Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
nk1r_human 389 C-term R => Ter stop gained 8.261e-06 1 121056 0 None None
nk1r_human 364 C-term A => GlyfsTer28 frameshift 8.25e-06 1 121206 0 None None
nk1r_human 303 7.51x51 TM7 I => SerfsTer34 frameshift 8.236e-06 1 121412 0 None None
nk1r_human 192 5.34x35 TM5 Y => Ter stop gained 1.71e-05 2 116982 0 None None
nk1r_human 139 ICL2 Q => Ter stop gained 8.322e-06 1 120166 0 None None
nk1r_human 104 3.24x24 TM3 Y => Ter stop gained 1.647e-05 2 121412 0 None None
nk1r_human 103 3.23x23 TM3 F => ValfsTer27 frameshift 8.236e-06 1 121412 0 None None
nk1r_human 79 2.51x51 TM2 A => ProfsTer10 frameshift 4.118e-05 5 121412 0 None None
nk1r_human 35 1.35x35 TM1 W => Ter stop gained 8.275e-06 1 120842 0 None None
nk1r_human 20 N-term S => Ter stop gained 1.661e-05 2 120414 0 None None
nk1r_human 399 C-term F => L missense 8.271e-06 1 120910 0 1.0 0.0
nk1r_human 393 C-term K => E missense 8.262e-06 1 121030 0 0.03 0.722
nk1r_human 391 C-term D => N missense 8.262e-06 1 121042 0 0.66 0.001
nk1r_human 390 C-term S => T missense 8.261e-06 1 121048 0 0.08 0.015
nk1r_human 390 C-term S => N missense 8.261e-06 1 121048 0 0.08 0.368
nk1r_human 389 C-term R => G missense 8.261e-06 1 121056 0 0.04 0.005
nk1r_human 384 C-term S => C missense 2.478e-05 3 121088 0 0.12 0.052
nk1r_human 384 C-term S => P missense 8.258e-06 1 121092 0 0.15 0.809
nk1r_human 378 C-term S => L missense 0.0002394 29 121116 0 0.47 0.001
nk1r_human 377 C-term P => T missense 8.255e-06 1 121140 0 0.62 0.017
nk1r_human 376 C-term T => P missense 8.255e-06 1 121146 0 0.17 0.0
nk1r_human 372 C-term G => V missense 8.254e-06 1 121156 0 0.06 0.007
nk1r_human 369 C-term P => A missense 4.126e-05 5 121172 0 0.61 0.0
nk1r_human 366 C-term E => K missense 1.65e-05 2 121200 0 0.43 0.003
nk1r_human 365 C-term H => Q missense 0.0001073 13 121196 0 0.71 0.0
nk1r_human 365 C-term H => R missense 5.776e-05 7 121198 0 0.46 0.0
nk1r_human 361 C-term V => A missense 8.25e-06 1 121214 0 0.48 0.006
nk1r_human 357 C-term T => P missense 1.65e-05 2 121228 0 0.08 0.007
nk1r_human 354 C-term L => M missense 1.65e-05 2 121204 0 1.0 0.001
nk1r_human 353 C-term R => H missense 1.65e-05 2 121204 0 0.0 0.908
nk1r_human 353 C-term R => C missense 8.25e-06 1 121208 0 0.0 0.97
nk1r_human 352 C-term S => N missense 8.25e-06 1 121210 0 0.17 0.005
nk1r_human 351 C-term V => G missense 8.25e-06 1 121208 0 0.05 0.08
nk1r_human 348 C-term V => L missense 8.252e-06 1 121184 0 0.86 0.0
nk1r_human 347 C-term S => N missense 3.301e-05 4 121184 0 0.07 0.884 PTM (Phosphorylation)
nk1r_human 340 C-term R => Q missense 3.304e-05 4 121074 0 0.02 0.961
nk1r_human 340 C-term R => W missense 1.652e-05 2 121052 0 0.0 0.999
nk1r_human 330 C-term D => N missense 9.954e-05 12 120558 0 0.07 0.001
nk1r_human 329 C-term G => S missense 9.13e-05 11 120488 0 1.0 0.001
nk1r_human 328 C-term A => T missense 0.000166 20 120452 0 0.4 0.0
nk1r_human 321 C-term R => W missense 8.362e-05 10 119586 0 0.0 0.855
nk1r_human 319 8.57x57 H8 A => D missense 8.387e-06 1 119228 0 0.0 0.89
