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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ssr5_human 4 N-term L => ValfsTer21 frameshift 3.122e-05 3 96088 0 None None
ssr5_human 42 1.34x34 TM1 L => TrpfsTer30 frameshift 1.648e-05 1 60682 0 None None
ssr5_human 123 3.36x36 TM3 Q => Ter stop gained 8.41e-06 1 118906 0 None None
ssr5_human 166 4.52x52 TM4 L => ArgfsTer61 frameshift 1.068e-05 1 93592 0 None None
ssr5_human 197 5.34x35 TM5 W => Ter stop gained 9.891e-06 1 101106 0 None None
ssr5_human 237 6.24x24 TM6 C => TrpfsTer12 frameshift 8.622e-06 1 115986 0 None None
ssr5_human 308 8.47x47 H8 S => ThrfsTer82 frameshift 4.186e-05 5 119456 0 None None GP (contact)
ssr5_human 7 N-term A => D missense 2.146e-05 2 93176 0 0.39 0.371
ssr5_human 8 N-term S => T missense 1.077e-05 1 92812 0 0.4 0.011
ssr5_human 9 N-term T => M missense 0.001259 115 91372 0 0.33 0.056
ssr5_human 9 N-term T => R missense 1.094e-05 1 91372 0 0.5 0.019
ssr5_human 14 N-term A => T missense 0.0006265 53 84602 0 0.66 0.006
ssr5_human 17 N-term P => L missense 8.831e-05 7 79266 0 0.31 0.004
ssr5_human 17 N-term P => R missense 3.785e-05 3 79266 0 0.34 0.242
ssr5_human 18 N-term G => R missense 0.0001389 11 79166 0 0.14 0.005
ssr5_human 24 N-term G => S missense 8.394e-05 6 71482 0 0.99 0.003
ssr5_human 26 N-term N => Y missense 1.416e-05 1 70638 0 0.03 0.957
ssr5_human 28 N-term T => M missense 5.826e-05 4 68656 0 0.0 0.927
ssr5_human 32 N-term P => L missense 9.65e-05 6 62174 0 0.35 0.003
ssr5_human 33 N-term A => V missense 7.981e-05 5 62646 0 0.57 0.006
ssr5_human 35 N-term S => L missense 1.631e-05 1 61318 0 0.33 0.006
ssr5_human 37 1.29x29 TM1 G => R missense 3.373e-05 2 59296 0 0.2 0.892
ssr5_human 39 1.31x31 TM1 R => Q missense 0.000207 12 57968 0 0.31 0.016
ssr5_human 40 1.32x32 TM1 A => V missense 6.793e-05 4 58884 0 0.1 0.014
ssr5_human 45 1.37x37 TM1 V => L missense 1.568e-05 1 63794 0 1.0 0.025
ssr5_human 45 1.37x37 TM1 V => M missense 1.568e-05 1 63794 0 0.04 0.632
ssr5_human 46 1.38x38 TM1 L => P missense 1.514e-05 1 66054 0 0.0 0.966
ssr5_human 48 1.40x40 TM1 L => M missense 0.05283 3677 69606 92 0.08 0.998
ssr5_human 52 1.44x44 TM1 A => V missense 0.08092 6301 77866 332 1.0 0.014
ssr5_human 54 1.46x46 TM1 G => R missense 1.18e-05 1 84780 0 0.0 1.0
ssr5_human 58 1.50x50 TM1 N => T missense 1.031e-05 1 96948 0 0.02 0.999
ssr5_human 62 1.54x54 TM1 I => L missense 1.889e-05 2 105884 0 0.0 0.527
ssr5_human 63 1.55x55 TM1 Y => H missense 9.333e-06 1 107152 0 0.16 0.975
ssr5_human 67 1.59x59 TM1 R => C missense 0.0001068 12 112340 0 0.02 0.135 PTM (Methylation)
ssr5_human 69 12.48x48 ICL1 A => T missense 8.718e-06 1 114708 0 0.33 0.174
ssr5_human 74 2.38x38 TM2 V => I missense 2.553e-05 3 117492 0 0.09 0.753
