C)nc2c(-c3c(C)cc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 44190149 | 201839 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 396 | 5 | 1 | 5 | 5.2 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900301y | |||
| CHEMBL549538 | 201839 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 396 | 5 | 1 | 5 | 5.2 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900301y | |||
| 136164073 | 14928 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 411 | 7 | 2 | 7 | 3.5 | COCC(COC)NC1NC(C)=Nc2c(-c3ccc(Cl)cc3Cl)c(C)nn21 | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1091818 | 14928 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 411 | 7 | 2 | 7 | 3.5 | COCC(COC)NC1NC(C)=Nc2c(-c3ccc(Cl)cc3Cl)c(C)nn21 | 10.1016/j.bmcl.2010.01.129 | |||
| 15485770 | 204373 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 333 | 5 | 1 | 4 | 4.9 | CCC(CC)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL570546 | 204373 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 333 | 5 | 1 | 4 | 4.9 | CCC(CC)n1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| 42618178 | 198468 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 369 | 6 | 1 | 7 | 3.9 | CC[C@H](C)Nc1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL519677 | 198468 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 369 | 6 | 1 | 7 | 3.9 | CC[C@H](C)Nc1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 44190827 | 202936 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 362 | 4 | 1 | 5 | 4.4 | Cc1cc(C#N)cc(Cl)c1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1021/jm900302q | |||
| CHEMBL561230 | 202936 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 362 | 4 | 1 | 5 | 4.4 | Cc1cc(C#N)cc(Cl)c1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1021/jm900302q | |||
| 58223380 | 134646 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 489 | 11 | 0 | 9 | 5.0 | COCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCCCC1 | nan | |||
| CHEMBL3664581 | 134646 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 489 | 11 | 0 | 9 | 5.0 | COCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCCCC1 | nan | |||
| 56663336 | 72084 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 387 | 8 | 0 | 6 | 4.8 | CCCN(CCC)c1cc(N(C)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828896 | 72084 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 387 | 8 | 0 | 6 | 4.8 | CCCN(CCC)c1cc(N(C)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 56683765 | 72279 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 388 | 8 | 0 | 7 | 4.2 | CCCN(CCC)c1nc(N(C)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830522 | 72279 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 388 | 8 | 0 | 7 | 4.2 | CCCN(CCC)c1nc(N(C)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 21984697 | 84325 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 409 | 9 | 0 | 4 | 5.8 | CCc1nn2c(-c3c(C)cc(C)cc3OC)cccc2c1N(CCCF)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087558 | 84325 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 409 | 9 | 0 | 4 | 5.8 | CCc1nn2c(-c3c(C)cc(C)cc3OC)cccc2c1N(CCCF)CC1CC1 | 10.1021/jm300259r | |||
| 46891336 | 13179 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 359 | 7 | 1 | 8 | 2.3 | COCC(C1CC1)n1nc(C)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082340 | 13179 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 359 | 7 | 1 | 8 | 2.3 | COCC(C1CC1)n1nc(C)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 46891092 | 14004 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 416 | 5 | 1 | 7 | 3.4 | Cc1nc(Nc2c(Cl)cc(S(C)(=O)=O)cc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1085734 | 14004 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 416 | 5 | 1 | 7 | 3.4 | Cc1nc(Nc2c(Cl)cc(S(C)(=O)=O)cc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 9885105 | 104775 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 357 | 8 | 0 | 4 | 6.1 | CCOc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1 | 10.1021/jm070578k | |||
| CHEMBL272826 | 104775 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 357 | 8 | 0 | 4 | 6.1 | CCOc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1 | 10.1021/jm070578k | |||
| 57786312 | 171745 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 423 | 4 | 0 | 4 | 6.6 | CCC(OC)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4225316 | 171745 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 423 | 4 | 0 | 4 | 6.6 | CCC(OC)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| 21084107 | 84333 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 479 | 10 | 1 | 7 | 4.7 | CCc1nn2c(-c3c(OC)cc(CO)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087566 | 84333 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 479 | 10 | 1 | 7 | 4.7 | CCc1nn2c(-c3c(OC)cc(CO)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| 11177197 | 174420 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 404 | 7 | 1 | 4 | 6.6 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Cl)cc3Cl)n(C)c12 | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4226111 | 174420 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 404 | 7 | 1 | 4 | 6.6 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Cl)cc3Cl)n(C)c12 | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4301639 | 174420 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 404 | 7 | 1 | 4 | 6.6 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Cl)cc3Cl)n(C)c12 | 10.1016/j.bmc.2018.01.020 | |||
| 71458704 | 88292 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 410 | 9 | 0 | 6 | 4.9 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)ccc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160167 | 88292 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 410 | 9 | 0 | 6 | 4.9 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)ccc12 | 10.1016/j.bmc.2012.09.028 | |||
| 44589304 | 182799 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 388 | 3 | 0 | 7 | 4.1 | N#Cc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(F)c1 | 10.1021/jm800743q | |||
| CHEMBL458981 | 182799 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 388 | 3 | 0 | 7 | 4.1 | N#Cc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(F)c1 | 10.1021/jm800743q | |||
| 53328045 | 137384 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 441 | 6 | 1 | 3 | 5.7 | CCc1cc(CC)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | |||
| CHEMBL3681389 | 137384 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 441 | 6 | 1 | 3 | 5.7 | CCc1cc(CC)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)n1 | nan | |||
| 71449777 | 88768 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 453 | 10 | 1 | 7 | 4.1 | COCC(COC)n1cc(Cl)nc(Nc2c(Cl)cc(OCCF)cc2Cl)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL2165199 | 88768 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 453 | 10 | 1 | 7 | 4.1 | COCC(COC)n1cc(Cl)nc(Nc2c(Cl)cc(OCCF)cc2Cl)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| 24768338 | 92315 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 415 | 9 | 1 | 8 | 3.5 | CCCN(CCOC)c1nc(C)nc2c1NCCN2c1cc(OC)c(OC)cc1C | 10.1021/jm0611410 | |||
| CHEMBL227724 | 92315 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 415 | 9 | 1 | 8 | 3.5 | CCCN(CCOC)c1nc(C)nc2c1NCCN2c1cc(OC)c(OC)cc1C | 10.1021/jm0611410 | |||
| 57786300 | 171727 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 3 | 0 | 4 | 6.1 | CCC(=O)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4224989 | 171727 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 3 | 0 | 4 | 6.1 | CCC(=O)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| 57785808 | 171728 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 489 | 5 | 0 | 6 | 6.0 | CCc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc(C(OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4225039 | 171728 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 489 | 5 | 0 | 6 | 6.0 | CCc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc(C(OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | |||
| 70690703 | 83385 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 380 | 6 | 0 | 5 | 4.7 | COCc1cc(OC)c(-c2nc3c(C)ccc(N(C)C)c3cc2C)c(OC)c1 | 10.1016/j.bmcl.2012.07.047 | |||
| CHEMBL2063371 | 83385 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 380 | 6 | 0 | 5 | 4.7 | COCc1cc(OC)c(-c2nc3c(C)ccc(N(C)C)c3cc2C)c(OC)c1 | 10.1016/j.bmcl.2012.07.047 | |||
| 56683689 | 72089 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 427 | 10 | 0 | 6 | 5.6 | CCCN(CCC)c1cc(N(CC2CC2)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828901 | 72089 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 427 | 10 | 0 | 6 | 5.6 | CCCN(CCC)c1cc(N(CC2CC2)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 44589306 | 181767 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 406 | 5 | 0 | 9 | 3.5 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(OC)n1 | 10.1021/jm800743q | |||
| CHEMBL456651 | 181767 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 406 | 5 | 0 | 9 | 3.5 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(OC)n1 | 10.1021/jm800743q | |||
| 53358856 | 137374 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 413 | 4 | 1 | 3 | 5.2 | Cc1cnn(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1C | nan | |||
| CHEMBL3681379 | 137374 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 413 | 4 | 1 | 3 | 5.2 | Cc1cnn(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c1C | nan | |||
| 58896446 | 146283 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 412 | 8 | 1 | 4 | 7.0 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Cl)cc3C(C)C)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3792636 | 146283 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 412 | 8 | 1 | 4 | 7.0 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Cl)cc3C(C)C)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3794595 | 146283 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 412 | 8 | 1 | 4 | 7.0 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Cl)cc3C(C)C)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 60155708 | 84328 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 447 | 8 | 0 | 5 | 5.8 | CCc1nn2c(-c3c(C)cc(C)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087561 | 84328 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 447 | 8 | 0 | 5 | 5.8 | CCc1nn2c(-c3c(C)cc(C)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| 60155709 | 84329 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 463 | 9 | 0 | 6 | 5.5 | CCc1nn2c(-c3c(OC)cc(C)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087562 | 84329 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 463 | 9 | 0 | 6 | 5.5 | CCc1nn2c(-c3c(OC)cc(C)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| 10135150 | 71525 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 392 | 6 | 1 | 5 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4cc(C)c(OC)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819075 | 71525 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 392 | 6 | 1 | 5 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4cc(C)c(OC)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 22177742 | 71536 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 400 | 6 | 1 | 6 | 5.0 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4Cl)c(C)nn13)COC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819087 | 71536 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 400 | 6 | 1 | 6 | 5.0 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4Cl)c(C)nn13)COC2 | 10.1016/j.bmc.2011.07.055 | |||
| 24964084 | 163323 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 419 | 6 | 1 | 4 | 6.0 | CCC(CC)c1ccc(Cl)c2nc(Oc3c(C)cc(C(N)=O)cc3Cl)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4068170 | 163323 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 419 | 6 | 1 | 4 | 6.0 | CCC(CC)c1ccc(Cl)c2nc(Oc3c(C)cc(C(N)=O)cc3Cl)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 11948286 | 163448 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 410 | 5 | 0 | 3 | 7.5 | CCC(CC)c1ccc(Cl)c2nc(Oc3c(C)cc(Cl)cc3Cl)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4069551 | 163448 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 410 | 5 | 0 | 3 | 7.5 | CCC(CC)c1ccc(Cl)c2nc(Oc3c(C)cc(Cl)cc3Cl)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 53357920 | 137389 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 427 | 5 | 1 | 3 | 5.4 | CCc1cc(C)nn1C[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | |||
| CHEMBL3681394 | 137389 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 427 | 5 | 1 | 3 | 5.4 | CCc1cc(C)nn1C[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | |||
| 10294192 | 71980 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 396 | 7 | 0 | 4 | 5.7 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)CN2c1c(C)cc(C)cc1C | 10.1021/jm049787k | |||
| CHEMBL182550 | 71980 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 396 | 7 | 0 | 4 | 5.7 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)CN2c1c(C)cc(C)cc1C | 10.1021/jm049787k | |||
| 58896429 | 180104 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 510 | 7 | 1 | 6 | 7.1 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(CC3CCOC3)c3ccc(Cl)cc3)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4526475 | 180104 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 510 | 7 | 1 | 6 | 7.1 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(CC3CCOC3)c3ccc(Cl)cc3)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| 58896417 | 146279 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 426 | 8 | 1 | 4 | 7.3 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)n(-c3ccccc3)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3793751 | 146279 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 426 | 8 | 1 | 4 | 7.3 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)n(-c3ccccc3)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3794591 | 146279 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 426 | 8 | 1 | 4 | 7.3 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)n(-c3ccccc3)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 58223481 | 89374 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 517 | 11 | 1 | 10 | 4.0 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4(O)CCOCC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| CHEMBL2179177 | 89374 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 517 | 11 | 1 | 10 | 4.0 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4(O)CCOCC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| 44589331 | 182259 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 378 | 3 | 0 | 6 | 4.2 | Cc1cc(C#N)ccc1N1CCc2c(-n3ccc(-c4ccccn4)n3)ccnc21 | 10.1021/jm800743q | |||
| CHEMBL457741 | 182259 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 378 | 3 | 0 | 6 | 4.2 | Cc1cc(C#N)ccc1N1CCc2c(-n3ccc(-c4ccccn4)n3)ccnc21 | 10.1021/jm800743q | |||
| 71453343 | 88286 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 8 | 0 | 5 | 5.4 | CCN(CC)c1ccc(F)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160160 | 88286 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 8 | 0 | 5 | 5.4 | CCN(CC)c1ccc(F)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 44589239 | 197269 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 404 | 3 | 0 | 7 | 4.6 | N#Cc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(Cl)c1 | 10.1021/jm800743q | |||
| CHEMBL517910 | 197269 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 404 | 3 | 0 | 7 | 4.6 | N#Cc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(Cl)c1 | 10.1021/jm800743q | |||
| 46891491 | 13718 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 383 | 6 | 1 | 7 | 3.5 | CCOc1ccc(Nc2nc(C)nn([C@@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1084500 | 13718 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 383 | 6 | 1 | 7 | 3.5 | CCOc1ccc(Nc2nc(C)nn([C@@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 46891390 | 13894 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 434 | 8 | 1 | 7 | 4.2 | COC[C@@H](C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1085244 | 13894 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 434 | 8 | 1 | 7 | 4.2 | COC[C@@H](C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 42618217 | 191402 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 400 | 9 | 0 | 9 | 2.2 | COCCN(CCOC)c1nc(C)nc2c(-c3cnc(OC)cc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL484930 | 191402 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 400 | 9 | 0 | 9 | 2.2 | COCCN(CCOC)c1nc(C)nc2c(-c3cnc(OC)cc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 44589256 | 196421 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 457 | 4 | 0 | 8 | 4.1 | CS(=O)(=O)c1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(Cl)c1 | 10.1021/jm800743q | |||
| CHEMBL515070 | 196421 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 457 | 4 | 0 | 8 | 4.1 | CS(=O)(=O)c1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(Cl)c1 | 10.1021/jm800743q | |||
| 58223424 | 134649 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 431 | 9 | 0 | 8 | 4.6 | CCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCC1 | nan | |||
| CHEMBL3664584 | 134649 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 431 | 9 | 0 | 8 | 4.6 | CCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCC1 | nan | |||
| 127030314 | 146167 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 6 | 1 | 5 | 5.8 | CCN(CC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3793277 | 146167 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 6 | 1 | 5 | 5.8 | CCN(CC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 21984771 | 84320 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 403 | 8 | 0 | 4 | 5.8 | CCc1nn2c(-c3c(C)cc(C)cc3OC)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087553 | 84320 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 403 | 8 | 0 | 4 | 5.8 | CCc1nn2c(-c3c(C)cc(C)cc3OC)cccc2c1N(CC1CC1)CC1CC1 | 10.1021/jm300259r | |||
| 127030314 | 146167 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 6 | 1 | 5 | 5.8 | CCN(CC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL3793277 | 146167 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 6 | 1 | 5 | 5.8 | CCN(CC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 42618176 | 191133 | 1 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 337 | 4 | 1 | 6 | 3.7 | COc1ccc(-c2c(C)nn3c(NC4CCC4)nc(C)nc23)c(C)c1 | 10.1021/jm9000242 | |||
| CHEMBL484407 | 191133 | 1 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 337 | 4 | 1 | 6 | 3.7 | COc1ccc(-c2c(C)nn3c(NC4CCC4)nc(C)nc23)c(C)c1 | 10.1021/jm9000242 | |||
| 42618216 | 198898 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 1 | 7 | 3.8 | CCC(CC)Nc1nc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL520344 | 198898 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 367 | 6 | 1 | 7 | 3.8 | CCC(CC)Nc1nc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 22177988 | 71516 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 6 | 1 | 5 | 4.8 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)cnn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819066 | 71516 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 6 | 1 | 5 | 4.8 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)cnn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 46881863 | 12374 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 365 | 6 | 1 | 8 | 2.7 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(OC)n1 | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1077299 | 12374 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 365 | 6 | 1 | 8 | 2.7 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(OC)n1 | 10.1016/j.bmcl.2010.01.129 | |||
| 90654669 | 116851 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 9 | 1 | 5 | 6.2 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)c1SCC | 10.1016/j.ejmech.2014.03.040 | |||
| CHEMBL3235706 | 116851 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 9 | 1 | 5 | 6.2 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)c1SCC | 10.1016/j.ejmech.2014.03.040 | |||
| 70688637 | 83391 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 490 | 9 | 0 | 6 | 6.1 | COCc1cc(OC)c(-c2nc3c(C)ccc(N(CC4CC4)C4CCOCC4)c3cc2C)c(OC)c1 | 10.1016/j.bmcl.2012.07.047 | |||
| CHEMBL2063377 | 83391 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 490 | 9 | 0 | 6 | 6.1 | COCc1cc(OC)c(-c2nc3c(C)ccc(N(CC4CC4)C4CCOCC4)c3cc2C)c(OC)c1 | 10.1016/j.bmcl.2012.07.047 | |||
| 58223432 | 134634 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 477 | 14 | 0 | 9 | 4.9 | CCCCN(CCOC)c1c(OC)nn2c(-c3c(OC)cc(COCC)cc3OC)csc12 | nan | |||
| CHEMBL3664569 | 134634 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 477 | 14 | 0 | 9 | 4.9 | CCCCN(CCOC)c1c(OC)nn2c(-c3c(OC)cc(COCC)cc3OC)csc12 | nan | |||
| 58223378 | 134641 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 475 | 12 | 0 | 9 | 4.5 | COCCN(CC1CCC1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| CHEMBL3664576 | 134641 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 475 | 12 | 0 | 9 | 4.5 | COCCN(CC1CCC1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| 60155887 | 84348 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 465 | 9 | 0 | 7 | 5.0 | COc1cc(C)cc(OC)c1-c1cccc2c(N(CC3CCOCC3)CC3CC3)c(OC)nn12 | 10.1021/jm300259r | |||
| CHEMBL2087795 | 84348 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 465 | 9 | 0 | 7 | 5.0 | COc1cc(C)cc(OC)c1-c1cccc2c(N(CC3CCOCC3)CC3CC3)c(OC)nn12 | 10.1021/jm300259r | |||
| 21912058 | 104475 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 356 | 7 | 0 | 4 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1N(C)C | 10.1021/jm070578k | |||
| CHEMBL271329 | 104475 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 356 | 7 | 0 | 4 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1N(C)C | 10.1021/jm070578k | |||
| 155552287 | 180851 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 465 | 7 | 1 | 7 | 6.2 | COc1ccc(N(c2cccc3nc(Nc4c(C)cc(Cl)cc4OC)n(C)c23)C(C)C)cn1 | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4544244 | 180851 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 465 | 7 | 1 | 7 | 6.2 | COc1ccc(N(c2cccc3nc(Nc4c(C)cc(Cl)cc4OC)n(C)c23)C(C)C)cn1 | 10.1016/j.bmc.2016.08.005 | |||
| 58896465 | 182875 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 468 | 6 | 1 | 5 | 7.5 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(c3ccc(Cl)cc3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4591335 | 182875 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 468 | 6 | 1 | 5 | 7.5 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(c3ccc(Cl)cc3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| 10204603 | 70119 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 456 | 4 | 0 | 4 | 6.8 | CCC(CC)n1cc2c3c(nc(C)nc31)N(c1ccc(C(F)(F)F)cc1C(F)(F)F)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL179435 | 70119 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 456 | 4 | 0 | 4 | 6.8 | CCC(CC)n1cc2c3c(nc(C)nc31)N(c1ccc(C(F)(F)F)cc1C(F)(F)F)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| 21912058 | 104475 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 356 | 7 | 0 | 4 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1N(C)C | 10.1021/jm070578k | |||
| CHEMBL271329 | 104475 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 356 | 7 | 0 | 4 | 5.7 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1N(C)C | 10.1021/jm070578k | |||
| 42618207 | 186585 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 381 | 6 | 1 | 7 | 4.1 | CCC(CC)Nc1nc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL474491 | 186585 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 381 | 6 | 1 | 7 | 4.1 | CCC(CC)Nc1nc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 58896492 | 146278 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 350 | 7 | 2 | 3 | 5.9 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)[nH]c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3793362 | 146278 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 350 | 7 | 2 | 3 | 5.9 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)[nH]c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3794590 | 146278 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 350 | 7 | 2 | 3 | 5.9 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)[nH]c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 71457263 | 89391 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 445 | 9 | 0 | 8 | 4.6 | CCCN(c1c(OC)nn2c(-c3ccc(COC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| CHEMBL2179194 | 89391 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 445 | 9 | 0 | 8 | 4.6 | CCCN(c1c(OC)nn2c(-c3ccc(COC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| 58317279 | 133315 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 394 | 4 | 1 | 4 | 4.5 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2nc(C)c(Cl)c2C)CC1 | nan | |||
| CHEMBL3652115 | 133315 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 394 | 4 | 1 | 4 | 4.5 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2nc(C)c(Cl)c2C)CC1 | nan | |||
| 44589329 | 182421 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 403 | 4 | 0 | 8 | 3.9 | Cc1nc(N(C)C)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| CHEMBL458101 | 182421 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 403 | 4 | 0 | 8 | 3.9 | Cc1nc(N(C)C)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| 44589223 | 196304 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 443 | 4 | 0 | 7 | 5.3 | Cc1cc(OC(F)(F)F)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| CHEMBL514126 | 196304 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 443 | 4 | 0 | 7 | 5.3 | Cc1cc(OC(F)(F)F)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| 58223390 | 134622 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 433 | 11 | 0 | 8 | 4.9 | CCCN(CCC)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| CHEMBL3664557 | 134622 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 433 | 11 | 0 | 8 | 4.9 | CCCN(CCC)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| 58223381 | 134639 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 475 | 11 | 0 | 9 | 4.6 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(COCC)cc3OC)csc12)C1CCOC1 | nan | |||
| CHEMBL3664574 | 134639 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 475 | 11 | 0 | 9 | 4.6 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(COCC)cc3OC)csc12)C1CCOC1 | nan | |||
| 58223490 | 134656 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 445 | 9 | 0 | 8 | 5.0 | CCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCCC1 | nan | |||
| CHEMBL3664590 | 134656 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 445 | 9 | 0 | 8 | 5.0 | CCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCCC1 | nan | |||
| 46891288 | 13654 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 329 | 5 | 1 | 7 | 2.7 | COc1nc(C)c(Nc2nc(C)nn(C(C)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1084204 | 13654 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 329 | 5 | 1 | 7 | 2.7 | COc1nc(C)c(Nc2nc(C)nn(C(C)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2010.04.121 | |||
| 11304337 | 71621 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 4 | 0 | 4 | 5.3 | CCc1nc2c(n1C(C)C1CCC1)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL182068 | 71621 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 4 | 0 | 4 | 5.3 | CCc1nc2c(n1C(C)C1CCC1)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 46891229 | 13320 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 407 | 4 | 1 | 6 | 4.4 | Cc1nc(Nc2c(Cl)cc(C(F)(F)F)nc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082956 | 13320 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 407 | 4 | 1 | 6 | 4.4 | Cc1nc(Nc2c(Cl)cc(C(F)(F)F)nc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 53357410 | 133316 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 360 | 4 | 1 | 4 | 3.8 | Cc1cc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)n1 | nan | |||
| CHEMBL3652116 | 133316 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 360 | 4 | 1 | 4 | 3.8 | Cc1cc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)n1 | nan | |||
| 60155989 | 84352 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 513 | 11 | 0 | 9 | 4.5 | COCc1cc(OC)c(-c2cccc3c(N(CC4CC4)CC4COCCO4)c(SC)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| CHEMBL2087799 | 84352 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 513 | 11 | 0 | 9 | 4.5 | COCc1cc(OC)c(-c2cccc3c(N(CC4CC4)CC4COCCO4)c(SC)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| 46891552 | 14114 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 413 | 8 | 1 | 8 | 3.1 | CCOc1ccc(Nc2nc(C)nn([C@H](COC)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1086239 | 14114 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 413 | 8 | 1 | 8 | 3.1 | CCOc1ccc(Nc2nc(C)nn([C@H](COC)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 58896411 | 182984 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 464 | 7 | 1 | 6 | 6.8 | COc1ccc(N(c2cccc3nc(Nc4c(C)cc(Cl)cc4OC)n(C)c23)C(C)C)cc1 | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4593848 | 182984 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 464 | 7 | 1 | 6 | 6.8 | COc1ccc(N(c2cccc3nc(Nc4c(C)cc(Cl)cc4OC)n(C)c23)C(C)C)cc1 | 10.1016/j.bmc.2016.08.005 | |||
| 10136833 | 129121 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 418 | 8 | 0 | 5 | 5.4 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(OC)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL359923 | 129121 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 418 | 8 | 0 | 5 | 5.4 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(OC)cc1Cl | 10.1021/jm049787k | |||
| 44589092 | 182794 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 481 | 3 | 0 | 6 | 6.1 | FC(F)(F)c1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C(F)(F)F)c1 | 10.1021/jm800743q | |||
| CHEMBL458968 | 182794 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 481 | 3 | 0 | 6 | 6.1 | FC(F)(F)c1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C(F)(F)F)c1 | 10.1021/jm800743q | |||
| 46891187 | 13415 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 3.8 | Cc1nc(Nc2cc(Cl)c(C#N)cc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1083342 | 13415 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 3.8 | Cc1nc(Nc2cc(Cl)c(C#N)cc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 137635894 | 162690 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 507 | 7 | 1 | 6 | 5.0 | CCN(CC(=O)N(C)C)c1ccc(Br)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4060825 | 162690 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 507 | 7 | 1 | 6 | 5.0 | CCN(CC(=O)N(C)C)c1ccc(Br)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 57786068 | 171826 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 389 | 4 | 0 | 4 | 5.3 | CCN(CC)c1cccc2nc3n(c12)CCOC3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4226353 | 171826 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 389 | 4 | 0 | 4 | 5.3 | CCN(CC)c1cccc2nc3n(c12)CCOC3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| 90654666 | 116848 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 404 | 10 | 1 | 7 | 4.3 | COCCN(CCOC)c1nc(C)nc(Nc2c(C)cc(C)cc2C)c1SC | 10.1016/j.ejmech.2014.03.040 | |||
| CHEMBL3235700 | 116848 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 404 | 10 | 1 | 7 | 4.3 | COCCN(CCOC)c1nc(C)nc(Nc2c(C)cc(C)cc2C)c1SC | 10.1016/j.ejmech.2014.03.040 | |||
| 25149257 | 196322 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 397 | 3 | 0 | 8 | 4.2 | Cc1cc(-n2ccc(-c3nccs3)n2)c2cnn(-c3ccc(C#N)cc3C)c2n1 | 10.1021/jm800743q | |||
| CHEMBL514272 | 196322 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 397 | 3 | 0 | 8 | 4.2 | Cc1cc(-n2ccc(-c3nccs3)n2)c2cnn(-c3ccc(C#N)cc3C)c2n1 | 10.1021/jm800743q | |||
| 70692845 | 83382 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 422 | 10 | 0 | 5 | 6.0 | CCCN(CCC)c1cccc2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| CHEMBL2063368 | 83382 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 422 | 10 | 0 | 5 | 6.0 | CCCN(CCC)c1cccc2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| 46891156 | 14009 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 342 | 6 | 1 | 6 | 3.7 | CCOc1cc(C)c(Nc2nc(C)nn(C(C)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1085754 | 14009 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 342 | 6 | 1 | 6 | 3.7 | CCOc1cc(C)c(Nc2nc(C)nn(C(C)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2010.04.121 | |||
| 21912152 | 102737 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 313 | 5 | 0 | 3 | 5.6 | CCC(C)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL259467 | 102737 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 313 | 5 | 0 | 3 | 5.6 | CCC(C)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| 3520 | 10041 | 54 | None | 1 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm800744m | |||
| 9821250 | 10041 | 54 | None | 1 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm800744m | |||
| CHEMBL309138 | 10041 | 54 | None | 1 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm800744m | |||
| 21912152 | 102737 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 313 | 5 | 0 | 3 | 5.6 | CCC(C)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL259467 | 102737 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 313 | 5 | 0 | 3 | 5.6 | CCC(C)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| 44190339 | 202899 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 363 | 6 | 2 | 6 | 3.6 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(O)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL561024 | 202899 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 363 | 6 | 2 | 6 | 3.6 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(O)cc2C)c1=O | 10.1021/jm900301y | |||
| 70692847 | 83390 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 504 | 10 | 0 | 6 | 6.3 | COCc1cc(OC)c(-c2nc3c(C)ccc(N(CC4CCOCC4)CC4CC4)c3cc2C)c(OC)c1 | 10.1016/j.bmcl.2012.07.047 | |||
| CHEMBL2063376 | 83390 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 504 | 10 | 0 | 6 | 6.3 | COCc1cc(OC)c(-c2nc3c(C)ccc(N(CC4CCOCC4)CC4CC4)c3cc2C)c(OC)c1 | 10.1016/j.bmcl.2012.07.047 | |||
| 71458702 | 88289 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 462 | 8 | 0 | 5 | 6.2 | CCN(CC)c1ccc(C(F)(F)F)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160163 | 88289 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 462 | 8 | 0 | 5 | 6.2 | CCN(CC)c1ccc(C(F)(F)F)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 11774042 | 210131 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL65078 | 210131 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm040058e | |||
| 58223393 | 134610 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 465 | 10 | 1 | 8 | 4.6 | CCCN(CCC)c1c(C)nn2c(-c3c(O)cc(COC)cc3OC)c([S+](C)[O-])sc12 | nan | |||
| CHEMBL3664545 | 134610 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 465 | 10 | 1 | 8 | 4.6 | CCCN(CCC)c1c(C)nn2c(-c3c(O)cc(COC)cc3OC)c([S+](C)[O-])sc12 | nan | |||
| 10309819 | 71990 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 408 | 5 | 0 | 6 | 4.1 | CCc1nc2c(c(=O)n(C)c(=O)n2-c2ccc(Cl)cc2Cl)n1C(CC)CC | 10.1021/jm049787k | |||
| CHEMBL182591 | 71990 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 408 | 5 | 0 | 6 | 4.1 | CCc1nc2c(c(=O)n(C)c(=O)n2-c2ccc(Cl)cc2Cl)n1C(CC)CC | 10.1021/jm049787k | |||
| 56668632 | 71532 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 434 | 7 | 1 | 5 | 6.0 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC(F)F)cc4Cl)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819083 | 71532 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 434 | 7 | 1 | 5 | 6.0 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC(F)F)cc4Cl)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 46891286 | 13395 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 413 | 8 | 1 | 8 | 3.1 | CCOc1ccc(Nc2nc(C)nn(C(COC)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1083293 | 13395 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 413 | 8 | 1 | 8 | 3.1 | CCOc1ccc(Nc2nc(C)nn(C(COC)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 42618219 | 190913 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 354 | 6 | 1 | 7 | 3.7 | CCC(CC)Nc1nc(C)nc2c(-c3cnc(OC)cc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL482752 | 190913 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 354 | 6 | 1 | 7 | 3.7 | CCC(CC)Nc1nc(C)nc2c(-c3cnc(OC)cc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 42618229 | 196576 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 396 | 8 | 0 | 8 | 3.0 | COCCN(CC1CC1)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL516242 | 196576 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 396 | 8 | 0 | 8 | 3.0 | COCCN(CC1CC1)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 42618220 | 198663 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 354 | 6 | 1 | 7 | 3.7 | CCC(CC)Nc1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL519967 | 198663 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 354 | 6 | 1 | 7 | 3.7 | CCC(CC)Nc1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 44190730 | 202752 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 331 | 4 | 1 | 4 | 4.5 | Cc1cn([C@H](C)C2CC2)c(=O)c(Nc2c(C)cc(Cl)cc2C)n1 | 10.1021/jm900302q | |||
| CHEMBL559701 | 202752 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 331 | 4 | 1 | 4 | 4.5 | Cc1cn([C@H](C)C2CC2)c(=O)c(Nc2c(C)cc(Cl)cc2C)n1 | 10.1021/jm900302q | |||
| 21912269 | 175689 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 357 | 8 | 0 | 4 | 5.8 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(COC)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL438553 | 175689 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 357 | 8 | 0 | 4 | 5.8 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(COC)cc2C)c1C | 10.1021/jm070578k | |||
| 11153312 | 72280 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 383 | 6 | 1 | 6 | 5.5 | CCC(CC)n1ccc2c(Nc3ccc(OC)cc3Cl)nc3ccnn3c21 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830523 | 72280 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 383 | 6 | 1 | 6 | 5.5 | CCC(CC)n1ccc2c(Nc3ccc(OC)cc3Cl)nc3ccnn3c21 | 10.1016/j.bmc.2011.08.055 | |||
| 71580316 | 95216 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 441 | 8 | 0 | 6 | 4.2 | COc1cc(Cl)c2c(c1)CCN2c1nc(Cl)cn([C@@H](COCCF)C2CC2)c1=O | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL2349567 | 95216 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 441 | 8 | 0 | 6 | 4.2 | COc1cc(Cl)c2c(c1)CCN2c1nc(Cl)cn([C@@H](COCCF)C2CC2)c1=O | 10.1016/j.bmcl.2013.02.009 | |||
| 21912269 | 175689 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 357 | 8 | 0 | 4 | 5.8 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(COC)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL438553 | 175689 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 357 | 8 | 0 | 4 | 5.8 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(COC)cc2C)c1C | 10.1021/jm070578k | |||
| 42618192 | 199372 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.5 | CCC1CCCCN1c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL521457 | 199372 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 409 | 5 | 0 | 7 | 4.5 | CCC1CCCCN1c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 57398971 | 76770 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 393 | 7 | 0 | 5 | 5.1 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC3CC3)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939590 | 76770 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 393 | 7 | 0 | 5 | 5.1 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC3CC3)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 24768339 | 92341 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 377 | 6 | 1 | 5 | 4.3 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C#N)cc1C | 10.1021/jm0611410 | |||
| CHEMBL227946 | 92341 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 377 | 6 | 1 | 5 | 4.3 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C#N)cc1C | 10.1021/jm0611410 | |||
| 11421422 | 18537 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 5.3 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1c(Cl)cc(C#N)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL1181649 | 18537 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 5.3 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1c(Cl)cc(C#N)cc1Cl | 10.1021/jm049737f | |||
| CHEMBL187410 | 18537 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 5.3 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1c(Cl)cc(C#N)cc1Cl | 10.1021/jm049737f | |||
| 9820671 | 195597 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 369 | 6 | 1 | 7 | 3.9 | CC[C@@H](C)Nc1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL506214 | 195597 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 369 | 6 | 1 | 7 | 3.9 | CC[C@@H](C)Nc1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 24768340 | 149703 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 363 | 6 | 1 | 5 | 4.8 | CCCCN(CC)c1cc(C)nc2c1NCCN2c1ccc(C#N)cc1C | 10.1021/jm0611410 | |||
| CHEMBL389387 | 149703 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 363 | 6 | 1 | 5 | 4.8 | CCCCN(CC)c1cc(C)nc2c1NCCN2c1ccc(C#N)cc1C | 10.1021/jm0611410 | |||
| 46891387 | 13256 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 369 | 5 | 1 | 7 | 3.1 | COc1ccc(Nc2nc(C)nn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082669 | 13256 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 369 | 5 | 1 | 7 | 3.1 | COc1ccc(Nc2nc(C)nn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 42618223 | 186054 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 354 | 6 | 1 | 7 | 3.7 | CCCC(C)Nc1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL473069 | 186054 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 354 | 6 | 1 | 7 | 3.7 | CCCC(C)Nc1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 46891285 | 13394 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 397 | 7 | 1 | 7 | 3.9 | CCOc1ccc(Nc2nc(C)nn(C(CC)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1083292 | 13394 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 397 | 7 | 1 | 7 | 3.9 | CCOc1ccc(Nc2nc(C)nn(C(CC)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 46891231 | 13468 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 383 | 6 | 1 | 7 | 3.5 | CCC(C1CC1)n1nc(C)nc(Nc2ccc(OC)nc2C(F)(F)F)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1083590 | 13468 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 383 | 6 | 1 | 7 | 3.5 | CCC(C1CC1)n1nc(C)nc(Nc2ccc(OC)nc2C(F)(F)F)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 46891232 | 13469 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 399 | 7 | 1 | 8 | 2.7 | COCC(C1CC1)n1nc(C)nc(Nc2ccc(OC)nc2C(F)(F)F)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1083591 | 13469 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 399 | 7 | 1 | 8 | 2.7 | COCC(C1CC1)n1nc(C)nc(Nc2ccc(OC)nc2C(F)(F)F)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 9858549 | 104446 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 326 | 6 | 1 | 3 | 5.9 | CCC(CC)Oc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C | 10.1021/jm070579c | |||
| CHEMBL271197 | 104446 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 326 | 6 | 1 | 3 | 5.9 | CCC(CC)Oc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C | 10.1021/jm070579c | |||
| 44191009 | 202997 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 455 | 7 | 1 | 4 | 7.1 | CCCC(CCC)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL561553 | 202997 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 455 | 7 | 1 | 4 | 7.1 | CCCC(CCC)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 9858549 | 104446 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 326 | 6 | 1 | 3 | 5.9 | CCC(CC)Oc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C | 10.1021/jm070579c | |||
| CHEMBL271197 | 104446 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 326 | 6 | 1 | 3 | 5.9 | CCC(CC)Oc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C | 10.1021/jm070579c | |||
| 42618182 | 198680 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 397 | 8 | 0 | 7 | 4.4 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL519999 | 198680 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 397 | 8 | 0 | 7 | 4.4 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 57397276 | 76751 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 373 | 5 | 0 | 5 | 4.6 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939571 | 76751 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 373 | 5 | 0 | 5 | 4.6 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 57393713 | 76773 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 354 | 5 | 0 | 6 | 3.6 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939593 | 76773 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 354 | 5 | 0 | 6 | 3.6 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 44190556 | 202757 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 368 | 5 | 1 | 6 | 3.7 | COc1ccc(Nc2nc(C)cn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1021/jm900301y | |||
| CHEMBL559765 | 202757 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 368 | 5 | 1 | 6 | 3.7 | COc1ccc(Nc2nc(C)cn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1021/jm900301y | |||
| 42618166 | 179721 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 339 | 6 | 1 | 6 | 4.0 | CCC(CC)Nc1nc(C)nc2c(-c3ccc(OC)cc3)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL451693 | 179721 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 339 | 6 | 1 | 6 | 4.0 | CCC(CC)Nc1nc(C)nc2c(-c3ccc(OC)cc3)c(C)nn12 | 10.1021/jm9000242 | |||
| 24180501 | 101252 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 386 | 6 | 0 | 4 | 6.4 | CCCC(CCC)n1cc2c3c(nc(C)cc31)N(c1ccc(C#N)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL251386 | 101252 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 386 | 6 | 0 | 4 | 6.4 | CCCC(CCC)n1cc2c3c(nc(C)cc31)N(c1ccc(C#N)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| 24768328 | 104482 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 391 | 7 | 3 | 5 | 4.0 | CC[C@@H](CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)NC | 10.1021/jm070579c | |||
| CHEMBL271370 | 104482 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 391 | 7 | 3 | 5 | 4.0 | CC[C@@H](CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)NC | 10.1021/jm070579c | |||
| 3663 | 106743 | 83 | None | - | 28 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 504 | 0 | 6 | 8 | 5.1 | Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 | 10.1021/np1000329 | |||
| CHEMBL286494 | 106743 | 83 | None | - | 28 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 504 | 0 | 6 | 8 | 5.1 | Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 | 10.1021/np1000329 | |||
| 54585866 | 67431 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 398 | 8 | 0 | 7 | 3.6 | CCCN(CCC)c1nc2c(c(-c3ccc(OC)cc3OC)cn2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| CHEMBL1760261 | 67431 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 398 | 8 | 0 | 7 | 3.6 | CCCN(CCC)c1nc2c(c(-c3ccc(OC)cc3OC)cn2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| 54579975 | 67432 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 474 | 6 | 0 | 5 | 5.6 | CCCN(CCC)c1nc2c(c(-c3ccc(C(F)(F)F)cc3C(F)(F)F)cn2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| CHEMBL1760262 | 67432 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 474 | 6 | 0 | 5 | 5.6 | CCCN(CCC)c1nc2c(c(-c3ccc(C(F)(F)F)cc3C(F)(F)F)cn2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| 11250707 | 19039 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 522 | 8 | 1 | 6 | 4.6 | CCN(CCCS(C)(=O)=O)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Br | 10.1021/jm049737f | |||
| CHEMBL1184720 | 19039 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 522 | 8 | 1 | 6 | 4.6 | CCN(CCCS(C)(=O)=O)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Br | 10.1021/jm049737f | |||
| CHEMBL365488 | 19039 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 522 | 8 | 1 | 6 | 4.6 | CCN(CCCS(C)(=O)=O)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Br | 10.1021/jm049737f | |||
| 56666769 | 72082 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 441 | 9 | 1 | 6 | 6.4 | CCCN(CCC)c1c(C2CCCC2)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828894 | 72082 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 441 | 9 | 1 | 6 | 6.4 | CCCN(CCC)c1c(C2CCCC2)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 11247672 | 181685 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 440 | 4 | 1 | 7 | 2.2 | COc1ccc(N2CCc3c(-n4ccc(N5CCNS5(=O)=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| CHEMBL456449 | 181685 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 440 | 4 | 1 | 7 | 2.2 | COc1ccc(N2CCc3c(-n4ccc(N5CCNS5(=O)=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| 58223435 | 134648 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 461 | 11 | 0 | 9 | 4.2 | COCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCC1 | nan | |||
| CHEMBL3664583 | 134648 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 461 | 11 | 0 | 9 | 4.2 | COCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCC1 | nan | |||
| 22177839 | 71511 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 380 | 6 | 1 | 6 | 4.6 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CCO2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819061 | 71511 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 380 | 6 | 1 | 6 | 4.6 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CCO2 | 10.1016/j.bmc.2011.07.055 | |||
| 46881865 | 14783 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 395 | 8 | 1 | 9 | 2.4 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(C)nc(OC)nc2OC)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1090739 | 14783 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 395 | 8 | 1 | 9 | 2.4 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(C)nc(OC)nc2OC)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| 24768328 | 104482 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 391 | 7 | 3 | 5 | 4.0 | CC[C@@H](CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)NC | 10.1021/jm070579c | |||
| CHEMBL271370 | 104482 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 391 | 7 | 3 | 5 | 4.0 | CC[C@@H](CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)NC | 10.1021/jm070579c | |||
| 56680359 | 72085 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 401 | 9 | 0 | 6 | 5.2 | CCCN(CCC)c1cc(N(CC)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828897 | 72085 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 401 | 9 | 0 | 6 | 5.2 | CCCN(CCC)c1cc(N(CC)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 10180350 | 70181 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 418 | 6 | 0 | 4 | 6.5 | CCCC(CCC)N1CCC2CN(c3ccc(Cl)cc3Cl)c3nc(C)nc1c32 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL179608 | 70181 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 418 | 6 | 0 | 4 | 6.5 | CCCC(CCC)N1CCC2CN(c3ccc(Cl)cc3Cl)c3nc(C)nc1c32 | 10.1016/j.bmcl.2007.06.077 | |||
| 21912361 | 104815 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 331 | 6 | 0 | 3 | 5.8 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(F)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL273068 | 104815 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 331 | 6 | 0 | 3 | 5.8 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(F)cc2C)c1C | 10.1021/jm070578k | |||
| 54580963 | 67430 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 428 | 9 | 0 | 8 | 3.6 | CCCN(CCC)c1nc2c(c(-c3c(OC)cc(OC)cc3OC)cn2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| CHEMBL1760260 | 67430 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 428 | 9 | 0 | 8 | 3.6 | CCCN(CCC)c1nc2c(c(-c3c(OC)cc(OC)cc3OC)cn2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| 57395432 | 76758 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 337 | 5 | 0 | 4 | 5.2 | CCC(CC)c1nc(C)c2nc(-c3ccc(OC)cc3C)c(C)cn12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939578 | 76758 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 337 | 5 | 0 | 4 | 5.2 | CCC(CC)c1nc(C)c2nc(-c3ccc(OC)cc3C)c(C)cn12 | 10.1016/j.bmc.2011.11.015 | |||
| 24768337 | 172794 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 429 | 9 | 1 | 8 | 3.1 | CCCN(CCOC)c1nc(C)nc2c1NC(=O)CN2c1cc(OC)c(OC)cc1C | 10.1021/jm0611410 | |||
| CHEMBL425476 | 172794 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 429 | 9 | 1 | 8 | 3.1 | CCCN(CCOC)c1nc(C)nc2c1NC(=O)CN2c1cc(OC)c(OC)cc1C | 10.1021/jm0611410 | |||
| 11235455 | 182245 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 418 | 5 | 1 | 6 | 3.5 | CCOc1ccc(N2CCc3c(-n4ccc(N5CCNC5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| CHEMBL457710 | 182245 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 418 | 5 | 1 | 6 | 3.5 | CCOc1ccc(N2CCc3c(-n4ccc(N5CCNC5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| 44589349 | 182896 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 367 | 3 | 0 | 7 | 3.3 | Cc1cc(C#N)ccc1N1CCc2c(-n3ccc(-n4cccn4)n3)ccnc21 | 10.1021/jm800743q | |||
| CHEMBL459181 | 182896 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 367 | 3 | 0 | 7 | 3.3 | Cc1cc(C#N)ccc1N1CCc2c(-n3ccc(-n4cccn4)n3)ccnc21 | 10.1021/jm800743q | |||
| 53358606 | 137371 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 386 | 4 | 1 | 4 | 4.1 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2cc3c(n2)CCCC3)CC1 | nan | |||
| CHEMBL3681376 | 137371 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 386 | 4 | 1 | 4 | 4.1 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2cc3c(n2)CCCC3)CC1 | nan | |||
| 58223385 | 134633 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 475 | 13 | 0 | 9 | 4.5 | CCOCc1cc(OC)c(-c2csc3c(N(CCOC)CC4CC4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664568 | 134633 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 475 | 13 | 0 | 9 | 4.5 | CCOCc1cc(OC)c(-c2csc3c(N(CCOC)CC4CC4)c(OC)nn23)c(OC)c1 | nan | |||
| 58223464 | 134640 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 0 | 9 | 5.0 | CCOCc1cc(OC)c(-c2csc3c(N(CC4CCC4)C4CCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664575 | 134640 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 0 | 9 | 5.0 | CCOCc1cc(OC)c(-c2csc3c(N(CC4CCC4)C4CCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| 56663335 | 72079 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 5.7 | CCCc1c(Nc2ccc(OC)cc2Cl)nc2ccnn2c1N(CCC)CCC | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828891 | 72079 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 5.7 | CCCc1c(Nc2ccc(OC)cc2Cl)nc2ccnn2c1N(CCC)CCC | 10.1016/j.bmc.2011.08.055 | |||
| 21912361 | 104815 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 331 | 6 | 0 | 3 | 5.8 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(F)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL273068 | 104815 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 331 | 6 | 0 | 3 | 5.8 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(F)cc2C)c1C | 10.1021/jm070578k | |||
| 11948286 | 163448 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 410 | 5 | 0 | 3 | 7.5 | CCC(CC)c1ccc(Cl)c2nc(Oc3c(C)cc(Cl)cc3Cl)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4069551 | 163448 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 410 | 5 | 0 | 3 | 7.5 | CCC(CC)c1ccc(Cl)c2nc(Oc3c(C)cc(Cl)cc3Cl)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 11201828 | 182731 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 453 | 3 | 1 | 6 | 3.7 | Cc1cc(-n2ccc(N3CCNC3=O)n2)c2c(n1)N(c1ccc(C#N)cc1C(F)(F)F)CC2 | 10.1021/jm800744m | |||
| CHEMBL458810 | 182731 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 453 | 3 | 1 | 6 | 3.7 | Cc1cc(-n2ccc(N3CCNC3=O)n2)c2c(n1)N(c1ccc(C#N)cc1C(F)(F)F)CC2 | 10.1021/jm800744m | |||
| 42618212 | 190871 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 395 | 7 | 0 | 7 | 4.1 | CCCCN(CC)c1nc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL482542 | 190871 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 395 | 7 | 0 | 7 | 4.1 | CCCCN(CC)c1nc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 57786096 | 171874 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 475 | 4 | 0 | 6 | 5.8 | Cc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc(C(OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4227177 | 171874 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 475 | 4 | 0 | 6 | 5.8 | Cc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc(C(OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | |||
| 70686154 | 82362 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 9 | 0 | 7 | 5.5 | CCN(c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12)C1CCOCC1 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2046530 | 82362 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 9 | 0 | 7 | 5.5 | CCN(c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12)C1CCOCC1 | 10.1016/j.bmcl.2012.05.066 | |||
| 11476167 | 196483 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 439 | 4 | 0 | 7 | 3.1 | COc1ccc(N2CCc3c(-n4ccc(N5CCCS5(=O)=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| CHEMBL515503 | 196483 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 439 | 4 | 0 | 7 | 3.1 | COc1ccc(N2CCc3c(-n4ccc(N5CCCS5(=O)=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| 10184943 | 73476 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 490 | 5 | 0 | 4 | 6.6 | CCc1nc2c(n1Cc1ccc(-c3ccccc3)cc1)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL185541 | 73476 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 490 | 5 | 0 | 4 | 6.6 | CCc1nc2c(n1Cc1ccc(-c3ccccc3)cc1)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 58223455 | 131202 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 457 | 9 | 0 | 8 | 4.7 | COc1cc(C)cc(OC)c1-c1csc2c(N(CC3CC3)CC3CCOC3)c(OC)nn12 | nan | |||
| CHEMBL3639634 | 131202 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 457 | 9 | 0 | 8 | 4.7 | COc1cc(C)cc(OC)c1-c1csc2c(N(CC3CC3)CC3CCOC3)c(OC)nn12 | nan | |||
| 58223403 | 134650 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 483 | 10 | 0 | 8 | 5.2 | COc1cc(C2CC2)cc(OC)c1-c1csc2c(N(CC3CC3)CC3CCOC3)c(OC)nn12 | nan | |||
| CHEMBL3664585 | 134650 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 483 | 10 | 0 | 8 | 5.2 | COc1cc(C2CC2)cc(OC)c1-c1csc2c(N(CC3CC3)CC3CCOC3)c(OC)nn12 | nan | |||
| 58223493 | 134669 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 468 | 10 | 0 | 9 | 5.2 | CCCN(c1ccccn1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| CHEMBL3664603 | 134669 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 468 | 10 | 0 | 9 | 5.2 | CCCN(c1ccccn1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| 56683762 | 72274 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 8 | 0 | 7 | 4.2 | CCCN(CCC)c1cc(N(C)c2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830518 | 72274 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 8 | 0 | 7 | 4.2 | CCCN(CCC)c1cc(N(C)c2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 46890979 | 13611 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 352 | 4 | 1 | 5 | 4.3 | Cc1nc(Nc2c(C)cc(Cl)cc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1084025 | 13611 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 352 | 4 | 1 | 5 | 4.3 | Cc1nc(Nc2c(C)cc(Cl)cc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 46891189 | 13660 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 397 | 4 | 1 | 6 | 4.2 | Cc1nc(Nc2cc(C(F)(F)F)c(C#N)cc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1084242 | 13660 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 397 | 4 | 1 | 6 | 4.2 | Cc1nc(Nc2cc(C(F)(F)F)c(C#N)cc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 54586829 | 67428 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 380 | 6 | 0 | 5 | 4.5 | CCCN(CCC)c1nc2c(c(-c3ccc(C)cc3C)c(C)n2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| CHEMBL1760258 | 67428 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 380 | 6 | 0 | 5 | 4.5 | CCCN(CCC)c1nc2c(c(-c3ccc(C)cc3C)c(C)n2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| 21984580 | 84327 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 433 | 8 | 0 | 5 | 5.6 | CCc1nn2c(-c3c(C)cc(C)cc3OC)cccc2c1N(CC1CC1)CC1CCCO1 | 10.1021/jm300259r | |||
| CHEMBL2087560 | 84327 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 433 | 8 | 0 | 5 | 5.6 | CCc1nn2c(-c3c(C)cc(C)cc3OC)cccc2c1N(CC1CC1)CC1CCCO1 | 10.1021/jm300259r | |||
| 60155991 | 84354 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 515 | 12 | 0 | 9 | 4.8 | COCCN(CC1CCOCC1)c1c(SC)nn2c(-c3c(OC)cc(COC)cc3OC)cccc12 | 10.1021/jm300259r | |||
| CHEMBL2087801 | 84354 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 515 | 12 | 0 | 9 | 4.8 | COCCN(CC1CCOCC1)c1c(SC)nn2c(-c3c(OC)cc(COC)cc3OC)cccc12 | 10.1021/jm300259r | |||
| 45273018 | 203306 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 381 | 6 | 0 | 5 | 4.7 | CCN(c1c(Cl)cc(OC)cc1Cl)c1nccn([C@H](C)C2CC2)c1=O | 10.1021/jm900301y | |||
| CHEMBL563618 | 203306 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 381 | 6 | 0 | 5 | 4.7 | CCN(c1c(Cl)cc(OC)cc1Cl)c1nccn([C@H](C)C2CC2)c1=O | 10.1021/jm900301y | |||
| 44589302 | 196567 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 425 | 5 | 0 | 7 | 5.0 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C(F)F)c1 | 10.1021/jm800743q | |||
| CHEMBL516175 | 196567 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 425 | 5 | 0 | 7 | 5.0 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C(F)F)c1 | 10.1021/jm800743q | |||
| 56677029 | 72081 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 429 | 11 | 1 | 6 | 6.1 | CCCCc1c(Nc2ccc(OC)cc2Cl)nc2ccnn2c1N(CCC)CCC | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828893 | 72081 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 429 | 11 | 1 | 6 | 6.1 | CCCCc1c(Nc2ccc(OC)cc2Cl)nc2ccnn2c1N(CCC)CCC | 10.1016/j.bmc.2011.08.055 | |||
| 10379 | 9833 | 39 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1016/j.bmc.2016.11.011 | |||
| 9884366 | 9833 | 39 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL482950 | 9833 | 39 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1016/j.bmc.2016.11.011 | |||
| DB12572 | 9833 | 39 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1016/j.bmc.2016.11.011 | |||
| 24805438 | 104785 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(CC)Oc1nc(C)cc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL272893 | 104785 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(CC)Oc1nc(C)cc(Oc2c(C)cc(C)cc2C)c1C | 10.1021/jm070578k | |||
| 44589221 | 182424 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 375 | 3 | 1 | 7 | 4.1 | Cc1cc(O)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| CHEMBL458115 | 182424 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 375 | 3 | 1 | 7 | 4.1 | Cc1cc(O)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| 58223394 | 134635 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 489 | 14 | 0 | 9 | 4.9 | CCOCc1cc(OC)c(-c2csc3c(N(CCCOC)CC4CC4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664570 | 134635 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 489 | 14 | 0 | 9 | 4.9 | CCOCc1cc(OC)c(-c2csc3c(N(CCCOC)CC4CC4)c(OC)nn23)c(OC)c1 | nan | |||
| 54582098 | 67816 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 9 | 0 | 8 | 2.6 | COCCN(CCCF)c1nc(C)nc2c(-c3ccc(OC)nc3)c(C)nn12 | 10.1016/j.bmcl.2011.02.050 | |||
| CHEMBL1762823 | 67816 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 9 | 0 | 8 | 2.6 | COCCN(CCCF)c1nc(C)nc2c(-c3ccc(OC)nc3)c(C)nn12 | 10.1016/j.bmcl.2011.02.050 | |||
| 10075105 | 84341 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 511 | 11 | 0 | 8 | 5.5 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(SC)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| CHEMBL2087574 | 84341 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 511 | 11 | 0 | 8 | 5.5 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(SC)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| 9970050 | 71514 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 380 | 6 | 1 | 6 | 4.7 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)COC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819064 | 71514 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 380 | 6 | 1 | 6 | 4.7 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)COC2 | 10.1016/j.bmc.2011.07.055 | |||
| 44190055 | 202872 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 347 | 5 | 2 | 5 | 3.5 | Cc1cc(C)c(Nc2nc(Cl)cn([C@@H](CO)C3CC3)c2=O)c(C)c1 | 10.1021/jm900301y | |||
| CHEMBL560823 | 202872 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 347 | 5 | 2 | 5 | 3.5 | Cc1cc(C)c(Nc2nc(Cl)cn([C@@H](CO)C3CC3)c2=O)c(C)c1 | 10.1021/jm900301y | |||
| 53357140 | 137369 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 554 | 7 | 3 | 4 | 7.1 | COc1ccc(-c2c(NC[C@H]3CC[C@H](NC(=O)c4cc(C(F)(F)F)ccc4Cl)CC3)n[nH]c2C)c(Cl)c1 | nan | |||
| CHEMBL3681374 | 137369 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 554 | 7 | 3 | 4 | 7.1 | COc1ccc(-c2c(NC[C@H]3CC[C@H](NC(=O)c4cc(C(F)(F)F)ccc4Cl)CC3)n[nH]c2C)c(Cl)c1 | nan | |||
| 145968888 | 171937 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 491 | 5 | 0 | 7 | 5.5 | COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc([C@H](OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4228089 | 171937 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 491 | 5 | 0 | 7 | 5.5 | COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc([C@H](OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | |||
| 58223459 | 134644 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 475 | 12 | 0 | 9 | 4.5 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC(C)OC)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664579 | 134644 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 475 | 12 | 0 | 9 | 4.5 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC(C)OC)c(OC)nn23)c(OC)c1 | nan | |||
| 58223427 | 134670 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 468 | 10 | 0 | 9 | 5.2 | CCCN(c1cccnc1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| CHEMBL3664604 | 134670 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 468 | 10 | 0 | 9 | 5.2 | CCCN(c1cccnc1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| 44191107 | 201583 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 367 | 5 | 1 | 5 | 4.6 | COc1cc(Cl)c(C)cc1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1021/jm900302q | |||
| CHEMBL538866 | 201583 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 367 | 5 | 1 | 5 | 4.6 | COc1cc(Cl)c(C)cc1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1021/jm900302q | |||
| 57786134 | 171901 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 387 | 4 | 0 | 3 | 6.1 | CCN(CC)c1cccc2nc3n(c12)CCCC3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4227554 | 171901 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 387 | 4 | 0 | 3 | 6.1 | CCN(CC)c1cccc2nc3n(c12)CCCC3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| 44589291 | 182261 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 5 | 1 | 9 | 2.9 | COc1cc(-n2cccn2)ccc1N1CCc2c(-n3ccc(-n4cc[nH]c4=O)n3)cc(C)nc21 | 10.1021/jm800744m | |||
| CHEMBL457742 | 182261 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 5 | 1 | 9 | 2.9 | COc1cc(-n2cccn2)ccc1N1CCc2c(-n3ccc(-n4cc[nH]c4=O)n3)cc(C)nc21 | 10.1021/jm800744m | |||
| 44589330 | 182258 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 398 | 3 | 0 | 6 | 4.5 | N#Cc1ccc(N2CCc3c(-n4ccc(-c5ccccn5)n4)ccnc32)c(Cl)c1 | 10.1021/jm800743q | |||
| CHEMBL457740 | 182258 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 398 | 3 | 0 | 6 | 4.5 | N#Cc1ccc(N2CCc3c(-n4ccc(-c5ccccn5)n4)ccnc32)c(Cl)c1 | 10.1021/jm800743q | |||
| 90654069 | 135593 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 461 | 9 | 2 | 9 | 3.3 | CCc1sc2c(NC(=O)C3(O)CC3)c(OC)nn2c1-c1c(OC)cc(COC)cc1OC | nan | |||
| CHEMBL3669433 | 135593 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 461 | 9 | 2 | 9 | 3.3 | CCc1sc2c(NC(=O)C3(O)CC3)c(OC)nn2c1-c1c(OC)cc(COC)cc1OC | nan | |||
| 10177704 | 71510 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 378 | 6 | 1 | 5 | 5.1 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819060 | 71510 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 378 | 6 | 1 | 5 | 5.1 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 10178898 | 71515 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 396 | 6 | 1 | 6 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CSC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819065 | 71515 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 396 | 6 | 1 | 6 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CSC2 | 10.1016/j.bmc.2011.07.055 | |||
| 10222795 | 71531 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 402 | 5 | 1 | 4 | 6.1 | CCC(CC)Nc1c2c(nc3c(-c4ccc(Cl)cc4Cl)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819082 | 71531 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 402 | 5 | 1 | 4 | 6.1 | CCC(CC)Nc1c2c(nc3c(-c4ccc(Cl)cc4Cl)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 11751039 | 182659 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 440 | 4 | 1 | 7 | 3.3 | Cc1cc(-n2ccc(N3CCNC3=O)n2)c2c(n1)N(c1ccc(-n3cccn3)cc1C)CC2 | 10.1021/jm800744m | |||
| CHEMBL458626 | 182659 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 440 | 4 | 1 | 7 | 3.3 | Cc1cc(-n2ccc(N3CCNC3=O)n2)c2c(n1)N(c1ccc(-n3cccn3)cc1C)CC2 | 10.1021/jm800744m | |||
| 21984783 | 84326 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 433 | 8 | 0 | 5 | 5.4 | CCc1nn2c(-c3c(C)cc(C)cc3OC)cccc2c1N(CC1CC1)CC1CCOC1 | 10.1021/jm300259r | |||
| CHEMBL2087559 | 84326 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 433 | 8 | 0 | 5 | 5.4 | CCc1nn2c(-c3c(C)cc(C)cc3OC)cccc2c1N(CC1CC1)CC1CCOC1 | 10.1021/jm300259r | |||
| 10135080 | 71523 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 391 | 6 | 1 | 5 | 5.2 | CCC(CC)Nc1c2c(nc3c(-c4ccc(N(C)C)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819073 | 71523 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 391 | 6 | 1 | 5 | 5.2 | CCC(CC)Nc1c2c(nc3c(-c4ccc(N(C)C)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 42618205 | 186949 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 353 | 5 | 0 | 6 | 3.9 | CCN(CC)c1nc(C)nc2c(-c3ccc(OC)c(C)c3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL474906 | 186949 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 353 | 5 | 0 | 6 | 3.9 | CCN(CC)c1nc(C)nc2c(-c3ccc(OC)c(C)c3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 54582962 | 67426 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 364 | 2 | 0 | 5 | 3.9 | Cc1cc(C)c(-c2cn(C)c3nc(N4CCCCC4)n(C)c(=O)c23)c(C)c1 | 10.1016/j.bmcl.2011.02.086 | |||
| CHEMBL1760256 | 67426 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 364 | 2 | 0 | 5 | 3.9 | Cc1cc(C)c(-c2cn(C)c3nc(N4CCCCC4)n(C)c(=O)c23)c(C)c1 | 10.1016/j.bmcl.2011.02.086 | |||
| 10296796 | 70535 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 436 | 7 | 0 | 4 | 6.5 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)C(C)N2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL180151 | 70535 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 436 | 7 | 0 | 4 | 6.5 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)C(C)N2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 44589278 | 182244 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 501 | 5 | 0 | 10 | 2.9 | CS(=O)(=O)c1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(S(C)(=O)=O)c1 | 10.1021/jm800743q | |||
| CHEMBL457708 | 182244 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 501 | 5 | 0 | 10 | 2.9 | CS(=O)(=O)c1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(S(C)(=O)=O)c1 | 10.1021/jm800743q | |||
| 58223475 | 134609 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 463 | 11 | 0 | 8 | 5.9 | CCCN(CCC)c1c(C)nn2c(-c3c(OC)cc(COC)cc3OC)c(SC)sc12 | nan | |||
| CHEMBL3664544 | 134609 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 463 | 11 | 0 | 8 | 5.9 | CCCN(CCC)c1c(C)nn2c(-c3c(OC)cc(COC)cc3OC)c(SC)sc12 | nan | |||
| 58223398 | 134651 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 471 | 9 | 0 | 8 | 5.4 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(C4CC4)cc3OC)csc12)C1CCOCC1 | nan | |||
| CHEMBL3664586 | 134651 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 471 | 9 | 0 | 8 | 5.4 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(C4CC4)cc3OC)csc12)C1CCOCC1 | nan | |||
| 46891036 | 14176 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 5 | 1 | 6 | 4.9 | Cc1nc(Nc2c(Cl)cc(OC(F)(F)F)cc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1086511 | 14176 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 5 | 1 | 6 | 4.9 | Cc1nc(Nc2c(Cl)cc(OC(F)(F)F)cc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 44189948 | 202202 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 347 | 6 | 1 | 4 | 5.0 | CCC(CC)Cn1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL552237 | 202202 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 347 | 6 | 1 | 4 | 5.0 | CCC(CC)Cn1cc(Cl)nc(Nc2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| 57786117 | 171899 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 402 | 4 | 0 | 4 | 5.3 | CCN(CC)c1cccc2nc3n(c12)CCC(=O)N3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4227537 | 171899 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 402 | 4 | 0 | 4 | 5.3 | CCN(CC)c1cccc2nc3n(c12)CCC(=O)N3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| 3499 | 8230 | 28 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1016/j.bmcl.2007.06.077 | |||
| 9909468 | 8230 | 28 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL44698 | 8230 | 28 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1016/j.bmcl.2007.06.077 | |||
| 44444314 | 101032 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 395 | 7 | 0 | 4 | 6.3 | CCCC(CCC)n1cc2c3c(nc(C)cc31)N(c1ccc(OC)c(F)c1)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL250182 | 101032 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 395 | 7 | 0 | 4 | 6.3 | CCCC(CCC)n1cc2c3c(nc(C)cc31)N(c1ccc(OC)c(F)c1)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| 44444336 | 101269 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 374 | 5 | 0 | 5 | 4.8 | CCC(COC)n1cc2c3c(nc(C)cc31)N(c1ccc(C#N)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL251551 | 101269 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 374 | 5 | 0 | 5 | 4.8 | CCC(COC)n1cc2c3c(nc(C)cc31)N(c1ccc(C#N)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| 3499 | 8230 | 28 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm800744m | |||
| 9909468 | 8230 | 28 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm800744m | |||
| CHEMBL44698 | 8230 | 28 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm800744m | |||
| 3499 | 8230 | 28 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm800743q | |||
| 9909468 | 8230 | 28 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm800743q | |||
| CHEMBL44698 | 8230 | 28 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm800743q | |||
| 44589328 | 196520 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 444 | 4 | 0 | 8 | 4.5 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C(F)(F)F)n1 | 10.1021/jm800743q | |||
| CHEMBL515843 | 196520 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 444 | 4 | 0 | 8 | 4.5 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C(F)(F)F)n1 | 10.1021/jm800743q | |||
| 21912363 | 104277 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 341 | 7 | 0 | 4 | 5.5 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C=O)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL270343 | 104277 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 341 | 7 | 0 | 4 | 5.5 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C=O)cc2C)c1C | 10.1021/jm070578k | |||
| 21912239 | 104483 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 371 | 7 | 1 | 4 | 5.9 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C(C)(C)O)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL271373 | 104483 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 371 | 7 | 1 | 4 | 5.9 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C(C)(C)O)cc2C)c1C | 10.1021/jm070578k | |||
| 54581053 | 67817 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 389 | 9 | 0 | 9 | 2.0 | COCCN(CCCF)c1nc(C)nc2c(-c3cnc(OC)nc3)c(C)nn12 | 10.1016/j.bmcl.2011.02.050 | |||
| CHEMBL1762824 | 67817 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 389 | 9 | 0 | 9 | 2.0 | COCCN(CCCF)c1nc(C)nc2c(-c3cnc(OC)nc3)c(C)nn12 | 10.1016/j.bmcl.2011.02.050 | |||
| 71451516 | 88298 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 11 | 0 | 7 | 4.9 | CCN(CCOC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160172 | 88298 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 11 | 0 | 7 | 4.9 | CCN(CCOC)c1ccc(OC)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 10376 | 9704 | 4 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 5.5 | CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC | 10.1016/j.bmc.2011.07.055 | |||
| 9801039 | 9704 | 4 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 5.5 | CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819077 | 9704 | 4 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 5.5 | CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC | 10.1016/j.bmc.2011.07.055 | |||
| 42618202 | 196546 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 433 | 6 | 0 | 7 | 4.0 | CCN(CC)c1nc(C)nc2c(-c3cc(OC)c(OC)cc3Br)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL516026 | 196546 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 433 | 6 | 0 | 7 | 4.0 | CCN(CC)c1nc(C)nc2c(-c3cc(OC)c(OC)cc3Br)c(C)nn12 | 10.1021/jm9000242 | |||
| 71455126 | 88764 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 395 | 8 | 1 | 6 | 4.2 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OCF)cc2C)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL2165195 | 88764 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 395 | 8 | 1 | 6 | 4.2 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OCF)cc2C)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| 44190825 | 201925 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 425 | 4 | 1 | 4 | 5.9 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL550215 | 201925 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 425 | 4 | 1 | 4 | 5.9 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 11948286 | 163448 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 410 | 5 | 0 | 3 | 7.5 | CCC(CC)c1ccc(Cl)c2nc(Oc3c(C)cc(Cl)cc3Cl)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4069551 | 163448 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 410 | 5 | 0 | 3 | 7.5 | CCC(CC)c1ccc(Cl)c2nc(Oc3c(C)cc(Cl)cc3Cl)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 11363701 | 74188 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 482 | 6 | 1 | 5 | 6.0 | CCN(Cc1ccco1)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Br | 10.1021/jm049737f | |||
| CHEMBL188858 | 74188 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 482 | 6 | 1 | 5 | 6.0 | CCN(Cc1ccco1)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Br | 10.1021/jm049737f | |||
| 54754516 | 72078 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 401 | 9 | 1 | 6 | 5.3 | CCCN(CCC)c1c(CC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828890 | 72078 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 401 | 9 | 1 | 6 | 5.3 | CCCN(CCC)c1c(CC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 9908904 | 187266 | 4 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm200365y | |||
| CHEMBL474287 | 187266 | 4 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm200365y | |||
| CHEMBL475306 | 187266 | 4 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm200365y | |||
| 57402456 | 76784 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 353 | 4 | 0 | 5 | 4.1 | CCC(C)c1cc(C)n2nc(-c3c(C)cc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939603 | 76784 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 353 | 4 | 0 | 5 | 4.1 | CCC(C)c1cc(C)n2nc(-c3c(C)cc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 24768329 | 92381 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 368 | 7 | 1 | 5 | 4.9 | CCCCN(CC)c1cc(C)nc2c1NCCN2c1ccc(OC)cc1C | 10.1021/jm0611410 | |||
| CHEMBL228227 | 92381 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 368 | 7 | 1 | 5 | 4.9 | CCCCN(CC)c1cc(C)nc2c1NCCN2c1ccc(OC)cc1C | 10.1021/jm0611410 | |||
| 3499 | 8230 | 28 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm9000242 | |||
| 9909468 | 8230 | 28 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm9000242 | |||
| CHEMBL44698 | 8230 | 28 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm9000242 | |||
| 9908904 | 187266 | 4 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL474287 | 187266 | 4 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL475306 | 187266 | 4 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 11181033 | 18546 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 383 | 7 | 1 | 6 | 3.8 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)nc1C | 10.1021/jm049737f | |||
| CHEMBL1181692 | 18546 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 383 | 7 | 1 | 6 | 3.8 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)nc1C | 10.1021/jm049737f | |||
| CHEMBL188861 | 18546 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 383 | 7 | 1 | 6 | 3.8 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)nc1C | 10.1021/jm049737f | |||
| 44591727 | 198250 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 381 | 7 | 0 | 6 | 4.7 | CCCCN(CC)c1nc(C)nc2c(-c3c(C)cc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL519339 | 198250 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 381 | 7 | 0 | 6 | 4.7 | CCCCN(CC)c1nc(C)nc2c(-c3c(C)cc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 56961969 | 88771 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 443 | 9 | 1 | 7 | 3.5 | COCC(COC)n1cc(Br)nc(Nc2c(C)cc(OCF)cc2C)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL2165201 | 88771 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 443 | 9 | 1 | 7 | 3.5 | COCC(COC)n1cc(Br)nc(Nc2c(C)cc(OCF)cc2C)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| 44191186 | 202394 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 414 | 6 | 1 | 6 | 4.7 | C[C@H](C1CC1)n1cc(C#N)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL556089 | 202394 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 414 | 6 | 1 | 6 | 4.7 | C[C@H](C1CC1)n1cc(C#N)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 56683688 | 72088 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 413 | 10 | 0 | 6 | 5.3 | C=CCN(c1cc(N(CCC)CCC)n2nccc2n1)c1ccc(OC)cc1Cl | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828900 | 72088 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 413 | 10 | 0 | 6 | 5.3 | C=CCN(c1cc(N(CCC)CCC)n2nccc2n1)c1ccc(OC)cc1Cl | 10.1016/j.bmc.2011.08.055 | |||
| 57398970 | 76765 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 403 | 7 | 1 | 6 | 4.0 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(CCO)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939585 | 76765 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 403 | 7 | 1 | 6 | 4.0 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(CCO)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 46891493 | 13337 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 434 | 8 | 1 | 7 | 4.2 | COC[C@H](C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1083012 | 13337 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 434 | 8 | 1 | 7 | 4.2 | COC[C@H](C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 9820671 | 195597 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 369 | 6 | 1 | 7 | 3.9 | CC[C@@H](C)Nc1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL506214 | 195597 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 369 | 6 | 1 | 7 | 3.9 | CC[C@@H](C)Nc1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 71580313 | 95213 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 424 | 8 | 1 | 6 | 4.4 | Cc1cc(C#N)cc(Cl)c1Nc1nc(Cl)cn([C@@H](COCCF)C2CC2)c1=O | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL2349564 | 95213 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 424 | 8 | 1 | 6 | 4.4 | Cc1cc(C#N)cc(Cl)c1Nc1nc(Cl)cn([C@@H](COCCF)C2CC2)c1=O | 10.1016/j.bmcl.2013.02.009 | |||
| 57397279 | 76774 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 390 | 6 | 0 | 6 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC(F)F)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939594 | 76774 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 390 | 6 | 0 | 6 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC(F)F)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 10379 | 9833 | 39 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm900025h | |||
| 9884366 | 9833 | 39 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm900025h | |||
| CHEMBL482950 | 9833 | 39 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm900025h | |||
| DB12572 | 9833 | 39 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm900025h | |||
| 42618222 | 186412 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 354 | 6 | 1 | 7 | 3.7 | CCC[C@H](C)Nc1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL474289 | 186412 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 354 | 6 | 1 | 7 | 3.7 | CCC[C@H](C)Nc1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 57395433 | 76763 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 387 | 6 | 0 | 5 | 5.1 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(CC)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939583 | 76763 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 387 | 6 | 0 | 5 | 5.1 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(CC)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 44190341 | 202903 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 373 | 6 | 0 | 4 | 5.3 | CC[C@H](C1CC1)n1cc(Cl)nc(N(CC)c2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL561035 | 202903 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 373 | 6 | 0 | 4 | 5.3 | CC[C@H](C1CC1)n1cc(Cl)nc(N(CC)c2c(C)cc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| 9908904 | 187266 | 4 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL474287 | 187266 | 4 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL475306 | 187266 | 4 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 399 | 9 | 0 | 8 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 56659949 | 72282 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 381 | 6 | 1 | 5 | 6.0 | CCc1cc(Cl)ccc1Nc1nc2ccnn2c2c1ccn2C(CC)CC | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830525 | 72282 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 381 | 6 | 1 | 5 | 6.0 | CCc1cc(Cl)ccc1Nc1nc2ccnn2c2c1ccn2C(CC)CC | 10.1016/j.bmc.2011.08.055 | |||
| 71580427 | 95219 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 346 | 6 | 1 | 6 | 3.2 | COc1nc(C)c(Nc2nc(C)cn([C@@H](CF)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL2349571 | 95219 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 346 | 6 | 1 | 6 | 3.2 | COc1nc(C)c(Nc2nc(C)cn([C@@H](CF)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2013.02.009 | |||
| 58280028 | 146701 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 463 | 10 | 2 | 8 | 4.1 | CCCCNC(=O)OC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3799560 | 146701 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 463 | 10 | 2 | 8 | 4.1 | CCCCNC(=O)OC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1016/j.bmcl.2016.03.067 | |||
| 46881836 | 14516 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 414 | 8 | 1 | 7 | 3.9 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1089038 | 14516 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 414 | 8 | 1 | 7 | 3.9 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cc(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| 44191108 | 203460 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 331 | 4 | 1 | 4 | 4.5 | Cc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1021/jm900302q | |||
| CHEMBL564639 | 203460 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 331 | 4 | 1 | 4 | 4.5 | Cc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1C | 10.1021/jm900302q | |||
| 57400682 | 76777 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 359 | 4 | 0 | 5 | 4.2 | CCC(C)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939597 | 76777 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 359 | 4 | 0 | 5 | 4.2 | CCC(C)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 127046470 | 146396 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 469 | 8 | 1 | 9 | 3.9 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)c3ccncc3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3797551 | 146396 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 469 | 8 | 1 | 9 | 3.9 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)c3ccncc3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 42618234 | 195055 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 368 | 7 | 0 | 7 | 3.7 | CCCCN(CC)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL500013 | 195055 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 368 | 7 | 0 | 7 | 3.7 | CCCCN(CC)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 42618186 | 186775 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 367 | 6 | 0 | 7 | 3.4 | C=CCN(C)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL474699 | 186775 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 367 | 6 | 0 | 7 | 3.4 | C=CCN(C)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 42618203 | 186031 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 493 | 10 | 0 | 9 | 3.3 | COCCN(CCOC)c1nc(C)nc2c(-c3cc(OC)c(OC)cc3Br)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL472874 | 186031 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 493 | 10 | 0 | 9 | 3.3 | COCCN(CCOC)c1nc(C)nc2c(-c3cc(OC)c(OC)cc3Br)c(C)nn12 | 10.1021/jm9000242 | |||
| 58223391 | 134624 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 463 | 13 | 0 | 9 | 4.5 | CCCCN(CCOC)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| CHEMBL3664559 | 134624 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 463 | 13 | 0 | 9 | 4.5 | CCCCN(CCOC)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| 60155710 | 84330 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 463 | 9 | 0 | 6 | 5.5 | CCc1nn2c(-c3c(C)cc(OC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087563 | 84330 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 463 | 9 | 0 | 6 | 5.5 | CCc1nn2c(-c3c(C)cc(OC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| 60155795 | 84338 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 451 | 9 | 0 | 6 | 5.5 | CCCN(CC1CCOCC1)c1c(CC)nn2c(-c3c(OC)cc(C)cc3OC)cccc12 | 10.1021/jm300259r | |||
| CHEMBL2087571 | 84338 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 451 | 9 | 0 | 6 | 5.5 | CCCN(CC1CCOCC1)c1c(CC)nn2c(-c3c(OC)cc(C)cc3OC)cccc12 | 10.1021/jm300259r | |||
| 21912363 | 104277 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 341 | 7 | 0 | 4 | 5.5 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C=O)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL270343 | 104277 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 341 | 7 | 0 | 4 | 5.5 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C=O)cc2C)c1C | 10.1021/jm070578k | |||
| 21912239 | 104483 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 371 | 7 | 1 | 4 | 5.9 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C(C)(C)O)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL271373 | 104483 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 371 | 7 | 1 | 4 | 5.9 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C(C)(C)O)cc2C)c1C | 10.1021/jm070578k | |||