nk1r_human 317 8.55x55 H8 K => Q missense 2.534e-05 3 118408 0 0.23 0.109
nk1r_human 314 8.52x52 H8 L => M missense 1.712e-05 2 116852 0 0.07 0.004
nk1r_human 313 8.51x51 H8 R => H missense 5.148e-05 6 116554 0 0.01 0.992 GP (contact)
nk1r_human 313 8.51x51 H8 R => C missense 8.603e-06 1 116238 0 0.0 0.999 GP (contact)
nk1r_human 311 8.49x49 H8 R => S missense 8.669e-06 1 115360 0 0.0 0.995 GP (contact)
nk1r_human 310 8.48x48 H8 D => Y missense 8.236e-06 1 121412 0 0.02 0.948 GP (contact)
nk1r_human 304 7.52x52 TM7 I => N missense 8.236e-06 1 121412 0 0.0 0.999
nk1r_human 304 7.52x52 TM7 I => F missense 8.236e-06 1 121412 0 0.0 0.999
nk1r_human 303 7.51x51 TM7 I => V missense 1.647e-05 2 121412 0 0.04 0.159
nk1r_human 299 7.47x47 TM7 M => T missense 8.236e-06 1 121412 0 0.0 0.992
nk1r_human 291 7.39x38 TM7 M => I missense 2.471e-05 3 121412 0 0.02 0.641 LB (polar (hydrogen bond))
nk1r_human 291 7.39x38 TM7 M => T missense 8.236e-06 1 121412 0 0.0 0.992 LB (polar (hydrogen bond))
nk1r_human 285 7.33x32 TM7 Q => E missense 8.236e-06 1 121412 0 0.0 0.974
nk1r_human 273 6.60x60 TM6 I => L missense 8.238e-06 1 121394 0 0.37 0.003
nk1r_human 267 6.54x54 TM6 F => S missense 8.24e-06 1 121354 0 0.0 0.276 LB (hydrophobic, Van der Waals)
nk1r_human 266 6.53x53 TM6 I => L missense 6.593e-05 8 121340 0 0.49 0.016
nk1r_human 259 6.46x46 TM6 I => V missense 8.256e-06 1 121130 0 0.64 0.001
nk1r_human 258 6.45x45 TM6 A => T missense 8.258e-06 1 121098 0 0.0 0.813
nk1r_human 253 6.40x40 TM6 V => M missense 0.0007952 96 120722 0 0.0 1.0 GP (contact)
nk1r_human 253 6.40x40 TM6 V => L missense 8.283e-06 1 120722 0 0.01 0.989 GP (contact)
nk1r_human 244 6.31x31 TM6 R => H missense 9.024e-06 1 110814 0 0.04 0.937
nk1r_human 244 6.31x31 TM6 R => L missense 9.024e-06 1 110814 0 0.0 0.999
nk1r_human 240 6.27x27 TM6 V => A missense 0.0001706 19 111362 0 0.0 0.529
nk1r_human 240 6.27x27 TM6 V => F missense 8.976e-06 1 111404 0 0.01 0.657
nk1r_human 238 6.25x25 TM6 E => K missense 8.949e-06 1 111748 0 0.1 0.821 GP (contact)
nk1r_human 237 6.24x24 TM6 H => Q missense 2.681e-05 3 111912 0 0.46 0.004
nk1r_human 237 6.24x24 TM6 H => Q missense 8.936e-06 1 111912 0 0.46 0.004
nk1r_human 236 6.23x23 TM6 Y => S missense 8.919e-06 1 112124 0 0.02 0.978
nk1r_human 235 6.22x22 TM6 R => H missense 8.018e-05 9 112252 0 0.26 0.051
nk1r_human 235 6.22x22 TM6 R => C missense 2.663e-05 3 112672 0 0.02 0.978
nk1r_human 232 ICL3 S => Y missense 1.761e-05 2 113582 0 0.06 0.978
nk1r_human 232 ICL3 S => A missense 1.759e-05 2 113678 0 0.27 0.325
nk1r_human 222 5.64x64 TM5 T => S missense 8.438e-06 1 118506 0 0.08 0.229 GP (contact)
nk1r_human 221 5.63x63 TM5 I => M missense 8.433e-06 1 118588 0 0.12 0.054
nk1r_human 219 5.61x61 TM5 V => A missense 3.351e-05 4 119364 0 0.0 0.988 GP (contact)
nk1r_human 218 5.60x60 TM5 V => A missense 3.342e-05 4 119702 0 0.17 0.022
nk1r_human 218 5.60x60 TM5 V => I missense 2.506e-05 3 119732 0 0.95 0.001
nk1r_human 218 5.60x60 TM5 V => L missense 8.352e-06 1 119732 0 0.21 0.004