ssr5_human 85 2.49x49 TM2 A => V missense 8.413e-06 1 118868 0 0.0 0.999
ssr5_human 86 2.50x50 TM2 D => N missense 5.045e-05 6 118930 0 0.0 1.0
ssr5_human 87 2.51x51 TM2 V => I missense 2.521e-05 3 118978 0 0.03 0.135
ssr5_human 90 2.54x54 TM2 M => V missense 8.398e-06 1 119082 0 0.02 0.345
ssr5_human 93 2.57x57 TM2 L => M missense 8.396e-06 1 119104 0 0.0 1.0
ssr5_human 93 2.57x57 TM2 L => R missense 1.679e-05 2 119124 0 0.0 1.0
ssr5_human 98 2.62x62 TM2 T => M missense 8.39e-06 1 119194 0 0.1 0.994
ssr5_human 101 2.65x65 TM2 A => T missense 8.388e-05 10 119220 0 0.06 0.283
ssr5_human 102 2.66x66 TM2 A => T missense 0.000109 13 119236 0 0.0 0.196
ssr5_human 107 23.52x52 ECL1 F => C missense 8.39e-06 1 119196 0 0.0 0.999
ssr5_human 108 3.21x21 TM3 G => S missense 2.517e-05 3 119188 0 0.0 1.0
ssr5_human 109 3.22x22 TM3 P => S missense 0.05714 6809 119162 325 1.0 0.026
ssr5_human 109 3.22x22 TM3 P => T missense 8.392e-06 1 119162 0 0.1 0.257
ssr5_human 110 3.23x23 TM3 V => I missense 0.0002098 25 119162 0 0.13 0.016
ssr5_human 113 3.26x26 TM3 R => H missense 4.196e-05 5 119150 0 0.02 1.0
ssr5_human 114 3.27x27 TM3 L => M missense 8.393e-06 1 119152 0 0.05 0.964
ssr5_human 116 3.29x29 TM3 M => V missense 8.396e-06 1 119110 0 0.0 0.438
ssr5_human 117 3.30x30 TM3 T => M missense 0.00121 144 119020 0 0.0 0.984
ssr5_human 120 3.33x33 TM3 G => S missense 1.681e-05 2 118970 0 0.37 1.0
ssr5_human 121 3.34x34 TM3 V => I missense 4.204e-05 5 118946 0 1.0 0.015
ssr5_human 134 3.47x47 TM3 S => R missense 0.0001099 13 118340 0 0.0 1.0
ssr5_human 135 3.48x48 TM3 V => M missense 7.608e-05 9 118296 0 0.07 0.404
ssr5_human 137 3.50x50 TM3 R => C missense 4.235e-05 5 118056 0 0.01 1.0 SodiumPocket MicroSwitch GP (contact)
ssr5_human 137 3.50x50 TM3 R => S missense 8.471e-06 1 118056 0 0.0 0.999 SodiumPocket MicroSwitch GP (contact)
ssr5_human 137 3.50x50 TM3 R => H missense 4.236e-05 5 118026 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
ssr5_human 138 3.51x51 TM3 Y => H missense 1.696e-05 2 117958 0 0.0 0.999
ssr5_human 140 3.53x53 TM3 A => V missense 2.554e-05 3 117448 0 0.0 0.999 GP (contact)
ssr5_human 141 3.54x54 TM3 V => A missense 0.0002473 29 117258 0 0.0 0.771 GP (contact)
ssr5_human 142 3.55x55 TM3 V => M missense 8.542e-06 1 117068 0 0.0 1.0 GP (contact)
ssr5_human 143 3.56x56 TM3 H => Q missense 8.602e-06 1 116252 0 0.0 0.762 GP (contact)
ssr5_human 144 34.50x50 ICL2 P => L missense 2.603e-05 3 115270 0 0.01 1.0 GP (contact)
ssr5_human 144 34.50x50 ICL2 P => Q missense 8.675e-06 1 115270 0 0.0 1.0 GP (contact)
ssr5_human 146 34.52x52 ICL2 S => R missense 8.796e-06 1 113690 0 1.0 0.001 PTM (Phosphorylation) GP (contact)
ssr5_human 149 34.55x55 ICL2 R => C missense 3.605e-05 4 110968 0 0.0 0.912 GP (contact)
