Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
cltr2_human 96 2.62x62 TM2 D => IlefsTer33 frameshift 1.649e-05 2 121320 0 None None
cltr2_human 135 3.49x49 TM3 V => CysfsTer37 frameshift 8.238e-06 1 121388 0 None None SodiumPocket MicroSwitch
cltr2_human 156 4.43x43 TM4 W => Ter stop gained 8.24e-06 1 121358 0 None None
cltr2_human 161 4.48x48 TM4 I => AspfsTer19 frameshift 4.944e-05 6 121348 0 None None
cltr2_human 203 5.40x41 TM5 Y => Ter stop gained 8.24e-06 1 121362 0 None None
cltr2_human 206 5.43x44 TM5 L => TrpfsTer18 frameshift 1.648e-05 2 121370 0 None None
cltr2_human 293 7.41x40 TM7 L => Ter stop gained 8.299e-06 1 120490 0 None None
cltr2_human 306 7.54x54 TM7 Y => Ter stop gained 1.708e-05 2 117104 0 None None
cltr2_human 11 N-term S => P missense 8.268e-06 1 120954 0 0.12 0.001
cltr2_human 14 N-term V => I missense 4.127e-05 5 121156 0 1.0 0.0
cltr2_human 17 N-term M => T missense 1.649e-05 2 121268 0 0.03 0.01
cltr2_human 19 N-term P => L missense 0.0001319 16 121294 0 0.43 0.001
cltr2_human 22 N-term T => N missense 8.243e-06 1 121316 0 0.57 0.004
cltr2_human 36 1.30x30 TM1 F => L missense 0.0001071 13 121344 0 0.0 0.998
cltr2_human 39 1.33x33 TM1 E => Q missense 0.002918 354 121336 5 0.72 0.005
cltr2_human 42 1.36x36 TM1 P => S missense 8.241e-06 1 121342 0 0.51 1.0
cltr2_human 42 1.36x36 TM1 P => L missense 8.241e-06 1 121338 0 0.0 1.0
cltr2_human 44 1.38x38 TM1 V => A missense 3.296e-05 4 121344 0 0.27 0.006
cltr2_human 46 1.40x40 TM1 L => P missense 8.241e-06 1 121348 0 0.02 0.994
cltr2_human 48 1.42x42 TM1 I => L missense 8.24e-06 1 121354 0 0.0 0.591
cltr2_human 50 1.44x44 TM1 F => V missense 0.004738 575 121352 4 1.0 0.0
cltr2_human 58 1.52x52 TM1 L => S missense 1.648e-05 2 121366 0 0.0 0.588
cltr2_human 61 1.55x55 TM1 Y => F missense 8.24e-06 1 121366 0 0.29 0.083
cltr2_human 65 1.59x59 TM1 Q => P missense 8.24e-06 1 121358 0 0.0 0.912
cltr2_human 66 1.60x60 TM1 P => S missense 6.592e-05 8 121352 0 0.61 0.054
cltr2_human 66 1.60x60 TM1 P => L missense 9.889e-05 12 121352 0 0.06 0.052
cltr2_human 67 ICL1 Y => H missense 7.417e-05 9 121348 0 0.14 0.026
cltr2_human 70 ICL1 S => F missense 8.241e-06 1 121348 0 0.01 0.83
cltr2_human 74 2.40x40 TM2 N => S missense 8.241e-06 1 121340 0 0.01 0.974
cltr2_human 75 2.41x41 TM2 V => I missense 8.242e-06 1 121336 0 0.79 0.012
cltr2_human 77 2.43x43 TM2 M => L missense 8.242e-06 1 121336 0 0.06 0.583
cltr2_human 79 2.45x45 TM2 N => S missense 8.242e-06 1 121328 0 0.0 1.0
cltr2_human 80 2.46x46 TM2 L => V missense 8.242e-06 1 121326 0 0.0 1.0
cltr2_human 90 2.56x56 TM2 T => M missense 0.0001566 19 121332 0 0.01 0.998
cltr2_human 92 2.58x58 TM2 P => R missense 8.242e-06 1 121326 0 0.0 1.0
