Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
mtr1a_human 291 7.49x49 TM7 N => MetfsTer8 frameshift 8.237e-06 1 121410 0 None None SodiumPocket MicroSwitch
mtr1a_human 229 6.26x26 TM6 L => GlnfsTer35 frameshift 8.251e-06 1 121204 0 None None GP (contact)
mtr1a_human 170 ECL2 Y => Ter stop gained 2.471e-05 3 121394 0 None None
mtr1a_human 120 3.45x45 TM3 G => ArgfsTer105 frameshift 8.239e-06 1 121376 0 None None
mtr1a_human 105 3.30x30 TM3 F => SerfsTer2 frameshift 8.237e-06 1 121404 0 None None
mtr1a_human 93 23.50x50 ECL1 W => Ter stop gained 3.295e-05 4 121398 0 None None
mtr1a_human 57 12.49x49 ICL1 K => Ter stop gained 2.454e-05 1 40756 0 None None
mtr1a_human 350 C-term V => I missense 1.647e-05 2 121404 0 nan 0.052
mtr1a_human 348 C-term D => N missense 0.001516 184 121408 1 nan 0.021
mtr1a_human 348 C-term D => Y missense 8.237e-06 1 121408 0 nan 0.651
mtr1a_human 346 C-term K => R missense 1.647e-05 2 121410 0 nan 0.005
mtr1a_human 345 C-term V => I missense 0.0002553 31 121410 0 nan 0.003
mtr1a_human 340 C-term T => I missense 1.647e-05 2 121410 0 0.08 0.005
mtr1a_human 337 C-term P => L missense 1.647e-05 2 121408 0 0.0 0.847
mtr1a_human 335 C-term P => L missense 1.647e-05 2 121406 0 0.03 0.046
mtr1a_human 335 C-term P => Q missense 8.237e-06 1 121406 0 0.04 0.099
mtr1a_human 334 C-term K => N missense 0.002109 256 121408 1 0.02 0.072
mtr1a_human 331 C-term V => F missense 0.0005271 64 121410 0 0.38 0.058
mtr1a_human 329 C-term D => H missense 8.237e-06 1 121410 0 0.03 0.006
mtr1a_human 329 C-term D => N missense 1.647e-05 2 121410 0 0.04 0.006
mtr1a_human 327 C-term V => M missense 8.237e-06 1 121410 0 0.22 0.007
mtr1a_human 326 C-term D => N missense 8.237e-05 10 121410 0 0.26 0.002
mtr1a_human 323 C-term S => G missense 8.236e-06 1 121412 0 0.1 0.003
mtr1a_human 321 C-term V => M missense 3.295e-05 4 121412 0 0.27 0.007
mtr1a_human 318 C-term V => L missense 8.236e-06 1 121412 0 1.0 0.001
mtr1a_human 317 C-term R => S missense 8.236e-06 1 121412 0 0.1 0.028
mtr1a_human 316 C-term A => T missense 4.118e-05 5 121412 0 0.09 0.001
mtr1a_human 315 8.63x63 H8 T => A missense 8.236e-06 1 121412 0 0.46 0.002
mtr1a_human 310 8.58x58 H8 I => T missense 2.471e-05 3 121412 0 0.0 0.288
mtr1a_human 309 8.57x57 H8 I => T missense 2.471e-05 3 121410 0 0.0 0.441
mtr1a_human 307 8.55x55 H8 R => K missense 1.647e-05 2 121410 0 1.0 0.002
mtr1a_human 298 7.56x56 TM7 L => R missense 8.237e-06 1 121410 0 0.0 0.49 GP (contact)
mtr1a_human 294 7.52x52 TM7 I => M missense 8.237e-06 1 121410 0 0.0 0.961
mtr1a_human 294 7.52x52 TM7 I => T missense 8.237e-06 1 121410 0 0.0 0.903
mtr1a_human 293 7.51x51 TM7 I => V missense 3.295e-05 4 121410 0 0.78 0.032
mtr1a_human 291 7.49x49 TM7 N => S missense 3.295e-05 4 121408 0 0.01 0.998 SodiumPocket MicroSwitch
mtr1a_human 285 7.43x42 TM7 Y => H missense 8.237e-06 1 121410 0 0.02 0.997 LB (hydrophobic, Van der Waals)