nk1r_human 215 5.57x57 TM5 A => V missense 8.306e-06 1 120396 0 0.0 0.728
nk1r_human 212 5.54x54 TM5 I => T missense 8.273e-06 1 120882 0 0.02 0.857
nk1r_human 202 5.44x45 TM5 V => M missense 2.476e-05 3 121140 0 0.02 0.08
nk1r_human 192 5.34x35 TM5 Y => F missense 8.541e-06 1 117088 0 1.0 0.0
nk1r_human 192 5.34x35 TM5 Y => H missense 8.528e-05 10 117264 0 0.37 0.555
nk1r_human 190 5.32x33 TM5 K => R missense 8.481e-06 1 117914 0 0.43 0.0
nk1r_human 188 5.30x31 TM5 P => L missense 5.875e-05 7 119140 0 0.11 0.004
nk1r_human 186 ECL2 E => Q missense 5.833e-05 7 120004 0 0.14 0.178
nk1r_human 183 ECL2 E => K missense 1.658e-05 2 120644 0 0.85 0.022
nk1r_human 181 45.51x51 ECL2 M => K missense 8.266e-06 1 120972 0 0.03 0.099 LB (hydrophobic, Van der Waals, polar (hydrogen bond))
nk1r_human 179 ECL2 V => A missense 8.258e-06 1 121094 0 0.02 0.729
nk1r_human 179 ECL2 V => M missense 8.257e-06 1 121110 0 0.03 0.863
nk1r_human 174 ECL2 M => T missense 1.649e-05 2 121284 0 0.41 0.023
nk1r_human 174 ECL2 M => V missense 8.245e-06 1 121288 0 0.48 0.001
nk1r_human 171 ECL2 T => R missense 8.243e-06 1 121322 0 0.04 0.952
nk1r_human 153 4.48x48 TM4 V => D missense 8.244e-06 1 121304 0 0.06 0.634
nk1r_human 153 4.48x48 TM4 V => L missense 8.244e-06 1 121294 0 0.53 0.004
nk1r_human 152 4.47x47 TM4 C => W missense 8.244e-06 1 121300 0 0.05 0.63
nk1r_human 152 4.47x47 TM4 C => S missense 8.244e-06 1 121300 0 0.18 0.021
nk1r_human 149 4.44x44 TM4 V => A missense 1.65e-05 2 121248 0 0.47 0.086
nk1r_human 144 4.39x39 TM4 A => D missense 8.266e-06 1 120972 0 0.0 0.806
nk1r_human 141 ICL2 R => Q missense 8.295e-06 1 120558 0 0.0 0.975
nk1r_human 135 3.55x55 TM3 I => T missense 1.678e-05 2 119174 0 0.0 0.758 GP (contact)
nk1r_human 127 3.47x47 TM3 A => T missense 8.244e-06 1 121304 0 0.03 0.988
nk1r_human 124 3.44x44 TM3 T => M missense 4.119e-05 5 121378 0 0.04 0.937
nk1r_human 124 3.44x44 TM3 T => K missense 8.239e-06 1 121378 0 0.0 0.963
nk1r_human 120 3.40x40 TM3 I => V missense 8.237e-06 1 121402 0 0.04 0.897 SodiumPocket MicroSwitch
nk1r_human 118 3.38x38 TM3 A => S missense 8.237e-06 1 121404 0 0.09 0.695
nk1r_human 116 3.36x36 TM3 V => L missense 8.237e-06 1 121406 0 0.02 0.653 LB (hydrophobic, Van der Waals)
nk1r_human 115 3.35x35 TM3 A => T missense 1.647e-05 2 121406 0 0.01 0.631
nk1r_human 114 3.34x34 TM3 A => T missense 8.237e-06 1 121408 0 1.0 0.021
nk1r_human 113 3.33x33 TM3 I => M missense 8.237e-06 1 121408 0 0.0 0.979 LB (polar (hydrogen bond with backbone), Van der Waals, hydrophobic)
nk1r_human 110 3.30x30 TM3 F => S missense 1.647e-05 2 121410 0 0.0 1.0
nk1r_human 107 3.27x27 TM3 F => S missense 8.236e-06 1 121412 0 0.0 0.998
nk1r_human 102 3.22x22 TM3 L => V missense 8.236e-05 10 121412 0 0.28 0.04
nk1r_human 101 3.21x21 TM3 G => D missense 8.236e-06 1 121412 0 0.0 0.977
nk1r_human 99 23.51x51 ECL1 Y => C missense 8.236e-06 1 121412 0 0.0 1.0
nk1r_human 97 23.49x49 ECL1 E => Q missense 8.236e-06 1 121412 0 0.16 0.619
nk1r_human 88 2.60x60 TM2 V => G missense 8.236e-06 1 121412 0 0.0 0.977