cltr2_human 95 2.61x61 TM2 A => T missense 8.243e-06 1 121320 0 0.03 0.828
cltr2_human 95 2.61x61 TM2 A => V missense 8.243e-06 1 121318 0 1.0 0.058
cltr2_human 97 2.63x63 TM2 Y => N missense 8.243e-05 10 121322 0 0.0 1.0
cltr2_human 100 2.66x66 TM2 R => I missense 8.242e-06 1 121334 0 0.09 0.438
cltr2_human 101 2.67x67 TM2 G => V missense 8.243e-06 1 121314 0 0.01 0.954
cltr2_human 103 23.49x49 ECL1 N => D missense 8.243e-06 1 121320 0 0.45 0.009
cltr2_human 103 23.49x49 ECL1 N => S missense 0.005053 613 121322 5 0.27 0.048
cltr2_human 103 23.49x49 ECL1 N => T missense 8.243e-06 1 121322 0 0.17 0.243
cltr2_human 108 3.22x22 TM3 D => H missense 8.242e-06 1 121326 0 0.0 0.923
cltr2_human 109 3.23x23 TM3 L => P missense 2.473e-05 3 121334 0 0.01 0.882
cltr2_human 114 3.28x28 TM3 M => I missense 3.296e-05 4 121348 0 0.68 0.207
cltr2_human 116 3.30x30 TM3 Y => H missense 8.24e-06 1 121356 0 0.0 0.993
cltr2_human 117 3.31x31 TM3 S => P missense 8.24e-06 1 121356 0 0.01 0.989
cltr2_human 118 3.32x32 TM3 L => F missense 8.24e-06 1 121362 0 0.14 0.01
cltr2_human 119 3.33x33 TM3 Y => H missense 8.24e-06 1 121362 0 0.02 0.712 LB (polar (hydrogen bond))
cltr2_human 122 3.36x36 TM3 M => T missense 3.296e-05 4 121376 0 0.0 0.999
cltr2_human 123 3.37x37 TM3 Y => H missense 4.119e-05 5 121380 0 0.0 0.995 LB (hydrophobic, Van der Waals, aromatic (face-to-edge))
cltr2_human 124 3.38x38 TM3 S => G missense 1.648e-05 2 121380 0 0.03 0.034
cltr2_human 128 3.42x42 TM3 F => L missense 2.471e-05 3 121390 0 0.04 1.0
cltr2_human 131 3.45x45 TM3 V => M missense 6.59e-05 8 121390 0 0.04 0.972
cltr2_human 132 3.46x46 TM3 L => R missense 2.471e-05 3 121388 0 0.0 0.998
cltr2_human 136 3.50x50 TM3 R => C missense 1.648e-05 2 121392 0 0.02 0.998 SodiumPocket MicroSwitch GP (contact)
cltr2_human 136 3.50x50 TM3 R => H missense 1.648e-05 2 121386 0 0.01 0.696 SodiumPocket MicroSwitch GP (contact)
cltr2_human 136 3.50x50 TM3 R => P missense 8.238e-06 1 121386 0 0.0 0.998 SodiumPocket MicroSwitch GP (contact)
cltr2_human 137 3.51x51 TM3 F => S missense 0.0002389 29 121390 0 0.0 0.971
cltr2_human 139 3.53x53 TM3 A => S missense 8.238e-06 1 121388 0 0.0 1.0 GP (contact)
cltr2_human 139 3.53x53 TM3 A => V missense 8.238e-06 1 121386 0 0.02 1.0 GP (contact)
cltr2_human 140 3.54x54 TM3 M => V missense 1.648e-05 2 121386 0 0.05 0.0 GP (contact)
cltr2_human 140 3.54x54 TM3 M => T missense 1.648e-05 2 121384 0 0.49 0.0 GP (contact)
cltr2_human 145 34.52x52 ICL2 R => W missense 6.591e-05 8 121374 0 0.03 0.959 GP (contact)
cltr2_human 145 34.52x52 ICL2 R => Q missense 0.0001977 24 121378 0 0.91 0.098 GP (contact)
cltr2_human 146 34.53x53 ICL2 L => F missense 8.239e-06 1 121372 0 0.7 0.009 GP (contact)
