Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
cltr1_human 220 ICL3 S => IlefsTer10 frameshift 1.221e-05 1 81928 0 None None
cltr1_human 180 5.29x30 TM5 N => LysfsTer25 frameshift 1.218e-05 1 82122 0 None None
cltr1_human 130 34.52x52 ICL2 Q => Ter stop gained 2.339e-05 2 85512 0 None None GP (contact)
cltr1_human 122 3.51x51 TM3 C => Ter stop gained 1.168e-05 1 85641 0 None None
cltr1_human 65 2.46x46 TM2 L => Ter stop gained 1.15e-05 1 86924 0 None None
cltr1_human 18 1.27x27 TM1 I => Ter frameshift 1.163e-05 1 86002 0 None None
cltr1_human 336 C-term K => R missense 1.249e-05 1 80039 0 nan 0.001
cltr1_human 335 C-term C => R missense 1.243e-05 1 80449 0 nan 0.009
cltr1_human 331 C-term G => R missense 1.222e-05 1 81839 0 0.29 0.043
cltr1_human 330 C-term K => R missense 0.0003042 25 82175 0 0.23 0.002
cltr1_human 325 C-term A => T missense 0.000488 41 84014 0 0.46 0.0
cltr1_human 325 C-term A => S missense 1.19e-05 1 84014 0 0.49 0.001
cltr1_human 323 C-term K => R missense 1.184e-05 1 84470 0 0.33 0.021
cltr1_human 322 C-term R => G missense 2.358e-05 2 84801 0 0.11 0.0
cltr1_human 321 C-term P => A missense 3.528e-05 3 85036 0 0.79 0.005
cltr1_human 317 C-term V => M missense 2.326e-05 2 85980 0 0.71 0.001
cltr1_human 312 C-term H => Y missense 1.151e-05 1 86846 0 0.51 0.001
cltr1_human 308 8.56x56 H8 T => A missense 1.144e-05 1 87379 0 0.21 0.085 PTM (Phosphorylation)
cltr1_human 303 8.51x51 H8 R => T missense 1.145e-05 1 87372 0 0.0 0.994 GP (contact)
cltr1_human 298 7.56x56 TM7 S => A missense 1.144e-05 1 87394 0 0.57 0.562 GP (contact)
cltr1_human 297 7.55x55 TM7 F => V missense 1.144e-05 1 87397 0 0.0 0.979 GP (contact)
cltr1_human 287 7.45x45 TM7 N => S missense 4.574e-05 4 87450 0 0.0 1.0
cltr1_human 278 7.36x35 TM7 V => I missense 1.143e-05 1 87461 0 0.05 0.362
cltr1_human 277 7.35x34 TM7 V => L missense 1.143e-05 1 87461 0 0.05 0.973 LB (hydrophobic, Van der Waals)
cltr1_human 277 7.35x34 TM7 V => M missense 3.43e-05 3 87461 0 0.04 0.999 LB (hydrophobic, Van der Waals)
cltr1_human 266 7.24x23 TM7 P => H missense 1.143e-05 1 87499 0 0.11 0.005
cltr1_human 266 7.24x23 TM7 P => S missense 4.571e-05 4 87511 0 1.0 0.001
cltr1_human 262 6.64x64 TM6 N => S missense 1.143e-05 1 87522 0 0.74 0.005
cltr1_human 261 6.63x63 TM6 H => Y missense 1.143e-05 1 87515 0 0.99 0.334
cltr1_human 259 6.61x61 TM6 F => V missense 1.143e-05 1 87510 0 0.43 0.035
cltr1_human 253 6.55x55 TM6 R => H missense 1.143e-05 1 87503 0 0.0 1.0 LB (Van der Waals, polar (charge-assisted hydrogen bond))
cltr1_human 251 6.53x53 TM6 I => F missense 1.143e-05 1 87500 0 0.0 0.936
cltr1_human 245 6.47x47 TM6 S => T missense 5.717e-05 5 87455 0 0.38 0.613
cltr1_human 243 6.45x46 TM6 L => F missense 0.0001373 12 87429 0 0.14 0.46
cltr1_human 240 6.42x43 TM6 A => V missense 1.145e-05 1 87337 0 1.0 0.032
