Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ssr1_human 60 1.34x34 TM1 L => Ter frameshift 8.582e-06 1 116520 0 None None
ssr1_human 100 2.46x46 TM2 L => ArgfsTer15 frameshift 8.238e-06 1 121388 0 None None
ssr1_human 149 3.44x44 TM3 T => CysfsTer27 frameshift 8.241e-06 1 121342 0 None None
ssr1_human 181 4.49x49 TM4 V => CysfsTer91 frameshift 8.255e-06 1 121146 0 None None
ssr1_human 240 5.55x55 TM5 C => TyrfsTer11 frameshift 8.25e-06 1 121216 0 None None
ssr1_human 4 N-term N => S missense 2.649e-05 1 37748 0 nan 0.0
ssr1_human 16 N-term P => T missense 0.002015 119 59054 0 0.65 0.0
ssr1_human 19 N-term G => D missense 3.08e-05 2 64942 0 0.43 0.0
ssr1_human 23 N-term E => K missense 2.839e-05 2 70438 0 0.24 0.0
ssr1_human 24 N-term G => D missense 1.39e-05 1 71954 0 0.12 0.0
ssr1_human 25 N-term G => D missense 2.722e-05 2 73474 0 0.4 0.0
ssr1_human 26 N-term G => R missense 6.721e-05 5 74396 0 0.56 0.0
ssr1_human 26 N-term G => D missense 1.336e-05 1 74858 0 0.69 0.0
ssr1_human 28 N-term R => K missense 1.274e-05 1 78496 0 0.31 0.0
ssr1_human 29 N-term G => D missense 0.0001627 13 79882 0 0.28 0.0
ssr1_human 33 N-term G => R missense 2.256e-05 2 88656 0 0.12 0.0
ssr1_human 33 N-term G => A missense 2.237e-05 2 89416 0 0.37 0.0
ssr1_human 37 N-term G => C missense 2.008e-05 2 99598 0 0.0 0.981
ssr1_human 37 N-term G => V missense 9.982e-06 1 100182 0 0.03 0.953
ssr1_human 39 N-term E => K missense 9.643e-06 1 103698 0 0.81 0.004
ssr1_human 41 N-term P => Q missense 3.744e-05 4 106848 0 0.11 0.014
ssr1_human 42 N-term G => E missense 9.259e-06 1 108008 0 0.4 0.931
ssr1_human 44 N-term N => K missense 9.096e-06 1 109936 0 0.03 0.932
ssr1_human 45 N-term A => V missense 0.0002544 28 110070 0 0.53 0.0
ssr1_human 45 N-term A => E missense 9.085e-06 1 110070 0 0.41 0.001
ssr1_human 46 N-term S => P missense 7.223e-05 8 110752 0 0.11 0.047
ssr1_human 48 N-term N => K missense 8.938e-06 1 111876 0 0.16 0.962
ssr1_human 49 N-term G => R missense 1.783e-05 2 112168 0 0.27 0.481
ssr1_human 52 N-term S => R missense 8.822e-06 1 113354 0 0.42 0.089
ssr1_human 56 1.30x30 TM1 G => D missense 8.694e-06 1 115016 0 0.58 0.461
ssr1_human 61 1.35x35 TM1 I => N missense 8.526e-06 1 117292 0 0.0 0.948
ssr1_human 68 1.42x42 TM1 V => E missense 1.673e-05 2 119548 0 0.0 0.954
ssr1_human 78 1.52x52 TM1 M => V missense 2.477e-05 3 121132 0 0.03 0.002
ssr1_human 82 1.56x56 TM1 V => L missense 1.649e-05 2 121280 0 0.02 0.964
ssr1_human 87 12.48x48 ICL1 A => V missense 8.24e-06 1 121354 0 0.01 0.983
ssr1_human 91 2.37x37 TM2 T => R missense 8.239e-06 1 121376 0 0.0 0.996
