Variation Browser
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Receptor |
Position |
GPCRdb |
Segment |
Variant |
Mutation type |
Allele Frequency |
Allele Count |
Allele Number |
Homozygotes |
SIFT score |
PolyPhen score |
Functional annotation |
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Receptor |
Position |
GPCRdb |
Segment |
Variant |
Mutation Type |
Allele Frequency |
Allele Count |
Allele Number |
Homozygotes |
SIFT score |
PolyPhen score |
Functional annotation |
acm4_human |
476 |
|
C-term |
G => S |
missense |
9.225e-06 |
1 |
108402 |
0 |
nan |
0.895 |
|
acm4_human |
473 |
|
C-term |
R => Q |
missense |
2.606e-05 |
3 |
115098 |
0 |
0.04 |
0.354 |
|
acm4_human |
473 |
|
C-term |
R => W |
missense |
8.63e-06 |
1 |
115876 |
0 |
0.0 |
0.918 |
|
acm4_human |
465 |
8.55x55 |
H8 |
R => W |
missense |
0.0003596 |
43 |
119582 |
0 |
0.0 |
0.654 |
|
acm4_human |
444 |
7.44x43 |
TM7 |
V => I |
missense |
1.661e-05 |
2 |
120436 |
0 |
0.73 |
0.386 |
SodiumPocket MicroSwitch |
acm4_human |
418 |
6.53x53 |
TM6 |
V => I |
missense |
2.493e-05 |
3 |
120342 |
0 |
1.0 |
0.954 |
|
acm4_human |
414 |
6.49x49 |
TM6 |
T => M |
missense |
2.495e-05 |
3 |
120242 |
0 |
0.01 |
0.999 |
|
acm4_human |
411 |
6.46x46 |
TM6 |
L => F |
missense |
8.313e-06 |
1 |
120296 |
0 |
0.01 |
0.02 |
|
acm4_human |
396 |
6.31x31 |
TM6 |
R => C |
missense |
8.338e-06 |
1 |
119926 |
0 |
0.0 |
0.969 |
|
acm4_human |
394 |
6.29x29 |
TM6 |
R => W |
missense |
8.341e-06 |
1 |
119896 |
0 |
0.02 |
0.979 |
GP (contact) |
acm4_human |
393 |
6.28x28 |
TM6 |
A => V |
missense |
8.344e-06 |
1 |
119850 |
0 |
1.0 |
0.643 |
GP (contact) |
acm4_human |
393 |
6.28x28 |
TM6 |
A => D |
missense |
8.344e-06 |
1 |
119850 |
0 |
0.03 |
0.889 |
GP (contact) |
acm4_human |
389 |
6.24x24 |
TM6 |
R => Q |
missense |
8.342e-06 |
1 |
119882 |
0 |
0.01 |
0.658 |
|
acm4_human |
386 |
|
ICL3 |
R => H |
missense |
8.34e-06 |
1 |
119906 |
0 |
0.04 |
0.93 |
|
acm4_human |
384 |
|
ICL3 |
Q => E |
missense |
8.337e-06 |
1 |
119952 |
0 |
0.3 |
0.101 |
|
acm4_human |
378 |
|
ICL3 |
A => T |
missense |
1.668e-05 |
2 |
119898 |
0 |
0.21 |
0.643 |
|
acm4_human |
375 |
|
ICL3 |
R => L |
missense |
8.344e-06 |
1 |
119842 |
0 |
0.13 |
0.77 |
|
acm4_human |
375 |
|
ICL3 |
R => H |
missense |
8.344e-06 |
1 |
119842 |
0 |
0.02 |
0.973 |
|
acm4_human |
375 |
|
ICL3 |
R => C |
missense |
8.349e-06 |
