Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
aa3r_human 317 C-term S => GlyfsTer9 frameshift 0.0003229 39 120768 0 None None
aa3r_human 265 7.36x35 TM7 Y => Ter stop gained 8.322e-06 1 120166 0 None None
aa3r_human 227 6.32x32 TM6 K => Ter stop gained 8.245e-06 1 121286 0 None None GP (contact)
aa3r_human 199 5.60x60 TM5 D => SerfsTer13 frameshift 8.238e-06 1 121382 0 None None
aa3r_human 174 5.35x37 TM5 M => Ter frameshift 8.239e-06 1 121374 0 None None LB (hydrophobic, Van der Waals)
aa3r_human 161 ECL2 V => GlyfsTer34 frameshift 8.328e-06 1 120080 0 None None
aa3r_human 121 34.56x56 ICL2 V => LeufsTer12 frameshift 8.332e-06 1 120020 0 None None GP (contact)
aa3r_human 175 5.36x38 TM5 D => ThrfsTer36 frameshift 8.237e-06 1 121404 0 None None
aa3r_human 166 45.50x50 ECL2 C => Ter stop gained 8.237e-06 1 121410 0 None None
aa3r_human 124 4.39x39 TM4 H => GlnfsTer75 frameshift 8.274e-06 1 120862 0 None None
aa3r_human 108 3.50x50 TM3 R => Ter stop gained 2.492e-05 3 120368 0 None None SodiumPocket MicroSwitch GP (contact)
aa3r_human 95 3.37x37 TM3 H => ArgfsTer64 frameshift 8.27e-06 1 120918 0 None None LB (Van der Waals)
aa3r_human 81 3.23x23 TM3 Y => Ter stop gained 0.000124 15 120990 0 None None
aa3r_human 20 1.40x40 TM1 I => Ter stop gained 1.657e-05 2 120670 0 None None
aa3r_human 10 1.30x30 TM1 L => Ter stop gained 8.284e-06 1 120718 0 None None
aa3r_human 316 C-term N => Y missense 2.478e-05 3 121052 0 0.03 0.054
aa3r_human 315 C-term K => N missense 8.258e-06 1 121090 0 0.15 0.014
aa3r_human 314 C-term E => G missense 8.252e-06 1 121182 0 0.14 0.033
aa3r_human 311 C-term T => K missense 8.245e-06 1 121292 0 0.69 0.021
aa3r_human 311 C-term T => A missense 8.244e-06 1 121300 0 0.57 0.008
aa3r_human 309 C-term L => S missense 8.242e-06 1 121324 0 0.11 0.003
aa3r_human 307 8.68x68 H8 D => Y missense 0.0001071 13 121344 1 0.01 0.429
aa3r_human 305 8.66x66 H8 P => L missense 9.063e-05 11 121368 0 0.19 0.002
aa3r_human 303 8.64x64 H8 C => F missense 8.239e-06 1 121376 0 0.02 0.838
aa3r_human 300 8.61x61 H8 C => S missense 8.238e-06 1 121384 0 0.21 0.013
aa3r_human 296 8.57x57 H8 I => N missense 8.239e-06 1 121372 0 0.0 0.99
aa3r_human 296 8.57x57 H8 I => V missense 8.239e-06 1 121370 0 0.03 0.685
aa3r_human 294 8.55x55 H8 L => F missense 1.648e-05 2 121360 0 0.59 0.005
aa3r_human 293 8.54x54 H8 Y => C missense 8.24e-06 1 121356 0 0.08 0.093
aa3r_human 293 8.54x54 H8 Y => H missense 1.648e-05 2 121360 0 0.0 0.94
aa3r_human 289 8.50x50 H8 F => L missense 1.648e-05 2 121356 0 0.0 0.967
aa3r_human 282 7.53x53 TM7 Y => C missense 8.24e-06 1 121354 0 0.0 1.0 SodiumPocket MicroSwitch
aa3r_human 281 7.52x52 TM7 V => G missense 8.24e-06 1 121354 0 0.0 0.962
aa3r_human 281 7.52x52 TM7 V => I missense 2.472e-05 3 121352 0 0.42 0.08
