Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
acm4_human 278 ICL3 P => AlafsTer12 frameshift 3.391e-05 3 88478 0 None None
acm4_human 277 ICL3 P => ArgfsTer69 frameshift 6.781e-05 6 88478 0 None None
acm4_human 476 C-term G => S missense 9.225e-06 1 108402 0 nan 0.895
acm4_human 473 C-term R => Q missense 2.606e-05 3 115098 0 0.04 0.354
acm4_human 473 C-term R => W missense 8.63e-06 1 115876 0 0.0 0.918
acm4_human 465 8.55x55 H8 R => W missense 0.0003596 43 119582 0 0.0 0.654
acm4_human 444 7.44x43 TM7 V => I missense 1.661e-05 2 120436 0 0.73 0.386 SodiumPocket MicroSwitch
acm4_human 418 6.53x53 TM6 V => I missense 2.493e-05 3 120342 0 1.0 0.954
acm4_human 414 6.49x49 TM6 T => M missense 2.495e-05 3 120242 0 0.01 0.999
acm4_human 411 6.46x46 TM6 L => F missense 8.313e-06 1 120296 0 0.01 0.02
acm4_human 396 6.31x31 TM6 R => C missense 8.338e-06 1 119926 0 0.0 0.969
acm4_human 394 6.29x29 TM6 R => W missense 8.341e-06 1 119896 0 0.02 0.979 GP (contact)
acm4_human 393 6.28x28 TM6 A => V missense 8.344e-06 1 119850 0 1.0 0.643 GP (contact)
acm4_human 393 6.28x28 TM6 A => D missense 8.344e-06 1 119850 0 0.03 0.889 GP (contact)
acm4_human 389 6.24x24 TM6 R => Q missense 8.342e-06 1 119882 0 0.01 0.658
acm4_human 386 ICL3 R => H missense 8.34e-06 1 119906 0 0.04 0.93
acm4_human 384 ICL3 Q => E missense 8.337e-06 1 119952 0 0.3 0.101
acm4_human 378 ICL3 A => T missense 1.668e-05 2 119898 0 0.21 0.643
acm4_human 375 ICL3 R => L missense 8.344e-06 1 119842 0 0.13 0.77
acm4_human 375 ICL3 R => H missense 8.344e-06 1 119842 0 0.02 0.973
acm4_human 375 ICL3 R => C missense 8.349e-06 1 119778 0 0.01 0.745
acm4_human 373 ICL3 V => M missense 2.505e-05 3 119780 0 0.25 0.992
acm4_human 370 ICL3 A => V missense 8.363e-06 1 119572 0 0.24 0.227
acm4_human 368 ICL3 R => H missense 1.677e-05 2 119270 0 0.1 0.066
acm4_human 368 ICL3 R => C missense 8.384e-06 1 119278 0 0.03 0.892
acm4_human 367 ICL3 M => T missense 0.0001175 14 119112 0 0.57 0.0
acm4_human 364 ICL3 P => L missense 4.234e-05 5 118096 0 0.28 0.066
acm4_human 364 ICL3 P => Q missense 2.54e-05 3 118096 0 0.33 0.339
acm4_human 363 ICL3 T => M missense 6.778e-05 8 118024 0 0.1 0.153
acm4_human 362 ICL3 A => V missense 8.487e-06 1 117824 0 0.26 0.216
acm4_human 359 ICL3 I => T missense 8.539e-06 1 117108 0 0.33 0.145
acm4_human 350 ICL3 G => S missense 8.727e-06 1 114590 0 0.23 0.88
acm4_human 349 ICL3 T => R missense 8.743e-06 1 114372 0 0.48 0.296
acm4_human 346 ICL3 T => M missense 7.923e-05 9 113590 0 0.04 0.998
acm4_human 344 ICL3 I => T missense 8.829e-06 1 113264 0 0.26 0.395
acm4_human 341 ICL3 K => R missense 8.886e-06 1 112540 0 0.33 0.159
acm4_human 331 ICL3 R => Q missense 9.053e-06 1 110460 0 0.6 0.066
acm4_human 331 ICL3 R => P missense 9.053e-06 1 110460 0 0.29 0.023
acm4_human 328 ICL3 L => P missense 9.086e-06 1 110060 0 0.28 0.006
acm4_human 327 ICL3 P => L missense 9.103e-06 1 109858 0 0.11 0.001
acm4_human 326 ICL3 P => L missense 9.106e-06 1 109818 0 0.4 0.145
acm4_human 323 ICL3 M => V missense 9.181e-06 1 108924 0 0.68 0.0