1 |
119778 |
0 |
0.01 |
0.745 |
|
acm4_human |
373 |
|
ICL3 |
V => M |
missense |
2.505e-05 |
3 |
119780 |
0 |
0.25 |
0.992 |
|
acm4_human |
370 |
|
ICL3 |
A => V |
missense |
8.363e-06 |
1 |
119572 |
0 |
0.24 |
0.227 |
|
acm4_human |
368 |
|
ICL3 |
R => H |
missense |
1.677e-05 |
2 |
119270 |
0 |
0.1 |
0.066 |
|
acm4_human |
368 |
|
ICL3 |
R => C |
missense |
8.384e-06 |
1 |
119278 |
0 |
0.03 |
0.892 |
|
acm4_human |
367 |
|
ICL3 |
M => T |
missense |
0.0001175 |
14 |
119112 |
0 |
0.57 |
0.0 |
|
acm4_human |
364 |
|
ICL3 |
P => L |
missense |
4.234e-05 |
5 |
118096 |
0 |
0.28 |
0.066 |
|
acm4_human |
364 |
|
ICL3 |
P => Q |
missense |
2.54e-05 |
3 |
118096 |
0 |
0.33 |
0.339 |
|
acm4_human |
363 |
|
ICL3 |
T => M |
missense |
6.778e-05 |
8 |
118024 |
0 |
0.1 |
0.153 |
|
acm4_human |
362 |
|
ICL3 |
A => V |
missense |
8.487e-06 |
1 |
117824 |
0 |
0.26 |
0.216 |
|
acm4_human |
359 |
|
ICL3 |
I => T |
missense |
8.539e-06 |
1 |
117108 |
0 |
0.33 |
0.145 |
|
acm4_human |
350 |
|
ICL3 |
G => S |
missense |
8.727e-06 |
1 |
114590 |
0 |
0.23 |
0.88 |
|
acm4_human |
349 |
|
ICL3 |
T => R |
missense |
8.743e-06 |
1 |
114372 |
0 |
0.48 |
0.296 |
|
acm4_human |
346 |
|
ICL3 |
T => M |
missense |
7.923e-05 |
9 |
113590 |
0 |
0.04 |
0.998 |
|
acm4_human |
344 |
|
ICL3 |
I => T |
missense |
8.829e-06 |
1 |
113264 |
0 |
0.26 |
0.395 |
|
acm4_human |
341 |
|
ICL3 |
K => R |
missense |
8.886e-06 |
1 |
112540 |
0 |
0.33 |
0.159 |
|
acm4_human |
331 |
|
ICL3 |
R => Q |
missense |
9.053e-06 |
1 |
110460 |
0 |
0.6 |
0.066 |
|
acm4_human |
331 |
|
ICL3 |
R => P |
missense |
9.053e-06 |
1 |
110460 |
0 |
0.29 |
0.023 |
|
acm4_human |
328 |
|
ICL3 |
L => P |
missense |
9.086e-06 |
1 |
110060 |
0 |
0.28 |
0.006 |
|
acm4_human |
327 |
|
ICL3 |
P => L |
missense |
9.103e-06 |
1 |
109858 |
0 |
0.11 |
0.001 |
|
acm4_human |
326 |
|
ICL3 |
P => L |
missense |
9.106e-06 |
1 |
109818 |
0 |
0.4 |
0.145 |
|
acm4_human |
323 |
|
ICL3 |
M => V |
missense |
9.181e-06 |
1 |
108924 |
0 |
0.68 |
0.0 |
|
acm4_human |
322 |
|
ICL3 |
A => S |
missense |
9.186e-06 |
1 |
108864 |
0 |
0.89 |
0.007 |
|
acm4_human |
322 |
|
ICL3 |
A => T |
missense |
1.837e-05 |
2 |
108864 |
0 |
0.62 |
0.013 |
|
acm4_human |
316 |
|
ICL3 |
T => P |
missense |
9.218e-06 |
1 |
108484 |
0 |
0.31 |
0.005 |
|
acm4_human |
308 |
|
ICL3 |
R => H |
missense |
9.256e-06 |
1 |
108040 |
0 |
0.11 |
0.666 |
|