mtr1a_human 284 7.42x41 TM7 A => V missense 0.0002471 30 121400 0 0.04 0.446 LB (Van der Waals, hydrophobic)
mtr1a_human 283 7.41x40 TM7 M => V missense 8.237e-06 1 121398 0 0.05 0.063
mtr1a_human 281 7.39x38 TM7 Y => C missense 8.238e-06 1 121394 0 0.0 0.976 LB (hydrophobic, Van der Waals)
mtr1a_human 277 7.35x34 TM7 F => L missense 8.242e-06 1 121326 0 0.0 0.688
mtr1a_human 271 ECL3 R => G missense 8.243e-06 1 121320 0 0.03 0.219
mtr1a_human 266 ECL3 A => V missense 0.01994 2418 121254 28 0.2 0.002
mtr1a_human 266 ECL3 A => T missense 0.002078 252 121242 6 0.4 0.005
mtr1a_human 265 ECL3 P => A missense 8.248e-06 1 121236 0 0.0 0.224
mtr1a_human 261 6.58x58 TM6 V => M missense 8.253e-06 1 121162 0 0.02 0.96
mtr1a_human 258 6.55x55 TM6 G => D missense 8.255e-06 1 121138 0 0.0 0.241 LB (Van der Waals)
mtr1a_human 257 6.54x54 TM6 I => F missense 1.651e-05 2 121136 0 0.0 0.899
mtr1a_human 253 6.50x50 TM6 P => L missense 8.258e-06 1 121094 0 0.06 0.993 SodiumPocket MicroSwitch
mtr1a_human 249 6.46x46 TM6 I => M missense 8.259e-06 1 121082 0 0.04 0.751
mtr1a_human 249 6.46x46 TM6 I => F missense 8.259e-05 10 121082 1 0.16 0.072
mtr1a_human 241 6.38x38 TM6 F => V missense 1.652e-05 2 121082 0 0.03 0.841
mtr1a_human 234 6.31x31 TM6 F => L missense 2.477e-05 3 121112 0 0.37 0.002
mtr1a_human 233 6.30x30 TM6 D => V missense 8.255e-06 1 121142 0 0.04 0.733 SodiumPocket MicroSwitch
mtr1a_human 232 6.29x29 TM6 Q => P missense 8.253e-06 1 121162 0 0.06 0.158 GP (contact)
mtr1a_human 229 6.26x26 TM6 L => P missense 8.251e-06 1 121198 0 0.15 0.021 GP (contact)
mtr1a_human 225 ICL3 R => H missense 8.249e-06 1 121230 0 0.14 0.033
mtr1a_human 225 ICL3 R => L missense 8.249e-06 1 121230 0 0.27 0.009
mtr1a_human 225 ICL3 R => C missense 8.247e-06 1 121252 0 0.21 0.022
mtr1a_human 222 ICL3 K => N missense 8.247e-06 1 121256 0 0.03 0.309
mtr1a_human 221 5.72x72 TM5 V => E missense 8.247e-06 1 121252 0 0.0 0.839 GP (contact)
mtr1a_human 212 5.63x63 TM5 I => T missense 0.006042 733 121310 18 0.18 0.014
mtr1a_human 198 5.49x49 TM5 V => I missense 1.648e-05 2 121358 0 0.13 0.006
mtr1a_human 194 5.45x46 TM5 F => L missense 8.239e-06 1 121376 0 0.07 0.015
mtr1a_human 191 5.42x43 TM5 V => M missense 2.472e-05 3 121354 0 0.02 0.228 LB (hydrophobic, Van der Waals)
mtr1a_human 190 5.41x42 TM5 A => T missense 8.241e-06 1 121342 0 0.56 0.014
mtr1a_human 189 5.40x41 TM5 I => M missense 8.239e-06 1 121376 0 0.06 0.44
mtr1a_human 186 5.37x38 TM5 A => S missense 8.241e-06 1 121342 0 0.49 0.016
mtr1a_human 185 5.36x37 TM5 S => P missense 8.239e-06 1 121376 0 0.28 0.078
mtr1a_human 183 ECL2 V => I missense 3.296e-05 4 121368 0 0.2 0.022
mtr1a_human 180 ECL2 A => T missense 8.239e-06 1 121380 0 0.86 0.002
mtr1a_human 172 ECL2 P => L missense 1.648e-05 2 121392 0 0.0 0.943
mtr1a_human 170 ECL2 Y => F missense 8.238e-06 1 121392 0 0.01 0.277