ssr5_human 149 34.55x55 ICL2 R => H missense 0.0001983 22 110928 0 0.01 0.04 GP (contact)
ssr5_human 151 34.57x57 ICL2 R => C missense 9.234e-06 1 108298 0 0.0 1.0 GP (contact)
ssr5_human 152 4.38x38 TM4 R => C missense 9.245e-06 1 108168 0 0.0 0.984
ssr5_human 152 4.38x38 TM4 R => H missense 3.72e-05 4 107528 0 0.06 0.967
ssr5_human 153 4.39x39 TM4 P => L missense 1.858e-05 2 107664 0 0.01 1.0
ssr5_human 154 4.40x40 TM4 R => C missense 9.299e-06 1 107542 0 0.0 0.941
ssr5_human 154 4.40x40 TM4 R => H missense 1.87e-05 2 106924 0 0.07 0.041
ssr5_human 159 4.45x45 TM4 A => V missense 1.024e-05 1 97638 0 1.0 0.463
ssr5_human 160 4.46x46 TM4 S => N missense 1.026e-05 1 97436 0 1.0 0.998
ssr5_human 161 4.47x47 TM4 A => S missense 2.086e-05 2 95868 0 0.21 0.999
ssr5_human 162 4.48x48 TM4 A => V missense 0.0001478 14 94694 1 0.04 0.69
ssr5_human 163 4.49x49 TM4 A => P missense 1.056e-05 1 94684 0 0.0 0.659
ssr5_human 163 4.49x49 TM4 A => S missense 1.056e-05 1 94684 0 0.0 0.307
ssr5_human 170 4.56x56 TM4 M => V missense 2.17e-05 2 92176 0 1.0 0.034
ssr5_human 178 4.64x65 TM4 A => T missense 1.111e-05 1 90030 0 0.02 0.699
ssr5_human 178 4.64x65 TM4 A => V missense 3.344e-05 3 89722 0 0.02 0.167
ssr5_human 180 ECL2 V => M missense 3.31e-05 3 90622 0 0.0 0.949
ssr5_human 183 ECL2 G => D missense 1.085e-05 1 92138 0 0.26 0.988
ssr5_human 184 ECL2 G => S missense 4.338e-05 4 92202 0 0.7 0.355
ssr5_human 188 45.52x52 ECL2 A => T missense 2.121e-05 2 94282 0 0.0 0.004
ssr5_human 194 5.31x32 TM5 V => M missense 3.036e-05 3 98798 0 0.07 0.944
ssr5_human 196 5.33x34 TM5 L => P missense 2.978e-05 3 100722 0 0.05 0.968
ssr5_human 196 5.33x34 TM5 L => R missense 9.928e-06 1 100722 0 0.33 0.139
ssr5_human 198 5.35x36 TM5 G => R missense 9.838e-06 1 101650 0 0.49 0.055
ssr5_human 198 5.35x36 TM5 G => D missense 9.819e-06 1 101842 0 0.18 0.645
ssr5_human 199 5.36x37 TM5 A => T missense 4.892e-05 5 102198 0 0.67 0.999
ssr5_human 200 5.37x38 TM5 V => I missense 0.0002023 21 103814 0 0.06 0.024
ssr5_human 203 5.40x41 TM5 I => V missense 1.885e-05 2 106114 0 0.64 0.014
ssr5_human 207 5.44x45 TM5 V => M missense 1.833e-05 2 109134 0 0.08 0.99
ssr5_human 210 5.47x47 TM5 F => L missense 8.994e-06 1 111186 0 0.0 0.997 SodiumPocket MicroSwitch
ssr5_human 212 5.49x49 TM5 A => T missense 3.558e-05 4 112410 0 0.29 0.386
ssr5_human 212 5.49x49 TM5 A => V missense 9.777e-05 11 112504 0 0.46 0.465
ssr5_human 213 5.50x50 TM5 P => L missense 2.654e-05 3 113030 0 0.0 1.0 SodiumPocket MicroSwitch
ssr5_human 220 5.57x57 TM5 C => G missense 8.666e-06 1 115396 0 0.0 0.998
ssr5_human 223 5.60x60 TM5 L => F missense 8.639e-06 1 115754 0 0.08 1.0
ssr5_human 224 5.61x61 TM5 I => L missense 8.629e-06 1 115888 0 0.06 0.991 GP (contact)