| 53358377 | 131224 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 388 | 5 | 1 | 4 | 4.7 | Cc1cc(C(C)C)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)n1 | nan | |||
| CHEMBL3639802 | 131224 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 388 | 5 | 1 | 4 | 4.7 | Cc1cc(C(C)C)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)n1 | nan | |||
| 11383860 | 73797 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 394 | 7 | 0 | 6 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL187039 | 73797 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 394 | 7 | 0 | 6 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 21984555 | 84324 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 407 | 9 | 0 | 5 | 5.1 | CCc1nn2c(-c3c(C)cc(C)cc3OC)cccc2c1N(CCOC)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087557 | 84324 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 407 | 9 | 0 | 5 | 5.1 | CCc1nn2c(-c3c(C)cc(C)cc3OC)cccc2c1N(CCOC)CC1CC1 | 10.1021/jm300259r | |||
| 71455051 | 88288 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 444 | 9 | 0 | 5 | 6.2 | CCN(CC)c1ccc(C(F)F)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160162 | 88288 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 444 | 9 | 0 | 5 | 6.2 | CCN(CC)c1ccc(C(F)F)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 56670201 | 72086 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 415 | 10 | 0 | 6 | 5.6 | CCCN(CCC)c1cc(N(CCC)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828898 | 72086 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 415 | 10 | 0 | 6 | 5.6 | CCCN(CCC)c1cc(N(CCC)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 56659947 | 72272 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 374 | 7 | 1 | 7 | 4.2 | CCC(CC)Nc1cc(N(C)c2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830516 | 72272 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 374 | 7 | 1 | 7 | 4.2 | CCC(CC)Nc1cc(N(C)c2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 56663414 | 72278 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 401 | 9 | 0 | 6 | 5.2 | CCCN(CCC)c1cc(N(CC)c2ccc(OC)cc2Cl)nc2nccn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830521 | 72278 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 401 | 9 | 0 | 6 | 5.2 | CCCN(CCC)c1cc(N(CC)c2ccc(OC)cc2Cl)nc2nccn12 | 10.1016/j.bmc.2011.08.055 | |||
| 58730488 | 84331 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 479 | 10 | 0 | 7 | 5.2 | CCc1nn2c(-c3c(OC)cc(OC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087564 | 84331 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 479 | 10 | 0 | 7 | 5.2 | CCc1nn2c(-c3c(OC)cc(OC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| 25150449 | 182540 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 401 | 4 | 0 | 7 | 5.0 | COc1ccc(-n2ccc3c(-n4ccc(-c5nccs5)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800743q | |||
| CHEMBL458353 | 182540 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 401 | 4 | 0 | 7 | 5.0 | COc1ccc(-n2ccc3c(-n4ccc(-c5nccs5)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800743q | |||
| 58223397 | 134623 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 457 | 8 | 0 | 8 | 4.8 | COc1cc(C)cc(OC)c1-c1csc2c(N(CC3CC3)C3CCOCC3)c(OC)nn12 | nan | |||
| CHEMBL3664558 | 134623 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 457 | 8 | 0 | 8 | 4.8 | COc1cc(C)cc(OC)c1-c1csc2c(N(CC3CC3)C3CCOCC3)c(OC)nn12 | nan | |||
| 71462615 | 89379 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 11 | 0 | 9 | 4.6 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4CCCO4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| CHEMBL2179182 | 89379 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 11 | 0 | 9 | 4.6 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4CCCO4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| 24768335 | 92267 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 428 | 9 | 1 | 7 | 3.7 | CCCN(CCOC)c1cc(C)nc2c1NC(=O)CN2c1cc(OC)c(OC)cc1C | 10.1021/jm0611410 | |||
| CHEMBL227028 | 92267 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 428 | 9 | 1 | 7 | 3.7 | CCCN(CCOC)c1cc(C)nc2c1NC(=O)CN2c1cc(OC)c(OC)cc1C | 10.1021/jm0611410 | |||
| 10202622 | 130600 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 424 | 7 | 0 | 5 | 4.9 | CCCC(COC)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL362413 | 130600 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 424 | 7 | 0 | 5 | 4.9 | CCCC(COC)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 58223445 | 134621 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 471 | 10 | 0 | 8 | 4.9 | CCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4CCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664556 | 134621 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 471 | 10 | 0 | 8 | 4.9 | CCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4CCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| 58896479 | 183048 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 496 | 6 | 1 | 5 | 8.1 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(CC(C)(C)C)c3ccc(Cl)cc3)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4566348 | 183048 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 496 | 6 | 1 | 5 | 8.1 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(CC(C)(C)C)c3ccc(Cl)cc3)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4595038 | 183048 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 496 | 6 | 1 | 5 | 8.1 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(CC(C)(C)C)c3ccc(Cl)cc3)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| 145959453 | 168934 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 370 | 4 | 1 | 7 | 3.3 | CCN(CC)c1nc(C)nc2c1s/c(=N/N)n2-c1c(C)cc(C)cc1C | 10.1016/j.ejmech.2017.07.016 | |||
| CHEMBL4161963 | 168934 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 370 | 4 | 1 | 7 | 3.3 | CCN(CC)c1nc(C)nc2c1s/c(=N/N)n2-c1c(C)cc(C)cc1C | 10.1016/j.ejmech.2017.07.016 | |||
| 58223386 | 134625 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 10 | 0 | 9 | 4.6 | COCc1cc(OC)c(-c2csc3c(N(CC4CCC4)C4CCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664560 | 134625 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 10 | 0 | 9 | 4.6 | COCc1cc(OC)c(-c2csc3c(N(CC4CCC4)C4CCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| 58223431 | 134636 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 475 | 10 | 0 | 9 | 4.5 | COCc1cc(OC)c(-c2csc3c(N(CC(C)C)C4CCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664571 | 134636 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 475 | 10 | 0 | 9 | 4.5 | COCc1cc(OC)c(-c2csc3c(N(CC(C)C)C4CCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| 58223396 | 134673 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 11 | 0 | 9 | 4.3 | CCCN(CC1C2COCC21)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| CHEMBL3664607 | 134673 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 11 | 0 | 9 | 4.3 | CCCN(CC1C2COCC21)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| 58223461 | 134674 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 499 | 11 | 0 | 9 | 4.3 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4C5COCC54)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664608 | 134674 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 499 | 11 | 0 | 9 | 4.3 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4C5COCC54)c(OC)nn23)c(OC)c1 | nan | |||
| 10182058 | 72032 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 444 | 5 | 0 | 5 | 5.0 | CCc1nc2c(n1Cc1ccc(OC)cc1)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL182779 | 72032 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 444 | 5 | 0 | 5 | 5.0 | CCc1nc2c(n1Cc1ccc(OC)cc1)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 10137474 | 71380 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 428 | 4 | 0 | 4 | 5.3 | CCc1nc2c(n1Cc1ccccc1C)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL181699 | 71380 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 428 | 4 | 0 | 4 | 5.3 | CCc1nc2c(n1Cc1ccccc1C)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 51352159 | 89394 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 485 | 10 | 0 | 8 | 5.2 | COCc1cc(OC)c(-c2csc3c(N(CC4CCOCC4)CC4CC4)c(C)nn23)c(OC)c1 | nan | |||
| CHEMBL2179197 | 89394 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 485 | 10 | 0 | 8 | 5.2 | COCc1cc(OC)c(-c2csc3c(N(CC4CCOCC4)CC4CC4)c(C)nn23)c(OC)c1 | nan | |||
| 71455473 | 89393 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 470 | 9 | 0 | 9 | 4.7 | CCCCN(c1c(OC)nn2c(-c3c(OC)cc(C#N)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| CHEMBL2179196 | 89393 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 470 | 9 | 0 | 9 | 4.7 | CCCCN(c1c(OC)nn2c(-c3c(OC)cc(C#N)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| 51352159 | 89394 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 485 | 10 | 0 | 8 | 5.2 | COCc1cc(OC)c(-c2csc3c(N(CC4CCOCC4)CC4CC4)c(C)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| CHEMBL2179197 | 89394 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 485 | 10 | 0 | 8 | 5.2 | COCc1cc(OC)c(-c2csc3c(N(CC4CCOCC4)CC4CC4)c(C)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| 57786009 | 171714 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 507 | 6 | 0 | 8 | 5.2 | COc1nc(C)nc(OC)c1N1CCCn2c1nc1c(Cl)ccc(C(OC(F)F)C(F)(F)F)c12 | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4224781 | 171714 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 507 | 6 | 0 | 8 | 5.2 | COc1nc(C)nc(OC)c1N1CCCn2c1nc1c(Cl)ccc(C(OC(F)F)C(F)(F)F)c12 | 10.1016/j.bmc.2018.01.020 | |||
| 24768323 | 104826 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 371 | 7 | 0 | 5 | 5.5 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C(=O)OC | 10.1021/jm070578k | |||
| CHEMBL273117 | 104826 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 371 | 7 | 0 | 5 | 5.5 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C(=O)OC | 10.1021/jm070578k | |||
| 70692631 | 82675 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 378 | 7 | 2 | 4 | 5.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)[nH]c12 | 10.1016/j.ejmech.2021.114085 | |||
| CHEMBL2049190 | 82675 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 378 | 7 | 2 | 4 | 5.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)[nH]c12 | 10.1016/j.ejmech.2021.114085 | |||
| 58223442 | 134667 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 503 | 12 | 0 | 9 | 5.4 | CCCCN(c1c(OCC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCOCC1 | nan | |||
| CHEMBL3664601 | 134667 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 503 | 12 | 0 | 9 | 5.4 | CCCCN(c1c(OCC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCOCC1 | nan | |||
| 58223478 | 135591 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 499 | 11 | 0 | 9 | 4.8 | COCc1cc(OC)c(-c2csc3c(N(CC4=CCOCC4)CC4CC4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3669431 | 135591 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 499 | 11 | 0 | 9 | 4.8 | COCc1cc(OC)c(-c2csc3c(N(CC4=CCOCC4)CC4CC4)c(OC)nn23)c(OC)c1 | nan | |||
| 60155888 | 84349 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 481 | 9 | 0 | 7 | 5.7 | COc1cc(C)cc(OC)c1-c1cccc2c(N(CC3CCOCC3)CC3CC3)c(SC)nn12 | 10.1021/jm300259r | |||
| CHEMBL2087796 | 84349 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 481 | 9 | 0 | 7 | 5.7 | COc1cc(C)cc(OC)c1-c1cccc2c(N(CC3CCOCC3)CC3CC3)c(SC)nn12 | 10.1021/jm300259r | |||
| 24768323 | 104826 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 371 | 7 | 0 | 5 | 5.5 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C(=O)OC | 10.1021/jm070578k | |||
| CHEMBL273117 | 104826 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 371 | 7 | 0 | 5 | 5.5 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C(=O)OC | 10.1021/jm070578k | |||
| 70696716 | 82681 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 437 | 11 | 1 | 6 | 6.1 | CCCN(CCC)c1cccc2nc(Nc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2049197 | 82681 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 437 | 11 | 1 | 6 | 6.1 | CCCN(CCC)c1cccc2nc(Nc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | |||
| 58223502 | 89380 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 461 | 12 | 0 | 9 | 4.1 | COCCN(CC1CC1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| CHEMBL2179183 | 89380 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 461 | 12 | 0 | 9 | 4.1 | COCCN(CC1CC1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| 58223374 | 134638 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 475 | 13 | 0 | 9 | 4.5 | CCOCCN(CC1CC1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| CHEMBL3664573 | 134638 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 475 | 13 | 0 | 9 | 4.5 | CCOCCN(CC1CC1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| 58223416 | 134659 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 485 | 11 | 0 | 8 | 5.8 | COCCCN(c1c(OC)nn2c(-c3c(OC)cc(C4CC4)cc3OC)csc12)C1CCCC1 | nan | |||
| CHEMBL3664593 | 134659 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 485 | 11 | 0 | 8 | 5.8 | COCCCN(c1c(OC)nn2c(-c3c(OC)cc(C4CC4)cc3OC)csc12)C1CCCC1 | nan | |||
| 71455472 | 89378 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 487 | 11 | 0 | 9 | 4.5 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4CCOC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| CHEMBL2179181 | 89378 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 487 | 11 | 0 | 9 | 4.5 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4CCOC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| 58223502 | 89380 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 461 | 12 | 0 | 9 | 4.1 | COCCN(CC1CC1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | 10.1021/jm300864p | |||
| CHEMBL2179183 | 89380 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 461 | 12 | 0 | 9 | 4.1 | COCCN(CC1CC1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | 10.1021/jm300864p | |||
| 137656239 | 165309 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 4.9 | CCN(CCO)c1ccc(Br)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4091442 | 165309 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 466 | 7 | 2 | 6 | 4.9 | CCN(CCO)c1ccc(Br)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 44156254 | 171750 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 476 | 5 | 0 | 6 | 5.8 | COc1ccc(N2CCCn3c2nc2c(Cl)ccc(C(OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4225373 | 171750 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 476 | 5 | 0 | 6 | 5.8 | COc1ccc(N2CCCn3c2nc2c(Cl)ccc(C(OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | |||
| 57786307 | 172003 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 475 | 5 | 0 | 5 | 6.4 | COc1ccc(N2CCCn3c2nc2c(Cl)ccc(C(OC(F)F)C(F)(F)F)c23)c(C)c1 | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4229125 | 172003 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 475 | 5 | 0 | 5 | 6.4 | COc1ccc(N2CCCn3c2nc2c(Cl)ccc(C(OC(F)F)C(F)(F)F)c23)c(C)c1 | 10.1016/j.bmc.2018.01.020 | |||
| 58223379 | 134626 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 477 | 9 | 0 | 8 | 5.0 | COc1cc(Cl)cc(OC)c1-c1csc2c(N(CC3CC3)CC3CCOC3)c(OC)nn12 | nan | |||
| CHEMBL3664561 | 134626 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 477 | 9 | 0 | 8 | 5.0 | COc1cc(Cl)cc(OC)c1-c1csc2c(N(CC3CC3)CC3CCOC3)c(OC)nn12 | nan | |||
| 9827578 | 84336 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 507 | 12 | 0 | 7 | 5.8 | CCOCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(CC)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| CHEMBL2087569 | 84336 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 507 | 12 | 0 | 7 | 5.8 | CCOCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(CC)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| 22177864 | 71527 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 410 | 7 | 1 | 6 | 5.5 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4SC)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819078 | 71527 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 410 | 7 | 1 | 6 | 5.5 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4SC)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 56665181 | 71534 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 5.6 | CCC(CC)Nc1c(C)c(C)nc2c(-c3ccc(OC)cc3Cl)c(C)nn12 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819085 | 71534 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 5.6 | CCC(CC)Nc1c(C)c(C)nc2c(-c3ccc(OC)cc3Cl)c(C)nn12 | 10.1016/j.bmc.2011.07.055 | |||
| 53357923 | 137391 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 461 | 5 | 1 | 3 | 6.1 | CCc1nn(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c(C)c1Cl | nan | |||
| CHEMBL3681396 | 137391 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 461 | 5 | 1 | 3 | 6.1 | CCc1nn(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)c(C)c1Cl | nan | |||
| 44392688 | 73089 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL184930 | 73089 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 11237255 | 19026 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 380 | 7 | 1 | 4 | 5.2 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1 | 10.1021/jm049737f | |||
| CHEMBL1184638 | 19026 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 380 | 7 | 1 | 4 | 5.2 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1 | 10.1021/jm049737f | |||
| CHEMBL361296 | 19026 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 380 | 7 | 1 | 4 | 5.2 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1 | 10.1021/jm049737f | |||
| 10112758 | 71518 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 418 | 7 | 1 | 5 | 6.1 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C4CCC4)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819068 | 71518 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 418 | 7 | 1 | 5 | 6.1 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C4CCC4)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 71580315 | 95215 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 444 | 8 | 1 | 6 | 4.8 | N#Cc1cc(Cl)c(Nc2nc(Cl)cn([C@@H](COCCF)C3CC3)c2=O)c(Cl)c1 | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL2349566 | 95215 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 444 | 8 | 1 | 6 | 4.8 | N#Cc1cc(Cl)c(Nc2nc(Cl)cn([C@@H](COCCF)C3CC3)c2=O)c(Cl)c1 | 10.1016/j.bmcl.2013.02.009 | |||
| 56961966 | 88766 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 421 | 8 | 1 | 7 | 3.8 | COCC(COC)n1cc(Cl)nc(Nc2c(Cl)cc(OC)cc2Cl)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL2165197 | 88766 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 421 | 8 | 1 | 7 | 3.8 | COCC(COC)n1cc(Cl)nc(Nc2c(Cl)cc(OC)cc2Cl)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| 57400681 | 76775 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 339 | 4 | 0 | 5 | 3.8 | CCC(C)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939595 | 76775 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 339 | 4 | 0 | 5 | 3.8 | CCC(C)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 46891154 | 14112 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 328 | 5 | 1 | 6 | 3.3 | COc1cc(C)c(Nc2nc(C)nn(C(C)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1086233 | 14112 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 328 | 5 | 1 | 6 | 3.3 | COc1cc(C)c(Nc2nc(C)nn(C(C)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2010.04.121 | |||
| 42618177 | 191134 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 383 | 7 | 1 | 7 | 4.3 | CCC(CC)Nc1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL484408 | 191134 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 383 | 7 | 1 | 7 | 4.3 | CCC(CC)Nc1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 3496 | 7963 | 42 | None | -1 | 2 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm200365y | |||
| 9862166 | 7963 | 42 | None | -1 | 2 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm200365y | |||
| CHEMBL270948 | 7963 | 42 | None | -1 | 2 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm200365y | |||
| 42618224 | 186055 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 368 | 7 | 1 | 7 | 4.1 | CCCCC(C)Nc1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL473070 | 186055 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 368 | 7 | 1 | 7 | 4.1 | CCCCC(C)Nc1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 3496 | 7963 | 42 | None | -1 | 2 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | |||
| 9862166 | 7963 | 42 | None | -1 | 2 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | |||
| CHEMBL270948 | 7963 | 42 | None | -1 | 2 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | |||
| 3496 | 7963 | 42 | None | -1 | 2 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | |||
| 9862166 | 7963 | 42 | None | -1 | 2 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | |||
| CHEMBL270948 | 7963 | 42 | None | -1 | 2 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 326 | 6 | 1 | 3 | 6.0 | CCC(Nc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | |||
| 127047521 | 146797 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 469 | 8 | 1 | 9 | 3.9 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)c3cccnc3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3800125 | 146797 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 469 | 8 | 1 | 9 | 3.9 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)c3cccnc3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 25114821 | 76772 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 390 | 6 | 0 | 6 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3cnc(OC(F)F)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939592 | 76772 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 390 | 6 | 0 | 6 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3cnc(OC(F)F)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 127047518 | 146363 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 406 | 7 | 1 | 8 | 3.2 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(C)=O)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3797368 | 146363 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 406 | 7 | 1 | 8 | 3.2 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(C)=O)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 56961968 | 88767 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.1 | COCC(COC)n1cc(Cl)nc(Nc2c(Cl)cc(OCF)cc2Cl)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL2165198 | 88767 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.1 | COCC(COC)n1cc(Cl)nc(Nc2c(Cl)cc(OCF)cc2Cl)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| 9841231 | 104509 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 347 | 6 | 0 | 3 | 6.3 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL271546 | 104509 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 347 | 6 | 0 | 3 | 6.3 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C | 10.1021/jm070578k | |||
| 54584993 | 67812 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 388 | 8 | 0 | 8 | 2.5 | COCCN(CCF)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1016/j.bmcl.2011.02.050 | |||
| CHEMBL1762819 | 67812 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 388 | 8 | 0 | 8 | 2.5 | COCCN(CCF)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1016/j.bmcl.2011.02.050 | |||
| 9841231 | 104509 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 347 | 6 | 0 | 3 | 6.3 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL271546 | 104509 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 347 | 6 | 0 | 3 | 6.3 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C | 10.1021/jm070578k | |||
| 3495 | 7958 | 28 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm960861b | |||
| 5311055 | 7958 | 28 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm960861b | |||
| CHEMBL9946 | 7958 | 28 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm960861b | |||
| 44190559 | 202933 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 378 | 5 | 1 | 6 | 3.4 | C#Cc1cn([C@H](C)C2CC2)c(=O)c(Nc2ccc(OC)nc2C(F)(F)F)n1 | 10.1021/jm900301y | |||
| CHEMBL561225 | 202933 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 378 | 5 | 1 | 6 | 3.4 | C#Cc1cn([C@H](C)C2CC2)c(=O)c(Nc2ccc(OC)nc2C(F)(F)F)n1 | 10.1021/jm900301y | |||
| 21912379 | 162485 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 390 | 6 | 1 | 3 | 6.5 | CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(Br)cc2C)c1C | 10.1021/jm070579c | |||
| CHEMBL405198 | 162485 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 390 | 6 | 1 | 3 | 6.5 | CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(Br)cc2C)c1C | 10.1021/jm070579c | |||
| 21912379 | 162485 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 390 | 6 | 1 | 3 | 6.5 | CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(Br)cc2C)c1C | 10.1021/jm070579c | |||
| CHEMBL405198 | 162485 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 390 | 6 | 1 | 3 | 6.5 | CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(Br)cc2C)c1C | 10.1021/jm070579c | |||
| 57397278 | 76767 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 379 | 6 | 0 | 5 | 5.0 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C3CC3)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939587 | 76767 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 379 | 6 | 0 | 5 | 5.0 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C3CC3)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 42618226 | 186083 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 368 | 7 | 0 | 7 | 3.7 | CCCN(CCC)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL473277 | 186083 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 368 | 7 | 0 | 7 | 3.7 | CCCN(CCC)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 54584992 | 67811 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 358 | 6 | 0 | 7 | 2.9 | CCN(CCF)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1016/j.bmcl.2011.02.050 | |||
| CHEMBL1762818 | 67811 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 358 | 6 | 0 | 7 | 2.9 | CCN(CCF)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1016/j.bmcl.2011.02.050 | |||
| 24768343 | 149576 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 394 | 7 | 1 | 5 | 4.6 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)=O)cc1C | 10.1021/jm0611410 | |||
| CHEMBL389288 | 149576 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 394 | 7 | 1 | 5 | 4.6 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)=O)cc1C | 10.1021/jm0611410 | |||
| 44190241 | 202873 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 351 | 6 | 1 | 6 | 3.5 | COC[C@H](C)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL560827 | 202873 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 351 | 6 | 1 | 6 | 3.5 | COC[C@H](C)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| 25115057 | 76768 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 399 | 6 | 0 | 5 | 5.4 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C3CC3)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939588 | 76768 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 399 | 6 | 0 | 5 | 5.4 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C3CC3)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 10255153 | 84334 | 8 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 493 | 11 | 0 | 7 | 5.4 | CCc1nn2c(-c3c(OC)cc(COC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087549 | 84334 | 8 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 493 | 11 | 0 | 7 | 5.4 | CCc1nn2c(-c3c(OC)cc(COC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| CHEMBL2087567 | 84334 | 8 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 493 | 11 | 0 | 7 | 5.4 | CCc1nn2c(-c3c(OC)cc(COC)cc3OC)cccc2c1N(CC1CCOCC1)CC1CC1 | 10.1021/jm300259r | |||
| 71453734 | 89376 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 501 | 11 | 0 | 9 | 4.9 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4CCCOC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| CHEMBL2179179 | 89376 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 501 | 11 | 0 | 9 | 4.9 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4CCCOC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| 57786200 | 171999 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 499 | 4 | 0 | 4 | 7.4 | FC(F)OC(c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl)C(F)(F)F | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4229070 | 171999 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 499 | 4 | 0 | 4 | 7.4 | FC(F)OC(c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl)C(F)(F)F | 10.1016/j.bmc.2018.01.020 | |||
| 58896503 | 183321 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 484 | 8 | 1 | 6 | 6.7 | COCCN(c1ccc(Cl)cc1)c1cccc2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4540030 | 183321 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 484 | 8 | 1 | 6 | 6.7 | COCCN(c1ccc(Cl)cc1)c1cccc2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4597163 | 183321 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 484 | 8 | 1 | 6 | 6.7 | COCCN(c1ccc(Cl)cc1)c1cccc2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.08.005 | |||
| 10113560 | 72096 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 430 | 8 | 0 | 4 | 6.5 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(C(C)C)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL182914 | 72096 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 430 | 8 | 0 | 4 | 6.5 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(C(C)C)cc1Cl | 10.1021/jm049787k | |||
| 3520 | 10041 | 54 | None | 1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm040058e | |||
| 9821250 | 10041 | 54 | None | 1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm040058e | |||
| CHEMBL309138 | 10041 | 54 | None | 1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm040058e | |||
| 11372928 | 177049 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 398 | 7 | 0 | 6 | 4.5 | CCCN(CCC)c1c(F)c(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL444614 | 177049 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 398 | 7 | 0 | 6 | 4.5 | CCCN(CCC)c1c(F)c(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 9865060 | 70317 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 387 | 6 | 0 | 5 | 5.8 | CCCC(CCC)n1cc2c3c(nc(C)nc31)N(c1ccc(C#N)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL180025 | 70317 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 387 | 6 | 0 | 5 | 5.8 | CCCC(CCC)n1cc2c3c(nc(C)nc31)N(c1ccc(C#N)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| 44444318 | 101185 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 367 | 5 | 0 | 4 | 5.5 | CCC(CC)n1cc2c3c(nc(C)cc31)N(c1ccc(OC)c(F)c1)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL250996 | 101185 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 367 | 5 | 0 | 4 | 5.5 | CCC(CC)n1cc2c3c(nc(C)cc31)N(c1ccc(OC)c(F)c1)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| 11475476 | 181771 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 413 | 4 | 1 | 6 | 3.2 | CCc1cc(C#N)ccc1N1CCc2c(-n3ccc(N4CCNC4=O)n3)cc(C)nc21 | 10.1021/jm800744m | |||
| CHEMBL456660 | 181771 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 413 | 4 | 1 | 6 | 3.2 | CCc1cc(C#N)ccc1N1CCc2c(-n3ccc(N4CCNC4=O)n3)cc(C)nc21 | 10.1021/jm800744m | |||
| 58223494 | 134611 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 501 | 11 | 0 | 9 | 4.8 | COCc1cc(OC)c(-c2c(C)sc3c(N(CC4CC4)CC4CCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664546 | 134611 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 501 | 11 | 0 | 9 | 4.8 | COCc1cc(OC)c(-c2c(C)sc3c(N(CC4CC4)CC4CCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| 58223415 | 134616 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 461 | 10 | 0 | 9 | 4.2 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCOC1 | nan | |||
| CHEMBL3664551 | 134616 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 461 | 10 | 0 | 9 | 4.2 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCOC1 | nan | |||
| 58223501 | 134668 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 489 | 12 | 0 | 9 | 4.9 | CCCN(CC1CCOC1)c1c(OCC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| CHEMBL3664602 | 134668 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 489 | 12 | 0 | 9 | 4.9 | CCCN(CC1CCOC1)c1c(OCC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| 58801661 | 84340 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 495 | 11 | 0 | 8 | 4.8 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| CHEMBL2087573 | 84340 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 495 | 11 | 0 | 8 | 4.8 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| 46890981 | 13613 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 358 | 7 | 1 | 7 | 2.9 | COCC(C1CC1)n1nc(C)nc(Nc2c(C)cc(OC)cc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1084027 | 13613 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 358 | 7 | 1 | 7 | 2.9 | COCC(C1CC1)n1nc(C)nc(Nc2c(C)cc(OC)cc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 11361847 | 70672 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 408 | 5 | 0 | 4 | 5.5 | CCc1nc2c(n1C(CC)C(C)C)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL180491 | 70672 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 408 | 5 | 0 | 4 | 5.5 | CCc1nc2c(n1C(CC)C(C)C)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 58223387 | 134619 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 501 | 11 | 0 | 9 | 5.0 | COc1cc(C(C)OC)cc(OC)c1-c1csc2c(N(CC3CC3)CC3CCOC3)c(OC)nn12 | nan | |||
| CHEMBL3664554 | 134619 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 501 | 11 | 0 | 9 | 5.0 | COc1cc(C(C)OC)cc(OC)c1-c1csc2c(N(CC3CC3)CC3CCOC3)c(OC)nn12 | nan | |||
| 58223495 | 134657 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 473 | 9 | 0 | 9 | 4.4 | COCc1cc(OC)c(-c2csc3c(N(C4CCC4)C4CCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664591 | 134657 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 473 | 9 | 0 | 9 | 4.4 | COCc1cc(OC)c(-c2csc3c(N(C4CCC4)C4CCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| 58223451 | 134664 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 456 | 9 | 0 | 9 | 4.4 | COCCN(c1c(OC)nn2c(-c3c(OC)cc(C#N)cc3OC)csc12)C1CCCC1 | nan | |||
| CHEMBL3664598 | 134664 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 456 | 9 | 0 | 9 | 4.4 | COCCN(c1c(OC)nn2c(-c3c(OC)cc(C#N)cc3OC)csc12)C1CCCC1 | nan | |||
| 58223407 | 134672 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 480 | 10 | 0 | 9 | 5.2 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)c4cccnc4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664606 | 134672 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 480 | 10 | 0 | 9 | 5.2 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)c4cccnc4)c(OC)nn23)c(OC)c1 | nan | |||
| 60155540 | 84347 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 490 | 10 | 0 | 8 | 4.7 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(C#N)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| CHEMBL2087794 | 84347 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 490 | 10 | 0 | 8 | 4.7 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4CC4)c(C#N)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| 44237814 | 89385 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 489 | 11 | 0 | 9 | 5.0 | CCCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| CHEMBL2179188 | 89385 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 489 | 11 | 0 | 9 | 5.0 | CCCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| 155553483 | 180970 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 508 | 7 | 1 | 6 | 7.0 | COc1cccc(N(c2cccc3nc(Nc4c(C)cc(Br)cc4OC)n(C)c23)C(C)C)c1 | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4547748 | 180970 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 508 | 7 | 1 | 6 | 7.0 | COc1cccc(N(c2cccc3nc(Nc4c(C)cc(Br)cc4OC)n(C)c23)C(C)C)c1 | 10.1016/j.bmc.2016.08.005 | |||
| 10157505 | 130633 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 394 | 5 | 0 | 4 | 5.3 | CCCC(C)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL362601 | 130633 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 394 | 5 | 0 | 4 | 5.3 | CCCC(C)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 58223477 | 134637 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 482 | 11 | 0 | 9 | 5.0 | CCCN(Cc1ccncc1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| CHEMBL3664572 | 134637 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 482 | 11 | 0 | 9 | 5.0 | CCCN(Cc1ccncc1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| 58223420 | 134671 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 486 | 11 | 0 | 9 | 5.1 | COCc1cc(OC)c(-c2csc3c(N(CCCF)c4cccnc4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664605 | 134671 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 486 | 11 | 0 | 9 | 5.1 | COCc1cc(OC)c(-c2csc3c(N(CCCF)c4cccnc4)c(OC)nn23)c(OC)c1 | nan | |||
| 71580428 | 95220 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 397 | 8 | 1 | 8 | 3.1 | COc1nc(C)c(Nc2nc(Cl)cn(C(CCF)C3CC3)c2=O)c(OC)n1 | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL2349572 | 95220 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 397 | 8 | 1 | 8 | 3.1 | COc1nc(C)c(Nc2nc(Cl)cn(C(CCF)C3CC3)c2=O)c(OC)n1 | 10.1016/j.bmcl.2013.02.009 | |||
| 137635682 | 162779 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 5.3 | CCN(CC(C)O)c1ccc(Br)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4061900 | 162779 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 480 | 7 | 2 | 6 | 5.3 | CCN(CC(C)O)c1ccc(Br)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 155565844 | 182396 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 535 | 7 | 2 | 6 | 6.3 | CNC(=O)c1cccc(N(c2cccc3nc(Nc4c(C)cc(Br)cc4OC)n(C)c23)C(C)C)c1 | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4580457 | 182396 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 535 | 7 | 2 | 6 | 6.3 | CNC(=O)c1cccc(N(c2cccc3nc(Nc4c(C)cc(Br)cc4OC)n(C)c23)C(C)C)c1 | 10.1016/j.bmc.2016.08.005 | |||
| 44589203 | 182736 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 389 | 4 | 0 | 7 | 4.4 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C)c1 | 10.1021/jm800743q | |||
| CHEMBL458825 | 182736 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 389 | 4 | 0 | 7 | 4.4 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C)c1 | 10.1021/jm800743q | |||
| 90654667 | 116849 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 386 | 9 | 1 | 5 | 6.2 | CCCN(CCC)c1nc(C)nc(Nc2c(C)cc(C)cc2C)c1SCC | 10.1016/j.ejmech.2014.03.040 | |||
| CHEMBL3235703 | 116849 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 386 | 9 | 1 | 5 | 6.2 | CCCN(CCC)c1nc(C)nc(Nc2c(C)cc(C)cc2C)c1SCC | 10.1016/j.ejmech.2014.03.040 | |||
| 10432407 | 73091 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 7 | 0 | 4 | 6.1 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL184938 | 73091 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 7 | 0 | 4 | 6.1 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 10271870 | 130211 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 392 | 4 | 0 | 4 | 4.9 | CCc1nc2c(n1C(C)C1CC1)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL361745 | 130211 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 392 | 4 | 0 | 4 | 4.9 | CCc1nc2c(n1C(C)C1CC1)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 10112643 | 73126 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 416 | 6 | 0 | 4 | 6.0 | CCc1nc2c(n1C(CC)C(C)C)C(=O)N(C)CN2c1ccc(C(C)C)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL185103 | 73126 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 416 | 6 | 0 | 4 | 6.0 | CCc1nc2c(n1C(CC)C(C)C)C(=O)N(C)CN2c1ccc(C(C)C)cc1Cl | 10.1021/jm049787k | |||
| 58896411 | 182984 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 464 | 7 | 1 | 6 | 6.8 | COc1ccc(N(c2cccc3nc(Nc4c(C)cc(Cl)cc4OC)n(C)c23)C(C)C)cc1 | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4593848 | 182984 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 464 | 7 | 1 | 6 | 6.8 | COc1ccc(N(c2cccc3nc(Nc4c(C)cc(Cl)cc4OC)n(C)c23)C(C)C)cc1 | 10.1016/j.bmc.2016.08.005 | |||
| 58223488 | 134615 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 473 | 10 | 0 | 9 | 4.2 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)C4CCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664550 | 134615 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 473 | 10 | 0 | 9 | 4.2 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)C4CCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| 58223480 | 134618 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 445 | 8 | 0 | 8 | 4.8 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(C)cc3OC)csc12)C1CCOCC1 | nan | |||
| CHEMBL3664553 | 134618 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 445 | 8 | 0 | 8 | 4.8 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(C)cc3OC)csc12)C1CCOCC1 | nan | |||
| 11374063 | 182893 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 440 | 5 | 1 | 6 | 3.7 | COc1ccc(N2CCc3c(-n4ccc(N5CCNC5=O)n4)cc(C)nc32)c(C(F)F)c1 | 10.1021/jm800744m | |||
| CHEMBL459173 | 182893 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 440 | 5 | 1 | 6 | 3.7 | COc1ccc(N2CCc3c(-n4ccc(N5CCNC5=O)n4)cc(C)nc32)c(C(F)F)c1 | 10.1021/jm800744m | |||
| 44589238 | 183791 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 409 | 4 | 0 | 7 | 4.7 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(Cl)c1 | 10.1021/jm800743q | |||
| CHEMBL462789 | 183791 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 409 | 4 | 0 | 7 | 4.7 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(Cl)c1 | 10.1021/jm800743q | |||
| 70692630 | 82673 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 376 | 7 | 1 | 4 | 6.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)nc12 | 10.1016/j.ejmech.2021.114085 | |||
| CHEMBL2049188 | 82673 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 376 | 7 | 1 | 4 | 6.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)nc12 | 10.1016/j.ejmech.2021.114085 | |||
| 58223497 | 134628 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 475 | 13 | 0 | 9 | 4.5 | COCCCN(CC1CC1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| CHEMBL3664563 | 134628 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 475 | 13 | 0 | 9 | 4.5 | COCCCN(CC1CC1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| 58223377 | 134632 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 463 | 13 | 0 | 9 | 4.5 | CCCN(CCCOC)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| CHEMBL3664567 | 134632 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 463 | 13 | 0 | 9 | 4.5 | CCCN(CCCOC)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| 21984746 | 84323 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 365 | 8 | 0 | 4 | 5.5 | CCCN(CCC)c1c(CC)nn2c(-c3ccc(OC)cc3C)cccc12 | 10.1021/jm300259r | |||
| CHEMBL2087556 | 84323 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 365 | 8 | 0 | 4 | 5.5 | CCCN(CCC)c1c(CC)nn2c(-c3ccc(OC)cc3C)cccc12 | 10.1021/jm300259r | |||
| 24768341 | 92379 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 378 | 6 | 1 | 6 | 3.7 | CCCCN(CC)c1nc(C)nc2c1NC(=O)CN2c1ccc(C#N)cc1C | 10.1021/jm0611410 | |||
| CHEMBL228223 | 92379 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 378 | 6 | 1 | 6 | 3.7 | CCCCN(CC)c1nc(C)nc2c1NC(=O)CN2c1ccc(C#N)cc1C | 10.1021/jm0611410 | |||
| 58223474 | 134661 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 500 | 12 | 0 | 9 | 5.0 | COCc1cc(OC)c(-c2csc3c(N(CCCF)Cc4cccnc4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664595 | 134661 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 500 | 12 | 0 | 9 | 5.0 | COCc1cc(OC)c(-c2csc3c(N(CCCF)Cc4cccnc4)c(OC)nn23)c(OC)c1 | nan | |||
| 42618210 | 186590 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 367 | 5 | 0 | 7 | 3.3 | CCN(CC)c1nc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL474493 | 186590 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 367 | 5 | 0 | 7 | 3.3 | CCN(CC)c1nc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 145969226 | 171776 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 491 | 5 | 0 | 7 | 5.5 | COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc([C@@H](OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4225709 | 171776 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 491 | 5 | 0 | 7 | 5.5 | COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc([C@@H](OC(F)F)C(F)(F)F)c23)c(C)n1 | 10.1016/j.bmc.2018.01.020 | |||
| 44589115 | 182247 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 458 | 4 | 0 | 8 | 5.0 | O=[N+]([O-])c1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C(F)(F)F)c1 | 10.1021/jm800743q | |||
| CHEMBL457714 | 182247 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 458 | 4 | 0 | 8 | 5.0 | O=[N+]([O-])c1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C(F)(F)F)c1 | 10.1021/jm800743q | |||
| 155520133 | 180019 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 492 | 8 | 1 | 6 | 7.6 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(c3cccc(OC(C)C)c3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4524490 | 180019 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 492 | 8 | 1 | 6 | 7.6 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(c3cccc(OC(C)C)c3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| 90654668 | 116850 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 418 | 11 | 1 | 7 | 4.7 | CCSc1c(Nc2c(C)cc(C)cc2C)nc(C)nc1N(CCOC)CCOC | 10.1016/j.ejmech.2014.03.040 | |||
| CHEMBL3235705 | 116850 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 418 | 11 | 1 | 7 | 4.7 | CCSc1c(Nc2c(C)cc(C)cc2C)nc(C)nc1N(CCOC)CCOC | 10.1016/j.ejmech.2014.03.040 | |||
| 58223491 | 134642 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 13 | 0 | 9 | 4.9 | COCc1cc(OC)c(-c2csc3c(N(CCOC(C)C)CC4CC4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664577 | 134642 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 13 | 0 | 9 | 4.9 | COCc1cc(OC)c(-c2csc3c(N(CCOC(C)C)CC4CC4)c(OC)nn23)c(OC)c1 | nan | |||
| 22177860 | 71519 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 6 | 1 | 5 | 5.8 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C(F)(F)F)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819069 | 71519 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 6 | 1 | 5 | 5.8 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C(F)(F)F)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 67364197 | 137381 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 519 | 5 | 1 | 5 | 6.2 | Cc1cc(-c2ccc3c(c2)OCO3)nn1C[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | |||
| CHEMBL3681386 | 137381 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 519 | 5 | 1 | 5 | 6.2 | Cc1cc(-c2ccc3c(c2)OCO3)nn1C[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | |||
| 56678852 | 71533 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 372 | 6 | 1 | 5 | 5.3 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3Cl)c(C)nn12 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819084 | 71533 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 372 | 6 | 1 | 5 | 5.3 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3Cl)c(C)nn12 | 10.1016/j.bmc.2011.07.055 | |||
| 10112776 | 172993 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 418 | 5 | 0 | 4 | 5.3 | CCc1nc2c(n1C(C1CC1)C1CC1)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL426607 | 172993 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 418 | 5 | 0 | 4 | 5.3 | CCc1nc2c(n1C(C1CC1)C1CC1)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 42618201 | 186030 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 447 | 7 | 1 | 7 | 4.8 | CCC(CC)Nc1nc(C)nc2c(-c3cc(OC)c(OC)cc3Br)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL472873 | 186030 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 447 | 7 | 1 | 7 | 4.8 | CCC(CC)Nc1nc(C)nc2c(-c3cc(OC)c(OC)cc3Br)c(C)nn12 | 10.1021/jm9000242 | |||
| 42618167 | 187432 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 339 | 5 | 0 | 6 | 3.6 | CCN(CC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL475505 | 187432 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 339 | 5 | 0 | 6 | 3.6 | CCN(CC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 10379 | 9833 | 39 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1124/dmd.111.043596 | |||
| 9884366 | 9833 | 39 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1124/dmd.111.043596 | |||
| CHEMBL482950 | 9833 | 39 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1124/dmd.111.043596 | |||
| DB12572 | 9833 | 39 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1124/dmd.111.043596 | |||
| 11552261 | 72284 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 361 | 5 | 1 | 5 | 5.7 | CCC(CC)n1ccc2c(Nc3c(C)cc(C)cc3C)nc3ccnn3c21 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830527 | 72284 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 361 | 5 | 1 | 5 | 5.7 | CCC(CC)n1ccc2c(Nc3c(C)cc(C)cc3C)nc3ccnn3c21 | 10.1016/j.bmc.2011.08.055 | |||
| 10379 | 9833 | 39 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm200365y | |||
| 9884366 | 9833 | 39 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm200365y | |||
| CHEMBL482950 | 9833 | 39 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm200365y | |||
| DB12572 | 9833 | 39 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm200365y | |||
| 10379 | 9833 | 39 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm900025h | |||
| 9884366 | 9833 | 39 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm900025h | |||
| CHEMBL482950 | 9833 | 39 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm900025h | |||
| DB12572 | 9833 | 39 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 10.1021/jm900025h | |||
| 46891032 | 13441 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 398 | 7 | 1 | 7 | 3.6 | COCC(C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1083420 | 13441 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 398 | 7 | 1 | 7 | 3.6 | COCC(C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 46891091 | 13594 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 8 | 1 | 7 | 4.2 | COCC(C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1083948 | 13594 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 8 | 1 | 7 | 4.2 | COCC(C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 46891034 | 14174 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 420 | 5 | 1 | 5 | 5.4 | CCC(C1CC1)n1nc(C)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1086509 | 14174 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 420 | 5 | 1 | 5 | 5.4 | CCC(C1CC1)n1nc(C)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 44190240 | 203519 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 382 | 4 | 1 | 5 | 4.8 | C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900301y | |||
| CHEMBL565144 | 203519 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 382 | 4 | 1 | 5 | 4.8 | C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C#N)cc2Cl)c1=O | 10.1021/jm900301y | |||
| 24768327 | 104813 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 392 | 7 | 2 | 6 | 4.4 | CC[C@@H](CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)OC | 10.1021/jm070579c | |||
| CHEMBL273040 | 104813 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 392 | 7 | 2 | 6 | 4.4 | CC[C@@H](CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)OC | 10.1021/jm070579c | |||
| 24768327 | 104813 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 392 | 7 | 2 | 6 | 4.4 | CC[C@@H](CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)OC | 10.1021/jm070579c | |||
| CHEMBL273040 | 104813 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 392 | 7 | 2 | 6 | 4.4 | CC[C@@H](CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)OC | 10.1021/jm070579c | |||
| 42618185 | 186595 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 369 | 6 | 0 | 7 | 3.6 | CCCN(C)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL474499 | 186595 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 369 | 6 | 0 | 7 | 3.6 | CCCN(C)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 52918269 | 67815 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 397 | 8 | 0 | 8 | 3.2 | COc1ccc(-c2c(C)nn3c(N(CCC#N)CCCF)nc(C)nc23)c(C)n1 | 10.1016/j.bmcl.2011.02.050 | |||
| CHEMBL1762822 | 67815 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 397 | 8 | 0 | 8 | 3.2 | COc1ccc(-c2c(C)nn3c(N(CCC#N)CCCF)nc(C)nc23)c(C)n1 | 10.1016/j.bmcl.2011.02.050 | |||
| 46891289 | 13655 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 343 | 6 | 1 | 7 | 3.1 | CCC(C1CC1)n1nc(C)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1084205 | 13655 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 343 | 6 | 1 | 7 | 3.1 | CCC(C1CC1)n1nc(C)nc(Nc2cc(C)c(OC)nc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 46891553 | 14115 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 395 | 8 | 1 | 8 | 2.9 | COC[C@H](C1CC1)n1nc(C)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1086240 | 14115 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 395 | 8 | 1 | 8 | 2.9 | COC[C@H](C1CC1)n1nc(C)nc(Nc2cc(C)c(OC(F)F)nc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 44191014 | 201805 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 441 | 5 | 1 | 5 | 5.8 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL549320 | 201805 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 441 | 5 | 1 | 5 | 5.8 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 44190335 | 202854 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 331 | 5 | 1 | 4 | 4.6 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2ccc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL560633 | 202854 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 331 | 5 | 1 | 4 | 4.6 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2ccc(C)cc2C)c1=O | 10.1021/jm900301y | |||
| 42618228 | 187438 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 370 | 7 | 0 | 8 | 2.6 | CCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL475507 | 187438 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 370 | 7 | 0 | 8 | 2.6 | CCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 46891230 | 13165 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 369 | 5 | 1 | 7 | 3.1 | COc1ccc(Nc2nc(C)nn(C(C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082300 | 13165 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 369 | 5 | 1 | 7 | 3.1 | COc1ccc(Nc2nc(C)nn(C(C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 127047692 | 146635 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 441 | 8 | 1 | 8 | 4.1 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COc3cccnc3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3799211 | 146635 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 441 | 8 | 1 | 8 | 4.1 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COc3cccnc3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 44190557 | 203311 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 379 | 5 | 1 | 7 | 3.3 | COc1ccc(Nc2nc(C#N)cn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1021/jm900301y | |||
| CHEMBL563652 | 203311 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 379 | 5 | 1 | 7 | 3.3 | COc1ccc(Nc2nc(C#N)cn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1021/jm900301y | |||
| 10377 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | |||
| 9818802 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | |||
| CHEMBL270738 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | |||
| 10377 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070578k | |||
| 9818802 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070578k | |||
| CHEMBL270738 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070578k | |||
| 10377 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm200365y | |||
| 9818802 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm200365y | |||
| CHEMBL270738 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm200365y | |||
| 127047549 | 146740 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 466 | 8 | 1 | 9 | 4.0 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COc3cc(C#N)ccn3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3799801 | 146740 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 466 | 8 | 1 | 9 | 4.0 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COc3cc(C#N)ccn3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 46881790 | 14038 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 387 | 5 | 1 | 6 | 4.2 | Cc1cc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)nc1N1CCCC1 | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1085930 | 14038 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 387 | 5 | 1 | 6 | 4.2 | Cc1cc(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)nc1N1CCCC1 | 10.1016/j.bmcl.2010.01.129 | |||
| 10377 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | |||
| 9818802 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | |||
| CHEMBL270738 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070579c | |||
| 10377 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070578k | |||
| 9818802 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070578k | |||
| CHEMBL270738 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070578k | |||
| 10377 | 7962 | 27 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070578k | |||
| 9818802 | 7962 | 27 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070578k | |||
| CHEMBL270738 | 7962 | 27 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1021/jm070578k | |||
| 24768333 | 92359 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 400 | 8 | 1 | 8 | 2.9 | CCCCN(CC)c1nc(C)nc2c1NC(=O)CN2c1ccc(OC)nc1OC | 10.1021/jm0611410 | |||
| CHEMBL228169 | 92359 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 400 | 8 | 1 | 8 | 2.9 | CCCCN(CC)c1nc(C)nc2c1NC(=O)CN2c1ccc(OC)nc1OC | 10.1021/jm0611410 | |||
| 46891157 | 13265 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 323 | 4 | 1 | 6 | 3.2 | Cc1nc(Nc2cc(C)c(C#N)cc2C)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082705 | 13265 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 323 | 4 | 1 | 6 | 3.2 | Cc1nc(Nc2cc(C)c(C#N)cc2C)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 44589305 | 195482 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 390 | 4 | 0 | 8 | 3.8 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C)n1 | 10.1021/jm800743q | |||
| CHEMBL504383 | 195482 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 390 | 4 | 0 | 8 | 3.8 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C)n1 | 10.1021/jm800743q | |||
| 10294046 | 71528 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 394 | 7 | 1 | 6 | 4.8 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)c(OC)c4)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819079 | 71528 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 394 | 7 | 1 | 6 | 4.8 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)c(OC)c4)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 58223382 | 89375 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 519 | 11 | 0 | 9 | 5.0 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4(F)CCOCC4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL2179178 | 89375 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 519 | 11 | 0 | 9 | 5.0 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4(F)CCOCC4)c(OC)nn23)c(OC)c1 | nan | |||
| 58223515 | 134653 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 12 | 0 | 9 | 5.0 | COCCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCCC1 | nan | |||
| CHEMBL3664588 | 134653 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 12 | 0 | 9 | 5.0 | COCCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCCC1 | nan | |||
| 58223449 | 134654 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 457 | 8 | 0 | 8 | 5.0 | CCN(c1c(OC)nn2c(-c3c(OC)cc(C4CC4)cc3OC)csc12)C1CCOCC1 | nan | |||
| CHEMBL3664589 | 134654 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 457 | 8 | 0 | 8 | 5.0 | CCN(c1c(OC)nn2c(-c3c(OC)cc(C4CC4)cc3OC)csc12)C1CCOCC1 | nan | |||
| 58223517 | 134660 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 500 | 12 | 0 | 9 | 5.0 | COCc1cc(OC)c(-c2csc3c(N(CCCF)Cc4ccncc4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664594 | 134660 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 500 | 12 | 0 | 9 | 5.0 | COCc1cc(OC)c(-c2csc3c(N(CCCF)Cc4ccncc4)c(OC)nn23)c(OC)c1 | nan | |||
| 56673724 | 72075 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 373 | 8 | 1 | 6 | 4.8 | CCCN(CCC)c1cc(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828888 | 72075 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 373 | 8 | 1 | 6 | 4.8 | CCCN(CCC)c1cc(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 58223382 | 89375 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 519 | 11 | 0 | 9 | 5.0 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4(F)CCOCC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| CHEMBL2179178 | 89375 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 519 | 11 | 0 | 9 | 5.0 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4(F)CCOCC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| 21912450 | 104788 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 343 | 7 | 1 | 4 | 5.2 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(CO)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL272904 | 104788 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 343 | 7 | 1 | 4 | 5.2 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(CO)cc2C)c1C | 10.1021/jm070578k | |||
| 21912450 | 104788 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 343 | 7 | 1 | 4 | 5.2 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(CO)cc2C)c1C | 10.1021/jm070578k | |||
| CHEMBL272904 | 104788 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 343 | 7 | 1 | 4 | 5.2 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(CO)cc2C)c1C | 10.1021/jm070578k | |||
| 58223461 | 134674 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 499 | 11 | 0 | 9 | 4.3 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4C5COCC54)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664608 | 134674 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 499 | 11 | 0 | 9 | 4.3 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4C5COCC54)c(OC)nn23)c(OC)c1 | nan | |||
| 71455050 | 88287 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(Cl)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160161 | 88287 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(Cl)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 22177936 | 71520 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 424 | 8 | 1 | 6 | 5.7 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(CSC)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819070 | 71520 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 424 | 8 | 1 | 6 | 5.7 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(CSC)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 10495051 | 193955 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 308 | 3 | 1 | 4 | 4.4 | CCNc1nc(C)nc2c1c(C)cn2-c1c(C)cc(C)cc1C | 10.1021/jm960861b | |||
| CHEMBL49217 | 193955 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 308 | 3 | 1 | 4 | 4.4 | CCNc1nc(C)nc2c1c(C)cn2-c1c(C)cc(C)cc1C | 10.1021/jm960861b | |||
| 10161139 | 71971 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 450 | 8 | 0 | 4 | 6.9 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)C(CC)N2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL182497 | 71971 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 450 | 8 | 0 | 4 | 6.9 | CCCC(CCC)n1c(CC)nc2c1C(=O)N(C)C(CC)N2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 58223442 | 134667 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 503 | 12 | 0 | 9 | 5.4 | CCCCN(c1c(OCC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCOCC1 | nan | |||
| CHEMBL3664601 | 134667 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 503 | 12 | 0 | 9 | 5.4 | CCCCN(c1c(OCC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCOCC1 | nan | |||
| 44478733 | 89390 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 479 | 9 | 0 | 8 | 5.3 | CCCN(c1c(OC)nn2c(-c3c(Cl)cc(COC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| CHEMBL2179193 | 89390 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 479 | 9 | 0 | 8 | 5.3 | CCCN(c1c(OC)nn2c(-c3c(Cl)cc(COC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| 44191106 | 203137 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 435 | 5 | 1 | 6 | 4.3 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(S(C)(=O)=O)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL562492 | 203137 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 435 | 5 | 1 | 6 | 4.3 | C[C@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(S(C)(=O)=O)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 44444335 | 101241 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 349 | 5 | 0 | 4 | 5.4 | CCC(CC)n1cc2c3c(nc(C)cc31)N(c1ccc(OC)cc1)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL251344 | 101241 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 349 | 5 | 0 | 4 | 5.4 | CCC(CC)n1cc2c3c(nc(C)cc31)N(c1ccc(OC)cc1)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| 53358379 | 137379 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 394 | 4 | 1 | 4 | 4.2 | Cc1cc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)cnc3C)CC2)n1 | nan | |||
| CHEMBL3681384 | 137379 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 394 | 4 | 1 | 4 | 4.2 | Cc1cc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(C(F)(F)F)cnc3C)CC2)n1 | nan | |||
| 58223511 | 134620 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 459 | 9 | 0 | 8 | 5.0 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(CC)cc3OC)csc12)C1CCOCC1 | nan | |||
| CHEMBL3664555 | 134620 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 459 | 9 | 0 | 8 | 5.0 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(CC)cc3OC)csc12)C1CCOCC1 | nan | |||
| 70681899 | 82360 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 480 | 10 | 0 | 7 | 5.8 | CCN(CC1CCOCC1)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2046528 | 82360 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 480 | 10 | 0 | 7 | 5.8 | CCN(CC1CCOCC1)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | |||
| 11271502 | 146184 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 476 | 10 | 1 | 7 | 4.5 | COCCN(CCOC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3793560 | 146184 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 476 | 10 | 1 | 7 | 4.5 | COCCN(CCOC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 71457262 | 89388 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 11 | 0 | 9 | 5.0 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(COCC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| CHEMBL2179191 | 89388 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 11 | 0 | 9 | 5.0 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(COCC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| 46881745 | 13993 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 332 | 4 | 1 | 5 | 3.9 | Cc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)n1 | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1085683 | 13993 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 332 | 4 | 1 | 5 | 3.9 | Cc1cc(C)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)c(C)n1 | 10.1016/j.bmcl.2010.01.129 | |||
| 58223516 | 134663 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 493 | 11 | 0 | 8 | 5.7 | COCCCN(c1c(OC)nn2c(-c3c(Cl)cc(COC)cc3OC)csc12)C1CCCC1 | nan | |||
| CHEMBL3664597 | 134663 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 493 | 11 | 0 | 8 | 5.7 | COCCCN(c1c(OC)nn2c(-c3c(Cl)cc(COC)cc3OC)csc12)C1CCCC1 | nan | |||
| 57786313 | 171763 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 418 | 3 | 0 | 4 | 6.6 | CCC(C#N)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4225575 | 171763 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 418 | 3 | 0 | 4 | 6.6 | CCC(C#N)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| 11223423 | 196321 | 30 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 404 | 4 | 1 | 6 | 3.1 | COc1ccc(N2CCc3c(-n4ccc(N5CCNC5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| CHEMBL514270 | 196321 | 30 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 404 | 4 | 1 | 6 | 3.1 | COc1ccc(N2CCc3c(-n4ccc(N5CCNC5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| 53358376 | 137383 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 376 | 5 | 2 | 5 | 3.0 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2nc(CO)cc2C)CC1 | nan | |||
| CHEMBL3681388 | 137383 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 376 | 5 | 2 | 5 | 3.0 | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2nc(CO)cc2C)CC1 | nan | |||
| 56683764 | 72277 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 387 | 8 | 0 | 6 | 4.8 | CCCN(CCC)c1cc(N(C)c2ccc(OC)cc2Cl)nc2nccn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830520 | 72277 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 387 | 8 | 0 | 6 | 4.8 | CCCN(CCC)c1cc(N(C)c2ccc(OC)cc2Cl)nc2nccn12 | 10.1016/j.bmc.2011.08.055 | |||
| 71449705 | 88283 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(OC)c2nc(-c3c(Cl)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160157 | 88283 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(OC)c2nc(-c3c(Cl)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 127047520 | 146846 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 469 | 8 | 1 | 9 | 3.9 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)c3ccccn3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3800457 | 146846 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 469 | 8 | 1 | 9 | 3.9 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COC(=O)c3ccccn3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 3520 | 10041 | 54 | None | 1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmc.2016.11.011 | |||
| 9821250 | 10041 | 54 | None | 1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL309138 | 10041 | 54 | None | 1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmc.2016.11.011 | |||
| 53357658 | 137386 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 429 | 5 | 1 | 4 | 4.9 | COc1cc(C)nn1C[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | |||
| CHEMBL3681391 | 137386 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 429 | 5 | 1 | 4 | 4.9 | COc1cc(C)nn1C[C@H]1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2Cl)CC1 | nan | |||
| 11317069 | 181760 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 458 | 4 | 1 | 6 | 4.0 | Cc1cc(-n2ccc(N3CCNC3=O)n2)c2c(n1)N(c1ccc(OC(F)(F)F)cc1C)CC2 | 10.1021/jm800744m | |||
| CHEMBL456640 | 181760 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 458 | 4 | 1 | 6 | 4.0 | Cc1cc(-n2ccc(N3CCNC3=O)n2)c2c(n1)N(c1ccc(OC(F)(F)F)cc1C)CC2 | 10.1021/jm800744m | |||
| 11350078 | 196566 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 399 | 3 | 1 | 6 | 3.0 | Cc1cc(-n2ccc(N3CCNC3=O)n2)c2c(n1)N(c1ccc(C#N)cc1C)CC2 | 10.1021/jm800744m | |||
| CHEMBL516170 | 196566 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 399 | 3 | 1 | 6 | 3.0 | Cc1cc(-n2ccc(N3CCNC3=O)n2)c2c(n1)N(c1ccc(C#N)cc1C)CC2 | 10.1021/jm800744m | |||
| 70692632 | 82676 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 392 | 7 | 1 | 5 | 5.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)n(C)c12 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2049191 | 82676 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 392 | 7 | 1 | 5 | 5.2 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)n(C)c12 | 10.1016/j.bmcl.2012.05.066 | |||
| 46890980 | 13612 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 328 | 5 | 1 | 6 | 3.3 | COc1cc(C)c(Nc2nc(C)nn(C(C)C3CC3)c2=O)c(C)c1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1084026 | 13612 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 328 | 5 | 1 | 6 | 3.3 | COc1cc(C)c(Nc2nc(C)nn(C(C)C3CC3)c2=O)c(C)c1 | 10.1016/j.bmcl.2010.04.121 | |||
| 44397042 | 19042 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 408 | 6 | 2 | 5 | 4.6 | CCC(CNc1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1Cl)OC | 10.1021/jm049737f | |||
| CHEMBL1184732 | 19042 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 408 | 6 | 2 | 5 | 4.6 | CCC(CNc1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1Cl)OC | 10.1021/jm049737f | |||
| CHEMBL365868 | 19042 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 408 | 6 | 2 | 5 | 4.6 | CCC(CNc1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1Cl)OC | 10.1021/jm049737f | |||
| 56683761 | 72269 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 431 | 11 | 0 | 7 | 4.8 | CCCN(CCC)c1cc(N(CCOC)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830513 | 72269 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 431 | 11 | 0 | 7 | 4.8 | CCCN(CCC)c1cc(N(CCOC)c2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 71451919 | 89373 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 501 | 11 | 0 | 9 | 4.9 | COCc1cc(OC)c(-c2csc3c(N(CC4CCOCC4)CC4CC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| CHEMBL2179176 | 89373 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 501 | 11 | 0 | 9 | 4.9 | COCc1cc(OC)c(-c2csc3c(N(CC4CCOCC4)CC4CC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| 46891389 | 13258 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 398 | 7 | 1 | 7 | 3.6 | COC[C@@H](C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082671 | 13258 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 398 | 7 | 1 | 7 | 3.6 | COC[C@@H](C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 58896587 | 180148 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 449 | 6 | 1 | 6 | 6.5 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(c3ccc(C)cn3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4527586 | 180148 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 449 | 6 | 1 | 6 | 6.5 | COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(c3ccc(C)cn3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| 155548925 | 180594 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 503 | 6 | 1 | 6 | 6.8 | COc1cc(Br)cc(C)c1Nc1nc2cccc(N(c3cccc(C#N)c3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4538409 | 180594 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 503 | 6 | 1 | 6 | 6.8 | COc1cc(Br)cc(C)c1Nc1nc2cccc(N(c3cccc(C#N)c3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| 53358268 | 137382 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 376 | 5 | 2 | 5 | 3.0 | Cc1cc(CO)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)n1 | nan | |||
| CHEMBL3681387 | 137382 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 376 | 5 | 2 | 5 | 3.0 | Cc1cc(CO)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)n1 | nan | |||
| 11703582 | 72285 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 378 | 7 | 0 | 6 | 5.4 | CCc1ccc(Oc2nc3ccnn3c3c2ccn3C(CC)CC)c(OC)c1 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830528 | 72285 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 378 | 7 | 0 | 6 | 5.4 | CCc1ccc(Oc2nc3ccnn3c3c2ccn3C(CC)CC)c(OC)c1 | 10.1016/j.bmc.2011.08.055 | |||
| 10376 | 9704 | 4 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 5.5 | CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC | 10.1016/j.bmc.2011.07.055 | |||
| 9801039 | 9704 | 4 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 5.5 | CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819077 | 9704 | 4 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 398 | 6 | 1 | 5 | 5.5 | CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC | 10.1016/j.bmc.2011.07.055 | |||
| 56668633 | 71535 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 6 | 4.9 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4Cl)c(C)nn13)CCO2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819086 | 71535 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 6 | 4.9 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4Cl)c(C)nn13)CCO2 | 10.1016/j.bmc.2011.07.055 | |||
| 42618221 | 186411 | 11 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](C)Nc1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL474288 | 186411 | 11 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](C)Nc1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 56670271 | 72283 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 360 | 5 | 0 | 4 | 5.6 | CCC(CC)n1ccc2c(Cc3c(C)cc(C)cc3C)nc3ccnn3c21 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830526 | 72283 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 360 | 5 | 0 | 4 | 5.6 | CCC(CC)n1ccc2c(Cc3c(C)cc(C)cc3C)nc3ccnn3c21 | 10.1016/j.bmc.2011.08.055 | |||
| 57786006 | 171742 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 4 | 0 | 4 | 6.4 | CCN(CC)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4225254 | 171742 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 4 | 0 | 4 | 6.4 | CCN(CC)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| 11407418 | 73495 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 6 | 1 | 4 | 4.9 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccccc1Br | 10.1021/jm049737f | |||
| CHEMBL185648 | 73495 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 6 | 1 | 4 | 4.9 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccccc1Br | 10.1021/jm049737f | |||
| 46891492 | 13336 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 398 | 7 | 1 | 7 | 3.6 | COC[C@H](C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1083011 | 13336 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 398 | 7 | 1 | 7 | 3.6 | COC[C@H](C1CC1)n1nc(C)nc(Nc2c(Cl)cc(OC)cc2Cl)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 46891441 | 13840 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 404 | 6 | 1 | 6 | 4.6 | Cc1nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c(=O)n([C@@H](C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1084988 | 13840 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 404 | 6 | 1 | 6 | 4.6 | Cc1nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c(=O)n([C@@H](C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 10405373 | 104178 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 346 | 6 | 1 | 3 | 6.4 | CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C | 10.1021/jm070579c | |||
| CHEMBL269833 | 104178 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 346 | 6 | 1 | 3 | 6.4 | CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C | 10.1021/jm070579c | |||
| 10405373 | 104178 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 346 | 6 | 1 | 3 | 6.4 | CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C | 10.1021/jm070579c | |||
| CHEMBL269833 | 104178 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 346 | 6 | 1 | 3 | 6.4 | CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C | 10.1021/jm070579c | |||
| 54754515 | 72074 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 373 | 7 | 2 | 6 | 5.0 | CCC(CC)Nc1c(C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828887 | 72074 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 373 | 7 | 2 | 6 | 5.0 | CCC(CC)Nc1c(C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 71580314 | 95214 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 404 | 8 | 1 | 6 | 4.1 | Cc1cc(C#N)cc(C)c1Nc1nc(Cl)cn([C@@H](COCCF)C2CC2)c1=O | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL2349565 | 95214 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 404 | 8 | 1 | 6 | 4.1 | Cc1cc(C#N)cc(C)c1Nc1nc(Cl)cn([C@@H](COCCF)C2CC2)c1=O | 10.1016/j.bmcl.2013.02.009 | |||
| 24758075 | 76757 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 350 | 5 | 0 | 4 | 5.3 | CCC(CC)c1cc(C)n2nc(-c3cnc(N(C)C)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939577 | 76757 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 350 | 5 | 0 | 4 | 5.3 | CCC(CC)c1cc(C)n2nc(-c3cnc(N(C)C)cc3C)c(C)cc12 | 10.1016/j.bmc.2011.11.015 | |||
| 58012370 | 164939 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 433 | 8 | 1 | 4 | 7.6 | CCCC(CCC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4087369 | 164939 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 433 | 8 | 1 | 4 | 7.6 | CCCC(CCC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 46891440 | 13169 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 368 | 5 | 1 | 6 | 4.0 | COc1cc(Cl)c(Nc2nc(C)nn([C@@H](C)C3CC3)c2=O)c(Cl)c1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082309 | 13169 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 368 | 5 | 1 | 6 | 4.0 | COc1cc(Cl)c(Nc2nc(C)nn([C@@H](C)C3CC3)c2=O)c(Cl)c1 | 10.1016/j.bmcl.2010.04.121 | |||
| 44191185 | 202714 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 416 | 4 | 1 | 5 | 5.2 | C[C@H](C1CC1)n1cc(C#N)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL559443 | 202714 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 416 | 4 | 1 | 5 | 5.2 | C[C@H](C1CC1)n1cc(C#N)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 127030925 | 146271 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 5.4 | CCN(CC)c1ccc(C)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3794475 | 146271 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 5.4 | CCN(CC)c1ccc(C)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 10713700 | 108687 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 362 | 5 | 0 | 4 | 5.4 | C/C=C/CN(CC)c1nc(C)nc2c1c(C)cn2-c1c(C)cc(C)cc1C | 10.1021/jm960861b | |||
| CHEMBL300935 | 108687 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 362 | 5 | 0 | 4 | 5.4 | C/C=C/CN(CC)c1nc(C)nc2c1c(C)cn2-c1c(C)cc(C)cc1C | 10.1021/jm960861b | |||
| 71580216 | 95210 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 440 | 9 | 1 | 7 | 4.1 | COc1cc(Cl)c(Nc2nc(C#N)cn([C@@H](COCCF)C3CC3)c2=O)c(Cl)c1 | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL2349561 | 95210 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 440 | 9 | 1 | 7 | 4.1 | COc1cc(Cl)c(Nc2nc(C#N)cn([C@@H](COCCF)C3CC3)c2=O)c(Cl)c1 | 10.1016/j.bmcl.2013.02.009 | |||
| 127047691 | 146458 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 466 | 8 | 1 | 9 | 4.0 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COc3ccc(C#N)cn3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3797955 | 146458 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 466 | 8 | 1 | 9 | 4.0 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](COc3ccc(C#N)cn3)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 56961967 | 88770 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 425 | 8 | 1 | 7 | 3.2 | COCC(COC)n1cc(Br)nc(Nc2c(C)cc(OC)cc2C)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL2165200 | 88770 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 425 | 8 | 1 | 7 | 3.2 | COCC(COC)n1cc(Br)nc(Nc2c(C)cc(OC)cc2C)c1=O | 10.1016/j.bmcl.2012.08.112 | |||
| 57400679 | 76764 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 383 | 7 | 1 | 6 | 3.7 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CCO)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939584 | 76764 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 383 | 7 | 1 | 6 | 3.7 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CCO)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 57393714 | 76778 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 367 | 5 | 0 | 6 | 3.7 | CCC(CC)c1cc(C)n2nc(-c3ccc(N(C)C)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939598 | 76778 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 367 | 5 | 0 | 6 | 3.7 | CCC(CC)c1cc(C)n2nc(-c3ccc(N(C)C)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 44191105 | 202027 | 1 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 425 | 4 | 1 | 4 | 5.9 | C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL551029 | 202027 | 1 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 425 | 4 | 1 | 4 | 5.9 | C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 58012303 | 163570 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 409 | 5 | 1 | 3 | 7.5 | CCC(CC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3Cl)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4070898 | 163570 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 409 | 5 | 1 | 3 | 7.5 | CCC(CC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3Cl)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 42618190 | 186058 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 429 | 10 | 0 | 9 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL473076 | 186058 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 429 | 10 | 0 | 9 | 2.8 | COCCN(CCOC)c1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | 10.1021/jm9000242 | |||
| 60141295 | 82363 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 410 | 9 | 0 | 6 | 5.3 | CCN(CC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2046534 | 82363 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 410 | 9 | 0 | 6 | 5.3 | CCN(CC)c1cccc2nc(Oc3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | |||
| 57912459 | 89392 | 5 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 503 | 12 | 0 | 9 | 5.4 | CCCCN(c1c(OC)nn2c(-c3c(OC)cc(COCC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| CHEMBL2179195 | 89392 | 5 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 503 | 12 | 0 | 9 | 5.4 | CCCCN(c1c(OC)nn2c(-c3c(OC)cc(COCC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| 58223389 | 134614 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 505 | 12 | 0 | 10 | 4.5 | CCCCN(CC1COCOC1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| CHEMBL3664549 | 134614 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 505 | 12 | 0 | 10 | 4.5 | CCCCN(CC1COCOC1)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| 22178019 | 71529 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 412 | 7 | 1 | 5 | 5.8 | CCOc1ccc(-c2c(C)nn3c(NC(CC)CC)c4c(nc23)CCC4)c(Cl)c1 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819080 | 71529 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 412 | 7 | 1 | 5 | 5.8 | CCOc1ccc(-c2c(C)nn3c(NC(CC)CC)c4c(nc23)CCC4)c(Cl)c1 | 10.1016/j.bmc.2011.07.055 | |||
| 24768345 | 92305 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 395 | 7 | 1 | 6 | 4.0 | CCCCN(CC)c1nc(C)nc2c1NC(=O)CN2c1ccc(C(C)=O)cc1C | 10.1021/jm0611410 | |||
| CHEMBL227572 | 92305 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 395 | 7 | 1 | 6 | 4.0 | CCCCN(CC)c1nc(C)nc2c1NC(=O)CN2c1ccc(C(C)=O)cc1C | 10.1021/jm0611410 | |||
| 22177924 | 71521 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4ccc(C)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819071 | 71521 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4ccc(C)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 46881791 | 14039 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 372 | 4 | 1 | 5 | 4.3 | Cc1nc(C(F)(F)F)ccc1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1085931 | 14039 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 372 | 4 | 1 | 5 | 4.3 | Cc1nc(C(F)(F)F)ccc1Nc1nc(Cl)cn([C@H](C)C2CC2)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| 58223439 | 134652 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 475 | 12 | 0 | 9 | 4.6 | COCCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCC1 | nan | |||
| CHEMBL3664587 | 134652 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 475 | 12 | 0 | 9 | 4.6 | COCCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCC1 | nan | |||
| 58223408 | 134627 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 465 | 8 | 0 | 8 | 5.1 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(Cl)cc3OC)csc12)C1CCOCC1 | nan | |||
| CHEMBL3664562 | 134627 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 465 | 8 | 0 | 8 | 5.1 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(Cl)cc3OC)csc12)C1CCOCC1 | nan | |||
| 58223434 | 135592 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 517 | 12 | 0 | 9 | 5.8 | CCCCN(c1c(OC)nn2c(-c3c(OC)cc(COC(C)C)cc3OC)csc12)C1CCOCC1 | nan | |||
| CHEMBL3669432 | 135592 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 517 | 12 | 0 | 9 | 5.8 | CCCCN(c1c(OC)nn2c(-c3c(OC)cc(COC(C)C)cc3OC)csc12)C1CCOCC1 | nan | |||
| 46881746 | 13696 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 346 | 4 | 1 | 6 | 3.3 | Cc1nc2c(cc1Nc1nc(Cl)cn([C@H](C)C3CC3)c1=O)COC2 | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1084422 | 13696 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 346 | 4 | 1 | 6 | 3.3 | Cc1nc2c(cc1Nc1nc(Cl)cn([C@H](C)C3CC3)c1=O)COC2 | 10.1016/j.bmcl.2010.01.129 | |||
| 21912204 | 104481 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 325 | 6 | 2 | 3 | 6.0 | CCC(CC)Nc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C | 10.1021/jm070579c | |||
| CHEMBL271368 | 104481 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 325 | 6 | 2 | 3 | 6.0 | CCC(CC)Nc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C | 10.1021/jm070579c | |||
| 44589258 | 182457 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 395 | 3 | 0 | 8 | 3.8 | N#Cc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C#N)c1 | 10.1021/jm800743q | |||
| CHEMBL458177 | 182457 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 395 | 3 | 0 | 8 | 3.8 | N#Cc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C#N)c1 | 10.1021/jm800743q | |||
| 70690480 | 82679 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 6.9 | Cc1cc(C)c(Nc2nc3cccc(N(CC4CCOCC4)CC4CC4)c3cc2C)c(C)c1 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2049195 | 82679 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 6.9 | Cc1cc(C)c(Nc2nc3cccc(N(CC4CCOCC4)CC4CC4)c3cc2C)c(C)c1 | 10.1016/j.bmcl.2012.05.066 | |||
| 58223505 | 134662 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 12 | 0 | 9 | 5.0 | COCc1cc(OC)c(-c2csc3c(N(CCCF)Cc4ccccn4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664596 | 134662 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 12 | 0 | 9 | 5.0 | COCc1cc(OC)c(-c2csc3c(N(CCCF)Cc4ccccn4)c(OC)nn23)c(OC)c1 | nan | |||
| 70688433 | 82678 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 399 | 7 | 1 | 3 | 6.8 | Cc1cc(C)c(Nc2nc3cccc(N(CC4CC4)CC4CC4)c3cc2C)c(C)c1 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2049194 | 82678 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 399 | 7 | 1 | 3 | 6.8 | Cc1cc(C)c(Nc2nc3cccc(N(CC4CC4)CC4CC4)c3cc2C)c(C)c1 | 10.1016/j.bmcl.2012.05.066 | |||
| 71450106 | 89377 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 11 | 0 | 9 | 5.0 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4CCCCO4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| CHEMBL2179180 | 89377 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 11 | 0 | 9 | 5.0 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4CCCCO4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| 155541854 | 179824 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 7 | 1 | 6 | 6.6 | COc1cc(Br)cc(C)c1Nc1nc2cccc(N(c3cccc(C(=O)N(C)C)c3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4519158 | 179824 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 7 | 1 | 6 | 6.6 | COc1cc(Br)cc(C)c1Nc1nc2cccc(N(c3cccc(C(=O)N(C)C)c3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| 10127304 | 72023 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 436 | 7 | 0 | 6 | 4.9 | CCCC(CCC)n1c(CC)nc2c1c(=O)n(C)c(=O)n2-c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL182744 | 72023 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 436 | 7 | 0 | 6 | 4.9 | CCCC(CCC)n1c(CC)nc2c1c(=O)n(C)c(=O)n2-c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 9843355 | 18002 | 2 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 389 | 7 | 1 | 7 | 4.0 | COCC(COC)n1nnc2c(Nc3c(C)cc(C)cc3Cl)nc(C)cc21 | 10.1021/jm990590f | |||
| CHEMBL1178813 | 18002 | 2 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 389 | 7 | 1 | 7 | 4.0 | COCC(COC)n1nnc2c(Nc3c(C)cc(C)cc3Cl)nc(C)cc21 | 10.1021/jm990590f | |||
| CHEMBL44169 | 18002 | 2 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 389 | 7 | 1 | 7 | 4.0 | COCC(COC)n1nnc2c(Nc3c(C)cc(C)cc3Cl)nc(C)cc21 | 10.1021/jm990590f | |||
| 21912204 | 104481 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 325 | 6 | 2 | 3 | 6.0 | CCC(CC)Nc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C | 10.1021/jm070579c | |||