nk1r_human 86 2.58x58 TM2 T => A missense 8.236e-06 1 121412 0 0.28 0.368
nk1r_human 85 2.57x57 TM2 N => S missense 1.647e-05 2 121412 1 0.0 1.0 LB (polar (hydrogen bond), Van der Waals)
nk1r_human 81 2.53x53 TM2 M => K missense 8.236e-06 1 121412 0 0.0 0.987
nk1r_human 81 2.53x53 TM2 M => R missense 8.236e-06 1 121412 0 0.0 0.991
nk1r_human 80 2.52x52 TM2 S => T missense 1.647e-05 2 121412 0 0.05 0.953
nk1r_human 74 2.46x46 TM2 L => V missense 8.237e-06 1 121402 0 0.0 1.0
nk1r_human 73 2.45x45 TM2 N => Y missense 8.237e-06 1 121400 0 0.0 1.0
nk1r_human 65 2.37x37 TM2 T => R missense 8.24e-06 1 121358 0 0.0 1.0
nk1r_human 65 2.37x37 TM2 T => A missense 8.24e-06 1 121352 0 0.0 1.0
nk1r_human 59 1.59x59 TM1 A => T missense 8.248e-06 1 121246 0 0.0 0.999
nk1r_human 52 1.52x52 TM1 V => L missense 8.256e-06 1 121122 0 0.13 0.005
nk1r_human 51 1.51x51 TM1 V => M missense 8.258e-06 1 121102 0 0.06 0.274
nk1r_human 49 1.49x49 TM1 G => S missense 1.652e-05 2 121078 0 0.0 1.0
nk1r_human 49 1.49x49 TM1 G => R missense 1.652e-05 2 121078 0 0.0 1.0
nk1r_human 48 1.48x48 TM1 V => A missense 8.259e-06 1 121080 0 0.02 0.348
nk1r_human 47 1.47x47 TM1 V => L missense 8.262e-06 1 121040 0 0.04 0.047
nk1r_human 47 1.47x47 TM1 V => M missense 8.262e-06 1 121040 0 0.0 0.887
nk1r_human 45 1.45x45 TM1 T => N missense 8.261e-06 1 121050 0 0.0 0.315
nk1r_human 43 1.43x43 TM1 V => A missense 8.264e-06 1 121008 0 0.0 0.959
nk1r_human 42 1.42x42 TM1 I => V missense 8.264e-06 1 121010 0 0.69 0.007
nk1r_human 41 1.41x41 TM1 V => F missense 8.267e-06 1 120960 0 0.6 0.004
nk1r_human 40 1.40x40 TM1 T => R missense 8.27e-06 1 120912 0 0.29 0.132
nk1r_human 37 1.37x37 TM1 A => V missense 1.655e-05 2 120876 0 0.86 0.0
nk1r_human 32 1.32x32 TM1 I => V missense 8.279e-06 1 120794 0 0.8 0.024
nk1r_human 14 N-term N => D missense 8.33e-06 1 120042 0 0.22 0.004
nk1r_human 7 N-term V => M missense 8.404e-06 1 118988 0 0.21 0.001
nk1r_human 6 N-term P => R missense 8.421e-06 1 118748 0 0.47 0.294
nk1r_human 5 N-term L => R missense 2.53e-05 3 118568 0 0.03 0.049
nk1r_human 3 N-term N => K missense 8.482e-06 1 117900 0 0.02 0.014


Residue

Diagrams

ICL1 K R M R ICL1ECL1 E W Y Y ECL1ICL2 P L Q P R L ICL2ECL2 T T E T M P S R V V C M I E W P E H ECL2ICL3 S S D ICL3ECL3 P D L Y L K ECL3N-term M D N V L P V D S D L S P N I S T N T S E P N Q F V Q N-termC-term R C C P F I S A G D Y E G L E M K S T R Y L Q T Q G S V Y K V S R L E T T I S T V V G A H E E E P E D G P K A T P S S L D L T S N C S S R S D S K T M T E S F S F S S N V L S C-term P A W Q I V L W A A A Y T V I V V T S V V G N V V V M W I I L A H T V T N Y F L V N L A F A E A S M A A F N T V V N F T Y A V H N G L F Y C K F H N F F P I A A V F A S I Y S M T A V A F D R Y M A I I H S A T A T K V V I C V I W V L A L L L A F P Q G Y Y S P N K I Y E K V Y H I C V T V L I Y F L P L L V I G Y A Y T V V G I T L W A S E I P G D R Y H E Q V S A K R K V V K M M I V V V C T F A I C W L P F H I F F L L P Y I N K F I Q Q V Y L A I M W L A M S S T M Y N P I I Y C C L N D R F K H F R L G A F
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