mtr1a_human 166 4.64x65 TM4 G => E missense 0.00945 1147 121378 12 0.14 0.031
mtr1a_human 164 4.62x63 TM4 R => H missense 4.12e-05 5 121372 0 0.06 0.001
mtr1a_human 164 4.62x63 TM4 R => C missense 1.648e-05 2 121380 0 0.04 0.0
mtr1a_human 163 4.61x62 TM4 L => F missense 9.062e-05 11 121380 0 1.0 0.019 LB (hydrophobic)
mtr1a_human 162 4.60x61 TM4 N => K missense 8.239e-06 1 121374 0 0.0 0.937 LB (polar (hydrogen bond), Van der Waals)
mtr1a_human 162 4.60x61 TM4 N => H missense 8.242e-06 1 121324 0 0.0 0.984 LB (polar (hydrogen bond), Van der Waals)
mtr1a_human 161 4.59x60 TM4 P => A missense 8.24e-06 1 121352 0 0.01 0.957
mtr1a_human 159 4.57x57 TM4 V => I missense 1.65e-05 2 121236 0 1.0 0.002 LB (hydrophobic)
mtr1a_human 157 4.55x55 TM4 A => V missense 0.001838 223 121356 1 1.0 0.001
mtr1a_human 155 4.53x53 TM4 T => M missense 1.648e-05 2 121376 0 0.0 0.815
mtr1a_human 148 4.46x46 TM4 V => M missense 8.239e-06 1 121380 0 0.03 0.531
mtr1a_human 138 34.56x56 ICL2 L => P missense 8.238e-06 1 121382 0 0.0 0.948 GP (contact)
mtr1a_human 138 34.56x56 ICL2 L => V missense 8.238e-06 1 121386 0 0.21 0.113 GP (contact)
mtr1a_human 137 34.55x55 ICL2 K => N missense 8.238e-06 1 121384 0 0.0 0.616 GP (contact)
mtr1a_human 136 34.54x54 ICL2 D => N missense 1.648e-05 2 121380 1 0.09 0.056 GP (contact)
mtr1a_human 136 34.54x54 ICL2 D => H missense 8.239e-06 1 121380 0 0.48 0.041 GP (contact)
mtr1a_human 133 34.51x51 ICL2 L => R missense 8.239e-06 1 121372 0 0.01 0.217 GP (contact)
mtr1a_human 131 3.56x56 TM3 H => R missense 1.648e-05 2 121370 0 0.03 0.163 GP (contact)
mtr1a_human 129 3.54x54 TM3 I => V missense 8.239e-06 1 121368 0 0.1 0.58 GP (contact)
mtr1a_human 128 3.53x53 TM3 Y => C missense 8.239e-06 1 121368 0 0.1 0.013 GP (contact)
mtr1a_human 125 3.50x50 TM3 R => L missense 8.24e-06 1 121352 0 0.0 0.997 SodiumPocket MicroSwitch GP (contact)
mtr1a_human 124 3.49x49 TM3 N => K missense 8.239e-06 1 121368 0 0.0 0.993 SodiumPocket MicroSwitch
mtr1a_human 122 3.47x47 TM3 A => T missense 3.295e-05 4 121380 0 0.01 0.969
mtr1a_human 120 3.45x45 TM3 G => S missense 4.119e-05 5 121376 0 0.07 0.42
mtr1a_human 116 3.41x41 TM3 F => S missense 8.238e-06 1 121396 0 0.02 0.993
mtr1a_human 113 3.38x38 TM3 G => S missense 6.59e-05 8 121402 0 0.08 0.109
mtr1a_human 111 3.36x36 TM3 V => I missense 8.237e-06 1 121406 0 0.04 0.603 LB (hydrophobic)
mtr1a_human 110 3.35x35 TM3 S => R missense 8.237e-06 1 121406 0 0.02 0.996
mtr1a_human 107 3.32x32 TM3 M => I missense 8.237e-06 1 121404 0 0.04 0.058 LB (hydrophobic)
mtr1a_human 100 3.25x25 TM3 C => S missense 8.237e-06 1 121406 0 0.02 0.996
mtr1a_human 98 3.23x23 TM3 L => R missense 8.237e-06 1 121404 0 0.03 0.158
mtr1a_human 96 3.21x21 TM3 G => D missense 0.0007249 88 121402 0 0.0 0.86
mtr1a_human 92 23.49x49 ECL1 G => R missense 2.471e-05 3 121388 0 0.01 0.031