| CHEMBL271368 | 104481 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 325 | 6 | 2 | 3 | 6.0 | CCC(CC)Nc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C | 10.1021/jm070579c | |||
| 58223421 | 89261 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 499 | 10 | 0 | 8 | 5.5 | COCc1cc(OC)c(-c2c(C)sc3c(N(CC4CCOCC4)CC4CC4)c(C)nn23)c(OC)c1 | nan | |||
| CHEMBL2177105 | 89261 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 499 | 10 | 0 | 8 | 5.5 | COCc1cc(OC)c(-c2c(C)sc3c(N(CC4CCOCC4)CC4CC4)c(C)nn23)c(OC)c1 | nan | |||
| 58223447 | 134665 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 489 | 11 | 0 | 9 | 5.3 | CCCN(c1c(OCC)nn2c(-c3c(OC)cc(OCC)cc3OC)csc12)C1CCOCC1 | nan | |||
| CHEMBL3664599 | 134665 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 489 | 11 | 0 | 9 | 5.3 | CCCN(c1c(OCC)nn2c(-c3c(OC)cc(OCC)cc3OC)csc12)C1CCOCC1 | nan | |||
| 58223421 | 89261 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 499 | 10 | 0 | 8 | 5.5 | COCc1cc(OC)c(-c2c(C)sc3c(N(CC4CCOCC4)CC4CC4)c(C)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| CHEMBL2177105 | 89261 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 499 | 10 | 0 | 8 | 5.5 | COCc1cc(OC)c(-c2c(C)sc3c(N(CC4CCOCC4)CC4CC4)c(C)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| 44190056 | 203124 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 363 | 7 | 1 | 5 | 4.7 | CCC(CC)Cn1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL562435 | 203124 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 363 | 7 | 1 | 5 | 4.7 | CCC(CC)Cn1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O | 10.1021/jm900301y | |||
| 9865624 | 22316 | 12 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 9 | 0 | 7 | 3.9 | CCCN(CCOC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL121896 | 22316 | 12 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 9 | 0 | 7 | 3.9 | CCCN(CCOC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1021/jm040058e | |||
| 56663337 | 72087 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 427 | 10 | 0 | 6 | 5.7 | C=C(C)CN(c1cc(N(CCC)CCC)n2nccc2n1)c1ccc(OC)cc1Cl | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828899 | 72087 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 427 | 10 | 0 | 6 | 5.7 | C=C(C)CN(c1cc(N(CCC)CCC)n2nccc2n1)c1ccc(OC)cc1Cl | 10.1016/j.bmc.2011.08.055 | |||
| 70690301 | 82359 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 506 | 11 | 0 | 7 | 6.1 | COCc1cc(OC)c(Oc2nc3cccc(N(CC4CCOCC4)CC4CC4)c3cc2C)c(OC)c1 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2046527 | 82359 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 506 | 11 | 0 | 7 | 6.1 | COCc1cc(OC)c(Oc2nc3cccc(N(CC4CCOCC4)CC4CC4)c3cc2C)c(OC)c1 | 10.1016/j.bmcl.2012.05.066 | |||
| 58223384 | 134658 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 503 | 11 | 0 | 9 | 5.4 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(COC(C)C)cc3OC)csc12)C1CCOCC1 | nan | |||
| CHEMBL3664592 | 134658 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 503 | 11 | 0 | 9 | 5.4 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(COC(C)C)cc3OC)csc12)C1CCOCC1 | nan | |||
| 58896519 | 146162 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 367 | 7 | 1 | 4 | 6.6 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)sc12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3793190 | 146162 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 367 | 7 | 1 | 4 | 6.6 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)sc12 | 10.1021/acs.jmedchem.5b01715 | |||
| 54582017 | 67422 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 352 | 4 | 0 | 5 | 3.7 | CCN(CC)c1nc2c(c(-c3c(C)cc(C)cc3C)cn2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| CHEMBL1760252 | 67422 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 352 | 4 | 0 | 5 | 3.7 | CCN(CC)c1nc2c(c(-c3c(C)cc(C)cc3C)cn2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| 70686532 | 83386 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 408 | 8 | 0 | 5 | 5.5 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| CHEMBL2063372 | 83386 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 408 | 8 | 0 | 5 | 5.5 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| 70692469 | 82357 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 376 | 7 | 0 | 3 | 6.9 | CCCN(CCC)c1cccc2nc(Oc3c(C)cc(C)cc3C)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2046525 | 82357 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 376 | 7 | 0 | 3 | 6.9 | CCCN(CCC)c1cccc2nc(Oc3c(C)cc(C)cc3C)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | |||
| 9843355 | 18002 | 2 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 389 | 7 | 1 | 7 | 4.0 | COCC(COC)n1nnc2c(Nc3c(C)cc(C)cc3Cl)nc(C)cc21 | 10.1021/jm990590f | |||
| CHEMBL1178813 | 18002 | 2 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 389 | 7 | 1 | 7 | 4.0 | COCC(COC)n1nnc2c(Nc3c(C)cc(C)cc3Cl)nc(C)cc21 | 10.1021/jm990590f | |||
| CHEMBL44169 | 18002 | 2 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 389 | 7 | 1 | 7 | 4.0 | COCC(COC)n1nnc2c(Nc3c(C)cc(C)cc3Cl)nc(C)cc21 | 10.1021/jm990590f | |||
| 44444325 | 101101 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 417 | 5 | 0 | 4 | 6.6 | CCC(CC)n1cc2c3c(nc(C)cc31)N(c1ccc(OC(F)(F)F)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| CHEMBL250603 | 101101 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 417 | 5 | 0 | 4 | 6.6 | CCC(CC)n1cc2c3c(nc(C)cc31)N(c1ccc(OC(F)(F)F)cc1C)CC2 | 10.1016/j.bmcl.2007.06.077 | |||
| 11200917 | 196487 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 418 | 4 | 0 | 6 | 3.5 | COc1ccc(N2CCc3c(-n4ccc(N5CCN(C)C5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| CHEMBL515532 | 196487 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 418 | 4 | 0 | 6 | 3.5 | COc1ccc(N2CCc3c(-n4ccc(N5CCN(C)C5=O)n4)cc(C)nc32)c(C)c1 | 10.1021/jm800744m | |||
| 11383650 | 72076 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 387 | 8 | 1 | 6 | 5.1 | CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1828889 | 72076 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 387 | 8 | 1 | 6 | 5.1 | CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 56659948 | 72273 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 388 | 8 | 1 | 7 | 4.5 | CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | |||
| CHEMBL1830517 | 72273 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 388 | 8 | 1 | 7 | 4.5 | CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2ncnn12 | 10.1016/j.bmc.2011.08.055 | |||
| 42618200 | 190944 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 449 | 10 | 0 | 9 | 3.2 | COCCN(CCOC)c1nc(C)nc2c(-c3cc(OC)c(OC)cc3Cl)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL482983 | 190944 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 449 | 10 | 0 | 9 | 3.2 | COCCN(CCOC)c1nc(C)nc2c(-c3cc(OC)c(OC)cc3Cl)c(C)nn12 | 10.1021/jm9000242 | |||
| 42618233 | 190994 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 354 | 6 | 0 | 7 | 3.4 | CCCCN(C)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL483350 | 190994 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 354 | 6 | 0 | 7 | 3.4 | CCCCN(C)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 24768344 | 92317 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 380 | 7 | 1 | 5 | 5.1 | CCCCN(CC)c1cc(C)nc2c1NCCN2c1ccc(C(C)=O)cc1C | 10.1021/jm0611410 | |||
| CHEMBL227731 | 92317 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 380 | 7 | 1 | 5 | 5.1 | CCCCN(CC)c1cc(C)nc2c1NCCN2c1ccc(C(C)=O)cc1C | 10.1021/jm0611410 | |||
| 44191110 | 202404 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 371 | 5 | 1 | 5 | 4.4 | COc1cc(Cl)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1F | 10.1021/jm900302q | |||
| CHEMBL556255 | 202404 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 371 | 5 | 1 | 5 | 4.4 | COc1cc(Cl)c(Nc2nc(Cl)cn([C@H](C)C3CC3)c2=O)cc1F | 10.1021/jm900302q | |||
| 46891340 | 13252 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 368 | 5 | 1 | 6 | 4.0 | COc1cc(Cl)c(Nc2nc(C)nn([C@H](C)C3CC3)c2=O)c(Cl)c1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082665 | 13252 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 368 | 5 | 1 | 6 | 4.0 | COc1cc(Cl)c(Nc2nc(C)nn([C@H](C)C3CC3)c2=O)c(Cl)c1 | 10.1016/j.bmcl.2010.04.121 | |||
| 25114821 | 76772 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 390 | 6 | 0 | 6 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3cnc(OC(F)F)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939592 | 76772 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 390 | 6 | 0 | 6 | 4.2 | CCC(CC)c1cc(C)n2nc(-c3cnc(OC(F)F)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 3520 | 10041 | 54 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/acs.jmedchem.5b01715 | |||
| 9821250 | 10041 | 54 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL309138 | 10041 | 54 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/acs.jmedchem.5b01715 | |||
| 42618227 | 196346 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 400 | 9 | 0 | 9 | 2.2 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL514465 | 196346 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 400 | 9 | 0 | 9 | 2.2 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 44191011 | 203026 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.8 | COCC(COC)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| CHEMBL561757 | 203026 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.8 | COCC(COC)n1cc(Cl)nc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)c1=O | 10.1021/jm900302q | |||
| 57400680 | 76771 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 354 | 5 | 0 | 6 | 3.6 | CCC(CC)c1cc(C)n2nc(-c3cnc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939591 | 76771 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 354 | 5 | 0 | 6 | 3.6 | CCC(CC)c1cc(C)n2nc(-c3cnc(OC)cc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 46891388 | 13257 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 383 | 6 | 1 | 7 | 3.5 | CCOc1ccc(Nc2nc(C)nn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082670 | 13257 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 383 | 6 | 1 | 7 | 3.5 | CCOc1ccc(Nc2nc(C)nn([C@H](C)C3CC3)c2=O)c(C(F)(F)F)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 24964079 | 165743 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 401 | 5 | 0 | 4 | 6.8 | CCC(CC)c1ccc(Cl)c2nc(Oc3c(C)cc(C#N)cc3Cl)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL4096045 | 165743 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 401 | 5 | 0 | 4 | 6.8 | CCC(CC)c1ccc(Cl)c2nc(Oc3c(C)cc(C#N)cc3Cl)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 57402455 | 76776 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 345 | 3 | 0 | 5 | 3.8 | COc1ccc(-c2nn3c(C)cc(C(C)C)c3c(=O)n2C)c(Cl)c1 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939596 | 76776 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 345 | 3 | 0 | 5 | 3.8 | COc1ccc(-c2nn3c(C)cc(C(C)C)c3c(=O)n2C)c(Cl)c1 | 10.1016/j.bmc.2011.11.015 | |||
| 24758076 | 76756 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 380 | 7 | 0 | 4 | 6.1 | CCc1cc(OC)c(OC)cc1-c1nn2c(C)cc(C(CC)CC)c2cc1C | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939576 | 76756 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 380 | 7 | 0 | 4 | 6.1 | CCc1cc(OC)c(OC)cc1-c1nn2c(C)cc(C(CC)CC)c2cc1C | 10.1016/j.bmc.2011.11.015 | |||
| 58223396 | 134673 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 487 | 11 | 0 | 9 | 4.3 | CCCN(CC1C2COCC21)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| CHEMBL3664607 | 134673 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 487 | 11 | 0 | 9 | 4.3 | CCCN(CC1C2COCC21)c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12 | nan | |||
| 58223425 | 134675 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 469 | 9 | 0 | 8 | 4.7 | CCN(CC1C2COCC21)c1c(OC)nn2c(-c3c(OC)cc(C4CC4)cc3OC)csc12 | nan | |||
| CHEMBL3664609 | 134675 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 469 | 9 | 0 | 8 | 4.7 | CCN(CC1C2COCC21)c1c(OC)nn2c(-c3c(OC)cc(C4CC4)cc3OC)csc12 | nan | |||
| 10222402 | 71512 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 396 | 6 | 1 | 6 | 5.3 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CCS2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819062 | 71512 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 396 | 6 | 1 | 6 | 5.3 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4C)c(C)nn13)CCS2 | 10.1016/j.bmc.2011.07.055 | |||
| 42618173 | 196368 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 337 | 3 | 0 | 6 | 3.3 | COc1ccc(-c2c(C)nn3c(N4CCCC4)nc(C)nc23)c(C)c1 | 10.1021/jm9000242 | |||
| CHEMBL514649 | 196368 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 337 | 3 | 0 | 6 | 3.3 | COc1ccc(-c2c(C)nn3c(N4CCCC4)nc(C)nc23)c(C)c1 | 10.1021/jm9000242 | |||
| 70684376 | 83394 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(Cl)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| CHEMBL2063382 | 83394 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(Cl)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| 70684376 | 83394 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(Cl)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2063382 | 83394 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCN(CC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(Cl)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 57400683 | 76781 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 353 | 4 | 0 | 6 | 3.3 | CCC(C)c1cc(C)n2nc(-c3ccc(N(C)C)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939600 | 76781 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 353 | 4 | 0 | 6 | 3.3 | CCC(C)c1cc(C)n2nc(-c3ccc(N(C)C)nc3C)n(C)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 42618231 | 180254 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 326 | 4 | 0 | 7 | 2.6 | CCN(C)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL453001 | 180254 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 326 | 4 | 0 | 7 | 2.6 | CCN(C)c1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 53357409 | 137380 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 505 | 6 | 1 | 4 | 6.5 | COc1ccc(-c2cc(C)n(C[C@H]3CC[C@H](NC(=O)c4cc(C(F)(F)F)ccc4Cl)CC3)n2)cc1 | nan | |||
| CHEMBL3681385 | 137380 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 505 | 6 | 1 | 4 | 6.5 | COc1ccc(-c2cc(C)n(C[C@H]3CC[C@H](NC(=O)c4cc(C(F)(F)F)ccc4Cl)CC3)n2)cc1 | nan | |||
| 3499 | 8230 | 28 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm990590f | |||
| 9909468 | 8230 | 28 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm990590f | |||
| CHEMBL44698 | 8230 | 28 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm990590f | |||
| 22177795 | 71524 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4cc(C)ccc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819074 | 71524 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4cc(C)ccc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 51352161 | 135590 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 505 | 11 | 0 | 9 | 5.7 | CCCCN(c1c(SC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCOCC1 | nan | |||
| CHEMBL3669430 | 135590 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 505 | 11 | 0 | 9 | 5.7 | CCCCN(c1c(SC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCOCC1 | nan | |||
| 71460919 | 89384 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 11 | 0 | 9 | 5.0 | COCc1cc(OC)c(-c2csc3c(N(CCC4CC4)C4CCOCC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| CHEMBL2179187 | 89384 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 11 | 0 | 9 | 5.0 | COCc1cc(OC)c(-c2csc3c(N(CCC4CC4)C4CCOCC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| 25150450 | 182722 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 510 | 3 | 1 | 7 | 5.4 | Cc1cc(-n2ccc(-c3nccs3)n2)c2[nH]c(=O)n(-c3ccc(C(F)(F)F)cc3C(F)(F)F)c2n1 | 10.1021/jm800743q | |||
| CHEMBL458780 | 182722 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 510 | 3 | 1 | 7 | 5.4 | Cc1cc(-n2ccc(-c3nccs3)n2)c2[nH]c(=O)n(-c3ccc(C(F)(F)F)cc3C(F)(F)F)c2n1 | 10.1021/jm800743q | |||
| 58896438 | 146280 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 350 | 7 | 1 | 4 | 5.6 | CCCN(CCC)c1cccc2nc(Nc3ccc(C)cc3C)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3793744 | 146280 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 350 | 7 | 1 | 4 | 5.6 | CCCN(CCC)c1cccc2nc(Nc3ccc(C)cc3C)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3794592 | 146280 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 350 | 7 | 1 | 4 | 5.6 | CCCN(CCC)c1cccc2nc(Nc3ccc(C)cc3C)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 56668634 | 71537 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 400 | 6 | 1 | 6 | 4.9 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4Cl)c(C)nn13)OCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819088 | 71537 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 400 | 6 | 1 | 6 | 4.9 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4Cl)c(C)nn13)OCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 68581422 | 181365 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 503 | 6 | 1 | 6 | 6.8 | COc1cc(Br)cc(C)c1Nc1nc2cccc(N(c3ccc(C#N)cc3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4556873 | 181365 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 503 | 6 | 1 | 6 | 6.8 | COc1cc(Br)cc(C)c1Nc1nc2cccc(N(c3ccc(C#N)cc3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| 44589257 | 181593 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 452 | 4 | 0 | 8 | 5.7 | N#Cc1cc(-c2cccs2)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| CHEMBL456241 | 181593 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 452 | 4 | 0 | 8 | 5.7 | N#Cc1cc(-c2cccs2)ccc1N1CCc2c(-n3ccc(-c4nccs4)n3)ccnc21 | 10.1021/jm800743q | |||
| 21912341 | 104731 | 1 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 341 | 7 | 0 | 3 | 6.2 | CCc1cc(OC(CC)CC)c(C)c(Oc2c(C)cc(C)cc2C)n1 | 10.1021/jm070578k | |||
| CHEMBL272619 | 104731 | 1 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 341 | 7 | 0 | 3 | 6.2 | CCc1cc(OC(CC)CC)c(C)c(Oc2c(C)cc(C)cc2C)n1 | 10.1021/jm070578k | |||
| 10160760 | 130848 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 444 | 6 | 0 | 5 | 5.1 | CCc1nc2c(n1COCc1ccccc1)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL363240 | 130848 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 444 | 6 | 0 | 5 | 5.1 | CCc1nc2c(n1COCc1ccccc1)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 58223395 | 134643 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 489 | 13 | 0 | 9 | 4.9 | COCc1cc(OC)c(-c2csc3c(N(CCC(C)OC)CC4CC4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664578 | 134643 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 489 | 13 | 0 | 9 | 4.9 | COCc1cc(OC)c(-c2csc3c(N(CCC(C)OC)CC4CC4)c(OC)nn23)c(OC)c1 | nan | |||
| 24768336 | 92303 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 414 | 9 | 1 | 7 | 4.1 | CCCN(CCOC)c1cc(C)nc2c1NCCN2c1cc(OC)c(OC)cc1C | 10.1021/jm0611410 | |||
| CHEMBL227503 | 92303 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 414 | 9 | 1 | 7 | 4.1 | CCCN(CCOC)c1cc(C)nc2c1NCCN2c1cc(OC)c(OC)cc1C | 10.1021/jm0611410 | |||
| 44589202 | 182735 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 438 | 3 | 0 | 7 | 5.0 | N#Cc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C(F)(F)F)c1 | 10.1021/jm800743q | |||
| CHEMBL458824 | 182735 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 438 | 3 | 0 | 7 | 5.0 | N#Cc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)c(C(F)(F)F)c1 | 10.1021/jm800743q | |||
| 21912341 | 104731 | 1 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 341 | 7 | 0 | 3 | 6.2 | CCc1cc(OC(CC)CC)c(C)c(Oc2c(C)cc(C)cc2C)n1 | 10.1021/jm070578k | |||
| CHEMBL272619 | 104731 | 1 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 341 | 7 | 0 | 3 | 6.2 | CCc1cc(OC(CC)CC)c(C)c(Oc2c(C)cc(C)cc2C)n1 | 10.1021/jm070578k | |||
| 44589303 | 182798 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 375 | 4 | 0 | 7 | 4.1 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)cc1 | 10.1021/jm800743q | |||
| CHEMBL458980 | 182798 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 375 | 4 | 0 | 7 | 4.1 | COc1ccc(N2CCc3c(-n4ccc(-c5nccs5)n4)ccnc32)cc1 | 10.1021/jm800743q | |||
| 10159424 | 129591 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 424 | 5 | 0 | 5 | 4.6 | CCc1nc2c(n1Cc1ccccc1C)C(=O)N(C)CN2c1ccc(OC)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL360532 | 129591 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 424 | 5 | 0 | 5 | 4.6 | CCc1nc2c(n1Cc1ccccc1C)C(=O)N(C)CN2c1ccc(OC)cc1Cl | 10.1021/jm049787k | |||
| 58223376 | 134677 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 513 | 11 | 0 | 9 | 4.7 | COCc1cc(OC)c(-c2csc3c(N(CC4CCC4)CC4C5COCC54)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664610 | 134677 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 513 | 11 | 0 | 9 | 4.7 | COCc1cc(OC)c(-c2csc3c(N(CC4CCC4)CC4C5COCC54)c(OC)nn23)c(OC)c1 | nan | |||
| 70682293 | 83383 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 436 | 10 | 0 | 5 | 6.3 | CCCN(CCC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| CHEMBL2063369 | 83383 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 436 | 10 | 0 | 5 | 6.3 | CCCN(CCC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| 70692846 | 83387 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 460 | 10 | 0 | 5 | 6.3 | COCc1cc(OC)c(-c2nc3c(C)ccc(N(CC4CC4)CC4CC4)c3cc2C)c(OC)c1 | 10.1016/j.bmcl.2012.07.047 | |||
| CHEMBL2063373 | 83387 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 460 | 10 | 0 | 5 | 6.3 | COCc1cc(OC)c(-c2nc3c(C)ccc(N(CC4CC4)CC4CC4)c3cc2C)c(OC)c1 | 10.1016/j.bmcl.2012.07.047 | |||
| 70682293 | 83383 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 436 | 10 | 0 | 5 | 6.3 | CCCN(CCC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2063369 | 83383 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 436 | 10 | 0 | 5 | 6.3 | CCCN(CCC)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 70688432 | 82677 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 375 | 7 | 1 | 3 | 6.8 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2049193 | 82677 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 375 | 7 | 1 | 3 | 6.8 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(C)cc12 | 10.1016/j.bmcl.2012.05.066 | |||
| 67117558 | 146731 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.6 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](CO)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3799741 | 146731 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 364 | 6 | 2 | 7 | 2.6 | COc1nc(C)c(Nc2nc(Cl)cn([C@H](CO)C3CC3)c2=O)cc1C | 10.1016/j.bmcl.2016.03.067 | |||
| 53357410 | 133316 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 360 | 4 | 1 | 4 | 3.8 | Cc1cc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)n1 | nan | |||
| CHEMBL3652116 | 133316 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 360 | 4 | 1 | 4 | 3.8 | Cc1cc(C)n(C[C@H]2CC[C@H](NC(=O)c3cc(Cl)cnc3C)CC2)n1 | nan | |||
| 58223512 | 134630 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 507 | 12 | 0 | 9 | 5.0 | CCOCc1cc(OC)c(-c2csc3c(N(CCCF)C4CCOCC4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664565 | 134630 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 507 | 12 | 0 | 9 | 5.0 | CCOCc1cc(OC)c(-c2csc3c(N(CCCF)C4CCOCC4)c(OC)nn23)c(OC)c1 | nan | |||
| 90654176 | 134666 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 515 | 12 | 0 | 9 | 5.3 | CCOc1nn2c(-c3c(OC)cc(COC)cc3OC)csc2c1N(CC1CCOCC1)CC1CC1 | nan | |||
| CHEMBL3664600 | 134666 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 515 | 12 | 0 | 9 | 5.3 | CCOc1nn2c(-c3c(OC)cc(COC)cc3OC)csc2c1N(CC1CCOCC1)CC1CC1 | nan | |||
| 58223489 | 135586 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 480 | 9 | 0 | 9 | 4.1 | COc1cc(C#N)cc(OC)c1-c1csc2c(N(CC3CC3)CC3C4COCC43)c(OC)nn12 | nan | |||
| CHEMBL3669427 | 135586 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 480 | 9 | 0 | 9 | 4.1 | COc1cc(C#N)cc(OC)c1-c1csc2c(N(CC3CC3)CC3C4COCC43)c(OC)nn12 | nan | |||
| 70684375 | 83388 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 424 | 9 | 0 | 6 | 4.8 | COCCN(C)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| CHEMBL2063374 | 83388 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 424 | 9 | 0 | 6 | 4.8 | COCCN(C)c1ccc(C)c2nc(-c3c(OC)cc(COC)cc3OC)c(C)cc12 | 10.1016/j.bmcl.2012.07.047 | |||
| 145967853 | 171783 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 410 | 3 | 1 | 5 | 5.8 | CCN(O)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL4225843 | 171783 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 410 | 3 | 1 | 5 | 5.8 | CCN(O)c1ccc(Cl)c2nc3n(c12)CCCN3c1ccc(Cl)cc1Cl | 10.1016/j.bmc.2018.01.020 | |||
| 44589318 | 184464 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 494 | 3 | 1 | 6 | 4.8 | Cc1cc(-n2ccc(-n3cc[nH]c3=O)n2)c2c(n1)N(c1ccc(C(F)(F)F)cc1C(F)(F)F)CC2 | 10.1021/jm800744m | |||
| CHEMBL464185 | 184464 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 494 | 3 | 1 | 6 | 4.8 | Cc1cc(-n2ccc(-n3cc[nH]c3=O)n2)c2c(n1)N(c1ccc(C(F)(F)F)cc1C(F)(F)F)CC2 | 10.1021/jm800744m | |||
| 145955820 | 169453 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 355 | 4 | 1 | 6 | 4.0 | CCN(CC)c1nc(C)nc2c1sc(=N)n2-c1c(C)cc(C)cc1C | 10.1016/j.ejmech.2017.07.016 | |||
| CHEMBL4170184 | 169453 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 355 | 4 | 1 | 6 | 4.0 | CCN(CC)c1nc(C)nc2c1sc(=N)n2-c1c(C)cc(C)cc1C | 10.1016/j.ejmech.2017.07.016 | |||
| 10272004 | 173023 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 394 | 6 | 0 | 4 | 5.5 | CCCC(CCC)n1cnc2c1C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL426791 | 173023 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 394 | 6 | 0 | 4 | 5.5 | CCCC(CCC)n1cnc2c1C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 10111139 | 71526 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 392 | 6 | 1 | 5 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4c(C)cc(OC)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819076 | 71526 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 392 | 6 | 1 | 5 | 5.4 | CCC(CC)Nc1c2c(nc3c(-c4c(C)cc(OC)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 9819381 | 104474 | 3 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 341 | 7 | 0 | 3 | 6.2 | CCc1c(OC(CC)CC)cc(C)nc1Oc1c(C)cc(C)cc1C | 10.1021/jm070578k | |||
| CHEMBL271324 | 104474 | 3 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 341 | 7 | 0 | 3 | 6.2 | CCc1c(OC(CC)CC)cc(C)nc1Oc1c(C)cc(C)cc1C | 10.1021/jm070578k | |||
| 9819381 | 104474 | 3 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 341 | 7 | 0 | 3 | 6.2 | CCc1c(OC(CC)CC)cc(C)nc1Oc1c(C)cc(C)cc1C | 10.1021/jm070578k | |||
| CHEMBL271324 | 104474 | 3 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 341 | 7 | 0 | 3 | 6.2 | CCc1c(OC(CC)CC)cc(C)nc1Oc1c(C)cc(C)cc1C | 10.1021/jm070578k | |||
| 58280029 | 146534 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 528 | 9 | 2 | 10 | 4.6 | COc1ccc(NC(=O)OC[C@H](C2CC2)n2cc(Cl)nc(Nc3cc(C)c(OC)nc3C)c2=O)c(C)n1 | 10.1016/j.bmcl.2016.03.067 | |||
| CHEMBL3798497 | 146534 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 528 | 9 | 2 | 10 | 4.6 | COc1ccc(NC(=O)OC[C@H](C2CC2)n2cc(Cl)nc(Nc3cc(C)c(OC)nc3C)c2=O)c(C)n1 | 10.1016/j.bmcl.2016.03.067 | |||
| 46891158 | 13266 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 337 | 5 | 1 | 6 | 3.5 | CCC(C1CC1)n1nc(C)nc(Nc2cc(C)c(C#N)cc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082706 | 13266 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 337 | 5 | 1 | 6 | 3.5 | CCC(C1CC1)n1nc(C)nc(Nc2cc(C)c(C#N)cc2C)c1=O | 10.1016/j.bmcl.2010.04.121 | |||
| 44190243 | 202882 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 351 | 5 | 1 | 4 | 5.0 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cccc2Cl)c1=O | 10.1021/jm900301y | |||
| CHEMBL560896 | 202882 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 351 | 5 | 1 | 4 | 5.0 | CC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)cccc2Cl)c1=O | 10.1021/jm900301y | |||
| 70909805 | 146092 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 434 | 8 | 1 | 5 | 6.6 | CCCN(CCC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3792517 | 146092 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 434 | 8 | 1 | 5 | 6.6 | CCCN(CCC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 70909805 | 146092 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 434 | 8 | 1 | 5 | 6.6 | CCCN(CCC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| CHEMBL3792517 | 146092 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 434 | 8 | 1 | 5 | 6.6 | CCCN(CCC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2016.11.011 | |||
| 127030314 | 146167 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 406 | 6 | 1 | 5 | 5.8 | CCN(CC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2018.01.020 | |||
| CHEMBL3793277 | 146167 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 406 | 6 | 1 | 5 | 5.8 | CCN(CC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12 | 10.1016/j.bmc.2018.01.020 | |||
| 57392001 | 76762 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 367 | 6 | 0 | 5 | 4.7 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| CHEMBL1939582 | 76762 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 367 | 6 | 0 | 5 | 4.7 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC)c(=O)c12 | 10.1016/j.bmc.2011.11.015 | |||
| 42618174 | 200113 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 385 | 8 | 1 | 8 | 2.8 | COCC(COC)Nc1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| CHEMBL524616 | 200113 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 385 | 8 | 1 | 8 | 2.8 | COCC(COC)Nc1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm9000242 | |||
| 24768324 | 104436 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 391 | 6 | 0 | 3 | 6.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1Br | 10.1021/jm070578k | |||
| CHEMBL271125 | 104436 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 391 | 6 | 0 | 3 | 6.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1Br | 10.1021/jm070578k | |||
| 9820041 | 165011 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 355 | 8 | 0 | 3 | 6.6 | CCCc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1 | 10.1021/jm070578k | |||
| CHEMBL408824 | 165011 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 355 | 8 | 0 | 3 | 6.6 | CCCc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1 | 10.1021/jm070578k | |||
| 24768324 | 104436 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 391 | 6 | 0 | 3 | 6.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1Br | 10.1021/jm070578k | |||
| CHEMBL271125 | 104436 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 391 | 6 | 0 | 3 | 6.4 | CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1Br | 10.1021/jm070578k | |||
| 9820041 | 165011 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 355 | 8 | 0 | 3 | 6.6 | CCCc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1 | 10.1021/jm070578k | |||
| CHEMBL408824 | 165011 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 355 | 8 | 0 | 3 | 6.6 | CCCc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1 | 10.1021/jm070578k | |||
| 24768334 | 151356 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 386 | 8 | 1 | 8 | 3.4 | CCCCN(CC)c1nc(C)nc2c1NCCN2c1ccc(OC)nc1OC | 10.1021/jm0611410 | |||
| CHEMBL390763 | 151356 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 386 | 8 | 1 | 8 | 3.4 | CCCCN(CC)c1nc(C)nc2c1NCCN2c1ccc(OC)nc1OC | 10.1021/jm0611410 | |||
| 46891089 | 13592 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 404 | 6 | 1 | 6 | 4.6 | Cc1nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1083946 | 13592 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 404 | 6 | 1 | 6 | 4.6 | Cc1nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c(=O)n(C(C)C2CC2)n1 | 10.1016/j.bmcl.2010.04.121 | |||
| 70690481 | 82680 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 429 | 6 | 1 | 4 | 6.6 | Cc1cc(C)c(Nc2nc3cccc(N(CC4CC4)C4CCOCC4)c3cc2C)c(C)c1 | 10.1016/j.bmcl.2012.05.066 | |||
| CHEMBL2049196 | 82680 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 429 | 6 | 1 | 4 | 6.6 | Cc1cc(C)c(Nc2nc3cccc(N(CC4CC4)C4CCOCC4)c3cc2C)c(C)c1 | 10.1016/j.bmcl.2012.05.066 | |||
| 58801667 | 84339 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 481 | 11 | 0 | 7 | 5.4 | CCCN(CC1CCOCC1)c1c(CC)nn2c(-c3c(OC)cc(COC)cc3OC)cccc12 | 10.1021/jm300259r | |||
| CHEMBL2087572 | 84339 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 481 | 11 | 0 | 7 | 5.4 | CCCN(CC1CCOCC1)c1c(CC)nn2c(-c3c(OC)cc(COC)cc3OC)cccc12 | 10.1021/jm300259r | |||
| 46881866 | 14784 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 395 | 8 | 1 | 9 | 2.4 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)nc(OC)nc2OC)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| CHEMBL1090740 | 14784 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 395 | 8 | 1 | 9 | 2.4 | COC[C@H](C1CC1)n1cc(Cl)nc(Nc2c(C)nc(OC)nc2OC)c1=O | 10.1016/j.bmcl.2010.01.129 | |||
| 58896512 | 179756 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 556 | 7 | 1 | 7 | 6.3 | COc1cc(Br)cc(C)c1Nc1nc2cccc(N(c3cccc(S(C)(=O)=O)c3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| CHEMBL4517763 | 179756 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 556 | 7 | 1 | 7 | 6.3 | COc1cc(Br)cc(C)c1Nc1nc2cccc(N(c3cccc(S(C)(=O)=O)c3)C(C)C)c2n1C | 10.1016/j.bmc.2016.08.005 | |||
| 10205141 | 70239 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 464 | 4 | 0 | 4 | 6.1 | CCc1nc2c(n1Cc1cccc3ccccc13)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| CHEMBL179826 | 70239 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 464 | 4 | 0 | 4 | 6.1 | CCc1nc2c(n1Cc1cccc3ccccc13)C(=O)N(C)CN2c1ccc(Cl)cc1Cl | 10.1021/jm049787k | |||
| 71453736 | 89387 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 489 | 10 | 0 | 9 | 4.9 | COCc1cc(OC)c(-c2csc3c(N(CC(C)C)C4CCOCC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| CHEMBL2179190 | 89387 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 489 | 10 | 0 | 9 | 4.9 | COCc1cc(OC)c(-c2csc3c(N(CC(C)C)C4CCOCC4)c(OC)nn23)c(OC)c1 | 10.1021/jm300864p | |||
| 42618215 | 190873 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 413 | 9 | 0 | 9 | 2.3 | COCCN(CCOC)c1nc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm900025h | |||
| CHEMBL482544 | 190873 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 413 | 9 | 0 | 9 | 2.3 | COCCN(CCOC)c1nc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm900025h | |||
| 44190338 | 202902 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 453 | 9 | 1 | 6 | 5.4 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OCc3ccccc3)cc2C)c1=O | 10.1021/jm900301y | |||
| CHEMBL561034 | 202902 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 453 | 9 | 1 | 6 | 5.4 | COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OCc3ccccc3)cc2C)c1=O | 10.1021/jm900301y | |||
| 51352160 | 134613 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 503 | 11 | 0 | 10 | 4.1 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4COCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664548 | 134613 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 503 | 11 | 0 | 10 | 4.1 | COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4COCOC4)c(OC)nn23)c(OC)c1 | nan | |||
| 10377 | 7962 | 27 | None | -1 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2011.02.086 | |||
| 9818802 | 7962 | 27 | None | -1 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2011.02.086 | |||
| CHEMBL270738 | 7962 | 27 | None | -1 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2011.02.086 | |||
| 11280845 | 133614 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 3.9 | CCN(CCCC#N)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)cc1C | 10.1021/jm049737f | |||
| CHEMBL365511 | 133614 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 393 | 7 | 1 | 6 | 3.9 | CCN(CCCC#N)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)cc1C | 10.1021/jm049737f | |||
| 58223470 | 134608 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 563 | 12 | 0 | 10 | 6.3 | COCc1cc(OC)c(-c2c(SC)sc3c(N(CC4CCOCC4)CC4CC4)c(SC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664543 | 134608 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 563 | 12 | 0 | 10 | 6.3 | COCc1cc(OC)c(-c2c(SC)sc3c(N(CC4CCOCC4)CC4CC4)c(SC)nn23)c(OC)c1 | nan | |||
| 23567868 | 71522 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 366 | 5 | 1 | 4 | 5.2 | CCC(CC)Nc1c2c(nc3c(-c4ccc(F)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819072 | 71522 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 366 | 5 | 1 | 4 | 5.2 | CCC(CC)Nc1c2c(nc3c(-c4ccc(F)cc4C)c(C)nn13)CCC2 | 10.1016/j.bmc.2011.07.055 | |||
| 44589348 | 182805 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 432 | 3 | 0 | 6 | 4.9 | N#Cc1ccc(N2CCc3c(-n4ccc(-c5ccccn5)n4)ccnc32)c(C(F)(F)F)c1 | 10.1021/jm800743q | |||
| CHEMBL459006 | 182805 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 432 | 3 | 0 | 6 | 4.9 | N#Cc1ccc(N2CCc3c(-n4ccc(-c5ccccn5)n4)ccnc32)c(C(F)(F)F)c1 | 10.1021/jm800743q | |||
| 46891190 | 13198 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 339 | 5 | 1 | 7 | 2.9 | COc1cc(Nc2nc(C)nn(C(C)C3CC3)c2=O)c(C)cc1C#N | 10.1016/j.bmcl.2010.04.121 | |||
| CHEMBL1082401 | 13198 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 339 | 5 | 1 | 7 | 2.9 | COc1cc(Nc2nc(C)nn(C(C)C3CC3)c2=O)c(C)cc1C#N | 10.1016/j.bmcl.2010.04.121 | |||
| 67363460 | 137368 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 468 | 7 | 3 | 3 | 5.4 | O=C(O)Cc1ccc(NC[C@H]2CC[C@@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)cc1 | nan | |||
| CHEMBL3681373 | 137368 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 468 | 7 | 3 | 3 | 5.4 | O=C(O)Cc1ccc(NC[C@H]2CC[C@@H](NC(=O)c3cc(C(F)(F)F)ccc3Cl)CC2)cc1 | nan | |||
| 58223507 | 134631 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 537 | 11 | 0 | 9 | 5.1 | COCc1cc(OC)c(-c2csc3c(N(CC4CCOC4)CC4CC(F)(F)C4)c(OC)nn23)c(OC)c1 | nan | |||
| CHEMBL3664566 | 134631 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 537 | 11 | 0 | 9 | 5.1 | COCc1cc(OC)c(-c2csc3c(N(CC4CCOC4)CC4CC(F)(F)C4)c(OC)nn23)c(OC)c1 | nan | |||
| 24768330 | 92351 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 383 | 7 | 1 | 6 | 3.8 | CCCCN(CC)c1nc(C)nc2c1NC(=O)CN2c1ccc(OC)cc1C | 10.1021/jm0611410 | |||
| CHEMBL228110 | 92351 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 383 | 7 | 1 | 6 | 3.8 | CCCCN(CC)c1nc(C)nc2c1NC(=O)CN2c1ccc(OC)cc1C | 10.1021/jm0611410 | |||
| 53357797 | 137388 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 449 | 5 | 2 | 4 | 4.7 | O=C(N[C@H]1CC[C@H](Cn2cc(Cl)c(CO)n2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | |||
| CHEMBL3681393 | 137388 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 449 | 5 | 2 | 4 | 4.7 | O=C(N[C@H]1CC[C@H](Cn2cc(Cl)c(CO)n2)CC1)c1cc(C(F)(F)F)ccc1Cl | nan | |||
| 58896424 | 146192 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 392 | 8 | 1 | 4 | 6.9 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)n(C(C)C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3793781 | 146192 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 392 | 8 | 1 | 4 | 6.9 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)n(C(C)C)c12 | 10.1021/acs.jmedchem.5b01715 | |||
| 22178115 | 71517 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 392 | 7 | 1 | 5 | 5.4 | CCc1nn2c(NC(CC)CC)c3c(nc2c1-c1ccc(OC)cc1C)CCC3 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL1819067 | 71517 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 392 | 7 | 1 | 5 | 5.4 | CCc1nn2c(NC(CC)CC)c3c(nc2c1-c1ccc(OC)cc1C)CCC3 | 10.1016/j.bmc.2011.07.055 | |||
| 54580961 | 67424 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 408 | 8 | 0 | 5 | 5.3 | CCCCN(CCCC)c1nc2c(c(-c3c(C)cc(C)cc3C)cn2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| CHEMBL1760254 | 67424 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 408 | 8 | 0 | 5 | 5.3 | CCCCN(CCCC)c1nc2c(c(-c3c(C)cc(C)cc3C)cn2C)c(=O)n1C | 10.1016/j.bmcl.2011.02.086 | |||
| 60155889 | 84350 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 527 | 11 | 1 | 9 | 4.6 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4(O)CC4)c(SC)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| CHEMBL2087797 | 84350 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 527 | 11 | 1 | 9 | 4.6 | COCc1cc(OC)c(-c2cccc3c(N(CC4CCOCC4)CC4(O)CC4)c(SC)nn23)c(OC)c1 | 10.1021/jm300259r | |||
| 57912441 | 89383 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 475 | 10 | 0 | 9 | 4.6 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| CHEMBL2179186 | 89383 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 475 | 10 | 0 | 9 | 4.6 | CCCN(c1c(OC)nn2c(-c3c(OC)cc(COC)cc3OC)csc12)C1CCOCC1 | 10.1021/jm300864p | |||
| 58223406 | 135587 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 468 | 9 | 0 | 9 | 4.1 | CCCN(CC1C2COCC21)c1c(OC)nn2c(-c3c(OC)cc(C#N)cc3OC)csc12 | nan | |||
| CHEMBL3669428 | 135587 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 468 | 9 | 0 | 9 | 4.1 | CCCN(CC1C2COCC21)c1c(OC)nn2c(-c3c(OC)cc(C#N)cc3OC)csc12 | nan | |||
| 71456848 | 88285 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 394 | 7 | 0 | 5 | 5.4 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(C)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| CHEMBL2160159 | 88285 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 394 | 7 | 0 | 5 | 5.4 | CCN(CC)c1ccc(OC)c2nc(-c3c(OC)cc(C)cc3OC)c(C)cc12 | 10.1016/j.bmc.2012.09.028 | |||
| 58896475 | 146144 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 351 | 7 | 1 | 4 | 6.1 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)oc12 | 10.1021/acs.jmedchem.5b01715 | |||
| CHEMBL3793059 | 146144 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 351 | 7 | 1 | 4 | 6.1 | CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)oc12 | 10.1021/acs.jmedchem.5b01715 | |||
| 9884878 | 179804 | 18 | None | - | 1 | Human | 9.6 | pKd | = | 9.6 | Binding | ChEMBL | 352 | 6 | 1 | 5 | 4.9 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1016/j.bmcl.2011.08.040 | |||
| CHEMBL45187 | 179804 | 18 | None | - | 1 | Human | 9.6 | pKd | = | 9.6 | Binding | ChEMBL | 352 | 6 | 1 | 5 | 4.9 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1016/j.bmcl.2011.08.040 | |||
| 54591779 | 72804 | 0 | None | - | 1 | Human | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 429 | 8 | 1 | 7 | 4.6 | COc1cc(OC(F)F)ccc1-n1c(C)nc2c(NC(C3CC3)C3CC3)nc(C)nc21 | 10.1016/j.bmcl.2011.08.040 | |||
| CHEMBL1836947 | 72804 | 0 | None | - | 1 | Human | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 429 | 8 | 1 | 7 | 4.6 | COc1cc(OC(F)F)ccc1-n1c(C)nc2c(NC(C3CC3)C3CC3)nc(C)nc21 | 10.1016/j.bmcl.2011.08.040 | |||
| 3520 | 10041 | 54 | None | 1 | 2 | Human | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2011.08.040 | |||
| 9821250 | 10041 | 54 | None | 1 | 2 | Human | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2011.08.040 | |||
| CHEMBL309138 | 10041 | 54 | None | 1 | 2 | Human | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2011.08.040 | |||
| 44545165 | 72802 | 0 | None | - | 1 | Human | 9.4 | pKd | = | 9.4 | Binding | ChEMBL | 433 | 7 | 1 | 6 | 5.3 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(OC(F)F)cc3Cl)c2n1 | 10.1016/j.bmcl.2011.08.040 | |||
| CHEMBL1836945 | 72802 | 0 | None | - | 1 | Human | 9.4 | pKd | = | 9.4 | Binding | ChEMBL | 433 | 7 | 1 | 6 | 5.3 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(OC(F)F)cc3Cl)c2n1 | 10.1016/j.bmcl.2011.08.040 | |||
| 54591854 | 72789 | 0 | None | - | 1 | Human | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 363 | 6 | 1 | 6 | 4.0 | COc1ccc(-n2c(C)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)cc1 | 10.1016/j.bmcl.2011.08.040 | |||
| CHEMBL1836932 | 72789 | 0 | None | - | 1 | Human | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 363 | 6 | 1 | 6 | 4.0 | COc1ccc(-n2c(C)nc3c(NC(C4CC4)C4CC4)nc(C)nc32)cc1 | 10.1016/j.bmcl.2011.08.040 | |||
| 45485040 | 204063 | 0 | None | - | 1 | Human | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 383 | 8 | 0 | 7 | 3.6 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2011.08.040 | |||
| CHEMBL568606 | 204063 | 0 | None | - | 1 | Human | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 383 | 8 | 0 | 7 | 3.6 | CCCN(CCOC)c1nc(C)nc2c1c(C)nn2-c1ccc(OC)cc1C | 10.1016/j.bmcl.2011.08.040 | |||
| 44545161 | 72801 | 0 | None | - | 1 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 399 | 7 | 1 | 6 | 4.6 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(OC(F)F)cc3)c2n1 | 10.1016/j.bmcl.2011.08.040 | |||
| CHEMBL1836944 | 72801 | 0 | None | - | 1 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 399 | 7 | 1 | 6 | 4.6 | Cc1nc(NC(C2CC2)C2CC2)c2nc(C)n(-c3ccc(OC(F)F)cc3)c2n1 | 10.1016/j.bmcl.2011.08.040 | |||
| CHEMBL4299295 | 220341 | 0 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(=O)O)NC(C)=O)[C@H](C)O)C(C)C)C(=O)N[C@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||||
| 127033542 | 145400 | 0 | None | 2 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 3960 | 128 | 56 | 50 | -10.4 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3775796 | 145400 | 0 | None | 2 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 3960 | 128 | 56 | 50 | -10.4 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| 127032315 | 145206 | 0 | None | 1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 3880 | 126 | 55 | 49 | -10.4 | CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3774395 | 145206 | 0 | None | 1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 3880 | 126 | 55 | 49 | -10.4 | CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL4299341 | 220349 | 0 | None | -1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1CCC(=O)NCCCC[C@H](C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C(N)=O)[C@H](C)CC)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](C)NC1=O | 10.1021/acs.jmedchem.5b00926 | |||||
| 11546255 | 194896 | 0 | None | 12022 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 419 | 5 | 0 | 7 | 4.9 | CCC(CC)c1cc(C)nn2c(-c3sc(N4CCOCC4)nc3Cl)c(C)nc12 | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL498311 | 194896 | 0 | None | 12022 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 419 | 5 | 0 | 7 | 4.9 | CCC(CC)c1cc(C)nn2c(-c3sc(N4CCOCC4)nc3Cl)c(C)nc12 | 10.1016/j.bmcl.2008.07.063 | |||
| 127031741 | 145274 | 0 | None | 1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 4028 | 129 | 57 | 50 | -9.6 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3774868 | 145274 | 0 | None | 1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 4028 | 129 | 57 | 50 | -9.6 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| 127033842 | 145295 | 0 | None | 8 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 4000 | 127 | 56 | 51 | -10.2 | CCCCC(NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2cccs2)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3775030 | 145295 | 0 | None | 8 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 4000 | 127 | 56 | 51 | -10.2 | CCCCC(NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2cccs2)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O | 10.1021/acs.jmedchem.5b00926 | |||
| 127032010 | 145249 | 0 | None | 9 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 4000 | 127 | 56 | 51 | -10.2 | CCCCC(NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2ccsc2)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3774682 | 145249 | 0 | None | 9 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 4000 | 127 | 56 | 51 | -10.2 | CCCCC(NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2ccsc2)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O | 10.1021/acs.jmedchem.5b00926 | |||
| 127032315 | 145206 | 0 | None | 1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 3880 | 126 | 55 | 49 | -10.4 | CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3774395 | 145206 | 0 | None | 1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 3880 | 126 | 55 | 49 | -10.4 | CCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL4299349 | 220351 | 0 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(=O)O)NC(C)=O)[C@H](C)O)C(C)C)C(=O)N[C@H](C)C(=O)N[C@@](C)(CC(C)C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||||
| CHEMBL4299348 | 220350 | 0 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(=O)O)NC(C)=O)[C@H](C)O)C(C)C)C(=O)N[C@H](C)C(=O)NC(C)(CC(C)C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||||
| 127033542 | 145400 | 0 | None | 2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 3960 | 128 | 56 | 50 | -10.4 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3775796 | 145400 | 0 | None | 2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 3960 | 128 | 56 | 50 | -10.4 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| 127031439 | 145377 | 0 | None | 5 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 3994 | 127 | 56 | 50 | -10.3 | CCCCC(NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3775621 | 145377 | 0 | None | 5 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 3994 | 127 | 56 | 50 | -10.3 | CCCCC(NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL4299340 | 220348 | 0 | None | -1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC(=O)C(CCCC)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N1)C(=O)N[C@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C(N)=O)[C@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||||
| 10111093 | 125529 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCCN(CC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| CHEMBL341820 | 125529 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCCN(CC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| 127031736 | 145384 | 0 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 3876 | 124 | 56 | 50 | -12.4 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3775678 | 145384 | 0 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 3876 | 124 | 56 | 50 | -12.4 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| 127032314 | 145398 | 0 | None | -1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 3902 | 125 | 55 | 49 | -10.2 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](C)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3775778 | 145398 | 0 | None | -1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 3902 | 125 | 55 | 49 | -10.2 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](C)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL4299352 | 220352 | 0 | None | 2 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||||
| CHEMBL4299286 | 220338 | 0 | None | 2 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(Cc1ccccc1)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||||
| CHEMBL4299295 | 220341 | 0 | None | 1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(=O)O)NC(C)=O)[C@H](C)O)C(C)C)C(=O)N[C@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||||
| 127031441 | 145354 | 0 | None | 1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 3900 | 124 | 55 | 49 | -10.7 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3775437 | 145354 | 0 | None | 1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 3900 | 124 | 55 | 49 | -10.7 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| 127033544 | 145403 | 0 | None | 2 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 4044 | 127 | 56 | 50 | -9.1 | CCCCC(NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3775812 | 145403 | 0 | None | 2 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 4044 | 127 | 56 | 50 | -9.1 | CCCCC(NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O | 10.1021/acs.jmedchem.5b00926 | |||
| 9908879 | 16852 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 398 | 6 | 0 | 2 | 7.1 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL115389 | 16852 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 398 | 6 | 0 | 2 | 7.1 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 127031132 | 145241 | 0 | None | 7 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 4044 | 127 | 56 | 50 | -9.1 | CCCCC(NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2cccc3ccccc23)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3774594 | 145241 | 0 | None | 7 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 4044 | 127 | 56 | 50 | -9.1 | CCCCC(NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2cccc3ccccc23)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O | 10.1021/acs.jmedchem.5b00926 | |||
| 127031129 | 145395 | 0 | None | -1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 3936 | 130 | 55 | 49 | -8.8 | CCCCCCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3775761 | 145395 | 0 | None | -1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 3936 | 130 | 55 | 49 | -8.8 | CCCCCCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL4299308 | 220343 | 0 | None | 1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC(=O)C(CCCC)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C(N)=O)[C@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||||
| 127029856 | 145318 | 0 | None | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 3866 | 125 | 55 | 49 | -10.8 | CCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3775192 | 145318 | 0 | None | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 3866 | 125 | 55 | 49 | -10.8 | CCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| 10715520 | 126114 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCN(CCC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| CHEMBL344223 | 126114 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCN(CCC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| 127030817 | 145285 | 0 | None | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 3824 | 122 | 55 | 49 | -12.0 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3774939 | 145285 | 0 | None | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 3824 | 122 | 55 | 49 | -12.0 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| 9909978 | 16810 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 418 | 8 | 0 | 4 | 6.7 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL115142 | 16810 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 418 | 8 | 0 | 4 | 6.7 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| 9909978 | 16810 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 418 | 8 | 0 | 4 | 6.7 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL115142 | 16810 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 418 | 8 | 0 | 4 | 6.7 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 127031129 | 145395 | 0 | None | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 3936 | 130 | 55 | 49 | -8.8 | CCCCCCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3775761 | 145395 | 0 | None | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 3936 | 130 | 55 | 49 | -8.8 | CCCCCCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| 127033847 | 145268 | 0 | None | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 3880 | 124 | 55 | 49 | -10.7 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C(=O)N[C@H](C(N)=O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3774836 | 145268 | 0 | None | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 3880 | 124 | 55 | 49 | -10.7 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C(=O)N[C@H](C(N)=O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b00926 | |||
| 127029856 | 145318 | 0 | None | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 3866 | 125 | 55 | 49 | -10.8 | CCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3775192 | 145318 | 0 | None | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 3866 | 125 | 55 | 49 | -10.8 | CCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| 127031738 | 145224 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 3903 | 125 | 55 | 49 | -9.6 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3774485 | 145224 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 3903 | 125 | 55 | 49 | -9.6 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| 127031126 | 145256 | 0 | None | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 3838 | 123 | 55 | 49 | -11.6 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)CC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3774742 | 145256 | 0 | None | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 3838 | 123 | 55 | 49 | -11.6 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)CC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL4299297 | 220342 | 0 | None | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C(=O)N[C@H](C(N)=O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b00926 | |||||
| 10294626 | 38908 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 403 | 6 | 0 | 5 | 5.3 | CCCN(CC1CC1)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| CHEMBL140894 | 38908 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 403 | 6 | 0 | 5 | 5.3 | CCCN(CC1CC1)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| 44347388 | 121329 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 434 | 7 | 0 | 5 | 6.4 | CCCN(CC1CC1)c1cc(SC)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL333735 | 121329 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 434 | 7 | 0 | 5 | 6.4 | CCCN(CC1CC1)c1cc(SC)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 127033848 | 145221 | 0 | None | -2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 3852 | 124 | 55 | 49 | -11.2 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)CCC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3774465 | 145221 | 0 | None | -2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 3852 | 124 | 55 | 49 | -11.2 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)CCC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL4299286 | 220338 | 0 | None | 2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(Cc1ccccc1)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||||
| CHEMBL4299340 | 220348 | 0 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC(=O)C(CCCC)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N1)C(=O)N[C@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C(N)=O)[C@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||||
| 44392711 | 130324 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 437 | 6 | 0 | 5 | 5.7 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ncc(C(F)(F)F)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL361782 | 130324 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 437 | 6 | 0 | 5 | 5.7 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ncc(C(F)(F)F)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 10552787 | 127513 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 480 | 7 | 1 | 6 | 5.4 | CCCC(CCC)Nc1nc(C)nc2c1nnn2-c1ccc(Br)cc1Br | 10.1021/jm980224g | |||
| CHEMBL354886 | 127513 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 480 | 7 | 1 | 6 | 5.4 | CCCC(CCC)Nc1nc(C)nc2c1nnn2-c1ccc(Br)cc1Br | 10.1021/jm980224g | |||
| CHEMBL439883 | 220628 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1016/j.bmcl.2015.10.010 | |||||
| CHEMBL439883 | 220628 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O | 10.1016/j.bmcl.2015.10.010 | |||||
| 127033261 | 145252 | 0 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 3992 | 134 | 55 | 49 | -7.3 | CCCCCCCCCCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3774713 | 145252 | 0 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 3992 | 134 | 55 | 49 | -7.3 | CCCCCCCCCCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| 177990 | 7214 | 23 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1021/jm980224g | |||
| 3489 | 7214 | 23 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1021/jm980224g | |||
| CHEMBL296641 | 7214 | 23 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1021/jm980224g | |||
| 10694584 | 65506 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 443 | 7 | 0 | 5 | 5.9 | CCCCN(CC)c1nc(C)nc2c1nc(C)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL168554 | 65506 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 443 | 7 | 0 | 5 | 5.9 | CCCCN(CC)c1nc(C)nc2c1nc(C)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 10388138 | 16771 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 7.0 | CCCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL114912 | 16771 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 7.0 | CCCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 9821586 | 174882 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL432800 | 174882 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 9821586 | 174882 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL432800 | 174882 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 10251024 | 175195 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 410 | 8 | 0 | 4 | 6.2 | CCCN(CCCCF)c1nc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(00)00071-8 | |||
| CHEMBL434882 | 175195 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 410 | 8 | 0 | 4 | 6.2 | CCCN(CCCCF)c1nc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(00)00071-8 | |||
| CHEMBL4299335 | 220347 | 0 | None | -1 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(Cc1ccccc1)C(=O)N[C@@H](C(N)=O)[C@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||||
| 177990 | 7214 | 23 | None | 1 | 2 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1021/jm034077k | |||
| 3489 | 7214 | 23 | None | 1 | 2 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1021/jm034077k | |||
| CHEMBL296641 | 7214 | 23 | None | 1 | 2 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1021/jm034077k | |||
| 44341921 | 17066 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 444 | 9 | 0 | 4 | 7.0 | CCCCCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL116171 | 17066 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 444 | 9 | 0 | 4 | 7.0 | CCCCCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 9998661 | 64722 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 360 | 3 | 0 | 4 | 4.4 | COc1cc(Br)c(-n2ccc3c(C)cc(C)nc32)c(OC)c1 | 10.1021/jm980223o | |||
| CHEMBL167241 | 64722 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 360 | 3 | 0 | 4 | 4.4 | COc1cc(Br)c(-n2ccc3c(C)cc(C)nc32)c(OC)c1 | 10.1021/jm980223o | |||
| 9884878 | 179804 | 18 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 352 | 6 | 1 | 5 | 4.9 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm990590f | |||
| CHEMBL45187 | 179804 | 18 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 352 | 6 | 1 | 5 | 4.9 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1021/jm990590f | |||
| 9884878 | 179804 | 18 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 352 | 6 | 1 | 5 | 4.9 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1016/j.ejmech.2016.11.019 | |||
| CHEMBL45187 | 179804 | 18 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 352 | 6 | 1 | 5 | 4.9 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1016/j.ejmech.2016.11.019 | |||
| 10428930 | 210466 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 365 | 6 | 0 | 5 | 4.9 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(C)cc3C)nn(C)c12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL67484 | 210466 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 365 | 6 | 0 | 5 | 4.9 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(C)cc3C)nn(C)c12 | 10.1016/s0960-894x(02)00358-x | |||
| 9822241 | 70783 | 8 | None | 9 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 399 | 8 | 1 | 6 | 5.0 | CCC(CC)Nc1nc(C)c(-c2ccc(OC(F)(F)F)cc2OC)nc1OC | 10.1021/jm200365y | |||
| CHEMBL1807053 | 70783 | 8 | None | 9 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 399 | 8 | 1 | 6 | 5.0 | CCC(CC)Nc1nc(C)c(-c2ccc(OC(F)(F)F)cc2OC)nc1OC | 10.1021/jm200365y | |||
| 9884878 | 179804 | 18 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 352 | 6 | 1 | 5 | 4.9 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL45187 | 179804 | 18 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 352 | 6 | 1 | 5 | 4.9 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1016/j.bmc.2011.07.055 | |||
| CHEMBL2373995 | 217161 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)N[C@@H](CC(=O)O)C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CC(N)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm990590f | |||||
| CHEMBL4299314 | 220345 | 0 | None | -1 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1CCC(=O)NCCCC[C@H](C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C(N)=O)[C@H](C)CC)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](C)NC1=O | 10.1021/acs.jmedchem.5b00926 | |||||
| 9913240 | 74722 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 484 | 7 | 0 | 5 | 6.2 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(C(C)C)cc3Br)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL191090 | 74722 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 484 | 7 | 0 | 5 | 6.2 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(C(C)C)cc3Br)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 44392663 | 72295 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 453 | 8 | 0 | 5 | 6.5 | CCCCN(CCCC)c1cc(C)nc2c(-c3ncc(C(F)(F)F)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL183068 | 72295 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 453 | 8 | 0 | 5 | 6.5 | CCCCN(CCCC)c1cc(C)nc2c(-c3ncc(C(F)(F)F)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 44290322 | 107947 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 382 | 8 | 0 | 6 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL295563 | 107947 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 382 | 8 | 0 | 6 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 23595022 | 70788 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 363 | 8 | 1 | 5 | 5.0 | CCc1nc(-c2ccc(OC)cc2Cl)c(OC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1807058 | 70788 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 363 | 8 | 1 | 5 | 5.0 | CCc1nc(-c2ccc(OC)cc2Cl)c(OC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 10667354 | 123378 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 377 | 5 | 1 | 5 | 5.3 | CCC(CC)Nc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| CHEMBL336678 | 123378 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 377 | 5 | 1 | 5 | 5.3 | CCC(CC)Nc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| CHEMBL4299294 | 220340 | 0 | None | -3 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@H](C)O)C(C)C)C(=O)N[C@H](C)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](C)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@H](C)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H]1CCC(=O)NCCCC[C@H](C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)NC(CC2CCCCC2)C(=O)N[C@H](CC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C(N)=O)[C@H](C)CC)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](C)NC1=O | 10.1021/acs.jmedchem.5b00926 | |||||
| CHEMBL4299355 | 220353 | 0 | None | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(=O)O)NC(C)=O)[C@H](C)O)C(C)C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||||
| 44392722 | 71340 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 439 | 7 | 0 | 5 | 6.1 | CCCCN(CCC)c1cc(C)nc2c(-c3ncc(C(F)(F)F)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL181536 | 71340 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 439 | 7 | 0 | 5 | 6.1 | CCCCN(CCC)c1cc(C)nc2c(-c3ncc(C(F)(F)F)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 44392695 | 130650 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 425 | 6 | 0 | 5 | 5.7 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(C(F)(F)F)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL362697 | 130650 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 425 | 6 | 0 | 5 | 5.7 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(C(F)(F)F)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 44341892 | 117097 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 418 | 8 | 0 | 4 | 6.7 | CCCCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL323886 | 117097 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 418 | 8 | 0 | 4 | 6.7 | CCCCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 10668220 | 38052 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 391 | 6 | 1 | 5 | 5.7 | CCCC(CC)Nc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| CHEMBL140143 | 38052 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 391 | 6 | 1 | 5 | 5.7 | CCCC(CC)Nc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| 10832574 | 123567 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 363 | 4 | 0 | 5 | 4.6 | CCN(CC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| CHEMBL337768 | 123567 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 363 | 4 | 0 | 5 | 4.6 | CCN(CC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| 44347200 | 168520 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 382 | 8 | 0 | 6 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(OC)c(OC)c3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL413756 | 168520 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 382 | 8 | 0 | 6 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(OC)c(OC)c3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 11774042 | 210131 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL65078 | 210131 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 44341936 | 16388 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 404 | 7 | 0 | 4 | 6.3 | CCCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL112626 | 16388 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 404 | 7 | 0 | 4 | 6.3 | CCCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 44341723 | 174912 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 416 | 7 | 0 | 4 | 6.3 | CCCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL432976 | 174912 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 416 | 7 | 0 | 4 | 6.3 | CCCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 18629227 | 108264 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 389 | 4 | 0 | 5 | 5.5 | CCC(CC)n1nnc2c(N3CCc4cc(Cl)cc(Cl)c43)nc(C)cc21 | 10.1021/jm990590f | |||
| CHEMBL297868 | 108264 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 389 | 4 | 0 | 5 | 5.5 | CCC(CC)n1nnc2c(N3CCc4cc(Cl)cc(Cl)c43)nc(C)cc21 | 10.1021/jm990590f | |||
| 90231873 | 130728 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 494 | 6 | 1 | 4 | 5.6 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Br)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628728 | 130728 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 494 | 6 | 1 | 4 | 5.6 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Br)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| 23595046 | 70784 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 383 | 7 | 1 | 5 | 5.1 | CCC(CC)Nc1nc(C)c(-c2ccc(C(F)(F)F)cc2OC)nc1OC | 10.1021/jm200365y | |||
| CHEMBL1807054 | 70784 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 383 | 7 | 1 | 5 | 5.1 | CCC(CC)Nc1nc(C)c(-c2ccc(C(F)(F)F)cc2OC)nc1OC | 10.1021/jm200365y | |||
| 11236249 | 132977 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 448 | 6 | 0 | 6 | 5.5 | CCN(Cc1ccc(Cl)cc1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL364987 | 132977 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 448 | 6 | 0 | 6 | 5.5 | CCN(Cc1ccc(Cl)cc1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 10648981 | 127520 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 497 | 7 | 0 | 5 | 6.7 | CCCCN(CC)c1nc(C)nc2c1nc(C(F)(F)F)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL354982 | 127520 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 497 | 7 | 0 | 5 | 6.7 | CCCCN(CC)c1nc(C)nc2c1nc(C(F)(F)F)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44341845 | 16270 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 436 | 8 | 0 | 5 | 6.2 | CCCCN(CCSC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL112057 | 16270 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 436 | 8 | 0 | 5 | 6.2 | CCCCN(CCSC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 22248935 | 70782 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 399 | 9 | 1 | 5 | 5.6 | CCc1nc(NC(CC)CC)c(OC)nc1-c1ccc(OC(F)F)cc1Cl | 10.1021/jm200365y | |||
| CHEMBL1807052 | 70782 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 399 | 9 | 1 | 5 | 5.6 | CCc1nc(NC(CC)CC)c(OC)nc1-c1ccc(OC(F)F)cc1Cl | 10.1021/jm200365y | |||
| 10479355 | 136257 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 459 | 8 | 0 | 6 | 5.6 | CCCCN(CC)c1nc(C)nc2c1nc(OC)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL367253 | 136257 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 459 | 8 | 0 | 6 | 5.6 | CCCCN(CC)c1nc(C)nc2c1nc(OC)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 44386320 | 138122 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 463 | 7 | 0 | 5 | 6.3 | CCCCN(CC)c1nc(C)nc2c1nc(Cl)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL368772 | 138122 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 463 | 7 | 0 | 5 | 6.3 | CCCCN(CC)c1nc(C)nc2c1nc(Cl)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 10813254 | 127539 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 445 | 8 | 0 | 6 | 5.8 | CCCCC(CC)Oc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL355214 | 127539 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 445 | 8 | 0 | 6 | 5.8 | CCCCC(CC)Oc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44341735 | 117698 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 430 | 8 | 0 | 4 | 6.7 | CCCCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL326156 | 117698 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 430 | 8 | 0 | 4 | 6.7 | CCCCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 15486940 | 166580 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 356 | 5 | 1 | 4 | 5.6 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(C)cc3Cl)c(C)nn12 | 10.1016/j.ejmech.2016.11.019 | |||
| CHEMBL4105538 | 166580 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 356 | 5 | 1 | 4 | 5.6 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(C)cc3Cl)c(C)nn12 | 10.1016/j.ejmech.2016.11.019 | |||
| 9952997 | 177382 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1021/jm049085v | |||
| CHEMBL445075 | 177382 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1021/jm049085v | |||
| 11462455 | 121550 | 2 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 356 | 6 | 0 | 4 | 5.3 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL333903 | 121550 | 2 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 356 | 6 | 0 | 4 | 5.3 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 3495 | 7958 | 28 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm9904351 | |||
| 5311055 | 7958 | 28 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm9904351 | |||
| CHEMBL9946 | 7958 | 28 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm9904351 | |||
| 10136000 | 35912 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 405 | 7 | 1 | 5 | 6.1 | CCCC(CCC)Nc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| CHEMBL138154 | 35912 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 405 | 7 | 1 | 5 | 6.1 | CCCC(CCC)Nc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| 10692703 | 39147 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 405 | 7 | 1 | 5 | 6.1 | CCCCC(CC)Nc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| CHEMBL141085 | 39147 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 405 | 7 | 1 | 5 | 6.1 | CCCCC(CC)Nc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| 11774042 | 210131 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL65078 | 210131 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm040058e | |||
| 3495 | 7958 | 28 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm980224g | |||
| 5311055 | 7958 | 28 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm980224g | |||
| CHEMBL9946 | 7958 | 28 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm980224g | |||
| 44392653 | 130009 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 473 | 6 | 0 | 5 | 6.5 | CCCN(Cc1ccccc1)c1cc(C)nc2c(-c3ncc(C(F)(F)F)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL361314 | 130009 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 473 | 6 | 0 | 5 | 6.5 | CCCN(Cc1ccccc1)c1cc(C)nc2c(-c3ncc(C(F)(F)F)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 9951076 | 74185 | 2 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 366 | 7 | 0 | 6 | 4.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(N(C)C)nc3)c(C)nn12 | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL188844 | 74185 | 2 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 366 | 7 | 0 | 6 | 4.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(N(C)C)nc3)c(C)nn12 | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL2165204 | 74185 | 2 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 366 | 7 | 0 | 6 | 4.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(N(C)C)nc3)c(C)nn12 | 10.1016/j.bmcl.2012.08.112 | |||
| 10291750 | 91388 | 26 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 355 | 7 | 1 | 7 | 3.8 | CCC(COC)n1nnc2c(Nc3ccc(OC)cc3C)nc(C)cc21 | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL2165203 | 91388 | 26 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 355 | 7 | 1 | 7 | 3.8 | CCC(COC)n1nnc2c(Nc3ccc(OC)cc3C)nc(C)cc21 | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL2221285 | 91388 | 26 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 355 | 7 | 1 | 7 | 3.8 | CCC(COC)n1nnc2c(Nc3ccc(OC)cc3C)nc(C)cc21 | 10.1016/j.bmcl.2012.08.112 | |||
| 78075688 | 91389 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 436 | 9 | 0 | 6 | 4.4 | COCCN(CCOC)Cc1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL2165205 | 91389 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 436 | 9 | 0 | 6 | 4.4 | COCCN(CCOC)Cc1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL2221286 | 91389 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 436 | 9 | 0 | 6 | 4.4 | COCCN(CCOC)Cc1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2012.08.112 | |||
| 3499 | 8230 | 28 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1016/j.ejmech.2021.113537 | |||
| 9909468 | 8230 | 28 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1016/j.ejmech.2021.113537 | |||
| CHEMBL44698 | 8230 | 28 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1016/j.ejmech.2021.113537 | |||
| 9931767 | 16288 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 416 | 7 | 0 | 4 | 6.4 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(CC)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL112152 | 16288 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 416 | 7 | 0 | 4 | 6.4 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(CC)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| 9952997 | 177382 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL445075 | 177382 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| 9952997 | 177382 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL445075 | 177382 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 3499 | 8230 | 28 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm990590f | |||
| 9909468 | 8230 | 28 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm990590f | |||
| CHEMBL44698 | 8230 | 28 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm990590f | |||
| 137645497 | 164413 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 356 | 5 | 1 | 4 | 5.6 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(Cl)cc3C)c(C)nn12 | 10.1016/j.ejmech.2016.11.019 | |||
| CHEMBL4081285 | 164413 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 356 | 5 | 1 | 4 | 5.6 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(Cl)cc3C)c(C)nn12 | 10.1016/j.ejmech.2016.11.019 | |||
| 3499 | 8230 | 28 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm9904351 | |||
| 9909468 | 8230 | 28 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm9904351 | |||
| CHEMBL44698 | 8230 | 28 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm9904351 | |||
| 176157 | 9515 | 28 | None | 9 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1021/jm960149e | |||
| 3512 | 9515 | 28 | None | 9 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1021/jm960149e | |||
| CHEMBL45281 | 9515 | 28 | None | 9 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1021/jm960149e | |||
| 176157 | 9515 | 28 | None | 9 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1021/jm9900117 | |||
| 3512 | 9515 | 28 | None | 9 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1021/jm9900117 | |||
| CHEMBL45281 | 9515 | 28 | None | 9 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1021/jm9900117 | |||
| 3499 | 8230 | 28 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm990590f | |||
| 9909468 | 8230 | 28 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm990590f | |||
| CHEMBL44698 | 8230 | 28 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10.1021/jm990590f | |||
| 10224173 | 39145 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| CHEMBL141084 | 39145 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.8 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| 10344587 | 174623 | 0 | None | 1 | 2 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 467 | 8 | 0 | 7 | 3.9 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(Br)cc3Cl)c(C)nn12 | 10.1021/jm034077k | |||
| CHEMBL1762817 | 174623 | 0 | None | 1 | 2 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 467 | 8 | 0 | 7 | 3.9 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(Br)cc3Cl)c(C)nn12 | 10.1021/jm034077k | |||
| CHEMBL430892 | 174623 | 0 | None | 1 | 2 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 467 | 8 | 0 | 7 | 3.9 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(Br)cc3Cl)c(C)nn12 | 10.1021/jm034077k | |||
| 9824227 | 65725 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 433 | 7 | 0 | 7 | 4.2 | CCC(COC)Oc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL168936 | 65725 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 433 | 7 | 0 | 7 | 4.2 | CCC(COC)Oc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 9931814 | 65792 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 417 | 6 | 0 | 6 | 5.0 | CCC(CC)Oc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169248 | 65792 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 417 | 6 | 0 | 6 | 5.0 | CCC(CC)Oc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44347138 | 22043 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 382 | 8 | 0 | 6 | 4.7 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL121286 | 22043 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 382 | 8 | 0 | 6 | 4.7 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 23595043 | 70779 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 357 | 9 | 1 | 5 | 4.9 | CCc1cc(OC)ccc1-c1nc(OC)c(NC(CC)CC)nc1CC | 10.1021/jm200365y | |||
| CHEMBL1807049 | 70779 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 357 | 9 | 1 | 5 | 4.9 | CCc1cc(OC)ccc1-c1nc(OC)c(NC(CC)CC)nc1CC | 10.1021/jm200365y | |||
| 10786785 | 35913 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 393 | 6 | 1 | 6 | 4.6 | CCC(COC)Nc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| CHEMBL138155 | 35913 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 393 | 6 | 1 | 6 | 4.6 | CCC(COC)Nc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| 11639435 | 78346 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 376 | 5 | 0 | 5 | 4.7 | CC[C@H]1Cn2nc(-c3ccc(OC)cc3C)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL196312 | 78346 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 376 | 5 | 0 | 5 | 4.7 | CC[C@H]1Cn2nc(-c3ccc(OC)cc3C)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 11575986 | 131146 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 448 | 4 | 0 | 4 | 6.7 | Cc1cc2c3c(n1)c(-c1ccc(Cl)cc1Cl)nn3C[C@H](c1ccccc1)N2CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL363779 | 131146 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 448 | 4 | 0 | 4 | 6.7 | Cc1cc2c3c(n1)c(-c1ccc(Cl)cc1Cl)nn3C[C@H](c1ccccc1)N2CC1CC1 | 10.1021/jm049085v | |||
| 10740981 | 64610 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 4.0 | CCN(CC)c1nc(C)nc(N(CC)c2c(Br)cc(OC)cc2OC)n1 | 10.1021/jm980222w | |||
| CHEMBL167122 | 64610 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 4.0 | CCN(CC)c1nc(C)nc(N(CC)c2c(Br)cc(OC)cc2OC)n1 | 10.1021/jm980222w | |||
| 10595854 | 127037 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 378 | 8 | 0 | 6 | 4.5 | CCN(CC)c1cc(C)nc(N(CC)c2c(Cl)cc(OC)cc2OC)n1 | 10.1021/jm980222w | |||
| CHEMBL352378 | 127037 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 378 | 8 | 0 | 6 | 4.5 | CCN(CC)c1cc(C)nc(N(CC)c2c(Cl)cc(OC)cc2OC)n1 | 10.1021/jm980222w | |||
| 44392741 | 72014 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 367 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(OC)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL182700 | 72014 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 367 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(OC)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 11164902 | 73076 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N(C)C)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL184850 | 73076 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N(C)C)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 44375351 | 63292 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 424 | 9 | 0 | 4 | 6.6 | CCCCN(CCCCF)c1nc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(00)00071-8 | |||
| CHEMBL163618 | 63292 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 424 | 9 | 0 | 4 | 6.6 | CCCCN(CCCCF)c1nc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(00)00071-8 | |||
| 44307737 | 107629 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 383 | 8 | 0 | 7 | 4.0 | CCCN(CCC)c1nc(C)nc2c(-c3ccc(OC)cc3OC)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL293469 | 107629 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 383 | 8 | 0 | 7 | 4.0 | CCCN(CCC)c1nc(C)nc2c(-c3ccc(OC)cc3OC)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 11164902 | 73076 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL184850 | 73076 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 44337527 | 14220 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 402 | 7 | 0 | 4 | 5.0 | CCCN(c1nc(-c2ccc(Br)cc2C)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL108673 | 14220 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 402 | 7 | 0 | 4 | 5.0 | CCCN(c1nc(-c2ccc(Br)cc2C)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| 44266482 | 11271 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 477 | 5 | 0 | 3 | 7.8 | CCN(c1nc(C)cc(-c2c(Cl)cccc2Cl)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL10208 | 11271 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 477 | 5 | 0 | 3 | 7.8 | CCN(c1nc(C)cc(-c2c(Cl)cccc2Cl)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 10813394 | 65945 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 448 | 8 | 1 | 8 | 3.5 | COCC(COC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169998 | 65945 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 448 | 8 | 1 | 8 | 3.5 | COCC(COC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44341818 | 117272 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 420 | 8 | 0 | 5 | 5.5 | CCCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL324889 | 117272 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 420 | 8 | 0 | 5 | 5.5 | CCCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 9867507 | 65841 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 432 | 7 | 0 | 7 | 3.9 | CCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169539 | 65841 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 432 | 7 | 0 | 7 | 3.9 | CCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 10576086 | 65875 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 463 | 9 | 0 | 9 | 2.4 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(N(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169711 | 65875 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 463 | 9 | 0 | 9 | 2.4 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(N(C)C)cc1Br | 10.1021/jm980224g | |||
| 44341817 | 179354 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 420 | 7 | 0 | 5 | 5.4 | COCCN(CC(C)C)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL448788 | 179354 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 420 | 7 | 0 | 5 | 5.4 | COCCN(CC(C)C)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 10574875 | 127522 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 434 | 7 | 0 | 7 | 4.6 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1ccc(SC)cc1Br | 10.1021/jm980224g | |||
| CHEMBL355006 | 127522 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 434 | 7 | 0 | 7 | 4.6 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1ccc(SC)cc1Br | 10.1021/jm980224g | |||
| 12967651 | 26691 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 445 | 8 | 0 | 4 | 6.8 | CCCN(Cc1sc(N(C)c2c(C)cc(C)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL130264 | 26691 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 445 | 8 | 0 | 4 | 6.8 | CCCN(Cc1sc(N(C)c2c(C)cc(C)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 44392710 | 71374 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 366 | 7 | 0 | 7 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N=O)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL181684 | 71374 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 366 | 7 | 0 | 7 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N=O)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 10671924 | 66150 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 466 | 7 | 0 | 8 | 3.3 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1ccc(S(C)(=O)=O)cc1Br | 10.1021/jm980224g | |||
| CHEMBL170844 | 66150 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 466 | 7 | 0 | 8 | 3.3 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1ccc(S(C)(=O)=O)cc1Br | 10.1021/jm980224g | |||
| 44347108 | 22018 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 370 | 7 | 0 | 4 | 5.5 | CCCN(CCC)c1cc(CC)nc2c(-c3ccc(Cl)cc3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL121116 | 22018 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 370 | 7 | 0 | 4 | 5.5 | CCCN(CCC)c1cc(CC)nc2c(-c3ccc(Cl)cc3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 44305971 | 107380 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 395 | 10 | 0 | 6 | 4.4 | C=CCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL291828 | 107380 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 395 | 10 | 0 | 6 | 4.4 | C=CCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| 20780034 | 137246 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 382 | 7 | 0 | 4 | 4.8 | CCCN(CCC)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL368041 | 137246 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 382 | 7 | 0 | 4 | 4.8 | CCCN(CCC)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 10298157 | 130011 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 457 | 8 | 1 | 4 | 7.3 | C=CCN(CCC)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL361323 | 130011 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 457 | 8 | 1 | 4 | 7.3 | C=CCN(CCC)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 10207702 | 138769 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 508 | 8 | 1 | 5 | 7.7 | CCCN(Cc1ccncc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL369531 | 138769 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 508 | 8 | 1 | 5 | 7.7 | CCCN(Cc1ccncc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 11246476 | 130833 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 396 | 6 | 0 | 7 | 3.4 | CCCC(OC)N1CCn2c(=O)n(-c3ccc(OC)cc3C)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL363152 | 130833 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 396 | 6 | 0 | 7 | 3.4 | CCCC(OC)N1CCn2c(=O)n(-c3ccc(OC)cc3C)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 44389125 | 71391 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 429 | 4 | 1 | 4 | 6.5 | FC(F)(F)c1nc(Nc2c(Cl)cc(Cl)cc2Cl)sc1CN1CCCC1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181765 | 71391 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 429 | 4 | 1 | 4 | 6.5 | FC(F)(F)c1nc(Nc2c(Cl)cc(Cl)cc2Cl)sc1CN1CCCC1 | 10.1016/j.bmcl.2004.10.055 | |||
