5-HT2B receptor (5ht2b_drome)
FAMILY
Class A (Rhodopsin) Aminergic receptors 5-Hydroxytryptamine receptors 5-HT2B receptor
GENE
5-HT1B (5HT-R2B, CG15113)
ORGANISM
Fruit fly (Drosophila melanogaster)
ALT. NAMES
5-hydroxytryptamine receptor 2B, 5-HT receptor 2B, 5-hydroxytryptamine receptor 1B, 5-HT receptor 1B, Serotonin receptor 1B, Serotonin receptor 2B
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
L
|
K
|
T
|
V
|
T
|
T
|
A
|
M
|
A
|
10 |
A
|
G
|
D
|
D
|
D
|
V
|
P
|
A
|
S
|
I
|
20 |
L
|
E
|
I
|
E
|
L
|
P
|
A
|
I
|
L
|
L
|
30 |
N
|
E
|
S
|
L
|
F
|
I
|
E
|
L
|
N
|
G
|
40 |
N
|
L
|
T
|
Q
|
L
|
V
|
D
|
T
|
T
|
S
|
50 |
N
|
L
|
S
|
Q
|
I
|
V
|
W
|
N
|
R
|
S
|
60 |
I
|
N
|
G
|
N
|
G
|
N
|
S
|
N
|
T
|
F
|
70 |
D
|
L
|
V
|
D
|
D
|
E
|
Q
|
E
|
R
|
A
|
80 |
A
|
V
|
E
|
F
|
W
|
L
|
L
|
V
|
K
|
M
|
90 |
TM1 | |||||||||
I
|
A
|
M
|
A
|
V
|
V
|
L
|
G
|
L
|
M
|
100 |
I
|
L
|
V
|
T
|
I
|
I
|
G
|
N
|
V
|
F
|
110 |
V
|
I
|
A
|
A
|
I
|
I
|
L
|
E
|
R
|
N
|
120 |
ICL1 | TM2 | ||||||||
L
|
Q
|
N
|
V
|
A
|
N
|
Y
|
L
|
V
|
A
|
130 |
S
|
L
|
A
|
V
|
A
|
D
|
L
|
F
|
V
|
A
|
140 |
C
|
L
|
V
|
M
|
P
|
L
|
G
|
A
|
V
|
Y
|
150 |
ECL1 | |||||||||
E
|
I
|
S
|
N
|
G
|
W
|
I
|
L
|
G
|
P
|
160 |
TM3 | |||||||||
E
|
L
|
C
|
D
|
I
|
W
|
T
|
S
|
C
|
D
|
170 |
V
|
L
|
C
|
C
|
T
|
A
|
S
|
I
|
L
|
H
|
180 |
L
|
V
|
A
|
I
|
A
|
A
|
D
|
R
|
Y
|
W
|
190 |
ICL2 | |||||||||
T
|
V
|
T
|
N
|
I
|
D
|
Y
|
N
|
N
|
L
|
200 |
TM4 | |||||||||
R
|
T
|
P
|
R
|
R
|
V
|
F
|
L
|
M
|
I
|
210 |
F
|
C
|
V
|
W
|
F
|
A
|
A
|
L
|
I
|
V
|
220 |
S
|
L
|
A
|
P
|
Q
|
F
|
G
|
W
|
K
|
D
|
230 |
ECL2 | |||||||||
P
|
D
|
Y
|
M
|
K
|
R
|
I
|
E
|
E
|
Q
|
240 |
TM5 | |||||||||
H
|
C
|
M
|
V
|
S
|
Q
|
D
|
V
|
G
|
Y
|
250 |
Q
|
I
|
F
|
A
|
T
|
C
|
C
|
T
|
F
|
Y
|
260 |
V
|
P
|
L
|
L
|
V
|
I
|
L
|
F
|
L
|
Y
|
270 |
W
|
K
|
I
|
Y
|
I
|
I
|