acm4_human |
308 |
|
ICL3 |
R => C |
missense |
1.852e-05 |
2 |
107994 |
0 |
0.06 |
0.86 |
|
acm4_human |
304 |
|
ICL3 |
N => D |
missense |
9.273e-06 |
1 |
107844 |
0 |
0.54 |
0.247 |
|
acm4_human |
287 |
|
ICL3 |
V => M |
missense |
9.615e-06 |
1 |
104008 |
0 |
0.24 |
0.029 |
|
acm4_human |
285 |
|
ICL3 |
R => H |
missense |
9.772e-06 |
1 |
102332 |
0 |
0.19 |
0.734 |
|
acm4_human |
285 |
|
ICL3 |
R => C |
missense |
5.956e-05 |
6 |
100746 |
0 |
0.05 |
0.022 |
|
acm4_human |
282 |
|
ICL3 |
P => L |
missense |
6.1e-05 |
6 |
98356 |
0 |
0.27 |
0.005 |
|
acm4_human |
279 |
|
ICL3 |
A => V |
missense |
4.348e-05 |
4 |
92004 |
0 |
0.18 |
0.013 |
|
acm4_human |
277 |
|
ICL3 |
P => R |
missense |
3.418e-05 |
3 |
87766 |
0 |
0.55 |
0.029 |
|
acm4_human |
277 |
|
ICL3 |
P => L |
missense |
1.139e-05 |
1 |
87766 |
0 |
0.32 |
0.004 |
|
acm4_human |
276 |
|
ICL3 |
P => L |
missense |
1.128e-05 |
1 |
88616 |
0 |
0.3 |
0.016 |
|
acm4_human |
275 |
|
ICL3 |
A => V |
missense |
1.16e-05 |
1 |
86204 |
0 |
0.3 |
0.021 |
|
acm4_human |
273 |
|
ICL3 |
E => D |
missense |
1.174e-05 |
1 |
85156 |
0 |
0.59 |
0.006 |
|
acm4_human |
268 |
|
ICL3 |
R => C |
missense |
1.27e-05 |
1 |
78764 |
0 |
0.08 |
0.892 |
|
acm4_human |
266 |
|
ICL3 |
E => K |
missense |
1.312e-05 |
1 |
76222 |
0 |
0.9 |
0.034 |
|
acm4_human |
265 |
|
ICL3 |
E => G |
missense |
1.321e-05 |
1 |
75720 |
0 |
0.22 |
0.012 |
|
acm4_human |
265 |
|
ICL3 |
E => K |
missense |
6.638e-05 |
5 |
75328 |
0 |
0.41 |
0.012 |
|
acm4_human |
264 |
|
ICL3 |
R => Q |
missense |
9.372e-05 |
7 |
74688 |
0 |
0.65 |
0.017 |
|
acm4_human |
264 |
|
ICL3 |
R => P |
missense |
1.339e-05 |
1 |
74688 |
0 |
0.27 |
0.009 |
|
acm4_human |
263 |
|
ICL3 |
A => T |
missense |
6.835e-05 |
5 |
73152 |
0 |
0.75 |
0.108 |
|
acm4_human |
262 |
|
ICL3 |
A => V |
missense |
1.38e-05 |
1 |
72450 |
0 |
0.42 |
0.012 |
|
acm4_human |
260 |
|
ICL3 |
G => R |
missense |
5.621e-05 |
4 |
71156 |
0 |
0.58 |
0.005 |
|
acm4_human |
258 |
|
ICL3 |
P => L |
missense |
8.451e-05 |
6 |
71000 |
0 |
0.18 |
0.77 |
|
acm4_human |
254 |
|
ICL3 |
V => I |
missense |
0.0001973 |
14 |
70958 |
0 |
0.31 |
0.008 |
|
acm4_human |
246 |
|
ICL3 |
K => E |
missense |
1.368e-05 |
1 |
73074 |
0 |
0.27 |
0.009 |
|
acm4_human |
238 |
|
ICL3 |
K => Q |
missense |
1.285e-05 |
1 |
77816 |
0 |
0.56 |
0.038 |
|
acm4_human |
236 |
|
ICL3 |
E => K |
missense |
