Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
drd2_human 272 ICL3 A => Ter stop gained 3.569e-05 4 112082 0 None None
drd2_human 443 C-term C => F missense 8.238e-06 1 121396 0 0.0 1.0
drd2_human 442 8.59x59 H8 H => Y missense 8.238e-05 10 121394 0 0.13 0.998
drd2_human 431 8.48x48 H8 I => T missense 5.766e-05 7 121406 0 0.25 0.067 GP (contact)
drd2_human 410 7.37x36 TM7 A => T missense 0.001046 127 121392 1 0.04 0.219 LB (hydrophobic, Van der Waals)
drd2_human 410 7.37x36 TM7 A => S missense 8.238e-06 1 121392 0 0.0 0.714 LB (hydrophobic, Van der Waals)
drd2_human 404 7.31x30 TM7 P => R missense 8.241e-06 1 121346 0 0.0 0.975
drd2_human 399 6.61x61 TM6 C => R missense 8.252e-06 1 121180 0 0.0 0.999
drd2_human 389 6.51x51 TM6 F => V missense 8.343e-06 1 119862 0 0.0 1.0 LB (hydrophobic, Van der Waals, polar (hydrogen bond), aromatic (edge-to-face))
drd2_human 381 6.43x43 TM6 V => M missense 3.401e-05 4 117612 0 0.0 0.917
drd2_human 377 6.39x39 TM6 I => T missense 8.25e-06 1 121214 0 0.0 0.996
drd2_human 376 6.38x38 TM6 A => T missense 8.246e-06 1 121278 0 0.02 0.997
drd2_human 366 6.28x28 TM6 Q => K missense 8.238e-06 1 121384 0 0.87 0.779 GP (contact)
drd2_human 360 ICL3 R => H missense 0.000173 21 121404 0 0.02 0.927
drd2_human 360 ICL3 R => C missense 8.237e-06 1 121404 0 0.0 0.949
drd2_human 356 ICL3 K => R missense 8.237e-06 1 121404 0 0.21 0.938
drd2_human 354 ICL3 S => C missense 8.237e-06 1 121408 0 0.0 0.839 PTM (Phosphorylation)
drd2_human 352 ICL3 R => Q missense 2.471e-05 3 121406 0 0.38 0.052
drd2_human 352 ICL3 R => W missense 3.295e-05 4 121406 0 0.06 0.921
drd2_human 348 ICL3 N => S missense 3.295e-05 4 121408 0 0.03 0.487
drd2_human 340 ICL3 I => T missense 8.237e-06 1 121404 0 0.42 0.003
drd2_human 334 ICL3 H => Q missense 8.237e-06 1 121410 0 0.49 0.137
drd2_human 331 ICL3 A => V missense 8.237e-06 1 121408 0 0.14 0.373
drd2_human 329 ICL3 G => R missense 8.237e-06 1 121402 0 0.2 0.997
drd2_human 327 ICL3 K => E missense 0.003814 463 121404 4 0.43 0.281
drd2_human 323 ICL3 A => T missense 1.648e-05 2 121392 0 0.56 0.005
drd2_human 314 ICL3 G => D missense 8.24e-06 1 121366 0 0.53 0.148
drd2_human 314 ICL3 G => S missense 1.648e-05 2 121368 0 0.8 0.004
drd2_human 311 ICL3 S => C missense 0.02641 3202 121226 73 0.03 0.999
drd2_human 310 ICL3 P => L missense 3.3e-05 4 121218 0 0.28 0.016
drd2_human 310 ICL3 P => S missense 0.001369 166 121220 2 0.74 0.004
drd2_human 309 ICL3 D => N missense 0.0001155 14 121192 0 0.48 0.002
drd2_human 300 ICL3 P => H missense 8.271e-06 1 120900 0 0.06 0.853
drd2_human 294 ICL3 R => Q missense 8.333e-06 1 120008 0 0.42 0.075
drd2_human 294 ICL3 R => W missense 8.332e-06 1 120024 0 0.01 0.849
drd2_human 291 ICL3 E => A missense 8.34e-06 1 119910 0 0.1 0.775
drd2_human 291 ICL3 E => K missense 2.503e-05 3 119844 0 0.37 0.786
drd2_human 288 ICL3 S => T missense 8.366e-06 1 119532 0 0.43 0.105
drd2_human 287 ICL3 T => I missense 8.374e-06 1 119424 0 0.26 0.595
drd2_human 282 ICL3 E => D missense 1.692e-05 2 118174 0 0.45 0.021