cltr2_human 153 4.40x40 TM4 R => K missense 8.24e-06 1 121358 0 1.0 0.014
cltr2_human 154 4.41x41 TM4 S => N missense 0.001599 194 121360 0 0.64 0.003
cltr2_human 161 4.48x48 TM4 I => F missense 8.241e-06 1 121344 0 0.3 0.009
cltr2_human 166 4.53x53 TM4 I => F missense 8.241e-06 1 121340 0 0.0 0.529 LB (hydrophobic, Van der Waals)
cltr2_human 166 4.53x53 TM4 I => T missense 5.769e-05 7 121344 0 0.03 0.024 LB (hydrophobic, Van der Waals)
cltr2_human 168 4.55x55 TM4 A => P missense 8.242e-06 1 121332 0 0.09 0.966
cltr2_human 171 4.58x59 TM4 I => V missense 8.241e-06 1 121338 0 0.25 0.002
cltr2_human 171 4.58x59 TM4 I => T missense 8.241e-06 1 121338 0 0.56 0.002
cltr2_human 172 4.59x60 TM4 M => K missense 8.242e-06 1 121336 0 0.19 0.08
cltr2_human 174 4.61x62 TM4 L => R missense 2.472e-05 3 121338 0 0.0 0.999
cltr2_human 176 4.63x64 TM4 S => T missense 1.648e-05 2 121342 0 0.5 0.007
cltr2_human 177 ECL2 G => S missense 8.241e-06 1 121340 0 0.06 0.639
cltr2_human 201 5.38x39 TM5 M => V missense 0.01701 2064 121362 28 0.05 0.345 LB (hydrophobic, Van der Waals)
cltr2_human 202 5.39x40 TM5 N => K missense 8.24e-06 1 121358 0 0.0 1.0 LB (Van der Waals)
cltr2_human 203 5.40x41 TM5 Y => C missense 2.472e-05 3 121360 0 0.02 0.937
cltr2_human 205 5.42x43 TM5 A => T missense 8.239e-06 1 121370 0 0.06 0.309 LB (hydrophobic, Van der Waals)
cltr2_human 209 5.46x461 TM5 G => D missense 8.24e-06 1 121366 0 0.0 1.0 LB (Van der Waals)
cltr2_human 210 5.47x47 TM5 C => W missense 2.472e-05 3 121376 0 0.0 0.001 SodiumPocket MicroSwitch
cltr2_human 211 5.48x48 TM5 L => Q missense 2.472e-05 3 121378 0 0.0 0.83
cltr2_human 216 5.53x53 TM5 T => I missense 8.238e-06 1 121382 0 0.52 0.024
cltr2_human 218 5.55x55 TM5 S => R missense 2.472e-05 3 121378 0 0.11 0.721
cltr2_human 220 5.57x57 TM5 C => Y missense 0.0001895 23 121370 0 0.0 0.995
cltr2_human 225 5.62x62 TM5 I => V missense 8.24e-06 1 121352 0 0.17 0.21
cltr2_human 225 5.62x62 TM5 I => N missense 8.241e-06 1 121348 0 0.0 0.983
cltr2_human 226 5.63x63 TM5 R => W missense 2.472e-05 3 121342 0 0.05 0.998
cltr2_human 226 5.63x63 TM5 R => Q missense 8.242e-06 1 121332 0 0.02 0.962
cltr2_human 227 5.64x64 TM5 V => F missense 8.241e-06 1 121340 0 0.0 0.328 GP (contact)
cltr2_human 227 5.64x64 TM5 V => D missense 8.241e-06 1 121338 0 0.01 0.291 GP (contact)
cltr2_human 232 ICL3 E => Q missense 3.297e-05 4 121310 0 0.27 0.529
cltr2_human 236 6.24x25 TM6 S => L missense 0.009391 1139 121280 57 0.23 0.01 GP (contact)
cltr2_human 239 6.27x28 TM6 R => W missense 3.299e-05 4 121254 0 0.0 0.804 GP (contact)
cltr2_human 239 6.27x28 TM6 R => Q missense 8.247e-05 10 121258 0 0.43 0.016 GP (contact)
cltr2_human 242 6.30x31 TM6 H => Q missense 0.003051 370 121272 8 0.06 0.281