| 44460545 | 212346 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 6.8 | O=C(CCc1ccncc1)C(Nc1ccc(Cl)cc1Cl)c1ccccc1C(F)(F)F | 10.1021/jm049974i | |||
| CHEMBL81262 | 212346 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 6.8 | O=C(CCc1ccncc1)C(Nc1ccc(Cl)cc1Cl)c1ccccc1C(F)(F)F | 10.1021/jm049974i | |||
| 10790231 | 65812 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 462 | 10 | 0 | 10 | 2.1 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1S(C)(=O)=O | 10.1021/jm980224g | |||
| CHEMBL169365 | 65812 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 462 | 10 | 0 | 10 | 2.1 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1S(C)(=O)=O | 10.1021/jm980224g | |||
| 44446715 | 101516 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCN(CCC)c1c(C)nc(-c2ccc(Cl)cc2Cl)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL253084 | 101516 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCN(CCC)c1c(C)nc(-c2ccc(Cl)cc2Cl)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 44460553 | 212675 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 442 | 7 | 1 | 3 | 6.2 | Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2Br)c(Cl)c1 | 10.1021/jm049974i | |||
| CHEMBL83914 | 212675 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 442 | 7 | 1 | 3 | 6.2 | Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2Br)c(Cl)c1 | 10.1021/jm049974i | |||
| 10548395 | 109637 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 389 | 8 | 1 | 5 | 5.7 | CCCCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960148m | |||
| CHEMBL305671 | 109637 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 389 | 8 | 1 | 5 | 5.7 | CCCCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960148m | |||
| 10542924 | 211917 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 309 | 3 | 1 | 5 | 3.6 | Cc1cc(C)c(Nc2nc(C)nc(N3CC=CCC3)n2)c(C)c1 | 10.1021/jm960148m | |||
| CHEMBL78035 | 211917 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 309 | 3 | 1 | 5 | 3.6 | Cc1cc(C)c(Nc2nc(C)nc(N3CC=CCC3)n2)c(C)c1 | 10.1021/jm960148m | |||
| 10548395 | 109637 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 389 | 8 | 1 | 5 | 5.7 | CCCCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm9900117 | |||
| CHEMBL305671 | 109637 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 389 | 8 | 1 | 5 | 5.7 | CCCCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm9900117 | |||
| 10542924 | 211917 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 309 | 3 | 1 | 5 | 3.6 | Cc1cc(C)c(Nc2nc(C)nc(N3CC=CCC3)n2)c(C)c1 | 10.1021/jm9900117 | |||
| CHEMBL78035 | 211917 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 309 | 3 | 1 | 5 | 3.6 | Cc1cc(C)c(Nc2nc(C)nc(N3CC=CCC3)n2)c(C)c1 | 10.1021/jm9900117 | |||
| 44446735 | 101404 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCCN(CCn1ccnc1)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL252301 | 101404 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 428 | 8 | 0 | 5 | 5.9 | CCCN(CCn1ccnc1)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 44460602 | 212525 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 459 | 6 | 2 | 4 | 6.2 | COc1ccc(C(=O)C(Nc2ccc(C)cc2Cl)c2ccccc2Br)cc1O | 10.1021/jm049974i | |||
| CHEMBL82707 | 212525 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 459 | 6 | 2 | 4 | 6.2 | COc1ccc(C(=O)C(Nc2ccc(C)cc2Cl)c2ccccc2Br)cc1O | 10.1021/jm049974i | |||
| 44317955 | 110697 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 470 | 6 | 2 | 3 | 5.8 | CNC(=O)c1cccc(C(=O)C(Nc2ccc(C)cc2Cl)c2ccccc2Br)c1 | 10.1021/jm049974i | |||
| CHEMBL309244 | 110697 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 470 | 6 | 2 | 3 | 5.8 | CNC(=O)c1cccc(C(=O)C(Nc2ccc(C)cc2Cl)c2ccccc2Br)c1 | 10.1021/jm049974i | |||
| 11395370 | 80953 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 396 | 5 | 2 | 5 | 4.4 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(CO)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL202299 | 80953 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 396 | 5 | 2 | 5 | 4.4 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(CO)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| 11065773 | 209774 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 278 | 4 | 2 | 4 | 2.8 | CC(=O)/C(=N\c1ccccc1)NNc1ccccc1C#N | 10.1021/jm025512y | |||
| CHEMBL63140 | 209774 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 278 | 4 | 2 | 4 | 2.8 | CC(=O)/C(=N\c1ccccc1)NNc1ccccc1C#N | 10.1021/jm025512y | |||
| 44266473 | 11190 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 409 | 5 | 0 | 3 | 6.5 | CCN(c1nc(C)cc(-c2ccccc2)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL10150 | 11190 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 409 | 5 | 0 | 3 | 6.5 | CCN(c1nc(C)cc(-c2ccccc2)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 10494830 | 127126 | 1 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 305 | 2 | 0 | 3 | 3.9 | Cc1ccc(N(C)c2nc(C)cc(C)n2)c(Br)c1 | 10.1021/jm980222w | |||
| CHEMBL353075 | 127126 | 1 | None | - | 1 | Rat | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 305 | 2 | 0 | 3 | 3.9 | Cc1ccc(N(C)c2nc(C)cc(C)n2)c(Br)c1 | 10.1021/jm980222w | |||
| 20780064 | 131107 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 480 | 7 | 0 | 4 | 6.8 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CC4CC4)CC4CC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL363592 | 131107 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 480 | 7 | 0 | 4 | 6.8 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CC4CC4)CC4CC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| 11797750 | 64870 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 448 | 10 | 0 | 5 | 5.7 | CCCN(CCOC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL167444 | 64870 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 448 | 10 | 0 | 5 | 5.7 | CCCN(CCOC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 10739468 | 65779 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 395 | 7 | 0 | 5 | 4.9 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(N(C)C)cc2C(F)(F)F)n1 | 10.1021/jm980222w | |||
| CHEMBL169094 | 65779 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 395 | 7 | 0 | 5 | 4.9 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(N(C)C)cc2C(F)(F)F)n1 | 10.1021/jm980222w | |||
| 44347356 | 119646 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 372 | 7 | 1 | 5 | 4.5 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3)c(CO)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL330954 | 119646 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 372 | 7 | 1 | 5 | 4.5 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3)c(CO)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 44341712 | 121738 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL334262 | 121738 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 10024020 | 209881 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 401 | 9 | 0 | 5 | 5.2 | CCCN(c1nccc(-c2c(Cl)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL63989 | 209881 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 401 | 9 | 0 | 5 | 5.2 | CCCN(c1nccc(-c2c(Cl)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| 44307806 | 210551 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 393 | 8 | 0 | 5 | 5.8 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(C)cc3C)n(CCC)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL68076 | 210551 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 393 | 8 | 0 | 5 | 5.8 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(C)cc3C)n(CCC)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 44305523 | 108945 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 6 | 0 | 5 | 4.8 | CCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| CHEMBL302645 | 108945 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 392 | 6 | 0 | 5 | 4.8 | CCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| 20780164 | 100496 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 421 | 7 | 0 | 5 | 5.7 | C=CCN(CCC)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL247151 | 100496 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 421 | 7 | 0 | 5 | 5.7 | C=CCN(CCC)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 20780148 | 157902 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 435 | 7 | 0 | 5 | 5.9 | CCCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12)CC1CC1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL395929 | 157902 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 435 | 7 | 0 | 5 | 5.9 | CCCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12)CC1CC1 | 10.1016/j.bmcl.2007.01.008 | |||
| 9980466 | 160907 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 436 | 9 | 1 | 6 | 5.2 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OCCF | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL398531 | 160907 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 436 | 9 | 1 | 6 | 5.2 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OCCF | 10.1016/j.bmcl.2007.09.008 | |||
| 10302495 | 130067 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 541 | 8 | 1 | 4 | 8.9 | CCCN(Cc1ccc(Cl)cc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL361438 | 130067 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 541 | 8 | 1 | 4 | 8.9 | CCCN(Cc1ccc(Cl)cc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 11189570 | 134261 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 428 | 6 | 0 | 6 | 5.2 | Cc1cc(N(Cc2ccccc2)C(C)C)n2nc(C)c(-c3cnc(N(C)C)cc3C)c2n1 | 10.1021/jm040058e | |||
| CHEMBL366096 | 134261 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 428 | 6 | 0 | 6 | 5.2 | Cc1cc(N(Cc2ccccc2)C(C)C)n2nc(C)c(-c3cnc(N(C)C)cc3C)c2n1 | 10.1021/jm040058e | |||
| 9803645 | 65497 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 446 | 7 | 0 | 7 | 4.3 | CCC(COC)N(C)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL168519 | 65497 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 446 | 7 | 0 | 7 | 4.3 | CCC(COC)N(C)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44341858 | 117911 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 446 | 7 | 0 | 5 | 6.0 | CCCCN(CC1CCCO1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL326355 | 117911 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 446 | 7 | 0 | 5 | 6.0 | CCCCN(CC1CCCO1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 18691306 | 105352 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 451 | 5 | 0 | 3 | 7.4 | CCN(c1nc(C)cc(-c2c(C)cc(C)cc2C)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL276716 | 105352 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 451 | 5 | 0 | 3 | 7.4 | CCN(c1nc(C)cc(-c2c(C)cc(C)cc2C)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 22249041 | 70751 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 358 | 9 | 1 | 6 | 4.3 | CCc1nc(-c2ccc(OC)nc2OC)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1806958 | 70751 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 358 | 9 | 1 | 6 | 4.3 | CCc1nc(-c2ccc(OC)nc2OC)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 11155051 | 113127 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 446 | 8 | 0 | 5 | 6.2 | CCCN(c1nc(-c2ccc(OC)cc2C)n(C)n1)[C@@H](CC)c1ccc(C(F)(F)F)cc1 | 10.1021/jm049339c | |||
| CHEMBL3085415 | 113127 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 446 | 8 | 0 | 5 | 6.2 | CCCN(c1nc(-c2ccc(OC)cc2C)n(C)n1)[C@@H](CC)c1ccc(C(F)(F)F)cc1 | 10.1021/jm049339c | |||
| CHEMBL3139200 | 113127 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 446 | 8 | 0 | 5 | 6.2 | CCCN(c1nc(-c2ccc(OC)cc2C)n(C)n1)[C@@H](CC)c1ccc(C(F)(F)F)cc1 | 10.1021/jm049339c | |||
| 136216703 | 85680 | 0 | None | -5 | 5 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 482 | 2 | 4 | 7 | 4.0 | N[C@H]1CCCC[C@@H]1NC(=O)c1c2c(c3c4c(ncnc14)-c1ccccc1C3=O)N[C@@H]1CCCC[C@H]1N2 | 10.1016/s0960-894x(99)00075-x | |||
| CHEMBL2112936 | 85680 | 0 | None | -5 | 5 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 482 | 2 | 4 | 7 | 4.0 | N[C@H]1CCCC[C@@H]1NC(=O)c1c2c(c3c4c(ncnc14)-c1ccccc1C3=O)N[C@@H]1CCCC[C@H]1N2 | 10.1016/s0960-894x(99)00075-x | |||
| 44392740 | 130604 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 337 | 6 | 0 | 5 | 4.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncccc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL362437 | 130604 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 337 | 6 | 0 | 5 | 4.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncccc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 10142769 | 13274 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 520 | 8 | 0 | 4 | 7.3 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCC4CC4)CCC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1082720 | 13274 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 520 | 8 | 0 | 4 | 7.3 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCC4CC4)CCC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 44392771 | 73445 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 399 | 10 | 0 | 7 | 3.7 | CCCN(CC1CC1)c1cc(C(=O)c2c(OC)cc(OC)cc2OC)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL185400 | 73445 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 399 | 10 | 0 | 7 | 3.7 | CCCN(CC1CC1)c1cc(C(=O)c2c(OC)cc(OC)cc2OC)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| 44389050 | 69276 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 505 | 6 | 2 | 8 | 7.1 | CSc1snnc1NCc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL178131 | 69276 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 505 | 6 | 2 | 8 | 7.1 | CSc1snnc1NCc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 10140223 | 130033 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 471 | 8 | 1 | 4 | 7.5 | CCN(CCC1CC1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL361394 | 130033 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 471 | 8 | 1 | 4 | 7.5 | CCN(CCC1CC1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 10160871 | 26584 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 445 | 8 | 1 | 4 | 6.7 | CCCN(CC1CC1)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1CC | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL130180 | 26584 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 445 | 8 | 1 | 4 | 6.7 | CCCN(CC1CC1)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1CC | 10.1016/j.bmcl.2003.08.055 | |||
| 10551027 | 64363 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 438 | 3 | 0 | 5 | 4.9 | Cc1cc(N2CCOCC2)c2c(C#N)cn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| CHEMBL166760 | 64363 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 438 | 3 | 0 | 5 | 4.9 | Cc1cc(N2CCOCC2)c2c(C#N)cn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| 44307652 | 210577 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 391 | 7 | 1 | 5 | 5.6 | CCCCCCNc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL68303 | 210577 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 391 | 7 | 1 | 5 | 5.6 | CCCCCCNc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 44385525 | 66814 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 394 | 6 | 0 | 7 | 3.4 | CCCN(CC1CC1)c1nc(C)nc2c1n(C)c(=O)n2-c1c(C)cc(C)nc1C | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL173624 | 66814 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 394 | 6 | 0 | 7 | 3.4 | CCCN(CC1CC1)c1nc(C)nc2c1n(C)c(=O)n2-c1c(C)cc(C)nc1C | 10.1016/s0960-894x(99)00108-0 | |||
| 10902707 | 210377 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 301 | 4 | 2 | 3 | 3.9 | CC(=O)/C(=N\c1cccc(C)c1)NNc1ccccc1Cl | 10.1021/jm025512y | |||
| CHEMBL66950 | 210377 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 301 | 4 | 2 | 3 | 3.9 | CC(=O)/C(=N\c1cccc(C)c1)NNc1ccccc1Cl | 10.1021/jm025512y | |||
| 44308155 | 210494 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 446 | 7 | 0 | 6 | 5.0 | CCCN(CCN1CCCC1)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL67646 | 210494 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 446 | 7 | 0 | 6 | 5.0 | CCCN(CCN1CCCC1)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 44443574 | 101106 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 381 | 8 | 2 | 5 | 5.6 | CCc1nc(NC(CC)CC)c(CC)nc1Nc1ncc(Cl)cc1Cl | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL250616 | 101106 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 381 | 8 | 2 | 5 | 5.6 | CCc1nc(NC(CC)CC)c(CC)nc1Nc1ncc(Cl)cc1Cl | 10.1016/j.bmcl.2007.09.008 | |||
| 10567951 | 211857 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 323 | 7 | 1 | 5 | 4.0 | C=CCN(CC=C)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960148m | |||
| CHEMBL77391 | 211857 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 323 | 7 | 1 | 5 | 4.0 | C=CCN(CC=C)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960148m | |||
| 10567951 | 211857 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 323 | 7 | 1 | 5 | 4.0 | C=CCN(CC=C)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm9900117 | |||
| CHEMBL77391 | 211857 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 323 | 7 | 1 | 5 | 4.0 | C=CCN(CC=C)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm9900117 | |||
| 10222698 | 194629 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 401 | 10 | 1 | 6 | 4.3 | CCCN(CCC)c1c(CC(C)O)nc(-c2c(C)cc(C)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL496269 | 194629 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 401 | 10 | 1 | 6 | 4.3 | CCCN(CCC)c1c(CC(C)O)nc(-c2c(C)cc(C)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| 44385545 | 67051 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 499 | 9 | 0 | 6 | 5.8 | CCCCN(CC)c1nc(C)nc2c1n(CC1CC1)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL174213 | 67051 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 499 | 9 | 0 | 6 | 5.8 | CCCCN(CC)c1nc(C)nc2c1n(CC1CC1)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 44385463 | 68153 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 433 | 6 | 1 | 7 | 3.4 | COCCNc1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL176937 | 68153 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 433 | 6 | 1 | 7 | 3.4 | COCCNc1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 20780127 | 142020 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 446 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)C(=O)c1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ccc(F)cc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL372499 | 142020 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 446 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)C(=O)c1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ccc(F)cc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 135593026 | 70721 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 343 | 8 | 2 | 5 | 4.6 | CCc1nc(-c2ccc(OC)cc2O)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1806735 | 70721 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 343 | 8 | 2 | 5 | 4.6 | CCc1nc(-c2ccc(OC)cc2O)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 44443571 | 101105 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 314 | 7 | 0 | 5 | 4.2 | CCCN(CCC)c1nc(C)c(Oc2cc(C)ccn2)nc1C | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL250615 | 101105 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 314 | 7 | 0 | 5 | 4.2 | CCCN(CCC)c1nc(C)c(Oc2cc(C)ccn2)nc1C | 10.1016/j.bmcl.2007.09.008 | |||
| 11475729 | 82151 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 422 | 7 | 1 | 5 | 5.5 | C=CCOc1ccc(S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL203807 | 82151 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 422 | 7 | 1 | 5 | 5.5 | C=CCOc1ccc(S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2005.10.097 | |||
| 9887145 | 133429 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 398 | 6 | 0 | 5 | 4.9 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(Cl)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL365260 | 133429 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 398 | 6 | 0 | 5 | 4.9 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(Cl)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 9907170 | 184878 | 0 | None | -2 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 365 | 5 | 0 | 5 | 4.0 | CCN(c1nc(C)cc(C)n1)c1c(Br)cc(OC)cc1OC | 10.1021/jm980222w | |||
| CHEMBL46479 | 184878 | 0 | None | -2 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 365 | 5 | 0 | 5 | 4.0 | CCN(c1nc(C)cc(C)n1)c1c(Br)cc(OC)cc1OC | 10.1021/jm980222w | |||
| 44392687 | 73442 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 457 | 8 | 0 | 7 | 4.2 | COCCN(CCOC)c1cc(C)nc2c(-c3ncc(C(F)(F)F)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL185393 | 73442 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 457 | 8 | 0 | 7 | 4.2 | COCCN(CCOC)c1cc(C)nc2c(-c3ncc(C(F)(F)F)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 21916254 | 13177 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 576 | 7 | 0 | 4 | 8.3 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCC(F)(F)F)Cc4ccc(Cl)cc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1082338 | 13177 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 576 | 7 | 0 | 4 | 8.3 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCC(F)(F)F)Cc4ccc(Cl)cc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 10300313 | 13591 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 494 | 7 | 0 | 4 | 6.9 | CCCN(CCC(F)(F)F)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083935 | 13591 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 494 | 7 | 0 | 4 | 6.9 | CCCN(CCC(F)(F)F)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 22248932 | 70768 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 6.2 | CCc1nc(NC(CC)CC)c(I)nc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| CHEMBL1807034 | 70768 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 6.2 | CCc1nc(NC(CC)CC)c(I)nc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| 44388407 | 69785 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 466 | 8 | 0 | 5 | 6.5 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)C(CC)c1ccc(C(F)(F)F)cc1 | 10.1021/jm049339c | |||
| CHEMBL178735 | 69785 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 466 | 8 | 0 | 5 | 6.5 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)C(CC)c1ccc(C(F)(F)F)cc1 | 10.1021/jm049339c | |||
| 9907170 | 184878 | 0 | None | -2 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 365 | 5 | 0 | 5 | 4.0 | CCN(c1nc(C)cc(C)n1)c1c(Br)cc(OC)cc1OC | 10.1021/jm990590f | |||
| CHEMBL46479 | 184878 | 0 | None | -2 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 365 | 5 | 0 | 5 | 4.0 | CCN(c1nc(C)cc(C)n1)c1c(Br)cc(OC)cc1OC | 10.1021/jm990590f | |||
| 44341663 | 117651 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 432 | 8 | 0 | 4 | 5.9 | COCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)ccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL326107 | 117651 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 432 | 8 | 0 | 4 | 5.9 | COCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)ccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 44384779 | 66485 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 487 | 8 | 0 | 7 | 4.2 | COCCN(CC1CC1)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL172358 | 66485 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 487 | 8 | 0 | 7 | 4.2 | COCCN(CC1CC1)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 10739849 | 65277 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 401 | 5 | 0 | 5 | 4.9 | CCN(CC)c1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL168353 | 65277 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 401 | 5 | 0 | 5 | 4.9 | CCN(CC)c1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44341762 | 16927 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 406 | 7 | 0 | 5 | 5.1 | CCN(CCCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL115820 | 16927 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 406 | 7 | 0 | 5 | 5.1 | CCN(CCCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 11625175 | 78687 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 384 | 4 | 0 | 4 | 5.2 | CC[C@H]1Cn2nc(-c3ccc(F)cc3Cl)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL197187 | 78687 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 384 | 4 | 0 | 4 | 5.2 | CC[C@H]1Cn2nc(-c3ccc(F)cc3Cl)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 11530590 | 147554 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 360 | 4 | 0 | 4 | 5.0 | CC[C@H]1Cn2nc(-c3ccc(C)cc3C)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL381850 | 147554 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 360 | 4 | 0 | 4 | 5.0 | CC[C@H]1Cn2nc(-c3ccc(C)cc3C)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 9957261 | 72050 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 7 | 0 | 6 | 7.0 | CCCN(CC1CC1)c1nc(C)nc2c1sc(=S)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00159-6 | |||
| CHEMBL18285 | 72050 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 7 | 0 | 6 | 7.0 | CCCN(CC1CC1)c1nc(C)nc2c1sc(=S)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00159-6 | |||
| 10669526 | 172193 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 414 | 4 | 1 | 6 | 4.8 | Cc1nc(NC2CCCC2)c2nnn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980224g | |||
| CHEMBL423833 | 172193 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 414 | 4 | 1 | 6 | 4.8 | Cc1nc(NC2CCCC2)c2nnn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980224g | |||
| 44446738 | 101423 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 473 | 10 | 0 | 4 | 7.3 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OCCN2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL252492 | 101423 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 473 | 10 | 0 | 4 | 7.3 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OCCN2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 10117501 | 70959 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 493 | 7 | 1 | 4 | 7.9 | CCN(Cc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL180880 | 70959 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 493 | 7 | 1 | 4 | 7.9 | CCN(Cc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 11441193 | 70190 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 408 | 10 | 0 | 6 | 5.3 | CCCC(c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL179647 | 70190 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 408 | 10 | 0 | 6 | 5.3 | CCCC(c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 44337549 | 15946 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 352 | 7 | 0 | 4 | 4.8 | CCCN(c1nc(-c2c(C)cc(C)cc2C)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL110222 | 15946 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 352 | 7 | 0 | 4 | 4.8 | CCCN(c1nc(-c2c(C)cc(C)cc2C)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| 11223627 | 75446 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 410 | 6 | 0 | 6 | 3.9 | COCC(COC)N1CCc2cn(-c3ccc(Cl)cc3C#N)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL192082 | 75446 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 410 | 6 | 0 | 6 | 3.9 | COCC(COC)N1CCc2cn(-c3ccc(Cl)cc3C#N)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 44392731 | 130530 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 385 | 9 | 0 | 6 | 3.3 | COCCN(CCOC)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL362226 | 130530 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 385 | 9 | 0 | 6 | 3.3 | COCCN(CCOC)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 46891008 | 13206 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 424 | 3 | 0 | 4 | 5.7 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCCCC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1082441 | 13206 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 424 | 3 | 0 | 4 | 5.7 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCCCC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 20780056 | 153019 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 444 | 5 | 0 | 6 | 5.3 | Cc1cc(C)c(-n2c3ncccc3n3c(CN(C)Cc4ccncc4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL392044 | 153019 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 444 | 5 | 0 | 6 | 5.3 | Cc1cc(C)c(-n2c3ncccc3n3c(CN(C)Cc4ccncc4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| 20780286 | 14101 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 448 | 6 | 0 | 4 | 5.6 | CCCN(CC1CC1)C(=O)c1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1086164 | 14101 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 448 | 6 | 0 | 4 | 5.6 | CCCN(CC1CC1)C(=O)c1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| 44389097 | 69789 | 0 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 441 | 4 | 1 | 4 | 6.6 | FC(F)(F)c1nc(Nc2c(Cl)cc(Cl)cc2Cl)sc1CN1CC=CCC1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL178751 | 69789 | 0 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 441 | 4 | 1 | 4 | 6.6 | FC(F)(F)c1nc(Nc2c(Cl)cc(Cl)cc2Cl)sc1CN1CC=CCC1 | 10.1016/j.bmcl.2004.10.055 | |||
| 10853581 | 127042 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 326 | 5 | 1 | 7 | 2.5 | COCCNc1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL352436 | 127042 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 326 | 5 | 1 | 7 | 2.5 | COCCNc1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| 44443572 | 161553 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 326 | 7 | 0 | 5 | 4.2 | CCCN(CC1CC1)c1nc(C)c(Oc2cc(C)ccn2)nc1C | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL400155 | 161553 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 326 | 7 | 0 | 5 | 4.2 | CCCN(CC1CC1)c1nc(C)c(Oc2cc(C)ccn2)nc1C | 10.1016/j.bmcl.2007.09.008 | |||
| 44443661 | 100894 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 503 | 9 | 1 | 6 | 6.1 | CCc1nc(N(C)c2ncc(Cl)cc2Cl)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OCCF | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL249212 | 100894 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 503 | 9 | 1 | 6 | 6.1 | CCc1nc(N(C)c2ncc(Cl)cc2Cl)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OCCF | 10.1016/j.bmcl.2007.09.008 | |||
| 44443636 | 101189 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 390 | 6 | 1 | 6 | 4.7 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(C)c(Oc2cc(C)ccn2)nc1C | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL251006 | 101189 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 390 | 6 | 1 | 6 | 4.7 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(C)c(Oc2cc(C)ccn2)nc1C | 10.1016/j.bmcl.2007.09.008 | |||
| 9890659 | 105838 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 464 | 3 | 0 | 7 | 5.2 | Cc1nc(N2CCOCC2)c2sc(=S)n(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1016/s0960-894x(99)00159-6 | |||
| CHEMBL280449 | 105838 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 464 | 3 | 0 | 7 | 5.2 | Cc1nc(N2CCOCC2)c2sc(=S)n(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1016/s0960-894x(99)00159-6 | |||
| 10552595 | 65775 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 476 | 9 | 0 | 8 | 3.9 | CCN(c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br)C(COC)COC | 10.1021/jm980224g | |||
| CHEMBL169070 | 65775 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 476 | 9 | 0 | 8 | 3.9 | CCN(c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br)C(COC)COC | 10.1021/jm980224g | |||
| 44384893 | 66681 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 382 | 6 | 0 | 7 | 3.4 | CCCCN(CC)c1nc(C)nc2c1n(C)c(=O)n2-c1c(C)cc(C)nc1C | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL173074 | 66681 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 382 | 6 | 0 | 7 | 3.4 | CCCCN(CC)c1nc(C)nc2c1n(C)c(=O)n2-c1c(C)cc(C)nc1C | 10.1016/s0960-894x(99)00108-0 | |||
| 11684703 | 78512 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 400 | 4 | 0 | 4 | 5.7 | CC[C@@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL196604 | 78512 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 400 | 4 | 0 | 4 | 5.7 | CC[C@@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 20780017 | 71718 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 458 | 7 | 0 | 4 | 5.2 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1Br | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL182278 | 71718 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 458 | 7 | 0 | 4 | 5.2 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1Br | 10.1016/j.bmcl.2005.05.117 | |||
| 44443634 | 100760 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 418 | 7 | 0 | 6 | 4.8 | CCc1nc(N(C)[C@@H]2c3ccccc3C[C@@H]2OC)c(CC)nc1Oc1cc(C)ccn1 | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL248577 | 100760 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 418 | 7 | 0 | 6 | 4.8 | CCc1nc(N(C)[C@@H]2c3ccccc3C[C@@H]2OC)c(CC)nc1Oc1cc(C)ccn1 | 10.1016/j.bmcl.2007.09.008 | |||
| 10641825 | 127244 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 353 | 2 | 0 | 3 | 5.1 | Cc1ccc2c(C#N)cn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| CHEMBL354092 | 127244 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 353 | 2 | 0 | 3 | 5.1 | Cc1ccc2c(C#N)cn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| 53310410 | 70760 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 411 | 10 | 0 | 5 | 4.7 | CCc1nc(N(CCOC)CCOC)c(CC)nc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| CHEMBL1807026 | 70760 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 411 | 10 | 0 | 5 | 4.7 | CCc1nc(N(CCOC)CCOC)c(CC)nc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| 20780074 | 74445 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 522 | 7 | 0 | 4 | 7.4 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCC(F)(F)F)CC4CC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL190745 | 74445 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 522 | 7 | 0 | 4 | 7.4 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCC(F)(F)F)CC4CC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| 10643831 | 64388 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 385 | 10 | 0 | 6 | 4.5 | CCCCN(CCOC)c1nc(C)nc(N(CC)c2c(C)cc(C)cc2C)n1 | 10.1021/jm980222w | |||
| CHEMBL166835 | 64388 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 385 | 10 | 0 | 6 | 4.5 | CCCCN(CCOC)c1nc(C)nc(N(CC)c2c(C)cc(C)cc2C)n1 | 10.1021/jm980222w | |||
| 9866114 | 72024 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 407 | 10 | 0 | 4 | 5.6 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2c(CC)cc(CC)cc2CC)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL182752 | 72024 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 407 | 10 | 0 | 4 | 5.6 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2c(CC)cc(CC)cc2CC)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 44392693 | 73113 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 408 | 9 | 0 | 6 | 5.2 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N(CC)CC)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL185055 | 73113 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 408 | 9 | 0 | 6 | 5.2 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N(CC)CC)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 44392753 | 73429 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 366 | 7 | 1 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(C)cc3NC)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL185292 | 73429 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 366 | 7 | 1 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(C)cc3NC)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 44342015 | 116994 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 467 | 8 | 0 | 5 | 6.5 | CCCCN(CCc1ccccn1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL323756 | 116994 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 467 | 8 | 0 | 5 | 6.5 | CCCCN(CCc1ccccn1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 9846806 | 117388 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 6.4 | CCCN(Cc1ccc(O)cc1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL325638 | 117388 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 454 | 6 | 1 | 5 | 6.4 | CCCN(Cc1ccc(O)cc1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 46891116 | 13583 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 454 | 8 | 0 | 5 | 5.7 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3ccc(OC)cc3C)c(Cl)cn12)CC1CC1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083922 | 13583 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 454 | 8 | 0 | 5 | 5.7 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3ccc(OC)cc3C)c(Cl)cn12)CC1CC1 | 10.1016/j.bmcl.2010.04.094 | |||
| 20780266 | 13658 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 506 | 6 | 0 | 4 | 6.9 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CC4CCC4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1084235 | 13658 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 506 | 6 | 0 | 4 | 6.9 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CC4CCC4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 21916134 | 13899 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 436 | 7 | 0 | 4 | 5.9 | C=CCN(CC=C)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1085265 | 13899 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 436 | 7 | 0 | 4 | 5.9 | C=CCN(CC=C)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 21916107 | 14202 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 452 | 7 | 0 | 4 | 6.3 | CCN(CCC1CC1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1086594 | 14202 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 452 | 7 | 0 | 4 | 6.3 | CCN(CCC1CC1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 11280879 | 74321 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 394 | 7 | 1 | 6 | 5.0 | Cc1cc(NC(C)CCC(C)C)n2nc(C)c(-c3cnc(N(C)C)cc3C)c2n1 | 10.1021/jm040058e | |||
| CHEMBL189754 | 74321 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 394 | 7 | 1 | 6 | 5.0 | Cc1cc(NC(C)CCC(C)C)n2nc(C)c(-c3cnc(N(C)C)cc3C)c2n1 | 10.1021/jm040058e | |||
| 11306515 | 77227 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 459 | 7 | 0 | 5 | 5.7 | CCCC(CCC)N1CCc2cn(-c3ccc(S(C)(=O)=O)cc3Cl)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL194607 | 77227 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 459 | 7 | 0 | 5 | 5.7 | CCCC(CCC)N1CCc2cn(-c3ccc(S(C)(=O)=O)cc3Cl)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 11166658 | 140191 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 406 | 6 | 0 | 4 | 6.2 | CCCC(CCC)N1CCc2cn(-c3ccc(Cl)cc3C#N)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL370501 | 140191 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 406 | 6 | 0 | 4 | 6.2 | CCCC(CCC)N1CCc2cn(-c3ccc(Cl)cc3C#N)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 9844591 | 67587 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 412 | 6 | 0 | 6 | 6.1 | CCCN(CC1CC1)c1nc(C)nc2c1sc(=S)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00159-6 | |||
| CHEMBL17619 | 67587 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 412 | 6 | 0 | 6 | 6.1 | CCCN(CC1CC1)c1nc(C)nc2c1sc(=S)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00159-6 | |||
| 44266463 | 11334 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 443 | 5 | 0 | 3 | 7.1 | CCN(c1nc(C)cc(-c2ccccc2Cl)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL10249 | 11334 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 443 | 5 | 0 | 3 | 7.1 | CCN(c1nc(C)cc(-c2ccccc2Cl)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 44290640 | 108266 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 398 | 9 | 0 | 7 | 3.9 | CCCN(CCOC)c1cc(C)nc2c(-c3ccc(OC)c(OC)c3)c(C)nn12 | 10.1021/jm990590f | |||
| CHEMBL297886 | 108266 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 398 | 9 | 0 | 7 | 3.9 | CCCN(CCOC)c1cc(C)nc2c(-c3ccc(OC)c(OC)c3)c(C)nn12 | 10.1021/jm990590f | |||
| 44266481 | 12144 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 427 | 6 | 0 | 5 | 5.4 | CCN(c1nc(C)cc(-c2ccccc2)n1)c1c(Br)cc(OC)cc1OC | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL10698 | 12144 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 427 | 6 | 0 | 5 | 5.4 | CCN(c1nc(C)cc(-c2ccccc2)n1)c1c(Br)cc(OC)cc1OC | 10.1016/s0960-894x(99)00132-8 | |||
| 122193806 | 130754 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 8 | 0 | 4 | 6.0 | CCN(C)c1cc(C)nc2c1N(CCCCF)C(=O)CN2c1ccc(C(C)C)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628854 | 130754 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 8 | 0 | 4 | 6.0 | CCN(C)c1cc(C)nc2c1N(CCCCF)C(=O)CN2c1ccc(C(C)C)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL2372939 | 217099 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)C(CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm034180+ | |||||
| 9800789 | 129919 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 394 | 7 | 0 | 6 | 4.3 | CCCC(CCC)N1CCn2c(=O)n(-c3cccc(OC)c3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL361242 | 129919 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 394 | 7 | 0 | 6 | 4.3 | CCCC(CCC)N1CCn2c(=O)n(-c3cccc(OC)c3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 44384828 | 66535 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 491 | 9 | 0 | 8 | 3.4 | COCCN(CCOC)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL172544 | 66535 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 491 | 9 | 0 | 8 | 3.4 | COCCN(CCOC)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 21916340 | 14152 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 502 | 8 | 0 | 4 | 7.5 | CCCCN(Cc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1086380 | 14152 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 502 | 8 | 0 | 4 | 7.5 | CCCCN(Cc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 10616216 | 110327 | 1 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 327 | 7 | 1 | 5 | 4.5 | CCCN(CCC)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960148m | |||
| CHEMBL308544 | 110327 | 1 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 327 | 7 | 1 | 5 | 4.5 | CCCN(CCC)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960148m | |||
| 10616216 | 110327 | 1 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 327 | 7 | 1 | 5 | 4.5 | CCCN(CCC)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm9900117 | |||
| CHEMBL308544 | 110327 | 1 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 327 | 7 | 1 | 5 | 4.5 | CCCN(CCC)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm9900117 | |||
| 10186078 | 71358 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 513 | 8 | 1 | 5 | 8.3 | CCCN(Cc1cccs1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181625 | 71358 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 513 | 8 | 1 | 5 | 8.3 | CCCN(Cc1cccs1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 18672249 | 71369 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 575 | 9 | 1 | 4 | 8.9 | FC(F)(F)CCN(CCc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181673 | 71369 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 575 | 9 | 1 | 4 | 8.9 | FC(F)(F)CCN(CCc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 20780053 | 175728 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 497 | 6 | 0 | 5 | 6.8 | Cc1cc(C)c(-n2c3ncccc3n3c(CN4CCCC4CCc4ccccc4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL438847 | 175728 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 497 | 6 | 0 | 5 | 6.8 | Cc1cc(C)c(-n2c3ncccc3n3c(CN4CCCC4CCc4ccccc4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| 10229290 | 137198 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 508 | 8 | 1 | 5 | 7.7 | CCCN(Cc1ccccn1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL368018 | 137198 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 508 | 8 | 1 | 5 | 7.7 | CCCN(Cc1ccccn1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 44389082 | 69323 | 0 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 500 | 9 | 1 | 5 | 6.6 | CN(C)CCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL178246 | 69323 | 0 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 500 | 9 | 1 | 5 | 6.6 | CN(C)CCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| 11340431 | 80167 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 7 | 1 | 5 | 6.5 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2cccc(OCc3ccccc3)c2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL201518 | 80167 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 472 | 7 | 1 | 5 | 6.5 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2cccc(OCc3ccccc3)c2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| 11798911 | 127131 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 479 | 9 | 0 | 7 | 6.1 | CCCCN(CC)c1nc(C)nc2c1nc(-c1ccccc1)n2-c1c(Cl)cc(OC)cc1OC | 10.1021/jm980224g | |||
| CHEMBL353098 | 127131 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 479 | 9 | 0 | 7 | 6.1 | CCCCN(CC)c1nc(C)nc2c1nc(-c1ccccc1)n2-c1c(Cl)cc(OC)cc1OC | 10.1021/jm980224g | |||
| 44318119 | 212679 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 341 | 6 | 0 | 4 | 4.3 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2C)n(C)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL83934 | 212679 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 341 | 6 | 0 | 4 | 4.3 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2C)n(C)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 20780073 | 74059 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 452 | 7 | 0 | 4 | 6.4 | C=CCN(CC=C)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL188194 | 74059 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 452 | 7 | 0 | 4 | 6.4 | C=CCN(CC=C)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 10830877 | 212293 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 338 | 7 | 1 | 4 | 5.1 | CCCN(CC1CC1)c1cc(Nc2c(C)cc(C)cc2C)nc(C)n1 | 10.1021/jm960149e | |||
| CHEMBL80806 | 212293 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 338 | 7 | 1 | 4 | 5.1 | CCCN(CC1CC1)c1cc(Nc2c(C)cc(C)cc2C)nc(C)n1 | 10.1021/jm960149e | |||
| 10830877 | 212293 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 338 | 7 | 1 | 4 | 5.1 | CCCN(CC1CC1)c1cc(Nc2c(C)cc(C)cc2C)nc(C)n1 | 10.1021/jm9900117 | |||
| CHEMBL80806 | 212293 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 338 | 7 | 1 | 4 | 5.1 | CCCN(CC1CC1)c1cc(Nc2c(C)cc(C)cc2C)nc(C)n1 | 10.1021/jm9900117 | |||
| 10506052 | 64220 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 516 | 8 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc(N(CC)c2ccc(I)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL165531 | 64220 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 516 | 8 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc(N(CC)c2ccc(I)cc2Br)n1 | 10.1021/jm980222w | |||
| 10529311 | 64302 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 496 | 10 | 0 | 5 | 6.5 | CCN(c1nc(C)cc(N(CCOC)Cc2ccccc2)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980222w | |||
| CHEMBL166235 | 64302 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 496 | 10 | 0 | 5 | 6.5 | CCN(c1nc(C)cc(N(CCOC)Cc2ccccc2)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980222w | |||
| 44392657 | 71986 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 382 | 7 | 0 | 7 | 4.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(C)cc3[N+](=O)[O-])c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL182567 | 71986 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 382 | 7 | 0 | 7 | 4.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(C)cc3[N+](=O)[O-])c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 10346761 | 117380 | 1 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 524 | 7 | 1 | 4 | 6.7 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(I)cc2Cl)c1Cl | 10.1016/s0960-894x(00)00661-2 | |||
| CHEMBL325577 | 117380 | 1 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 524 | 7 | 1 | 4 | 6.7 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(I)cc2Cl)c1Cl | 10.1016/s0960-894x(00)00661-2 | |||
| 21916292 | 14274 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 524 | 7 | 0 | 4 | 6.8 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN(CC2CC2)CC(F)(F)C(F)(F)F)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1087166 | 14274 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 524 | 7 | 0 | 4 | 6.8 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN(CC2CC2)CC(F)(F)C(F)(F)F)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| 11442212 | 69271 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 446 | 8 | 0 | 5 | 6.2 | CCCN(c1nc(-c2ccc(OC)cc2C)n(C)n1)C(CC)c1ccc(C(F)(F)F)cc1 | 10.1021/jm049339c | |||
| CHEMBL178117 | 69271 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 446 | 8 | 0 | 5 | 6.2 | CCCN(c1nc(-c2ccc(OC)cc2C)n(C)n1)C(CC)c1ccc(C(F)(F)F)cc1 | 10.1021/jm049339c | |||
| 11212115 | 129105 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 412 | 9 | 0 | 5 | 5.9 | CCCC(c1ccccc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL359863 | 129105 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 412 | 9 | 0 | 5 | 5.9 | CCCC(c1ccccc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 44337106 | 13025 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 356 | 8 | 1 | 5 | 3.9 | CCCN(CCC)c1nc(-c2ccc(Cl)cc2Cl)n(CCO)n1 | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL108158 | 13025 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 356 | 8 | 1 | 5 | 3.9 | CCCN(CCC)c1nc(-c2ccc(Cl)cc2Cl)n(CCO)n1 | 10.1016/s0960-894x(01)00657-6 | |||
| 122193726 | 130744 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 474 | 6 | 0 | 4 | 5.4 | Cc1cc(N(C)C)c2c(n1)N(c1ccc(C(C)C)cc1Br)CC(=O)N2C/C=C/CF | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628745 | 130744 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 474 | 6 | 0 | 4 | 5.4 | Cc1cc(N(C)C)c2c(n1)N(c1ccc(C(C)C)cc1Br)CC(=O)N2C/C=C/CF | 10.1016/j.bmcl.2015.10.010 | |||
| 9946605 | 70777 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 353 | 6 | 1 | 4 | 5.4 | CCC(CC)Nc1nc(OC)c(-c2ccc(Cl)cc2Cl)nc1C | 10.1021/jm200365y | |||
| CHEMBL1807043 | 70777 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 353 | 6 | 1 | 4 | 5.4 | CCC(CC)Nc1nc(OC)c(-c2ccc(Cl)cc2Cl)nc1C | 10.1021/jm200365y | |||
| 9957428 | 68053 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 494 | 9 | 0 | 8 | 4.1 | COCCN(CCOC)c1nc(C)nc2c1sc(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00159-6 | |||
| CHEMBL17666 | 68053 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 494 | 9 | 0 | 8 | 4.1 | COCCN(CCOC)c1nc(C)nc2c1sc(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00159-6 | |||
| 9798798 | 69926 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 356 | 4 | 0 | 6 | 3.9 | CCN(CC)c1nc(C)nc2c1sc(=O)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00159-6 | |||
| CHEMBL17897 | 69926 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 356 | 4 | 0 | 6 | 3.9 | CCN(CC)c1nc(C)nc2c1sc(=O)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00159-6 | |||
| 44341687 | 118093 | 1 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 378 | 8 | 0 | 4 | 5.9 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL326722 | 118093 | 1 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 378 | 8 | 0 | 4 | 5.9 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 11475328 | 132965 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 408 | 8 | 0 | 6 | 4.7 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(OCC)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL364938 | 132965 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 408 | 8 | 0 | 6 | 4.7 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(OCC)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 44341634 | 17030 | 1 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 317 | 2 | 0 | 2 | 5.5 | COc1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL116106 | 17030 | 1 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 317 | 2 | 0 | 2 | 5.5 | COc1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 20780054 | 175909 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 409 | 3 | 0 | 6 | 4.1 | Cc1cc(C)c(-n2c3ncccc3n3c(CN4CCOCC4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL440232 | 175909 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 409 | 3 | 0 | 6 | 4.1 | Cc1cc(C)c(-n2c3ncccc3n3c(CN4CCOCC4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| 11109264 | 109336 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 297 | 5 | 2 | 4 | 3.4 | COc1cccc(N/C(=N/Nc2ccccc2C)C(C)=O)c1 | 10.1021/jm025512y | |||
| CHEMBL304072 | 109336 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 297 | 5 | 2 | 4 | 3.4 | COc1cccc(N/C(=N/Nc2ccccc2C)C(C)=O)c1 | 10.1021/jm025512y | |||
| 20780180 | 73978 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 468 | 7 | 0 | 4 | 6.8 | CCN(CCC1CC1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL187815 | 73978 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 468 | 7 | 0 | 4 | 6.8 | CCN(CCC1CC1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 11782614 | 210738 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 335 | 4 | 2 | 3 | 4.3 | CC(=O)/C(=N\c1cccc(C)c1)NNc1ccccc1C(F)(F)F | 10.1021/jm025512y | |||
| CHEMBL69374 | 210738 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 335 | 4 | 2 | 3 | 4.3 | CC(=O)/C(=N\c1cccc(C)c1)NNc1ccccc1C(F)(F)F | 10.1021/jm025512y | |||
| 44308156 | 109108 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 420 | 7 | 0 | 6 | 4.4 | CCCN(CCN(C)C)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL303639 | 109108 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 420 | 7 | 0 | 6 | 4.4 | CCCN(CCN(C)C)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 11245983 | 82688 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 380 | 4 | 1 | 4 | 5.2 | Cc1ccc(S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL204967 | 82688 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 380 | 4 | 1 | 4 | 5.2 | Cc1ccc(S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2005.10.097 | |||
| 1799083 | 210792 | 3 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 365 | 4 | 2 | 3 | 4.3 | CC(=O)/C(=N\c1cccc(Cl)c1)NNc1ccc(Br)cc1 | 10.1021/jm025512y | |||
| CHEMBL69686 | 210792 | 3 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 365 | 4 | 2 | 3 | 4.3 | CC(=O)/C(=N\c1cccc(Cl)c1)NNc1ccc(Br)cc1 | 10.1021/jm025512y | |||
| 10594766 | 109913 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.9 | CCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960148m | |||
| CHEMBL307871 | 109913 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.9 | CCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960148m | |||
| 10594766 | 109913 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.9 | CCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm9900117 | |||
| CHEMBL307871 | 109913 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.9 | CCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm9900117 | |||
| 22324320 | 212727 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 381 | 7 | 0 | 4 | 5.2 | CCCN(CCC)c1c(C)nc(-c2ccc(Cl)cc2Cl)n(CC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL84339 | 212727 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 381 | 7 | 0 | 4 | 5.2 | CCCN(CCC)c1c(C)nc(-c2ccc(Cl)cc2Cl)n(CC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 10596113 | 127364 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 382 | 7 | 0 | 5 | 5.1 | CCN(CC)c1cc(C)nc(N(CC)c2c(Cl)cc(OC)cc2Cl)n1 | 10.1021/jm980222w | |||
| CHEMBL354584 | 127364 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 382 | 7 | 0 | 5 | 5.1 | CCN(CC)c1cc(C)nc(N(CC)c2c(Cl)cc(OC)cc2Cl)n1 | 10.1021/jm980222w | |||
| 10474043 | 71351 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 365 | 7 | 0 | 4 | 4.9 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL181593 | 71351 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 365 | 7 | 0 | 4 | 4.9 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 4183319 | 121527 | 1 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 352 | 7 | 0 | 5 | 4.6 | CCCN(CCC)c1cc(C)nc2c(-c3ccccc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL333880 | 121527 | 1 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 352 | 7 | 0 | 5 | 4.6 | CCCN(CCC)c1cc(C)nc2c(-c3ccccc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 44306488 | 209528 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 395 | 9 | 0 | 5 | 5.2 | CCCN(c1ncc(C)c(-c2c(C)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL61954 | 209528 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 395 | 9 | 0 | 5 | 5.2 | CCCN(c1ncc(C)c(-c2c(C)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| 9865575 | 210176 | 1 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 397 | 10 | 0 | 6 | 4.6 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL65484 | 210176 | 1 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 397 | 10 | 0 | 6 | 4.6 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| 44308017 | 109308 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 379 | 7 | 0 | 5 | 5.4 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(C)cc3C)nn(CC)c12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL304059 | 109308 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 379 | 7 | 0 | 5 | 5.4 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(C)cc3C)nn(CC)c12 | 10.1016/s0960-894x(02)00358-x | |||
| 44305208 | 107523 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 356 | 6 | 0 | 4 | 5.3 | CCCCN(CC)c1cc(C)nc2c(-c3ccccc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| CHEMBL292764 | 107523 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 356 | 6 | 0 | 4 | 5.3 | CCCCN(CC)c1cc(C)nc2c(-c3ccccc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| 20780153 | 100536 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 449 | 8 | 0 | 5 | 6.3 | CCCN(CCC1CC1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL247359 | 100536 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 449 | 8 | 0 | 5 | 6.3 | CCCN(CCC1CC1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 20780142 | 151841 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 415 | 7 | 0 | 5 | 5.5 | CCCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12)CC1CC1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL391141 | 151841 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 415 | 7 | 0 | 5 | 5.5 | CCCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12)CC1CC1 | 10.1016/j.bmcl.2007.01.008 | |||
| 20780165 | 154538 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 423 | 7 | 0 | 5 | 5.9 | CCCN(CCC)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL393250 | 154538 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 423 | 7 | 0 | 5 | 5.9 | CCCN(CCC)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 10132995 | 194770 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 357 | 8 | 0 | 5 | 4.7 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL497301 | 194770 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 357 | 8 | 0 | 5 | 4.7 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| 11375016 | 130856 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 478 | 7 | 0 | 6 | 6.4 | CCCN(Cc1ccc2ccccc2c1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL363269 | 130856 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 478 | 7 | 0 | 6 | 6.4 | CCCN(Cc1ccc2ccccc2c1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 44337304 | 116660 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 396 | 7 | 0 | 4 | 5.3 | CCCN(c1nc(-c2cc(F)c(Cl)cc2Cl)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL323437 | 116660 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 396 | 7 | 0 | 4 | 5.3 | CCCN(c1nc(-c2cc(F)c(Cl)cc2Cl)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| 44387103 | 68560 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 5.7 | CCCCC(CC)Nc1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL177310 | 68560 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 5.7 | CCCCC(CC)Nc1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 10717531 | 65284 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 430 | 10 | 0 | 9 | 3.5 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1SC | 10.1021/jm980224g | |||
| CHEMBL168388 | 65284 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 430 | 10 | 0 | 9 | 3.5 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1SC | 10.1021/jm980224g | |||
| 10812125 | 65909 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 421 | 7 | 0 | 7 | 4.2 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1ccc(N(C)C)cc1C(F)(F)F | 10.1021/jm980224g | |||
| CHEMBL169862 | 65909 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 421 | 7 | 0 | 7 | 4.2 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1ccc(N(C)C)cc1C(F)(F)F | 10.1021/jm980224g | |||
| 11656502 | 77972 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 402 | 4 | 0 | 4 | 6.0 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1CC(C)C | 10.1021/jm049085v | |||
| CHEMBL195636 | 77972 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 402 | 4 | 0 | 4 | 6.0 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1CC(C)C | 10.1021/jm049085v | |||
| 11361057 | 74446 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 382 | 6 | 0 | 7 | 3.1 | CCCC(OC)N1CCn2c(=O)n(-c3ccc(OC)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL190757 | 74446 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 382 | 6 | 0 | 7 | 3.1 | CCCC(OC)N1CCn2c(=O)n(-c3ccc(OC)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 21916165 | 74005 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 446 | 8 | 0 | 4 | 6.5 | CCCN(Cc1c(CC)nc2n(-c3c(C)cc(C)cc3C)c3ccc(F)cc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL187940 | 74005 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 446 | 8 | 0 | 4 | 6.5 | CCCN(Cc1c(CC)nc2n(-c3c(C)cc(C)cc3C)c3ccc(F)cc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| 44397642 | 74332 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 546 | 8 | 0 | 4 | 7.8 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3ccc(C(C)C)cc3Br)c3ccccc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL189809 | 74332 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 546 | 8 | 0 | 4 | 7.8 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3ccc(C(C)C)cc3Br)c3ccccc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| 44347117 | 23219 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 466 | 7 | 0 | 6 | 5.0 | CCCN(CC1CC1)c1cc(S(C)(=O)=O)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL123306 | 23219 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 466 | 7 | 0 | 6 | 5.0 | CCCN(CC1CC1)c1cc(S(C)(=O)=O)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 21916109 | 13478 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 533 | 8 | 0 | 6 | 7.0 | CCCN(Cc1ccc([N+](=O)[O-])cc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083612 | 13478 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 533 | 8 | 0 | 6 | 7.0 | CCCN(Cc1ccc([N+](=O)[O-])cc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 21916289 | 13648 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 474 | 6 | 0 | 4 | 6.4 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(C)CCc4ccccc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1084184 | 13648 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 474 | 6 | 0 | 4 | 6.4 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(C)CCc4ccccc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 10502620 | 126197 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 426 | 7 | 0 | 4 | 6.4 | CCCN(CC1CC1)c1nc(C)nc(N(C)c2c(Cl)cc(Cl)cc2Cl)c1C | 10.1021/jm960149e | |||
| CHEMBL344805 | 126197 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 426 | 7 | 0 | 4 | 6.4 | CCCN(CC1CC1)c1nc(C)nc(N(C)c2c(Cl)cc(Cl)cc2Cl)c1C | 10.1021/jm960149e | |||
| 10275456 | 70151 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 7.1 | CCCN(CC)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL179576 | 70151 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 445 | 7 | 1 | 4 | 7.1 | CCCN(CC)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 11429073 | 69392 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 384 | 7 | 0 | 5 | 5.1 | CCC(c1ccccc1)N(CC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL178346 | 69392 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 384 | 7 | 0 | 5 | 5.1 | CCC(c1ccccc1)N(CC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 44337446 | 11972 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 420 | 8 | 0 | 4 | 5.8 | CCCN(c1nc(-c2c(C)cc(C)cc2C)n(CC(F)(F)F)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL106093 | 11972 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 420 | 8 | 0 | 4 | 5.8 | CCCN(c1nc(-c2c(C)cc(C)cc2C)n(CC(F)(F)F)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| 22248956 | 70770 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 381 | 8 | 1 | 4 | 6.0 | CCOc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1807036 | 70770 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 381 | 8 | 1 | 4 | 6.0 | CCOc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 46881398 | 14277 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 408 | 3 | 0 | 5 | 4.2 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN2CCOCC2)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1087173 | 14277 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 408 | 3 | 0 | 5 | 4.2 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN2CCOCC2)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| 22249081 | 70761 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 408 | 9 | 0 | 4 | 5.4 | CCCN(CCN(C)C)c1nc(CC)c(-c2ccc(Cl)cc2Cl)nc1CC | 10.1021/jm200365y | |||
| CHEMBL1807027 | 70761 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 408 | 9 | 0 | 4 | 5.4 | CCCN(CCN(C)C)c1nc(CC)c(-c2ccc(Cl)cc2Cl)nc1CC | 10.1021/jm200365y | |||
| 44460260 | 212117 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | Cc1ccccc1[C@@H](Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| CHEMBL79587 | 212117 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | Cc1ccccc1[C@@H](Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| 44443575 | 100761 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 414 | 8 | 2 | 4 | 6.9 | CCc1nc(NC(CC)CC)c(CC)nc1Nc1c(Cl)cc(Cl)cc1Cl | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL248585 | 100761 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 414 | 8 | 2 | 4 | 6.9 | CCc1nc(NC(CC)CC)c(CC)nc1Nc1c(Cl)cc(Cl)cc1Cl | 10.1016/j.bmcl.2007.09.008 | |||
| 20780024 | 71999 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 472 | 8 | 0 | 4 | 5.7 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n1CCN2c1ccc(C(C)C)cc1Br | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL182624 | 71999 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 472 | 8 | 0 | 4 | 5.7 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n1CCN2c1ccc(C(C)C)cc1Br | 10.1016/j.bmcl.2005.05.117 | |||
| 11454794 | 82384 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 497 | 7 | 1 | 6 | 6.3 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCc3ccc(C#N)cc3)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL204706 | 82384 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 497 | 7 | 1 | 6 | 6.3 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCc3ccc(C#N)cc3)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| 11704536 | 78540 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 424 | 5 | 0 | 6 | 4.9 | CC[C@H]1Cn2nc(-c3ccc(C(=O)OC)cc3Cl)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL196682 | 78540 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 424 | 5 | 0 | 6 | 4.9 | CC[C@H]1Cn2nc(-c3ccc(C(=O)OC)cc3Cl)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 9843989 | 78694 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 400 | 2 | 0 | 4 | 5.9 | Cc1cc2c3c(n1)c(-c1ccc(Cl)cc1Cl)nn3CCN2C1CCCCC1 | 10.1021/jm049085v | |||
| CHEMBL197204 | 78694 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 400 | 2 | 0 | 4 | 5.9 | Cc1cc2c3c(n1)c(-c1ccc(Cl)cc1Cl)nn3CCN2C1CCCCC1 | 10.1021/jm049085v | |||
| 11524923 | 131584 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 436 | 4 | 0 | 4 | 6.5 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1Cc1ccccc1 | 10.1021/jm049085v | |||
| CHEMBL364261 | 131584 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 436 | 4 | 0 | 4 | 6.5 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1Cc1ccccc1 | 10.1021/jm049085v | |||
| 44352386 | 25734 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 451 | 8 | 1 | 4 | 7.1 | CCCN(Cc1sc(Nc2c(C)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL128709 | 25734 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 451 | 8 | 1 | 4 | 7.1 | CCCN(Cc1sc(Nc2c(C)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 44341635 | 16773 | 1 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 333 | 2 | 0 | 2 | 6.2 | CSc1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL114914 | 16773 | 1 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 333 | 2 | 0 | 2 | 6.2 | CSc1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 46891210 | 13410 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 506 | 7 | 0 | 4 | 6.9 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCC(F)(F)F)CC4CC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083320 | 13410 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 506 | 7 | 0 | 4 | 6.9 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCC(F)(F)F)CC4CC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 20780253 | 13721 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 452 | 6 | 0 | 4 | 6.3 | CCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12)CC1CCC1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1084511 | 13721 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 452 | 6 | 0 | 4 | 6.3 | CCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12)CC1CCC1 | 10.1016/j.bmcl.2010.04.094 | |||
| 44307870 | 210322 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 377 | 5 | 1 | 5 | 5.2 | CCC(CC)Nc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL66492 | 210322 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 377 | 5 | 1 | 5 | 5.2 | CCC(CC)Nc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 44307654 | 210346 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 6 | 1 | 4 | 4.8 | CCCN(CCC)c1[nH]c(C)nc2c(-c3c(C)cc(C)cc3C)nnc1-2 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL66719 | 210346 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 6 | 1 | 4 | 4.8 | CCCN(CCC)c1[nH]c(C)nc2c(-c3c(C)cc(C)cc3C)nnc1-2 | 10.1016/s0960-894x(02)00358-x | |||
| 21916343 | 100155 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 469 | 7 | 0 | 5 | 6.2 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12)CC1CC1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL245671 | 100155 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 469 | 7 | 0 | 5 | 6.2 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12)CC1CC1 | 10.1016/j.bmcl.2007.01.008 | |||
| 44587491 | 194898 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 371 | 9 | 0 | 5 | 5.1 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)nc1OCC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL498318 | 194898 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 371 | 9 | 0 | 5 | 5.1 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)nc1OCC | 10.1016/j.bmcl.2008.07.063 | |||
| 11235868 | 141962 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 397 | 5 | 0 | 4 | 5.4 | CCC(COC)N1CCc2cn(-c3c(C)cc(Cl)cc3C)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL372009 | 141962 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 397 | 5 | 0 | 4 | 5.4 | CCC(COC)N1CCc2cn(-c3c(C)cc(Cl)cc3C)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 44341452 | 16287 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 446 | 9 | 0 | 4 | 7.7 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C(C)C)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL112151 | 16287 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 446 | 9 | 0 | 4 | 7.7 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C(C)C)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| 9843717 | 73552 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 396 | 6 | 0 | 6 | 4.7 | CCCN(CC1CC1)c1nc(C)nc2c1sc(=O)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00159-6 | |||
| CHEMBL18590 | 73552 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 396 | 6 | 0 | 6 | 4.7 | CCCN(CC1CC1)c1nc(C)nc2c1sc(=O)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00159-6 | |||
| 11166649 | 113202 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 442 | 10 | 0 | 6 | 5.9 | CCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2cc(OC)c(OC)cc2Cl)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL3085418 | 113202 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 442 | 10 | 0 | 6 | 5.9 | CCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2cc(OC)c(OC)cc2Cl)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL3139572 | 113202 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 442 | 10 | 0 | 6 | 5.9 | CCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2cc(OC)c(OC)cc2Cl)n(C)n1 | 10.1021/jm049339c | |||
| 122193722 | 130741 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 416 | 4 | 1 | 4 | 4.8 | CCN(C)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628742 | 130741 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 416 | 4 | 1 | 4 | 4.8 | CCN(C)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| 135444727 | 127002 | 0 | None | -3 | 2 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 428 | 3 | 4 | 7 | 2.4 | NCCNC(=O)c1c2c(c3c(O)c4ccccc4c4ncnc1c34)=N[C@@H]1CCCC[C@H]1N2 | 10.1016/s0960-894x(99)00075-x | |||
| CHEMBL352154 | 127002 | 0 | None | -3 | 2 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 428 | 3 | 4 | 7 | 2.4 | NCCNC(=O)c1c2c(c3c(O)c4ccccc4c4ncnc1c34)=N[C@@H]1CCCC[C@H]1N2 | 10.1016/s0960-894x(99)00075-x | |||
| 21916299 | 13178 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 460 | 5 | 0 | 4 | 6.4 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(C)Cc4ccccc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1082339 | 13178 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 460 | 5 | 0 | 4 | 6.4 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(C)Cc4ccccc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 21916288 | 13471 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 546 | 6 | 0 | 4 | 7.4 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(Cc4ccc(F)cc4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083593 | 13471 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 546 | 6 | 0 | 4 | 7.4 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(Cc4ccc(F)cc4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 10276375 | 70050 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 459 | 8 | 1 | 4 | 7.5 | CCCN(CCC)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL179225 | 70050 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 459 | 8 | 1 | 4 | 7.5 | CCCN(CCC)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 20780156 | 130453 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 544 | 8 | 0 | 4 | 8.1 | CCCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3ccc(Cl)cc3Cl)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL362124 | 130453 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 544 | 8 | 0 | 4 | 8.1 | CCCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3ccc(Cl)cc3Cl)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 46891009 | 13207 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 438 | 3 | 0 | 4 | 6.1 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCCCC4C)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1082442 | 13207 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 438 | 3 | 0 | 4 | 6.1 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCCCC4C)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 10273816 | 26150 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 421 | 7 | 1 | 5 | 5.3 | CCN(CCOC)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL129196 | 26150 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 421 | 7 | 1 | 5 | 5.3 | CCN(CCOC)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C | 10.1016/j.bmcl.2003.08.055 | |||
| 44587372 | 194768 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 387 | 10 | 1 | 6 | 4.1 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)nc1OCCO | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL497286 | 194768 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 387 | 10 | 1 | 6 | 4.1 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)nc1OCCO | 10.1016/j.bmcl.2008.07.063 | |||
| 44462061 | 113368 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 425 | 8 | 0 | 5 | 5.0 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)n(CC(F)(F)F)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL314267 | 113368 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 425 | 8 | 0 | 5 | 5.0 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)n(CC(F)(F)F)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 44446732 | 101644 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 334 | 5 | 1 | 3 | 5.7 | CCCNc1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL253915 | 101644 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 334 | 5 | 1 | 3 | 5.7 | CCCNc1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 22249005 | 70766 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 355 | 6 | 1 | 3 | 5.8 | CCc1nc(NC(CC)CC)c(F)nc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| CHEMBL1807032 | 70766 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 355 | 6 | 1 | 3 | 5.8 | CCc1nc(NC(CC)CC)c(F)nc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| 44446717 | 162210 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 6 | 0 | 2 | 6.5 | CCCN(CCC)c1c(C)nc(-c2ccccc2Cl)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL403745 | 162210 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 6 | 0 | 2 | 6.5 | CCCN(CCC)c1c(C)nc(-c2ccccc2Cl)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 10787219 | 211950 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 401 | 5 | 2 | 5 | 5.5 | Cc1cc(C)c(Nc2nc(C)nc(NCc3ccc(C(F)(F)F)cc3)n2)c(C)c1 | 10.1021/jm960148m | |||
| CHEMBL78271 | 211950 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 401 | 5 | 2 | 5 | 5.5 | Cc1cc(C)c(Nc2nc(C)nc(NCc3ccc(C(F)(F)F)cc3)n2)c(C)c1 | 10.1021/jm960148m | |||
| 10787219 | 211950 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 401 | 5 | 2 | 5 | 5.5 | Cc1cc(C)c(Nc2nc(C)nc(NCc3ccc(C(F)(F)F)cc3)n2)c(C)c1 | 10.1021/jm9900117 | |||
| CHEMBL78271 | 211950 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 401 | 5 | 2 | 5 | 5.5 | Cc1cc(C)c(Nc2nc(C)nc(NCc3ccc(C(F)(F)F)cc3)n2)c(C)c1 | 10.1021/jm9900117 | |||
| 9954503 | 74326 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 432 | 6 | 0 | 5 | 5.3 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(C(F)(F)F)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL189780 | 74326 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 432 | 6 | 0 | 5 | 5.3 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(C(F)(F)F)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 10669045 | 64914 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 405 | 7 | 0 | 6 | 4.1 | CCN(CC)c1nc(C)nc(N(CC)c2ccc(C(C)=O)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL167853 | 64914 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 405 | 7 | 0 | 6 | 4.1 | CCN(CC)c1nc(C)nc(N(CC)c2ccc(C(C)=O)cc2Br)n1 | 10.1021/jm980222w | |||
| 10647940 | 127501 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 466 | 8 | 0 | 4 | 6.9 | CCN(Cc1ccccc1)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL354791 | 127501 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 466 | 8 | 0 | 4 | 6.9 | CCN(Cc1ccccc1)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 44392709 | 136674 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 420 | 7 | 0 | 6 | 5.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N4CCCCC4)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL367583 | 136674 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 420 | 7 | 0 | 6 | 5.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N4CCCCC4)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 44308187 | 210831 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 375 | 3 | 1 | 5 | 5.0 | Cc1nc(NC2CCCC2)c2nn(C)c(-c3ccc(Cl)cc3Cl)c2n1 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL69968 | 210831 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 375 | 3 | 1 | 5 | 5.0 | Cc1nc(NC2CCCC2)c2nn(C)c(-c3ccc(Cl)cc3Cl)c2n1 | 10.1016/s0960-894x(02)00358-x | |||
| 20780144 | 157768 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 8 | 0 | 5 | 6.2 | CCCN(Cc1c(CC)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12)CC1CCC1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL395833 | 157768 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 8 | 0 | 5 | 6.2 | CCCN(Cc1c(CC)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12)CC1CCC1 | 10.1016/j.bmcl.2007.01.008 | |||
| 11454873 | 147533 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 502 | 8 | 1 | 6 | 6.5 | COc1ccccc1COc1ccc(S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL381824 | 147533 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 502 | 8 | 1 | 6 | 6.5 | COc1ccccc1COc1ccc(S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2005.10.097 | |||
| 44446724 | 101582 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 414 | 9 | 0 | 4 | 6.4 | CCCN(CCC)c1c(C)nc(-c2ccc(OC(F)F)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL253493 | 101582 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 414 | 9 | 0 | 4 | 6.4 | CCCN(CCC)c1c(C)nc(-c2ccc(OC(F)F)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 11485413 | 172934 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 366 | 5 | 1 | 6 | 4.2 | Cc1cc(NC(C)C(C)C)n2nc(C)c(-c3cnc(N(C)C)cc3C)c2n1 | 10.1021/jm040058e | |||
| CHEMBL426260 | 172934 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 366 | 5 | 1 | 6 | 4.2 | Cc1cc(NC(C)C(C)C)n2nc(C)c(-c3cnc(N(C)C)cc3C)c2n1 | 10.1021/jm040058e | |||
| 22249061 | 70754 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 9 | 1 | 7 | 3.7 | CCc1nc(-c2cnc(OC)nc2OC)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1807020 | 70754 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 9 | 1 | 7 | 3.7 | CCc1nc(-c2cnc(OC)nc2OC)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 44384750 | 138579 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 395 | 7 | 1 | 6 | 4.7 | CCCCC(CC)Nc1nc(C)nc2c1n(C)c(=O)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL369371 | 138579 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 395 | 7 | 1 | 6 | 4.7 | CCCCC(CC)Nc1nc(C)nc2c1n(C)c(=O)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00108-0 | |||
| 44266437 | 215187 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 477 | 5 | 0 | 3 | 7.5 | CCN(c1nc(C)cc(-c2cccc(C(F)(F)F)c2)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL9975 | 215187 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 477 | 5 | 0 | 3 | 7.5 | CCN(c1nc(C)cc(-c2cccc(C(F)(F)F)c2)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 11429605 | 131315 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 404 | 4 | 0 | 5 | 4.5 | CCC(CC)N1CCn2c(=O)n(-c3ccc(C(F)(F)F)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL364037 | 131315 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 404 | 4 | 0 | 5 | 4.5 | CCC(CC)N1CCn2c(=O)n(-c3ccc(C(F)(F)F)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 44341983 | 16311 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 5.5 | CCCCNc1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL112266 | 16311 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 5.5 | CCCCNc1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 21916286 | 13475 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 488 | 7 | 0 | 4 | 7.1 | CCCN(Cc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083608 | 13475 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 488 | 7 | 0 | 4 | 7.1 | CCCN(Cc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 46891057 | 14055 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 426 | 3 | 0 | 5 | 4.6 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCOCC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1086016 | 14055 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 426 | 3 | 0 | 5 | 4.6 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCOCC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 20780039 | 13462 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 444 | 7 | 0 | 4 | 5.8 | CCCN(CCc1ccccc1)C(=O)c1c(C)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1083513 | 13462 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 444 | 7 | 0 | 4 | 5.8 | CCCN(CCc1ccccc1)C(=O)c1c(C)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| 10785716 | 35064 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 375 | 8 | 1 | 5 | 5.1 | CCc1cccc(CC)c1Nc1nc(C)nc(N(CC)Cc2ccccc2)n1 | 10.1021/jm960148m | |||
| CHEMBL137434 | 35064 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 375 | 8 | 1 | 5 | 5.1 | CCc1cccc(CC)c1Nc1nc(C)nc(N(CC)Cc2ccccc2)n1 | 10.1021/jm960148m | |||
| 44446737 | 162387 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 459 | 10 | 0 | 4 | 6.9 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OCCN2CCCC2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL404559 | 162387 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 459 | 10 | 0 | 4 | 6.9 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OCCN2CCCC2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 44443658 | 161698 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 489 | 9 | 2 | 6 | 6.1 | CCc1nc(N[C@@H]2c3ccccc3C[C@@H]2OCCF)c(CC)nc1Nc1ncc(Cl)cc1Cl | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL400952 | 161698 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 489 | 9 | 2 | 6 | 6.1 | CCc1nc(N[C@@H]2c3ccccc3C[C@@H]2OCCF)c(CC)nc1Nc1ncc(Cl)cc1Cl | 10.1016/j.bmcl.2007.09.008 | |||
| 44307479 | 210334 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 389 | 3 | 1 | 5 | 5.4 | Cc1nc(NC2CCCCC2)c2nn(C)c(-c3ccc(Cl)cc3Cl)c2n1 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL66631 | 210334 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 389 | 3 | 1 | 5 | 5.4 | Cc1nc(NC2CCCCC2)c2nn(C)c(-c3ccc(Cl)cc3Cl)c2n1 | 10.1016/s0960-894x(02)00358-x | |||
| 44407869 | 81892 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 394 | 4 | 1 | 4 | 5.5 | Cc1ccc(S(=O)(=O)c2c(C)cc(C)nc2Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL203609 | 81892 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 394 | 4 | 1 | 4 | 5.5 | Cc1ccc(S(=O)(=O)c2c(C)cc(C)nc2Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2005.10.097 | |||
| 44379386 | 127531 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 11 | 0 | 7 | 4.3 | CCN(c1nc(C)nc(N(CCOC)CCOC)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980222w | |||
| CHEMBL355055 | 127531 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 465 | 11 | 0 | 7 | 4.3 | CCN(c1nc(C)nc(N(CCOC)CCOC)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980222w | |||
| 44341823 | 16778 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 434 | 9 | 0 | 5 | 5.9 | CCCCN(CCCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL114928 | 16778 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 434 | 9 | 0 | 5 | 5.9 | CCCCN(CCCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 20780123 | 202391 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 451 | 9 | 0 | 5 | 6.7 | CCCCN(CCCC)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL556060 | 202391 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 451 | 9 | 0 | 5 | 6.7 | CCCCN(CCCC)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 44379486 | 126810 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 6.5 | CCCCN(CC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm049737f | |||
| CHEMBL350356 | 126810 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 6.5 | CCCCN(CC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm049737f | |||
| 18691318 | 103935 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 423 | 5 | 0 | 3 | 6.8 | CCN(c1nc(C)cc(-c2ccccc2C)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL268043 | 103935 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 423 | 5 | 0 | 3 | 6.8 | CCN(c1nc(C)cc(-c2ccccc2C)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 135958362 | 64940 | 0 | None | -2 | 2 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 482 | 2 | 4 | 7 | 3.7 | N[C@@H]1CCCC[C@H]1NC(=O)c1c2c(c3c(O)c4ccccc4c4ncnc1c34)=N[C@H]1CCCC[C@@H]1N2 | 10.1016/s0960-894x(99)00075-x | |||
| CHEMBL168162 | 64940 | 0 | None | -2 | 2 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 482 | 2 | 4 | 7 | 3.7 | N[C@@H]1CCCC[C@H]1NC(=O)c1c2c(c3c(O)c4ccccc4c4ncnc1c34)=N[C@H]1CCCC[C@@H]1N2 | 10.1016/s0960-894x(99)00075-x | |||
| 44392788 | 130529 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 387 | 6 | 0 | 4 | 5.8 | CCCN(c1ccccc1)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL362224 | 130529 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 387 | 6 | 0 | 4 | 5.8 | CCCN(c1ccccc1)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 44341612 | 117451 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 446 | 10 | 0 | 4 | 7.5 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(CCC)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL325960 | 117451 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 446 | 10 | 0 | 4 | 7.5 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(CCC)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| 20779996 | 13362 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 450 | 5 | 0 | 5 | 5.9 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(C)Cc4ccco4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083101 | 13362 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 450 | 5 | 0 | 5 | 5.9 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(C)Cc4ccco4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 122193721 | 130740 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 402 | 3 | 1 | 4 | 4.4 | Cc1cc(N(C)C)c2c(n1)N(c1ccc(C(C)C)cc1Br)CC(=O)N2 | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628741 | 130740 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 402 | 3 | 1 | 4 | 4.4 | Cc1cc(N(C)C)c2c(n1)N(c1ccc(C(C)C)cc1Br)CC(=O)N2 | 10.1016/j.bmcl.2015.10.010 | |||
| 10204577 | 128805 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 454 | 5 | 1 | 5 | 6.7 | CCc1nccn1Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL359494 | 128805 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 454 | 5 | 1 | 5 | 6.7 | CCc1nccn1Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 44389071 | 70128 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 426 | 4 | 1 | 5 | 6.1 | FC(F)(F)c1nc(Nc2c(Cl)cc(Cl)cc2Cl)sc1Cn1ccnc1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL179480 | 70128 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 426 | 4 | 1 | 5 | 6.1 | FC(F)(F)c1nc(Nc2c(Cl)cc(Cl)cc2Cl)sc1Cn1ccnc1 | 10.1016/j.bmcl.2004.10.055 | |||
| 11141163 | 170384 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 301 | 4 | 2 | 3 | 3.9 | CC(=O)/C(=N\c1ccc(Cl)cc1)NNc1ccccc1C | 10.1021/jm025512y | |||
| CHEMBL420361 | 170384 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 301 | 4 | 2 | 3 | 3.9 | CC(=O)/C(=N\c1ccc(Cl)cc1)NNc1ccccc1C | 10.1021/jm025512y | |||
| 10663467 | 64283 | 1 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 319 | 3 | 0 | 3 | 4.2 | CCc1ccc(N(C)c2nc(C)cc(C)n2)c(Br)c1 | 10.1021/jm980222w | |||
| CHEMBL166102 | 64283 | 1 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 319 | 3 | 0 | 3 | 4.2 | CCc1ccc(N(C)c2nc(C)cc(C)n2)c(Br)c1 | 10.1021/jm980222w | |||
