Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 164609465 | 184585 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 2 | Agonist activity at frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells by luciferase reporter gene assayAgonist activity at frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells by luciferase reporter gene assay |
ChEMBL | 1425 | 27 | 21 | 24 | -9.2 | CSCC[C@@H]1NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)O)NC1=O | nan | ||
| CHEMBL4847020 | 184585 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 2 | Agonist activity at frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells by luciferase reporter gene assayAgonist activity at frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells by luciferase reporter gene assay |
ChEMBL | 1425 | 27 | 21 | 24 | -9.2 | CSCC[C@@H]1NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)O)NC1=O | nan | ||
| 164610002 | 184754 | None | 0 | Human | Functional | pIC50 | = | 10 | 10.0 | -5 | 4 | Antagonist activity at Wnt3a-stimulated frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay |
ChEMBL | 1427 | 49 | 23 | 24 | -9.7 | CSCC[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O | nan | ||
| CHEMBL4849630 | 184754 | None | 0 | Human | Functional | pIC50 | = | 10 | 10.0 | -5 | 4 | Antagonist activity at Wnt3a-stimulated frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated frizzled-2 (unknown origin) expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay |
ChEMBL | 1427 | 49 | 23 | 24 | -9.7 | CSCC[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O | nan | ||
| 10197 | 3972 | None | 0 | Human | Functional | pIC50 | ~ | 9.0 | 9.0 | -1 | 5 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 22753465 | ||||
Showing 1 to 5 of 5 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 164610002 | 184754 | None | 0 | Rat | Binding | pIC50 | = | 10.8 | 10.8 | - | 0 | Antagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay |
ChEMBL | 1427 | 49 | 23 | 24 | -9.7 | CSCC[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O | nan | ||
| CHEMBL4849630 | 184754 | None | 0 | Rat | Binding | pIC50 | = | 10.8 | 10.8 | - | 0 | Antagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay |
ChEMBL | 1427 | 49 | 23 | 24 | -9.7 | CSCC[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O | nan | ||
| 164611733 | 184948 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | Antagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay |
ChEMBL | 2566 | 84 | 43 | 36 | -12.7 | CC[C@H](C)[C@H](NC(=O)CNC(C)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(N)=O)C(C)C)[C@@H](C)O | nan | ||
| CHEMBL4852279 | 184948 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | Antagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay |
ChEMBL | 2566 | 84 | 43 | 36 | -12.7 | CC[C@H](C)[C@H](NC(=O)CNC(C)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(N)=O)C(C)C)[C@@H](C)O | nan | ||
| 164615482 | 184656 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Antagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay |
ChEMBL | 1565 | 50 | 24 | 23 | -7.1 | CC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(N)=O)[C@@H](C)O | nan | ||
| CHEMBL4848198 | 184656 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Antagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assayAntagonist activity at Wnt3a-stimulated rat frizzled-2 expressed in human HEK293superTOP flash cells incubated for 24 hrs by luciferase reporter gene assay |
ChEMBL | 1565 | 50 | 24 | 23 | -7.1 | CC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(N)=O)[C@@H](C)O | nan | ||
Showing 1 to 6 of 6 entries