cltr1_human 239 6.41x42 TM6 T => I missense 1.146e-05 1 87291 0 0.07 0.223
cltr1_human 238 6.40x41 TM6 V => M missense 4.587e-05 4 87203 0 0.0 0.999
cltr1_human 236 6.38x39 TM6 M => T missense 1.148e-05 1 87124 0 0.0 0.003
cltr1_human 235 6.37x38 TM6 I => V missense 1.149e-05 1 87008 0 0.08 0.756
cltr1_human 232 6.34x35 TM6 I => V missense 1.158e-05 1 86356 0 0.68 0.013
cltr1_human 231 6.33x34 TM6 A => T missense 2.323e-05 2 86103 0 0.0 0.986 SodiumPocket MicroSwitch
cltr1_human 227 6.29x30 TM6 S => G missense 2.37e-05 2 84394 0 0.01 0.403 SodiumPocket MicroSwitch
cltr1_human 221 ICL3 M => I missense 2.42e-05 2 82650 0 0.48 0.039
cltr1_human 219 ICL3 K => N missense 1.221e-05 1 81886 0 0.68 0.001
cltr1_human 219 ICL3 K => E missense 1.221e-05 1 81910 0 1.0 0.04
cltr1_human 215 5.64x64 TM5 T => I missense 1.232e-05 1 81141 0 0.01 0.142 GP (contact)
cltr1_human 214 5.63x63 TM5 L => F missense 1.237e-05 1 80814 0 0.36 0.005
cltr1_human 212 5.61x61 TM5 I => T missense 4.958e-05 4 80684 0 0.0 0.999 GP (contact)
cltr1_human 206 5.55x55 TM5 I => S missense 0.0001751 14 79946 0 0.85 0.297
cltr1_human 199 5.48x48 TM5 I => V missense 3.761e-05 3 79772 0 0.25 0.074
cltr1_human 198 5.47x47 TM5 F => C missense 1.253e-05 1 79789 0 0.03 0.833 SodiumPocket MicroSwitch
cltr1_human 198 5.47x47 TM5 F => S missense 1.253e-05 1 79789 0 0.0 0.994 SodiumPocket MicroSwitch
cltr1_human 191 5.40x41 TM5 Y => F missense 1.242e-05 1 80537 0 0.15 0.651
cltr1_human 188 5.37x38 TM5 V => I missense 1.233e-05 1 81108 0 0.93 0.012
cltr1_human 184 5.33x34 TM5 N => Y missense 2.444e-05 2 81828 0 0.08 0.005
cltr1_human 176 ECL2 P => L missense 4.818e-05 4 83020 0 1.0 0.998
cltr1_human 165 ECL2 K => E missense 2.396e-05 2 83488 0 0.45 0.014
cltr1_human 163 ECL2 P => L missense 1.198e-05 1 83439 0 0.32 0.001
cltr1_human 163 ECL2 P => T missense 1.198e-05 1 83482 0 0.82 0.001
cltr1_human 161 4.63x64 TM4 A => T missense 2.397e-05 2 83423 0 0.41 0.001
cltr1_human 161 4.63x64 TM4 A => P missense 2.397e-05 2 83423 0 0.07 0.167
cltr1_human 160 4.62x63 TM4 M => I missense 3.591e-05 3 83551 0 0.15 0.026
cltr1_human 152 4.54x54 TM4 I => N missense 7.14e-05 6 84031 0 0.03 0.281
cltr1_human 152 4.54x54 TM4 I => F missense 7.139e-05 6 84040 0 0.03 0.532
cltr1_human 143 4.45x45 TM4 V => L missense 1.179e-05 1 84850 0 0.3 0.06
cltr1_human 135 34.57x57 ICL2 V => I missense 1.171e-05 1 85369 0 0.3 0.015 GP (contact)
cltr1_human 123 3.52x52 TM3 I => T missense 0.0007123 61 85642 0 0.0 0.143
cltr1_human 122 3.51x51 TM3 C => Y missense 1.168e-05 1 85638 0 0.64 0.048
cltr1_human 121 3.50x50 TM3 R => Q missense 4.673e-05 4 85593 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
cltr1_human 121 3.50x50 TM3 R => P missense 1.168e-05 1 85593 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