| 44379486 | 126810 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 6.5 | CCCCN(CC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL350356 | 126810 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 6.5 | CCCCN(CC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 44392644 | 129799 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 355 | 6 | 0 | 5 | 4.5 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(F)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL360905 | 129799 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 355 | 6 | 0 | 5 | 4.5 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(F)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 44306220 | 107646 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 381 | 9 | 0 | 5 | 4.9 | CCCN(c1ncc(C)c(-c2ccc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL293627 | 107646 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 381 | 9 | 0 | 5 | 4.9 | CCCN(c1ncc(C)c(-c2ccc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| 46881397 | 14275 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 432 | 6 | 0 | 4 | 5.2 | C=CCN(CC=C)C(=O)c1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1087167 | 14275 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 432 | 6 | 0 | 4 | 5.2 | C=CCN(CC=C)C(=O)c1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| 10111096 | 70759 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 391 | 8 | 0 | 3 | 6.2 | CCCN(CC1CC1)c1nc(CC)c(-c2ccc(Cl)cc2Cl)nc1CC | 10.1021/jm200365y | |||
| CHEMBL1807025 | 70759 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 391 | 8 | 0 | 3 | 6.2 | CCCN(CC1CC1)c1nc(CC)c(-c2ccc(Cl)cc2Cl)nc1CC | 10.1021/jm200365y | |||
| 10694719 | 65829 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 446 | 6 | 1 | 8 | 3.8 | CCC(Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br)C(=O)OC | 10.1021/jm980224g | |||
| CHEMBL169460 | 65829 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 446 | 6 | 1 | 8 | 3.8 | CCC(Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br)C(=O)OC | 10.1021/jm980224g | |||
| 11568262 | 77060 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 434 | 4 | 0 | 4 | 6.1 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3C(F)(F)F)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL194295 | 77060 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 434 | 4 | 0 | 4 | 6.1 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3C(F)(F)F)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 11713460 | 142350 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 414 | 4 | 0 | 4 | 6.1 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1CC1CCC1 | 10.1021/jm049085v | |||
| CHEMBL372905 | 142350 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 414 | 4 | 0 | 4 | 6.1 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1CC1CCC1 | 10.1021/jm049085v | |||
| 44462060 | 212684 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 385 | 9 | 0 | 5 | 4.9 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)n(CCC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL83970 | 212684 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 385 | 9 | 0 | 5 | 4.9 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)n(CCC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 11441545 | 74353 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 420 | 5 | 0 | 6 | 4.1 | CCCC(OC)N1CCn2c(=O)n(-c3ccc(C(F)(F)F)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL190037 | 74353 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 420 | 5 | 0 | 6 | 4.1 | CCCC(OC)N1CCn2c(=O)n(-c3ccc(C(F)(F)F)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 21916311 | 14072 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 500 | 5 | 0 | 4 | 6.9 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCCC4Cc4ccccc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1086061 | 14072 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 500 | 5 | 0 | 4 | 6.9 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCCC4Cc4ccccc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 11188091 | 175202 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 377 | 7 | 0 | 4 | 5.7 | CCCC(CCC)N1CCc2cn(-c3cccc(OC)c3)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL434910 | 175202 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 377 | 7 | 0 | 4 | 5.7 | CCCC(CCC)N1CCc2cn(-c3cccc(OC)c3)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 44392777 | 72258 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 401 | 10 | 1 | 7 | 3.5 | CCCN(CC1CC1)c1cc(C(O)c2c(OC)cc(OC)cc2OC)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL183037 | 72258 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 401 | 10 | 1 | 7 | 3.5 | CCCN(CC1CC1)c1cc(C(O)c2c(OC)cc(OC)cc2OC)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| 44392750 | 132296 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 415 | 10 | 1 | 7 | 3.7 | CCCN(CC1CC1)c1cc(C(C)(O)c2c(OC)cc(OC)cc2OC)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL364640 | 132296 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 415 | 10 | 1 | 7 | 3.7 | CCCN(CC1CC1)c1cc(C(C)(O)c2c(OC)cc(OC)cc2OC)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| 46890889 | 13369 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 475 | 6 | 0 | 5 | 5.8 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(C)CCc4cccnc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083119 | 13369 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 475 | 6 | 0 | 5 | 5.8 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(C)CCc4cccnc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 46890950 | 14071 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 556 | 8 | 0 | 4 | 7.7 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCc4ccccc4)CCC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1086059 | 14071 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 556 | 8 | 0 | 4 | 7.7 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCc4ccccc4)CCC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 11223591 | 75387 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 409 | 7 | 0 | 3 | 6.7 | CCCC(CCC)N1CCc2cn(Cc3ccc(Cl)cc3C)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL191780 | 75387 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 409 | 7 | 0 | 3 | 6.7 | CCCC(CCC)N1CCc2cn(Cc3ccc(Cl)cc3C)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 20780284 | 70277 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 380 | 8 | 0 | 4 | 5.1 | CCCN(Cc1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C)CC1CC1 | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL179985 | 70277 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 380 | 8 | 0 | 4 | 5.1 | CCCN(Cc1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C)CC1CC1 | 10.1016/j.bmcl.2005.05.117 | |||
| 44389113 | 71386 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 474 | 8 | 1 | 5 | 6.2 | CCN(CCN(C)C)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181732 | 71386 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 474 | 8 | 1 | 5 | 6.2 | CCN(CCN(C)C)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 44307893 | 210254 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 335 | 3 | 1 | 5 | 4.1 | CCNc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL66052 | 210254 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 335 | 3 | 1 | 5 | 4.1 | CCNc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 10501205 | 65860 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 400 | 3 | 0 | 6 | 4.0 | Cc1nc(N2CCCC2)c2nnn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980224g | |||
| CHEMBL169629 | 65860 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 400 | 3 | 0 | 6 | 4.0 | Cc1nc(N2CCCC2)c2nnn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980224g | |||
| 10741433 | 127146 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 432 | 6 | 1 | 7 | 4.2 | COCC(C)(C)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL353238 | 127146 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 432 | 6 | 1 | 7 | 4.2 | COCC(C)(C)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 11078292 | 174989 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 339 | 4 | 2 | 3 | 4.1 | CC(=O)/C(=N\c1cccc(F)c1)NNc1ccccc1C(F)(F)F | 10.1021/jm025512y | |||
| CHEMBL433505 | 174989 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 339 | 4 | 2 | 3 | 4.1 | CC(=O)/C(=N\c1cccc(F)c1)NNc1ccccc1C(F)(F)F | 10.1021/jm025512y | |||
| 11474959 | 82073 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 396 | 5 | 1 | 5 | 4.9 | COc1ccc(S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL203744 | 82073 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 396 | 5 | 1 | 5 | 4.9 | COc1ccc(S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2005.10.097 | |||
| 10028059 | 109663 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 6.9 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Br | 10.1021/jm9900117 | |||
| CHEMBL305900 | 109663 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 6.9 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Br | 10.1021/jm9900117 | |||
| CHEMBL2372950 | 217100 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCC)NC(=O)[C@H](CCCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(C)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](N)Cc2ccccc2)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N1)C(=O)CN[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm034180+ | |||||
| 9843598 | 74550 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 394 | 7 | 0 | 6 | 4.3 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(OC)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL190845 | 74550 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 394 | 7 | 0 | 6 | 4.3 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(OC)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 10835052 | 64864 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 403 | 7 | 0 | 3 | 6.7 | CCC(CC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL167407 | 64864 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 403 | 7 | 0 | 3 | 6.7 | CCC(CC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL263451 | 217351 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](N)Cc2ccccc2)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N1)[C@@H](C)CC)C(N)=O | 10.1021/jm990590f | |||||
| 10344587 | 174623 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 467 | 8 | 0 | 7 | 3.9 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(Br)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL1762817 | 174623 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 467 | 8 | 0 | 7 | 3.9 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(Br)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2013.02.009 | |||
| CHEMBL430892 | 174623 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 467 | 8 | 0 | 7 | 3.9 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(Br)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2013.02.009 | |||
| 10344587 | 174623 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 467 | 8 | 0 | 7 | 3.9 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(Br)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL1762817 | 174623 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 467 | 8 | 0 | 7 | 3.9 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(Br)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2012.08.112 | |||
| CHEMBL430892 | 174623 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 467 | 8 | 0 | 7 | 3.9 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(Br)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2012.08.112 | |||
| 44341832 | 16190 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL111665 | 16190 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| 44341832 | 16190 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL111665 | 16190 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 44307738 | 107590 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCN(CCC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/j.bmc.2017.10.012 | |||
| CHEMBL293228 | 107590 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCN(CCC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/j.bmc.2017.10.012 | |||
| 44307491 | 109069 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCCN(CC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/j.bmc.2017.10.012 | |||
| CHEMBL303380 | 109069 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCCN(CC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/j.bmc.2017.10.012 | |||
| 176157 | 9515 | 28 | None | 9 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1016/j.bmcl.2005.05.117 | |||
| 3512 | 9515 | 28 | None | 9 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL45281 | 9515 | 28 | None | 9 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1016/j.bmcl.2005.05.117 | |||
| 44307738 | 107590 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCN(CCC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL293228 | 107590 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCN(CCC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 44307491 | 109069 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCCN(CC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL303380 | 109069 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCCN(CC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 3533 | 7989 | 24 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 482 | 8 | 0 | 4 | 7.5 | C#CCN([C@H](c1ccc(c(c1)F)C)CC1CC1)c1sc(c(n1)c1cc(C)c(cc1Cl)OC)C | 10.1016/j.bmcl.2008.07.063 | |||
| 5282340 | 7989 | 24 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 482 | 8 | 0 | 4 | 7.5 | C#CCN([C@H](c1ccc(c(c1)F)C)CC1CC1)c1sc(c(n1)c1cc(C)c(cc1Cl)OC)C | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL291657 | 7989 | 24 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 482 | 8 | 0 | 4 | 7.5 | C#CCN([C@H](c1ccc(c(c1)F)C)CC1CC1)c1sc(c(n1)c1cc(C)c(cc1Cl)OC)C | 10.1016/j.bmcl.2008.07.063 | |||
| 42618174 | 200113 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 385 | 8 | 1 | 8 | 2.8 | COCC(COC)Nc1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL524616 | 200113 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 385 | 8 | 1 | 8 | 2.8 | COCC(COC)Nc1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | 10.1016/j.bmcl.2008.07.063 | |||
| 44587375 | 200179 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 393 | 9 | 0 | 6 | 4.8 | CCCN(CCC)c1c(C)nc(-c2c(OC)cc(Cl)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL525716 | 200179 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 393 | 9 | 0 | 6 | 4.8 | CCCN(CCC)c1c(C)nc(-c2c(OC)cc(Cl)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| 10028059 | 109663 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 6.9 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Br | 10.1021/jm960149e | |||
| CHEMBL305900 | 109663 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 6.9 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Br | 10.1021/jm960149e | |||
| 176157 | 9515 | 28 | None | 9 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1021/jm049339c | |||
| 3512 | 9515 | 28 | None | 9 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1021/jm049339c | |||
| CHEMBL45281 | 9515 | 28 | None | 9 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1021/jm049339c | |||
| 44341581 | 16763 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 7.1 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(CC)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL114861 | 16763 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 7.1 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(CC)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| 44341877 | 117242 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 412 | 8 | 0 | 4 | 6.6 | CCCCN(CCCC)c1cc(C)nc2c(-c3c(C)cc(C)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL324728 | 117242 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 412 | 8 | 0 | 4 | 6.6 | CCCCN(CCCC)c1cc(C)nc2c(-c3c(C)cc(C)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 127033261 | 145252 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 3992 | 134 | 55 | 49 | -7.3 | CCCCCCCCCCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3774713 | 145252 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 3992 | 134 | 55 | 49 | -7.3 | CCCCCCCCCCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.5b00926 | |||
| 10739593 | 65769 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 397 | 8 | 0 | 6 | 5.6 | CCCCN(CC)c1cc(C)nc2c1nnn2-c1ccc(C(C)C)cc1SC | 10.1021/jm980224g | |||
| CHEMBL169010 | 65769 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 397 | 8 | 0 | 6 | 5.6 | CCCCN(CC)c1cc(C)nc2c1nnn2-c1ccc(C(C)C)cc1SC | 10.1021/jm980224g | |||
| 44342074 | 16712 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 372 | 6 | 0 | 2 | 6.8 | CCCN(CC1CC1)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL114596 | 16712 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 372 | 6 | 0 | 2 | 6.8 | CCCN(CC1CC1)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 22249054 | 70781 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 397 | 8 | 1 | 5 | 5.3 | CCc1nc(NC(CC)CC)c(OC)nc1-c1ccc(OC)cc1C(F)(F)F | 10.1021/jm200365y | |||
| CHEMBL1807051 | 70781 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 397 | 8 | 1 | 5 | 5.3 | CCc1nc(NC(CC)CC)c(OC)nc1-c1ccc(OC)cc1C(F)(F)F | 10.1021/jm200365y | |||
| 11291949 | 134287 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL366155 | 134287 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 44375151 | 63432 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1nc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(00)00071-8 | |||
| CHEMBL164206 | 63432 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1nc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(00)00071-8 | |||
| 9801874 | 109749 | 1 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 412 | 7 | 1 | 4 | 6.4 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C | 10.1021/jm960149e | |||
| CHEMBL306482 | 109749 | 1 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 412 | 7 | 1 | 4 | 6.4 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C | 10.1021/jm960149e | |||
| 9801874 | 109749 | 1 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 412 | 7 | 1 | 4 | 6.4 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C | 10.1021/jm9900117 | |||
| CHEMBL306482 | 109749 | 1 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 412 | 7 | 1 | 4 | 6.4 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C | 10.1021/jm9900117 | |||
| 11247393 | 73587 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 428 | 6 | 0 | 6 | 5.1 | CCN(Cc1ccc(C)cc1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL186033 | 73587 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 428 | 6 | 0 | 6 | 5.1 | CCN(Cc1ccc(C)cc1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 44347137 | 21707 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 394 | 8 | 0 | 6 | 4.7 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL120823 | 21707 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 394 | 8 | 0 | 6 | 4.7 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 44347202 | 120291 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 7 | 0 | 5 | 4.6 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(OC)cc3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL332101 | 120291 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 7 | 0 | 5 | 4.6 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(OC)cc3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 9950788 | 117293 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 360 | 6 | 0 | 2 | 6.8 | CCCCN(CC)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL325047 | 117293 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 360 | 6 | 0 | 2 | 6.8 | CCCCN(CC)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 10095518 | 11151 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 454 | 6 | 0 | 5 | 6.4 | CCN(c1nc(C)cc(-c2ccccc2[N+](=O)[O-])n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL10125 | 11151 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 454 | 6 | 0 | 5 | 6.4 | CCN(c1nc(C)cc(-c2ccccc2[N+](=O)[O-])n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 10027220 | 73639 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 458 | 7 | 1 | 4 | 6.0 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL186252 | 73639 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 458 | 7 | 1 | 4 | 6.0 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| 122193720 | 130739 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 508 | 6 | 0 | 4 | 5.7 | CCCCN(CC)c1cc(C)nc2c1N(C)C(=O)CN2c1ccc(Br)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628740 | 130739 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 508 | 6 | 0 | 4 | 5.7 | CCCCN(CC)c1cc(C)nc2c1N(C)C(=O)CN2c1ccc(Br)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| 11430299 | 73506 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 428 | 6 | 0 | 6 | 5.1 | CCN(Cc1cccc(C)c1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL185705 | 73506 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 428 | 6 | 0 | 6 | 5.1 | CCN(Cc1cccc(C)c1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 11224120 | 130079 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 428 | 6 | 0 | 6 | 5.1 | CCN(Cc1ccccc1C)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL361509 | 130079 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 428 | 6 | 0 | 6 | 5.1 | CCN(Cc1ccccc1C)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 44341874 | 16690 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 412 | 6 | 0 | 2 | 7.5 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)ccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL114422 | 16690 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 412 | 6 | 0 | 2 | 7.5 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)ccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 177990 | 7214 | 23 | None | 1 | 2 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1016/s0960-894x(00)00071-8 | |||
| 3489 | 7214 | 23 | None | 1 | 2 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1016/s0960-894x(00)00071-8 | |||
| CHEMBL296641 | 7214 | 23 | None | 1 | 2 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1016/s0960-894x(00)00071-8 | |||
| 15490822 | 105042 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 481 | 5 | 0 | 4 | 7.1 | CCN(c1nc(C)cc(-c2ccccc2C(F)(F)F)n1)c1ccc(SC)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL274578 | 105042 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 481 | 5 | 0 | 4 | 7.1 | CCN(c1nc(C)cc(-c2ccccc2C(F)(F)F)n1)c1ccc(SC)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 90231885 | 130729 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 444 | 7 | 1 | 4 | 5.4 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Br)cc1CC | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628729 | 130729 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 444 | 7 | 1 | 4 | 5.4 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Br)cc1CC | 10.1016/j.bmcl.2015.10.010 | |||
| 90231897 | 130730 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 450 | 6 | 1 | 4 | 5.5 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628730 | 130730 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 450 | 6 | 1 | 4 | 5.5 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| 22249128 | 70789 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 399 | 9 | 1 | 5 | 5.6 | CCc1nc(-c2ccc(OC(F)F)cc2Cl)c(OC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1807059 | 70789 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 399 | 9 | 1 | 5 | 5.6 | CCc1nc(-c2ccc(OC(F)F)cc2Cl)c(OC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 10787254 | 211664 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 400 | 7 | 1 | 4 | 6.4 | CCCN(CCC)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C | 10.1021/jm960149e | |||
| CHEMBL75859 | 211664 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 400 | 7 | 1 | 4 | 6.4 | CCCN(CCC)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C | 10.1021/jm960149e | |||
| 10787254 | 211664 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 400 | 7 | 1 | 4 | 6.4 | CCCN(CCC)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C | 10.1021/jm9900117 | |||
| CHEMBL75859 | 211664 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 400 | 7 | 1 | 4 | 6.4 | CCCN(CCC)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C | 10.1021/jm9900117 | |||
| 11465828 | 73536 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 482 | 6 | 0 | 6 | 6.1 | CCN(Cc1ccc(Cl)c(Cl)c1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL185858 | 73536 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 482 | 6 | 0 | 6 | 6.1 | CCN(Cc1ccc(Cl)c(Cl)c1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 177990 | 7214 | 23 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1021/jm049085v | |||
| 3489 | 7214 | 23 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1021/jm049085v | |||
| CHEMBL296641 | 7214 | 23 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1021/jm049085v | |||
| 44347046 | 121323 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 377 | 6 | 0 | 3 | 6.5 | CCCCN(CC)c1cc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL333713 | 121323 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 377 | 6 | 0 | 3 | 6.5 | CCCCN(CC)c1cc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2004.05.056 | |||
| 44347046 | 121323 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 377 | 6 | 0 | 3 | 6.5 | CCCCN(CC)c1cc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL333713 | 121323 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 377 | 6 | 0 | 3 | 6.5 | CCCCN(CC)c1cc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2004.05.019 | |||
| 3520 | 10041 | 54 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2015.10.010 | |||
| 9821250 | 10041 | 54 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL309138 | 10041 | 54 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2015.10.010 | |||
| 11773421 | 72862 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCCN(CC)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL183845 | 72862 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCCN(CC)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 11326815 | 74335 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 392 | 7 | 0 | 6 | 4.4 | CCCN(CC1CC1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL189821 | 74335 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 392 | 7 | 0 | 6 | 4.4 | CCCN(CC1CC1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 3495 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm960861b | |||
| 5311055 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm960861b | |||
| CHEMBL9946 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm960861b | |||
| 176157 | 9515 | 28 | None | 9 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1016/j.bmcl.2004.05.072 | |||
| 3512 | 9515 | 28 | None | 9 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL45281 | 9515 | 28 | None | 9 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1016/j.bmcl.2004.05.072 | |||
| 3495 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/s0960-894x(99)00132-8 | |||
| 5311055 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL9946 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/s0960-894x(99)00132-8 | |||
| 3495 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2005.05.117 | |||
| 5311055 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL9946 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2005.05.117 | |||
| 90231888 | 130731 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 450 | 6 | 1 | 4 | 5.5 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Br)cc1Cl | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628731 | 130731 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 450 | 6 | 1 | 4 | 5.5 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Br)cc1Cl | 10.1016/j.bmcl.2015.10.010 | |||
| 3495 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/s0960-894x(02)00358-x | |||
| 5311055 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL9946 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/s0960-894x(02)00358-x | |||
| 3495 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2007.12.050 | |||
| 5311055 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL9946 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2007.12.050 | |||
| 11306178 | 85101 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 444 | 10 | 0 | 5 | 6.4 | CCCC[C@@H](c1ccc(F)cc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 11306179 | 85101 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 444 | 10 | 0 | 5 | 6.4 | CCCC[C@@H](c1ccc(F)cc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL2094063 | 85101 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 444 | 10 | 0 | 5 | 6.4 | CCCC[C@@H](c1ccc(F)cc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL2109725 | 85101 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 444 | 10 | 0 | 5 | 6.4 | CCCC[C@@H](c1ccc(F)cc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 3495 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm990590f | |||
| 5311055 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm990590f | |||
| CHEMBL9946 | 7958 | 28 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1021/jm990590f | |||
| 10788803 | 64351 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 430 | 7 | 1 | 6 | 5.4 | CCCC(CC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL166669 | 64351 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 430 | 7 | 1 | 6 | 5.4 | CCCC(CC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44341879 | 16658 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 398 | 8 | 0 | 4 | 6.3 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(C)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL114273 | 16658 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 398 | 8 | 0 | 4 | 6.3 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(C)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 44290322 | 107947 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 382 | 8 | 0 | 6 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1021/jm990590f | |||
| CHEMBL295563 | 107947 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 382 | 8 | 0 | 6 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1021/jm990590f | |||
| 10646985 | 64601 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 444 | 8 | 0 | 5 | 6.4 | CCCCC(CC)Oc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL167017 | 64601 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 444 | 8 | 0 | 5 | 6.4 | CCCCC(CC)Oc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 11282181 | 74125 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 442 | 8 | 0 | 6 | 5.6 | CCCCN(Cc1ccccc1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL188566 | 74125 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 442 | 8 | 0 | 6 | 5.6 | CCCCN(Cc1ccccc1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 9802053 | 130972 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 416 | 6 | 0 | 4 | 6.4 | CCCC(CCC)N1CCc2nn(-c3ccc(Cl)cc3Cl)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL363414 | 130972 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 416 | 6 | 0 | 4 | 6.4 | CCCC(CCC)N1CCc2nn(-c3ccc(Cl)cc3Cl)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 176157 | 9515 | 28 | None | 9 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 3512 | 9515 | 28 | None | 9 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL45281 | 9515 | 28 | None | 9 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 11326483 | 74553 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 380 | 5 | 0 | 6 | 3.8 | CCC(CC)N1CCn2c(=O)n(-c3ccc(OC)cc3C)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL190881 | 74553 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 380 | 5 | 0 | 6 | 3.8 | CCC(CC)N1CCn2c(=O)n(-c3ccc(OC)cc3C)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 21916279 | 172582 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 414 | 7 | 0 | 4 | 6.1 | CCCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL424812 | 172582 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 414 | 7 | 0 | 4 | 6.1 | CCCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| 10810752 | 64273 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 396 | 7 | 0 | 6 | 4.3 | CCN(CC)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C(F)(F)F)n1 | 10.1021/jm980222w | |||
| CHEMBL165991 | 64273 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 396 | 7 | 0 | 6 | 4.3 | CCN(CC)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C(F)(F)F)n1 | 10.1021/jm980222w | |||
| 10710543 | 65280 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 316 | 5 | 0 | 5 | 4.0 | CCN(c1nc(C)cc(C)n1)c1ccc(N(C)C)cc1SC | 10.1021/jm980222w | |||
| CHEMBL168360 | 65280 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 316 | 5 | 0 | 5 | 4.0 | CCN(c1nc(C)cc(C)n1)c1ccc(N(C)C)cc1SC | 10.1021/jm980222w | |||
| 176157 | 9515 | 28 | None | 9 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1016/j.bmcl.2005.05.117 | |||
| 3512 | 9515 | 28 | None | 9 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL45281 | 9515 | 28 | None | 9 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1016/j.bmcl.2005.05.117 | |||
| 44307747 | 210364 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCN(CCC)c1nc(C)nc2c(-c3c(Cl)cccc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL66831 | 210364 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCN(CCC)c1nc(C)nc2c(-c3c(Cl)cccc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 20780178 | 100574 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 435 | 6 | 0 | 5 | 5.9 | CCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12)CC1CCC1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL247558 | 100574 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 435 | 6 | 0 | 5 | 5.9 | CCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12)CC1CCC1 | 10.1016/j.bmcl.2007.01.008 | |||
| 11153216 | 132612 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)cnn12 | 10.1021/jm040058e | |||
| CHEMBL364828 | 132612 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)cnn12 | 10.1021/jm040058e | |||
| 10504455 | 65498 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 466 | 6 | 0 | 6 | 4.7 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1ccc(Br)cc1Br | 10.1021/jm980224g | |||
| CHEMBL168531 | 65498 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 466 | 6 | 0 | 6 | 4.7 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1ccc(Br)cc1Br | 10.1021/jm980224g | |||
| 15490823 | 105225 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 513 | 5 | 0 | 5 | 5.8 | CCN(c1nc(C)cc(-c2ccccc2C(F)(F)F)n1)c1ccc(S(C)(=O)=O)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL275738 | 105225 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 513 | 5 | 0 | 5 | 5.8 | CCN(c1nc(C)cc(-c2ccccc2C(F)(F)F)n1)c1ccc(S(C)(=O)=O)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 10500190 | 65561 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 383 | 8 | 0 | 7 | 3.1 | COCCN(CCOC)c1nc(C)nc2c1ncn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL168788 | 65561 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 383 | 8 | 0 | 7 | 3.1 | COCCN(CCOC)c1nc(C)nc2c1ncn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| 10736859 | 127109 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 354 | 6 | 0 | 7 | 2.9 | CCN(CCOC)c1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL352916 | 127109 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 354 | 6 | 0 | 7 | 2.9 | CCN(CCOC)c1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| 136216702 | 85396 | 0 | None | -2 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 428 | 3 | 4 | 7 | 2.7 | NCCNC(=O)c1c2c(c3c4c(ncnc14)-c1ccccc1C3=O)N[C@H]1CCCC[C@@H]1N2 | 10.1016/s0960-894x(99)00075-x | |||
| CHEMBL2112326 | 85396 | 0 | None | -2 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 428 | 3 | 4 | 7 | 2.7 | NCCNC(=O)c1c2c(c3c4c(ncnc14)-c1ccccc1C3=O)N[C@H]1CCCC[C@@H]1N2 | 10.1016/s0960-894x(99)00075-x | |||
| 11222924 | 74375 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 386 | 5 | 0 | 6 | 3.7 | CCCC(OC)N1CCn2c(=O)n(-c3ccc(Cl)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL190262 | 74375 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 386 | 5 | 0 | 6 | 3.7 | CCCC(OC)N1CCn2c(=O)n(-c3ccc(Cl)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 44392772 | 129757 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 351 | 7 | 0 | 4 | 4.6 | CCCN(CC1CC1)c1cc(C(=O)c2c(C)cc(C)cc2C)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL360845 | 129757 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 351 | 7 | 0 | 4 | 4.6 | CCCN(CC1CC1)c1cc(C(=O)c2c(C)cc(C)cc2C)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| 44305974 | 109622 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 425 | 9 | 0 | 7 | 5.1 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C1(c2ccsc2)CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL305583 | 109622 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 425 | 9 | 0 | 7 | 5.1 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C1(c2ccsc2)CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| 10761294 | 127173 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 364 | 2 | 0 | 5 | 4.1 | Cc1cc(C)c(-n2c(C)c(C)c3c(N4CCOCC4)nc(C)nc32)c(C)c1 | 10.1021/jm980224g | |||
| CHEMBL353425 | 127173 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 364 | 2 | 0 | 5 | 4.1 | Cc1cc(C)c(-n2c(C)c(C)c3c(N4CCOCC4)nc(C)nc32)c(C)c1 | 10.1021/jm980224g | |||
| 9980256 | 101192 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 432 | 7 | 1 | 7 | 4.7 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OC(C)=O | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL251034 | 101192 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 432 | 7 | 1 | 7 | 4.7 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OC(C)=O | 10.1016/j.bmcl.2007.09.008 | |||
| 10551475 | 127556 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 448 | 9 | 0 | 8 | 3.2 | COCCN(CCOC)c1ncnc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL355394 | 127556 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 448 | 9 | 0 | 8 | 3.2 | COCCN(CCOC)c1ncnc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44317962 | 212406 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 462 | 7 | 1 | 3 | 6.5 | O=C(CCc1ccncc1)C(Nc1ccc(Cl)cc1Cl)c1ccccc1Br | 10.1021/jm049974i | |||
| CHEMBL81726 | 212406 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 462 | 7 | 1 | 3 | 6.5 | O=C(CCc1ccncc1)C(Nc1ccc(Cl)cc1Cl)c1ccccc1Br | 10.1021/jm049974i | |||
| 135884427 | 63949 | 0 | None | -3 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 374 | 3 | 4 | 7 | 1.1 | NCCNC(=O)c1c2c(c3c(O)c4ccccc4c4ncnc1c34)=NCCN2 | 10.1016/s0960-894x(99)00075-x | |||
| CHEMBL164829 | 63949 | 0 | None | -3 | 2 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 374 | 3 | 4 | 7 | 1.1 | NCCNC(=O)c1c2c(c3c(O)c4ccccc4c4ncnc1c34)=NCCN2 | 10.1016/s0960-894x(99)00075-x | |||
| 44318122 | 212607 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 371 | 8 | 0 | 5 | 4.5 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)n(CC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL83385 | 212607 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 371 | 8 | 0 | 5 | 4.5 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)n(CC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 44352382 | 123506 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 475 | 8 | 1 | 4 | 6.9 | CCCN(Cc1sc(Nc2c(C)cc(C)cc2Br)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL337409 | 123506 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 475 | 8 | 1 | 4 | 6.9 | CCCN(Cc1sc(Nc2c(C)cc(C)cc2Br)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 21916208 | 74113 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 428 | 8 | 0 | 4 | 6.4 | CCCN(Cc1c(CC)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL188523 | 74113 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 428 | 8 | 0 | 4 | 6.4 | CCCN(Cc1c(CC)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| 10717814 | 127125 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 436 | 10 | 0 | 10 | 2.3 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1c(Cl)cc(OC)cc1OC | 10.1021/jm980224g | |||
| CHEMBL353050 | 127125 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 436 | 10 | 0 | 10 | 2.3 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1c(Cl)cc(OC)cc1OC | 10.1021/jm980224g | |||
| 10254503 | 16504 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 6.9 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Br)cc2Cl)c1Cl | 10.1016/s0960-894x(00)00661-2 | |||
| CHEMBL113333 | 16504 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 6.9 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Br)cc2Cl)c1Cl | 10.1016/s0960-894x(00)00661-2 | |||
| 21916260 | 13363 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 502 | 8 | 0 | 4 | 7.2 | CCCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083102 | 13363 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 502 | 8 | 0 | 4 | 7.2 | CCCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 21916302 | 14436 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 448 | 7 | 0 | 4 | 6.4 | CCCN(Cc1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C)CC1CCC1 | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1088478 | 14436 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 448 | 7 | 0 | 4 | 6.4 | CCCN(Cc1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C)CC1CCC1 | 10.1016/j.bmcl.2010.01.127 | |||
| 44446720 | 101554 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 366 | 6 | 0 | 2 | 6.8 | CCCN(CCC)c1c(C)nc(-c2ccc(Cl)cc2C)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL253287 | 101554 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 366 | 6 | 0 | 2 | 6.8 | CCCN(CCC)c1c(C)nc(-c2ccc(Cl)cc2C)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 11393576 | 130572 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 337 | 6 | 0 | 5 | 4.3 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(C)nc3)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL362305 | 130572 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 337 | 6 | 0 | 5 | 4.3 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(C)nc3)c(C)nn12 | 10.1021/jm040058e | |||
| 10552046 | 127569 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 462 | 8 | 0 | 8 | 3.5 | COCC(COC)N(C)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL355494 | 127569 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 462 | 8 | 0 | 8 | 3.5 | COCC(COC)N(C)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 122193727 | 130745 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 476 | 7 | 0 | 4 | 5.6 | Cc1cc(N(C)C)c2c(n1)N(c1ccc(C(C)C)cc1Br)CC(=O)N2CCCCF | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628746 | 130745 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 476 | 7 | 0 | 4 | 5.6 | Cc1cc(N(C)C)c2c(n1)N(c1ccc(C(C)C)cc1Br)CC(=O)N2CCCCF | 10.1016/j.bmcl.2015.10.010 | |||
| 11795486 | 127191 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 403 | 6 | 1 | 6 | 4.1 | COCCNc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL353662 | 127191 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 403 | 6 | 1 | 6 | 4.1 | COCCNc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44315264 | 211869 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.5 | Cc1cc(C)c(Nc2nc(C)nc(N(C)CCc3ccccc3)n2)c(C)c1 | 10.1021/jm960148m | |||
| CHEMBL77527 | 211869 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.5 | Cc1cc(C)c(Nc2nc(C)nc(N(C)CCc3ccccc3)n2)c(C)c1 | 10.1021/jm960148m | |||
| 44315264 | 211869 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.5 | Cc1cc(C)c(Nc2nc(C)nc(N(C)CCc3ccccc3)n2)c(C)c1 | 10.1021/jm9900117 | |||
| CHEMBL77527 | 211869 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 361 | 6 | 1 | 5 | 4.5 | Cc1cc(C)c(Nc2nc(C)nc(N(C)CCc3ccccc3)n2)c(C)c1 | 10.1021/jm9900117 | |||
| 44443597 | 100766 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 348 | 6 | 1 | 5 | 5.2 | CCC(Nc1nc(C)c(Oc2cc(C)ccn2)nc1C)c1ccccc1 | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL248623 | 100766 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 348 | 6 | 1 | 5 | 5.2 | CCC(Nc1nc(C)c(Oc2cc(C)ccn2)nc1C)c1ccccc1 | 10.1016/j.bmcl.2007.09.008 | |||
| 44443649 | 161186 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 430 | 8 | 1 | 6 | 5.4 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OC1CC1 | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL398843 | 161186 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 430 | 8 | 1 | 6 | 5.4 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OC1CC1 | 10.1016/j.bmcl.2007.09.008 | |||
| 44446734 | 162386 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 431 | 8 | 0 | 4 | 6.1 | CCCN(CCN1CCCC1)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL404558 | 162386 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 431 | 8 | 0 | 4 | 6.1 | CCCN(CCN1CCCC1)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 1799074 | 210556 | 3 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 301 | 4 | 2 | 3 | 4.1 | CC(=O)/C(=N\Nc1ccccc1C)Nc1cccc(Cl)c1 | 10.1021/jm025512y | |||
| CHEMBL68118 | 210556 | 3 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 301 | 4 | 2 | 3 | 4.1 | CC(=O)/C(=N\Nc1ccccc1C)Nc1cccc(Cl)c1 | 10.1021/jm025512y | |||
| 44305524 | 210190 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 392 | 6 | 0 | 5 | 5.5 | CCCCN(OC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| CHEMBL65574 | 210190 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 392 | 6 | 0 | 5 | 5.5 | CCCCN(OC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| 11795560 | 64462 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 404 | 7 | 0 | 4 | 5.7 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL166890 | 64462 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 404 | 7 | 0 | 4 | 5.7 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 10741540 | 64902 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 434 | 9 | 0 | 5 | 5.3 | CCN(CCOC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL167737 | 64902 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 434 | 9 | 0 | 5 | 5.3 | CCN(CCOC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 10549990 | 174849 | 0 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 418 | 5 | 0 | 5 | 4.7 | CCN(c1nc(C)cc(N2CCOCC2)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980222w | |||
| CHEMBL432496 | 174849 | 0 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 418 | 5 | 0 | 5 | 4.7 | CCN(c1nc(C)cc(N2CCOCC2)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980222w | |||
| 10766371 | 66136 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 459 | 11 | 0 | 7 | 5.8 | CCCCc1nc2c(N(CC)CCCC)nc(C)nc2n1-c1c(Cl)cc(OC)cc1OC | 10.1021/jm980224g | |||
| CHEMBL170791 | 66136 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 459 | 11 | 0 | 7 | 5.8 | CCCCc1nc2c(N(CC)CCCC)nc(C)nc2n1-c1c(Cl)cc(OC)cc1OC | 10.1021/jm980224g | |||
| 10549990 | 174849 | 0 | None | 1 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 418 | 5 | 0 | 5 | 4.7 | CCN(c1nc(C)cc(N2CCOCC2)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980223o | |||
| CHEMBL432496 | 174849 | 0 | None | 1 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 418 | 5 | 0 | 5 | 4.7 | CCN(c1nc(C)cc(N2CCOCC2)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980223o | |||
| 10048452 | 100804 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 432 | 8 | 1 | 6 | 5.5 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2cc(C)cc(C)n2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL248785 | 100804 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 432 | 8 | 1 | 6 | 5.5 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2cc(C)cc(C)n2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| 9980267 | 101218 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 432 | 8 | 1 | 6 | 5.6 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OC(C)C | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL251200 | 101218 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 432 | 8 | 1 | 6 | 5.6 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OC(C)C | 10.1016/j.bmcl.2007.09.008 | |||
| 10133826 | 200114 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 371 | 9 | 0 | 5 | 5.0 | CCCN(CCC)c1c(CC)nc(-c2c(C)cc(C)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL524617 | 200114 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 371 | 9 | 0 | 5 | 5.0 | CCCN(CCC)c1c(CC)nc(-c2c(C)cc(C)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| 11178282 | 113201 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 408 | 10 | 0 | 6 | 5.3 | CCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL3085417 | 113201 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 408 | 10 | 0 | 6 | 5.3 | CCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL3139571 | 113201 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 408 | 10 | 0 | 6 | 5.3 | CCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 44337305 | 12079 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 358 | 7 | 0 | 4 | 4.8 | CCCN(c1nc(-c2ccc(Cl)cc2C)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL106675 | 12079 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 358 | 7 | 0 | 4 | 4.8 | CCCN(c1nc(-c2ccc(Cl)cc2C)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| 44392681 | 71299 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 339 | 6 | 1 | 4 | 4.9 | CCC(CC)Nc1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL181439 | 71299 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 339 | 6 | 1 | 4 | 4.9 | CCC(CC)Nc1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 20780282 | 70557 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 380 | 6 | 0 | 4 | 4.5 | CCCN(CC1CC1)C(=O)c1c(C)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL180178 | 70557 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 380 | 6 | 0 | 4 | 4.5 | CCCN(CC1CC1)C(=O)c1c(C)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 20780038 | 72383 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 436 | 7 | 0 | 4 | 5.3 | CCCN(CCC(F)(F)F)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL183348 | 72383 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 436 | 7 | 0 | 4 | 5.3 | CCCN(CCC(F)(F)F)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 20780036 | 72760 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 444 | 8 | 0 | 4 | 5.6 | CCCN(CCc1ccccc1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL183639 | 72760 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 444 | 8 | 0 | 4 | 5.6 | CCCN(CCc1ccccc1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 44306534 | 210247 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 371 | 8 | 0 | 6 | 4.3 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C1CCCC1 | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL65979 | 210247 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 371 | 8 | 0 | 6 | 4.3 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C1CCCC1 | 10.1016/j.bmcl.2004.02.053 | |||
| 44337502 | 12161 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 378 | 9 | 0 | 4 | 5.5 | C=CCn1nc(N(CCC)C(C2CC2)C2CC2)nc1-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL107091 | 12161 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 378 | 9 | 0 | 4 | 5.5 | C=CCn1nc(N(CCC)C(C2CC2)C2CC2)nc1-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(01)00657-6 | |||
| 44307772 | 176212 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 313 | 4 | 1 | 5 | 3.6 | CC(=O)/C(=N\Nc1ccccc1C#N)Oc1ccc(Cl)cc1 | 10.1021/jm025512y | |||
| CHEMBL442559 | 176212 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 313 | 4 | 1 | 5 | 3.6 | CC(=O)/C(=N\Nc1ccccc1C#N)Oc1ccc(Cl)cc1 | 10.1021/jm025512y | |||
| 10782556 | 66061 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 328 | 2 | 0 | 2 | 5.2 | Cc1ccc2ccn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| CHEMBL170487 | 66061 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 328 | 2 | 0 | 2 | 5.2 | Cc1ccc2ccn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| 44266524 | 169362 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 428 | 6 | 0 | 6 | 4.8 | CCN(c1nc(C)cc(-c2ccccn2)n1)c1c(Br)cc(OC)cc1OC | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL416882 | 169362 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 428 | 6 | 0 | 6 | 4.8 | CCN(c1nc(C)cc(-c2ccccn2)n1)c1c(Br)cc(OC)cc1OC | 10.1016/s0960-894x(99)00132-8 | |||
| 44443632 | 101256 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 404 | 7 | 1 | 6 | 4.8 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OC | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL251397 | 101256 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 404 | 7 | 1 | 6 | 4.8 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OC | 10.1016/j.bmcl.2007.09.008 | |||
| 18449326 | 70756 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 397 | 9 | 1 | 5 | 4.6 | CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1NC(COC)COC | 10.1021/jm200365y | |||
| CHEMBL1807022 | 70756 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 397 | 9 | 1 | 5 | 4.6 | CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1NC(COC)COC | 10.1021/jm200365y | |||
| 10892583 | 210209 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 321 | 4 | 2 | 3 | 3.9 | CC(=O)/C(=N\c1ccccc1)NNc1ccccc1C(F)(F)F | 10.1021/jm025512y | |||
| CHEMBL65721 | 210209 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 321 | 4 | 2 | 3 | 3.9 | CC(=O)/C(=N\c1ccccc1)NNc1ccccc1C(F)(F)F | 10.1021/jm025512y | |||
| 3623188 | 210750 | 1 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 301 | 4 | 2 | 3 | 3.9 | CC(=O)/C(=N\c1cccc(Cl)c1)NNc1ccc(C)cc1 | 10.1021/jm025512y | |||
| CHEMBL69431 | 210750 | 1 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 301 | 4 | 2 | 3 | 3.9 | CC(=O)/C(=N\c1cccc(Cl)c1)NNc1ccc(C)cc1 | 10.1021/jm025512y | |||
| 44266453 | 105043 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 428 | 6 | 0 | 6 | 4.8 | CCN(c1nc(C)cc(-c2cccnc2)n1)c1c(Br)cc(OC)cc1OC | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL274579 | 105043 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 428 | 6 | 0 | 6 | 4.8 | CCN(c1nc(C)cc(-c2cccnc2)n1)c1c(Br)cc(OC)cc1OC | 10.1016/s0960-894x(99)00132-8 | |||
| 12967650 | 26695 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 431 | 8 | 1 | 4 | 6.8 | CCCN(Cc1sc(Nc2c(C)cc(C)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL130265 | 26695 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 431 | 8 | 1 | 4 | 6.8 | CCCN(Cc1sc(Nc2c(C)cc(C)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 11246568 | 140390 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 399 | 6 | 0 | 6 | 4.3 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(Cl)cn3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL371348 | 140390 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 399 | 6 | 0 | 6 | 4.3 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(Cl)cn3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 15965420 | 73709 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 468 | 7 | 0 | 4 | 6.8 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL186628 | 73709 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 468 | 7 | 0 | 4 | 6.8 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| 10808132 | 64210 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 355 | 8 | 0 | 5 | 4.9 | CCCCN(CC)c1nc(C)nc(N(CC)c2c(C)cc(C)cc2C)n1 | 10.1021/jm980222w | |||
| CHEMBL165473 | 64210 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 355 | 8 | 0 | 5 | 4.9 | CCCCN(CC)c1nc(C)nc(N(CC)c2c(C)cc(C)cc2C)n1 | 10.1021/jm980222w | |||
| 44392766 | 72105 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(C)cc3N(C)C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL182915 | 72105 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(C)cc3N(C)C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 20780080 | 151876 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 427 | 7 | 0 | 5 | 5.5 | Cc1cc(C)c(-n2c3ncccc3n3c(CN(CC4CC4)CC4CC4)c(C)nc23)c(C)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL391169 | 151876 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 427 | 7 | 0 | 5 | 5.5 | Cc1cc(C)c(-n2c3ncccc3n3c(CN(CC4CC4)CC4CC4)c(C)nc23)c(C)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| 10298158 | 71382 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 457 | 7 | 1 | 4 | 7.1 | CCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181718 | 71382 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 457 | 7 | 1 | 4 | 7.1 | CCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| 18691327 | 104967 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 427 | 5 | 0 | 3 | 6.6 | CCN(c1nc(C)cc(-c2ccccc2F)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL274081 | 104967 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 427 | 5 | 0 | 3 | 6.6 | CCN(c1nc(C)cc(-c2ccccc2F)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 10789842 | 64901 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 453 | 9 | 0 | 9 | 2.7 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(N(C)C)cc1C(F)(F)F | 10.1021/jm980224g | |||
| CHEMBL167717 | 64901 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 453 | 9 | 0 | 9 | 2.7 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(N(C)C)cc1C(F)(F)F | 10.1021/jm980224g | |||
| 9945957 | 70719 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 341 | 8 | 1 | 4 | 5.2 | CCc1nc(-c2ccc(C)cc2OC)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1806733 | 70719 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 341 | 8 | 1 | 4 | 5.2 | CCc1nc(-c2ccc(C)cc2OC)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 11797773 | 65436 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 449 | 11 | 0 | 9 | 3.3 | COCCCN(CCOC)c1nc(C)nc2c1ncn2-c1c(Cl)cc(OC)cc1OC | 10.1021/jm980224g | |||
| CHEMBL168459 | 65436 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 449 | 11 | 0 | 9 | 3.3 | COCCCN(CCOC)c1nc(C)nc2c1ncn2-c1c(Cl)cc(OC)cc1OC | 10.1021/jm980224g | |||
| 9805117 | 71762 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 478 | 7 | 0 | 6 | 7.0 | CCCCN(CC)c1nc(C)nc2c1sc(=S)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00159-6 | |||
| CHEMBL18230 | 71762 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 478 | 7 | 0 | 6 | 7.0 | CCCCN(CC)c1nc(C)nc2c1sc(=S)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00159-6 | |||
| 44341455 | 171919 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 322 | 6 | 0 | 4 | 4.6 | CCCN(CCC)c1cc(C)nc2c(-c3ccccc3)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL422784 | 171919 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 322 | 6 | 0 | 4 | 4.6 | CCCN(CCC)c1cc(C)nc2c(-c3ccccc3)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 20780283 | 14100 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 408 | 7 | 0 | 4 | 5.2 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1086163 | 14100 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 408 | 7 | 0 | 4 | 5.2 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| 10528499 | 127168 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 473 | 7 | 1 | 7 | 4.1 | CCCC(Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br)C(=O)N(C)C | 10.1021/jm980224g | |||
| CHEMBL353393 | 127168 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 473 | 7 | 1 | 7 | 4.1 | CCCC(Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br)C(=O)N(C)C | 10.1021/jm980224g | |||
| 18691332 | 214894 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 424 | 5 | 1 | 4 | 6.1 | CCN(c1nc(C)cc(-c2ccccc2N)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL9795 | 214894 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 424 | 5 | 1 | 4 | 6.1 | CCN(c1nc(C)cc(-c2ccccc2N)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 44443599 | 160659 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 362 | 6 | 1 | 5 | 5.4 | Cc1ccnc(Oc2nc(C)c(NC(c3ccccc3)C(C)C)nc2C)c1 | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL398300 | 160659 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 362 | 6 | 1 | 5 | 5.4 | Cc1ccnc(Oc2nc(C)c(NC(c3ccccc3)C(C)C)nc2C)c1 | 10.1016/j.bmcl.2007.09.008 | |||
| 10646364 | 64303 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 430 | 6 | 0 | 4 | 5.9 | CCN(CC)c1cc(C)nc(N(CC)c2c(Cl)cc(Br)cc2Cl)n1 | 10.1021/jm980222w | |||
| CHEMBL166238 | 64303 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 430 | 6 | 0 | 4 | 5.9 | CCN(CC)c1cc(C)nc(N(CC)c2c(Cl)cc(Br)cc2Cl)n1 | 10.1021/jm980222w | |||
| 11797409 | 64613 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 440 | 7 | 0 | 6 | 4.0 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(S(C)(=O)=O)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL167171 | 64613 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 440 | 7 | 0 | 6 | 4.0 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(S(C)(=O)=O)cc2Br)n1 | 10.1021/jm980222w | |||
| 10501643 | 64640 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 408 | 7 | 0 | 5 | 5.3 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(SC)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL167195 | 64640 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 408 | 7 | 0 | 5 | 5.3 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(SC)cc2Br)n1 | 10.1021/jm980222w | |||
| 44347223 | 22027 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 352 | 7 | 0 | 5 | 4.6 | CCCN(CCC)c1cc(C)nc2c(-c3cccc(OC)c3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL121183 | 22027 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 352 | 7 | 0 | 5 | 4.6 | CCCN(CCC)c1cc(C)nc2c(-c3cccc(OC)c3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 44341736 | 16985 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 362 | 4 | 0 | 4 | 5.1 | CCCN(C)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL116003 | 16985 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 362 | 4 | 0 | 4 | 5.1 | CCCN(C)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 15490815 | 11314 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 487 | 5 | 0 | 3 | 7.3 | CCN(c1nc(C)cc(-c2ccccc2Br)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL10237 | 11314 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 487 | 5 | 0 | 3 | 7.3 | CCN(c1nc(C)cc(-c2ccccc2Br)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 20780276 | 130713 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 474 | 6 | 0 | 4 | 5.6 | CCc1nc2n(c1C(=O)N(CC1CC1)CC(F)(F)F)CCN2c1c(C)cc(Cl)cc1Cl | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL362815 | 130713 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 474 | 6 | 0 | 4 | 5.6 | CCc1nc2n(c1C(=O)N(CC1CC1)CC(F)(F)F)CCN2c1c(C)cc(Cl)cc1Cl | 10.1016/j.bmcl.2005.05.117 | |||
| 44307879 | 109048 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 349 | 4 | 1 | 5 | 4.5 | CCCNc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL303272 | 109048 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 349 | 4 | 1 | 5 | 4.5 | CCCNc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 11282946 | 70140 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 440 | 11 | 0 | 6 | 5.8 | CCCCC(c1ccc(F)cc1)N(CCC)c1nc(-c2ccc(OC)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL179540 | 70140 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 440 | 11 | 0 | 6 | 5.8 | CCCCC(c1ccc(F)cc1)N(CCC)c1nc(-c2ccc(OC)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 11351594 | 131541 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 458 | 8 | 0 | 7 | 5.2 | CCCN(Cc1cccc(OC)c1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL364214 | 131541 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 458 | 8 | 0 | 7 | 5.2 | CCCN(Cc1cccc(OC)c1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 10667729 | 65852 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 384 | 8 | 0 | 8 | 2.5 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL169576 | 65852 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 384 | 8 | 0 | 8 | 2.5 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| 44266439 | 215159 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 466 | 5 | 0 | 4 | 7.1 | CCN(c1nc(C)cc(-c2c(C)cc(C)nc2C)n1)c1c(C)cc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL9956 | 215159 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 466 | 5 | 0 | 4 | 7.1 | CCN(c1nc(C)cc(-c2c(C)cc(C)nc2C)n1)c1c(C)cc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 20780041 | 132074 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 506 | 7 | 0 | 4 | 7.2 | FC(F)(F)c1nc2n(-c3ccc(Cl)cc3Cl)c3ccccc3n2c1CN(CC1CC1)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL364537 | 132074 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 506 | 7 | 0 | 4 | 7.2 | FC(F)(F)c1nc2n(-c3ccc(Cl)cc3Cl)c3ccccc3n2c1CN(CC1CC1)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| 3533 | 7989 | 24 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 482 | 8 | 0 | 4 | 7.5 | C#CCN([C@H](c1ccc(c(c1)F)C)CC1CC1)c1sc(c(n1)c1cc(C)c(cc1Cl)OC)C | 10.1016/j.bmcl.2004.02.053 | |||
| 5282340 | 7989 | 24 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 482 | 8 | 0 | 4 | 7.5 | C#CCN([C@H](c1ccc(c(c1)F)C)CC1CC1)c1sc(c(n1)c1cc(C)c(cc1Cl)OC)C | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL291657 | 7989 | 24 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 482 | 8 | 0 | 4 | 7.5 | C#CCN([C@H](c1ccc(c(c1)F)C)CC1CC1)c1sc(c(n1)c1cc(C)c(cc1Cl)OC)C | 10.1016/j.bmcl.2004.02.053 | |||
| 44305973 | 107325 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 433 | 10 | 0 | 6 | 5.5 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)[C@@H](c1ccccc1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL291419 | 107325 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 433 | 10 | 0 | 6 | 5.5 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)[C@@H](c1ccccc1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| 18672262 | 69410 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 473 | 8 | 1 | 4 | 7.7 | CCCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC(C)C | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL178375 | 69410 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 473 | 8 | 1 | 4 | 7.7 | CCCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC(C)C | 10.1016/j.bmcl.2004.10.055 | |||
| 11751505 | 131436 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 458 | 7 | 0 | 6 | 5.2 | CCCN(CCC)c1c(Br)c(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL364168 | 131436 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 458 | 7 | 0 | 6 | 5.2 | CCCN(CCC)c1c(Br)c(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 10316753 | 67265 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 364 | 7 | 1 | 3 | 5.2 | CCCN(c1n[nH]c(-c2ccc(Cl)cc2Cl)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL175536 | 67265 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 364 | 7 | 1 | 3 | 5.2 | CCCN(c1n[nH]c(-c2ccc(Cl)cc2Cl)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| 10692645 | 65871 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 404 | 6 | 1 | 7 | 3.5 | COCCNc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169693 | 65871 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 404 | 6 | 1 | 7 | 3.5 | COCCNc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44443602 | 100812 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 376 | 8 | 1 | 5 | 5.7 | CCc1nc(Oc2ncccc2C)c(CC)nc1NC(CC)c1ccccc1 | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL248816 | 100812 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 376 | 8 | 1 | 5 | 5.7 | CCc1nc(Oc2ncccc2C)c(CC)nc1NC(CC)c1ccccc1 | 10.1016/j.bmcl.2007.09.008 | |||
| 44460263 | 212104 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 5.7 | Cc1ccc(N[C@@H](C(=O)CCc2ccncc2)c2ccccc2C)c(Cl)c1 | 10.1021/jm049974i | |||
| CHEMBL79502 | 212104 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 5.7 | Cc1ccc(N[C@@H](C(=O)CCc2ccncc2)c2ccccc2C)c(Cl)c1 | 10.1021/jm049974i | |||
| 21916075 | 14354 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 406 | 3 | 0 | 4 | 5.4 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN2CCCCC2)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1087805 | 14354 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 406 | 3 | 0 | 4 | 5.4 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN2CCCCC2)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| 10801589 | 168741 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 264 | 2 | 0 | 2 | 4.8 | Cc1cc(C)c2ccn(-c3ccc(C(C)C)cc3)c2n1 | 10.1021/jm980223o | |||
| CHEMBL415752 | 168741 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 264 | 2 | 0 | 2 | 4.8 | Cc1cc(C)c2ccn(-c3ccc(C(C)C)cc3)c2n1 | 10.1021/jm980223o | |||
| 20780184 | 73871 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 504 | 7 | 0 | 4 | 7.3 | CCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL187362 | 73871 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 504 | 7 | 0 | 4 | 7.3 | CCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 11452262 | 80157 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 396 | 5 | 1 | 5 | 4.9 | COc1cccc(S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL201470 | 80157 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 396 | 5 | 1 | 5 | 4.9 | COc1cccc(S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| 10596146 | 64382 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 383 | 9 | 0 | 6 | 4.1 | CCN(c1nc(C)nc(N(CCOC)CC2CC2)n1)c1c(C)cc(C)cc1C | 10.1021/jm980222w | |||
| CHEMBL166807 | 64382 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 383 | 9 | 0 | 6 | 4.1 | CCN(c1nc(C)nc(N(CCOC)CC2CC2)n1)c1c(C)cc(C)cc1C | 10.1021/jm980222w | |||
| 10504356 | 127510 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 464 | 11 | 0 | 6 | 4.9 | CCN(c1nc(C)cc(N(CCOC)CCOC)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980222w | |||
| CHEMBL354859 | 127510 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 464 | 11 | 0 | 6 | 4.9 | CCN(c1nc(C)cc(N(CCOC)CCOC)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980222w | |||
| 44392767 | 73048 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 367 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(C)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL184694 | 73048 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 367 | 7 | 0 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(C)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 10807869 | 65549 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 351 | 6 | 0 | 5 | 4.7 | CCCCN(CC)c1nc(C)nc2c1ncn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL168731 | 65549 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 351 | 6 | 0 | 5 | 4.7 | CCCCN(CC)c1nc(C)nc2c1ncn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| 44307653 | 108933 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 363 | 5 | 1 | 5 | 4.9 | CCCCNc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL302589 | 108933 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 363 | 5 | 1 | 5 | 4.9 | CCCCNc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 10119101 | 139186 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 525 | 8 | 1 | 4 | 8.4 | CCCN(Cc1ccc(F)cc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL369734 | 139186 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 525 | 8 | 1 | 4 | 8.4 | CCCN(Cc1ccc(F)cc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 11639847 | 134291 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 396 | 5 | 0 | 5 | 5.1 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3OC)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL366179 | 134291 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 396 | 5 | 0 | 5 | 5.1 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3OC)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 10788201 | 65773 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 418 | 6 | 2 | 7 | 3.6 | CCC(CO)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169035 | 65773 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 418 | 6 | 2 | 7 | 3.6 | CCC(CO)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 10573217 | 127273 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 402 | 5 | 0 | 6 | 4.3 | CCN(CC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL354398 | 127273 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 402 | 5 | 0 | 6 | 4.3 | CCN(CC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 20780155 | 74139 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 518 | 8 | 0 | 4 | 7.7 | CCCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL188623 | 74139 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 518 | 8 | 0 | 4 | 7.7 | CCCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 44305986 | 108902 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 425 | 9 | 0 | 7 | 5.1 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C1(c2cccs2)CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL302396 | 108902 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 425 | 9 | 0 | 7 | 5.1 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C1(c2cccs2)CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| 11236826 | 147769 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 473 | 7 | 1 | 6 | 5.9 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCc3ccccn3)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL382347 | 147769 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 473 | 7 | 1 | 6 | 5.9 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCc3ccccn3)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| 44443592 | 161771 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 362 | 7 | 1 | 5 | 5.3 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1NC(C)c1ccccc1 | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL401327 | 161771 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 362 | 7 | 1 | 5 | 5.3 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1NC(C)c1ccccc1 | 10.1016/j.bmcl.2007.09.008 | |||
| 10668655 | 31578 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 398 | 7 | 1 | 4 | 6.1 | CCCN(CC1CC1)c1cc(Nc2cc(Cl)c(Cl)cc2Cl)nc(C)n1 | 10.1021/jm960149e | |||
| CHEMBL134475 | 31578 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 398 | 7 | 1 | 4 | 6.1 | CCCN(CC1CC1)c1cc(Nc2cc(Cl)c(Cl)cc2Cl)nc(C)n1 | 10.1021/jm960149e | |||
| 10573027 | 211811 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 398 | 7 | 1 | 4 | 6.1 | CCCN(CC1CC1)c1cc(Nc2c(Cl)cc(Cl)cc2Cl)nc(C)n1 | 10.1021/jm9900117 | |||
| CHEMBL77006 | 211811 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 398 | 7 | 1 | 4 | 6.1 | CCCN(CC1CC1)c1cc(Nc2c(Cl)cc(Cl)cc2Cl)nc(C)n1 | 10.1021/jm9900117 | |||
| 44386385 | 66842 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 382 | 6 | 0 | 7 | 3.4 | CCCN(CCC)c1nc(C)nc2c1n(C)c(=O)n2-c1c(C)cc(C)nc1C | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL173780 | 66842 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 382 | 6 | 0 | 7 | 3.4 | CCCN(CCC)c1nc(C)nc2c1n(C)c(=O)n2-c1c(C)cc(C)nc1C | 10.1016/s0960-894x(99)00108-0 | |||
| 20780137 | 74174 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 482 | 7 | 0 | 4 | 7.2 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)CC1CCC1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL188813 | 74174 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 482 | 7 | 0 | 4 | 7.2 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)CC1CCC1 | 10.1016/j.bmcl.2005.06.028 | |||
| 10667355 | 64229 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 377 | 5 | 0 | 4 | 5.1 | CCN(c1nc(C)cc(C)n1)c1c(Br)cc(C(C)C)cc1OC | 10.1021/jm980222w | |||
| CHEMBL165589 | 64229 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 377 | 5 | 0 | 4 | 5.1 | CCN(c1nc(C)cc(C)n1)c1c(Br)cc(C(C)C)cc1OC | 10.1021/jm980222w | |||
| 10813479 | 64259 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 450 | 8 | 0 | 5 | 6.4 | CCN(CC)c1cc(C)nc(N(CC)c2c(Br)cc(C(C)C)cc2SC)n1 | 10.1021/jm980222w | |||
| CHEMBL165873 | 64259 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 450 | 8 | 0 | 5 | 6.4 | CCN(CC)c1cc(C)nc(N(CC)c2c(Br)cc(C(C)C)cc2SC)n1 | 10.1021/jm980222w | |||
| 44392761 | 129122 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 385 | 10 | 0 | 6 | 4.0 | CCCN(CC1CC1)c1cc(Cc2c(OC)cc(OC)cc2OC)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL359925 | 129122 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 385 | 10 | 0 | 6 | 4.0 | CCCN(CC1CC1)c1cc(Cc2c(OC)cc(OC)cc2OC)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| 9865133 | 170646 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 388 | 6 | 1 | 3 | 5.8 | CCCN(CC1CC1)c1cc(C)[nH]c2c(-c3ccc(Cl)cc3Cl)nnc1-2 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL420681 | 170646 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 388 | 6 | 1 | 3 | 5.8 | CCCN(CC1CC1)c1cc(C)[nH]c2c(-c3ccc(Cl)cc3Cl)nnc1-2 | 10.1016/s0960-894x(03)00621-8 | |||
| 20780016 | 71950 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 498 | 6 | 0 | 4 | 5.4 | CCc1nc2n(c1C(=O)N(CC1CC1)CC(F)(F)F)CCN2c1c(C)cc(C)cc1Br | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL182482 | 71950 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 498 | 6 | 0 | 4 | 5.4 | CCc1nc2n(c1C(=O)N(CC1CC1)CC(F)(F)F)CCN2c1c(C)cc(C)cc1Br | 10.1016/j.bmcl.2005.05.117 | |||
| 53310277 | 70758 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 403 | 8 | 0 | 3 | 6.2 | CCc1nc(N(CC2CC2)CC2CC2)c(CC)nc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| CHEMBL1807024 | 70758 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 403 | 8 | 0 | 3 | 6.2 | CCc1nc(N(CC2CC2)CC2CC2)c(CC)nc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| 20780089 | 174552 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 399 | 7 | 0 | 5 | 5.1 | C=CCN(CC=C)Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL430391 | 174552 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 399 | 7 | 0 | 5 | 5.1 | C=CCN(CC=C)Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 44446727 | 101610 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 376 | 7 | 0 | 3 | 6.5 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(OC)cc2C)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL253700 | 101610 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 376 | 7 | 0 | 3 | 6.5 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(OC)cc2C)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 10163122 | 71607 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 483 | 8 | 1 | 4 | 7.5 | FC(F)(F)c1nc(Nc2c(Cl)cc(Cl)cc2Cl)sc1CN(CC1CC1)CC1CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181980 | 71607 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 483 | 8 | 1 | 4 | 7.5 | FC(F)(F)c1nc(Nc2c(Cl)cc(Cl)cc2Cl)sc1CN(CC1CC1)CC1CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| 11350066 | 175052 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 398 | 8 | 0 | 5 | 5.5 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)C(CC)c1ccccc1 | 10.1021/jm049339c | |||
| CHEMBL433940 | 175052 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 398 | 8 | 0 | 5 | 5.5 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)C(CC)c1ccccc1 | 10.1021/jm049339c | |||
| 11394728 | 12446 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 374 | 8 | 0 | 5 | 4.5 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL107786 | 12446 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 374 | 8 | 0 | 5 | 4.5 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| 44385520 | 136984 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 523 | 8 | 0 | 7 | 5.0 | COCCN(Cc1ccccc1)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL367920 | 136984 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 523 | 8 | 0 | 7 | 5.0 | COCCN(Cc1ccccc1)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 44318102 | 212836 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 399 | 10 | 0 | 6 | 4.3 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2OC)n(CC2CC2)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL85363 | 212836 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 399 | 10 | 0 | 6 | 4.3 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2OC)n(CC2CC2)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 21916125 | 13479 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 506 | 7 | 0 | 4 | 7.3 | CCCN(Cc1cccc(F)c1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083613 | 13479 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 506 | 7 | 0 | 4 | 7.3 | CCCN(Cc1cccc(F)c1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 11211248 | 72943 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 382 | 7 | 1 | 7 | 3.6 | CCC(COC)Nc1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL184284 | 72943 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 382 | 7 | 1 | 7 | 3.6 | CCC(COC)Nc1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 10292638 | 124844 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 371 | 7 | 1 | 4 | 5.4 | CCCN(CC1CC1)C(=O)c1sc(Nc2c(C)cc(C)cc2C)nc1C | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL340469 | 124844 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 371 | 7 | 1 | 4 | 5.4 | CCCN(CC1CC1)C(=O)c1sc(Nc2c(C)cc(C)cc2C)nc1C | 10.1016/j.bmcl.2003.08.055 | |||
| 11427630 | 69784 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 334 | 7 | 0 | 5 | 3.8 | CCCN(CC1CC1)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL178725 | 69784 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 334 | 7 | 0 | 5 | 3.8 | CCCN(CC1CC1)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 44337533 | 174648 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 326 | 6 | 0 | 4 | 4.4 | CCCN(CCC)c1nc(-c2ccc(Cl)cc2Cl)n(C)n1 | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL431067 | 174648 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 326 | 6 | 0 | 4 | 4.4 | CCCN(CCC)c1nc(-c2ccc(Cl)cc2Cl)n(C)n1 | 10.1016/s0960-894x(01)00657-6 | |||
| 44446736 | 101405 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 433 | 10 | 0 | 4 | 6.4 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OCCN(C)C)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL252302 | 101405 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 433 | 10 | 0 | 4 | 6.4 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OCCN(C)C)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 44443627 | 160806 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 422 | 9 | 1 | 6 | 4.9 | CCc1nc(Oc2ccccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OCCF | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL398425 | 160806 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 422 | 9 | 1 | 6 | 4.9 | CCc1nc(Oc2ccccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OCCF | 10.1016/j.bmcl.2007.09.008 | |||
| 10599448 | 65609 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 444 | 7 | 0 | 6 | 4.4 | CCN(CCN(C)C)c1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL168846 | 65609 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 444 | 7 | 0 | 6 | 4.4 | CCN(CCN(C)C)c1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 11351416 | 80689 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 450 | 5 | 1 | 5 | 5.8 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL201966 | 80689 | 0 | None | - | 1 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 450 | 5 | 1 | 5 | 5.8 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| 10835160 | 64211 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 405 | 7 | 0 | 5 | 4.6 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(N(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL165475 | 64211 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 405 | 7 | 0 | 5 | 4.6 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(N(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 10621342 | 127219 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 405 | 7 | 0 | 5 | 5.1 | CCN(CC)c1nc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL353890 | 127219 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 405 | 7 | 0 | 5 | 5.1 | CCN(CC)c1nc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 53309695 | 70774 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 5.7 | CCC(CC)Nc1nc(C)c(-c2ccc(Cl)cc2Cl)nc1C | 10.1021/jm200365y | |||
| CHEMBL1807040 | 70774 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 337 | 5 | 1 | 3 | 5.7 | CCC(CC)Nc1nc(C)c(-c2ccc(Cl)cc2Cl)nc1C | 10.1021/jm200365y | |||
| 21916306 | 14449 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 488 | 6 | 0 | 4 | 6.5 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN(CC2CCC2)CC(F)(F)F)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1088624 | 14449 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 488 | 6 | 0 | 4 | 6.5 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN(CC2CCC2)CC(F)(F)F)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| 10618927 | 65820 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 366 | 5 | 2 | 5 | 4.5 | CCC(CO)Nc1nc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL169418 | 65820 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 366 | 5 | 2 | 5 | 4.5 | CCC(CO)Nc1nc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| 10784215 | 66546 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 352 | 6 | 0 | 6 | 4.1 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL172571 | 66546 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 352 | 6 | 0 | 6 | 4.1 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| 44341476 | 16841 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 392 | 8 | 0 | 4 | 6.3 | CCCCN(CCCC)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL115313 | 16841 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 392 | 8 | 0 | 4 | 6.3 | CCCCN(CCCC)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 10764399 | 65840 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 416 | 7 | 1 | 7 | 4.1 | COCC(Cc1ccccc1)Nc1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL169538 | 65840 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 416 | 7 | 1 | 7 | 4.1 | COCC(Cc1ccccc1)Nc1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| 135958361 | 63962 | 0 | None | 3 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 428 | 3 | 4 | 7 | 2.4 | NCCNC(=O)c1c2c(c3c(O)c4ccccc4c4ncnc1c34)=N[C@H]1CCCC[C@H]1N2 | 10.1016/s0960-894x(99)00075-x | |||
| CHEMBL164931 | 63962 | 0 | None | 3 | 2 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 428 | 3 | 4 | 7 | 2.4 | NCCNC(=O)c1c2c(c3c(O)c4ccccc4c4ncnc1c34)=N[C@H]1CCCC[C@H]1N2 | 10.1016/s0960-894x(99)00075-x | |||
| 20780021 | 70696 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 512 | 7 | 0 | 4 | 5.9 | CCc1nc2n(c1C(=O)N(CC1CC1)CC(F)(F)F)CCN2c1ccc(C(C)C)cc1Br | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL180613 | 70696 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 512 | 7 | 0 | 4 | 5.9 | CCc1nc2n(c1C(=O)N(CC1CC1)CC(F)(F)F)CCN2c1ccc(C(C)C)cc1Br | 10.1016/j.bmcl.2005.05.117 | |||
| 20780256 | 71073 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 518 | 7 | 0 | 4 | 6.8 | CCc1nc2n(c1C(=O)N(CCC(F)(F)F)Cc1ccc(Cl)cc1)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL181053 | 71073 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 518 | 7 | 0 | 4 | 6.8 | CCc1nc2n(c1C(=O)N(CCC(F)(F)F)Cc1ccc(Cl)cc1)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 20780055 | 100727 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 444 | 5 | 0 | 6 | 5.3 | Cc1cc(C)c(-n2c3ncccc3n3c(CN(C)Cc4cccnc4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL248367 | 100727 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 444 | 5 | 0 | 6 | 5.3 | Cc1cc(C)c(-n2c3ncccc3n3c(CN(C)Cc4cccnc4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| 44443577 | 100762 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 346 | 8 | 2 | 4 | 5.6 | CCc1nc(NC(CC)CC)c(CC)nc1Nc1ccc(Cl)cc1 | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL248588 | 100762 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 346 | 8 | 2 | 4 | 5.6 | CCc1nc(NC(CC)CC)c(CC)nc1Nc1ccc(Cl)cc1 | 10.1016/j.bmcl.2007.09.008 | |||
| 3568686 | 209844 | 8 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 287 | 4 | 2 | 3 | 3.8 | CC(=O)/C(=N\Nc1ccccc1)Nc1cccc(Cl)c1 | 10.1021/jm025512y | |||
| CHEMBL63664 | 209844 | 8 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 287 | 4 | 2 | 3 | 3.8 | CC(=O)/C(=N\Nc1ccccc1)Nc1cccc(Cl)c1 | 10.1021/jm025512y | |||
| 44587453 | 195886 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 359 | 9 | 0 | 6 | 4.1 | CCCN(CCC)c1c(C)nc(-c2c(OC)cccc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL510224 | 195886 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 359 | 9 | 0 | 6 | 4.1 | CCCN(CCC)c1c(C)nc(-c2c(OC)cccc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| 20780170 | 130630 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 490 | 6 | 0 | 4 | 7.2 | CCN(Cc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL362567 | 130630 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 490 | 6 | 0 | 4 | 7.2 | CCN(Cc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 44352478 | 27643 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 505 | 8 | 1 | 4 | 7.9 | CCCN(Cc1sc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL131046 | 27643 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 505 | 8 | 1 | 4 | 7.9 | CCCN(Cc1sc(Nc2c(Cl)cc(C(F)(F)F)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 44352464 | 28216 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 539 | 8 | 1 | 4 | 7.4 | CCCN(Cc1sc(Nc2c(Br)cc(C)cc2Br)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL131533 | 28216 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 539 | 8 | 1 | 4 | 7.4 | CCCN(Cc1sc(Nc2c(Br)cc(C)cc2Br)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 20780173 | 133949 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 454 | 6 | 0 | 4 | 6.5 | CCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL365715 | 133949 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 454 | 6 | 0 | 4 | 6.5 | CCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| 10526864 | 64336 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 434 | 8 | 0 | 6 | 4.8 | CCN(CC)c1cc(C)nc(N(CC)c2c(Br)cc(C(C)=O)cc2OC)n1 | 10.1021/jm980222w | |||
| CHEMBL166504 | 64336 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 434 | 8 | 0 | 6 | 4.8 | CCN(CC)c1cc(C)nc(N(CC)c2c(Br)cc(C(C)=O)cc2OC)n1 | 10.1021/jm980222w | |||
| 10740490 | 185462 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 413 | 3 | 0 | 4 | 5.1 | Cc1cc(N2CCOCC2)c2ccn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| CHEMBL46798 | 185462 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 413 | 3 | 0 | 4 | 5.1 | Cc1cc(N2CCOCC2)c2ccn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| 21916258 | 13477 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 522 | 7 | 0 | 4 | 7.8 | CCCN(Cc1ccc(Cl)cc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083611 | 13477 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 522 | 7 | 0 | 4 | 7.8 | CCCN(Cc1ccc(Cl)cc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 20780133 | 100462 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 471 | 7 | 0 | 5 | 6.7 | CCCN(Cc1ccccc1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL246944 | 100462 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 471 | 7 | 0 | 5 | 6.7 | CCCN(Cc1ccccc1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 20780060 | 100535 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 419 | 7 | 0 | 5 | 5.4 | C=CCN(CC=C)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL247358 | 100535 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 419 | 7 | 0 | 5 | 5.4 | C=CCN(CC=C)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 44446721 | 162286 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 362 | 7 | 0 | 3 | 6.2 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2C)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL404171 | 162286 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 362 | 7 | 0 | 3 | 6.2 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2C)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 12967653 | 71503 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 521 | 9 | 1 | 4 | 8.3 | CCCN(CCc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181884 | 71503 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 521 | 9 | 1 | 4 | 8.3 | CCCN(CCc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 11394728 | 12446 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 374 | 8 | 0 | 5 | 4.5 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)C(C1CC1)C1CC1 | 10.1021/jm049339c | |||