A
|
R
|
K
|
R
|
280 |
I
|
Q
|
R
|
R
|
A
|
Q
|
K
|
S
|
F
|
N
|
290 |
ICL3 | |||||||||
V
|
T
|
L
|
T
|
E
|
T
|
D
|
C
|
D
|
S
|
300 |
A
|
V
|
R
|
E
|
L
|
K
|
K
|
E
|
R
|
S
|
310 |
K
|
R
|
R
|
A
|
E
|
R
|
K
|
R
|
L
|
E
|
320 |
A
|
G
|
E
|
R
|
T
|
P
|
V
|
D
|
G
|
D
|
330 |
G
|
T
|
G
|
G
|
Q
|
L
|
Q
|
R
|
R
|
T
|
340 |
R
|
K
|
R
|
M
|
R
|
I
|
C
|
F
|
G
|
R
|
350 |
N
|
T
|
N
|
T
|
A
|
N
|
V
|
V
|
A
|
G
|
360 |
S
|
E
|
G
|
A
|
V
|
A
|
R
|
S
|
M
|
A
|
370 |
A
|
I
|
A
|
V
|
D
|
F
|
A
|
S
|
L
|
A
|
380 |
I
|
T
|
R
|
E
|
E
|
T
|
E
|
F
|
S
|
T
|
390 |
S
|
N
|
Y
|
D
|
N
|
K
|
S
|
H
|
A
|
G
|
400 |
T
|
E
|
L
|
T
|
T
|
V
|
S
|
S
|
D
|
A
|
410 |
D
|
D
|
Y
|
R
|
T
|
S
|
N
|
A
|
N
|
E
|
420 |
I
|
I
|
T
|
L
|
S
|
Q
|
Q
|
V
|
A
|
H
|
430 |
A
|
T
|
Q
|
H
|
H
|
L
|
I
|
A
|
S
|
H
|
440 |
L
|
N
|
A
|
I
|
T
|
P
|
L
|
A
|
Q
|
S
|
450 |
I
|
A
|
M
|
G
|
G
|
V
|
G
|
C
|
L
|
T
|
460 |
T
|
T
|
T
|
P
|
S
|
E
|
K
|
A
|
L
|
S
|
470 |
G
|
A
|
G
|
T
|
V
|
A
|
G
|
A
|
V
|
A
|
480 |
G
|
G
|
S
|
G
|
S
|
G
|
S
|
G
|
E
|
E
|
490 |
G
|
A
|
G
|
T
|
E
|
G
|
K
|
N
|
A
|
G
|
500 |
V
|
G
|
L
|
G
|
G
|
V
|
L
|
A
|
S
|
I
|
510 |
A
|
N
|
P
|
H
|
Q
|
K
|
L
|
A
|
K
|
R
|
520 |
TM6 | |||||||||
R
|
Q
|
L
|
L
|
E
|
A
|
K
|
R
|
E
|
R
|
530 |
K
|
A
|
A
|
Q
|
T
|
L
|
A
|
I
|
I
|
T
|
540 |
G
|
A
|
F
|
V
|
I
|
C
|
W
|
L
|
P
|
F
|
550 |
F
|
V
|
M
|
A
|
L
|
T
|
M
|
S
|
L
|
C
|
560 |
ECL3 | TM7 | ||||||||
K
|
E
|
C
|
E
|
I
|
H
|
T
|
A
|
V
|
A
|
570 |
S
|
L
|
F
|
L
|
W
|
L
|
G
|
Y
|
F
|
N
|
580 |
S
|
T
|
L
|
N
|
P
|
V
|
I
|
Y
|
T
|
I
|
590 |
H8 | |||||||||
F
|
N
|
P
|
E
|
F
|
R
|
R
|
A
|
F
|
K
|
600 |
C-term | |||||||||
R
|
I
|
L
|
F
|
G
|
R
|
K
|
A
|
A
|
A
|
610 |
R
|
A
|
R
|
S
|
A
|
K
|
I
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
No endogenous ligands available
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available