cltr2_human 249 6.37x38 TM6 I => V missense 9.895e-05 12 121270 0 0.12 0.016
cltr2_human 251 6.39x40 TM6 I => V missense 0.0002886 35 121274 1 0.16 0.759 GP (contact)
cltr2_human 253 6.41x42 TM6 L => S missense 8.245e-06 1 121280 0 0.0 0.971
cltr2_human 259 6.47x47 TM6 C => G missense 4.122e-05 5 121304 0 0.01 1.0
cltr2_human 263 6.51x51 TM6 Y => C missense 0.0002885 35 121328 0 0.0 1.0
cltr2_human 264 6.52x52 TM6 H => R missense 8.242e-06 1 121326 0 0.0 1.0
cltr2_human 268 6.56x56 TM6 T => A missense 8.242e-06 1 121332 0 0.01 1.0
cltr2_human 269 6.57x57 TM6 V => I missense 4.944e-05 6 121348 0 0.59 0.001
cltr2_human 272 6.60x60 TM6 T => M missense 0.0001401 17 121348 0 0.11 0.0
cltr2_human 278 ECL3 L => I missense 0.00473 574 121356 4 0.22 0.0
cltr2_human 281 7.29x28 TM7 D => E missense 0.0005605 68 121328 3 1.0 0.003
cltr2_human 282 7.30x29 TM7 R => G missense 2.473e-05 3 121326 0 0.41 0.001
cltr2_human 288 7.36x35 TM7 V => I missense 1.652e-05 2 121096 0 0.08 0.2
cltr2_human 292 7.40x39 TM7 A => G missense 0.0001575 19 120610 0 0.04 0.226
cltr2_human 295 7.43x42 TM7 A => V missense 1.665e-05 2 120086 0 0.05 0.21
cltr2_human 298 7.46x46 TM7 A => T missense 8.36e-06 1 119620 0 0.29 0.0
cltr2_human 299 7.47x47 TM7 C => F missense 0.0004358 52 119330 0 0.0 1.0
cltr2_human 299 7.47x47 TM7 C => Y missense 8.38e-06 1 119330 0 0.0 1.0
cltr2_human 308 7.56x56 TM7 A => V missense 1.715e-05 2 116642 0 0.09 0.059 GP (contact)
cltr2_human 311 8.49x49 H8 N => K missense 8.635e-05 10 115802 0 0.0 1.0 GP (contact)
cltr2_human 315 8.53x53 H8 R => K missense 0.002308 265 114804 2 0.18 0.036
cltr2_human 333 C-term V => F missense 9.067e-06 1 110290 0 nan 0.001
cltr2_human 337 C-term S => N missense 9.104e-06 1 109844 0 nan 0.197
cltr2_human 342 C-term K => N missense 9.161e-06 1 109154 0 nan 0.002
cltr2_human 346 C-term V => A missense 9.262e-06 1 107972 0 nan 0.131


Residue

Diagrams

ICL1 Y K K S ICL1ECL1 S N W I F ECL1ICL2 P F R L L H V T ICL2ECL2 G S E Q N G S V T S C L E L N L Y K ECL2ICL3 E V P E ICL3ECL3 K V G L C ECL3N-term M E R K F M S L Q P S I S V S E M E P N G T F S N N N S R N N-termC-term G H P Q K A K T K C V F P V S V W L R K E T R V C-term C T I E N F K R E F F P I V Y L I I F F W G V L G N G L S I Y V F L Q P T S V N V F M L N L A I S D L L F I S T L P F R A D Y Y L R G G D L A C R I M S Y S L Y V N M Y S S I Y F L T V L S V V R F L A M V H S I R S A W I L C G I I W I L I M A S S I M L L D S I A K L Q T M N Y I A L V V G C L L P F F T L S I C Y L L I I R V L L K V S G L R V S H R K A L T T I I I T L I I F F L C F L P Y H T L R T V H L T T W K D R L H K A L V I T L A L A A A N A C F N P L L Y Y F A G E N L K S F K D R A L R K
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