| CHEMBL107786 | 12446 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 374 | 8 | 0 | 5 | 4.5 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)C(C1CC1)C1CC1 | 10.1021/jm049339c | |||
| 11798947 | 65908 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 480 | 10 | 0 | 10 | 2.4 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1c(Br)cc(OC)cc1OC | 10.1021/jm980224g | |||
| CHEMBL169861 | 65908 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 480 | 10 | 0 | 10 | 2.4 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1c(Br)cc(OC)cc1OC | 10.1021/jm980224g | |||
| 44388401 | 69771 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 394 | 11 | 0 | 6 | 5.3 | CCCCC(CC)N(OCCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL178667 | 69771 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 394 | 11 | 0 | 6 | 5.3 | CCCCC(CC)N(OCCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 10180472 | 28716 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 419 | 7 | 1 | 4 | 6.4 | CCCCN(CC)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL132055 | 28716 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 419 | 7 | 1 | 4 | 6.4 | CCCCN(CC)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C | 10.1016/j.bmcl.2003.08.055 | |||
| 20780057 | 158941 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 458 | 6 | 0 | 6 | 5.3 | Cc1cc(C)c(-n2c3ncccc3n3c(CN(C)CCc4ccccn4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL396821 | 158941 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 458 | 6 | 0 | 6 | 5.3 | Cc1cc(C)c(-n2c3ncccc3n3c(CN(C)CCc4ccccn4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| 10598041 | 127090 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 416 | 7 | 0 | 6 | 4.7 | CCCCN(CC)c1ncnc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL352784 | 127090 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 416 | 7 | 0 | 6 | 4.7 | CCCCN(CC)c1ncnc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 10811877 | 172487 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 416 | 5 | 0 | 4 | 5.8 | CCN(c1nc(C)cc(N2CCCCC2)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980222w | |||
| CHEMBL424562 | 172487 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 416 | 5 | 0 | 4 | 5.8 | CCN(c1nc(C)cc(N2CCCCC2)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980222w | |||
| 10665582 | 127187 | 1 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 350 | 5 | 1 | 4 | 5.5 | CCCCNc1nc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL353638 | 127187 | 1 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 350 | 5 | 1 | 4 | 5.5 | CCCCNc1nc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| 44347190 | 22054 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 384 | 8 | 1 | 7 | 3.2 | CCCN(CCO)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL121301 | 22054 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 384 | 8 | 1 | 7 | 3.2 | CCCN(CCO)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 10548172 | 65902 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 385 | 3 | 0 | 5 | 4.3 | COc1cc(Br)c(-n2cc(C#N)c3c(C)cc(C)nc32)c(OC)c1 | 10.1021/jm980223o | |||
| CHEMBL169838 | 65902 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 385 | 3 | 0 | 5 | 4.3 | COc1cc(Br)c(-n2cc(C#N)c3c(C)cc(C)nc32)c(OC)c1 | 10.1021/jm980223o | |||
| 44308157 | 210641 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 419 | 8 | 0 | 5 | 6.1 | CCCCCCN(CC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL68697 | 210641 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 419 | 8 | 0 | 5 | 6.1 | CCCCCCN(CC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 20780274 | 69767 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 382 | 7 | 0 | 4 | 4.8 | CCCCN(CC)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL178617 | 69767 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 382 | 7 | 0 | 4 | 4.8 | CCCCN(CC)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 10164483 | 129530 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 508 | 8 | 1 | 5 | 7.7 | CCCN(Cc1cccnc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL360458 | 129530 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 508 | 8 | 1 | 5 | 7.7 | CCCN(Cc1cccnc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 10183075 | 138228 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 459 | 8 | 1 | 4 | 7.5 | CCCCN(CC)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL369109 | 138228 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 459 | 8 | 1 | 4 | 7.5 | CCCCN(CC)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 44352437 | 28134 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 489 | 9 | 1 | 4 | 7.4 | CCCN(Cc1sc(Nc2ccc(C(C)C)cc2Br)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL131422 | 28134 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 489 | 9 | 1 | 4 | 7.4 | CCCN(Cc1sc(Nc2ccc(C(C)C)cc2Br)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 44441102 | 158944 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 5.5 | CCCC(C)NCc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL396822 | 158944 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 409 | 6 | 1 | 5 | 5.5 | CCCC(C)NCc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 44389083 | 69409 | 0 | None | - | 1 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 429 | 6 | 2 | 4 | 6.4 | FC(F)(F)c1nc(Nc2c(Cl)cc(Cl)cc2Cl)sc1CNCC1CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL178374 | 69409 | 0 | None | - | 1 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 429 | 6 | 2 | 4 | 6.4 | FC(F)(F)c1nc(Nc2c(Cl)cc(Cl)cc2Cl)sc1CNCC1CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| 10914632 | 169465 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 335 | 4 | 2 | 3 | 4.3 | CC(=O)/C(=N\c1cccc(C(F)(F)F)c1)NNc1ccccc1C | 10.1021/jm025512y | |||
| CHEMBL417037 | 169465 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 335 | 4 | 2 | 3 | 4.3 | CC(=O)/C(=N\c1cccc(C(F)(F)F)c1)NNc1ccccc1C | 10.1021/jm025512y | |||
| 44397564 | 74427 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 550 | 6 | 0 | 4 | 7.5 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCC(F)(F)F)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL190638 | 74427 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 550 | 6 | 0 | 4 | 7.5 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCC(F)(F)F)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| 10549983 | 65648 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 418 | 7 | 1 | 7 | 3.9 | COCCCNc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL168883 | 65648 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 418 | 7 | 1 | 7 | 3.9 | COCCCNc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 11022531 | 210567 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 287 | 4 | 2 | 3 | 3.6 | CC(=O)/C(=N\c1ccccc1)NNc1ccccc1Cl | 10.1021/jm025512y | |||
| CHEMBL68238 | 210567 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 287 | 4 | 2 | 3 | 3.6 | CC(=O)/C(=N\c1ccccc1)NNc1ccccc1Cl | 10.1021/jm025512y | |||
| CHEMBL413591 | 219855 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N1)[C@@H](C)CC)C(N)=O | 10.1021/jm034180+ | |||||
| 10765122 | 64936 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 430 | 9 | 0 | 6 | 4.3 | C=CCN(CC=C)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL168131 | 64936 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 430 | 9 | 0 | 6 | 4.3 | C=CCN(CC=C)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 44386432 | 66363 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 458 | 7 | 0 | 5 | 5.5 | CCCCN(CC)c1cc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL171893 | 66363 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 458 | 7 | 0 | 5 | 5.5 | CCCCN(CC)c1cc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 9955329 | 214609 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 448 | 8 | 0 | 8 | 3.9 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1c(Br)cc(OC)cc1OC | 10.1021/jm980224g | |||
| CHEMBL9633 | 214609 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 448 | 8 | 0 | 8 | 3.9 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1c(Br)cc(OC)cc1OC | 10.1021/jm980224g | |||
| 44340885 | 16931 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00661-2 | |||||
| CHEMBL115836 | 16931 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00661-2 | |||||
| 44341765 | 16563 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 374 | 7 | 0 | 2 | 7.2 | CCCCN(CCC)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL113653 | 16563 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 374 | 7 | 0 | 2 | 7.2 | CCCCN(CCC)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 44342075 | 174652 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 360 | 6 | 0 | 2 | 6.8 | CCCN(CCC)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL431076 | 174652 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 360 | 6 | 0 | 2 | 6.8 | CCCN(CCC)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 44307478 | 109407 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.7 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/j.bmc.2017.10.012 | |||
| CHEMBL304272 | 109407 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.7 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/j.bmc.2017.10.012 | |||
| 44307474 | 109415 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 377 | 5 | 0 | 5 | 4.9 | CCCN(CC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/j.bmc.2017.10.012 | |||
| CHEMBL304335 | 109415 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 377 | 5 | 0 | 5 | 4.9 | CCCN(CC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/j.bmc.2017.10.012 | |||
| CHEMBL4299313 | 220344 | 0 | None | -2 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)(C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC(=O)C(CCCC)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(=O)O)NC(=O)CCOCCOCCOCCOCCOCCOCCN)[C@@H](C)O)C(C)C)C(=O)N[C@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||||
| 3520 | 10041 | 54 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2015.10.010 | |||
| 9821250 | 10041 | 54 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL309138 | 10041 | 54 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2015.10.010 | |||
| 44307478 | 109407 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.7 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL304272 | 109407 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.7 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 44307474 | 109415 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 377 | 5 | 0 | 5 | 4.9 | CCCN(CC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL304335 | 109415 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 377 | 5 | 0 | 5 | 4.9 | CCCN(CC)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 44307892 | 210256 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 379 | 7 | 0 | 5 | 5.4 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(C)cc3C)n(CC)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL66054 | 210256 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 379 | 7 | 0 | 5 | 5.4 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(C)cc3C)n(CC)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 9885480 | 210291 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 365 | 6 | 0 | 5 | 4.9 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(C)cc3C)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL66275 | 210291 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 365 | 6 | 0 | 5 | 4.9 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(C)cc3C)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 3495 | 7958 | 28 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2008.07.063 | |||
| 5311055 | 7958 | 28 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL9946 | 7958 | 28 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2008.07.063 | |||
| 3520 | 10041 | 54 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2008.07.063 | |||
| 9821250 | 10041 | 54 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL309138 | 10041 | 54 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL407570 | 219447 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(C)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N1)[C@@H](C)CC)C(N)=O | 10.1021/jm034180+ | |||||
| 177990 | 7214 | 23 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1021/jm050384+ | |||
| 3489 | 7214 | 23 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1021/jm050384+ | |||
| CHEMBL296641 | 7214 | 23 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1021/jm050384+ | |||
| 10694630 | 65935 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 444 | 8 | 1 | 6 | 5.8 | CCCCC(CC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169952 | 65935 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 444 | 8 | 1 | 6 | 5.8 | CCCCC(CC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 9912938 | 11235 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 477 | 5 | 0 | 3 | 7.5 | CCN(c1nc(C)cc(-c2ccccc2C(F)(F)F)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL10175 | 11235 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 477 | 5 | 0 | 3 | 7.5 | CCN(c1nc(C)cc(-c2ccccc2C(F)(F)F)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 122193723 | 130742 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 458 | 7 | 1 | 4 | 6.0 | CCCN(CCC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628743 | 130742 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 458 | 7 | 1 | 4 | 6.0 | CCCN(CCC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)C)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| 177990 | 7214 | 23 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1021/jm050070m | |||
| 3489 | 7214 | 23 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1021/jm050070m | |||
| CHEMBL296641 | 7214 | 23 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 10.1021/jm050070m | |||
| 11025 | 9517 | 7 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 400 | 4 | 0 | 4 | 5.7 | CC[C@H]1Cn2nc(c3c2c(N1CC1CC1)cc(n3)C)c1ccc(cc1Cl)Cl | 10.1021/jm049085v | |||
| 11713007 | 9517 | 7 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 400 | 4 | 0 | 4 | 5.7 | CC[C@H]1Cn2nc(c3c2c(N1CC1CC1)cc(n3)C)c1ccc(cc1Cl)Cl | 10.1021/jm049085v | |||
| CHEMBL380800 | 9517 | 7 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 400 | 4 | 0 | 4 | 5.7 | CC[C@H]1Cn2nc(c3c2c(N1CC1CC1)cc(n3)C)c1ccc(cc1Cl)Cl | 10.1021/jm049085v | |||
| 44392707 | 70532 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 407 | 7 | 0 | 6 | 4.6 | CCCN(CCOC)c1cc(C)nc2c(-c3ncc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL180142 | 70532 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 407 | 7 | 0 | 6 | 4.6 | CCCN(CCOC)c1cc(C)nc2c(-c3ncc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 44392688 | 73089 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL184930 | 73089 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 391 | 6 | 0 | 5 | 5.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 10622522 | 66223 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 429 | 7 | 0 | 5 | 5.6 | CCCCN(CC)c1cc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL171202 | 66223 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 429 | 7 | 0 | 5 | 5.6 | CCCCN(CC)c1cc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44342014 | 16315 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 392 | 6 | 0 | 5 | 4.7 | CCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL112290 | 16315 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 392 | 6 | 0 | 5 | 4.7 | CCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 44341754 | 16806 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 408 | 6 | 0 | 2 | 7.6 | CCCN(Cc1ccccc1)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL115099 | 16806 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 408 | 6 | 0 | 2 | 7.6 | CCCN(Cc1ccccc1)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 11774042 | 210131 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| CHEMBL65078 | 210131 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 402 | 6 | 0 | 4 | 5.9 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| 9960282 | 71098 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 595 | 8 | 1 | 4 | 9.5 | FC(F)(F)CCN(Cc1ccc(Cl)cc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181134 | 71098 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 595 | 8 | 1 | 4 | 9.5 | FC(F)(F)CCN(Cc1ccc(Cl)cc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 9952376 | 16645 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL114193 | 16645 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| 9952376 | 16645 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL114193 | 16645 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 9843355 | 18002 | 2 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 389 | 7 | 1 | 7 | 4.0 | COCC(COC)n1nnc2c(Nc3c(C)cc(C)cc3Cl)nc(C)cc21 | 10.1021/jm990590f | |||
| CHEMBL1178813 | 18002 | 2 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 389 | 7 | 1 | 7 | 4.0 | COCC(COC)n1nnc2c(Nc3c(C)cc(C)cc3Cl)nc(C)cc21 | 10.1021/jm990590f | |||
| CHEMBL44169 | 18002 | 2 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 389 | 7 | 1 | 7 | 4.0 | COCC(COC)n1nnc2c(Nc3c(C)cc(C)cc3Cl)nc(C)cc21 | 10.1021/jm990590f | |||
| 9865624 | 22316 | 12 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 398 | 9 | 0 | 7 | 3.9 | CCCN(CCOC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL121896 | 22316 | 12 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 398 | 9 | 0 | 7 | 3.9 | CCCN(CCOC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 11384238 | 73624 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 406 | 6 | 1 | 4 | 5.4 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL186203 | 73624 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 406 | 6 | 1 | 4 | 5.4 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2015.10.010 | |||
| 122193716 | 130732 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 478 | 6 | 1 | 4 | 5.0 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(I)cc1C | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628732 | 130732 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 478 | 6 | 1 | 4 | 5.0 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(I)cc1C | 10.1016/j.bmcl.2015.10.010 | |||
| 9865624 | 22316 | 12 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 398 | 9 | 0 | 7 | 3.9 | CCCN(CCOC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL121896 | 22316 | 12 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 398 | 9 | 0 | 7 | 3.9 | CCCN(CCOC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1021/jm040058e | |||
| 11305029 | 73703 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 432 | 6 | 0 | 6 | 4.9 | CCN(Cc1ccccc1F)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL186592 | 73703 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 432 | 6 | 0 | 6 | 4.9 | CCN(Cc1ccccc1F)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 10789622 | 127517 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 447 | 8 | 0 | 7 | 4.5 | CCCCN(CC)c1nc(C)nc2c1ncn2-c1c(Br)cc(OC)cc1OC | 10.1021/jm980224g | |||
| CHEMBL354940 | 127517 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 447 | 8 | 0 | 7 | 4.5 | CCCCN(CC)c1nc(C)nc2c1ncn2-c1c(Br)cc(OC)cc1OC | 10.1021/jm980224g | |||
| 10835789 | 172101 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 417 | 8 | 0 | 7 | 4.7 | CCCCN(CC)c1nc(C)nc2c1nc(C)n2-c1c(Cl)cc(OC)cc1OC | 10.1021/jm980224g | |||
| CHEMBL423444 | 172101 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 417 | 8 | 0 | 7 | 4.7 | CCCCN(CC)c1nc(C)nc2c1nc(C)n2-c1c(Cl)cc(OC)cc1OC | 10.1021/jm980224g | |||
| 10835759 | 175309 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 416 | 6 | 0 | 5 | 5.6 | CCC(CC)Oc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL435468 | 175309 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 416 | 6 | 0 | 5 | 5.6 | CCC(CC)Oc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44347236 | 120087 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 347 | 6 | 0 | 5 | 4.5 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(C#N)cc3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL331539 | 120087 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 347 | 6 | 0 | 5 | 4.5 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(C#N)cc3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 10363370 | 126653 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 396 | 7 | 0 | 4 | 5.8 | CCN(CCCCF)c1nc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(00)00071-8 | |||
| CHEMBL348967 | 126653 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 396 | 7 | 0 | 4 | 5.8 | CCN(CCCCF)c1nc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(00)00071-8 | |||
| CHEMBL4299313 | 220344 | 0 | None | -2 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)(C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC(=O)C(CCCC)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(=O)O)NC(=O)CCOCCOCCOCCOCCOCCOCCN)[C@@H](C)O)C(C)C)C(=O)N[C@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||||
| 3520 | 10041 | 54 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm040058e | |||
| 9821250 | 10041 | 54 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm040058e | |||
| CHEMBL309138 | 10041 | 54 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm040058e | |||
| 11189666 | 77970 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 395 | 6 | 0 | 3 | 6.6 | CCCC(CCC)N1CCc2cn(-c3ccc(C)cc3Cl)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL195631 | 77970 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 395 | 6 | 0 | 3 | 6.6 | CCCC(CCC)N1CCc2cn(-c3ccc(C)cc3Cl)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 44381516 | 65823 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 443 | 8 | 1 | 5 | 6.4 | CCCC(CCC)Nc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169430 | 65823 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 443 | 8 | 1 | 5 | 6.4 | CCCC(CCC)Nc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44347217 | 103405 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 352 | 7 | 0 | 5 | 4.6 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(OC)cc3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL263492 | 103405 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 352 | 7 | 0 | 5 | 4.6 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(OC)cc3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 3495 | 7958 | 28 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2003.08.055 | |||
| 5311055 | 7958 | 28 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL9946 | 7958 | 28 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2003.08.055 | |||
| 9934089 | 11779 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 462 | 9 | 0 | 8 | 3.5 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL10504 | 11779 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 462 | 9 | 0 | 8 | 3.5 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44341813 | 16375 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 416 | 6 | 0 | 4 | 6.1 | Cc1cc(N(CC(C)C)CC2CC2)c2c(n1)c(-c1ccc(Cl)cc1Cl)nn2C | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL112560 | 16375 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 416 | 6 | 0 | 4 | 6.1 | Cc1cc(N(CC(C)C)CC2CC2)c2c(n1)c(-c1ccc(Cl)cc1Cl)nn2C | 10.1016/s0960-894x(03)00622-x | |||
| 9934089 | 11779 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 462 | 9 | 0 | 8 | 3.5 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm990590f | |||
| CHEMBL10504 | 11779 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 462 | 9 | 0 | 8 | 3.5 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm990590f | |||
| 3495 | 7958 | 28 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2005.05.117 | |||
| 5311055 | 7958 | 28 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL9946 | 7958 | 28 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/j.bmcl.2005.05.117 | |||
| 18449330 | 70755 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 389 | 7 | 1 | 3 | 6.2 | CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1NC(C1CC1)C1CC1 | 10.1021/jm200365y | |||
| CHEMBL1807021 | 70755 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 389 | 7 | 1 | 3 | 6.2 | CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1NC(C1CC1)C1CC1 | 10.1021/jm200365y | |||
| 10188470 | 138227 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 579 | 8 | 1 | 4 | 9.0 | Fc1cccc(CN(CCC(F)(F)F)Cc2sc(Nc3c(Cl)cc(Cl)cc3Cl)nc2C(F)(F)F)c1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL369107 | 138227 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 579 | 8 | 1 | 4 | 9.0 | Fc1cccc(CN(CCC(F)(F)F)Cc2sc(Nc3c(Cl)cc(Cl)cc3Cl)nc2C(F)(F)F)c1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL427807 | 220164 | 0 | None | -1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O | 10.1021/jm990590f | |||||
| 44341664 | 16797 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 434 | 6 | 0 | 2 | 7.9 | CCCN(Cc1ccccc1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL115030 | 16797 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 434 | 6 | 0 | 2 | 7.9 | CCCN(Cc1ccccc1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 3520 | 10041 | 54 | None | -1 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm200365y | |||
| 9821250 | 10041 | 54 | None | -1 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm200365y | |||
| CHEMBL309138 | 10041 | 54 | None | -1 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm200365y | |||
| 10550438 | 211885 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 426 | 8 | 1 | 4 | 6.7 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1CC | 10.1021/jm960149e | |||
| CHEMBL77716 | 211885 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 426 | 8 | 1 | 4 | 6.7 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1CC | 10.1021/jm960149e | |||
| 10550438 | 211885 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 426 | 8 | 1 | 4 | 6.7 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1CC | 10.1021/jm9900117 | |||
| CHEMBL77716 | 211885 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 426 | 8 | 1 | 4 | 6.7 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1CC | 10.1021/jm9900117 | |||
| 44392702 | 163639 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 403 | 6 | 0 | 5 | 5.3 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ncc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL407168 | 163639 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 403 | 6 | 0 | 5 | 5.3 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ncc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 10670904 | 127528 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 442 | 7 | 0 | 4 | 6.6 | CCCCN(CC)c1cc(C)nc2c1nc(C)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL355049 | 127528 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 442 | 7 | 0 | 4 | 6.6 | CCCCN(CC)c1cc(C)nc2c1nc(C)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44347139 | 121726 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 368 | 7 | 1 | 6 | 4.6 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL334237 | 121726 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 368 | 7 | 1 | 6 | 4.6 | CCC(CC)Nc1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 46872036 | 130733 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 366 | 6 | 1 | 4 | 4.7 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C)cc1C | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628733 | 130733 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 366 | 6 | 1 | 4 | 4.7 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C)cc1C | 10.1016/j.bmcl.2015.10.010 | |||
| 11628147 | 77335 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 434 | 4 | 0 | 4 | 6.1 | CC[C@H]1Cn2nc(-c3ccc(C(F)(F)F)cc3Cl)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL194836 | 77335 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 434 | 4 | 0 | 4 | 6.1 | CC[C@H]1Cn2nc(-c3ccc(C(F)(F)F)cc3Cl)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 11605928 | 78671 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 396 | 5 | 0 | 5 | 5.1 | CC[C@H]1Cn2nc(-c3ccc(OC)cc3Cl)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL197134 | 78671 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 396 | 5 | 0 | 5 | 5.1 | CC[C@H]1Cn2nc(-c3ccc(OC)cc3Cl)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 11560698 | 142058 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 414 | 5 | 0 | 4 | 6.1 | CCC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL372653 | 142058 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 414 | 5 | 0 | 4 | 6.1 | CCC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 11598576 | 148126 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 388 | 4 | 0 | 4 | 5.7 | CCC(CC)N1CCn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc1c32 | 10.1021/jm049085v | |||
| CHEMBL383602 | 148126 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 388 | 4 | 0 | 4 | 5.7 | CCC(CC)N1CCn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc1c32 | 10.1021/jm049085v | |||
| 11795560 | 64462 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 404 | 7 | 0 | 4 | 5.7 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL166890 | 64462 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 404 | 7 | 0 | 4 | 5.7 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 44375438 | 63334 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 408 | 7 | 0 | 4 | 5.8 | Cc1cc(C)c(-n2c(C)c(C)c3c(N(CCCF)CC4CC4)nc(C)nc32)c(C)c1 | 10.1016/s0960-894x(00)00071-8 | |||
| CHEMBL164042 | 63334 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 408 | 7 | 0 | 4 | 5.8 | Cc1cc(C)c(-n2c(C)c(C)c3c(N(CCCF)CC4CC4)nc(C)nc32)c(C)c1 | 10.1016/s0960-894x(00)00071-8 | |||
| 10048451 | 160611 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 432 | 9 | 1 | 6 | 5.6 | CCCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2cc(C)ccn2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL398258 | 160611 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 432 | 9 | 1 | 6 | 5.6 | CCCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2cc(C)ccn2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| 44446740 | 162388 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 475 | 10 | 0 | 5 | 6.2 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OCCN2CCOCC2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL404560 | 162388 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 475 | 10 | 0 | 5 | 6.2 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OCCN2CCOCC2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 10573027 | 211811 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 398 | 7 | 1 | 4 | 6.1 | CCCN(CC1CC1)c1cc(Nc2c(Cl)cc(Cl)cc2Cl)nc(C)n1 | 10.1021/jm960149e | |||
| CHEMBL77006 | 211811 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 398 | 7 | 1 | 4 | 6.1 | CCCN(CC1CC1)c1cc(Nc2c(Cl)cc(Cl)cc2Cl)nc(C)n1 | 10.1021/jm960149e | |||
| 10573027 | 211811 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 398 | 7 | 1 | 4 | 6.1 | CCCN(CC1CC1)c1cc(Nc2c(Cl)cc(Cl)cc2Cl)nc(C)n1 | 10.1021/jm9900117 | |||
| CHEMBL77006 | 211811 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 398 | 7 | 1 | 4 | 6.1 | CCCN(CC1CC1)c1cc(Nc2c(Cl)cc(Cl)cc2Cl)nc(C)n1 | 10.1021/jm9900117 | |||
| 11152649 | 75296 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 361 | 6 | 0 | 3 | 6.0 | CCCC(CCC)N1CCc2cn(-c3ccc(C)cc3)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL191755 | 75296 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 361 | 6 | 0 | 3 | 6.0 | CCCC(CCC)N1CCc2cn(-c3ccc(C)cc3)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 20780290 | 70695 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 378 | 7 | 0 | 4 | 4.3 | C=CCN(CC=C)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL180610 | 70695 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 378 | 7 | 0 | 4 | 4.3 | C=CCN(CC=C)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 20780257 | 71061 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 464 | 7 | 0 | 4 | 6.2 | CCCN(Cc1ccc(Cl)cc1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL181002 | 71061 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 464 | 7 | 0 | 4 | 6.2 | CCCN(Cc1ccc(Cl)cc1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 11798634 | 64368 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 470 | 7 | 0 | 5 | 5.3 | CCN(CC)c1cc(C)nc(N(CC)c2c(Br)cc(Br)cc2OC)n1 | 10.1021/jm980222w | |||
| CHEMBL166776 | 64368 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 470 | 7 | 0 | 5 | 5.3 | CCN(CC)c1cc(C)nc(N(CC)c2c(Br)cc(Br)cc2OC)n1 | 10.1021/jm980222w | |||
| 11792683 | 64873 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 357 | 8 | 0 | 6 | 3.7 | CCN(CCOC)c1nc(C)nc(N(CC)c2c(C)cc(C)cc2C)n1 | 10.1021/jm980222w | |||
| CHEMBL167464 | 64873 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 357 | 8 | 0 | 6 | 3.7 | CCN(CCOC)c1nc(C)nc(N(CC)c2c(C)cc(C)cc2C)n1 | 10.1021/jm980222w | |||
| 44392760 | 72016 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 391 | 9 | 0 | 4 | 5.3 | C=CCc1c(C(=O)c2c(C)cc(C)cc2C)nc(C)nc1N(CCC)CC1CC1 | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL182706 | 72016 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 391 | 9 | 0 | 4 | 5.3 | C=CCc1c(C(=O)c2c(C)cc(C)cc2C)nc(C)nc1N(CCC)CC1CC1 | 10.1016/j.bmcl.2004.05.072 | |||
| 176157 | 9515 | 28 | None | -9 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1016/s0960-894x(00)00661-2 | |||
| 3512 | 9515 | 28 | None | -9 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1016/s0960-894x(00)00661-2 | |||
| CHEMBL45281 | 9515 | 28 | None | -9 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 10.1016/s0960-894x(00)00661-2 | |||
| 21916078 | 14450 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 420 | 6 | 0 | 4 | 5.6 | CCN(Cc1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C)CC1CC1 | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1088625 | 14450 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 420 | 6 | 0 | 4 | 5.6 | CCN(Cc1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C)CC1CC1 | 10.1016/j.bmcl.2010.01.127 | |||
| 44386496 | 69352 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 499 | 10 | 0 | 6 | 6.4 | CCCCN(CC)c1nc(C)nc2c1nc(OCC1CC1)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL178272 | 69352 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 499 | 10 | 0 | 6 | 6.4 | CCCCN(CC)c1nc(C)nc2c1nc(OCC1CC1)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 10648379 | 65851 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 479 | 10 | 0 | 9 | 3.0 | COCCN(CCOC)c1nc(C)nc2c1ncn2-c1c(Br)cc(OC)cc1OC | 10.1021/jm980224g | |||
| CHEMBL169571 | 65851 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 479 | 10 | 0 | 9 | 3.0 | COCCN(CCOC)c1nc(C)nc2c1ncn2-c1c(Br)cc(OC)cc1OC | 10.1021/jm980224g | |||
| 11501973 | 103621 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 4 | 0 | 4 | 5.7 | CCCN1c2cc(C)nc3c(-c4ccc(Cl)cc4Cl)nn(c23)C[C@@H]1CC | 10.1021/jm049085v | |||
| CHEMBL265282 | 103621 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 4 | 0 | 4 | 5.7 | CCCN1c2cc(C)nc3c(-c4ccc(Cl)cc4Cl)nn(c23)C[C@@H]1CC | 10.1021/jm049085v | |||
| 22324325 | 212652 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 373 | 9 | 0 | 6 | 3.9 | CCCN(CCC)c1c(C)nc(-c2c(OC)cccc2OC)n(CC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL83789 | 212652 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 373 | 9 | 0 | 6 | 3.9 | CCCN(CCC)c1c(C)nc(-c2c(OC)cccc2OC)n(CC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 21916104 | 13190 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 426 | 6 | 0 | 4 | 6.0 | CCCCN(C)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1082368 | 13190 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 426 | 6 | 0 | 4 | 6.0 | CCCCN(C)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 16416344 | 210157 | 14 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 376 | 2 | 0 | 5 | 4.2 | Cc1cc(N2CCOCC2)n2nc(C)c(-c3ccc(Cl)cc3Cl)c2n1 | 10.1016/s0960-894x(98)00372-2 | |||
| CHEMBL65308 | 210157 | 14 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 376 | 2 | 0 | 5 | 4.2 | Cc1cc(N2CCOCC2)n2nc(C)c(-c3ccc(Cl)cc3Cl)c2n1 | 10.1016/s0960-894x(98)00372-2 | |||
| 44337472 | 115728 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 366 | 8 | 0 | 4 | 5.3 | CCCN(c1nc(-c2c(C)cc(C)cc2C)n(CC)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL321155 | 115728 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 366 | 8 | 0 | 4 | 5.3 | CCCN(c1nc(-c2c(C)cc(C)cc2C)n(CC)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| 10228046 | 28211 | 0 | None | - | 1 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 485 | 7 | 1 | 4 | 7.1 | CCCN(CC1CC1)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL131530 | 28211 | 0 | None | - | 1 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 485 | 7 | 1 | 4 | 7.1 | CCCN(CC1CC1)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2003.08.055 | |||
| 44460259 | 212414 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | Cc1ccccc1[C@H](Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| CHEMBL81760 | 212414 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | Cc1ccccc1[C@H](Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| 9828535 | 172340 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 437 | 6 | 0 | 8 | 3.0 | CCN(c1nc(C)nc(N2CCOCC2)n1)c1c(Br)cc(OC)cc1OC | 10.1021/jm980222w | |||
| CHEMBL424204 | 172340 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 437 | 6 | 0 | 8 | 3.0 | CCN(c1nc(C)nc(N2CCOCC2)n1)c1c(Br)cc(OC)cc1OC | 10.1021/jm980222w | |||
| CHEMBL43216 | 172340 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 437 | 6 | 0 | 8 | 3.0 | CCN(c1nc(C)nc(N2CCOCC2)n1)c1c(Br)cc(OC)cc1OC | 10.1021/jm980222w | |||
| 44341728 | 16755 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 396 | 7 | 0 | 4 | 6.0 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(C)cc3Cl)n(CC)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL114821 | 16755 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 396 | 7 | 0 | 4 | 6.0 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(C)cc3Cl)n(CC)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 44341763 | 170213 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 404 | 7 | 0 | 4 | 6.4 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(CC)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL419761 | 170213 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 404 | 7 | 0 | 4 | 6.4 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(CC)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 9821153 | 16248 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 378 | 5 | 0 | 5 | 4.3 | COCCN(C)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL111960 | 16248 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 378 | 5 | 0 | 5 | 4.3 | COCCN(C)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 21916241 | 13261 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 456 | 8 | 0 | 5 | 5.6 | CCCN(CCOC)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1082685 | 13261 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 456 | 8 | 0 | 5 | 5.6 | CCCN(CCOC)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 11225236 | 148148 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 472 | 7 | 1 | 5 | 6.5 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCc3ccccc3)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL383773 | 148148 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 472 | 7 | 1 | 5 | 6.5 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCc3ccccc3)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| 21916145 | 14272 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 434 | 7 | 0 | 4 | 6.0 | CCCN(Cc1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C)CC1CC1 | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1087164 | 14272 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 434 | 7 | 0 | 4 | 6.0 | CCCN(Cc1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C)CC1CC1 | 10.1016/j.bmcl.2010.01.127 | |||
| 44446742 | 101454 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 489 | 10 | 1 | 5 | 6.3 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OCCN2CCCC(O)C2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL252688 | 101454 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 489 | 10 | 1 | 5 | 6.3 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OCCN2CCCC(O)C2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 9828535 | 172340 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 437 | 6 | 0 | 8 | 3.0 | CCN(c1nc(C)nc(N2CCOCC2)n1)c1c(Br)cc(OC)cc1OC | 10.1021/jm990590f | |||
| CHEMBL424204 | 172340 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 437 | 6 | 0 | 8 | 3.0 | CCN(c1nc(C)nc(N2CCOCC2)n1)c1c(Br)cc(OC)cc1OC | 10.1021/jm990590f | |||
| CHEMBL43216 | 172340 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 437 | 6 | 0 | 8 | 3.0 | CCN(c1nc(C)nc(N2CCOCC2)n1)c1c(Br)cc(OC)cc1OC | 10.1021/jm990590f | |||
| 10671608 | 65531 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 458 | 9 | 0 | 6 | 5.8 | CCCCN(CCCC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL168646 | 65531 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 458 | 9 | 0 | 6 | 5.8 | CCCCN(CCCC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 11247120 | 17063 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 418 | 8 | 0 | 4 | 6.7 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL116167 | 17063 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 418 | 8 | 0 | 4 | 6.7 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 44341738 | 16813 | 1 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 332 | 6 | 0 | 2 | 6.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(C)cc3)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL115154 | 16813 | 1 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 332 | 6 | 0 | 2 | 6.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(C)cc3)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 44341729 | 17178 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 7.1 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(CC)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL116280 | 17178 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 7.1 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(CC)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 46891011 | 13209 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 438 | 3 | 0 | 4 | 6.0 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCC(C)CC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1082444 | 13209 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 438 | 3 | 0 | 4 | 6.0 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCC(C)CC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 20780059 | 173381 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 458 | 6 | 0 | 6 | 5.3 | Cc1cc(C)c(-n2c3ncccc3n3c(CN(C)CCc4ccncc4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL428044 | 173381 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 458 | 6 | 0 | 6 | 5.3 | Cc1cc(C)c(-n2c3ncccc3n3c(CN(C)CCc4ccncc4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| 44337516 | 14359 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 338 | 7 | 1 | 3 | 4.8 | CCCN(c1n[nH]c(-c2c(C)cc(C)cc2C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL108784 | 14359 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 338 | 7 | 1 | 3 | 4.8 | CCCN(c1n[nH]c(-c2c(C)cc(C)cc2C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| 44317667 | 111190 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 406 | 8 | 1 | 3 | 6.5 | Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2C(C)C)c(Cl)c1 | 10.1021/jm049974i | |||
| CHEMBL310343 | 111190 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 406 | 8 | 1 | 3 | 6.5 | Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2C(C)C)c(Cl)c1 | 10.1021/jm049974i | |||
| 10572455 | 64464 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 389 | 7 | 1 | 5 | 4.8 | C=CCNc1nc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL166897 | 64464 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 389 | 7 | 1 | 5 | 4.8 | C=CCNc1nc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 20780009 | 13398 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 466 | 6 | 0 | 4 | 6.0 | CCCN(CC1CC1)C(=O)c1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083299 | 13398 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 466 | 6 | 0 | 4 | 6.0 | CCCN(CC1CC1)C(=O)c1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 44587490 | 194899 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 361 | 7 | 0 | 4 | 5.4 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)nc1Cl | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL498319 | 194899 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 361 | 7 | 0 | 4 | 5.4 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)nc1Cl | 10.1016/j.bmcl.2008.07.063 | |||
| 44337293 | 12083 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 344 | 7 | 0 | 4 | 4.5 | CCCN(c1nc(-c2ccc(Cl)cc2)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL106728 | 12083 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 344 | 7 | 0 | 4 | 4.5 | CCCN(c1nc(-c2ccc(Cl)cc2)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| 10791657 | 65499 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 504 | 9 | 0 | 9 | 3.3 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(OC(F)(F)F)cc1Br | 10.1021/jm980224g | |||
| CHEMBL168536 | 65499 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 504 | 9 | 0 | 9 | 3.3 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(OC(F)(F)F)cc1Br | 10.1021/jm980224g | |||
| 10765120 | 65037 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 430 | 7 | 0 | 7 | 4.1 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1ccc(C(C)=O)cc1Br | 10.1021/jm980224g | |||
| CHEMBL168252 | 65037 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 430 | 7 | 0 | 7 | 4.1 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1ccc(C(C)=O)cc1Br | 10.1021/jm980224g | |||
| 44460600 | 111904 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 412 | 8 | 1 | 3 | 6.3 | CCc1ccccc1C(Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| CHEMBL311431 | 111904 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 412 | 8 | 1 | 3 | 6.3 | CCc1ccccc1C(Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| 46881383 | 13936 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 408 | 6 | 0 | 4 | 5.3 | CCCN(CC1CCC1)C(=O)c1c(C)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1085431 | 13936 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 408 | 6 | 0 | 4 | 5.3 | CCCN(CC1CCC1)C(=O)c1c(C)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| 10640801 | 65556 | 1 | None | - | 1 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 339 | 2 | 0 | 3 | 3.5 | Cc1cc(C)nc(N(C)c2ccc(I)cc2)n1 | 10.1021/jm980222w | |||
| CHEMBL168764 | 65556 | 1 | None | - | 1 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 339 | 2 | 0 | 3 | 3.5 | Cc1cc(C)nc(N(C)c2ccc(I)cc2)n1 | 10.1021/jm980222w | |||
| 44397565 | 129414 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 580 | 9 | 0 | 4 | 8.5 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCc4ccccc4)CCc4ccccc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL360389 | 129414 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 580 | 9 | 0 | 4 | 8.5 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCc4ccccc4)CCc4ccccc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| 44318056 | 212029 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2Cl)c(Cl)c1 | 10.1021/jm049974i | |||
| CHEMBL78884 | 212029 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2Cl)c(Cl)c1 | 10.1021/jm049974i | |||
| 44443609 | 100930 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 420 | 10 | 1 | 6 | 5.7 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1NC(COC(C)C)c1ccccc1 | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL249430 | 100930 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 420 | 10 | 1 | 6 | 5.7 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1NC(COC(C)C)c1ccccc1 | 10.1016/j.bmcl.2007.09.008 | |||
| 44460599 | 174901 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 6.4 | Cc1cccc(C)c1C(Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| CHEMBL432928 | 174901 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 6.4 | Cc1cccc(C)c1C(Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| 44443578 | 161628 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 327 | 8 | 2 | 5 | 4.6 | CCc1nc(NC(CC)CC)c(CC)nc1Nc1cccc(C)n1 | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL400531 | 161628 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 327 | 8 | 2 | 5 | 4.6 | CCc1nc(NC(CC)CC)c(CC)nc1Nc1cccc(C)n1 | 10.1016/j.bmcl.2007.09.008 | |||
| 20780184 | 73871 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 504 | 7 | 0 | 4 | 7.3 | CCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL187362 | 73871 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 504 | 7 | 0 | 4 | 7.3 | CCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 20780065 | 173154 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 558 | 7 | 0 | 4 | 7.6 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CC4CC4)CC(F)(F)C(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL427527 | 173154 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 558 | 7 | 0 | 4 | 7.6 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CC4CC4)CC(F)(F)C(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| 44341855 | 121586 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 467 | 8 | 0 | 5 | 6.5 | CCCCN(CCc1ccncc1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL334061 | 121586 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 467 | 8 | 0 | 5 | 6.5 | CCCCN(CCc1ccncc1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 10502734 | 127224 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 429 | 3 | 0 | 3 | 6.8 | Cc1cc(-c2ccccc2)c2c(C#N)cn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| CHEMBL353916 | 127224 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 429 | 3 | 0 | 3 | 6.8 | Cc1cc(-c2ccccc2)c2c(C#N)cn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| 20780265 | 13321 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 560 | 7 | 0 | 4 | 7.8 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCC(F)(F)F)Cc4ccc(F)cc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1082963 | 13321 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 560 | 7 | 0 | 4 | 7.8 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCC(F)(F)F)Cc4ccc(F)cc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 11307122 | 80432 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 532 | 9 | 1 | 7 | 6.5 | COc1cc(COc2ccc(S(=O)(=O)c3ccc(C)nc3Nc3c(C)cc(C)cc3C)cc2)cc(OC)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL201798 | 80432 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 532 | 9 | 1 | 7 | 6.5 | COc1cc(COc2ccc(S(=O)(=O)c3ccc(C)nc3Nc3c(C)cc(C)cc3C)cc2)cc(OC)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| 44341861 | 16372 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 384 | 8 | 0 | 4 | 6.0 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL112549 | 16372 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 384 | 8 | 0 | 4 | 6.0 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 20780288 | 12361 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 406 | 6 | 0 | 4 | 4.9 | Cc1cc(C)c(N2CCCn3c2nc(C)c3C(=O)N(CC2CC2)CC2CC2)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1077158 | 12361 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 406 | 6 | 0 | 4 | 4.9 | Cc1cc(C)c(N2CCCn3c2nc(C)c3C(=O)N(CC2CC2)CC2CC2)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| 44337533 | 174648 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 326 | 6 | 0 | 4 | 4.4 | CCCN(CCC)c1nc(-c2ccc(Cl)cc2Cl)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL431067 | 174648 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 326 | 6 | 0 | 4 | 4.4 | CCCN(CCC)c1nc(-c2ccc(Cl)cc2Cl)n(C)n1 | 10.1021/jm049339c | |||
| 44337577 | 12116 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 390 | 6 | 0 | 5 | 5.3 | CCCN(c1nc(-c2ccc(Cl)cc2Cl)n(C)n1)c1ccccc1OC | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL106874 | 12116 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 390 | 6 | 0 | 5 | 5.3 | CCCN(c1nc(-c2ccc(Cl)cc2Cl)n(C)n1)c1ccccc1OC | 10.1016/s0960-894x(01)00657-6 | |||
| 44386313 | 127604 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 514 | 8 | 0 | 7 | 5.5 | CCCCN(CC)c1nc(C)nc2c1nc(N1CCOCC1)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL355803 | 127604 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 514 | 8 | 0 | 7 | 5.5 | CCCCN(CC)c1nc(C)nc2c1nc(N1CCOCC1)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 10550837 | 64602 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 434 | 7 | 2 | 8 | 2.2 | Cc1nc(N(CCO)CCO)c2nnn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980224g | |||
| CHEMBL167024 | 64602 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 434 | 7 | 2 | 8 | 2.2 | Cc1nc(N(CCO)CCO)c2nnn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980224g | |||
| 10041172 | 169242 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 311 | 4 | 2 | 3 | 3.6 | C#Cc1cccc(/N=C(/NNc2ccccc2Cl)C(C)=O)c1 | 10.1021/jm025512y | |||
| CHEMBL416693 | 169242 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 311 | 4 | 2 | 3 | 3.6 | C#Cc1cccc(/N=C(/NNc2ccccc2Cl)C(C)=O)c1 | 10.1021/jm025512y | |||
| 10688248 | 65583 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 335 | 4 | 0 | 4 | 4.0 | CCN(c1nc(C)cc(C)n1)c1ccc(OC)cc1Br | 10.1021/jm980222w | |||
| CHEMBL168824 | 65583 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 335 | 4 | 0 | 4 | 4.0 | CCN(c1nc(C)cc(C)n1)c1ccc(OC)cc1Br | 10.1021/jm980222w | |||
| 44341697 | 16718 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL114649 | 16718 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 10319873 | 101040 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 5.2 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2cc(C)ccn2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL250282 | 101040 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 5.2 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2cc(C)ccn2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| 21916156 | 13667 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 506 | 7 | 0 | 4 | 7.3 | CCCN(Cc1ccc(F)cc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1084297 | 13667 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 506 | 7 | 0 | 4 | 7.3 | CCCN(Cc1ccc(F)cc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 21916243 | 13738 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 474 | 6 | 0 | 4 | 6.7 | CCN(Cc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1084564 | 13738 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 474 | 6 | 0 | 4 | 6.7 | CCN(Cc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 21916231 | 14183 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 542 | 7 | 0 | 4 | 7.3 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCc4ccccc4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1086522 | 14183 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 542 | 7 | 0 | 4 | 7.3 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCc4ccccc4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 11395654 | 85102 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 406 | 10 | 0 | 5 | 5.9 | CCCC[C@H](c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL2094064 | 85102 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 406 | 10 | 0 | 5 | 5.9 | CCCC[C@H](c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL2109726 | 85102 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 406 | 10 | 0 | 5 | 5.9 | CCCC[C@H](c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| 44352370 | 25655 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 455 | 8 | 1 | 4 | 7.0 | CCCN(Cc1oc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL128310 | 25655 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 455 | 8 | 1 | 4 | 7.0 | CCCN(Cc1oc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 18691315 | 105019 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 453 | 6 | 1 | 4 | 6.2 | CCN(c1nc(C)cc(-c2ccccc2C(=O)O)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL274439 | 105019 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 453 | 6 | 1 | 4 | 6.2 | CCN(c1nc(C)cc(-c2ccccc2C(=O)O)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 10268909 | 200335 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 341 | 7 | 0 | 4 | 5.0 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2C)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL526829 | 200335 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 341 | 7 | 0 | 4 | 5.0 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2C)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| 20780126 | 175030 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 482 | 6 | 0 | 4 | 6.5 | CCCN(CC1CC1)C(=O)c1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL433763 | 175030 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 482 | 6 | 0 | 4 | 6.5 | CCCN(CC1CC1)C(=O)c1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 10686839 | 64918 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 315 | 5 | 0 | 4 | 5.1 | CCN(c1nc(C)cc(C)n1)c1ccc(C(C)C)cc1SC | 10.1021/jm980222w | |||
| CHEMBL167871 | 64918 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 315 | 5 | 0 | 4 | 5.1 | CCN(c1nc(C)cc(C)n1)c1ccc(C(C)C)cc1SC | 10.1021/jm980222w | |||
| 10787443 | 65809 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 404 | 3 | 0 | 2 | 6.9 | Cc1cc(-c2ccccc2)c2ccn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| CHEMBL169359 | 65809 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 404 | 3 | 0 | 2 | 6.9 | Cc1cc(-c2ccccc2)c2ccn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| 20780122 | 100615 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 423 | 7 | 0 | 5 | 5.9 | CCCCN(CC)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL247755 | 100615 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 423 | 7 | 0 | 5 | 5.9 | CCCCN(CC)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 20780177 | 153782 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 421 | 6 | 0 | 5 | 5.5 | CCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12)CC1CC1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL392654 | 153782 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 421 | 6 | 0 | 5 | 5.5 | CCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12)CC1CC1 | 10.1016/j.bmcl.2007.01.008 | |||
| 44446722 | 101580 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 376 | 8 | 0 | 3 | 6.4 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2CC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL253491 | 101580 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 376 | 8 | 0 | 3 | 6.4 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2CC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL2372911 | 217091 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm034180+ | |||||
| 10838946 | 65838 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 494 | 8 | 1 | 7 | 5.1 | COCC(Cc1ccccc1)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169528 | 65838 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 494 | 8 | 1 | 7 | 5.1 | COCC(Cc1ccccc1)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 12967647 | 25713 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 431 | 7 | 1 | 4 | 6.4 | CCCN(CC1CC1)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL128625 | 25713 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 431 | 7 | 1 | 4 | 6.4 | CCCN(CC1CC1)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C | 10.1016/j.bmcl.2003.08.055 | |||
| 20780124 | 74187 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 428 | 6 | 0 | 4 | 5.8 | CCCN(CC1CC1)C(=O)c1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL188849 | 74187 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 428 | 6 | 0 | 4 | 5.8 | CCCN(CC1CC1)C(=O)c1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 44392802 | 128957 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 395 | 10 | 1 | 4 | 5.2 | CCCN(CC1CC1)c1cc(C(O)c2c(CC)cc(CC)cc2CC)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL359745 | 128957 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 395 | 10 | 1 | 4 | 5.2 | CCCN(CC1CC1)c1cc(C(O)c2c(CC)cc(CC)cc2CC)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| 20780186 | 100647 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 395 | 5 | 0 | 5 | 5.1 | CCN(CC)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL247957 | 100647 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 395 | 5 | 0 | 5 | 5.1 | CCN(CC)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 20780149 | 74080 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 482 | 8 | 0 | 4 | 7.2 | CCCN(CCC1CC1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL188358 | 74080 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 482 | 8 | 0 | 4 | 7.2 | CCCN(CCC1CC1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 10737736 | 65519 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 367 | 2 | 0 | 3 | 5.4 | Cc1cc(C)c2c(C#N)cn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| CHEMBL168590 | 65519 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 367 | 2 | 0 | 3 | 5.4 | Cc1cc(C)c2c(C#N)cn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| 21916261 | 14276 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 404 | 3 | 0 | 4 | 5.1 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN2CC=CCC2)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1087172 | 14276 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 404 | 3 | 0 | 4 | 5.1 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN2CC=CCC2)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| 10545026 | 64664 | 1 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 339 | 2 | 0 | 3 | 3.5 | Cc1cc(C)nc(N(C)c2ccccc2I)n1 | 10.1021/jm980222w | |||
| CHEMBL167217 | 64664 | 1 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 339 | 2 | 0 | 3 | 3.5 | Cc1cc(C)nc(N(C)c2ccccc2I)n1 | 10.1021/jm980222w | |||
| 53309547 | 70771 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 393 | 9 | 1 | 3 | 7.0 | CCCCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1807037 | 70771 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 393 | 9 | 1 | 3 | 7.0 | CCCCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 15490819 | 104925 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 438 | 6 | 1 | 4 | 6.5 | CCN(c1nc(C)cc(-c2ccccc2NC)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL273745 | 104925 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 438 | 6 | 1 | 4 | 6.5 | CCN(c1nc(C)cc(-c2ccccc2NC)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 44341718 | 104159 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 446 | 9 | 0 | 4 | 7.7 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C(C)C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL269690 | 104159 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 446 | 9 | 0 | 4 | 7.7 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C(C)C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 10165732 | 71084 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 537 | 9 | 1 | 5 | 8.3 | CCCN(Cc1ccc(OC)cc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181084 | 71084 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 537 | 9 | 1 | 5 | 8.3 | CCCN(Cc1ccc(OC)cc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 20780140 | 130842 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 494 | 7 | 0 | 4 | 7.2 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3ccc(Cl)cc3Cl)c3ccccc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL363218 | 130842 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 494 | 7 | 0 | 4 | 7.2 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3ccc(Cl)cc3Cl)c3ccccc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| 44460572 | 111539 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | Cc1ccccc1C(Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| CHEMBL310773 | 111539 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | Cc1ccccc1C(Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| 22324329 | 110914 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 373 | 9 | 0 | 6 | 3.9 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2OC)n(CC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL309440 | 110914 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 373 | 9 | 0 | 6 | 3.9 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2OC)n(CC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 11122528 | 72002 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 413 | 10 | 0 | 7 | 4.0 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2c(OC)cc(OC)cc2OC)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL182643 | 72002 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 413 | 10 | 0 | 7 | 4.0 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2c(OC)cc(OC)cc2OC)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 44392773 | 73431 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 349 | 7 | 0 | 4 | 4.4 | C=CCN(CC=C)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL185329 | 73431 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 349 | 7 | 0 | 4 | 4.4 | C=CCN(CC=C)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 10786842 | 64294 | 1 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 395 | 4 | 0 | 3 | 5.0 | CCN(c1nc(C)cc(C)n1)c1ccc(C(C)C)cc1I | 10.1021/jm980223o | |||
| CHEMBL166162 | 64294 | 1 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 395 | 4 | 0 | 3 | 5.0 | CCN(c1nc(C)cc(C)n1)c1ccc(C(C)C)cc1I | 10.1021/jm980223o | |||
| 10786842 | 64294 | 1 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 395 | 4 | 0 | 3 | 5.0 | CCN(c1nc(C)cc(C)n1)c1ccc(C(C)C)cc1I | 10.1021/jm980222w | |||
| CHEMBL166162 | 64294 | 1 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 395 | 4 | 0 | 3 | 5.0 | CCN(c1nc(C)cc(C)n1)c1ccc(C(C)C)cc1I | 10.1021/jm980222w | |||
| 44308172 | 169466 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 377 | 6 | 1 | 5 | 5.2 | CCCCCNc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL417039 | 169466 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 377 | 6 | 1 | 5 | 5.2 | CCCCCNc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 21916214 | 14352 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 524 | 7 | 0 | 4 | 7.0 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN(CCc2ccccc2)CC(F)(F)F)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1087803 | 14352 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 524 | 7 | 0 | 4 | 7.0 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN(CCc2ccccc2)CC(F)(F)F)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| 10301060 | 71639 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 8.3 | CCCN(Cc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL182133 | 71639 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 8.3 | CCCN(Cc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 10527943 | 65821 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 459 | 8 | 1 | 7 | 4.5 | CCCC(CN(C)C)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169421 | 65821 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 459 | 8 | 1 | 7 | 4.5 | CCCC(CN(C)C)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44392747 | 73095 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 367 | 5 | 0 | 5 | 3.9 | COC[C@@H]1CCCN1c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL184963 | 73095 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 367 | 5 | 0 | 5 | 3.9 | COC[C@@H]1CCCN1c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 44341857 | 117197 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 459 | 7 | 0 | 5 | 6.0 | CCCCN(CC1CCCN1C)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL324497 | 117197 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 459 | 7 | 0 | 5 | 6.0 | CCCCN(CC1CCCN1C)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 44443593 | 101108 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 406 | 10 | 1 | 6 | 5.3 | CCOCC(Nc1nc(CC)c(Oc2cc(C)ccn2)nc1CC)c1ccccc1 | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL250618 | 101108 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 406 | 10 | 1 | 6 | 5.3 | CCOCC(Nc1nc(CC)c(Oc2cc(C)ccn2)nc1CC)c1ccccc1 | 10.1016/j.bmcl.2007.09.008 | |||
| 11727011 | 210482 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 321 | 4 | 2 | 3 | 4.2 | CC(=O)/C(=N\c1ccc(Cl)cc1)NNc1ccccc1Cl | 10.1021/jm025512y | |||
| CHEMBL67570 | 210482 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 321 | 4 | 2 | 3 | 4.2 | CC(=O)/C(=N\c1ccc(Cl)cc1)NNc1ccccc1Cl | 10.1021/jm025512y | |||
| 44317976 | 111541 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 415 | 6 | 2 | 4 | 6.1 | COc1ccc(C(=O)C(Nc2ccc(Cl)cc2Cl)c2ccccc2C)cc1O | 10.1021/jm049974i | |||
| CHEMBL310783 | 111541 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 415 | 6 | 2 | 4 | 6.1 | COc1ccc(C(=O)C(Nc2ccc(Cl)cc2Cl)c2ccccc2C)cc1O | 10.1021/jm049974i | |||
| 44318168 | 212794 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 389 | 9 | 0 | 5 | 4.4 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)n(CCF)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL84974 | 212794 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 389 | 9 | 0 | 5 | 4.4 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)n(CCF)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 11235365 | 73059 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 414 | 7 | 0 | 6 | 5.1 | CCCN(CCC)c1c(Cl)c(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL184740 | 73059 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 414 | 7 | 0 | 6 | 5.1 | CCCN(CCC)c1c(Cl)c(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 10672294 | 65878 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 477 | 10 | 0 | 8 | 4.2 | CCOCC(COCC)Oc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169751 | 65878 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 477 | 10 | 0 | 8 | 4.2 | CCOCC(COCC)Oc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 10166079 | 129891 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 547 | 7 | 1 | 4 | 8.4 | FC(F)(F)CN(Cc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL361108 | 129891 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 547 | 7 | 1 | 4 | 8.4 | FC(F)(F)CN(Cc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 10833915 | 127523 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 384 | 9 | 0 | 8 | 2.7 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1 | 10.1021/jm980224g | |||
| CHEMBL355008 | 127523 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 384 | 9 | 0 | 8 | 2.7 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1 | 10.1021/jm980224g | |||
| 11282674 | 80692 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 463 | 9 | 1 | 6 | 6.0 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCCCCC#N)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL201982 | 80692 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 463 | 9 | 1 | 6 | 6.0 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCCCCC#N)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| 11677548 | 141956 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 374 | 3 | 0 | 4 | 5.2 | Cc1cc2c3c(n1)c(-c1ccc(Cl)cc1Cl)nn3CCN2CC(C)C | 10.1021/jm049085v | |||
| CHEMBL371981 | 141956 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 374 | 3 | 0 | 4 | 5.2 | Cc1cc2c3c(n1)c(-c1ccc(Cl)cc1Cl)nn3CCN2CC(C)C | 10.1021/jm049085v | |||
| 44443580 | 100886 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 353 | 6 | 2 | 5 | 5.1 | CCC(CC)Nc1nc(C)c(Nc2ncc(Cl)cc2Cl)nc1C | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL249191 | 100886 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 353 | 6 | 2 | 5 | 5.1 | CCC(CC)Nc1nc(C)c(Nc2ncc(Cl)cc2Cl)nc1C | 10.1016/j.bmcl.2007.09.008 | |||
| 44318106 | 112910 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 385 | 9 | 0 | 5 | 4.7 | CCCN(CCC)c1c(CC)nc(-c2c(C)cc(C)cc2OC)n(CC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL313479 | 112910 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 385 | 9 | 0 | 5 | 4.7 | CCCN(CCC)c1c(CC)nc(-c2c(C)cc(C)cc2OC)n(CC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 10790606 | 64872 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 471 | 9 | 0 | 6 | 5.2 | C=CCN(CC=C)c1nc(C)nc(N(CC)c2ccc(OC(F)(F)F)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL167463 | 64872 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 471 | 9 | 0 | 6 | 5.2 | C=CCN(CC=C)c1nc(C)nc(N(CC)c2ccc(OC(F)(F)F)cc2Br)n1 | 10.1021/jm980222w | |||
| 10741479 | 65600 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 433 | 9 | 0 | 5 | 5.9 | CCCN(CCC)c1nc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL168844 | 65600 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 433 | 9 | 0 | 5 | 5.9 | CCCN(CCC)c1nc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 10502738 | 172484 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 429 | 9 | 0 | 5 | 5.4 | C=CCN(CC=C)c1nc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL424555 | 172484 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 429 | 9 | 0 | 5 | 5.4 | C=CCN(CC=C)c1nc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 10808915 | 127591 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 366 | 7 | 1 | 6 | 4.8 | CCCC(CCC)Nc1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL355689 | 127591 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 366 | 7 | 1 | 6 | 4.8 | CCCC(CCC)Nc1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| 44341815 | 16230 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 448 | 10 | 0 | 5 | 6.3 | CCCCCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL111838 | 16230 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 448 | 10 | 0 | 5 | 6.3 | CCCCCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 11417694 | 74227 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 382 | 7 | 1 | 5 | 4.4 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)cc1C | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL189089 | 74227 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 382 | 7 | 1 | 5 | 4.4 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(OC)cc1C | 10.1016/j.bmcl.2015.10.010 | |||
| 44307724 | 108956 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 371 | 6 | 0 | 5 | 4.9 | CCCN(CCC)c1nc(C)nc2c(-c3ccc(Cl)cc3C)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL302742 | 108956 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 371 | 6 | 0 | 5 | 4.9 | CCCN(CCC)c1nc(C)nc2c(-c3ccc(Cl)cc3C)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 11178741 | 113159 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 426 | 10 | 0 | 5 | 6.3 | CCCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL3085414 | 113159 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 426 | 10 | 0 | 5 | 6.3 | CCCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL3139324 | 113159 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 426 | 10 | 0 | 5 | 6.3 | CCCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 9868427 | 70614 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 450 | 5 | 0 | 6 | 6.3 | CCN(CC)c1nc(C)nc2c1sc(=S)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00159-6 | |||
| CHEMBL18029 | 70614 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 450 | 5 | 0 | 6 | 6.3 | CCN(CC)c1nc(C)nc2c1sc(=S)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00159-6 | |||
| 9956594 | 104900 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 474 | 7 | 0 | 6 | 5.7 | CCCN(CC1CC1)c1nc(C)nc2c1sc(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00159-6 | |||
| CHEMBL273559 | 104900 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 474 | 7 | 0 | 6 | 5.7 | CCCN(CC1CC1)c1nc(C)nc2c1sc(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00159-6 | |||
| 44341491 | 16262 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 376 | 5 | 0 | 4 | 5.5 | CCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL112031 | 16262 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 376 | 5 | 0 | 4 | 5.5 | CCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 9868427 | 70614 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 450 | 5 | 0 | 6 | 6.3 | CCN(CC)c1nc(C)nc2c1sc(=S)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm990590f | |||
| CHEMBL18029 | 70614 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 450 | 5 | 0 | 6 | 6.3 | CCN(CC)c1nc(C)nc2c1sc(=S)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm990590f | |||
| 22249094 | 70714 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 365 | 7 | 1 | 3 | 6.2 | CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1806728 | 70714 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 365 | 7 | 1 | 3 | 6.2 | CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 10223332 | 70722 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 411 | 9 | 1 | 5 | 5.8 | CCc1nc(-c2ccc(OC)cc2OC(F)(F)F)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1806736 | 70722 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 411 | 9 | 1 | 5 | 5.8 | CCc1nc(-c2ccc(OC)cc2OC(F)(F)F)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 9801390 | 116512 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 404 | 7 | 0 | 4 | 6.4 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(CC)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL322969 | 116512 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 404 | 7 | 0 | 4 | 6.4 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(CC)c12 | 10.1016/s0960-894x(03)00621-8 | |||
| 46871760 | 13582 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 472 | 7 | 0 | 4 | 6.7 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3Cl)c(Cl)cn12)CC1CC1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083921 | 13582 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 472 | 7 | 0 | 4 | 6.7 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3Cl)c(Cl)cn12)CC1CC1 | 10.1016/j.bmcl.2010.04.094 | |||
| 122193717 | 130734 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 472 | 6 | 1 | 4 | 6.2 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)(C)C)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628734 | 130734 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 472 | 6 | 1 | 4 | 6.2 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C(C)(C)C)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| 53310133 | 70718 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 385 | 10 | 1 | 5 | 5.7 | CCc1nc(-c2ccc(OC(C)C)cc2OC)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1806732 | 70718 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 385 | 10 | 1 | 5 | 5.7 | CCc1nc(-c2ccc(OC(C)C)cc2OC)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 9951076 | 74185 | 2 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 366 | 7 | 0 | 6 | 4.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(N(C)C)nc3)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL188844 | 74185 | 2 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 366 | 7 | 0 | 6 | 4.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(N(C)C)nc3)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL2165204 | 74185 | 2 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 366 | 7 | 0 | 6 | 4.1 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(N(C)C)nc3)c(C)nn12 | 10.1021/jm040058e | |||
| 11177298 | 129760 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 408 | 9 | 0 | 6 | 5.2 | CCCCN(CCCC)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL360851 | 129760 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 408 | 9 | 0 | 6 | 5.2 | CCCCN(CCCC)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 11224781 | 131301 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 415 | 6 | 0 | 3 | 7.0 | CCCC(CCC)N1CCc2cn(-c3ccc(Cl)cc3Cl)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL364016 | 131301 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 415 | 6 | 0 | 3 | 7.0 | CCCC(CCC)N1CCc2cn(-c3ccc(Cl)cc3Cl)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 10717500 | 127029 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 429 | 7 | 0 | 5 | 5.6 | CCCCN(CC)c1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL352340 | 127029 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 429 | 7 | 0 | 5 | 5.6 | CCCCN(CC)c1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 10551312 | 127197 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 444 | 8 | 0 | 7 | 4.0 | C=CCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL353732 | 127197 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 444 | 8 | 0 | 7 | 4.0 | C=CCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 22249116 | 70775 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 353 | 6 | 1 | 4 | 5.4 | CCC(CC)Nc1nc(C)c(-c2ccc(Cl)cc2Cl)nc1OC | 10.1021/jm200365y | |||
| CHEMBL1807041 | 70775 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 353 | 6 | 1 | 4 | 5.4 | CCC(CC)Nc1nc(C)c(-c2ccc(Cl)cc2Cl)nc1OC | 10.1021/jm200365y | |||
| 44384802 | 66709 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 381 | 6 | 0 | 6 | 4.0 | CCCCN(CC)c1nc(C)nc2c1n(C)c(=O)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL173196 | 66709 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 381 | 6 | 0 | 6 | 4.0 | CCCCN(CC)c1nc(C)nc2c1n(C)c(=O)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00108-0 | |||
| 9931098 | 65541 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 404 | 8 | 0 | 8 | 3.8 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1c(Cl)cc(OC)cc1OC | 10.1021/jm980224g | |||
| CHEMBL168676 | 65541 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 404 | 8 | 0 | 8 | 3.8 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1c(Cl)cc(OC)cc1OC | 10.1021/jm980224g | |||
| 10717499 | 136177 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 6.0 | CCCC(CC)Nc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL367110 | 136177 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 6.0 | CCCC(CC)Nc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 9908466 | 121582 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL334039 | 121582 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 44341739 | 120278 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 392 | 6 | 1 | 5 | 4.5 | CCCN(CCO)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL332040 | 120278 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 392 | 6 | 1 | 5 | 4.5 | CCCN(CCO)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 44341737 | 120872 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 388 | 5 | 0 | 4 | 5.5 | CCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL332721 | 120872 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 388 | 5 | 0 | 4 | 5.5 | CCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 46872038 | 130735 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 430 | 6 | 1 | 4 | 5.2 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Br)cc1C | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628735 | 130735 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 430 | 6 | 1 | 4 | 5.2 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Br)cc1C | 10.1016/j.bmcl.2015.10.010 | |||
| 46872037 | 130736 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 430 | 6 | 1 | 4 | 5.2 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628736 | 130736 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 430 | 6 | 1 | 4 | 5.2 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| 122193718 | 130737 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 386 | 6 | 1 | 4 | 5.1 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C)cc1Cl | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628737 | 130737 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 386 | 6 | 1 | 4 | 5.1 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(C)cc1Cl | 10.1016/j.bmcl.2015.10.010 | |||
| 10200724 | 70749 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 395 | 8 | 1 | 4 | 5.9 | CCc1nc(-c2ccc(OC)cc2C(F)(F)F)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1806956 | 70749 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 395 | 8 | 1 | 4 | 5.9 | CCc1nc(-c2ccc(OC)cc2C(F)(F)F)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 22248884 | 70780 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 397 | 8 | 1 | 5 | 5.3 | CCc1nc(NC(CC)CC)c(OC)nc1-c1ccc(C(F)(F)F)cc1OC | 10.1021/jm200365y | |||
| CHEMBL1807050 | 70780 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 397 | 8 | 1 | 5 | 5.3 | CCc1nc(NC(CC)CC)c(OC)nc1-c1ccc(C(F)(F)F)cc1OC | 10.1021/jm200365y | |||
| CHEMBL2372650 | 217058 | 0 | None | 2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(N)=O | 10.1021/jm990590f | |||||
| 10375 | 9516 | 18 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 416 | 6 | 0 | 4 | 6.5 | CCCC(N1CCn2c3c1cc(C)nc3c(n2)c1ccc(cc1Cl)Cl)CCC | 10.1021/jm050384+ | |||
| 9888194 | 9516 | 18 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 416 | 6 | 0 | 4 | 6.5 | CCCC(N1CCn2c3c1cc(C)nc3c(n2)c1ccc(cc1Cl)Cl)CCC | 10.1021/jm050384+ | |||
| CHEMBL188907 | 9516 | 18 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 416 | 6 | 0 | 4 | 6.5 | CCCC(N1CCn2c3c1cc(C)nc3c(n2)c1ccc(cc1Cl)Cl)CCC | 10.1021/jm050384+ | |||
| 10552437 | 65884 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 472 | 10 | 1 | 6 | 6.6 | CCCCC(CCCC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169781 | 65884 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 472 | 10 | 1 | 6 | 6.6 | CCCCC(CCCC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44341875 | 174864 | 1 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 400 | 6 | 0 | 2 | 7.5 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)ccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL432607 | 174864 | 1 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 400 | 6 | 0 | 2 | 7.5 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)ccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 21916240 | 13843 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 7 | 0 | 4 | 6.1 | C=CCN(CCC)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1084999 | 13843 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 7 | 0 | 4 | 6.1 | C=CCN(CCC)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 9912040 | 127547 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 8 | 0 | 7 | 4.3 | COCCN(CC1CC1)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL355329 | 127547 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 8 | 0 | 7 | 4.3 | COCCN(CC1CC1)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 15490820 | 175505 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 477 | 5 | 0 | 4 | 6.6 | CCN(c1nc(C)cc(-c2ccccc2C(F)(F)F)n1)c1ccc(C(C)=O)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL436978 | 175505 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 477 | 5 | 0 | 4 | 6.6 | CCN(c1nc(C)cc(-c2ccccc2C(F)(F)F)n1)c1ccc(C(C)=O)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 23595014 | 70785 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 385 | 8 | 1 | 5 | 5.3 | CCC(CC)Nc1nc(C)c(-c2ccc(OC(F)F)cc2Cl)nc1OC | 10.1021/jm200365y | |||
| CHEMBL1807055 | 70785 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 385 | 8 | 1 | 5 | 5.3 | CCC(CC)Nc1nc(C)c(-c2ccc(OC(F)F)cc2Cl)nc1OC | 10.1021/jm200365y | |||
| 10695347 | 65844 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 461 | 9 | 0 | 7 | 4.1 | COCCN(CCOC)c1cc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169561 | 65844 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 461 | 9 | 0 | 7 | 4.1 | COCCN(CCOC)c1cc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 10741252 | 127032 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 429 | 10 | 0 | 8 | 4.1 | COCCN(CCOC)c1cc(C)nc2c1nnn2-c1ccc(C(C)C)cc1SC | 10.1021/jm980224g | |||
| CHEMBL352353 | 127032 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 429 | 10 | 0 | 8 | 4.1 | COCCN(CCOC)c1cc(C)nc2c1nnn2-c1ccc(C(C)C)cc1SC | 10.1021/jm980224g | |||
| 44341901 | 16843 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 414 | 9 | 0 | 5 | 6.0 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(OC)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL115349 | 16843 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 414 | 9 | 0 | 5 | 6.0 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(OC)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 10303689 | 130606 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 579 | 8 | 1 | 4 | 9.0 | Fc1ccc(CN(CCC(F)(F)F)Cc2sc(Nc3c(Cl)cc(Cl)cc3Cl)nc2C(F)(F)F)cc1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL362448 | 130606 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 579 | 8 | 1 | 4 | 9.0 | Fc1ccc(CN(CCC(F)(F)F)Cc2sc(Nc3c(Cl)cc(Cl)cc3Cl)nc2C(F)(F)F)cc1 | 10.1016/j.bmcl.2004.10.055 | |||
| 11429341 | 74136 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 394 | 8 | 1 | 6 | 5.2 | CCCC(CCC)Nc1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL188609 | 74136 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 394 | 8 | 1 | 6 | 5.2 | CCCC(CCC)Nc1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 44392678 | 71420 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 366 | 7 | 1 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(NC)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL181812 | 71420 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 366 | 7 | 1 | 6 | 4.4 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(NC)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 44392749 | 73482 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 352 | 6 | 1 | 6 | 3.9 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(C)cc3N)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL185570 | 73482 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 352 | 6 | 1 | 6 | 3.9 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(C)cc3N)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 11153953 | 16916 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 404 | 8 | 1 | 3 | 6.6 | CCCCN(CCCC)c1cc(C)[nH]c2c(-c3ccc(Cl)cc3Cl)nnc1-2 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL115759 | 16916 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 404 | 8 | 1 | 3 | 6.6 | CCCCN(CCCC)c1cc(C)[nH]c2c(-c3ccc(Cl)cc3Cl)nnc1-2 | 10.1016/s0960-894x(03)00621-8 | |||
| 44305256 | 109134 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 376 | 6 | 0 | 4 | 5.6 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cnn12 | 10.1016/s0960-894x(98)00372-2 | |||
| CHEMBL303789 | 109134 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 376 | 6 | 0 | 4 | 5.6 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cnn12 | 10.1016/s0960-894x(98)00372-2 | |||
| 11749772 | 75422 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 394 | 5 | 0 | 5 | 4.6 | CCC(COC)N1CCc2cn(-c3ccc(Cl)cc3C#N)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL191903 | 75422 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 394 | 5 | 0 | 5 | 4.6 | CCC(COC)N1CCc2cn(-c3ccc(Cl)cc3C#N)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 44318123 | 212472 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 403 | 11 | 0 | 7 | 3.5 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2OC)n(CCOC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL82275 | 212472 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 403 | 11 | 0 | 7 | 3.5 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2OC)n(CCOC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 22248970 | 70763 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 368 | 6 | 0 | 3 | 6.5 | CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1SC(C)CC | 10.1021/jm200365y | |||
