GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	10197	3909	0	None	-14	5	Human	8.0	pIC50	~	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	22753465

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	2554	784	115	None	-81	7	Mouse	4.8	pKd	=	4.8	Binding	Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assayBinding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay	ChEMBL	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	10.1021/acs.jmedchem.9b02020
	489	784	115	None	-81	7	Mouse	4.8	pKd	=	4.8	Binding	Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assayBinding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay	ChEMBL	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	10.1021/acs.jmedchem.9b02020
	5339	784	115	None	-81	7	Mouse	4.8	pKd	=	4.8	Binding	Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assayBinding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay	ChEMBL	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	10.1021/acs.jmedchem.9b02020
	CHEMBL108	784	115	None	-81	7	Mouse	4.8	pKd	=	4.8	Binding	Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assayBinding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay	ChEMBL	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	10.1021/acs.jmedchem.9b02020
	DB00564	784	115	None	-81	7	Mouse	4.8	pKd	=	4.8	Binding	Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assayBinding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay	ChEMBL	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	10.1021/acs.jmedchem.9b02020
	2554	784	115	None	-1	7	Human	8.3	pKd	=	8.3	Binding	Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.	Drug Central	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
	489	784	115	None	-1	7	Human	8.3	pKd	=	8.3	Binding	Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.	Drug Central	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
	5339	784	115	None	-1	7	Human	8.3	pKd	=	8.3	Binding	Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.	Drug Central	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
	CHEMBL108	784	115	None	-1	7	Human	8.3	pKd	=	8.3	Binding	Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.	Drug Central	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
	DB00564	784	115	None	-1	7	Human	8.3	pKd	=	8.3	Binding	Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.	Drug Central	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
	2554	784	115	None	-1	7	Human	4.8	pKd	=	4.8	Binding	Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.	Guide to Pharmacology	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	32049522
	489	784	115	None	-1	7	Human	4.8	pKd	=	4.8	Binding	Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.	Guide to Pharmacology	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	32049522
	5339	784	115	None	-1	7	Human	4.8	pKd	=	4.8	Binding	Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.	Guide to Pharmacology	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	32049522
	CHEMBL108	784	115	None	-1	7	Human	4.8	pKd	=	4.8	Binding	Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.	Guide to Pharmacology	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	32049522
	DB00564	784	115	None	-1	7	Human	4.8	pKd	=	4.8	Binding	Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.	Guide to Pharmacology	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	32049522