ssr5_human 224 5.61x61 TM5 I => M missense 8.632e-06 1 115852 0 0.02 0.999 GP (contact)
ssr5_human 226 5.63x63 TM5 V => A missense 1.723e-05 2 116058 0 0.21 0.015
ssr5_human 229 5.66x66 TM5 R => W missense 8.628e-06 1 115902 0 0.02 0.955 GP (contact)
ssr5_human 230 5.67x67 TM5 A => V missense 6.921e-05 8 115592 0 0.08 0.066 GP (contact)
ssr5_human 230 5.67x67 TM5 A => E missense 8.651e-06 1 115592 0 0.0 0.891 GP (contact)
ssr5_human 231 5.68x68 TM5 A => V missense 2.602e-05 3 115298 0 0.38 0.016 GP (contact)
ssr5_human 231 5.68x68 TM5 A => G missense 1.735e-05 2 115298 0 0.43 0.388 GP (contact)
ssr5_human 233 ICL3 V => M missense 8.647e-06 1 115650 0 0.2 0.079
ssr5_human 234 ICL3 R => C missense 2.592e-05 3 115736 0 0.0 0.999
ssr5_human 234 ICL3 R => H missense 8.64e-06 1 115736 0 0.0 0.999
ssr5_human 235 ICL3 V => M missense 8.622e-05 10 115986 0 0.01 0.833
ssr5_human 238 6.25x25 TM6 V => M missense 0.0001374 16 116408 0 0.08 0.015 GP (contact)
ssr5_human 239 6.26x26 TM6 R => G missense 3.438e-05 4 116342 0 0.0 0.055 GP (contact)
ssr5_human 239 6.26x26 TM6 R => W missense 1.719e-05 2 116342 0 0.0 0.979 GP (contact)
ssr5_human 239 6.26x26 TM6 R => Q missense 4.29e-05 5 116554 0 0.06 0.874 GP (contact)
ssr5_human 240 6.27x27 TM6 R => W missense 0.001664 194 116554 0 0.0 1.0
ssr5_human 240 6.27x27 TM6 R => Q missense 8.565e-06 1 116748 0 0.0 0.998
ssr5_human 241 6.28x28 TM6 R => C missense 1.712e-05 2 116814 0 0.0 0.999 GP (contact)
ssr5_human 241 6.28x28 TM6 R => L missense 1.711e-05 2 116918 0 0.02 0.999 GP (contact)
ssr5_human 241 6.28x28 TM6 R => H missense 8.553e-06 1 116918 0 0.03 0.999 GP (contact)
ssr5_human 242 6.29x29 TM6 S => L missense 1.708e-05 2 117122 0 0.0 0.667 PTM (Phosphorylation) GP (contact)
ssr5_human 242 6.29x29 TM6 S => W missense 8.538e-06 1 117122 0 0.01 0.99 PTM (Phosphorylation) GP (contact)
ssr5_human 244 6.31x31 TM6 R => G missense 8.514e-06 1 117456 0 0.07 0.871
ssr5_human 244 6.31x31 TM6 R => W missense 8.514e-06 1 117456 0 0.0 0.983
ssr5_human 244 6.31x31 TM6 R => Q missense 2.552e-05 3 117564 0 0.02 0.898
ssr5_human 244 6.31x31 TM6 R => L missense 8.506e-06 1 117564 0 0.0 0.871
ssr5_human 247 6.34x34 TM6 T => A missense 8.472e-06 1 118036 0 0.0 0.997 SodiumPocket MicroSwitch PTM (Phosphorylation)
ssr5_human 247 6.34x34 TM6 T => M missense 2.542e-05 3 118024 0 0.0 0.999 SodiumPocket MicroSwitch PTM (Phosphorylation)
ssr5_human 248 6.35x35 TM6 R => C missense 0.001532 181 118148 1 0.01 0.999
ssr5_human 248 6.35x35 TM6 R => H missense 2.538e-05 3 118208 0 0.03 0.999
ssr5_human 250 6.37x37 TM6 V => M missense 3.376e-05 4 118498 0 0.0 0.999 GP (contact)
ssr5_human 251 6.38x38 TM6 L => S missense 0.002782 330 118638 6 0.27 0.397
ssr5_human 258 6.45x45 TM6 A => V missense 8.402e-06 1 119024 0 1.0 0.007