acm4_human 322 ICL3 A => S missense 9.186e-06 1 108864 0 0.89 0.007
acm4_human 322 ICL3 A => T missense 1.837e-05 2 108864 0 0.62 0.013
acm4_human 316 ICL3 T => P missense 9.218e-06 1 108484 0 0.31 0.005
acm4_human 308 ICL3 R => H missense 9.256e-06 1 108040 0 0.11 0.666
acm4_human 308 ICL3 R => C missense 1.852e-05 2 107994 0 0.06 0.86
acm4_human 304 ICL3 N => D missense 9.273e-06 1 107844 0 0.54 0.247
acm4_human 287 ICL3 V => M missense 9.615e-06 1 104008 0 0.24 0.029
acm4_human 285 ICL3 R => H missense 9.772e-06 1 102332 0 0.19 0.734
acm4_human 285 ICL3 R => C missense 5.956e-05 6 100746 0 0.05 0.022
acm4_human 282 ICL3 P => L missense 6.1e-05 6 98356 0 0.27 0.005
acm4_human 279 ICL3 A => V missense 4.348e-05 4 92004 0 0.18 0.013
acm4_human 277 ICL3 P => R missense 3.418e-05 3 87766 0 0.55 0.029
acm4_human 277 ICL3 P => L missense 1.139e-05 1 87766 0 0.32 0.004
acm4_human 276 ICL3 P => L missense 1.128e-05 1 88616 0 0.3 0.016
acm4_human 275 ICL3 A => V missense 1.16e-05 1 86204 0 0.3 0.021
acm4_human 273 ICL3 E => D missense 1.174e-05 1 85156 0 0.59 0.006
acm4_human 268 ICL3 R => C missense 1.27e-05 1 78764 0 0.08 0.892
acm4_human 266 ICL3 E => K missense 1.312e-05 1 76222 0 0.9 0.034
acm4_human 265 ICL3 E => G missense 1.321e-05 1 75720 0 0.22 0.012
acm4_human 265 ICL3 E => K missense 6.638e-05 5 75328 0 0.41 0.012
acm4_human 264 ICL3 R => Q missense 9.372e-05 7 74688 0 0.65 0.017
acm4_human 264 ICL3 R => P missense 1.339e-05 1 74688 0 0.27 0.009
acm4_human 263 ICL3 A => T missense 6.835e-05 5 73152 0 0.75 0.108
acm4_human 262 ICL3 A => V missense 1.38e-05 1 72450 0 0.42 0.012
acm4_human 260 ICL3 G => R missense 5.621e-05 4 71156 0 0.58 0.005
acm4_human 258 ICL3 P => L missense 8.451e-05 6 71000 0 0.18 0.77
acm4_human 254 ICL3 V => I missense 0.0001973 14 70958 0 0.31 0.008
acm4_human 246 ICL3 K => E missense 1.368e-05 1 73074 0 0.27 0.009
acm4_human 238 ICL3 K => Q missense 1.285e-05 1 77816 0 0.56 0.038
acm4_human 236 ICL3 E => K missense 5.077e-05 4 78784 0 0.59 0.021
acm4_human 234 ICL3 P => R missense 3.742e-05 3 80176 0 0.54 0.01
acm4_human 234 ICL3 P => S missense 3.709e-05 3 80892 0 0.8 0.017
acm4_human 232 5.75x75 TM5 E => K missense 7.262e-05 6 82620 0 0.67 0.13 GP (contact)
acm4_human 230 5.73x73 TM5 R => W missense 5.814e-05 5 85998 0 0.01 0.948
acm4_human 229 5.72x72 TM5 H => R missense 1.141e-05 1 87626 0 0.39 0.216 GP (contact)
acm4_human 228 5.71x71 TM5 K => N missense 1.132e-05 1 88350 0 0.06 0.876 GP (contact)
acm4_human 226 5.69x69 TM5 V => A missense 1.105e-05 1 90494 0 0.01 0.902 GP (contact)
acm4_human 225 5.68x68 TM5 R => Q missense 1.095e-05 1 91290 0 0.0 0.924 GP (contact)
acm4_human 223 5.66x66 TM5 R => C missense 1.055e-05 1 94810 0 0.0 0.973 GP (contact)
acm4_human 201 5.44x45 TM5 I => T missense 9.11e-06 1 109770 0 0.0 0.98
acm4_human 194 5.37x38 TM5 A => V missense 8.914e-06 1 112180 0 1.0 0.764
acm4_human 184 ECL2 Q => R missense 8.757e-06 1 114198 0 0.0 0.063
acm4_human 183 ECL2 N => K missense 8.753e-06 1 114252 0 0.3 0.01