mtr1a_human 91 2.68x67 TM2 N => Y missense 8.238e-05 10 121390 0 0.01 0.043
mtr1a_human 88 2.65x64 TM2 I => V missense 5.767e-05 7 121370 0 0.12 0.02
mtr1a_human 87 2.64x63 TM2 S => L missense 1.648e-05 2 121358 0 0.0 0.108
mtr1a_human 82 2.59x58 TM2 P => L missense 1.65e-05 2 121230 0 0.04 0.997
mtr1a_human 80 2.57x56 TM2 P => L missense 4.127e-05 5 121154 0 0.0 0.031
mtr1a_human 80 2.57x56 TM2 P => A missense 8.255e-06 1 121146 0 0.02 0.292
mtr1a_human 75 2.52x52 TM2 V => L missense 2.484e-05 3 120792 0 0.68 0.006
mtr1a_human 70 2.47x47 TM2 A => V missense 3.323e-05 4 120382 0 0.01 0.973
mtr1a_human 68 2.45x45 TM2 S => R missense 1.665e-05 2 120150 0 0.0 0.931
mtr1a_human 65 2.42x42 TM2 F => S missense 8.359e-06 1 119630 0 0.01 0.946
mtr1a_human 64 2.41x41 TM2 I => M missense 8.379e-06 1 119350 0 0.16 0.043
mtr1a_human 64 2.41x41 TM2 I => V missense 8.379e-06 1 119350 0 0.3 0.008
mtr1a_human 63 2.40x40 TM2 N => S missense 8.385e-06 1 119264 0 0.0 0.999
mtr1a_human 57 12.49x49 ICL1 K => Q missense 9.815e-05 4 40756 0 0.02 0.564
mtr1a_human 56 12.48x48 ICL1 K => N missense 2.452e-05 1 40784 0 0.01 0.178
mtr1a_human 56 12.48x48 ICL1 K => R missense 2.447e-05 1 40870 0 0.91 0.013
mtr1a_human 54 1.59x59 TM1 R => W missense 0.001146 47 41024 0 0.0 0.378
mtr1a_human 52 1.57x57 TM1 V => A missense 0.001346 55 40864 0 0.0 0.938
mtr1a_human 51 1.56x56 TM1 S => L missense 4.967e-05 2 40268 0 0.0 0.228
mtr1a_human 50 1.55x55 TM1 L => P missense 2.531e-05 1 39504 0 0.0 0.928
mtr1a_human 49 1.54x54 TM1 I => T missense 2.516e-05 1 39748 0 0.03 0.385
mtr1a_human 48 1.53x53 TM1 V => I missense 2.57e-05 1 38912 0 0.02 0.458
mtr1a_human 32 1.37x37 TM1 C => S missense 4.815e-05 1 20768 0 0.73 0.0
mtr1a_human 31 1.36x36 TM1 A => V missense 4.965e-05 1 20140 0 0.05 0.206
mtr1a_human 18 N-term G => R missense 6.888e-05 1 14518 0 nan 0.004
mtr1a_human 10 N-term N => D missense 0.0003375 4 11852 0 0.38 0.002
mtr1a_human 9 N-term P => L missense 8.498e-05 1 11768 0 0.42 0.001
mtr1a_human 5 N-term G => R missense 0.0002958 3 10142 0 0.04 0.245


Residue

Diagrams

ICL1 K K L R ICL1ECL1 G W N L ECL1ICL2 S L K Y D K L Y ICL2ECL2 T L Q Y D P R I Y S C T F A Q S V ECL2ICL3 K P D R K ICL3ECL3 P A S M V P R I ECL3N-term M Q G N G S A L P N A S Q P V L R G D G A R N-termC-term A R V F F V D S S N D V A D R V K W K P S P L M T N N N V V K V D S V C-term P S W L A S A L A C V L I F T I V V D I L G N L L V I L S V Y R N N A G N I F V V S L A V A D L V V A I Y P Y P L V L M S I F N N G Y L H C Q V S G F L M G L S V I G S I F N I T G I A I N R Y C Y I C H S S K N S L C Y V L L I W L L T L A A V L P N L R A G S S A Y T I A V V V F H F L V P M I I V I F C Y L R I W I L V L Q V R Q R V P K L K P Q D F R N F V T M F V V F V L F A I C W A P L N F I G L A V A S D P E W L F V A S Y Y M A Y F N S C L N A I I Y G L L N Q N Y R R L C T F R K E I I V S
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