ssr5_human 260 6.47x47 TM6 C => Y missense 8.385e-06 1 119266 0 0.0 0.999
ssr5_human 263 6.50x50 TM6 P => L missense 5.025e-05 6 119412 0 0.0 1.0 SodiumPocket MicroSwitch
ssr5_human 267 6.54x54 TM6 V => I missense 8.369e-06 1 119488 0 0.24 0.011
ssr5_human 270 6.57x57 TM6 V => I missense 8.364e-05 10 119558 0 0.2 0.095
ssr5_human 273 6.60x60 TM6 A => S missense 1.672e-05 2 119594 0 0.24 0.938
ssr5_human 274 6.61x61 TM6 V => M missense 0.0001254 15 119606 0 0.16 0.709
ssr5_human 278 ECL3 Q => K missense 8.361e-06 1 119602 0 0.19 0.036
ssr5_human 279 7.28x27 TM7 E => K missense 0.0004849 58 119618 1 0.18 0.997
ssr5_human 281 7.30x29 TM7 A => T missense 3.348e-05 4 119490 0 0.49 0.028
ssr5_human 283 7.32x31 TM7 A => T missense 2.513e-05 3 119380 0 0.5 0.022
ssr5_human 286 7.35x34 TM7 Y => C missense 8.35e-05 10 119758 0 0.01 0.999
ssr5_human 287 7.36x35 TM7 F => V missense 8.349e-06 1 119768 0 0.34 0.09
ssr5_human 288 7.37x36 TM7 F => L missense 8.349e-06 1 119778 0 0.49 0.41
ssr5_human 295 7.44x43 TM7 A => T missense 8.349e-06 1 119768 0 0.02 0.999 SodiumPocket MicroSwitch
ssr5_human 296 7.45x45 TM7 N => T missense 2.505e-05 3 119770 0 0.0 0.998
ssr5_human 297 7.46x46 TM7 S => G missense 8.35e-06 1 119766 0 0.0 0.994
ssr5_human 298 7.47x47 TM7 C => Y missense 8.352e-06 1 119736 0 0.0 0.999
ssr5_human 298 7.47x47 TM7 C => F missense 8.352e-06 1 119736 0 0.0 0.999
ssr5_human 301 7.50x50 TM7 P => T missense 8.354e-06 1 119704 0 0.0 1.0 SodiumPocket MicroSwitch
ssr5_human 302 7.51x51 TM7 V => I missense 0.0001755 21 119654 0 1.0 0.016
ssr5_human 305 7.54x54 TM7 G => S missense 4.183e-05 5 119534 0 0.05 0.999
ssr5_human 306 7.55x55 TM7 F => L missense 1.673e-05 2 119512 0 0.06 0.978 GP (contact)
ssr5_human 312 8.51x51 H8 R => C missense 5.874e-05 7 119168 0 0.0 0.997 GP (contact)
ssr5_human 312 8.51x51 H8 R => H missense 1.679e-05 2 119124 0 0.02 0.997 GP (contact)
ssr5_human 312 8.51x51 H8 R => L missense 8.395e-06 1 119124 0 0.0 0.997 GP (contact)
ssr5_human 318 8.57x57 H8 V => F missense 3.369e-05 4 118730 0 0.0 0.527
ssr5_human 322 C-term R => C missense 8.449e-06 1 118358 0 0.04 0.014
ssr5_human 322 C-term R => L missense 1.69e-05 2 118312 0 0.04 0.252
ssr5_human 322 C-term R => H missense 1.69e-05 2 118312 0 0.16 0.014
ssr5_human 324 C-term G => D missense 8.462e-06 1 118172 0 0.62 0.558
ssr5_human 327 C-term A => V missense 0.0001527 18 117888 0 1.0 0.002
ssr5_human 330 C-term A => T missense 5.107e-05 6 117484 0 0.26 0.336
ssr5_human 331 C-term D => Y missense 8.524e-06 1 117322 0 0.0 0.808
ssr5_human 331 C-term D => E missense 8.54e-06 1 117096 0 0.86 0.021
ssr5_human 332 C-term A => T missense 8.551e-06 1 116942 0 0.56 0.003