ssr1_human 92 2.38x38 TM2 A => T missense 8.239e-06 1 121374 0 0.01 0.989
ssr1_human 92 2.38x38 TM2 A => S missense 1.648e-05 2 121374 0 0.0 0.983
ssr1_human 93 2.39x39 TM2 T => A missense 4.119e-05 5 121378 0 0.03 0.973
ssr1_human 99 2.45x45 TM2 N => K missense 8.238e-06 1 121390 0 0.0 0.982
ssr1_human 118 2.64x64 TM2 T => A missense 8.239e-06 1 121370 0 0.8 0.006 PTM (Phosphorylation)
ssr1_human 121 ECL1 R => H missense 1.648e-05 2 121368 0 0.38 0.002
ssr1_human 126 3.21x21 TM3 G => C missense 8.239e-06 1 121372 0 0.0 0.999
ssr1_human 130 3.25x25 TM3 C => R missense 8.24e-06 1 121362 0 0.0 0.99
ssr1_human 137 3.32x32 TM3 D => V missense 8.24e-06 1 121356 0 0.0 0.997 LB (polar (charge-assisted hydrogen bond))
ssr1_human 137 3.32x32 TM3 D => E missense 1.648e-05 2 121356 0 0.0 0.991 LB (polar (charge-assisted hydrogen bond))
ssr1_human 143 3.38x38 TM3 T => S missense 8.241e-06 1 121350 0 0.05 0.973
ssr1_human 152 3.47x47 TM3 S => N missense 1.648e-05 2 121332 0 0.0 0.95
ssr1_human 153 3.48x48 TM3 V => L missense 7.418e-05 9 121322 0 0.13 0.013
ssr1_human 157 3.52x52 TM3 V => L missense 4.121e-05 5 121320 0 1.0 0.093
ssr1_human 161 3.56x56 TM3 H => R missense 8.245e-06 1 121282 0 0.03 0.954 GP (contact)
ssr1_human 162 34.50x50 ICL2 P => L missense 8.248e-06 1 121248 0 0.01 0.995 GP (contact)
ssr1_human 164 34.52x52 ICL2 K => Q missense 2.475e-05 3 121228 0 0.03 0.324 GP (contact)
ssr1_human 165 34.53x53 ICL2 A => V missense 8.25e-06 1 121208 0 0.02 0.984 GP (contact)
ssr1_human 167 34.55x55 ICL2 R => S missense 8.252e-06 1 121188 0 0.1 0.015 GP (contact)
ssr1_human 167 34.55x55 ICL2 R => C missense 8.252e-06 1 121188 0 0.0 0.761 GP (contact)
ssr1_human 168 34.56x56 ICL2 Y => C missense 8.252e-06 1 121184 0 0.06 0.996 GP (contact)
ssr1_human 176 4.44x44 TM4 V => A missense 8.254e-06 1 121150 0 0.31 0.042
ssr1_human 185 4.53x53 TM4 S => T missense 8.253e-06 1 121162 0 0.0 0.95
ssr1_human 199 ECL2 A => V missense 8.252e-06 1 121182 0 0.32 0.984
ssr1_human 200 ECL2 A => T missense 8.253e-06 1 121174 0 0.41 0.003
ssr1_human 202 ECL2 S => N missense 8.251e-06 1 121198 0 0.57 0.007
ssr1_human 204 ECL2 G => C missense 1.65e-05 2 121204 0 0.0 0.999
ssr1_human 205 ECL2 T => M missense 8.25e-06 1 121206 0 0.33 0.871
ssr1_human 206 ECL2 V => A missense 4.125e-05 5 121214 0 0.51 0.959
ssr1_human 210 45.52x52 ECL2 M => V missense 8.249e-06 1 121234 0 0.07 0.001 LB (hydrophobic, Van der Waals)
ssr1_human 217 5.32x33 TM5 Q => P missense 8.248e-06 1 121244 0 0.13 0.224
ssr1_human 218 5.33x34 TM5 R => H missense 8.248e-06 1 121244 0 0.14 0.44
ssr1_human 222 5.37x38 TM5 G => D missense 8.249e-06 1 121232 0 0.0 0.481
