Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
pe2r3_human 374 C-term L => LysfsTer48 frameshift 8.25e-06 1 121206 0 None None
pe2r3_human 389 C-term E => ValfsTer20 frameshift 8.243e-06 1 121308 0 None None
pe2r3_human 388 C-term L => SerfsTer21 frameshift 2.473e-05 3 121330 0 None None
pe2r3_human 380 C-term S => Ter stop gained 0.0005098 5 9808 0 None None
pe2r3_human 7 N-term Y => Ter stop gained 4.236e-05 1 23606 0 None None PTM (Phosphorylation)
pe2r3_human 389 C-term E => V missense 8.305e-06 1 120414 0 nan 0.025
pe2r3_human 387 C-term H => L missense 4.144e-05 5 120654 0 nan 0.0
pe2r3_human 386 C-term D => N missense 1.657e-05 2 120698 0 nan 0.003
pe2r3_human 381 C-term T => I missense 8.271e-06 1 120910 0 nan 0.031
pe2r3_human 380 C-term S => L missense 8.271e-06 1 120908 0 nan 0.916
pe2r3_human 380 C-term S => A missense 8.27e-06 1 120926 0 nan 0.746
pe2r3_human 378 C-term C => R missense 8.27e-06 1 120920 0 nan 0.058
pe2r3_human 375 C-term P => L missense 0.001406 170 120912 2 nan 0.987
pe2r3_human 375 C-term P => H missense 8.27e-06 1 120912 0 nan 0.994
pe2r3_human 371 C-term S => F missense 1.655e-05 2 120882 0 0.0 0.974
pe2r3_human 369 8.66x66 H8 S => F missense 8.273e-06 1 120868 0 0.04 0.974
pe2r3_human 366 8.63x63 H8 N => S missense 0.004826 583 120806 9 0.59 0.001
pe2r3_human 365 8.62x62 H8 N => S missense 1.656e-05 2 120786 0 1.0 0.001
pe2r3_human 355 8.52x52 H8 R => Q missense 8.244e-06 1 121306 0 0.12 0.132
pe2r3_human 320 7.27x26 TM7 E => K missense 8.249e-06 1 121220 0 0.26 0.41
pe2r3_human 319 7.26x25 TM7 T => M missense 0.0003382 41 121218 0 0.1 0.046
pe2r3_human 319 7.26x25 TM7 T => K missense 8.25e-06 1 121218 0 0.52 0.069
pe2r3_human 314 ECL3 H => P missense 8.253e-06 1 121168 0 0.05 0.811
pe2r3_human 310 6.63x63 TM6 T => I missense 1.652e-05 2 121082 0 0.04 0.14
pe2r3_human 310 6.63x63 TM6 T => A missense 1.652e-05 2 121068 0 0.1 0.403
pe2r3_human 301 6.54x54 TM6 M => K missense 3.343e-05 4 119662 0 0.03 0.572
pe2r3_human 293 6.46x46 TM6 V => I missense 9.09e-06 1 110012 0 1.0 0.123
pe2r3_human 290 6.43x43 TM6 V => M missense 8.96e-06 1 111606 0 0.0 0.999
pe2r3_human 286 6.39x39 TM6 G => A missense 3.517e-05 4 113726 0 0.0 1.0
pe2r3_human 285 6.38x38 TM6 M => I missense 8.757e-06 1 114196 0 0.03 0.403
pe2r3_human 283 6.36x36 TM6 Q => H missense 8.683e-06 1 115174 0 0.0 1.0 GP (contact)
pe2r3_human 280 6.33x33 TM6 T => M missense 8.549e-06 1 116966 0 0.6 1.0 GP (contact)
pe2r3_human 279 6.32x32 TM6 E => K missense 8.506e-06 1 117564 0 0.0 1.0 GP (contact)
pe2r3_human 274 6.27x27 TM6 G => S missense 8.369e-06 1 119492 0 0.33 0.973
pe2r3_human 270 6.23x23 TM6 S => R missense 1.665e-05 2 120152 0 0.17 0.158
pe2r3_human 269 6.22x22 TM6 S => T missense 8.316e-06 1 120250 0 0.09 0.84
pe2r3_human 264 5.73x73 TM5 A => T missense 8.294e-06 1 120568 0 0.28 0.145
pe2r3_human 262 5.71x71 TM5 A => T missense 3.316e-05 4 120626 0 0.57 0.241 GP (contact)
pe2r3_human 255 5.64x64 TM5 A => T missense 8.275e-06 1 120844 0 0.28 0.995 GP (contact)
pe2r3_human 239 5.48x48 TM5 L => F missense 1.66e-05 2 120514 0 0.0 0.995