drd2_human 279 ICL3 L => Q missense 8.585e-06 1 116488 0 0.19 0.622
drd2_human 276 ICL3 A => T missense 8.887e-06 1 112520 0 0.28 0.117
drd2_human 275 ICL3 R => Q missense 8.998e-06 1 111130 0 0.55 0.028
drd2_human 274 ICL3 R => Q missense 2.733e-05 3 109766 0 0.59 0.309
drd2_human 269 ICL3 R => K missense 8.236e-06 1 121412 0 1.0 0.001
drd2_human 268 ICL3 R => Q missense 2.471e-05 3 121412 0 0.28 0.396
drd2_human 268 ICL3 R => W missense 1.647e-05 2 121412 0 0.01 0.95
drd2_human 256 ICL3 I => V missense 8.236e-06 1 121412 0 0.38 0.275
drd2_human 255 ICL3 V => I missense 8.236e-06 1 121412 0 0.47 0.39
drd2_human 250 ICL3 M => V missense 1.647e-05 2 121412 0 1.0 0.001
drd2_human 246 ICL3 H => Y missense 8.236e-06 1 121412 0 0.0 0.995
drd2_human 234 ICL3 A => T missense 8.326e-06 1 120110 0 0.45 0.008
drd2_human 230 ICL3 R => Q missense 8.282e-06 1 120746 0 1.0 0.015
drd2_human 227 ICL3 R => H missense 1.651e-05 2 121114 0 0.03 0.982
drd2_human 227 ICL3 R => G missense 7.427e-05 9 121178 0 0.02 0.969
drd2_human 227 ICL3 R => C missense 8.252e-06 1 121178 0 0.0 0.982
drd2_human 226 5.75x75 TM5 K => R missense 8.25e-06 1 121212 0 0.8 0.117 GP (contact)
drd2_human 223 5.72x72 TM5 V => I missense 3.298e-05 4 121290 0 0.92 0.995 GP (contact)
drd2_human 222 5.71x71 TM5 R => Q missense 8.244e-06 1 121304 0 0.0 1.0 GP (contact)
drd2_human 220 5.69x69 TM5 R => H missense 2.472e-05 3 121350 0 0.0 0.999 GP (contact)
drd2_human 220 5.69x69 TM5 R => C missense 8.239e-06 1 121370 0 0.0 0.999 GP (contact)
drd2_human 210 5.59x59 TM5 I => V missense 8.237e-06 1 121406 0 1.0 0.004
drd2_human 200 5.49x49 TM5 V => M missense 9.891e-05 12 121328 0 0.02 0.943
drd2_human 177 ECL2 A => T missense 2.673e-05 3 112252 0 nan 0.002
drd2_human 176 ECL2 N => D missense 8.807e-06 1 113550 0 0.03 0.533
drd2_human 175 ECL2 N => S missense 8.765e-06 1 114088 0 0.01 0.58
drd2_human 175 ECL2 N => D missense 8.749e-06 1 114296 0 0.0 0.933
drd2_human 173 4.63x64 TM4 G => R missense 2.602e-05 3 115296 0 0.0 1.0
drd2_human 158 4.48x48 TM4 I => V missense 8.42e-06 1 118762 0 1.0 0.004
drd2_human 154 4.44x44 TM4 V => I missense 5.9e-05 7 118644 0 0.09 0.733
drd2_human 150 4.40x40 TM4 R => H missense 4.222e-05 5 118420 0 0.0 0.999
drd2_human 150 4.40x40 TM4 R => C missense 1.689e-05 2 118414 0 0.0 0.999
drd2_human 145 4.35x35 TM4 R => H missense 1.693e-05 2 118100 0 0.04 1.0
drd2_human 145 4.35x35 TM4 R => S missense 3.386e-05 4 118142 0 0.03 1.0
drd2_human 145 4.35x35 TM4 R => C missense 8.464e-06 1 118142 0 0.0 1.0
drd2_human 140 34.51x51 ICL2 M => V missense 8.517e-06 1 117408 0 0.6 0.986 GP (contact)
drd2_human 138 3.56x56 TM3 M => V missense 8.559e-06 1 116832 0 0.0 0.997 GP (contact)
drd2_human 134 3.52x52 TM3 T => I missense 8.633e-06 1 115840 0 0.14 0.999 PTM (Phosphorylation)
drd2_human 131 3.49x49 TM3 D => N missense 1.659e-05 2 120576 0 0.0 0.871 SodiumPocket MicroSwitch
drd2_human 128 3.46x46 TM3 I => V missense 8.265e-06 1 120988 0 0.0 0.785