aa3r_human 273 7.44x43 TM7 A => V missense 8.241e-06 1 121348 0 0.18 0.531 SodiumPocket MicroSwitch
aa3r_human 268 7.39x38 TM7 I => V missense 4.945e-05 6 121344 0 0.0 0.921 LB (hydrophobic, Van der Waals)
aa3r_human 267 7.38x37 TM7 G => D missense 4.946e-05 6 121320 0 0.0 0.914
aa3r_human 266 7.37x36 TM7 M => K missense 0.0178 2160 121322 35 0.0 0.012
aa3r_human 259 ECL3 V => L missense 8.243e-06 1 121312 0 0.33 0.168
aa3r_human 257 ECL3 G => S missense 8.244e-06 1 121306 0 0.79 0.014
aa3r_human 254 6.59x59 TM6 Y => H missense 8.244e-06 1 121306 0 0.1 0.188
aa3r_human 251 6.56x56 TM6 C => G missense 0.0005276 64 121304 0 0.0 0.934
aa3r_human 250 6.55x55 TM6 N => S missense 9.068e-05 11 121300 0 0.01 0.913 LB (polar (hydrogen bond), Van der Waals)
aa3r_human 249 6.54x54 TM6 I => V missense 8.244e-06 1 121304 0 0.03 0.021
aa3r_human 248 6.53x53 TM6 I => L missense 0.0947 11483 121256 707 0.0 0.9
aa3r_human 244 6.49x49 TM6 L => Q missense 8.245e-06 1 121282 0 0.0 0.998
aa3r_human 236 6.41x41 TM6 L => I missense 8.245e-06 1 121290 0 0.01 0.679
aa3r_human 232 6.37x37 TM6 L => F missense 8.245e-06 1 121290 0 0.0 0.951 GP (contact)
aa3r_human 232 6.37x37 TM6 L => S missense 1.649e-05 2 121294 0 0.0 0.998 GP (contact)
aa3r_human 231 6.36x36 TM6 S => F missense 8.245e-06 1 121288 0 0.0 0.979 GP (contact)
aa3r_human 228 6.33x33 TM6 T => M missense 5.773e-05 7 121264 0 0.26 0.418 GP (contact)
aa3r_human 224 6.29x29 TM6 R => Q missense 9.071e-05 11 121260 0 0.16 0.219 GP (contact)
aa3r_human 224 6.29x29 TM6 R => W missense 3.299e-05 4 121264 0 0.0 0.132 GP (contact)
aa3r_human 222 6.27x27 TM6 Y => H missense 8.246e-06 1 121274 0 0.06 0.984
aa3r_human 221 6.26x26 TM6 F => L missense 1.649e-05 2 121274 0 0.16 0.088 GP (contact)
aa3r_human 216 ICL3 K => R missense 1.649e-05 2 121280 0 0.75 0.004
aa3r_human 215 ICL3 S => C missense 8.246e-06 1 121272 0 0.19 0.287
aa3r_human 212 5.73x73 TM5 L => S missense 8.245e-06 1 121286 0 0.53 0.007
aa3r_human 205 5.66x66 TM5 R => Q missense 2.473e-05 3 121306 0 0.07 0.903 GP (contact)
aa3r_human 205 5.66x66 TM5 R => W missense 1.649e-05 2 121308 0 0.15 0.785 GP (contact)
aa3r_human 197 5.58x58 TM5 Y => F missense 8.24e-06 1 121356 0 0.0 1.0 SodiumPocket MicroSwitch
aa3r_human 197 5.58x58 TM5 Y => H missense 8.24e-06 1 121358 0 0.0 1.0 SodiumPocket MicroSwitch
aa3r_human 195 5.56x56 TM5 A => D missense 8.24e-06 1 121364 0 0.01 0.873
aa3r_human 195 5.56x56 TM5 A => T missense 0.0004614 56 121364 0 0.1 0.124
aa3r_human 193 5.54x54 TM5 M => T missense 2.472e-05 3 121368 0 0.0 0.956
aa3r_human 191 5.52x52 TM5 V => I missense 4.944e-05 6 121370 0 0.19 0.012
aa3r_human 190 5.51x51 TM5 L => P missense 8.239e-06 1 121376 0 0.0 0.997
aa3r_human 189 5.50x50 TM5 P => H missense 8.239e-06 1 121374 0 0.0 1.0 SodiumPocket MicroSwitch