pe2r3_human 236 5.45x45 TM5 F => L missense 8.319e-06 1 120212 0 0.77 0.152
pe2r3_human 235 5.44x44 TM5 A => V missense 2.498e-05 3 120090 0 0.0 0.986
pe2r3_human 233 5.42x42 TM5 A => T missense 8.358e-06 1 119646 0 0.46 0.016
pe2r3_human 231 5.40x40 TM5 A => V missense 8.375e-06 1 119408 0 0.3 0.995
pe2r3_human 231 5.40x40 TM5 A => T missense 8.38e-06 1 119326 0 0.06 0.986
pe2r3_human 228 5.37x37 TM5 L => F missense 2.523e-05 3 118904 0 0.02 0.689
pe2r3_human 226 5.35x35 TM5 G => C missense 8.445e-06 1 118420 0 0.02 0.998
pe2r3_human 226 5.35x35 TM5 G => S missense 1.689e-05 2 118420 0 0.14 0.973
pe2r3_human 224 ECL2 N => Y missense 8.46e-06 1 118208 0 0.02 0.56
pe2r3_human 218 ECL2 G => V missense 8.534e-06 1 117184 0 0.02 0.752
pe2r3_human 218 ECL2 G => R missense 8.537e-06 1 117132 0 0.01 0.842
pe2r3_human 216 ECL2 G => S missense 8.574e-06 1 116630 0 0.13 0.861
pe2r3_human 215 ECL2 G => R missense 8.586e-06 1 116466 0 0.12 0.984
pe2r3_human 213 ECL2 G => W missense 1.727e-05 2 115792 0 0.01 0.996
pe2r3_human 200 ECL2 T => A missense 2.582e-05 3 116200 0 0.13 0.12
pe2r3_human 198 ECL2 Q => H missense 2.586e-05 3 116018 0 0.15 0.033
pe2r3_human 196 ECL2 V => M missense 8.659e-06 1 115492 0 0.01 0.995
pe2r3_human 182 4.50x50 TM4 W => C missense 9.017e-06 1 110906 0 0.02 0.998
pe2r3_human 181 4.49x49 TM4 V => L missense 4.545e-05 5 110020 0 0.12 0.906
pe2r3_human 181 4.49x49 TM4 V => M missense 2.727e-05 3 110020 0 0.01 0.903
pe2r3_human 179 4.47x47 TM4 L => F missense 9.264e-06 1 107944 0 0.17 0.16
pe2r3_human 176 4.44x44 TM4 A => G missense 9.513e-06 1 105120 0 0.21 0.314
pe2r3_human 175 4.43x43 TM4 R => L missense 7.748e-05 8 103252 0 0.0 0.804
pe2r3_human 173 4.41x41 TM4 A => T missense 1.006e-05 1 99406 0 0.4 0.507
pe2r3_human 172 4.40x40 TM4 R => L missense 1.006e-05 1 99374 0 0.04 0.899
pe2r3_human 172 4.40x40 TM4 R => G missense 1.018e-05 1 98216 0 0.05 0.191
pe2r3_human 169 34.57x57 ICL2 M => L missense 6.482e-05 6 92570 0 0.14 0.044 GP (contact)
pe2r3_human 169 34.57x57 ICL2 M => V missense 1.08e-05 1 92570 0 0.48 0.129 GP (contact)
pe2r3_human 167 34.55x55 ICL2 S => C missense 1.124e-05 1 88998 0 0.02 0.289 GP (contact)
pe2r3_human 164 34.52x52 ICL2 W => R missense 1.217e-05 1 82178 0 0.0 0.998 GP (contact)
pe2r3_human 163 34.51x51 ICL2 H => Q missense 1.224e-05 1 81666 0 0.03 1.0 GP (contact)
pe2r3_human 151 3.46x46 TM3 M => V missense 1.498e-05 1 66762 0 0.0 0.998
pe2r3_human 147 3.42x42 TM3 I => T missense 1.537e-05 1 65066 0 0.0 0.752
pe2r3_human 147 3.42x42 TM3 I => L missense 4.599e-05 3 65236 0 1.0 0.047
pe2r3_human 144 3.39x39 TM3 S => P missense 1.557e-05 1 64216 0 1.0 0.05
pe2r3_human 125 ECL1 P => S missense 1.697e-05 1 58926 0 0.16 0.189
pe2r3_human 123 ECL1 I => V missense 1.698e-05 1 58898 0 0.45 0.006
pe2r3_human 119 23.49x49 ECL1 R => P missense 1.718e-05 1 58218 0 0.26 0.026
pe2r3_human 119 23.49x49 ECL1 R => C missense 1.718e-05 1 58222 0 0.03 0.892
pe2r3_human 118 ECL1 Q => E missense 1.722e-05 1 58084 0 0.66 0.309
pe2r3_human 113 2.64x64 TM2 V => A missense 1.756e-05 1 56952 0 0.01 0.927