drd2_human 126 3.44x44 TM3 C => W missense 8.262e-06 1 121038 0 0.0 1.0
drd2_human 111 3.29x29 TM3 V => I missense 1.649e-05 2 121276 0 0.01 0.044 LB (hydrophobic)
drd2_human 99 23.49x49 ECL1 E => K missense 8.262e-06 1 121036 0 0.2 0.098
drd2_human 96 2.66x65 TM2 V => A missense 1.656e-05 2 120746 0 0.0 0.933
drd2_human 91 2.61x60 TM2 V => I missense 8.451e-06 1 118330 0 0.01 0.769 LB (hydrophobic, polar (hydrogen bond))
drd2_human 77 2.47x47 TM2 A => T missense 8.26e-06 1 121066 0 0.0 1.0
drd2_human 67 2.37x37 TM2 T => S missense 4.945e-05 6 121332 0 0.01 0.997
drd2_human 64 12.49x49 ICL1 A => V missense 0.0001236 15 121360 0 0.01 0.954
drd2_human 61 1.59x59 TM1 R => H missense 8.238e-06 1 121384 0 0.0 1.0
drd2_human 57 1.55x55 TM1 M => V missense 8.238e-06 1 121396 0 0.15 0.099
drd2_human 49 1.47x47 TM1 V => I missense 1.647e-05 2 121406 0 0.19 0.999
drd2_human 46 1.44x44 TM1 A => T missense 8.237e-06 1 121410 0 0.0 0.031
drd2_human 43 1.41x41 TM1 L => P missense 8.237e-06 1 121410 0 0.0 1.0
drd2_human 38 1.36x36 TM1 A => V missense 8.237e-06 1 121410 0 0.0 0.999
drd2_human 37 1.35x35 TM1 Y => C missense 1.647e-05 2 121410 0 0.0 1.0
drd2_human 29 N-term A => V missense 4.118e-05 5 121410 0 0.28 0.016
drd2_human 29 N-term A => P missense 8.237e-06 1 121410 0 0.31 0.043
drd2_human 28 N-term K => R missense 8.237e-06 1 121410 0 0.34 0.347
drd2_human 27 N-term G => R missense 1.647e-05 2 121404 0 0.26 0.075
drd2_human 26 N-term D => E missense 8.237e-06 1 121408 0 1.0 0.001
drd2_human 24 N-term G => R missense 2.471e-05 3 121408 0 0.03 0.817
drd2_human 20 N-term R => Q missense 8.237e-06 1 121410 0 nan 0.01
drd2_human 20 N-term R => P missense 2.471e-05 3 121410 0 nan 0.563
drd2_human 20 N-term R => W missense 3.295e-05 4 121408 0 nan 0.785
drd2_human 16 N-term Q => H missense 8.237e-06 1 121410 0 nan 0.002
drd2_human 10 N-term D => H missense 1.647e-05 2 121400 0 0.01 0.531
drd2_human 4 N-term L => R missense 7.414e-05 9 121394 0 nan 0.046


Residue

Diagrams

ICL1 K A L Q ICL1ECL1 E W K F ECL1ICL2 P M L Y N ICL2ECL2 L N N A D Q N E C I I A ECL2ICL3 R S S R A F R A H L R A P L K G N C T H P E D M K L C T V I M K S N G S F P V N R R R V E A A R R A Q E L E M E M L S S T S P P E R T R Y S P I P P S H H Q L T L P D P S H H G L H S T P D S P A K P E K N G H A K D H P K I A K I F E I Q T M P N G K T R T S L K T M S R R ICL3ECL3 D C N I ECL3N-term M D P L N L S W Y D D D L E R Q N W S R P F N G S D G K A D N-termC-term C C-term R P H Y N Y Y A T L L T L L I A V I V F G N V L V C M A V S R E T T T N Y L I V S L A V A D L L V A T L V M P W V V Y L E V V G S R I H C D I F V T L D V M M C T A S I L N L C A I S I D R Y T A V A M T R Y S S K R R V T V M I S I V W V L S F T I S C P L L F G N P A F V V Y S S I V S F Y V P F I V T L L V Y I K I Y I V L R R R R K R V N T K K L S Q Q K E K K A T Q M L A I V L G V F I I C W L P F F I T H I L N I H C P P V L Y S A F T W L G Y V N S A V N P I I Y T T F N I E F L K F R K A I L H
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