ssr5_human 333 C-term T => M missense 0.007813 911 116602 24 0.12 0.014 PTM (Phosphorylation)
ssr5_human 335 C-term P => L missense 0.5386 62255 115580 17132 0.12 0.041
ssr5_human 336 C-term R => C missense 8.807e-06 1 113540 0 0.02 0.781
ssr5_human 336 C-term R => H missense 8.817e-05 10 113416 0 0.03 0.636
ssr5_human 341 C-term R => W missense 0.0001338 15 112124 0 0.01 0.409
ssr5_human 341 C-term R => Q missense 2.683e-05 3 111812 0 0.46 0.045
ssr5_human 342 C-term Q => K missense 8.936e-06 1 111908 0 0.82 0.013
ssr5_human 345 C-term E => Q missense 9.041e-06 1 110606 0 0.22 0.008
ssr5_human 345 C-term E => D missense 9.118e-06 1 109670 0 0.45 0.058
ssr5_human 346 C-term A => V missense 2.761e-05 3 108670 0 0.23 0.003
ssr5_human 347 C-term T => R missense 9.2e-06 1 108694 0 0.44 0.343 PTM (Phosphorylation)
ssr5_human 348 C-term P => L missense 3.688e-05 4 108468 0 0.5 0.0
ssr5_human 349 C-term P => R missense 1.119e-05 1 89364 0 0.14 0.549
ssr5_human 350 C-term A => T missense 0.000101 9 89100 0 1.0 0.002
ssr5_human 352 C-term R => C missense 3.493e-05 3 85890 0 0.07 0.015
ssr5_human 352 C-term R => H missense 2.329e-05 2 85884 0 0.13 0.003
ssr5_human 353 C-term A => T missense 0.0001534 13 84734 0 0.89 0.038
ssr5_human 354 C-term A => T missense 7.267e-05 6 82570 0 0.57 0.001
ssr5_human 356 C-term N => H missense 9.836e-05 8 81338 0 0.0 0.694
ssr5_human 357 C-term G => R missense 0.00195 156 79982 0 0.03 0.066
ssr5_human 357 C-term G => A missense 1.258e-05 1 79516 0 0.0 0.354
ssr5_human 358 C-term L => P missense 1.27e-05 1 78734 0 0.26 0.003
ssr5_human 360 C-term Q => R missense 0.0002756 21 76206 0 0.0 0.5
ssr5_human 364 C-term L => P missense 5.579e-05 4 71698 0 nan 0.863


Residue

Diagrams

ICL1 A K M K ICL1ECL1 S F W P F ECL1ICL2 P L S S A R W R ICL2ECL2 D V Q E G G T C N A S W P E P ECL2ICL3 V R V ICL3ECL3 A L P Q ECL3N-term M E P L F P A S T P S W N A S S P G A A S G G G D N R T L V G P A P S A N-termC-term L R K G S G A K D A D A T E P R P D R I R Q Q Q E A T P P A H R A A A N G L M Q T S K L C-term G A R A V L V P V L Y L L V C A A G L G G N T L V I Y V V L R F T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H R P R V A K L A S A A A W V L S L C M S L P L L V F A V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G G C V R R R S E R K V T R M V L V V V L V F A G C W L P F F T V N I V N L A V E P A S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F Q K F R Q S V L C
SnakePlot Download: PNG | SVG T N G G L G A A C V L L Y L V P V L V A 1 L N L A V A D V L Y M L G L P F L A T Q 2 V T L C F V S T F Q N V G D L T M V L R 3 A K L A S A A A W V L S L C M S L P L 4 Y C L C I V L L P A F F G L V A T Y I I F 5 L V V V L V F A G C W L P F F T V N I V 6 V P N A C S N A Y S L I V V F F Y L G 7
HelixBox Download: PNG | SVG