pe2r3_human 112 2.63x63 TM2 V => F missense 0.000158 9 56972 0 0.71 0.041
pe2r3_human 94 2.45x45 TM2 W => C missense 1.535e-05 1 65154 0 0.08 0.033
pe2r3_human 94 2.45x45 TM2 W => G missense 0.000363 24 66122 0 0.3 0.013
pe2r3_human 92 2.43x43 TM2 I => V missense 1.461e-05 1 68434 0 0.21 0.951
pe2r3_human 85 2.36x36 TM2 K => R missense 8.195e-05 6 73212 0 0.01 0.521
pe2r3_human 83 ICL1 K => N missense 1.34e-05 1 74616 0 0.0 0.827
pe2r3_human 83 ICL1 K => T missense 0.0001065 8 75090 0 0.02 0.259
pe2r3_human 82 ICL1 S => T missense 1.316e-05 1 75974 0 0.05 0.752
pe2r3_human 82 ICL1 S => C missense 1.305e-05 1 76600 0 0.01 0.967
pe2r3_human 81 ICL1 E => V missense 1.295e-05 1 77248 0 0.0 0.997
pe2r3_human 81 ICL1 E => Q missense 1.29e-05 1 77530 0 0.02 0.994
pe2r3_human 80 ICL1 R => Q missense 1.279e-05 1 78166 0 0.34 0.888
pe2r3_human 70 1.54x54 TM1 M => V missense 2.167e-05 2 92280 0 0.0 0.378
pe2r3_human 53 1.37x37 TM1 A => V missense 2.013e-05 2 99346 0 0.25 0.018
pe2r3_human 45 N-term E => K missense 1.057e-05 1 94600 0 0.19 0.294
pe2r3_human 44 N-term G => A missense 1.065e-05 1 93890 0 0.37 0.003
pe2r3_human 42 N-term G => R missense 0.0004063 37 91060 0 0.25 0.013
pe2r3_human 39 N-term R => S missense 1.145e-05 1 87350 0 0.4 0.011
pe2r3_human 38 N-term T => K missense 1.145e-05 1 87356 0 0.01 0.693
pe2r3_human 34 N-term R => P missense 3.734e-05 3 80334 0 0.17 0.024
pe2r3_human 33 N-term A => E missense 0.0001375 11 79974 0 0.22 0.021
pe2r3_human 28 N-term E => Q missense 4.231e-05 3 70910 0 0.06 0.104
pe2r3_human 28 N-term E => K missense 1.41e-05 1 70910 0 0.09 0.216
pe2r3_human 24 N-term M => V missense 1.513e-05 1 66074 0 nan 0.02
pe2r3_human 19 N-term H => Y missense 1.909e-05 1 52388 0 0.04 0.111
pe2r3_human 17 N-term L => F missense 2.019e-05 1 49526 0 0.05 0.031
pe2r3_human 16 N-term R => H missense 6.224e-05 3 48202 0 0.04 0.03
pe2r3_human 16 N-term R => S missense 2.19e-05 1 45672 0 0.07 0.507
pe2r3_human 14 N-term C => R missense 0.0001292 5 38690 0 nan 0.979
pe2r3_human 8 N-term G => E missense 3.792e-05 1 26374 0 0.05 0.466
pe2r3_human 5 N-term R => Q missense 4.805e-05 1 20812 0 nan 0.968


Residue

Diagrams

ICL1 R R E S K R ICL1ECL1 Q R W E H I D P S ECL1ICL2 P H W Y A S H M ICL2ECL2 V G Q Y T V Q W P G T W C F I S T G R G G N G T S S S H N ECL2ICL3 T A S Q ICL3ECL3 V E H C K ECL3N-term M K E T R G Y G G D A P F C T R L N H S Y T G M W A P E R S A E A R G N L T R P P G S G E D C G S V S N-termC-term S S T S L P C Q C S S T L M W S D H L E R C-term V A F P I T M L L T G F V G N A L A M L L V S R S Y R K K S F L L C I G W L A L T D L V G Q L L T T P V V I V V Y L S K G R L C T F F G L T M T V F G L S S L F I A S A M A V E R A L A I R A K T R A T R A V L L G V W L A V L A F A L L P V L G W G N L F F A S A F A F L G L L A L T V T F S C N L A T I K A L V S R C R A K A S S A Q W G R I T T E T A I Q L M G I M C V L S V C W S P L L I M M L K M I F N Q T S T H T E K Q K E C N F F L I A V R L A S L N Q I L D P W V Y L L L R K I F C Q T N N L L R K I R Y H Y A S
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