ssr1_human 224 5.39x40 TM5 V => M missense 8.247e-06 1 121250 0 0.09 0.898
ssr1_human 230 5.45x46 TM5 M => T missense 8.247e-06 1 121252 0 0.0 0.855
ssr1_human 234 5.49x49 TM5 L => M missense 8.249e-06 1 121226 0 0.25 0.761
ssr1_human 235 5.50x50 TM5 P => T missense 8.249e-06 1 121232 0 0.0 0.995 SodiumPocket MicroSwitch
ssr1_human 236 5.51x51 TM5 V => M missense 8.249e-06 1 121220 0 0.02 0.055
ssr1_human 236 5.51x51 TM5 V => L missense 8.249e-06 1 121220 0 1.0 0.092
ssr1_human 237 5.52x52 TM5 G => E missense 8.249e-06 1 121222 0 0.0 0.123
ssr1_human 240 5.55x55 TM5 C => G missense 8.248e-06 1 121244 0 0.19 0.966
ssr1_human 242 5.57x57 TM5 C => F missense 8.248e-06 1 121242 0 0.0 0.99
ssr1_human 246 5.61x61 TM5 I => M missense 8.247e-06 1 121258 0 0.02 0.98 GP (contact)
ssr1_human 250 5.65x65 TM5 M => T missense 8.247e-06 1 121256 0 0.02 0.063 GP (contact)
ssr1_human 250 5.65x65 TM5 M => I missense 2.474e-05 3 121256 0 0.16 0.001 GP (contact)
ssr1_human 251 5.66x66 TM5 R => C missense 0.000132 16 121256 0 0.0 0.993 GP (contact)
ssr1_human 251 5.66x66 TM5 R => G missense 8.247e-06 1 121256 0 0.0 0.982 GP (contact)
ssr1_human 252 5.67x67 TM5 M => L missense 1.649e-05 2 121264 0 0.01 0.003 GP (contact)
ssr1_human 252 5.67x67 TM5 M => I missense 4.124e-05 5 121254 0 0.01 0.006 GP (contact)
ssr1_human 255 5.70x70 TM5 L => V missense 8.248e-05 10 121248 0 0.67 0.973
ssr1_human 258 5.73x73 TM5 G => R missense 1.649e-05 2 121258 0 0.04 0.999
ssr1_human 262 ICL3 R => S missense 1.649e-05 2 121272 0 0.03 0.982
ssr1_human 264 ICL3 R => C missense 4.122e-05 5 121290 0 0.06 0.761
ssr1_human 264 ICL3 R => G missense 8.245e-06 1 121290 0 0.03 0.219
ssr1_human 268 6.32x32 TM6 K => E missense 8.241e-06 1 121350 0 0.0 0.973 GP (contact)
ssr1_human 271 6.35x35 TM6 L => V missense 8.239e-06 1 121368 0 0.02 0.037
ssr1_human 275 6.39x39 TM6 M => I missense 8.238e-06 1 121394 0 1.0 0.017
ssr1_human 276 6.40x40 TM6 V => L missense 3.295e-05 4 121394 0 0.04 0.935 GP (contact)
ssr1_human 288 6.52x52 TM6 Y => F missense 1.647e-05 2 121402 0 0.3 0.376
ssr1_human 293 6.57x57 TM6 V => I missense 1.647e-05 2 121410 0 0.18 0.935
ssr1_human 294 6.58x58 TM6 N => H missense 1.647e-05 2 121408 0 0.01 0.596
ssr1_human 303 7.33x32 TM7 T => M missense 8.237e-06 1 121408 0 0.28 0.856
ssr1_human 308 7.38x37 TM7 S => P missense 8.237e-06 1 121406 0 0.03 0.562
ssr1_human 312 7.42x41 TM7 G => C missense 0.0001071 13 121404 0 0.01 0.999
ssr1_human 318 7.48x48 TM7 A => T missense 8.237e-06 1 121404 0 0.04 0.989
ssr1_human 319 7.49x49 TM7 N => K missense 8.237e-06 1 121402 0 0.0 0.982 SodiumPocket MicroSwitch