cltr1_human 121 3.50x50 TM3 R => W missense 1.168e-05 1 85602 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
cltr1_human 117 3.46x46 TM3 M => T missense 1.167e-05 1 85689 0 0.0 0.985
cltr1_human 113 3.42x42 TM3 F => L missense 1.168e-05 1 85651 0 0.07 0.576
cltr1_human 102 3.31x31 TM3 A => V missense 2.336e-05 2 85602 0 0.05 0.261
cltr1_human 101 3.30x30 TM3 Y => S missense 1.168e-05 1 85652 0 0.0 0.998
cltr1_human 97 3.26x26 TM3 R => H missense 8.18e-05 7 85571 0 0.0 1.0
cltr1_human 90 23.51x51 ECL1 L => V missense 1.164e-05 1 85890 0 0.52 0.005
cltr1_human 79 2.60x60 TM2 R => H missense 1.159e-05 1 86248 0 0.0 1.0
cltr1_human 79 2.60x60 TM2 R => L missense 1.159e-05 1 86248 0 0.0 1.0
cltr1_human 79 2.60x60 TM2 R => C missense 1.159e-05 1 86277 0 0.0 1.0
cltr1_human 74 2.55x55 TM2 C => S missense 2.308e-05 2 86646 0 0.65 0.159
cltr1_human 72 2.53x53 TM2 C => Y missense 1.154e-05 1 86686 0 0.45 0.898
cltr1_human 70 2.51x51 TM2 L => Q missense 1.152e-05 1 86774 0 0.0 0.964
cltr1_human 68 2.49x49 TM2 A => T missense 2.303e-05 2 86851 0 0.0 0.528
cltr1_human 61 2.42x42 TM2 Y => C missense 2.297e-05 2 87057 0 0.0 0.599
cltr1_human 60 2.41x41 TM2 V => I missense 1.148e-05 1 87085 0 0.63 0.045
cltr1_human 55 ICL1 K => Q missense 1.147e-05 1 87204 0 0.07 0.827
cltr1_human 47 1.56x56 TM1 V => F missense 1.146e-05 1 87261 0 0.0 0.883
cltr1_human 29 1.38x38 TM1 L => F missense 1.148e-05 1 87088 0 0.21 0.006
cltr1_human 23 1.32x32 TM1 N => S missense 1.154e-05 1 86628 0 0.19 0.186
cltr1_human 22 1.31x31 TM1 R => H missense 8.098e-05 7 86441 0 0.0 0.978
cltr1_human 22 1.31x31 TM1 R => C missense 1.157e-05 1 86435 0 0.0 0.99
cltr1_human 20 1.29x29 TM1 D => G missense 1.16e-05 1 86185 0 0.02 0.358
cltr1_human 17 1.26x26 TM1 T => I missense 1.166e-05 1 85787 0 0.01 0.066
cltr1_human 10 N-term S => P missense 3.555e-05 3 84390 0 0.21 0.001 PTM (Phosphorylation)
cltr1_human 8 N-term T => A missense 1.19e-05 1 84057 0 0.19 0.391 PTM (Phosphorylation)
cltr1_human 8 N-term T => P missense 1.19e-05 1 84057 0 0.03 0.112 PTM (Phosphorylation)


Residue

Diagrams

ICL1 Y H K K ICL1ECL1 G I W L F ECL1ICL2 P V Q N I N L V ICL2ECL2 K P Q K D E K N N T K C F E P P Q ECL2ICL3 K S M K K ICL3ECL3 E T K ECL3N-term M D E T G N L T V S N-termC-term H S L S S V T Y V P R K K A S L P E K G E E I C K V C-term S A T C H D T I D D F R N Q V Y S T L Y S M I S V V G F F G N G F V L Y V L I K T S A F Q V Y M I N L A V A D L L C V C T L P L R V V Y Y V H K G D F L C R L S T Y A L Y V N L Y C S I F F M T A M S F F R C I A I V F T Q K K A R F V C V G I W I F V I L T S S P F L M A D N Q T K N H V L V L H Y V S L F V G F I I P F V I I I V C Y T M I I L T L L K N L S S H K K A I G M I M V V T A A F L V S F M P Y H I Q R T I H L H F L H N P C D S V L R M Q K S V V I T L S L A A S N C C F D P L L Y F F S G G N L S T F R K R F R K
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