Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
16158474 217727 17 None - 1 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP levelAgonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP level
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
CHEMBL3039582 217727 17 None - 1 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP levelAgonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP level
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
CHEMBL1256314 215444 0 None - 1 Human 10.0 pEC50 = 10 Functional
Agonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP levelAgonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP level
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N1)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
16158474 217727 17 None - 1 Human 8.0 pEC50 = 8.0 Functional
NoneNone
Drug Central None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C None
CHEMBL3039582 217727 17 None - 1 Human 8.0 pEC50 = 8.0 Functional
NoneNone
Drug Central None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C None
1155 10345 0 None 5 7 Human 9.7 pEC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7612008
16129665 10345 0 None 5 7 Human 9.7 pEC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7612008
3643 10345 0 None 5 7 Human 9.7 pEC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7612008
CHEMBL1201488 10345 0 None 5 7 Human 9.7 pEC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7612008
DB00021 10345 0 None 5 7 Human 9.7 pEC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7612008
1152 10767 16 None -3090 8 Human 5.4 pIC50 = 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
16129679 10767 16 None -3090 8 Human 5.4 pIC50 = 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
53395115 10767 16 None -3090 8 Human 5.4 pIC50 = 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
91898389 10767 16 None -3090 8 Human 5.4 pIC50 = 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
CHEMBL1981592 10767 16 None -3090 8 Human 5.4 pIC50 = 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
1156 10348 0 None - 1 Rat 5.0 pIC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Similar-
ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
CHEMBL1256314 215444 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysisDisplacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysis
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N1)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
16158474 217727 17 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysisDisplacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysis
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
CHEMBL3039582 217727 17 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysisDisplacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysis
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
1152 10767 16 None - 4 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
16129679 10767 16 None - 4 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
53395115 10767 16 None - 4 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
91898389 10767 16 None - 4 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
CHEMBL1981592 10767 16 None - 4 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
3293 7256 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
1155 10345 0 None 3162 2 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
16129665 10345 0 None 3162 2 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
3643 10345 0 None 3162 2 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
CHEMBL1201488 10345 0 None 3162 2 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
DB00021 10345 0 None 3162 2 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
3755 7711 0 None - 1 Human 5.3 pKi = 5.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702423
1155 10345 0 None 3162 2 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
16129665 10345 0 None 3162 2 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
3643 10345 0 None 3162 2 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
CHEMBL1201488 10345 0 None 3162 2 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
DB00021 10345 0 None 3162 2 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
2943 10346 0 None - 1 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10383421
2943 10346 0 None - 1 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9694908