5.077e-05 |
4 |
78784 |
0 |
0.59 |
0.021 |
|
acm4_human |
234 |
|
ICL3 |
P => R |
missense |
3.742e-05 |
3 |
80176 |
0 |
0.54 |
0.01 |
|
acm4_human |
234 |
|
ICL3 |
P => S |
missense |
3.709e-05 |
3 |
80892 |
0 |
0.8 |
0.017 |
|
acm4_human |
232 |
5.75x75 |
TM5 |
E => K |
missense |
7.262e-05 |
6 |
82620 |
0 |
0.67 |
0.13 |
GP (contact) |
acm4_human |
230 |
5.73x73 |
TM5 |
R => W |
missense |
5.814e-05 |
5 |
85998 |
0 |
0.01 |
0.948 |
|
acm4_human |
229 |
5.72x72 |
TM5 |
H => R |
missense |
1.141e-05 |
1 |
87626 |
0 |
0.39 |
0.216 |
GP (contact) |
acm4_human |
228 |
5.71x71 |
TM5 |
K => N |
missense |
1.132e-05 |
1 |
88350 |
0 |
0.06 |
0.876 |
GP (contact) |
acm4_human |
226 |
5.69x69 |
TM5 |
V => A |
missense |
1.105e-05 |
1 |
90494 |
0 |
0.01 |
0.902 |
GP (contact) |
acm4_human |
225 |
5.68x68 |
TM5 |
R => Q |
missense |
1.095e-05 |
1 |
91290 |
0 |
0.0 |
0.924 |
GP (contact) |
acm4_human |
223 |
5.66x66 |
TM5 |
R => C |
missense |
1.055e-05 |
1 |
94810 |
0 |
0.0 |
0.973 |
GP (contact) |
acm4_human |
201 |
5.44x45 |
TM5 |
I => T |
missense |
9.11e-06 |
1 |
109770 |
0 |
0.0 |
0.98 |
|
acm4_human |
194 |
5.37x38 |
TM5 |
A => V |
missense |
8.914e-06 |
1 |
112180 |
0 |
1.0 |
0.764 |
|
acm4_human |
184 |
|
ECL2 |
Q => R |
missense |
8.757e-06 |
1 |
114198 |
0 |
0.0 |
0.063 |
|
acm4_human |
183 |
|
ECL2 |
N => K |
missense |
8.753e-06 |
1 |
114252 |
0 |
0.3 |
0.01 |
|
acm4_human |
182 |
|
ECL2 |
D => N |
missense |
8.761e-06 |
1 |
114142 |
0 |
0.05 |
0.42 |
|
acm4_human |
155 |
4.48x48 |
TM4 |
A => V |
missense |
8.641e-06 |
1 |
115724 |
0 |
0.13 |
0.443 |
|
acm4_human |
155 |
4.48x48 |
TM4 |
A => T |
missense |
8.638e-06 |
1 |
115770 |
0 |
0.06 |
0.938 |
|
acm4_human |
143 |
34.56x56 |
ICL2 |
R => Q |
missense |
2.561e-05 |
3 |
117122 |
0 |
0.0 |
0.557 |
GP (contact) |
acm4_human |
143 |
34.56x56 |
ICL2 |
R => W |
missense |
8.538e-06 |
1 |
117126 |
0 |
0.0 |
0.427 |
GP (contact) |
acm4_human |
134 |
3.54x54 |
TM3 |
V => I |
missense |
8.461e-06 |
1 |
118184 |
0 |
0.78 |
0.958 |
GP (contact) |
acm4_human |
114 |
3.34x34 |
TM3 |
V => M |
missense |
8.347e-06 |
1 |
119808 |
0 |
0.0 |
0.999 |
|
acm4_human |
102 |
3.22x22 |
TM3 |
A => G |
missense |
8.334e-06 |
1 |
119992 |
0 |
0.24 |
0.854 |
|
acm4_human |
102 |
3.22x22 |
TM3 |
A => T |
missense |
8.333e-06 |
1 |
119998 |
0 |
1.0 |
0.354 |
|
acm4_human |
97 |
23.49x49 |
ECL1 |
Y => F |
missense |
