Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
164609465 183897 0 None -1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells by luciferase reporter gene assayAgonist activity at frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells by luciferase reporter gene assay
ChEMBL 1425 27 21 24 -9.2 CSCC[C@@H]1NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)O)NC1=O nan
CHEMBL4847020 183897 0 None -1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells by luciferase reporter gene assayAgonist activity at frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells by luciferase reporter gene assay
ChEMBL 1425 27 21 24 -9.2 CSCC[C@@H]1NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)O)NC1=O nan
164610002 184065 0 None -5 4 Human 10.0 pIC50 = 10 Functional
Antagonist activity at Wnt3a-stimulated frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay
ChEMBL 1427 49 23 24 -9.7 CSCC[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O nan
CHEMBL4849630 184065 0 None -5 4 Human 10.0 pIC50 = 10 Functional
Antagonist activity at Wnt3a-stimulated frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay
ChEMBL 1427 49 23 24 -9.7 CSCC[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O nan
10197 3909 0 None -1 5 Human 9.0 pIC50 ~ 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 22753465


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
164610002 184065 0 None - 0 Rat 10.8 pIC50 = 10.8 Binding
Antagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay
ChEMBL 1427 49 23 24 -9.7 CSCC[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O nan
CHEMBL4849630 184065 0 None - 0 Rat 10.8 pIC50 = 10.8 Binding
Antagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay
ChEMBL 1427 49 23 24 -9.7 CSCC[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O nan
164611733 184259 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Antagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay
ChEMBL 2566 84 43 36 -12.7 CC[C@H](C)[C@H](NC(=O)CNC(C)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(N)=O)C(C)C)[C@@H](C)O nan
CHEMBL4852279 184259 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Antagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay
ChEMBL 2566 84 43 36 -12.7 CC[C@H](C)[C@H](NC(=O)CNC(C)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(N)=O)C(C)C)[C@@H](C)O nan
164615482 183967 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Antagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay
ChEMBL 1565 50 24 23 -7.1 CC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(N)=O)[C@@H](C)O nan
CHEMBL4848198 183967 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Antagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay
ChEMBL 1565 50 24 23 -7.1 CC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(N)=O)[C@@H](C)O nan