aa3r_human 186 5.47x47 TM5 I => V missense 8.238e-06 1 121384 0 1.0 0.07 SodiumPocket MicroSwitch
aa3r_human 184 5.45x46 TM5 T => P missense 4.119e-05 5 121394 0 0.17 0.74
aa3r_human 181 5.42x43 TM5 S => G missense 1.648e-05 2 121396 0 0.16 0.316
aa3r_human 180 5.41x42 TM5 F => L missense 1.647e-05 2 121398 0 0.05 0.366
aa3r_human 179 5.40x411 TM5 Y => S missense 8.238e-06 1 121396 0 0.0 0.803
aa3r_human 178 5.39x41 TM5 V => I missense 8.237e-06 1 121398 0 0.03 0.968
aa3r_human 177 5.38x40 TM5 M => V missense 8.237e-06 1 121400 0 0.18 0.665 LB (hydrophobic, Van der Waals)
aa3r_human 176 5.37x39 TM5 Y => C missense 8.237e-06 1 121406 0 0.0 1.0
aa3r_human 174 5.35x37 TM5 M => T missense 8.237e-06 1 121406 0 0.03 0.292 LB (hydrophobic, Van der Waals)
aa3r_human 172 ECL2 M => I missense 8.237e-06 1 121404 0 0.63 0.009
aa3r_human 172 ECL2 M => T missense 8.237e-06 1 121406 0 0.0 0.098
aa3r_human 171 ECL2 V => I missense 0.0004201 51 121404 0 0.02 0.595
aa3r_human 170 ECL2 S => F missense 1.647e-05 2 121408 0 0.0 0.099
aa3r_human 164 ECL2 L => F missense 8.237e-06 1 121408 0 0.08 0.033
aa3r_human 154 ECL2 T => I missense 8.237e-06 1 121410 0 0.25 0.009
aa3r_human 146 4.61x61 TM4 M => I missense 1.647e-05 2 121410 0 0.01 0.141
aa3r_human 146 4.61x61 TM4 M => T missense 8.237e-06 1 121410 0 0.0 0.735
aa3r_human 146 4.61x61 TM4 M => K missense 3.295e-05 4 121410 0 0.0 0.821
aa3r_human 133 4.48x48 TM4 L => F missense 8.249e-06 1 121232 0 0.09 0.208
aa3r_human 131 4.46x46 TM4 L => P missense 8.267e-06 1 120966 0 0.0 0.986
aa3r_human 129 4.44x44 TM4 L => V missense 4.128e-05 5 121118 0 1.0 0.05
aa3r_human 122 34.57x57 ICL2 T => A missense 1.662e-05 2 120350 0 0.05 0.042 GP (contact)
aa3r_human 120 34.55x55 ICL2 R => S missense 1.665e-05 2 120112 0 0.74 0.023 GP (contact)
aa3r_human 116 34.51x51 ICL2 V => I missense 1.687e-05 2 118582 0 nan 0.02 GP (contact)
aa3r_human 114 3.56x56 TM3 L => P missense 3.353e-05 4 119292 0 nan 0.999 GP (contact)
aa3r_human 111 3.53x53 TM3 R => Q missense 8.349e-06 1 119770 0 0.01 0.999 GP (contact)
aa3r_human 111 3.53x53 TM3 R => W missense 3.338e-05 4 119836 0 0.01 1.0 GP (contact)
aa3r_human 108 3.50x50 TM3 R => Q missense 6.65e-05 8 120292 0 0.0 0.999 SodiumPocket MicroSwitch GP (contact)
aa3r_human 105 3.47x47 TM3 A => T missense 8.291e-06 1 120608 0 nan 0.908
aa3r_human 102 3.44x44 TM3 L => R missense 8.28e-06 1 120780 0 nan 1.0
aa3r_human 99 3.41x41 TM3 M => R missense 8.274e-06 1 120856 0 nan 0.952
aa3r_human 96 3.38x38 TM3 A => V missense 1.654e-05 2 120904 0 0.01 0.999
aa3r_human 96 3.38x38 TM3 A => G missense 8.271e-06 1 120904 0 nan 0.999
aa3r_human 96 3.38x38 TM3 A => T missense 2.481e-05 3 120908 0 nan 0.999
aa3r_human 90 3.32x32 TM3 L => V missense 0.004133 500 120978 11 nan 0.02
aa3r_human 84 3.26x26 TM3 L => H missense 1.653e-05 2 120996 0 nan 1.0