acm4_human 182 ECL2 D => N missense 8.761e-06 1 114142 0 0.05 0.42
acm4_human 155 4.48x48 TM4 A => V missense 8.641e-06 1 115724 0 0.13 0.443
acm4_human 155 4.48x48 TM4 A => T missense 8.638e-06 1 115770 0 0.06 0.938
acm4_human 143 34.56x56 ICL2 R => Q missense 2.561e-05 3 117122 0 0.0 0.557 GP (contact)
acm4_human 143 34.56x56 ICL2 R => W missense 8.538e-06 1 117126 0 0.0 0.427 GP (contact)
acm4_human 134 3.54x54 TM3 V => I missense 8.461e-06 1 118184 0 0.78 0.958 GP (contact)
acm4_human 114 3.34x34 TM3 V => M missense 8.347e-06 1 119808 0 0.0 0.999
acm4_human 102 3.22x22 TM3 A => G missense 8.334e-06 1 119992 0 0.24 0.854
acm4_human 102 3.22x22 TM3 A => T missense 8.333e-06 1 119998 0 1.0 0.354
acm4_human 97 23.49x49 ECL1 Y => F missense 8.33e-06 1 120046 0 0.08 0.049
acm4_human 93 2.65x64 TM2 I => T missense 8.329e-06 1 120058 0 0.06 0.145
acm4_human 91 2.63x62 TM2 V => A missense 8.33e-06 1 120052 0 0.18 0.887
acm4_human 83 2.55x55 TM2 A => V missense 4.997e-05 6 120062 0 1.0 0.004
acm4_human 83 2.55x55 TM2 A => G missense 8.329e-06 1 120062 0 0.0 0.646
acm4_human 83 2.55x55 TM2 A => T missense 8.332e-06 1 120026 0 0.08 0.403
acm4_human 69 2.41x41 TM2 Y => N missense 8.326e-06 1 120104 0 0.0 1.0
acm4_human 58 1.58x58 TM1 K => N missense 8.322e-06 1 120170 0 0.0 0.951
acm4_human 42 1.42x42 TM1 L => Q missense 8.309e-06 1 120356 0 0.0 0.996
acm4_human 35 1.35x35 TM1 I => T missense 8.306e-06 1 120398 0 0.0 0.992
acm4_human 34 1.34x34 TM1 F => L missense 8.306e-06 1 120402 0 1.0 0.071
acm4_human 29 1.29x29 TM1 T => M missense 0.0002908 35 120374 0 0.1 0.368
acm4_human 26 1.26x26 TM1 R => H missense 1.661e-05 2 120382 0 0.28 0.003
acm4_human 20 N-term T => M missense 0.0001995 24 120288 0 0.1 0.191
acm4_human 18 N-term L => M missense 8.317e-06 1 120236 0 0.24 0.129
acm4_human 17 N-term R => H missense 1.664e-05 2 120228 0 0.13 0.001
acm4_human 16 N-term V => M missense 8.322e-05 10 120160 0 0.16 0.015
acm4_human 15 N-term S => P missense 8.326e-06 1 120112 0 0.03 0.543
acm4_human 14 N-term Q => P missense 8.332e-06 1 120014 0 0.27 0.003
acm4_human 13 N-term N => H missense 8.346e-06 1 119816 0 0.01 0.641
acm4_human 11 N-term S => W missense 8.35e-06 1 119764 0 0.12 0.002


Residue

Diagrams

ICL1 R Q L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P A R R ICL2ECL2 K R T V P D N Q C F I Q F L S ECL2ICL3 G P K E K K A K T L A F L K S P L M K Q S V K K P P P G E A A R E E L R N G K L E E A P P P A L P P P P R P V A D K D T S N E S S S G S A T Q N T K E R P A T E L S T T E A T T P A M P A P P L Q P R A L N P A S R W S K I Q I V T K Q T G N E C V T A I E I V P A T P A G M R P A A N V A R K F A S I A R N Q V R K K ICL3ECL3 Q S C I ECL3N-term M A N F T P V N G S S G N Q S V R L V T S S S H N N-termC-term Y R N I G T A R C-term R Y E T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V H K H R P E R Q M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F R H Q F K K T L L L C
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