8.33e-06 |
1 |
120046 |
0 |
0.08 |
0.049 |
|
acm4_human |
93 |
2.65x64 |
TM2 |
I => T |
missense |
8.329e-06 |
1 |
120058 |
0 |
0.06 |
0.145 |
|
acm4_human |
91 |
2.63x62 |
TM2 |
V => A |
missense |
8.33e-06 |
1 |
120052 |
0 |
0.18 |
0.887 |
|
acm4_human |
83 |
2.55x55 |
TM2 |
A => V |
missense |
4.997e-05 |
6 |
120062 |
0 |
1.0 |
0.004 |
|
acm4_human |
83 |
2.55x55 |
TM2 |
A => G |
missense |
8.329e-06 |
1 |
120062 |
0 |
0.0 |
0.646 |
|
acm4_human |
83 |
2.55x55 |
TM2 |
A => T |
missense |
8.332e-06 |
1 |
120026 |
0 |
0.08 |
0.403 |
|
acm4_human |
69 |
2.41x41 |
TM2 |
Y => N |
missense |
8.326e-06 |
1 |
120104 |
0 |
0.0 |
1.0 |
|
acm4_human |
58 |
1.58x58 |
TM1 |
K => N |
missense |
8.322e-06 |
1 |
120170 |
0 |
0.0 |
0.951 |
|
acm4_human |
42 |
1.42x42 |
TM1 |
L => Q |
missense |
8.309e-06 |
1 |
120356 |
0 |
0.0 |
0.996 |
|
acm4_human |
35 |
1.35x35 |
TM1 |
I => T |
missense |
8.306e-06 |
1 |
120398 |
0 |
0.0 |
0.992 |
|
acm4_human |
34 |
1.34x34 |
TM1 |
F => L |
missense |
8.306e-06 |
1 |
120402 |
0 |
1.0 |
0.071 |
|
acm4_human |
29 |
1.29x29 |
TM1 |
T => M |
missense |
0.0002908 |
35 |
120374 |
0 |
0.1 |
0.368 |
|
acm4_human |
26 |
1.26x26 |
TM1 |
R => H |
missense |
1.661e-05 |
2 |
120382 |
0 |
0.28 |
0.003 |
|
acm4_human |
20 |
|
N-term |
T => M |
missense |
0.0001995 |
24 |
120288 |
0 |
0.1 |
0.191 |
|
acm4_human |
18 |
|
N-term |
L => M |
missense |
8.317e-06 |
1 |
120236 |
0 |
0.24 |
0.129 |
|
acm4_human |
17 |
|
N-term |
R => H |
missense |
1.664e-05 |
2 |
120228 |
0 |
0.13 |
0.001 |
|
acm4_human |
16 |
|
N-term |
V => M |
missense |
8.322e-05 |
10 |
120160 |
0 |
0.16 |
0.015 |
|
acm4_human |
15 |
|
N-term |
S => P |
missense |
8.326e-06 |
1 |
120112 |
0 |
0.03 |
0.543 |
|
acm4_human |
14 |
|
N-term |
Q => P |
missense |
8.332e-06 |
1 |
120014 |
0 |
0.27 |
0.003 |
|
acm4_human |
13 |
|
N-term |
N => H |
missense |
8.346e-06 |
1 |
119816 |
0 |
0.01 |
0.641 |
|
acm4_human |
11 |
|
N-term |
S => W |
missense |
8.35e-06 |
1 |
119764 |
0 |
0.12 |
0.002 |
|
acm4_human |
278 |
|
ICL3 |
P => AlafsTer12 |
frameshift |
3.391e-05 |
3 |
88478 |
0 |
None |
None |
|
acm4_human |
277 |
|
ICL3 |
P => ArgfsTer69 |
frameshift |
6.781e-05 |
6 |
88478 |
0 |
None |
None |
|
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue
Diagrams
SnakePlot Download:
PNG |
SVG
HelixBox Download:
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SVG