aa3r_human 77 23.51x51 ECL1 T => R missense 5.785e-05 7 120998 0 nan 0.014
aa3r_human 77 23.51x51 ECL1 T => I missense 1.653e-05 2 120998 0 nan 0.043
aa3r_human 69 2.61x60 TM2 A => D missense 8.26e-06 1 121072 0 nan 0.995
aa3r_human 67 2.59x58 TM2 P => H missense 8.258e-06 1 121098 0 nan 1.0
aa3r_human 66 2.58x57 TM2 M => L missense 8.258e-06 1 121102 0 nan 0.378
aa3r_human 64 2.56x551 TM2 L => P missense 1.651e-05 2 121108 0 nan 0.998
aa3r_human 61 2.53x53 TM2 V => A missense 8.258e-06 1 121100 0 0.0 0.996
aa3r_human 53 2.45x45 TM2 S => C missense 8.261e-06 1 121058 0 0.0 1.0
aa3r_human 51 2.43x43 TM2 I => S missense 1.653e-05 2 121022 0 nan 0.995
aa3r_human 49 2.41x41 TM2 Y => D missense 8.266e-06 1 120982 0 nan 0.993
aa3r_human 48 2.40x40 TM2 F => L missense 8.267e-06 1 120964 0 nan 0.348
aa3r_human 47 2.39x39 TM2 T => N missense 8.269e-06 1 120934 0 nan 0.999
aa3r_human 45 2.37x37 TM2 T => N missense 8.273e-06 1 120878 0 nan 0.026
aa3r_human 42 12.49x49 ICL1 S => N missense 8.282e-06 1 120742 0 0.05 0.924
aa3r_human 37 1.57x57 TM1 V => G missense 8.3e-06 1 120484 0 nan 0.979
aa3r_human 36 1.56x56 TM1 V => M missense 0.0001329 16 120374 0 0.0 0.903
aa3r_human 31 1.51x51 TM1 V => M missense 0.0002002 24 119852 0 0.05 0.149
aa3r_human 31 1.51x51 TM1 V => L missense 1.669e-05 2 119852 0 0.03 0.039
aa3r_human 27 1.47x47 TM1 I => L missense 8.399e-06 1 119058 0 nan 0.143
aa3r_human 22 1.42x42 TM1 I => T missense 8.48e-05 10 117926 0 nan 0.995
aa3r_human 18 1.38x38 TM1 M => V missense 8.621e-06 1 115998 0 0.55 0.001
aa3r_human 10 1.30x30 TM1 L => M missense 9.29e-06 1 107646 0 nan 0.046
aa3r_human 8 N-term L => V missense 9.604e-06 1 104122 0 0.24 0.004
aa3r_human 7 N-term A => V missense 9.662e-06 1 103498 0 nan 0.047
aa3r_human 6 N-term T => S missense 0.0001282 13 101426 0 nan 0.112
aa3r_human 5 N-term S => R missense 1.01e-05 1 99050 0 nan 0.675
aa3r_human 5 N-term S => C missense 1.018e-05 1 98238 0 nan 0.896
aa3r_human 2 N-term P => L missense 1.102e-05 1 90722 0 nan 0.033


Residue

Diagrams

ICL1 P S L Q ICL1ECL1 I T I ECL1ICL2 T V R Y K R V T ICL2ECL2 W N M K L T S E Y H R N V T F L S C Q F V S V M ECL2ICL3 S N S K ICL3ECL3 G E V ECL3N-term M P N N S T A L N-termC-term L D T S I E K N S E C-term S L A N V T Y I T M E I F I G L C A I V G N V L V I C V V K L N T T T F Y F I V S L A L A D I A V G V L V M P L A I V V S L G H F Y S C L F M T C L L L I F T H A S I M S L L A I A V D R Y L R V K L T H R R I W L A L G L C W L V S F L V G L T P M F G R M D Y M V Y F S F L T W I F I P L V V M C A I Y L D I F Y I I R N K L S L N L E T G A F Y G R E F K T A K S L F L V L F L F A L S W L P L S I I N C I I Y F N P Q L V L Y M G I L L S H A N S M M N P I V Y A Y K I K K Y L L C V V D S F K E T I L K A C H P S
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