ssr1_human 320 7.50x50 TM7 P => S missense 1.647e-05 2 121400 0 0.0 0.992 SodiumPocket MicroSwitch
ssr1_human 320 7.50x50 TM7 P => R missense 8.237e-06 1 121402 0 0.0 0.997 SodiumPocket MicroSwitch
ssr1_human 325 7.55x55 TM7 F => C missense 8.237e-06 1 121400 0 0.04 0.971 GP (contact)
ssr1_human 326 7.56x56 TM7 L => F missense 1.647e-05 2 121400 0 0.01 0.969 GP (contact)
ssr1_human 332 8.52x52 H8 R => H missense 8.238e-06 1 121396 0 0.13 0.964
ssr1_human 334 8.54x54 H8 F => S missense 8.238e-06 1 121396 0 0.01 0.91
ssr1_human 336 8.56x56 H8 R => S missense 8.238e-06 1 121394 0 0.02 0.071
ssr1_human 337 8.57x57 H8 I => V missense 1.648e-05 2 121394 0 1.0 0.001
ssr1_human 350 C-term P => Q missense 8.242e-06 1 121324 0 0.07 0.993
ssr1_human 359 C-term K => E missense 8.256e-06 1 121126 0 0.17 0.091
ssr1_human 361 C-term R => G missense 8.262e-06 1 121042 0 0.0 0.931
ssr1_human 362 C-term A => V missense 8.266e-06 1 120982 0 0.46 0.102
ssr1_human 364 C-term S => N missense 1.654e-05 2 120892 0 0.33 0.827
ssr1_human 368 C-term F => L missense 8.301e-06 1 120464 0 0.6 0.0
ssr1_human 368 C-term F => Y missense 8.303e-06 1 120432 0 0.7 0.001
ssr1_human 373 C-term L => R missense 1.683e-05 2 118856 0 0.18 0.06
ssr1_human 377 C-term G => R missense 8.554e-06 1 116898 0 nan 0.501
ssr1_human 380 C-term R => H missense 1.732e-05 2 115488 0 nan 0.289
ssr1_human 382 C-term G => V missense 8.76e-06 1 114152 0 nan 0.994
ssr1_human 384 C-term C => S missense 2.642e-05 3 113530 0 nan 0.879
ssr1_human 384 C-term C => S missense 3.534e-05 4 113198 0 nan 0.879
ssr1_human 385 C-term T => K missense 8.893e-06 1 112452 0 nan 0.972 PTM (Phosphorylation)
ssr1_human 387 C-term R => G missense 1.883e-05 2 106230 0 nan 0.931


Residue

Diagrams

ICL1 A K M K ICL1ECL1 R H W P F ECL1ICL2 P I K A A R Y R ICL2ECL2 R T A A N S D G T V A C N M L M P E ECL2ICL3 W Q Q R K R S ICL3ECL3 E Q D ECL3N-term M F P N G T A S S P S S S P S P S P G S C G E G G G S R G P G A G A A D G M E E P G R N A S Q N G T L S N-termC-term L S W M D N A A E E P V D Y Y A T A L K S R A Y S V E D F Q P E N L E S G G V F R N G T C T S R I T T L C-term E G Q G S A I L I S F I Y S V V C L V G L C G N S M V I Y V I L R Y T A T N I Y I L N L A I A D E L L M L S V P F L V T S T L L G A L L C R L V L S V D A V N M F T S I Y C L T V L S V D R Y V A V V H R P T V A K V V N L G V W V L S L L V I L P I V V F S P A Q R W L V G F V L Y T F L M G F L L P V G A I C L C Y V L I I A K M R M V A L K A G E R K I T L M V M M V V M V F V I C W M P F Y V V Q L V N V F A D A T V S Q L S V I L G Y A N S C A N P I L Y G F L S D N F Q R F K R S I L C
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