| CHEMBL1807029 | 70763 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 368 | 6 | 0 | 3 | 6.5 | CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1SC(C)CC | 10.1021/jm200365y | |||
| 44443567 | 161766 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 300 | 6 | 1 | 5 | 4.2 | CCC(CC)Nc1nc(C)c(Oc2cc(C)ccn2)nc1C | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL401295 | 161766 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 300 | 6 | 1 | 5 | 4.2 | CCC(CC)Nc1nc(C)c(Oc2cc(C)ccn2)nc1C | 10.1016/j.bmcl.2007.09.008 | |||
| 20780131 | 74319 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 504 | 7 | 0 | 4 | 7.6 | CCCN(Cc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL189714 | 74319 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 504 | 7 | 0 | 4 | 7.6 | CCCN(Cc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 10645784 | 64255 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 419 | 8 | 1 | 5 | 5.8 | CCC(CC)Nc1nc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL165824 | 64255 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 419 | 8 | 1 | 5 | 5.8 | CCC(CC)Nc1nc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 10553475 | 176274 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 500 | 10 | 0 | 8 | 5.2 | CCCCN(Cc1nnnn1C)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL443235 | 176274 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 500 | 10 | 0 | 8 | 5.2 | CCCCN(Cc1nnnn1C)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 20780279 | 129099 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 434 | 6 | 0 | 4 | 4.9 | CCc1nc2n(c1C(=O)N(CC1CC1)CC(F)(F)F)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL359832 | 129099 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 434 | 6 | 0 | 4 | 4.9 | CCc1nc2n(c1C(=O)N(CC1CC1)CC(F)(F)F)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 20780026 | 129125 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 454 | 6 | 0 | 4 | 5.3 | CCc1nc2n(c1C(=O)N(CC1CC1)CC(F)(F)F)CCN2c1c(C)cc(C)cc1Cl | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL359936 | 129125 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 454 | 6 | 0 | 4 | 5.3 | CCc1nc2n(c1C(=O)N(CC1CC1)CC(F)(F)F)CCN2c1c(C)cc(C)cc1Cl | 10.1016/j.bmcl.2005.05.117 | |||
| 44305246 | 109100 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 374 | 2 | 0 | 4 | 5.3 | Cc1cc(N2CCCCC2)n2nc(C)c(-c3ccc(Cl)cc3Cl)c2n1 | 10.1016/s0960-894x(98)00372-2 | |||
| CHEMBL303593 | 109100 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 374 | 2 | 0 | 4 | 5.3 | Cc1cc(N2CCCCC2)n2nc(C)c(-c3ccc(Cl)cc3Cl)c2n1 | 10.1016/s0960-894x(98)00372-2 | |||
| 20780161 | 100497 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 401 | 7 | 0 | 5 | 5.3 | C=CCN(CCC)Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL247152 | 100497 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 401 | 7 | 0 | 5 | 5.3 | C=CCN(CCC)Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 44446741 | 101425 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 489 | 10 | 1 | 5 | 6.3 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OCCN2CCC(O)CC2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL252494 | 101425 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 489 | 10 | 1 | 5 | 6.3 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OCCN2CCC(O)CC2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 20780154 | 74328 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 596 | 9 | 0 | 4 | 8.6 | CCCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3ccc(C(C)C)cc3Br)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL189798 | 74328 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 596 | 9 | 0 | 4 | 8.6 | CCCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3ccc(C(C)C)cc3Br)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 20780272 | 70613 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 430 | 7 | 0 | 4 | 5.6 | CCCN(Cc1ccccc1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL180284 | 70613 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 430 | 7 | 0 | 4 | 5.6 | CCCN(Cc1ccccc1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 20780061 | 100104 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 455 | 9 | 0 | 7 | 4.3 | COCCN(CCOC)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL245298 | 100104 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 455 | 9 | 0 | 7 | 4.3 | COCCN(CCOC)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 11257259 | 75099 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 371 | 10 | 0 | 4 | 5.5 | CCCC(CCC)N1CCc2cn(CCCOC(C)C)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL191650 | 75099 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 371 | 10 | 0 | 4 | 5.5 | CCCC(CCC)N1CCc2cn(CCCOC(C)C)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 10946918 | 210457 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 312 | 4 | 2 | 4 | 3.6 | CC(=O)/C(=N\Nc1ccccc1C#N)Nc1cccc(Cl)c1 | 10.1021/jm025512y | |||
| CHEMBL67448 | 210457 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 312 | 4 | 2 | 4 | 3.6 | CC(=O)/C(=N\Nc1ccccc1C#N)Nc1cccc(Cl)c1 | 10.1021/jm025512y | |||
| 10500311 | 66545 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 385 | 8 | 0 | 9 | 1.9 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1c(C)cc(C)nc1C | 10.1021/jm980224g | |||
| CHEMBL172570 | 66545 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 385 | 8 | 0 | 9 | 1.9 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1c(C)cc(C)nc1C | 10.1021/jm980224g | |||
| 11045497 | 109168 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 321 | 4 | 2 | 3 | 4.4 | CC(=O)/C(=N\Nc1ccccc1Cl)Nc1cccc(Cl)c1 | 10.1021/jm025512y | |||
| CHEMBL303931 | 109168 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 321 | 4 | 2 | 3 | 4.4 | CC(=O)/C(=N\Nc1ccccc1Cl)Nc1cccc(Cl)c1 | 10.1021/jm025512y | |||
| 11502109 | 129127 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 394 | 7 | 0 | 4 | 4.8 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL359956 | 129127 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 394 | 7 | 0 | 4 | 4.8 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 44446723 | 101581 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 378 | 8 | 0 | 4 | 5.9 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL253492 | 101581 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 378 | 8 | 0 | 4 | 5.9 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 44389111 | 179216 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 525 | 8 | 1 | 4 | 8.4 | CCCN(Cc1ccccc1F)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL447836 | 179216 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 525 | 8 | 1 | 4 | 8.4 | CCCN(Cc1ccccc1F)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 44385503 | 68108 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 461 | 7 | 1 | 7 | 4.2 | CCC(COC)Nc1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL176721 | 68108 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 461 | 7 | 1 | 7 | 4.2 | CCC(COC)Nc1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 44341949 | 117567 | 1 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 318 | 6 | 0 | 2 | 5.8 | CCCN(CCC)c1cc(C)nc2c(-c3ccccc3)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL326074 | 117567 | 1 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 318 | 6 | 0 | 2 | 5.8 | CCCN(CCC)c1cc(C)nc2c(-c3ccccc3)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 10206448 | 71344 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 485 | 9 | 1 | 4 | 7.9 | CCCN(CCC1CC1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181566 | 71344 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 485 | 9 | 1 | 4 | 7.9 | CCCN(CCC1CC1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 20780033 | 71609 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 448 | 7 | 0 | 4 | 5.7 | CCCN(Cc1cccc(F)c1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL181989 | 71609 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 448 | 7 | 0 | 4 | 5.7 | CCCN(Cc1cccc(F)c1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 20780075 | 74014 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 558 | 7 | 0 | 4 | 8.2 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCC(F)(F)F)Cc4ccccc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL187975 | 74014 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 558 | 7 | 0 | 4 | 8.2 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCC(F)(F)F)Cc4ccccc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| 11155555 | 85118 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 466 | 8 | 0 | 5 | 6.5 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)[C@H](CC)c1ccc(C(F)(F)F)cc1 | 10.1021/jm049339c | |||
| CHEMBL2093959 | 85118 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 466 | 8 | 0 | 5 | 6.5 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)[C@H](CC)c1ccc(C(F)(F)F)cc1 | 10.1021/jm049339c | |||
| CHEMBL2110007 | 85118 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 466 | 8 | 0 | 5 | 6.5 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)[C@H](CC)c1ccc(C(F)(F)F)cc1 | 10.1021/jm049339c | |||
| 10402860 | 109902 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 305 | 4 | 2 | 3 | 3.7 | CC(=O)/C(=N\c1cccc(F)c1)NNc1ccccc1Cl | 10.1021/jm025512y | |||
| CHEMBL307795 | 109902 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 305 | 4 | 2 | 3 | 3.7 | CC(=O)/C(=N\c1cccc(F)c1)NNc1ccccc1Cl | 10.1021/jm025512y | |||
| 11778680 | 210485 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 285 | 4 | 2 | 3 | 3.4 | CC(=O)/C(=N\c1cccc(F)c1)NNc1ccccc1C | 10.1021/jm025512y | |||
| CHEMBL67603 | 210485 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 285 | 4 | 2 | 3 | 3.4 | CC(=O)/C(=N\c1cccc(F)c1)NNc1ccccc1C | 10.1021/jm025512y | |||
| 44347421 | 23202 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 414 | 10 | 0 | 8 | 3.1 | COCCN(CCOC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL123197 | 23202 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 414 | 10 | 0 | 8 | 3.1 | COCCN(CCOC)c1cc(C)nc2c(-c3ccc(OC)cc3OC)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 9828535 | 172340 | 0 | None | -1 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 437 | 6 | 0 | 8 | 3.0 | CCN(c1nc(C)nc(N2CCOCC2)n1)c1c(Br)cc(OC)cc1OC | 10.1021/jm980223o | |||
| CHEMBL424204 | 172340 | 0 | None | -1 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 437 | 6 | 0 | 8 | 3.0 | CCN(c1nc(C)nc(N2CCOCC2)n1)c1c(Br)cc(OC)cc1OC | 10.1021/jm980223o | |||
| CHEMBL43216 | 172340 | 0 | None | -1 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 437 | 6 | 0 | 8 | 3.0 | CCN(c1nc(C)nc(N2CCOCC2)n1)c1c(Br)cc(OC)cc1OC | 10.1021/jm980223o | |||
| 21916338 | 13343 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 542 | 7 | 0 | 4 | 7.7 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCC(F)(F)F)Cc4ccccc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083035 | 13343 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 542 | 7 | 0 | 4 | 7.7 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCC(F)(F)F)Cc4ccccc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 20780150 | 151878 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 429 | 8 | 0 | 5 | 5.9 | CCCN(CCC1CC1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL391170 | 151878 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 429 | 8 | 0 | 5 | 5.9 | CCCN(CCC1CC1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 10164617 | 71246 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 511 | 7 | 1 | 4 | 7.6 | FC(F)(F)CN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181381 | 71246 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 511 | 7 | 1 | 4 | 7.6 | FC(F)(F)CN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| 46890888 | 13298 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 475 | 6 | 0 | 5 | 5.8 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(C)CCc4ccccn4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1082807 | 13298 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 475 | 6 | 0 | 5 | 5.8 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(C)CCc4ccccn4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 10477079 | 101216 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 417 | 8 | 1 | 5 | 5.8 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2cccc(C)c2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL251199 | 101216 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 417 | 8 | 1 | 5 | 5.8 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2cccc(C)c2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| 44317800 | 211993 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 362 | 7 | 1 | 3 | 5.2 | Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2C)c(F)c1 | 10.1021/jm049974i | |||
| CHEMBL78608 | 211993 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 362 | 7 | 1 | 3 | 5.2 | Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2C)c(F)c1 | 10.1021/jm049974i | |||
| 9865434 | 74804 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 394 | 7 | 0 | 6 | 4.3 | CCCC(CCC)N1CCn2c(=O)n(-c3ccccc3OC)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL191395 | 74804 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 394 | 7 | 0 | 6 | 4.3 | CCCC(CCC)N1CCn2c(=O)n(-c3ccccc3OC)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 10526779 | 64903 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 432 | 9 | 1 | 4 | 6.7 | CCC(CC)CNc1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL167738 | 64903 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 432 | 9 | 1 | 4 | 6.7 | CCC(CC)CNc1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 10763375 | 122122 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 397 | 3 | 0 | 5 | 5.5 | Cc1nc(N(C)c2ccccc2)n2nc(C)c(-c3ccc(Cl)cc3Cl)c2n1 | 10.1021/jm9904351 | |||
| CHEMBL334935 | 122122 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 397 | 3 | 0 | 5 | 5.5 | Cc1nc(N(C)c2ccccc2)n2nc(C)c(-c3ccc(Cl)cc3Cl)c2n1 | 10.1021/jm9904351 | |||
| CHEMBL2372938 | 217098 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)C(CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm034180+ | |||||
| 21916309 | 14045 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 530 | 7 | 0 | 4 | 7.1 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12)CC(F)(F)C(F)(F)F | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1085989 | 14045 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 530 | 7 | 0 | 4 | 7.1 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12)CC(F)(F)C(F)(F)F | 10.1016/j.bmcl.2010.04.094 | |||
| 11486120 | 69768 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 390 | 10 | 0 | 5 | 5.3 | CCCCC(CC)N(CC1CC1)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL178618 | 69768 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 390 | 10 | 0 | 5 | 5.3 | CCCCC(CC)N(CC1CC1)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 21916155 | 14278 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 424 | 3 | 0 | 5 | 4.9 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN2CCSCC2)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1087174 | 14278 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 424 | 3 | 0 | 5 | 4.9 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN2CCSCC2)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| 10739049 | 64545 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 387 | 2 | 0 | 3 | 5.7 | Cc1cc(Cl)nc2c1c(C#N)cn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980223o | |||
| CHEMBL166946 | 64545 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 387 | 2 | 0 | 3 | 5.7 | Cc1cc(Cl)nc2c1c(C#N)cn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980223o | |||
| 54586411 | 68426 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 387 | 5 | 1 | 5 | 4.6 | CCN(CCN)c1nc(C)nc2c1c1ccccc1n2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.12.116 | |||
| CHEMBL1771267 | 68426 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 387 | 5 | 1 | 5 | 4.6 | CCN(CCN)c1nc(C)nc2c1c1ccccc1n2-c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.12.116 | |||
| CHEMBL2372900 | 217084 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm034180+ | |||||
| 9870876 | 71385 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 506 | 7 | 0 | 6 | 7.8 | CCC(C)N(c1nc(C)nc2c1sc(=S)n2-c1ccc(C(C)C)cc1Br)C(C)CC | 10.1016/s0960-894x(99)00159-6 | |||
| CHEMBL18173 | 71385 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 506 | 7 | 0 | 6 | 7.8 | CCC(C)N(c1nc(C)nc2c1sc(=S)n2-c1ccc(C(C)C)cc1Br)C(C)CC | 10.1016/s0960-894x(99)00159-6 | |||
| 10316753 | 67265 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 364 | 7 | 1 | 3 | 5.2 | CCCN(c1n[nH]c(-c2ccc(Cl)cc2Cl)n1)C(C1CC1)C1CC1 | 10.1021/jm049339c | |||
| CHEMBL175536 | 67265 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 364 | 7 | 1 | 3 | 5.2 | CCCN(c1n[nH]c(-c2ccc(Cl)cc2Cl)n1)C(C1CC1)C1CC1 | 10.1021/jm049339c | |||
| 10025032 | 162017 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 5.2 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2ccc(C)cn2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL402717 | 162017 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 5.2 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2ccc(C)cn2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| 20780068 | 130864 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 536 | 8 | 0 | 4 | 7.8 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCC4CC4)CCC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL363281 | 130864 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 536 | 8 | 0 | 4 | 7.8 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCC4CC4)CCC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| 10549751 | 127213 | 1 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 414 | 3 | 0 | 6 | 4.4 | Cc1nc(N2CCCCC2)c2nnn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980224g | |||
| CHEMBL353856 | 127213 | 1 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 414 | 3 | 0 | 6 | 4.4 | Cc1nc(N2CCCCC2)c2nnn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980224g | |||
| 44341777 | 16980 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 416 | 7 | 0 | 4 | 6.4 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(CC)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL115999 | 16980 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 416 | 7 | 0 | 4 | 6.4 | CCCN(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(CC)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 10831554 | 64809 | 1 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 347 | 4 | 0 | 3 | 5.1 | CCN(c1nc(C)cc(C)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980223o | |||
| CHEMBL167264 | 64809 | 1 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 347 | 4 | 0 | 3 | 5.1 | CCN(c1nc(C)cc(C)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980223o | |||
| 10831554 | 64809 | 1 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 347 | 4 | 0 | 3 | 5.1 | CCN(c1nc(C)cc(C)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980222w | |||
| CHEMBL167264 | 64809 | 1 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 347 | 4 | 0 | 3 | 5.1 | CCN(c1nc(C)cc(C)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm980222w | |||
| 10155816 | 70762 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 366 | 7 | 0 | 3 | 6.1 | CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1OC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1807028 | 70762 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 366 | 7 | 0 | 3 | 6.1 | CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1OC(CC)CC | 10.1021/jm200365y | |||
| 18672272 | 69267 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 525 | 8 | 1 | 4 | 8.0 | FC(F)(F)CCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL178081 | 69267 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 525 | 8 | 1 | 4 | 8.0 | FC(F)(F)CCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| 11247792 | 85119 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 444 | 10 | 0 | 5 | 6.4 | CCCC[C@H](c1ccc(F)cc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL2093960 | 85119 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 444 | 10 | 0 | 5 | 6.4 | CCCC[C@H](c1ccc(F)cc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL2110008 | 85119 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 444 | 10 | 0 | 5 | 6.4 | CCCC[C@H](c1ccc(F)cc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 11383383 | 130719 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 378 | 10 | 0 | 5 | 5.3 | CCCCC(CC)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL362847 | 130719 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 378 | 10 | 0 | 5 | 5.3 | CCCCC(CC)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 11154954 | 74751 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 442 | 7 | 0 | 7 | 3.7 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(S(C)(=O)=O)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL191188 | 74751 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 442 | 7 | 0 | 7 | 3.7 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(S(C)(=O)=O)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 23000016 | 16338 | 1 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 301 | 1 | 0 | 1 | 5.8 | Cc1cc(C)c2cccc(-c3ccc(Cl)cc3Cl)c2n1 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL112389 | 16338 | 1 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 301 | 1 | 0 | 1 | 5.8 | Cc1cc(C)c2cccc(-c3ccc(Cl)cc3Cl)c2n1 | 10.1016/s0960-894x(03)00684-x | |||
| 44306185 | 109580 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 367 | 9 | 0 | 5 | 4.6 | CCCN(c1nccc(-c2ccc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL305354 | 109580 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 367 | 9 | 0 | 5 | 4.6 | CCCN(c1nccc(-c2ccc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| 44352436 | 123772 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 437 | 8 | 1 | 4 | 6.8 | CCCN(Cc1sc(Nc2ccc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL338780 | 123772 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 437 | 8 | 1 | 4 | 6.8 | CCCN(Cc1sc(Nc2ccc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 44387214 | 67580 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 458 | 7 | 0 | 5 | 5.5 | CCCCN(CC)c1nc(C)cc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL176176 | 67580 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 458 | 7 | 0 | 5 | 5.5 | CCCCN(CC)c1nc(C)cc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 44443605 | 100849 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 378 | 8 | 2 | 6 | 4.2 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1NC(CO)c1ccccc1 | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL249012 | 100849 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 378 | 8 | 2 | 6 | 4.2 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1NC(CO)c1ccccc1 | 10.1016/j.bmcl.2007.09.008 | |||
| 44317728 | 112385 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 432 | 7 | 1 | 3 | 6.4 | Cc1ccccc1C(Nc1ccc(Cl)cc1C(F)(F)F)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| CHEMBL312239 | 112385 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 432 | 7 | 1 | 3 | 6.4 | Cc1ccccc1C(Nc1ccc(Cl)cc1C(F)(F)F)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| 44318109 | 212783 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 385 | 8 | 0 | 5 | 5.1 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)n(C(C)C)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL84892 | 212783 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 385 | 8 | 0 | 5 | 5.1 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)n(C(C)C)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 10497535 | 65886 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 342 | 2 | 0 | 2 | 5.5 | Cc1cc(C)c2ccn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| CHEMBL169784 | 65886 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 342 | 2 | 0 | 2 | 5.5 | Cc1cc(C)c2ccn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| 44384780 | 66551 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 461 | 7 | 0 | 7 | 3.8 | CCN(CCOC)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL172606 | 66551 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 461 | 7 | 0 | 7 | 3.8 | CCN(CCOC)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 22324333 | 112397 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 359 | 8 | 0 | 6 | 3.4 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2OC)n(C)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL312336 | 112397 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 359 | 8 | 0 | 6 | 3.4 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2OC)n(C)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 44392776 | 72045 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 373 | 5 | 0 | 4 | 5.4 | CCN(c1ccccc1)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL182825 | 72045 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 373 | 5 | 0 | 4 | 5.4 | CCN(c1ccccc1)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 46891115 | 13581 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 418 | 7 | 0 | 4 | 5.7 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)ccn12)CC1CC1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083920 | 13581 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 418 | 7 | 0 | 4 | 5.7 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)ccn12)CC1CC1 | 10.1016/j.bmcl.2010.04.094 | |||
| 11032842 | 210871 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 267 | 4 | 2 | 3 | 3.2 | CC(=O)/C(=N\c1cccc(C)c1)NNc1ccccc1 | 10.1021/jm025512y | |||
| CHEMBL70195 | 210871 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 267 | 4 | 2 | 3 | 3.2 | CC(=O)/C(=N\c1cccc(C)c1)NNc1ccccc1 | 10.1021/jm025512y | |||
| 44443642 | 174315 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 5.2 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2cccc(C)n2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL430019 | 174315 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 5.2 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2cccc(C)n2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| 10623894 | 65904 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 461 | 10 | 0 | 9 | 2.8 | COCCN(CCOC)c1cc(C)nc2c1nnn2-c1ccc(C(C)C)cc1S(C)(=O)=O | 10.1021/jm980224g | |||
| CHEMBL169841 | 65904 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 461 | 10 | 0 | 9 | 2.8 | COCCN(CCOC)c1cc(C)nc2c1nnn2-c1ccc(C(C)C)cc1S(C)(=O)=O | 10.1021/jm980224g | |||
| 11796523 | 127152 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 422 | 8 | 0 | 6 | 4.6 | CCN(CC)c1cc(C)nc(N(CC)c2c(Br)cc(OC)cc2OC)n1 | 10.1021/jm980222w | |||
| CHEMBL353296 | 127152 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 422 | 8 | 0 | 6 | 4.6 | CCN(CC)c1cc(C)nc(N(CC)c2c(Br)cc(OC)cc2OC)n1 | 10.1021/jm980222w | |||
| 44380639 | 127585 | 1 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 381 | 3 | 0 | 3 | 4.6 | Cc1cc(C)nc(N(C)c2ccc(C(C)C)cc2I)n1 | 10.1021/jm980223o | |||
| CHEMBL355624 | 127585 | 1 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 381 | 3 | 0 | 3 | 4.6 | Cc1cc(C)nc(N(C)c2ccc(C(C)C)cc2I)n1 | 10.1021/jm980223o | |||
| 20780051 | 100648 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 483 | 5 | 0 | 5 | 6.5 | Cc1cc(C)c(-n2c3ncccc3n3c(CN4CCCC4Cc4ccccc4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL247958 | 100648 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 483 | 5 | 0 | 5 | 6.5 | Cc1cc(C)c(-n2c3ncccc3n3c(CN4CCCC4Cc4ccccc4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| 21916263 | 12360 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 420 | 7 | 0 | 4 | 5.8 | C=CCN(CCC)Cc1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1077156 | 12360 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 420 | 7 | 0 | 4 | 5.8 | C=CCN(CCC)Cc1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| 44381252 | 127260 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 493 | 10 | 0 | 10 | 2.5 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1c(Br)cc(OC)cc1N(C)C | 10.1021/jm980224g | |||
| CHEMBL354280 | 127260 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 493 | 10 | 0 | 10 | 2.5 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1c(Br)cc(OC)cc1N(C)C | 10.1021/jm980224g | |||
| 44381175 | 65645 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 495 | 8 | 0 | 8 | 4.5 | COCCN(Cc1cccnc1)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL168858 | 65645 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 495 | 8 | 0 | 8 | 4.5 | COCCN(Cc1cccnc1)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 127033837 | 145406 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 3901 | 126 | 54 | 50 | -8.8 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)C1CCSSCCC(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3775831 | 145406 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 3901 | 126 | 54 | 50 | -8.8 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)C1CCSSCCC(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL2372937 | 217097 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)C(CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm034180+ | |||||
| 127034112 | 145387 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 4252 | 133 | 59 | 54 | -8.7 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)C1CCSSCCC(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)NC(Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3775707 | 145387 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 4252 | 133 | 59 | 54 | -8.7 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)C1CCSSCCC(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)NC(Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)C(=O)N[C@H](Cc2ccc(NC(N)=O)cc2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| 44392775 | 131425 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 399 | 10 | 0 | 6 | 4.6 | CCCN(CC1CC1)c1cc(C(C)c2c(OC)cc(OC)cc2OC)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL364117 | 131425 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 399 | 10 | 0 | 6 | 4.6 | CCCN(CC1CC1)c1cc(C(C)c2c(OC)cc(OC)cc2OC)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| 46890768 | 13503 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 488 | 6 | 0 | 4 | 7.1 | CCN(Cc1ccccc1C)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083720 | 13503 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 488 | 6 | 0 | 4 | 7.1 | CCN(Cc1ccccc1C)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 53310276 | 70757 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 380 | 7 | 1 | 4 | 4.9 | CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1NC(C)CN(C)C | 10.1021/jm200365y | |||
| CHEMBL1807023 | 70757 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 380 | 7 | 1 | 4 | 4.9 | CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1NC(C)CN(C)C | 10.1021/jm200365y | |||
| 19063905 | 209748 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 399 | 7 | 0 | 3 | 5.6 | CCCN(c1ncc(C)c(-c2ccc(Br)cc2)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL63029 | 209748 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 399 | 7 | 0 | 3 | 5.6 | CCCN(c1ncc(C)c(-c2ccc(Br)cc2)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| 21916094 | 13344 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 560 | 7 | 0 | 4 | 7.8 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCC(F)(F)F)Cc4cccc(F)c4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083036 | 13344 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 560 | 7 | 0 | 4 | 7.8 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCC(F)(F)F)Cc4cccc(F)c4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 11387007 | 175617 | 1 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 530 | 8 | 1 | 7 | 6.3 | COC(=O)c1cccc(COc2ccc(S(=O)(=O)c3ccc(C)nc3Nc3c(C)cc(C)cc3C)cc2)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL437893 | 175617 | 1 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 530 | 8 | 1 | 7 | 6.3 | COC(=O)c1cccc(COc2ccc(S(=O)(=O)c3ccc(C)nc3Nc3c(C)cc(C)cc3C)cc2)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| 44446728 | 101611 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 362 | 7 | 0 | 3 | 6.2 | CCCN(CCC)c1cnc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL253701 | 101611 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 362 | 7 | 0 | 3 | 6.2 | CCCN(CCC)c1cnc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 11175998 | 140396 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 364 | 4 | 0 | 4 | 5.0 | CCCCN1CCc2cn(-c3ccc(Cl)cc3C#N)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL371367 | 140396 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 364 | 4 | 0 | 4 | 5.0 | CCCCN1CCc2cn(-c3ccc(Cl)cc3C#N)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 10547488 | 109853 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 375 | 7 | 1 | 5 | 5.3 | CCCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960148m | |||
| CHEMBL307419 | 109853 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 375 | 7 | 1 | 5 | 5.3 | CCCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960148m | |||
| 10808133 | 170200 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 355 | 9 | 1 | 5 | 5.3 | CCCCN(CCCC)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960148m | |||
| CHEMBL419636 | 170200 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 355 | 9 | 1 | 5 | 5.3 | CCCCN(CCCC)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960148m | |||
| 10547488 | 109853 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 375 | 7 | 1 | 5 | 5.3 | CCCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm9900117 | |||
| CHEMBL307419 | 109853 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 375 | 7 | 1 | 5 | 5.3 | CCCN(Cc1ccccc1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm9900117 | |||
| 10808133 | 170200 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 355 | 9 | 1 | 5 | 5.3 | CCCCN(CCCC)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm9900117 | |||
| CHEMBL419636 | 170200 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 355 | 9 | 1 | 5 | 5.3 | CCCCN(CCCC)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm9900117 | |||
| 9931738 | 67943 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 416 | 8 | 0 | 8 | 3.2 | COCCN(CCOC)c1nc(C)nc2c1sc(=O)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00159-6 | |||
| CHEMBL17656 | 67943 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 416 | 8 | 0 | 8 | 3.2 | COCCN(CCOC)c1nc(C)nc2c1sc(=O)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00159-6 | |||
| 10646276 | 64316 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 429 | 8 | 0 | 5 | 5.4 | C=CCN(c1nc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1)C1CC1 | 10.1021/jm980222w | |||
| CHEMBL166345 | 64316 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 429 | 8 | 0 | 5 | 5.4 | C=CCN(c1nc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1)C1CC1 | 10.1021/jm980222w | |||
| 10694122 | 64322 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 433 | 9 | 0 | 5 | 5.9 | CCCCN(CC)c1nc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL166388 | 64322 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 433 | 9 | 0 | 5 | 5.9 | CCCCN(CC)c1nc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 10809708 | 64463 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 378 | 5 | 0 | 5 | 4.1 | CCN(c1nc(C)cc(C)n1)c1c(Br)cc(N(C)C)cc1OC | 10.1021/jm980222w | |||
| CHEMBL166895 | 64463 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 378 | 5 | 0 | 5 | 4.1 | CCN(c1nc(C)cc(C)n1)c1c(Br)cc(N(C)C)cc1OC | 10.1021/jm980222w | |||
| 11795557 | 64614 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 404 | 7 | 0 | 5 | 4.8 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(C(C)=O)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL167177 | 64614 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 404 | 7 | 0 | 5 | 4.8 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(C(C)=O)cc2Br)n1 | 10.1021/jm980222w | |||
| 10503074 | 64868 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 436 | 9 | 0 | 6 | 5.0 | CCCN(CC1CC1)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C(F)(F)F)n1 | 10.1021/jm980222w | |||
| CHEMBL167428 | 64868 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 436 | 9 | 0 | 6 | 5.0 | CCCN(CC1CC1)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C(F)(F)F)n1 | 10.1021/jm980222w | |||
| 11796930 | 127218 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 430 | 8 | 0 | 4 | 6.2 | CCCN(c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1)C1CC1 | 10.1021/jm980222w | |||
| CHEMBL353877 | 127218 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 430 | 8 | 0 | 4 | 6.2 | CCCN(c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1)C1CC1 | 10.1021/jm980222w | |||
| 10646531 | 127252 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 435 | 9 | 0 | 7 | 4.6 | CCCN(CCC#N)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C(F)(F)F)n1 | 10.1021/jm980222w | |||
| CHEMBL354178 | 127252 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 435 | 9 | 0 | 7 | 4.6 | CCCN(CCC#N)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C(F)(F)F)n1 | 10.1021/jm980222w | |||
| 10838302 | 127269 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 475 | 9 | 0 | 6 | 5.6 | CCCCN(CC)c1nc(C)nc(N(CC)c2ccc(OC(F)(F)F)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL354367 | 127269 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 475 | 9 | 0 | 6 | 5.6 | CCCCN(CC)c1nc(C)nc(N(CC)c2ccc(OC(F)(F)F)cc2Br)n1 | 10.1021/jm980222w | |||
| 10527467 | 127272 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 448 | 9 | 0 | 6 | 5.0 | CCN(c1nc(C)nc(N(CC2CC2)CC2CC2)n1)c1ccc(N(C)C)cc1C(F)(F)F | 10.1021/jm980222w | |||
| CHEMBL354395 | 127272 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 448 | 9 | 0 | 6 | 5.0 | CCN(c1nc(C)nc(N(CC2CC2)CC2CC2)n1)c1ccc(N(C)C)cc1C(F)(F)F | 10.1021/jm980222w | |||
| 10366978 | 108162 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 459 | 7 | 0 | 6 | 4.9 | CCCCN(CC)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL297170 | 108162 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 459 | 7 | 0 | 6 | 4.9 | CCCCN(CC)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 9935525 | 65400 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 494 | 8 | 0 | 7 | 5.1 | COCCN(Cc1ccccc1)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL168449 | 65400 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 494 | 8 | 0 | 7 | 5.1 | COCCN(Cc1ccccc1)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 11759092 | 16808 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 321 | 1 | 0 | 1 | 6.2 | Cc1cc(Cl)c2cccc(-c3ccc(Cl)cc3Cl)c2n1 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL115119 | 16808 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 321 | 1 | 0 | 1 | 6.2 | Cc1cc(Cl)c2cccc(-c3ccc(Cl)cc3Cl)c2n1 | 10.1016/s0960-894x(03)00684-x | |||
| 9907170 | 184878 | 0 | None | 2 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 365 | 5 | 0 | 5 | 4.0 | CCN(c1nc(C)cc(C)n1)c1c(Br)cc(OC)cc1OC | 10.1021/jm980223o | |||
| CHEMBL46479 | 184878 | 0 | None | 2 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 365 | 5 | 0 | 5 | 4.0 | CCN(c1nc(C)cc(C)n1)c1c(Br)cc(OC)cc1OC | 10.1021/jm980223o | |||
| 10366978 | 108162 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 459 | 7 | 0 | 6 | 4.9 | CCCCN(CC)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm990590f | |||
| CHEMBL297170 | 108162 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 459 | 7 | 0 | 6 | 4.9 | CCCCN(CC)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm990590f | |||
| 9800614 | 107243 | 5 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm990590f | |||
| CHEMBL290762 | 107243 | 5 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm990590f | |||
| 3520 | 10041 | 54 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/s0960-894x(02)00358-x | |||
| 9821250 | 10041 | 54 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL309138 | 10041 | 54 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1016/s0960-894x(02)00358-x | |||
| 9800614 | 107243 | 5 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| CHEMBL290762 | 107243 | 5 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 390 | 6 | 0 | 4 | 5.9 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| 137659453 | 165900 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 7.0 | CCCCc1nn2c(N(CC)CCCC)cc(C)nc2c1-c1ccc(Cl)cc1Cl | 10.1016/j.ejmech.2016.11.019 | |||
| CHEMBL4097805 | 165900 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 7.0 | CCCCc1nn2c(N(CC)CCCC)cc(C)nc2c1-c1ccc(Cl)cc1Cl | 10.1016/j.ejmech.2016.11.019 | |||
| 44446730 | 162339 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 388 | 7 | 0 | 3 | 6.5 | CCCN(CC1CC1)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL404351 | 162339 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 388 | 7 | 0 | 3 | 6.5 | CCCN(CC1CC1)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 10375 | 9516 | 18 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 416 | 6 | 0 | 4 | 6.5 | CCCC(N1CCn2c3c1cc(C)nc3c(n2)c1ccc(cc1Cl)Cl)CCC | 10.1021/jm049085v | |||
| 9888194 | 9516 | 18 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 416 | 6 | 0 | 4 | 6.5 | CCCC(N1CCn2c3c1cc(C)nc3c(n2)c1ccc(cc1Cl)Cl)CCC | 10.1021/jm049085v | |||
| CHEMBL188907 | 9516 | 18 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 416 | 6 | 0 | 4 | 6.5 | CCCC(N1CCn2c3c1cc(C)nc3c(n2)c1ccc(cc1Cl)Cl)CCC | 10.1021/jm049085v | |||
| 9933199 | 78281 | 1 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 444 | 8 | 0 | 4 | 7.3 | CCCCC(CCCC)N1CCn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc1c32 | 10.1021/jm049085v | |||
| CHEMBL196270 | 78281 | 1 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 444 | 8 | 0 | 4 | 7.3 | CCCCC(CCCC)N1CCn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc1c32 | 10.1021/jm049085v | |||
| 11718607 | 142000 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 414 | 4 | 0 | 4 | 6.0 | Cc1cc2c3c(n1)c(-c1ccc(Cl)cc1Cl)nn3C[C@H](C(C)C)N2CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL372319 | 142000 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 414 | 4 | 0 | 4 | 6.0 | Cc1cc2c3c(n1)c(-c1ccc(Cl)cc1Cl)nn3C[C@H](C(C)C)N2CC1CC1 | 10.1021/jm049085v | |||
| 9824168 | 74407 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 432 | 6 | 0 | 5 | 5.6 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(Cl)cc3Cl)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL190488 | 74407 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 432 | 6 | 0 | 5 | 5.6 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(Cl)cc3Cl)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 10837003 | 66572 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 443 | 8 | 1 | 5 | 6.4 | CCCCC(CC)Nc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL172684 | 66572 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 443 | 8 | 1 | 5 | 6.4 | CCCCC(CC)Nc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44341862 | 16310 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 392 | 8 | 0 | 4 | 6.3 | CCCCN(CCCC)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL112264 | 16310 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 392 | 8 | 0 | 4 | 6.3 | CCCCN(CCCC)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 12086065 | 17607 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 406 | 7 | 0 | 5 | 5.1 | CCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL117209 | 17607 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 406 | 7 | 0 | 5 | 5.1 | CCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 10693263 | 65853 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 416 | 6 | 1 | 6 | 5.0 | CCC(CC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169577 | 65853 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 416 | 6 | 1 | 6 | 5.0 | CCC(CC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 10549179 | 127594 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 403 | 8 | 0 | 7 | 4.4 | CCCCN(CC)c1nc(C)nc2c1ncn2-c1c(Cl)cc(OC)cc1OC | 10.1021/jm980224g | |||
| CHEMBL355721 | 127594 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 403 | 8 | 0 | 7 | 4.4 | CCCCN(CC)c1nc(C)nc2c1ncn2-c1c(Cl)cc(OC)cc1OC | 10.1021/jm980224g | |||
| 20780267 | 13590 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 492 | 6 | 0 | 4 | 6.5 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CC4CC4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083933 | 13590 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 492 | 6 | 0 | 4 | 6.5 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CC4CC4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 11386550 | 85105 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 466 | 8 | 0 | 5 | 6.5 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)[C@@H](CC)c1ccc(C(F)(F)F)cc1 | 10.1021/jm049339c | |||
| CHEMBL2094043 | 85105 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 466 | 8 | 0 | 5 | 6.5 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)[C@@H](CC)c1ccc(C(F)(F)F)cc1 | 10.1021/jm049339c | |||
| CHEMBL2109791 | 85105 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 466 | 8 | 0 | 5 | 6.5 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)[C@@H](CC)c1ccc(C(F)(F)F)cc1 | 10.1021/jm049339c | |||
| 11383860 | 73797 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 394 | 7 | 0 | 6 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL187039 | 73797 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 394 | 7 | 0 | 6 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3c(C)cc(N(C)C)nc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 11201203 | 134057 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 428 | 7 | 0 | 6 | 5.2 | CCCN(Cc1ccccc1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL365841 | 134057 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 428 | 7 | 0 | 6 | 5.2 | CCCN(Cc1ccccc1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 20780254 | 13598 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 466 | 7 | 0 | 4 | 6.7 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12)CC1CCC1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083952 | 13598 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 466 | 7 | 0 | 4 | 6.7 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12)CC1CCC1 | 10.1016/j.bmcl.2010.04.094 | |||
| 122193719 | 130738 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 386 | 6 | 1 | 4 | 5.1 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1C | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628738 | 130738 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 386 | 6 | 1 | 4 | 5.1 | CCCCN(CC)c1cc(C)nc2c1NC(=O)CN2c1ccc(Cl)cc1C | 10.1016/j.bmcl.2015.10.010 | |||
| 11362799 | 78047 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 408 | 8 | 0 | 6 | 5.1 | CCCC(CCC)N1CCc2cn(-c3ccc(OC)nc3OC)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL195699 | 78047 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 408 | 8 | 0 | 6 | 5.1 | CCCC(CCC)N1CCc2cn(-c3ccc(OC)nc3OC)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL386892 | 219178 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N1)[C@@H](C)CC)C(N)=O | 10.1021/jm034180+ | |||||
| 10178818 | 70720 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 395 | 8 | 1 | 4 | 5.9 | CCc1nc(-c2ccc(C(F)(F)F)cc2OC)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1806734 | 70720 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 395 | 8 | 1 | 4 | 5.9 | CCc1nc(-c2ccc(C(F)(F)F)cc2OC)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 11372928 | 177049 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 398 | 7 | 0 | 6 | 4.5 | CCCN(CCC)c1c(F)c(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL444614 | 177049 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 398 | 7 | 0 | 6 | 4.5 | CCCN(CCC)c1c(F)c(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 10205521 | 175283 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 471 | 7 | 0 | 6 | 4.9 | CCCN(CC1CC1)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL435345 | 175283 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 471 | 7 | 0 | 6 | 4.9 | CCCN(CC1CC1)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 10593122 | 65537 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 338 | 5 | 1 | 6 | 4.0 | CCC(CC)Nc1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL168664 | 65537 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 338 | 5 | 1 | 6 | 4.0 | CCC(CC)Nc1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| 44341636 | 16467 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL113097 | 16467 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 386 | 6 | 0 | 2 | 7.1 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 44341743 | 117360 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 418 | 8 | 0 | 4 | 5.6 | COCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL325430 | 117360 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 418 | 8 | 0 | 4 | 5.6 | COCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 11165678 | 85121 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 406 | 10 | 0 | 5 | 5.9 | CCCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL2093962 | 85121 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 406 | 10 | 0 | 5 | 5.9 | CCCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL2110010 | 85121 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 406 | 10 | 0 | 5 | 5.9 | CCCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| 18691320 | 11511 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 513 | 4 | 0 | 3 | 7.2 | CCN(c1nc(C)cc(-c2ccccc2C(F)(F)F)n1)c1ccc(Br)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL10373 | 11511 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 513 | 4 | 0 | 3 | 7.2 | CCN(c1nc(C)cc(-c2ccccc2C(F)(F)F)n1)c1ccc(Br)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 18691324 | 103781 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 434 | 5 | 0 | 4 | 6.4 | CCN(c1nc(C)cc(-c2ccccc2C#N)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL266617 | 103781 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 434 | 5 | 0 | 4 | 6.4 | CCN(c1nc(C)cc(-c2ccccc2C#N)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 10813902 | 64907 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 461 | 9 | 0 | 7 | 4.1 | COCCN(CCOC)c1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL167777 | 64907 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 461 | 9 | 0 | 7 | 4.1 | COCCN(CCOC)c1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 22249149 | 70769 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 367 | 7 | 1 | 4 | 5.6 | CCc1nc(NC(CC)CC)c(OC)nc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| CHEMBL1807035 | 70769 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 367 | 7 | 1 | 4 | 5.6 | CCc1nc(NC(CC)CC)c(OC)nc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| 9969024 | 70786 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 363 | 8 | 1 | 5 | 5.1 | CCOc1ccc(-c2nc(OC)c(NC(CC)CC)nc2C)c(Cl)c1 | 10.1021/jm200365y | |||
| CHEMBL1807056 | 70786 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 363 | 8 | 1 | 5 | 5.1 | CCOc1ccc(-c2nc(OC)c(NC(CC)CC)nc2C)c(Cl)c1 | 10.1021/jm200365y | |||
| 21916308 | 100573 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 485 | 8 | 0 | 5 | 6.7 | CCCN(CCc1ccccc1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL247557 | 100573 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 485 | 8 | 0 | 5 | 6.7 | CCCN(CCc1ccccc1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL4299287 | 220339 | 0 | None | -2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | None | None | None | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)(CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC(=O)C(CCCC)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(=O)O)NC(C)=O)[C@H](C)O)C(C)C)C(=O)N[C@H](Cc2ccc(NC(=O)[C@@H]3CC(=O)NC(=O)N3)cc2)C(=O)N[C@@H](Cc2ccc(NC(N)=O)cc2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)NC(C)(CC(C)C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||||
| CHEMBL2372922 | 217092 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC | 10.1021/jm034180+ | |||||
| 20780182 | 100614 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 435 | 7 | 0 | 5 | 5.9 | CCN(CCC1CC1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL247753 | 100614 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 435 | 7 | 0 | 5 | 5.9 | CCN(CCC1CC1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 10166565 | 71097 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 561 | 8 | 1 | 4 | 8.5 | FC(F)(F)CN(CCc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181133 | 71097 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 561 | 8 | 1 | 4 | 8.5 | FC(F)(F)CN(CCc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 11598824 | 78559 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 404 | 5 | 0 | 5 | 5.0 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1CCOC | 10.1021/jm049085v | |||
| CHEMBL196740 | 78559 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 404 | 5 | 0 | 5 | 5.0 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1CCOC | 10.1021/jm049085v | |||
| 11660986 | 147040 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 384 | 4 | 0 | 4 | 5.2 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3F)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL380563 | 147040 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 384 | 4 | 0 | 4 | 5.2 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3F)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 10157369 | 122035 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 391 | 5 | 1 | 4 | 5.6 | CCN(CC)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL334778 | 122035 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 391 | 5 | 1 | 4 | 5.6 | CCN(CC)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C | 10.1016/j.bmcl.2003.08.055 | |||
| 11610200 | 78506 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 360 | 2 | 0 | 4 | 4.9 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1C | 10.1021/jm049085v | |||
| CHEMBL196594 | 78506 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 360 | 2 | 0 | 4 | 4.9 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1C | 10.1021/jm049085v | |||
| 9928790 | 200334 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 359 | 9 | 0 | 6 | 4.1 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL526828 | 200334 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 359 | 9 | 0 | 6 | 4.1 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| 11742775 | 161554 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 5.2 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2ncccc2C)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL400156 | 161554 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 5.2 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2ncccc2C)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| 11067569 | 210402 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 332 | 5 | 2 | 5 | 3.5 | CC(=O)/C(=N\c1cccc(Cl)c1)NNc1ccccc1[N+](=O)[O-] | 10.1021/jm025512y | |||
| CHEMBL67121 | 210402 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 332 | 5 | 2 | 5 | 3.5 | CC(=O)/C(=N\c1cccc(Cl)c1)NNc1ccccc1[N+](=O)[O-] | 10.1021/jm025512y | |||
| 10786789 | 65274 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 393 | 5 | 0 | 4 | 5.9 | CCN(c1nc(C)cc(C)n1)c1c(Br)cc(C(C)C)cc1SC | 10.1021/jm980222w | |||
| CHEMBL168341 | 65274 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 393 | 5 | 0 | 4 | 5.9 | CCN(c1nc(C)cc(C)n1)c1c(Br)cc(C(C)C)cc1SC | 10.1021/jm980222w | |||
| 44443654 | 100842 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 9 | 1 | 7 | 4.6 | CCc1nc(Oc2cc(C)ncn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OCCF | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL248996 | 100842 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 437 | 9 | 1 | 7 | 4.6 | CCc1nc(Oc2cc(C)ncn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OCCF | 10.1016/j.bmcl.2007.09.008 | |||
| 11474841 | 85120 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 392 | 9 | 0 | 5 | 5.6 | CCC[C@H](c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL2093961 | 85120 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 392 | 9 | 0 | 5 | 5.6 | CCC[C@H](c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL2110009 | 85120 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 392 | 9 | 0 | 5 | 5.6 | CCC[C@H](c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| 44352358 | 25518 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 429 | 10 | 1 | 6 | 5.5 | CCCN(Cc1sc(Nc2ccc(OC)cc2OC)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL127783 | 25518 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 429 | 10 | 1 | 6 | 5.5 | CCCN(Cc1sc(Nc2ccc(OC)cc2OC)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 44392759 | 72015 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 393 | 7 | 0 | 4 | 5.5 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2c(C)c(C)c(C)c(C)c2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL182705 | 72015 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 393 | 7 | 0 | 4 | 5.5 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2c(C)c(C)c(C)c(C)c2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 10299169 | 139189 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 473 | 6 | 1 | 5 | 6.5 | COC[C@@H]1CCCN1Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL369754 | 139189 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 473 | 6 | 1 | 5 | 6.5 | COC[C@@H]1CCCN1Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 10297799 | 25702 | 0 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 451 | 9 | 1 | 6 | 4.9 | COCCN(CCOC)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL128566 | 25702 | 0 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 451 | 9 | 1 | 6 | 4.9 | COCCN(CCOC)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C | 10.1016/j.bmcl.2003.08.055 | |||
| 44305179 | 210144 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 322 | 6 | 0 | 4 | 4.6 | CCCCN(CC)c1cc(C)nc2c(-c3ccccc3)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| CHEMBL65195 | 210144 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 322 | 6 | 0 | 4 | 4.6 | CCCCN(CC)c1cc(C)nc2c(-c3ccccc3)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| 44460546 | 212116 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 416 | 7 | 1 | 3 | 6.2 | Cc1cc(F)ccc1C(Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| CHEMBL79576 | 212116 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 416 | 7 | 1 | 3 | 6.2 | Cc1cc(F)ccc1C(Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| 44460368 | 212430 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 490 | 6 | 2 | 3 | 6.8 | CC(=O)Nc1cccc(C(=O)C(Nc2ccc(Cl)cc2Cl)c2ccccc2Br)c1 | 10.1021/jm049974i | |||
| CHEMBL81912 | 212430 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 490 | 6 | 2 | 3 | 6.8 | CC(=O)Nc1cccc(C(=O)C(Nc2ccc(Cl)cc2Cl)c2ccccc2Br)c1 | 10.1021/jm049974i | |||
| 44407864 | 82183 | 0 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 394 | 4 | 1 | 4 | 5.5 | Cc1cccc(S(=O)(=O)c2c(C)cc(C)nc2Nc2c(C)cc(C)cc2C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL204014 | 82183 | 0 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 394 | 4 | 1 | 4 | 5.5 | Cc1cccc(S(=O)(=O)c2c(C)cc(C)nc2Nc2c(C)cc(C)cc2C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| 44341902 | 16940 | 1 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 348 | 7 | 0 | 3 | 5.8 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(OC)cc3)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL115928 | 16940 | 1 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 348 | 7 | 0 | 3 | 5.8 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(OC)cc3)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 11418006 | 82327 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 394 | 5 | 1 | 4 | 5.5 | CCc1ccc(S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL204481 | 82327 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 394 | 5 | 1 | 4 | 5.5 | CCc1ccc(S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2005.10.097 | |||
| 44446739 | 101424 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 488 | 10 | 0 | 5 | 6.1 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OCCN2CCN(C)CC2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL252493 | 101424 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 488 | 10 | 0 | 5 | 6.1 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OCCN2CCN(C)CC2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 11065415 | 210205 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 267 | 4 | 2 | 3 | 3.2 | CC(=O)/C(=N\c1ccccc1)NNc1ccccc1C | 10.1021/jm025512y | |||
| CHEMBL65708 | 210205 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 267 | 4 | 2 | 3 | 3.2 | CC(=O)/C(=N\c1ccccc1)NNc1ccccc1C | 10.1021/jm025512y | |||
| 11022343 | 210449 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 281 | 4 | 2 | 3 | 3.5 | CC(=O)/C(=N\c1cccc(C)c1)NNc1ccccc1C | 10.1021/jm025512y | |||
| CHEMBL67394 | 210449 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 281 | 4 | 2 | 3 | 3.5 | CC(=O)/C(=N\c1cccc(C)c1)NNc1ccccc1C | 10.1021/jm025512y | |||
| 20780067 | 74663 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 522 | 6 | 0 | 4 | 7.4 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CC4CCC4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL191052 | 74663 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 522 | 6 | 0 | 4 | 7.4 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CC4CCC4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| 21916146 | 13264 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 466 | 8 | 0 | 4 | 6.7 | CCCN(CCC1CC1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1082697 | 13264 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 466 | 8 | 0 | 4 | 6.7 | CCCN(CCC1CC1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 10410573 | 101155 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 432 | 9 | 1 | 6 | 5.5 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2cc(CC)ccn2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL250814 | 101155 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 432 | 9 | 1 | 6 | 5.5 | CCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2cc(CC)ccn2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| 44587492 | 200408 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 385 | 10 | 0 | 5 | 5.5 | CCCOc1nc(-c2c(C)cc(C)cc2OC)nc(C)c1N(CCC)CCC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL527030 | 200408 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 385 | 10 | 0 | 5 | 5.5 | CCCOc1nc(-c2c(C)cc(C)cc2OC)nc(C)c1N(CCC)CCC | 10.1016/j.bmcl.2008.07.063 | |||
| 22324332 | 113754 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 359 | 8 | 0 | 6 | 3.4 | CCCN(CCC)c1c(C)nc(-c2c(OC)cccc2OC)n(C)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL315112 | 113754 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 359 | 8 | 0 | 6 | 3.4 | CCCN(CCC)c1c(C)nc(-c2c(OC)cccc2OC)n(C)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 44392739 | 71465 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 353 | 6 | 1 | 6 | 4.0 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(O)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL181860 | 71465 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 353 | 6 | 1 | 6 | 4.0 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(O)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 44443595 | 179429 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 390 | 8 | 1 | 5 | 5.9 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1NC(c1ccccc1)C(C)C | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL449657 | 179429 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 390 | 8 | 1 | 5 | 5.9 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1NC(c1ccccc1)C(C)C | 10.1016/j.bmcl.2007.09.008 | |||
| 11046479 | 109891 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 355 | 4 | 2 | 3 | 4.8 | CC(=O)/C(=N\Nc1ccccc1C(F)(F)F)Nc1cccc(Cl)c1 | 10.1021/jm025512y | |||
| CHEMBL307751 | 109891 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 355 | 4 | 2 | 3 | 4.8 | CC(=O)/C(=N\Nc1ccccc1C(F)(F)F)Nc1cccc(Cl)c1 | 10.1021/jm025512y | |||
| 20780105 | 74798 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 558 | 8 | 0 | 4 | 7.8 | CC(C)c1ccc(-n2c3ccccc3n3c(CN(CC4CC4)CC4CC4)c(C(F)(F)F)nc23)c(Br)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL191366 | 74798 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 558 | 8 | 0 | 4 | 7.8 | CC(C)c1ccc(-n2c3ccccc3n3c(CN(CC4CC4)CC4CC4)c(C(F)(F)F)nc23)c(Br)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| 10708209 | 64286 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 284 | 4 | 0 | 4 | 3.6 | CCN(c1nc(C)cc(C)n1)c1ccc(N(C)C)cc1C | 10.1021/jm980222w | |||
| CHEMBL166110 | 64286 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 284 | 4 | 0 | 4 | 3.6 | CCN(c1nc(C)cc(C)n1)c1ccc(N(C)C)cc1C | 10.1021/jm980222w | |||
| 22249007 | 70772 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 5.9 | CCc1nc(NC(CC)CC)c(C)nc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| CHEMBL1807038 | 70772 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 5.9 | CCc1nc(NC(CC)CC)c(C)nc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| 18691311 | 11818 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 457 | 7 | 0 | 6 | 5.4 | CCN(c1nc(C)cc(-c2ccccc2OC)n1)c1c(Br)cc(OC)cc1OC | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL10526 | 11818 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 457 | 7 | 0 | 6 | 5.4 | CCN(c1nc(C)cc(-c2ccccc2OC)n1)c1c(Br)cc(OC)cc1OC | 10.1016/s0960-894x(99)00132-8 | |||
| 44392800 | 139182 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 355 | 7 | 1 | 5 | 3.5 | CCCN(CCO)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL369717 | 139182 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 355 | 7 | 1 | 5 | 3.5 | CCCN(CCO)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 22249074 | 70765 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 337 | 6 | 1 | 3 | 5.6 | CCc1nc(NC(CC)CC)cnc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| CHEMBL1807031 | 70765 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 337 | 6 | 1 | 3 | 5.6 | CCc1nc(NC(CC)CC)cnc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| 44460272 | 212476 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 442 | 7 | 1 | 3 | 6.2 | Cc1ccc(N[C@@H](C(=O)CCc2ccncc2)c2ccccc2Br)c(Cl)c1 | 10.1021/jm049974i | |||
| CHEMBL82308 | 212476 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 442 | 7 | 1 | 3 | 6.2 | Cc1ccc(N[C@@H](C(=O)CCc2ccncc2)c2ccccc2Br)c(Cl)c1 | 10.1021/jm049974i | |||
| 44443630 | 161507 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 5.2 | CCO[C@H]1Cc2ccccc2[C@@H]1Nc1nc(CC)c(Oc2cc(C)ccn2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL399877 | 161507 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 5.2 | CCO[C@H]1Cc2ccccc2[C@@H]1Nc1nc(CC)c(Oc2cc(C)ccn2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| 44392691 | 73077 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 379 | 8 | 0 | 4 | 5.1 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1CC | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL184851 | 73077 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 379 | 8 | 0 | 4 | 5.1 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1CC | 10.1016/j.bmcl.2004.05.072 | |||
| 11156095 | 75749 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 377 | 7 | 0 | 4 | 5.7 | CCCC(CCC)N1CCc2cn(-c3ccccc3OC)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL192288 | 75749 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 377 | 7 | 0 | 4 | 5.7 | CCCC(CCC)N1CCc2cn(-c3ccccc3OC)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 10835652 | 125955 | 0 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 415 | 7 | 2 | 5 | 5.7 | CCc1cccc(CC)c1Nc1nc(C)nc(NCc2ccc(C(F)(F)F)cc2)n1 | 10.1021/jm960148m | |||
| CHEMBL343073 | 125955 | 0 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 415 | 7 | 2 | 5 | 5.7 | CCc1cccc(CC)c1Nc1nc(C)nc(NCc2ccc(C(F)(F)F)cc2)n1 | 10.1021/jm960148m | |||
| 44389084 | 129094 | 0 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 443 | 4 | 1 | 4 | 6.9 | FC(F)(F)c1nc(Nc2c(Cl)cc(Cl)cc2Cl)sc1CN1CCCCC1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL359828 | 129094 | 0 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 443 | 4 | 1 | 4 | 6.9 | FC(F)(F)c1nc(Nc2c(Cl)cc(Cl)cc2Cl)sc1CN1CCCCC1 | 10.1016/j.bmcl.2004.10.055 | |||
| 10164848 | 28250 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 517 | 10 | 0 | 4 | 7.8 | CCCN(Cc1sc(N(CC)c2ccc(C(C)C)cc2Br)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL131571 | 28250 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 517 | 10 | 0 | 4 | 7.8 | CCCN(Cc1sc(N(CC)c2ccc(C(C)C)cc2Br)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 3495 | 7958 | 28 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/s0960-894x(98)00372-2 | |||
| 5311055 | 7958 | 28 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/s0960-894x(98)00372-2 | |||
| CHEMBL9946 | 7958 | 28 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 364 | 6 | 0 | 4 | 5.6 | CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC | 10.1016/s0960-894x(98)00372-2 | |||
| 136029158 | 212449 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 357 | 8 | 1 | 5 | 4.7 | CCCN(CCC)c1c(O)nc(-c2c(C)cc(C)cc2OC)nc1CC | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL82112 | 212449 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 357 | 8 | 1 | 5 | 4.7 | CCCN(CCC)c1c(O)nc(-c2c(C)cc(C)cc2OC)nc1CC | 10.1016/s0960-894x(03)00483-9 | |||
| 44392751 | 128834 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 397 | 10 | 0 | 6 | 4.5 | C=C(c1cc(N(CCC)CC2CC2)nc(C)n1)c1c(OC)cc(OC)cc1OC | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL359636 | 128834 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 397 | 10 | 0 | 6 | 4.5 | C=C(c1cc(N(CCC)CC2CC2)nc(C)n1)c1c(OC)cc(OC)cc1OC | 10.1016/j.bmcl.2004.05.072 | |||
| 10206904 | 129544 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 493 | 7 | 1 | 4 | 7.5 | CN(CCc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL360471 | 129544 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 493 | 7 | 1 | 4 | 7.5 | CN(CCc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 21916237 | 100135 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 441 | 8 | 1 | 7 | 4.0 | COCC(COC)NCc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL245506 | 100135 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 441 | 8 | 1 | 7 | 4.0 | COCC(COC)NCc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 44308134 | 210341 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 460 | 7 | 0 | 6 | 5.3 | CCCN(CCN1CCCCC1)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL66671 | 210341 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 460 | 7 | 0 | 6 | 5.3 | CCCN(CCN1CCCCC1)c1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 44587452 | 194925 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 327 | 7 | 0 | 4 | 4.7 | CCCN(CCC)c1cnc(-c2c(C)cc(C)cc2OC)nc1C | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL498480 | 194925 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 327 | 7 | 0 | 4 | 4.7 | CCCN(CCC)c1cnc(-c2c(C)cc(C)cc2OC)nc1C | 10.1016/j.bmcl.2008.07.063 | |||
| 9797993 | 109757 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 339 | 7 | 1 | 5 | 4.5 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960149e | |||
| CHEMBL306618 | 109757 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 339 | 7 | 1 | 5 | 4.5 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960149e | |||
| 9797993 | 109757 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 339 | 7 | 1 | 5 | 4.5 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960148m | |||
| CHEMBL306618 | 109757 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 339 | 7 | 1 | 5 | 4.5 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm960148m | |||
| 9797993 | 109757 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 339 | 7 | 1 | 5 | 4.5 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm9900117 | |||
| CHEMBL306618 | 109757 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 339 | 7 | 1 | 5 | 4.5 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1 | 10.1021/jm9900117 | |||
| 18672241 | 71140 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 455 | 8 | 1 | 4 | 7.0 | C=CCN(CC=C)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181280 | 71140 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 455 | 8 | 1 | 4 | 7.0 | C=CCN(CC=C)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 20780125 | 130652 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 442 | 7 | 0 | 4 | 6.0 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL362706 | 130652 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 442 | 7 | 0 | 4 | 6.0 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 20780058 | 100103 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 458 | 6 | 0 | 6 | 5.3 | Cc1cc(C)c(-n2c3ncccc3n3c(CN(C)CCc4cccnc4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL245297 | 100103 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 458 | 6 | 0 | 6 | 5.3 | Cc1cc(C)c(-n2c3ncccc3n3c(CN(C)CCc4cccnc4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| 10062901 | 177023 | 1 | None | - | 1 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 291 | 2 | 0 | 3 | 3.6 | Cc1cc(C)nc(N(C)c2ccccc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL444577 | 177023 | 1 | None | - | 1 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 291 | 2 | 0 | 3 | 3.6 | Cc1cc(C)nc(N(C)c2ccccc2Br)n1 | 10.1021/jm980222w | |||
| 10783164 | 33831 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 337 | 9 | 1 | 5 | 4.2 | C=CCN(CC=C)c1nc(C)nc(Nc2c(CC)cccc2CC)n1 | 10.1021/jm960148m | |||
| CHEMBL136519 | 33831 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 337 | 9 | 1 | 5 | 4.2 | C=CCN(CC=C)c1nc(C)nc(Nc2c(CC)cccc2CC)n1 | 10.1021/jm960148m | |||
| 20780072 | 74000 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 476 | 5 | 0 | 4 | 6.9 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(C)Cc4ccccc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL187924 | 74000 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 476 | 5 | 0 | 4 | 6.9 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(C)Cc4ccccc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| 11268730 | 168623 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 370 | 4 | 0 | 5 | 4.2 | CCC(CC)N1CCn2c(=O)n(-c3ccc(Cl)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL414664 | 168623 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 370 | 4 | 0 | 5 | 4.2 | CCC(CC)N1CCn2c(=O)n(-c3ccc(Cl)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 44392764 | 71973 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 353 | 7 | 0 | 4 | 4.9 | CCCN(CCC)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL182504 | 71973 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 353 | 7 | 0 | 4 | 4.9 | CCCN(CCC)c1nc(C)nc(C(=O)c2c(C)cc(C)cc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 44443650 | 100806 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 446 | 9 | 1 | 6 | 5.9 | CCCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2cc(C)cc(C)n2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL248803 | 100806 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 446 | 9 | 1 | 6 | 5.9 | CCCO[C@H]1Cc2ccccc2[C@H]1Nc1nc(CC)c(Oc2cc(C)cc(C)n2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| 11364104 | 82380 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 502 | 8 | 1 | 6 | 6.5 | COc1cccc(COc2ccc(S(=O)(=O)c3ccc(C)nc3Nc3c(C)cc(C)cc3C)cc2)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL204690 | 82380 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 502 | 8 | 1 | 6 | 6.5 | COc1cccc(COc2ccc(S(=O)(=O)c3ccc(C)nc3Nc3c(C)cc(C)cc3C)cc2)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| 21916273 | 13739 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 542 | 6 | 0 | 4 | 8.1 | CCN(Cc1ccc(Cl)c(Cl)c1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1084565 | 13739 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 542 | 6 | 0 | 4 | 8.1 | CCN(Cc1ccc(Cl)c(Cl)c1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 20780049 | 155617 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 469 | 4 | 0 | 5 | 6.6 | Cc1cc(C)c(-n2c3ncccc3n3c(CN4CCCC4c4ccccc4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL394112 | 155617 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 469 | 4 | 0 | 5 | 6.6 | Cc1cc(C)c(-n2c3ncccc3n3c(CN4CCCC4c4ccccc4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| 46891010 | 13208 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 438 | 3 | 0 | 4 | 6.0 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCCC(C)C4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1082443 | 13208 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 438 | 3 | 0 | 4 | 6.0 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCCC(C)C4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 21916154 | 129355 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 432 | 7 | 0 | 4 | 6.3 | CCCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ccc(F)cc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL360185 | 129355 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 432 | 7 | 0 | 4 | 6.3 | CCCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ccc(F)cc3n12)CC1CC1 | 10.1016/j.bmcl.2005.06.028 | |||
| 44341755 | 16926 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 412 | 9 | 0 | 4 | 6.8 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(C)cc3Cl)n(CC)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL115818 | 16926 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 412 | 9 | 0 | 4 | 6.8 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(C)cc3Cl)n(CC)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 122193724 | 130667 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 448 | 5 | 0 | 4 | 4.8 | Cc1cc(N(C)C)c2c(n1)N(c1ccc(C(C)C)cc1Br)CC(=O)N2CCF | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3627731 | 130667 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 448 | 5 | 0 | 4 | 4.8 | Cc1cc(N(C)C)c2c(n1)N(c1ccc(C(C)C)cc1Br)CC(=O)N2CCF | 10.1016/j.bmcl.2015.10.010 | |||
| 44443591 | 101107 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 376 | 8 | 1 | 5 | 5.7 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1NC(CC)c1ccccc1 | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL250617 | 101107 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 376 | 8 | 1 | 5 | 5.7 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1NC(CC)c1ccccc1 | 10.1016/j.bmcl.2007.09.008 | |||
| 10831985 | 127256 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 354 | 6 | 1 | 7 | 3.3 | CCC(COC)Nc1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL354256 | 127256 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 354 | 6 | 1 | 7 | 3.3 | CCC(COC)Nc1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| 10788999 | 64279 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 435 | 9 | 0 | 7 | 4.6 | CCCCN(CC#N)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C(F)(F)F)n1 | 10.1021/jm980222w | |||
| CHEMBL166056 | 64279 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 435 | 9 | 0 | 7 | 4.6 | CCCCN(CC#N)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C(F)(F)F)n1 | 10.1021/jm980222w | |||
| 10764802 | 65491 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 424 | 9 | 0 | 6 | 5.0 | CCCN(CCC)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C(F)(F)F)n1 | 10.1021/jm980222w | |||
| CHEMBL168497 | 65491 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 424 | 9 | 0 | 6 | 5.0 | CCCN(CCC)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C(F)(F)F)n1 | 10.1021/jm980222w | |||
| 10549365 | 172474 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 406 | 7 | 0 | 6 | 4.0 | CCN(CC)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL424538 | 172474 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 406 | 7 | 0 | 6 | 4.0 | CCN(CC)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 10228129 | 14171 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 488 | 7 | 0 | 4 | 6.8 | CCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1086504 | 14171 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 488 | 7 | 0 | 4 | 6.8 | CCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 21916331 | 154267 | 1 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 449 | 7 | 0 | 5 | 6.3 | CCCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12)CC1CCC1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL393044 | 154267 | 1 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 449 | 7 | 0 | 5 | 6.3 | CCCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12)CC1CCC1 | 10.1016/j.bmcl.2007.01.008 | |||
| 44446725 | 175732 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 376 | 7 | 0 | 3 | 6.5 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL438888 | 175732 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 376 | 7 | 0 | 3 | 6.5 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 44446725 | 175732 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 376 | 7 | 0 | 3 | 6.5 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL438888 | 175732 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 376 | 7 | 0 | 3 | 6.5 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2008.07.063 | |||
| 44587455 | 194826 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 465 | 8 | 0 | 5 | 6.1 | CCCN(CCC)c1c(C)nc(-c2c(OC)cc(C(F)(F)F)cc2C(F)(F)F)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL497651 | 194826 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 465 | 8 | 0 | 5 | 6.1 | CCCN(CCC)c1c(C)nc(-c2c(OC)cc(C(F)(F)F)cc2C(F)(F)F)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| 11166919 | 173087 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 417 | 5 | 0 | 4 | 6.1 | CCC(CC)N1CCc2cn(-c3ccc(OC(F)(F)F)cc3C)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL427168 | 173087 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 417 | 5 | 0 | 4 | 6.1 | CCC(CC)N1CCc2cn(-c3ccc(OC(F)(F)F)cc3C)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 44384801 | 139051 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 393 | 6 | 0 | 6 | 4.0 | CCCN(CC1CC1)c1nc(C)nc2c1n(C)c(=O)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL369700 | 139051 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 393 | 6 | 0 | 6 | 4.0 | CCCN(CC1CC1)c1nc(C)nc2c1n(C)c(=O)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00108-0 | |||
| 11798114 | 65581 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 457 | 9 | 0 | 5 | 6.4 | CCCCN(CCCC)c1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL168823 | 65581 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 457 | 9 | 0 | 5 | 6.4 | CCCCN(CCCC)c1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 9910700 | 65819 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 432 | 7 | 1 | 7 | 4.2 | CCC(COC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169416 | 65819 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 432 | 7 | 1 | 7 | 4.2 | CCC(COC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 10295219 | 70787 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 413 | 9 | 1 | 6 | 5.2 | CCc1nc(-c2ccc(OC(F)(F)F)cc2OC)c(OC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1807057 | 70787 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 413 | 9 | 1 | 6 | 5.2 | CCc1nc(-c2ccc(OC(F)(F)F)cc2OC)c(OC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 10303191 | 176054 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 561 | 8 | 1 | 4 | 8.8 | FC(F)(F)CCN(Cc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL441311 | 176054 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 561 | 8 | 1 | 4 | 8.8 | FC(F)(F)CCN(Cc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 44392781 | 136449 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 371 | 6 | 0 | 5 | 5.0 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(C)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL367371 | 136449 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 371 | 6 | 0 | 5 | 5.0 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(C)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 10789145 | 39865 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 437 | 9 | 1 | 7 | 4.6 | CCOCC(COCC)Nc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| CHEMBL141692 | 39865 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 437 | 9 | 1 | 7 | 4.6 | CCOCC(COCC)Nc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1021/jm9904351 | |||
| 10142098 | 13263 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 506 | 7 | 0 | 4 | 6.9 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCC4CC4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1082696 | 13263 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 506 | 7 | 0 | 4 | 6.9 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(CCC4CC4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 11212114 | 113168 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 412 | 9 | 0 | 5 | 5.9 | CCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL3085416 | 113168 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 412 | 9 | 0 | 5 | 5.9 | CCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL3139409 | 113168 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 412 | 9 | 0 | 5 | 5.9 | CCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 11576870 | 77347 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 380 | 4 | 0 | 4 | 5.4 | CC[C@H]1Cn2nc(-c3ccc(C)cc3Cl)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL194890 | 77347 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 380 | 4 | 0 | 4 | 5.4 | CC[C@H]1Cn2nc(-c3ccc(C)cc3Cl)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 11634953 | 78692 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 402 | 5 | 0 | 4 | 6.1 | CCCCN1c2cc(C)nc3c(-c4ccc(Cl)cc4Cl)nn(c23)C[C@@H]1CC | 10.1021/jm049085v | |||
| CHEMBL197197 | 78692 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 402 | 5 | 0 | 4 | 6.1 | CCCCN1c2cc(C)nc3c(-c4ccc(Cl)cc4Cl)nn(c23)C[C@@H]1CC | 10.1021/jm049085v | |||
| 44305255 | 109531 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 416 | 4 | 0 | 4 | 6.5 | CCCC1CCCCN1c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| CHEMBL305092 | 109531 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 416 | 4 | 0 | 4 | 6.5 | CCCC1CCCCN1c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| 21916296 | 153784 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 471 | 7 | 0 | 5 | 6.3 | CCN(CCc1ccccc1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL392655 | 153784 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 471 | 7 | 0 | 5 | 6.3 | CCN(CCc1ccccc1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 44342084 | 16798 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 392 | 8 | 0 | 4 | 5.2 | COCCN(CCOC)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL115032 | 16798 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 392 | 8 | 0 | 4 | 5.2 | COCCN(CCOC)c1cc(C)nc2c(-c3c(C)cc(C)cc3C)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 44396572 | 130166 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 444 | 8 | 1 | 7 | 4.5 | COCC(Cc1ccccc1)Nc1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL361670 | 130166 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 444 | 8 | 1 | 7 | 4.5 | COCC(Cc1ccccc1)Nc1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 11477320 | 77704 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 391 | 7 | 0 | 4 | 6.0 | CCCC(CCC)N1CCc2cn(-c3ccc(OC)cc3C)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL195152 | 77704 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 391 | 7 | 0 | 4 | 6.0 | CCCC(CCC)N1CCc2cn(-c3ccc(OC)cc3C)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 9849255 | 202687 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 510 | 9 | 0 | 8 | 5.5 | COCCN(CCOC)c1nc(C)nc2c1sc(=S)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00159-6 | |||
| CHEMBL559127 | 202687 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 510 | 9 | 0 | 8 | 5.5 | COCCN(CCOC)c1nc(C)nc2c1sc(=S)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00159-6 | |||
| 44392805 | 71651 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 463 | 6 | 0 | 5 | 4.9 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(I)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL182165 | 71651 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 463 | 6 | 0 | 5 | 4.9 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(I)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 44392643 | 71343 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 371 | 6 | 0 | 5 | 5.0 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(Cl)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL181548 | 71343 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 371 | 6 | 0 | 5 | 5.0 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(Cl)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 10672237 | 65485 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 475 | 9 | 0 | 7 | 4.4 | COCCN(CCOC)c1nc(C)nc2c1nc(C)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL168476 | 65485 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 475 | 9 | 0 | 7 | 4.4 | COCCN(CCOC)c1nc(C)nc2c1nc(C)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44341816 | 16325 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 434 | 9 | 0 | 5 | 5.9 | CCCCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL112336 | 16325 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 434 | 9 | 0 | 5 | 5.9 | CCCCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 11339333 | 69851 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 426 | 10 | 0 | 5 | 6.3 | CCCCC(c1ccccc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL178836 | 69851 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 426 | 10 | 0 | 5 | 6.3 | CCCCC(c1ccccc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 44388403 | 172963 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 406 | 10 | 0 | 5 | 5.9 | CCCCC(c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL426419 | 172963 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 406 | 10 | 0 | 5 | 5.9 | CCCCC(c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| 44352448 | 25736 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 411 | 8 | 1 | 4 | 6.5 | CCCN(Cc1sc(Nc2c(C)cc(C)cc2C)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL128713 | 25736 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 411 | 8 | 1 | 4 | 6.5 | CCCN(Cc1sc(Nc2c(C)cc(C)cc2C)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 11188634 | 132733 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 395 | 7 | 0 | 7 | 3.7 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(OC)nc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL364892 | 132733 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 395 | 7 | 0 | 7 | 3.7 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(OC)nc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 10662222 | 65279 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 303 | 5 | 0 | 5 | 4.0 | CCN(c1nc(C)cc(C)n1)c1ccc(OC)cc1SC | 10.1021/jm980222w | |||
| CHEMBL168359 | 65279 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 303 | 5 | 0 | 5 | 4.0 | CCN(c1nc(C)cc(C)n1)c1ccc(OC)cc1SC | 10.1021/jm980222w | |||
| 9951620 | 16353 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 5.8 | CCCCN(CC)c1cc(C)[nH]c2c(-c3ccc(Cl)cc3Cl)nnc1-2 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL112478 | 16353 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 5.8 | CCCCN(CC)c1cc(C)[nH]c2c(-c3ccc(Cl)cc3Cl)nnc1-2 | 10.1016/s0960-894x(03)00621-8 | |||
| 44587454 | 199941 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.7 | CCCN(CCC)c1c(CC(C)(C)O)nc(-c2c(C)cc(C)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL523074 | 199941 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.7 | CCCN(CCC)c1c(CC(C)(C)O)nc(-c2c(C)cc(C)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| 20780008 | 14121 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 412 | 6 | 0 | 4 | 5.3 | CCCN(CC1CC1)C(=O)c1c(C)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1086259 | 14121 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 412 | 6 | 0 | 4 | 5.3 | CCCN(CC1CC1)C(=O)c1c(C)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 20780037 | 138571 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 422 | 6 | 0 | 4 | 4.9 | CCCN(CC(F)(F)F)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL369341 | 138571 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 422 | 6 | 0 | 4 | 4.9 | CCCN(CC(F)(F)F)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 44388393 | 67327 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 392 | 9 | 0 | 5 | 5.6 | CCCC(c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL175902 | 67327 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 392 | 9 | 0 | 5 | 5.6 | CCCC(c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| 21916323 | 13862 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 486 | 4 | 0 | 4 | 6.7 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCC(c5ccccc5)C4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1085088 | 13862 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 486 | 4 | 0 | 4 | 6.7 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCC(c5ccccc5)C4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 20780251 | 71142 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 394 | 7 | 0 | 4 | 4.8 | CCc1nc2n(c1C(=O)N(CC)CCC1CC1)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL181287 | 71142 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 394 | 7 | 0 | 4 | 4.8 | CCc1nc2n(c1C(=O)N(CC)CCC1CC1)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 20780070 | 134067 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 572 | 8 | 0 | 4 | 8.2 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCc4ccccc4)CCC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL365858 | 134067 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 572 | 8 | 0 | 4 | 8.2 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCc4ccccc4)CCC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| 11077161 | 210269 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 291 | 4 | 2 | 3 | 3.2 | C#Cc1cccc(/N=C(/NNc2ccccc2C)C(C)=O)c1 | 10.1021/jm025512y | |||
| CHEMBL66157 | 210269 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 291 | 4 | 2 | 3 | 3.2 | C#Cc1cccc(/N=C(/NNc2ccccc2C)C(C)=O)c1 | 10.1021/jm025512y | |||
| 9865345 | 16231 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 392 | 6 | 2 | 5 | 4.8 | CCCC(CO)Nc1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL111867 | 16231 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 392 | 6 | 2 | 5 | 4.8 | CCCC(CO)Nc1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 44307655 | 210465 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 393 | 8 | 0 | 5 | 5.8 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(C)cc3C)nn(CCC)c12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL67483 | 210465 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 393 | 8 | 0 | 5 | 5.8 | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(C)cc3C)nn(CCC)c12 | 10.1016/s0960-894x(02)00358-x | |||
| 11222685 | 75782 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 378 | 4 | 0 | 4 | 5.4 | CCC(CC)N1CCc2cn(-c3ccc(Cl)cc3C#N)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL192335 | 75782 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 378 | 4 | 0 | 4 | 5.4 | CCC(CC)N1CCc2cn(-c3ccc(Cl)cc3C#N)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| 44462209 | 112966 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 409 | 10 | 0 | 6 | 4.5 | CCCN(CCC)c1c(C)nc(-c2c(OC)cccc2OC(F)F)n(CC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL313823 | 112966 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 409 | 10 | 0 | 6 | 4.5 | CCCN(CCC)c1c(C)nc(-c2c(OC)cccc2OC(F)F)n(CC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 10857993 | 210342 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 253 | 4 | 2 | 3 | 2.9 | CC(=O)/C(=N\c1ccccc1)NNc1ccccc1 | 10.1021/jm025512y | |||
| CHEMBL66698 | 210342 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 253 | 4 | 2 | 3 | 2.9 | CC(=O)/C(=N\c1ccccc1)NNc1ccccc1 | 10.1021/jm025512y | |||
| 44306462 | 209820 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 385 | 9 | 0 | 5 | 4.7 | CCCN(c1nccc(-c2c(F)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL63457 | 209820 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 385 | 9 | 0 | 5 | 4.7 | CCCN(c1nccc(-c2c(F)cc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| 44306162 | 210286 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 413 | 7 | 0 | 3 | 5.9 | CCCN(c1ncc(C)c(-c2ccc(Br)cc2C)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL66249 | 210286 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 413 | 7 | 0 | 3 | 5.9 | CCCN(c1ncc(C)c(-c2ccc(Br)cc2C)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| 10549990 | 174849 | 0 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 418 | 5 | 0 | 5 | 4.7 | CCN(c1nc(C)cc(N2CCOCC2)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm990590f | |||
| CHEMBL432496 | 174849 | 0 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 418 | 5 | 0 | 5 | 4.7 | CCN(c1nc(C)cc(N2CCOCC2)n1)c1ccc(C(C)C)cc1Br | 10.1021/jm990590f | |||
| 20780280 | 71120 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 484 | 7 | 0 | 4 | 5.6 | CCc1nc2n(c1C(=O)N(CC1CC1)CC(F)(F)C(F)(F)F)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL181227 | 71120 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 484 | 7 | 0 | 4 | 5.6 | CCc1nc2n(c1C(=O)N(CC1CC1)CC(F)(F)C(F)(F)F)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 21916183 | 14353 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 476 | 7 | 0 | 4 | 6.5 | CCCN(CCC(F)(F)F)Cc1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1087804 | 14353 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 476 | 7 | 0 | 4 | 6.5 | CCCN(CCC(F)(F)F)Cc1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| 11653680 | 78228 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 374 | 3 | 0 | 4 | 5.3 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1CC | 10.1021/jm049085v | |||
| CHEMBL196146 | 78228 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 374 | 3 | 0 | 4 | 5.3 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1CC | 10.1021/jm049085v | |||
| 9887524 | 172937 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 404 | 5 | 0 | 5 | 5.0 | CCC(COC)N1CCn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc1c32 | 10.1021/jm049085v | |||
| CHEMBL426283 | 172937 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 404 | 5 | 0 | 5 | 5.0 | CCC(COC)N1CCn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc1c32 | 10.1021/jm049085v | |||
| 44392758 | 71972 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 399 | 10 | 0 | 7 | 3.7 | CCCN(CC1CC1)c1cc(C)nc(C(=O)c2c(OC)cc(OC)cc2OC)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL182500 | 71972 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 399 | 10 | 0 | 7 | 3.7 | CCCN(CC1CC1)c1cc(C)nc(C(=O)c2c(OC)cc(OC)cc2OC)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| 10118581 | 70115 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 513 | 8 | 1 | 4 | 8.7 | CCCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CCCCC1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL179416 | 70115 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 513 | 8 | 1 | 4 | 8.7 | CCCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CCCCC1 | 10.1016/j.bmcl.2004.10.055 | |||
| 11374322 | 142495 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 449 | 8 | 1 | 6 | 5.6 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCCCC#N)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL372996 | 142495 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 449 | 8 | 1 | 6 | 5.6 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCCCC#N)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| 10575478 | 175176 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 448 | 8 | 1 | 8 | 2.9 | COCCN(CCO)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL434689 | 175176 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 448 | 8 | 1 | 8 | 2.9 | COCCN(CCO)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44341734 | 16990 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 446 | 10 | 0 | 4 | 7.5 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(CCC)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL116010 | 16990 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 446 | 10 | 0 | 4 | 7.5 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(CCC)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 44317977 | 212010 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 6.1 | Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2C)c(C(F)(F)F)c1 | 10.1021/jm049974i | |||
| CHEMBL78721 | 212010 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 412 | 7 | 1 | 3 | 6.1 | Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2C)c(C(F)(F)F)c1 | 10.1021/jm049974i | |||
| 11792386 | 64331 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 353 | 6 | 0 | 7 | 3.5 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1c(C)cc(C)nc1C | 10.1021/jm980224g | |||
| CHEMBL166431 | 64331 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 353 | 6 | 0 | 7 | 3.5 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1c(C)cc(C)nc1C | 10.1021/jm980224g | |||
| 44307784 | 210859 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 293 | 4 | 1 | 5 | 3.3 | CC(=O)/C(=N\Nc1ccccc1C#N)Oc1cccc(C)c1 | 10.1021/jm025512y | |||
| CHEMBL70143 | 210859 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 293 | 4 | 1 | 5 | 3.3 | CC(=O)/C(=N\Nc1ccccc1C#N)Oc1cccc(C)c1 | 10.1021/jm025512y | |||
| 20780249 | 71431 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 462 | 8 | 0 | 4 | 5.7 | CCc1nc2n(c1C(=O)N(CCC1CC1)CCC(F)(F)F)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL181823 | 71431 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 462 | 8 | 0 | 4 | 5.7 | CCc1nc2n(c1C(=O)N(CCC1CC1)CCC(F)(F)F)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 11034476 | 210582 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 317 | 5 | 2 | 4 | 3.8 | COc1cccc(N/C(=N/Nc2ccccc2Cl)C(C)=O)c1 | 10.1021/jm025512y | |||
| CHEMBL68340 | 210582 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 317 | 5 | 2 | 4 | 3.8 | COc1cccc(N/C(=N/Nc2ccccc2Cl)C(C)=O)c1 | 10.1021/jm025512y | |||
| 20780069 | 74203 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 522 | 7 | 0 | 4 | 7.4 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCC4CC4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL188945 | 74203 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 522 | 7 | 0 | 4 | 7.4 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCC4CC4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| 11759733 | 210455 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 345 | 4 | 2 | 3 | 3.9 | C#Cc1cccc(/N=C(/NNc2ccccc2C(F)(F)F)C(C)=O)c1 | 10.1021/jm025512y | |||
| CHEMBL67438 | 210455 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 345 | 4 | 2 | 3 | 3.9 | C#Cc1cccc(/N=C(/NNc2ccccc2C(F)(F)F)C(C)=O)c1 | 10.1021/jm025512y | |||
| 10528613 | 65785 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 476 | 10 | 0 | 8 | 3.9 | COCCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169195 | 65785 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 476 | 10 | 0 | 8 | 3.9 | COCCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 20780271 | 128807 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 484 | 7 | 0 | 4 | 6.1 | CCc1nc2n(c1C(=O)N(CCC(F)(F)F)Cc1ccccc1)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL359499 | 128807 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 484 | 7 | 0 | 4 | 6.1 | CCc1nc2n(c1C(=O)N(CCC(F)(F)F)Cc1ccccc1)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 20780285 | 130689 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 366 | 7 | 0 | 4 | 4.9 | CCCN(Cc1c(C)nc2n1CCN2c1c(C)cc(C)cc1C)CC1CC1 | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL362799 | 130689 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 366 | 7 | 0 | 4 | 4.9 | CCCN(Cc1c(C)nc2n1CCN2c1c(C)cc(C)cc1C)CC1CC1 | 10.1016/j.bmcl.2005.05.117 | |||
| 44266401 | 11693 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.7 | CCN(c1nc(C)cc(-c2ccccc2-c2nn[nH]n2)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL10464 | 11693 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.7 | CCN(c1nc(C)cc(-c2ccccc2-c2nn[nH]n2)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 10204820 | 122143 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 459 | 9 | 0 | 4 | 7.2 | CCCN(Cc1sc(N(CC)c2c(C)cc(C)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL334976 | 122143 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 459 | 9 | 0 | 4 | 7.2 | CCCN(Cc1sc(N(CC)c2c(C)cc(C)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 10832559 | 127202 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 362 | 2 | 0 | 2 | 5.9 | Cc1cc(Cl)c2ccn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| CHEMBL353774 | 127202 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 362 | 2 | 0 | 2 | 5.9 | Cc1cc(Cl)c2ccn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| 21916268 | 13950 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 438 | 6 | 0 | 4 | 6.1 | C=C(C)CN(CC)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1085518 | 13950 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 438 | 6 | 0 | 4 | 6.1 | C=C(C)CN(CC)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 44443643 | 101156 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 458 | 8 | 1 | 6 | 6.1 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OC1CCCC1 | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL250815 | 101156 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 458 | 8 | 1 | 6 | 6.1 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OC1CCCC1 | 10.1016/j.bmcl.2007.09.008 | |||
| 21916073 | 14451 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 484 | 8 | 0 | 4 | 6.8 | CCCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1088626 | 14451 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 484 | 8 | 0 | 4 | 6.8 | CCCN(CCc1ccccc1)Cc1c(C(F)(F)F)nc2n1CCCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2010.01.127 | |||
| 10113422 | 71094 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 427 | 4 | 1 | 4 | 6.2 | FC(F)(F)c1nc(Nc2c(Cl)cc(Cl)cc2Cl)sc1CN1CC=CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181121 | 71094 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 427 | 4 | 1 | 4 | 6.2 | FC(F)(F)c1nc(Nc2c(Cl)cc(Cl)cc2Cl)sc1CN1CC=CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| 20780167 | 131255 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 510 | 7 | 0 | 4 | 7.4 | CCCN(CCC(F)(F)F)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL364002 | 131255 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 510 | 7 | 0 | 4 | 7.4 | CCCN(CCC(F)(F)F)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 10664736 | 64285 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 338 | 4 | 0 | 4 | 4.3 | CCN(c1nc(C)cc(C)n1)c1ccc(N(C)C)cc1C(F)(F)F | 10.1021/jm980222w | |||
| CHEMBL166109 | 64285 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 338 | 4 | 0 | 4 | 4.3 | CCN(c1nc(C)cc(C)n1)c1ccc(N(C)C)cc1C(F)(F)F | 10.1021/jm980222w | |||
| 9803991 | 175463 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 453 | 7 | 0 | 5 | 6.5 | CCCCN(Cc1ccncc1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL436564 | 175463 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 453 | 7 | 0 | 5 | 6.5 | CCCCN(Cc1ccncc1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 20780287 | 69282 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 406 | 7 | 0 | 4 | 4.8 | CCc1nc2n(c1C(=O)N(CC1CC1)CC1CC1)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL178165 | 69282 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 406 | 7 | 0 | 4 | 4.8 | CCc1nc2n(c1C(=O)N(CC1CC1)CC1CC1)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 53309402 | 70764 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 364 | 7 | 0 | 2 | 6.6 | CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1CC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1807030 | 70764 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 364 | 7 | 0 | 2 | 6.6 | CCc1nc(-c2ccc(Cl)cc2Cl)c(CC)nc1CC(CC)CC | 10.1021/jm200365y | |||
| 12982784 | 22270 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 322 | 6 | 0 | 4 | 4.6 | CCCN(CCC)c1cc(C)nc2c(-c3ccccc3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL121614 | 22270 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 322 | 6 | 0 | 4 | 4.6 | CCCN(CCC)c1cc(C)nc2c(-c3ccccc3)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 21916111 | 13262 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 440 | 7 | 0 | 4 | 6.3 | CCCN(CCC)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1082686 | 13262 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 440 | 7 | 0 | 4 | 6.3 | CCCN(CCC)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 44305545 | 107481 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 5.5 | CCCCNc1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| CHEMBL292484 | 107481 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 5.5 | CCCCNc1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| 10739909 | 127355 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 402 | 6 | 1 | 6 | 4.6 | CCCCNc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL354579 | 127355 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 402 | 6 | 1 | 6 | 4.6 | CCCCNc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 11450550 | 136911 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 336 | 7 | 0 | 5 | 4.2 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)C(C)CC | 10.1021/jm049339c | |||
| CHEMBL367789 | 136911 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 336 | 7 | 0 | 5 | 4.2 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)C(C)CC | 10.1021/jm049339c | |||
| 10991736 | 210514 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 351 | 5 | 2 | 4 | 4.1 | COc1cccc(N/C(=N/Nc2ccccc2C(F)(F)F)C(C)=O)c1 | 10.1021/jm025512y | |||
| CHEMBL67785 | 210514 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 351 | 5 | 2 | 4 | 4.1 | COc1cccc(N/C(=N/Nc2ccccc2C(F)(F)F)C(C)=O)c1 | 10.1021/jm025512y | |||
| 44385629 | 68071 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 413 | 8 | 0 | 8 | 2.5 | COCCN(CCOC)c1nc(C)nc2c1n(C)c(=O)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL176707 | 68071 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 413 | 8 | 0 | 8 | 2.5 | COCCN(CCOC)c1nc(C)nc2c1n(C)c(=O)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00108-0 | |||
| 44462088 | 212688 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 371 | 8 | 0 | 5 | 4.3 | CCCN(CCC)c1c(CC)nc(-c2c(C)cc(C)cc2OC)n(C)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL84007 | 212688 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 371 | 8 | 0 | 5 | 4.3 | CCCN(CCC)c1c(CC)nc(-c2c(C)cc(C)cc2OC)n(C)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 10500067 | 64609 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 381 | 9 | 0 | 7 | 3.8 | CCCN(CCC#N)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C)n1 | 10.1021/jm980222w | |||
| CHEMBL167095 | 64609 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 381 | 9 | 0 | 7 | 3.8 | CCCN(CCC#N)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C)n1 | 10.1021/jm980222w | |||
| 10832987 | 64942 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 370 | 9 | 0 | 6 | 4.3 | CCCN(CCC)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C)n1 | 10.1021/jm980222w | |||
| CHEMBL168169 | 64942 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 370 | 9 | 0 | 6 | 4.3 | CCCN(CCC)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C)n1 | 10.1021/jm980222w | |||
| 44341680 | 117819 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 432 | 8 | 0 | 4 | 7.0 | CCCCN(c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12)C(CC)CC | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL326284 | 117819 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 432 | 8 | 0 | 4 | 7.0 | CCCCN(c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12)C(CC)CC | 10.1016/s0960-894x(03)00622-x | |||
| 44446731 | 101643 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 400 | 7 | 0 | 3 | 6.5 | COc1cc(C)cc(C)c1-c1nc(C)c(N(CC2CC2)CC2CC2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL253914 | 101643 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 400 | 7 | 0 | 3 | 6.5 | COc1cc(C)cc(C)c1-c1nc(C)c(N(CC2CC2)CC2CC2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 20780066 | 73677 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 508 | 6 | 0 | 4 | 7.0 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CC4CC4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL186479 | 73677 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 508 | 6 | 0 | 4 | 7.0 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CC4CC4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| 10503714 | 64212 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 449 | 8 | 0 | 8 | 3.4 | COCC(COC)Oc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL165478 | 64212 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 449 | 8 | 0 | 8 | 3.4 | COCC(COC)Oc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 10740327 | 65777 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 410 | 8 | 0 | 6 | 4.4 | COCCN(CCOC)c1nc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL169083 | 65777 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 410 | 8 | 0 | 6 | 4.4 | COCCN(CCOC)c1nc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| 10712065 | 65796 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 338 | 5 | 1 | 6 | 4.0 | CCCC(C)Nc1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL169280 | 65796 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 338 | 5 | 1 | 6 | 4.0 | CCCC(C)Nc1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL1077301 | 215270 | 0 | None | 12 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm990590f | |||||
| 53310132 | 70716 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 411 | 9 | 1 | 5 | 5.8 | CCc1nc(-c2ccc(OC(F)(F)F)cc2OC)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1806730 | 70716 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 411 | 9 | 1 | 5 | 5.8 | CCc1nc(-c2ccc(OC(F)(F)F)cc2OC)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 11751120 | 140402 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 406 | 6 | 0 | 4 | 6.2 | CCCC(CCC)N1CCc2cn(-c3ccc(C#N)cc3Cl)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL371407 | 140402 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 406 | 6 | 0 | 4 | 6.2 | CCCC(CCC)N1CCc2cn(-c3ccc(C#N)cc3Cl)c3nc(C)cc1c23 | 10.1021/jm050070m | |||
| CHEMBL429560 | 220319 | 0 | None | -2 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(N)=O | 10.1021/jm990590f | |||||
| 122193725 | 130743 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 476 | 7 | 0 | 4 | 5.6 | CCN(CC)c1cc(C)nc2c1N(CCF)C(=O)CN2c1ccc(C(C)C)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| CHEMBL3628744 | 130743 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 476 | 7 | 0 | 4 | 5.6 | CCN(CC)c1cc(C)nc2c1N(CCF)C(=O)CN2c1ccc(C(C)C)cc1Br | 10.1016/j.bmcl.2015.10.010 | |||
| 18449319 | 70715 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 357 | 9 | 1 | 5 | 4.9 | CCc1nc(-c2ccc(OC)cc2OC)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1806729 | 70715 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 357 | 9 | 1 | 5 | 4.9 | CCc1nc(-c2ccc(OC)cc2OC)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 11305354 | 130607 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 444 | 10 | 0 | 5 | 6.4 | CCCCC(c1ccc(F)cc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL362453 | 130607 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 444 | 10 | 0 | 5 | 6.4 | CCCCC(c1ccc(F)cc1)N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1 | 10.1021/jm049339c | |||
| 11450996 | 129033 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 351 | 6 | 0 | 5 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3cnc(C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL359784 | 129033 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 351 | 6 | 0 | 5 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3cnc(C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 9957619 | 65937 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 498 | 8 | 0 | 8 | 3.1 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(Br)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169955 | 65937 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 498 | 8 | 0 | 8 | 3.1 | COCCN(CCOC)c1nc(C)nc2c1nnn2-c1ccc(Br)cc1Br | 10.1021/jm980224g | |||
| 9910700 | 65819 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 432 | 7 | 1 | 7 | 4.2 | CCC(COC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169416 | 65819 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 432 | 7 | 1 | 7 | 4.2 | CCC(COC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 9932463 | 172475 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 430 | 7 | 0 | 6 | 5.0 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL424539 | 172475 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 430 | 7 | 0 | 6 | 5.0 | CCCCN(CC)c1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44387042 | 172895 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 459 | 7 | 0 | 6 | 4.9 | CCCN(CCC)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL426044 | 172895 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 459 | 7 | 0 | 6 | 4.9 | CCCN(CCC)c1nc(C)nc2c1n(C)c(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 10690278 | 65941 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 366 | 7 | 1 | 6 | 4.8 | CCCCC(CC)Nc1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| CHEMBL169979 | 65941 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 366 | 7 | 1 | 6 | 4.8 | CCCCC(CC)Nc1nc(C)nc2c1nnn2-c1c(C)cc(C)cc1C | 10.1021/jm980224g | |||
| 53310275 | 70750 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 355 | 8 | 1 | 5 | 4.6 | CCc1nc(-c2cnc(C)cc2N(C)C)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1806957 | 70750 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 355 | 8 | 1 | 5 | 4.6 | CCc1nc(-c2cnc(C)cc2N(C)C)c(CC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 44352447 | 125250 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 603 | 8 | 1 | 4 | 7.8 | CCCN(Cc1sc(Nc2c(Br)cc(Br)cc2Br)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL341313 | 125250 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 603 | 8 | 1 | 4 | 7.8 | CCCN(Cc1sc(Nc2c(Br)cc(Br)cc2Br)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 44266496 | 105291 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 459 | 5 | 0 | 3 | 7.6 | CCN(c1nc(C)cc(-c2cccc3ccccc23)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL276184 | 105291 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 459 | 5 | 0 | 3 | 7.6 | CCN(c1nc(C)cc(-c2cccc3ccccc23)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 22249028 | 70717 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 371 | 10 | 1 | 5 | 5.3 | CCOc1ccc(-c2nc(CC)c(NC(CC)CC)nc2CC)c(OC)c1 | 10.1021/jm200365y | |||
| CHEMBL1806731 | 70717 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 371 | 10 | 1 | 5 | 5.3 | CCOc1ccc(-c2nc(CC)c(NC(CC)CC)nc2CC)c(OC)c1 | 10.1021/jm200365y | |||
| 16730517 | 100351 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 451 | 7 | 0 | 5 | 6.0 | CCN(CCc1ccccc1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL246501 | 100351 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 451 | 7 | 0 | 5 | 6.0 | CCN(CCc1ccccc1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12 | 10.1016/j.bmcl.2007.01.008 | |||
| 3520 | 10041 | 54 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm050070m | |||
| 9821250 | 10041 | 54 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm050070m | |||
| CHEMBL309138 | 10041 | 54 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10.1021/jm050070m | |||
| 11710664 | 76449 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 380 | 4 | 0 | 4 | 5.4 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3C)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL193522 | 76449 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 380 | 4 | 0 | 4 | 5.4 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3C)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 11560105 | 78335 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 386 | 3 | 0 | 4 | 5.3 | Cc1cc2c3c(n1)c(-c1ccc(Cl)cc1Cl)nn3C[C@H](C)N2CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL196307 | 78335 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 386 | 3 | 0 | 4 | 5.3 | Cc1cc2c3c(n1)c(-c1ccc(Cl)cc1Cl)nn3C[C@H](C)N2CC1CC1 | 10.1021/jm049085v | |||
| 11525846 | 78599 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 442 | 5 | 0 | 4 | 6.6 | CC[C@H]1Cn2nc(-c3ccc(C(C)C)cc3C(F)(F)F)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL196879 | 78599 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 442 | 5 | 0 | 4 | 6.6 | CC[C@H]1Cn2nc(-c3ccc(C(C)C)cc3C(F)(F)F)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 11691278 | 139916 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 468 | 4 | 0 | 4 | 6.5 | CC[C@H]1Cn2nc(-c3ccc(C(F)(F)F)cc3C(F)(F)F)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL370346 | 139916 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 468 | 4 | 0 | 4 | 6.5 | CC[C@H]1Cn2nc(-c3ccc(C(F)(F)F)cc3C(F)(F)F)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 11524791 | 142004 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 430 | 5 | 0 | 5 | 5.4 | CC[C@H]1Cn2nc(-c3ccc(OC)cc3C(F)(F)F)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL372365 | 142004 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 430 | 5 | 0 | 5 | 5.4 | CC[C@H]1Cn2nc(-c3ccc(OC)cc3C(F)(F)F)c3nc(C)cc(c32)N1CC1CC1 | 10.1021/jm049085v | |||
| 44341809 | 16991 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 414 | 9 | 0 | 5 | 6.0 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(OC)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL116011 | 16991 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 414 | 9 | 0 | 5 | 6.0 | CCCCN(CCCC)c1cc(C)nc2c(-c3ccc(OC)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 10573028 | 38087 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 398 | 7 | 1 | 4 | 6.1 | CCCN(CC1CC1)c1cc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)n1 | 10.1021/jm960149e | |||
| CHEMBL140175 | 38087 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 398 | 7 | 1 | 4 | 6.1 | CCCN(CC1CC1)c1cc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)n1 | 10.1021/jm960149e | |||
| 44267068 | 175707 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 1428 | 40 | 17 | 18 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)C(CCCCC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N1)C(C)C)[C@@H](C)CC)C(N)=O | 10.1021/jm034180+ | |||
| CHEMBL438724 | 175707 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 1428 | 40 | 17 | 18 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)C(CCCCC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N1)C(C)C)[C@@H](C)CC)C(N)=O | 10.1021/jm034180+ | |||
| 44306535 | 169462 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 409 | 9 | 0 | 7 | 4.7 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C1(c2ccoc2)CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL417033 | 169462 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 409 | 9 | 0 | 7 | 4.7 | CCCN(c1nccc(-c2c(OC)cc(OC)cc2OC)n1)C1(c2ccoc2)CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| 20780050 | 100687 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 483 | 5 | 0 | 5 | 6.3 | Cc1cc(C)c(-n2c3ncccc3n3c(CN4CCC(Cc5ccccc5)C4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL248162 | 100687 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 483 | 5 | 0 | 5 | 6.3 | Cc1cc(C)c(-n2c3ncccc3n3c(CN4CCC(Cc5ccccc5)C4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| 20780052 | 100688 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 497 | 6 | 0 | 5 | 6.7 | Cc1cc(C)c(-n2c3ncccc3n3c(CN4CCC(CCc5ccccc5)C4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL248163 | 100688 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 497 | 6 | 0 | 5 | 6.7 | Cc1cc(C)c(-n2c3ncccc3n3c(CN4CCC(CCc5ccccc5)C4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| 20780120 | 73999 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 456 | 7 | 0 | 4 | 6.8 | CCCCN(CC)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL187923 | 73999 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 456 | 7 | 0 | 4 | 6.8 | CCCCN(CC)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 22249115 | 70767 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 371 | 6 | 1 | 3 | 6.3 | CCc1nc(NC(CC)CC)c(Cl)nc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| CHEMBL1807033 | 70767 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 371 | 6 | 1 | 3 | 6.3 | CCc1nc(NC(CC)CC)c(Cl)nc1-c1ccc(Cl)cc1Cl | 10.1021/jm200365y | |||
| 44443570 | 161552 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 342 | 9 | 0 | 5 | 4.7 | CCCN(CCC)c1nc(CC)c(Oc2cc(C)ccn2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL400154 | 161552 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 342 | 9 | 0 | 5 | 4.7 | CCCN(CCC)c1nc(CC)c(Oc2cc(C)ccn2)nc1CC | 10.1016/j.bmcl.2007.09.008 | |||
| 22324340 | 212845 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 355 | 7 | 0 | 4 | 4.8 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2C)n(CC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL85416 | 212845 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 355 | 7 | 0 | 4 | 4.8 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2C)n(CC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 44337493 | 116562 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 338 | 7 | 0 | 4 | 4.5 | CCCN(c1nc(-c2ccc(C)cc2C)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL323257 | 116562 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 338 | 7 | 0 | 4 | 4.5 | CCCN(c1nc(-c2ccc(C)cc2C)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| 22324337 | 171181 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 387 | 10 | 0 | 6 | 4.3 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2OC)n(CCC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL421334 | 171181 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 387 | 10 | 0 | 6 | 4.3 | CCCN(CCC)c1c(C)nc(-c2ccc(OC)cc2OC)n(CCC)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 10644018 | 64358 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 387 | 2 | 0 | 3 | 5.7 | Cc1cc(Cl)c2c(C#N)cn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| CHEMBL166732 | 64358 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 387 | 2 | 0 | 3 | 5.7 | Cc1cc(Cl)c2c(C#N)cn(-c3ccc(C(C)C)cc3Br)c2n1 | 10.1021/jm980223o | |||
| 44352454 | 123640 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 431 | 8 | 1 | 4 | 6.8 | CCCN(Cc1sc(Nc2c(C)cc(Cl)cc2C)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL338154 | 123640 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 431 | 8 | 1 | 4 | 6.8 | CCCN(Cc1sc(Nc2c(C)cc(Cl)cc2C)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 20780281 | 175032 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 448 | 7 | 0 | 4 | 5.3 | CCc1nc2n(c1C(=O)N(CCC(F)(F)F)CC1CC1)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL433768 | 175032 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 448 | 7 | 0 | 4 | 5.3 | CCc1nc2n(c1C(=O)N(CCC(F)(F)F)CC1CC1)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 10277887 | 71082 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 485 | 8 | 1 | 4 | 7.9 | CCCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CCC1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181075 | 71082 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 485 | 8 | 1 | 4 | 7.9 | CCCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CCC1 | 10.1016/j.bmcl.2004.10.055 | |||
| 44317964 | 110933 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 428 | 7 | 1 | 3 | 5.9 | O=C(CCc1ccncc1)C(Nc1ccccc1Cl)c1ccccc1Br | 10.1021/jm049974i | |||
| CHEMBL309546 | 110933 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 428 | 7 | 1 | 3 | 5.9 | O=C(CCc1ccncc1)C(Nc1ccccc1Cl)c1ccccc1Br | 10.1021/jm049974i | |||
| 20780269 | 137447 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 380 | 7 | 0 | 4 | 4.6 | C=CCN(CCC)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL368245 | 137447 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 380 | 7 | 0 | 4 | 4.6 | C=CCN(CCC)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 20780071 | 132583 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 558 | 7 | 0 | 4 | 7.8 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCc4ccccc4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL364809 | 132583 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 558 | 7 | 0 | 4 | 7.8 | Cc1cc(C)c(-n2c3ccccc3n3c(CN(CCc4ccccc4)CC(F)(F)F)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2005.06.028 | |||
| 20780139 | 74229 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 496 | 6 | 0 | 4 | 7.0 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)CC(F)(F)F | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL189115 | 74229 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 496 | 6 | 0 | 4 | 7.0 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)CC(F)(F)F | 10.1016/j.bmcl.2005.06.028 | |||
| 20780138 | 129136 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 546 | 7 | 0 | 4 | 7.6 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)CC(F)(F)C(F)(F)F | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL360000 | 129136 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 546 | 7 | 0 | 4 | 7.6 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)CC(F)(F)C(F)(F)F | 10.1016/j.bmcl.2005.06.028 | |||
| 20780278 | 72858 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 7 | 0 | 4 | 5.5 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(Cl)cc1Cl | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL183824 | 72858 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 7 | 0 | 4 | 5.5 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(Cl)cc1Cl | 10.1016/j.bmcl.2005.05.117 | |||
| 11375414 | 82364 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 497 | 7 | 1 | 6 | 6.3 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCc3cccc(C#N)c3)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL204657 | 82364 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 497 | 7 | 1 | 6 | 6.3 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCc3cccc(C#N)c3)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| 44317759 | 212359 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 390 | 8 | 1 | 3 | 6.0 | C=Cc1ccccc1C(Nc1ccc(C)cc1Cl)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| CHEMBL81376 | 212359 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 390 | 8 | 1 | 3 | 6.0 | C=Cc1ccccc1C(Nc1ccc(C)cc1Cl)C(=O)CCc1ccncc1 | 10.1021/jm049974i | |||
| 44587373 | 194769 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 385 | 10 | 0 | 5 | 5.4 | CCCc1nc(-c2c(C)cc(C)cc2OC)nc(OC)c1N(CCC)CCC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL497287 | 194769 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 385 | 10 | 0 | 5 | 5.4 | CCCc1nc(-c2c(C)cc(C)cc2OC)nc(OC)c1N(CCC)CCC | 10.1016/j.bmcl.2008.07.063 | |||
| 21916339 | 14054 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 422 | 3 | 0 | 4 | 5.5 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CC=CCC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1086015 | 14054 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 422 | 3 | 0 | 4 | 5.5 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CC=CCC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 46890890 | 13771 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 475 | 6 | 0 | 5 | 5.8 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(C)CCc4ccncc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1084722 | 13771 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 475 | 6 | 0 | 5 | 5.8 | Cc1cc(C)c(-n2c(Cl)cn3c(CN(C)CCc4ccncc4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 44307855 | 210441 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 357 | 6 | 0 | 5 | 4.6 | CCCN(CCC)c1nc(C)nc2c(-c3ccccc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| CHEMBL67360 | 210441 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 357 | 6 | 0 | 5 | 4.6 | CCCN(CCC)c1nc(C)nc2c(-c3ccccc3Cl)n(C)nc12 | 10.1016/s0960-894x(02)00358-x | |||
| 44305202 | 209635 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 356 | 6 | 0 | 4 | 5.3 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| CHEMBL62533 | 209635 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 356 | 6 | 0 | 4 | 5.3 | CCCCN(CC)c1cc(C)nc2c(-c3ccc(Cl)cc3)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| 20780250 | 70133 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 408 | 8 | 0 | 4 | 5.2 | CCCN(CCC1CC1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL179499 | 70133 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 408 | 8 | 0 | 4 | 5.2 | CCCN(CCC1CC1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 18672270 | 130106 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 497 | 8 | 1 | 5 | 7.9 | CCCN(Cc1ccco1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL361647 | 130106 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 497 | 8 | 1 | 5 | 7.9 | CCCN(Cc1ccco1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 20780117 | 74545 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 518 | 8 | 0 | 4 | 8.0 | CCCCN(Cc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL190823 | 74545 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 518 | 8 | 0 | 4 | 8.0 | CCCCN(Cc1ccccc1)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 44307783 | 210858 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 309 | 5 | 1 | 6 | 3.0 | COc1cccc(O/C(=N/Nc2ccccc2C#N)C(C)=O)c1 | 10.1021/jm025512y | |||
| CHEMBL70142 | 210858 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 309 | 5 | 1 | 6 | 3.0 | COc1cccc(O/C(=N/Nc2ccccc2C#N)C(C)=O)c1 | 10.1021/jm025512y | |||
| 44392723 | 130486 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.8 | COCCN(CCOC)c1cc(C)nc2c(-c3ncc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL362203 | 130486 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 423 | 8 | 0 | 7 | 3.8 | COCCN(CCOC)c1cc(C)nc2c(-c3ncc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 21916321 | 14094 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 440 | 7 | 0 | 4 | 6.3 | CCCCN(CC)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1086142 | 14094 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 440 | 7 | 0 | 4 | 6.3 | CCCCN(CC)Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12 | 10.1016/j.bmcl.2010.04.094 | |||
| 18691321 | 214893 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 452 | 6 | 0 | 4 | 6.6 | CCN(c1nc(C)cc(-c2ccccc2N(C)C)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL9794 | 214893 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 452 | 6 | 0 | 4 | 6.6 | CCN(c1nc(C)cc(-c2ccccc2N(C)C)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 44392801 | 129302 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 4.4 | CCCN(CC1CC1)c1cc(C(O)c2c(C)cc(C)cc2C)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL360128 | 129302 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 4.4 | CCCN(CC1CC1)c1cc(C(O)c2c(C)cc(C)cc2C)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| 10666432 | 127638 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 362 | 2 | 0 | 2 | 5.9 | Cc1cc(Cl)nc2c1ccn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980223o | |||
| CHEMBL355882 | 127638 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 362 | 2 | 0 | 2 | 5.9 | Cc1cc(Cl)nc2c1ccn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980223o | |||
| 12967652 | 71365 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.9 | CCN(CCc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL181662 | 71365 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.9 | CCN(CCc1ccccc1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F | 10.1016/j.bmcl.2004.10.055 | |||
| 11703243 | 130919 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 360 | 2 | 0 | 4 | 4.9 | Cc1cc2c3c(n1)c(-c1ccc(Cl)cc1Cl)nn3CCN2C(C)C | 10.1021/jm049085v | |||
| CHEMBL363394 | 130919 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 360 | 2 | 0 | 4 | 4.9 | Cc1cc2c3c(n1)c(-c1ccc(Cl)cc1Cl)nn3CCN2C(C)C | 10.1021/jm049085v | |||
| 11706059 | 131112 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 388 | 3 | 0 | 4 | 5.7 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1C(C)C | 10.1021/jm049085v | |||
| CHEMBL363616 | 131112 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 388 | 3 | 0 | 4 | 5.7 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1C(C)C | 10.1021/jm049085v | |||
| 11516283 | 140405 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 372 | 3 | 0 | 4 | 4.9 | Cc1cc2c3c(n1)c(-c1ccc(Cl)cc1Cl)nn3CCN2CC1CC1 | 10.1021/jm049085v | |||
| CHEMBL371453 | 140405 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 372 | 3 | 0 | 4 | 4.9 | Cc1cc2c3c(n1)c(-c1ccc(Cl)cc1Cl)nn3CCN2CC1CC1 | 10.1021/jm049085v | |||
| 11602680 | 78597 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 346 | 2 | 1 | 4 | 4.9 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1 | 10.1021/jm049085v | |||
| CHEMBL196873 | 78597 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 346 | 2 | 1 | 4 | 4.9 | CC[C@H]1Cn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc(c32)N1 | 10.1021/jm049085v | |||
| 11474047 | 132302 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 366 | 5 | 0 | 6 | 3.5 | CCC(CC)N1CCn2c(=O)n(-c3ccc(OC)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL364680 | 132302 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 366 | 5 | 0 | 6 | 3.5 | CCC(CC)N1CCn2c(=O)n(-c3ccc(OC)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 10622647 | 127578 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 432 | 9 | 0 | 5 | 5.5 | CCCCN(CC)c1cc(C)nc(N(CC)c2ccc(C(C)=O)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL355544 | 127578 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 432 | 9 | 0 | 5 | 5.5 | CCCCN(CC)c1cc(C)nc(N(CC)c2ccc(C(C)=O)cc2Br)n1 | 10.1021/jm980222w | |||
| 10548743 | 171762 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 395 | 10 | 0 | 7 | 4.2 | CCCCN(CCC#N)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C)n1 | 10.1021/jm980222w | |||
| CHEMBL422555 | 171762 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 395 | 10 | 0 | 7 | 4.2 | CCCCN(CCC#N)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C)n1 | 10.1021/jm980222w | |||
| 10571912 | 176231 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 381 | 9 | 0 | 7 | 3.8 | CCCCN(CC#N)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C)n1 | 10.1021/jm980222w | |||
| CHEMBL442773 | 176231 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 381 | 9 | 0 | 7 | 3.8 | CCCCN(CC#N)c1nc(C)nc(N(CC)c2ccc(N(C)C)cc2C)n1 | 10.1021/jm980222w | |||
| 44381468 | 127220 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 445 | 8 | 1 | 6 | 5.2 | CCC(CCOC)Nc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL353891 | 127220 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 445 | 8 | 1 | 6 | 5.2 | CCC(CCOC)Nc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 23068426 | 70778 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 367 | 7 | 1 | 4 | 5.6 | CCc1nc(-c2ccc(Cl)cc2Cl)c(OC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1807048 | 70778 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 367 | 7 | 1 | 4 | 5.6 | CCc1nc(-c2ccc(Cl)cc2Cl)c(OC)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 9891049 | 14273 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 474 | 6 | 0 | 4 | 6.1 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN(CC2CC2)CC(F)(F)F)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| CHEMBL1087165 | 14273 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 474 | 6 | 0 | 4 | 6.1 | Cc1cc(C)c(N2CCCn3c2nc(C(F)(F)F)c3CN(CC2CC2)CC(F)(F)F)c(C)c1 | 10.1016/j.bmcl.2010.01.127 | |||
| 44446726 | 101609 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 476 | 11 | 0 | 3 | 7.5 | CCCN(CCC)c1c(C)nc(-c2c(CC(F)F)cc(CC(F)F)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL253699 | 101609 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 476 | 11 | 0 | 3 | 7.5 | CCCN(CCC)c1c(C)nc(-c2c(CC(F)F)cc(CC(F)F)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 44587456 | 194827 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 344 | 7 | 0 | 5 | 4.7 | CCC(CC)Oc1c(C)nc(-c2c(C)cc(C)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL497652 | 194827 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 344 | 7 | 0 | 5 | 4.7 | CCC(CC)Oc1c(C)nc(-c2c(C)cc(C)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| 127033836 | 145405 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 3848 | 124 | 56 | 50 | -13.2 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| CHEMBL3775830 | 145405 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 3848 | 124 | 56 | 50 | -13.2 | CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)C(CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C)C(=O)N[C@H](C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b00926 | |||
| 44341814 | 117441 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 422 | 8 | 0 | 6 | 4.4 | COCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL325918 | 117441 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 422 | 8 | 0 | 6 | 4.4 | COCCN(CCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 21916322 | 159598 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 429 | 7 | 0 | 5 | 5.9 | CCCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12)CC1CCC1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL397389 | 159598 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 429 | 7 | 0 | 5 | 5.9 | CCCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12)CC1CCC1 | 10.1016/j.bmcl.2007.01.008 | |||
| 21916270 | 13166 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 480 | 6 | 0 | 4 | 6.5 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12)CC(F)(F)F | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1082302 | 13166 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 480 | 6 | 0 | 4 | 6.5 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12)CC(F)(F)F | 10.1016/j.bmcl.2010.04.094 | |||
| 44266431 | 11249 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 485 | 6 | 0 | 3 | 8.2 | CCN(c1nc(C)cc(-c2ccccc2-c2ccccc2)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL10189 | 11249 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 485 | 6 | 0 | 3 | 8.2 | CCN(c1nc(C)cc(-c2ccccc2-c2ccccc2)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 22249051 | 70776 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 369 | 7 | 1 | 5 | 5.1 | CCC(CC)Nc1nc(OC)c(-c2ccc(Cl)cc2Cl)nc1OC | 10.1021/jm200365y | |||
| CHEMBL1807042 | 70776 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 369 | 7 | 1 | 5 | 5.1 | CCC(CC)Nc1nc(OC)c(-c2ccc(Cl)cc2Cl)nc1OC | 10.1021/jm200365y | |||
| 20780048 | 155358 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 469 | 4 | 0 | 5 | 6.2 | Cc1cc(C)c(-n2c3ncccc3n3c(CN4CCC(c5ccccc5)C4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL393901 | 155358 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 469 | 4 | 0 | 5 | 6.2 | Cc1cc(C)c(-n2c3ncccc3n3c(CN4CCC(c5ccccc5)C4)c(C)nc23)c(Cl)c1 | 10.1016/j.bmcl.2007.01.008 | |||
| 9824147 | 169498 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 432 | 8 | 0 | 8 | 4.5 | COCCN(CCOC)c1nc(C)nc2c1sc(=S)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00159-6 | |||
| CHEMBL417091 | 169498 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 432 | 8 | 0 | 8 | 4.5 | COCCN(CCOC)c1nc(C)nc2c1sc(=S)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00159-6 | |||
| 9869432 | 25618 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 471 | 8 | 1 | 4 | 7.5 | CCCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL128100 | 25618 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 471 | 8 | 1 | 4 | 7.5 | CCCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2003.08.055 | |||
| 44347436 | 23148 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 450 | 7 | 0 | 5 | 5.4 | CCCN(CC1CC1)c1cc([S+](C)[O-])nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| CHEMBL122960 | 23148 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 450 | 7 | 0 | 5 | 5.4 | CCCN(CC1CC1)c1cc([S+](C)[O-])nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12 | 10.1016/j.bmcl.2004.05.019 | |||
| 15490817 | 105334 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 495 | 6 | 0 | 5 | 6.4 | CCN(c1nc(C)cc(-c2ccccc2C(F)(F)F)n1)c1c(Br)cc(OC)cc1OC | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL276599 | 105334 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 495 | 6 | 0 | 5 | 6.4 | CCN(c1nc(C)cc(-c2ccccc2C(F)(F)F)n1)c1c(Br)cc(OC)cc1OC | 10.1016/s0960-894x(99)00132-8 | |||
| 22249156 | 70773 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 5.9 | CCc1nc(-c2ccc(Cl)cc2Cl)c(C)nc1NC(CC)CC | 10.1021/jm200365y | |||
| CHEMBL1807039 | 70773 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 351 | 6 | 1 | 3 | 5.9 | CCc1nc(-c2ccc(Cl)cc2Cl)c(C)nc1NC(CC)CC | 10.1021/jm200365y | |||
| 9869432 | 25618 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 471 | 8 | 1 | 4 | 7.5 | CCCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL128100 | 25618 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 471 | 8 | 1 | 4 | 7.5 | CCCN(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)CC1CC1 | 10.1016/j.bmcl.2004.10.055 | |||
| 11235359 | 73062 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 414 | 6 | 0 | 6 | 5.3 | CCCN(c1ccccc1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL184752 | 73062 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 414 | 6 | 0 | 6 | 5.3 | CCCN(c1ccccc1)c1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 44341733 | 16689 | 1 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 352 | 6 | 0 | 2 | 6.5 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL114419 | 16689 | 1 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 352 | 6 | 0 | 2 | 6.5 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3)cccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 44341456 | 117462 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 496 | 9 | 0 | 5 | 7.1 | CCCCN(CCc1ccc(OC)cc1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL325996 | 117462 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 496 | 9 | 0 | 5 | 7.1 | CCCCN(CCc1ccc(OC)cc1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 11383809 | 12143 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 392 | 8 | 0 | 4 | 5.7 | CCCN(c1nc(-c2ccc(Cl)cc2Cl)n(CC)n1)C(C1CC1)C1CC1 | 10.1021/jm049339c | |||
| CHEMBL106972 | 12143 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 392 | 8 | 0 | 4 | 5.7 | CCCN(c1nc(-c2ccc(Cl)cc2Cl)n(CC)n1)C(C1CC1)C1CC1 | 10.1021/jm049339c | |||
| 11383809 | 12143 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 392 | 8 | 0 | 4 | 5.7 | CCCN(c1nc(-c2ccc(Cl)cc2Cl)n(CC)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL106972 | 12143 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 392 | 8 | 0 | 4 | 5.7 | CCCN(c1nc(-c2ccc(Cl)cc2Cl)n(CC)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| 9998456 | 34204 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 357 | 9 | 1 | 7 | 3.6 | CCCN(CC1CC1)c1nc(C)nc(Nc2ccc(OC)cc2OC)n1 | 10.1021/jm960148m | |||
| CHEMBL136828 | 34204 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 357 | 9 | 1 | 7 | 3.6 | CCCN(CC1CC1)c1nc(C)nc(Nc2ccc(OC)cc2OC)n1 | 10.1021/jm960148m | |||
| 44315525 | 110967 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 387 | 10 | 1 | 8 | 3.6 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(OC)cc(OC)cc2OC)n1 | 10.1021/jm9900117 | |||
| CHEMBL309789 | 110967 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 387 | 10 | 1 | 8 | 3.6 | CCCN(CC1CC1)c1nc(C)nc(Nc2c(OC)cc(OC)cc2OC)n1 | 10.1021/jm9900117 | |||
| CHEMBL413613 | 219857 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N1)[C@@H](C)CC)C(N)=O | 10.1021/jm034180+ | |||||
| 44341463 | 117196 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 356 | 6 | 0 | 4 | 5.2 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| CHEMBL324495 | 117196 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 356 | 6 | 0 | 4 | 5.2 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3)n(C)nc12 | 10.1016/s0960-894x(03)00621-8 | |||
| 44392734 | 72038 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 337 | 7 | 0 | 4 | 4.3 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2ccccc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL182803 | 72038 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 337 | 7 | 0 | 4 | 4.3 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2ccccc2C)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 44392787 | 138569 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 383 | 9 | 0 | 6 | 4.0 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2ccc(OC)cc2OC)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL369333 | 138569 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 383 | 9 | 0 | 6 | 4.0 | CCCN(CC1CC1)c1nc(C)nc(C(=O)c2ccc(OC)cc2OC)c1C | 10.1016/j.bmcl.2004.05.072 | |||
| 44443645 | 161538 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 9 | 2 | 7 | 4.2 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OCCO | 10.1016/j.bmcl.2007.09.008 | |||
| CHEMBL400082 | 161538 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 9 | 2 | 7 | 4.2 | CCc1nc(Oc2cc(C)ccn2)c(CC)nc1N[C@@H]1c2ccccc2C[C@@H]1OCCO | 10.1016/j.bmcl.2007.09.008 | |||
| 10295681 | 25639 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 419 | 7 | 1 | 4 | 6.4 | CCCN(CCC)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C | 10.1016/j.bmcl.2003.08.055 | |||
| CHEMBL128201 | 25639 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 419 | 7 | 1 | 4 | 6.4 | CCCN(CCC)C(=O)c1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C | 10.1016/j.bmcl.2003.08.055 | |||
| 10622505 | 65835 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 429 | 8 | 0 | 7 | 4.3 | CCCCN(CC)c1cc(C)nc2c1nnn2-c1ccc(C(C)C)cc1S(C)(=O)=O | 10.1021/jm980224g | |||
| CHEMBL169521 | 65835 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 429 | 8 | 0 | 7 | 4.3 | CCCCN(CC)c1cc(C)nc2c1nnn2-c1ccc(C(C)C)cc1S(C)(=O)=O | 10.1021/jm980224g | |||
| 11453549 | 77344 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 442 | 10 | 0 | 6 | 5.9 | CCCC(c1ccccc1)N(CCC)c1nc(-c2cc(OC)c(OC)cc2Cl)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL194877 | 77344 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 442 | 10 | 0 | 6 | 5.9 | CCCC(c1ccccc1)N(CCC)c1nc(-c2cc(OC)c(OC)cc2Cl)n(C)n1 | 10.1021/jm049339c | |||
| 44266513 | 10994 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 485 | 6 | 0 | 3 | 8.2 | CCN(c1nc(C)cc(-c2cccc(-c3ccccc3)c2)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL10032 | 10994 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 485 | 6 | 0 | 3 | 8.2 | CCN(c1nc(C)cc(-c2cccc(-c3ccccc3)c2)n1)c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00132-8 | |||
| 11291132 | 71991 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 352 | 6 | 1 | 6 | 3.9 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL182595 | 71991 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 352 | 6 | 1 | 6 | 3.9 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N)cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 11291132 | 71991 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 352 | 6 | 1 | 6 | 3.9 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL182595 | 71991 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 352 | 6 | 1 | 6 | 3.9 | CCCN(CCC)c1cc(C)nc2c(-c3ncc(N)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 44407873 | 105012 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 414 | 5 | 1 | 4 | 5.7 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)Cc2ccc(Cl)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| CHEMBL274388 | 105012 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 414 | 5 | 1 | 4 | 5.7 | Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)Cc2ccc(Cl)cc2)c(C)c1 | 10.1016/j.bmcl.2005.10.097 | |||
| 44306205 | 209834 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 395 | 10 | 0 | 5 | 5.1 | CCCN(c1ncc(CC)c(-c2ccc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| CHEMBL63585 | 209834 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 395 | 10 | 0 | 5 | 5.1 | CCCN(c1ncc(CC)c(-c2ccc(OC)cc2OC)n1)C(C1CC1)C1CC1 | 10.1016/j.bmcl.2004.02.053 | |||
| 10958953 | 210330 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 346 | 5 | 1 | 5 | 3.7 | CC(=O)/C(=N\Nc1ccccc1[N+](=O)[O-])N(C)c1cccc(Cl)c1 | 10.1021/jm025512y | |||
| CHEMBL66602 | 210330 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 346 | 5 | 1 | 5 | 3.7 | CC(=O)/C(=N\Nc1ccccc1[N+](=O)[O-])N(C)c1cccc(Cl)c1 | 10.1021/jm025512y | |||
| 44392724 | 129890 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 357 | 6 | 0 | 5 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cn3)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL361099 | 129890 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 357 | 6 | 0 | 5 | 4.7 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cn3)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 11348744 | 133955 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 352 | 5 | 0 | 6 | 3.1 | CCCCN1CCn2c(=O)n(-c3ccc(OC)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL365745 | 133955 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 352 | 5 | 0 | 6 | 3.1 | CCCCN1CCn2c(=O)n(-c3ccc(OC)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 44385524 | 172893 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 445 | 7 | 1 | 6 | 5.3 | CCCCN(CC)c1nc(C)nc2c1nc(O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| CHEMBL426026 | 172893 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 445 | 7 | 1 | 6 | 5.3 | CCCCN(CC)c1nc(C)nc2c1nc(O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00108-0 | |||
| 10717634 | 11264 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 6.5 | CCCN(CCC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL10203 | 11264 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 6.5 | CCCN(CCC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 10026532 | 104057 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 444 | 9 | 0 | 4 | 6.5 | CCCN(CC1CC1)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL268993 | 104057 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 444 | 9 | 0 | 4 | 6.5 | CCCN(CC1CC1)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 10576982 | 127230 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 488 | 6 | 0 | 4 | 5.2 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(I)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL353973 | 127230 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 488 | 6 | 0 | 4 | 5.2 | CCN(CC)c1cc(C)nc(N(CC)c2ccc(I)cc2Br)n1 | 10.1021/jm980222w | |||
| 44341714 | 16881 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 382 | 7 | 0 | 3 | 6.5 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3)c(OC)ccc12 | 10.1016/s0960-894x(03)00684-x | |||
| CHEMBL115566 | 16881 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 382 | 7 | 0 | 3 | 6.5 | CCCN(CCC)c1cc(C)nc2c(-c3ccc(Cl)cc3)c(OC)ccc12 | 10.1016/s0960-894x(03)00684-x | |||
| 10138067 | 13409 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 438 | 6 | 0 | 4 | 6.0 | CCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12)CC1CC1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1083319 | 13409 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 438 | 6 | 0 | 4 | 6.0 | CCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12)CC1CC1 | 10.1016/j.bmcl.2010.04.094 | |||
| 10717634 | 11264 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 6.5 | CCCN(CCC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL10203 | 11264 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 432 | 9 | 0 | 4 | 6.5 | CCCN(CCC)c1cc(C)nc(N(CC)c2ccc(C(C)C)cc2Br)n1 | 10.1016/s0960-894x(99)00132-8 | |||
| 44446729 | 101642 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 390 | 8 | 0 | 3 | 6.7 | CCCN(CCC)c1c(CC)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL253913 | 101642 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 390 | 8 | 0 | 3 | 6.7 | CCCN(CCC)c1c(CC)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 24971237 | 194828 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 380 | 8 | 0 | 6 | 4.7 | CCC(CC)Oc1c(C)nc(-c2c(OC)cc(Cl)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL497653 | 194828 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 380 | 8 | 0 | 6 | 4.7 | CCC(CC)Oc1c(C)nc(-c2c(OC)cc(Cl)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| 44587457 | 194945 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 396 | 9 | 0 | 6 | 5.0 | CCC(CC)Oc1c(C)nc(-c2c(OC)cc(C(F)F)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL498667 | 194945 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 396 | 9 | 0 | 6 | 5.0 | CCC(CC)Oc1c(C)nc(-c2c(OC)cc(C(F)F)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| 11338351 | 85106 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 392 | 9 | 0 | 5 | 5.6 | CCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL2094044 | 85106 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 392 | 9 | 0 | 5 | 5.6 | CCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| CHEMBL2109792 | 85106 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 392 | 9 | 0 | 5 | 5.6 | CCC[C@@H](c1ccccc1)N(CCC)c1nc(-c2ccc(OC)cc2C)n(C)n1 | 10.1021/jm049339c | |||
| 9886113 | 15995 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 378 | 7 | 0 | 4 | 5.2 | CCCN(c1nc(-c2ccc(Cl)cc2Cl)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| CHEMBL110609 | 15995 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 378 | 7 | 0 | 4 | 5.2 | CCCN(c1nc(-c2ccc(Cl)cc2Cl)n(C)n1)C(C1CC1)C1CC1 | 10.1016/s0960-894x(01)00657-6 | |||
| 11773483 | 72347 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 382 | 7 | 0 | 7 | 4.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc([N+](=O)[O-])cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| CHEMBL183148 | 72347 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 382 | 7 | 0 | 7 | 4.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc([N+](=O)[O-])cc3C)c(C)nn12 | 10.1016/j.bmcl.2004.05.056 | |||
| 20780255 | 14161 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 452 | 7 | 0 | 4 | 6.3 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12)CC1CC1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1086468 | 14161 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 452 | 7 | 0 | 4 | 6.3 | CCCN(Cc1c(C(F)(F)F)nc2n(-c3c(C)cc(C)cc3C)c(Cl)cn12)CC1CC1 | 10.1016/j.bmcl.2010.04.094 | |||
| 15490818 | 11714 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 461 | 6 | 0 | 5 | 6.0 | CCN(c1nc(C)cc(-c2ccccc2Cl)n1)c1c(Br)cc(OC)cc1OC | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL10473 | 11714 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 461 | 6 | 0 | 5 | 6.0 | CCN(c1nc(C)cc(-c2ccccc2Cl)n1)c1c(Br)cc(OC)cc1OC | 10.1016/s0960-894x(99)00132-8 | |||
| 11773483 | 72347 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 382 | 7 | 0 | 7 | 4.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc([N+](=O)[O-])cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL183148 | 72347 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 382 | 7 | 0 | 7 | 4.3 | CCCN(CCC)c1cc(C)nc2c(-c3ncc([N+](=O)[O-])cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 9929418 | 168547 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 372 | 4 | 0 | 6 | 5.3 | CCN(CC)c1nc(C)nc2c1sc(=S)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00159-6 | |||
| CHEMBL413968 | 168547 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 372 | 4 | 0 | 6 | 5.3 | CCN(CC)c1nc(C)nc2c1sc(=S)n2-c1c(C)cc(C)cc1C | 10.1016/s0960-894x(99)00159-6 | |||
| 10836468 | 127043 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 431 | 7 | 0 | 6 | 4.5 | CCN(CCOC)c1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL352438 | 127043 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 431 | 7 | 0 | 6 | 4.5 | CCN(CCOC)c1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 9886113 | 15995 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 378 | 7 | 0 | 4 | 5.2 | CCCN(c1nc(-c2ccc(Cl)cc2Cl)n(C)n1)C(C1CC1)C1CC1 | 10.1021/jm049339c | |||
| CHEMBL110609 | 15995 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 378 | 7 | 0 | 4 | 5.2 | CCCN(c1nc(-c2ccc(Cl)cc2Cl)n(C)n1)C(C1CC1)C1CC1 | 10.1021/jm049339c | |||
| 9803011 | 105628 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 434 | 5 | 0 | 6 | 4.9 | CCN(CC)c1nc(C)nc2c1sc(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00159-6 | |||
| CHEMBL278895 | 105628 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 434 | 5 | 0 | 6 | 4.9 | CCN(CC)c1nc(C)nc2c1sc(=O)n2-c1ccc(C(C)C)cc1Br | 10.1016/s0960-894x(99)00159-6 | |||
| 9910700 | 65819 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 432 | 7 | 1 | 7 | 4.2 | CCC(COC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169416 | 65819 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 432 | 7 | 1 | 7 | 4.2 | CCC(COC)Nc1nc(C)nc2c1nnn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 9803011 | 105628 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 434 | 5 | 0 | 6 | 4.9 | CCN(CC)c1nc(C)nc2c1sc(=O)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm990590f | |||
| CHEMBL278895 | 105628 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 434 | 5 | 0 | 6 | 4.9 | CCN(CC)c1nc(C)nc2c1sc(=O)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm990590f | |||
| 18691325 | 10963 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 508 | 6 | 0 | 5 | 6.5 | CCN(c1nc(C)cc(-c2ccccc2C(F)(F)F)n1)c1c(Br)cc(N(C)C)cc1OC | 10.1016/s0960-894x(99)00132-8 | |||
| CHEMBL10015 | 10963 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 508 | 6 | 0 | 5 | 6.5 | CCN(c1nc(C)cc(-c2ccccc2C(F)(F)F)n1)c1c(Br)cc(N(C)C)cc1OC | 10.1016/s0960-894x(99)00132-8 | |||
| 11326060 | 73791 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 4.4 | CCC(CC)Nc1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| CHEMBL186992 | 73791 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 4.4 | CCC(CC)Nc1cc(C)nc2c(-c3cnc(N(C)C)cc3C)c(C)nn12 | 10.1021/jm040058e | |||
| 10646423 | 66135 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 432 | 7 | 0 | 6 | 4.8 | CCC(COC)Oc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL170788 | 66135 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 432 | 7 | 0 | 6 | 4.8 | CCC(COC)Oc1nc(C)nc2c1ncn2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44341805 | 117295 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 406 | 6 | 0 | 5 | 5.1 | COCCN(c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12)C(C)C | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL325051 | 117295 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 406 | 6 | 0 | 5 | 5.1 | COCCN(c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12)C(C)C | 10.1016/s0960-894x(03)00622-x | |||
| 10528542 | 65863 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 474 | 9 | 0 | 6 | 5.0 | COCCN(CCOC)c1cc(C)nc2c1nc(C)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| CHEMBL169641 | 65863 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 474 | 9 | 0 | 6 | 5.0 | COCCN(CCOC)c1cc(C)nc2c1nc(C)n2-c1ccc(C(C)C)cc1Br | 10.1021/jm980224g | |||
| 44341835 | 16267 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 420 | 8 | 0 | 5 | 5.5 | CCCN(CCCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| CHEMBL112045 | 16267 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 420 | 8 | 0 | 5 | 5.5 | CCCN(CCCOC)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)nn(C)c12 | 10.1016/s0960-894x(03)00622-x | |||
| 9822241 | 70783 | 8 | None | -9 | 2 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 399 | 8 | 1 | 6 | 5.0 | CCC(CC)Nc1nc(C)c(-c2ccc(OC(F)(F)F)cc2OC)nc1OC | 10.1021/jm200365y | |||
| CHEMBL1807053 | 70783 | 8 | None | -9 | 2 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 399 | 8 | 1 | 6 | 5.0 | CCC(CC)Nc1nc(C)c(-c2ccc(OC(F)(F)F)cc2OC)nc1OC | 10.1021/jm200365y | |||
| 11546255 | 194896 | 0 | None | 12022 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 419 | 5 | 0 | 7 | 4.9 | CCC(CC)c1cc(C)nn2c(-c3sc(N4CCOCC4)nc3Cl)c(C)nc12 | 10.1016/j.ejmech.2021.113867 | |||
| CHEMBL498311 | 194896 | 0 | None | 12022 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 419 | 5 | 0 | 7 | 4.9 | CCC(CC)c1cc(C)nn2c(-c3sc(N4CCOCC4)nc3Cl)c(C)nc12 | 10.1016/j.ejmech.2021.113867 | |||
| 9950645 | 112020 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 357 | 7 | 0 | 5 | 4.0 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)n(C)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL311520 | 112020 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 357 | 7 | 0 | 5 | 4.0 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)n(C)c1=O | 10.1016/s0960-894x(03)00483-9 | |||
| 10686834 | 127237 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 315 | 5 | 0 | 5 | 4.2 | CCN(c1nc(C)cc(C)n1)c1ccc(C(C)=O)cc1SC | 10.1021/jm980222w | |||
| CHEMBL354022 | 127237 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 315 | 5 | 0 | 5 | 4.2 | CCN(c1nc(C)cc(C)n1)c1ccc(C(C)=O)cc1SC | 10.1021/jm980222w | |||
| 44392742 | 130351 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 409 | 11 | 0 | 4 | 5.8 | CCCN(CC1CC1)c1cc(C(OC)c2c(CC)cc(CC)cc2CC)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| CHEMBL361831 | 130351 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 409 | 11 | 0 | 4 | 5.8 | CCCN(CC1CC1)c1cc(C(OC)c2c(CC)cc(CC)cc2CC)nc(C)n1 | 10.1016/j.bmcl.2004.05.072 | |||
| 11440355 | 69783 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 378 | 8 | 0 | 5 | 5.0 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)C(C(C)C)C(C)C | 10.1021/jm049339c | |||
| CHEMBL178702 | 69783 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 378 | 8 | 0 | 5 | 5.0 | CCCN(c1nc(-c2ccc(Cl)cc2OC)n(C)n1)C(C(C)C)C(C)C | 10.1021/jm049339c | |||
| 11304752 | 74429 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 422 | 7 | 0 | 7 | 4.1 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(C(=O)OC)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| CHEMBL190661 | 74429 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 422 | 7 | 0 | 7 | 4.1 | CCCC(CCC)N1CCn2c(=O)n(-c3ccc(C(=O)OC)cc3)c3nc(C)cc1c32 | 10.1021/jm050384+ | |||
| 21916077 | 14056 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 442 | 3 | 0 | 5 | 5.3 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCSCC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| CHEMBL1086017 | 14056 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 442 | 3 | 0 | 5 | 5.3 | Cc1cc(C)c(-n2c(Cl)cn3c(CN4CCSCC4)c(C(F)(F)F)nc23)c(C)c1 | 10.1016/j.bmcl.2010.04.094 | |||
| 44317760 | 212334 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 5.7 | Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2C)c(Cl)c1 | 10.1021/jm049974i | |||
| CHEMBL81117 | 212334 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 5.7 | Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2C)c(Cl)c1 | 10.1021/jm049974i | |||
| 44305209 | 210210 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 424 | 6 | 0 | 4 | 6.6 | CCCCN(CC)c1cc(C)nc2c(-c3c(Cl)cc(Cl)cc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| CHEMBL65724 | 210210 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 424 | 6 | 0 | 4 | 6.6 | CCCCN(CC)c1cc(C)nc2c(-c3c(Cl)cc(Cl)cc3Cl)c(C)nn12 | 10.1016/s0960-894x(98)00372-2 | |||
| 20780175 | 173382 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 401 | 6 | 0 | 5 | 5.1 | CCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12)CC1CC1 | 10.1016/j.bmcl.2007.01.008 | |||
| CHEMBL428048 | 173382 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 401 | 6 | 0 | 5 | 5.1 | CCN(Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12)CC1CC1 | 10.1016/j.bmcl.2007.01.008 | |||
| 135553002 | 212469 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 343 | 7 | 1 | 5 | 4.4 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)nc1O | 10.1016/s0960-894x(03)00483-9 | |||
| CHEMBL82265 | 212469 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 343 | 7 | 1 | 5 | 4.4 | CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)nc1O | 10.1016/s0960-894x(03)00483-9 | |||
| 44397631 | 73920 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 460 | 7 | 0 | 4 | 6.2 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n(-c3c(C)cc(C)cc3C)c3ccc(F)cc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| CHEMBL187577 | 73920 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 460 | 7 | 0 | 4 | 6.2 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n(-c3c(C)cc(C)cc3C)c3ccc(F)cc3n12 | 10.1016/j.bmcl.2005.06.028 | |||
| 11689443 | 71141 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 380 | 6 | 0 | 4 | 4.4 | CCc1nc2n(c1C(=O)N(CC)CC1CC1)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL181283 | 71141 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 380 | 6 | 0 | 4 | 4.4 | CCc1nc2n(c1C(=O)N(CC)CC1CC1)CCN2c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2005.05.117 | |||
| 20780028 | 138150 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 414 | 7 | 0 | 4 | 5.1 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1Cl | 10.1016/j.bmcl.2005.05.117 | |||
| CHEMBL368879 | 138150 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 414 | 7 | 0 | 4 | 5.1 | CCCN(CC1CC1)C(=O)c1c(CC)nc2n1CCN2c1c(C)cc(C)cc1Cl | 10.1016/j.bmcl.2005.05.117 | |||
| 44587377 | 179706 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 343 | 7 | 1 | 5 | 4.7 | CCC(CC)Nc1c(C)nc(-c2c(C)cc(C)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| CHEMBL451660 | 179706 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 343 | 7 | 1 | 5 | 4.7 | CCC(CC)Nc1c(C)nc(-c2c(C)cc(C)cc2OC)nc1OC | 10.1016/j.bmcl.2008.07.063 | |||
| 10616689 | 65511 | 1 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 333 | 3 | 0 | 3 | 4.7 | Cc1cc(C)nc(N(C)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980223o | |||
| CHEMBL168568 | 65511 | 1 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 333 | 3 | 0 | 3 | 4.7 | Cc1cc(C)nc(N(C)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980223o | |||
| 10616689 | 65511 | 1 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 333 | 3 | 0 | 3 | 4.7 | Cc1cc(C)nc(N(C)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| CHEMBL168568 | 65511 | 1 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 333 | 3 | 0 | 3 | 4.7 | Cc1cc(C)nc(N(C)c2ccc(C(C)C)cc2Br)n1 | 10.1021/jm980222w | |||
| 44446719 | 101553 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 352 | 6 | 0 | 2 | 6.5 | CCCN(CCC)c1c(C)nc(-c2ccc(Cl)cc2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| CHEMBL253286 | 101553 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 352 | 6 | 0 | 2 | 6.5 | CCCN(CCC)c1c(C)nc(-c2ccc(Cl)cc2)c2ccccc12 | 10.1016/j.bmcl.2007.12.050 | |||
| 44389088 | 69748 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 459 | 6 | 1 | 4 | 7.5 | CC(C)N(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)C(C)C | 10.1016/j.bmcl.2004.10.055 | |||
| CHEMBL178523 | 69748 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 459 | 6 | 1 | 4 | 7.5 | CC(C)N(Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F)C(C)C | 10.1016/j.bmcl.2004.10.055 | |||
| 10379 | 9833 | 39 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 28174066 | |||
| 9884366 | 9833 | 39 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 28174066 | |||
| CHEMBL482950 | 9833 | 39 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 28174066 | |||
| DB12572 | 9833 | 39 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | Guide to Pharmacology | 340 | 5 | 1 | 7 | 3.3 | CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C | 28174066 | |||
| 10377 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Guide to Pharmacology | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 18260619 | |||
| 9818802 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Guide to Pharmacology | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 18260619 | |||
| CHEMBL270738 | 7962 | 27 | None | 1 | 2 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Guide to Pharmacology | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 18260619 | |||
| 912 | 7950 | 0 | None | 1 | 4 | Human | 8.1 | pKd | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 11123370 | |||||
| 912 | 7950 | 0 | None | 1 | 4 | Human | 8.1 | pKd | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 7477349 | |||||
| 912 | 7950 | 0 | None | 1 | 4 | Human | 8.1 | pKd | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 7692441 | |||||
| 912 | 7950 | 0 | None | 1 | 4 | Human | 8.1 | pKd | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 8612563 | |||||
| 912 | 7950 | 0 | None | 1 | 4 | Human | 8.1 | pKd | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 9326293 | |||||
| 912 | 7950 | 0 | None | 1 | 4 | Human | 8.1 | pKd | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 9851694 | |||||
| 913 | 7951 | 0 | None | 44 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 11123370 | |||||
| 913 | 7951 | 0 | None | 44 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 15450949 | |||||
| 913 | 7951 | 0 | None | 44 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 9326293 | |||||
| 913 | 7951 | 0 | None | 44 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 9851694 | |||||
| 16133798 | 7294 | 0 | None | -3 | 4 | Human | 8.3 | pKd | = | 8.3 | Binding | Guide to Pharmacology | None | None | None | None | 11123370 | |||||
| 16133798 | 7294 | 0 | None | -3 | 4 | Human | 8.3 | pKd | = | 8.3 | Binding | Guide to Pharmacology | None | None | None | None | 9851694 | |||||
| 16133798 | 7294 | 0 | None | -3 | 4 | Human | 8.3 | pKd | = | 8.3 | Binding | Guide to Pharmacology | None | None | None | None | 9918582 | |||||
| 925 | 7294 | 0 | None | -3 | 4 | Human | 8.3 | pKd | = | 8.3 | Binding | Guide to Pharmacology | None | None | None | None | 11123370 | |||||
| 925 | 7294 | 0 | None | -3 | 4 | Human | 8.3 | pKd | = | 8.3 | Binding | Guide to Pharmacology | None | None | None | None | 9851694 | |||||
| 925 | 7294 | 0 | None | -3 | 4 | Human | 8.3 | pKd | = | 8.3 | Binding | Guide to Pharmacology | None | None | None | None | 9918582 | |||||
| 920 | 10721 | 0 | None | -1 | 3 | Human | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 11123370 | |||||
| 920 | 10721 | 0 | None | -1 | 3 | Human | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 11416224 | |||||
| 920 | 10721 | 0 | None | -1 | 3 | Human | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 7477349 | |||||
| 920 | 10721 | 0 | None | -1 | 3 | Human | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8612563 | |||||
| 920 | 10721 | 0 | None | -1 | 3 | Human | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 9918582 | |||||
| 919 | 10722 | 0 | None | -1 | 4 | Human | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 11123370 | |||||
| 919 | 10722 | 0 | None | -1 | 4 | Human | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 15450949 | |||||
| 919 | 10722 | 0 | None | -1 | 4 | Human | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8612563 | |||||
| 921 | 10724 | 0 | None | -8912 | 4 | Human | 5.4 | pKd | None | 5.4 | Binding | Guide to Pharmacology | None | None | None | None | 15450949 | |||||
| CHEMBL429970 | 10724 | 0 | None | -8912 | 4 | Human | 5.4 | pKd | None | 5.4 | Binding | Guide to Pharmacology | None | None | None | None | 15450949 | |||||
| 155817385 | 7148 | 0 | None | -31 | 3 | Human | 7.6 | pKd | None | 7.6 | Binding | Guide to Pharmacology | None | None | None | None | 9918582 | |||||
| 923 | 7148 | 0 | None | -31 | 3 | Human | 7.6 | pKd | None | 7.6 | Binding | Guide to Pharmacology | None | None | None | None | 9918582 | |||||
| 918 | 10261 | 0 | None | -3 | 4 | Human | 8.0 | pKd | None | 8.0 | Binding | Guide to Pharmacology | None | None | None | None | 11123370 | |||||
| 918 | 10261 | 0 | None | -3 | 4 | Human | 8.0 | pKd | None | 8.0 | Binding | Guide to Pharmacology | None | None | None | None | 15450949 | |||||
| 918 | 10261 | 0 | None | -3 | 4 | Human | 8.0 | pKd | None | 8.0 | Binding | Guide to Pharmacology | None | None | None | None | 7477349 | |||||
| 918 | 10261 | 0 | None | -3 | 4 | Human | 8.0 | pKd | None | 8.0 | Binding | Guide to Pharmacology | None | None | None | None | 8612563 | |||||
| 918 | 10261 | 0 | None | -3 | 4 | Human | 8.0 | pKd | None | 8.0 | Binding | Guide to Pharmacology | None | None | None | None | 9326293 | |||||
| 918 | 10261 | 0 | None | -3 | 4 | Human | 8.0 | pKd | None | 8.0 | Binding | Guide to Pharmacology | None | None | None | None | 9918582 | |||||
| 922 | 10729 | 0 | None | 1 | 3 | Human | 8.6 | pKd | None | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 11123370 | |||||
| 922 | 10729 | 0 | None | 1 | 3 | Human | 8.6 | pKd | None | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 7477349 | |||||
| 177990 | 7214 | 23 | 125I-Sauvagine | -1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | None | |||
| 3489 | 7214 | 23 | 125I-Sauvagine | -1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | None | |||
| CHEMBL296641 | 7214 | 23 | 125I-Sauvagine | -1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | None | |||
| 177990 | 7214 | 23 | 3H-NBI 35965 + GTP GammaS | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | None | |||
| 3489 | 7214 | 23 | 3H-NBI 35965 + GTP GammaS | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | None | |||
| CHEMBL296641 | 7214 | 23 | 3H-NBI 35965 + GTP GammaS | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | None | |||
| 177990 | 7214 | 23 | 125I-Sauvigine + GTP GammaS | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | None | |||
| 3489 | 7214 | 23 | 125I-Sauvigine + GTP GammaS | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | None | |||
| CHEMBL296641 | 7214 | 23 | 125I-Sauvigine + GTP GammaS | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | None | |||
| 177990 | 7214 | 23 | 125I-Sauvagine | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | None | |||
| 3489 | 7214 | 23 | 125I-Sauvagine | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | None | |||
| CHEMBL296641 | 7214 | 23 | 125I-Sauvagine | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | None | |||
| 177990 | 7214 | 23 | 125I-Astressin + GTP GammaS | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | None | |||
| 3489 | 7214 | 23 | 125I-Astressin + GTP GammaS | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | None | |||
| CHEMBL296641 | 7214 | 23 | 125I-Astressin + GTP GammaS | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | None | |||
| 10377 | 7962 | 27 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 18260619 | |||
| 9818802 | 7962 | 27 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 18260619 | |||
| CHEMBL270738 | 7962 | 27 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 327 | 6 | 0 | 3 | 6.0 | CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC | 18260619 | |||
| 10378 | 10757 | 37 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 406 | 6 | 1 | 8 | 4.6 | COc1ccc(c(c1)C)c1c(C)nn2c1nc(C)cc2N[C@H](c1onc(n1)C)CC | 21074436 | |||
| 11596613 | 10757 | 37 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 406 | 6 | 1 | 8 | 4.6 | COc1ccc(c(c1)C)c1c(C)nn2c1nc(C)cc2N[C@H](c1onc(n1)C)CC | 21074436 | |||
| CHEMBL1287935 | 10757 | 37 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 406 | 6 | 1 | 8 | 4.6 | COc1ccc(c(c1)C)c1c(C)nn2c1nc(C)cc2N[C@H](c1onc(n1)C)CC | 21074436 | |||
| DB12512 | 10757 | 37 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 406 | 6 | 1 | 8 | 4.6 | COc1ccc(c(c1)C)c1c(C)nn2c1nc(C)cc2N[C@H](c1onc(n1)C)CC | 21074436 | |||
| 10375 | 9516 | 18 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 416 | 6 | 0 | 4 | 6.5 | CCCC(N1CCn2c3c1cc(C)nc3c(n2)c1ccc(cc1Cl)Cl)CCC | 16078829 | |||
| 9888194 | 9516 | 18 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 416 | 6 | 0 | 4 | 6.5 | CCCC(N1CCn2c3c1cc(C)nc3c(n2)c1ccc(cc1Cl)Cl)CCC | 16078829 | |||
| CHEMBL188907 | 9516 | 18 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 416 | 6 | 0 | 4 | 6.5 | CCCC(N1CCn2c3c1cc(C)nc3c(n2)c1ccc(cc1Cl)Cl)CCC | 16078829 | |||
| 11025 | 9517 | 7 | None | -1 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 400 | 4 | 0 | 4 | 5.7 | CC[C@H]1Cn2nc(c3c2c(N1CC1CC1)cc(n3)C)c1ccc(cc1Cl)Cl | 12957366 | |||
| 11713007 | 9517 | 7 | None | -1 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 400 | 4 | 0 | 4 | 5.7 | CC[C@H]1Cn2nc(c3c2c(N1CC1CC1)cc(n3)C)c1ccc(cc1Cl)Cl | 12957366 | |||
| CHEMBL380800 | 9517 | 7 | None | -1 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 400 | 4 | 0 | 4 | 5.7 | CC[C@H]1Cn2nc(c3c2c(N1CC1CC1)cc(n3)C)c1ccc(cc1Cl)Cl | 12957366 | |||
| 177990 | 7214 | 23 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 8940412 | |||
| 3489 | 7214 | 23 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 8940412 | |||
| CHEMBL296641 | 7214 | 23 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 378 | 6 | 0 | 4 | 5.9 | CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC | 8940412 | |||
| 3499 | 8230 | 28 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10669572 | |||
| 9909468 | 8230 | 28 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10669572 | |||
| CHEMBL44698 | 8230 | 28 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 409 | 7 | 1 | 7 | 3.8 | COCC(Nc1nc(C)nc2n1nc(c2c1ccc(cc1Cl)Cl)C)COC | 10669572 | |||
| 176157 | 9515 | 28 | None | 9 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 8893829 | |||
| 3512 | 9515 | 28 | None | 9 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 8893829 | |||
| CHEMBL45281 | 9515 | 28 | None | 9 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 432 | 7 | 1 | 4 | 6.8 | CCCN(c1nc(C)nc(c1Cl)Nc1c(Cl)cc(cc1Cl)Cl)CC1CC1 | 8893829 | |||
| 3520 | 10041 | 54 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10867111 | |||
| 9821250 | 10041 | 54 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10867111 | |||
| CHEMBL309138 | 10041 | 54 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 380 | 7 | 0 | 6 | 4.4 | CCCN(c1cc(C)nc2n1nc(c2c1cnc(cc1C)N(C)C)C)CCC | 10867111 | |||
| 16133798 | 7294 | 0 | None | -3 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 24269930 | |||||
| 925 | 7294 | 0 | None | -3 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 24269930 | |||||
| 3533 | 7989 | 24 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 482 | 8 | 0 | 4 | 7.5 | C#CCN([C@H](c1ccc(c(c1)F)C)CC1CC1)c1sc(c(n1)c1cc(C)c(cc1Cl)OC)C | 11907190 | |||
| 5282340 | 7989 | 24 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 482 | 8 | 0 | 4 | 7.5 | C#CCN([C@H](c1ccc(c(c1)F)C)CC1CC1)c1sc(c(n1)c1cc(C)c(cc1Cl)OC)C | 11907190 | |||
| CHEMBL291657 | 7989 | 24 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 482 | 8 | 0 | 4 | 7.5 | C#CCN([C@H](c1ccc(c(c1)F)C)CC1CC1)c1sc(c(n1)c1cc(C)c(cc1Cl)OC)C | 11907190 | |||