FPR2/ALX (fpr2_mouse)

FAMILY

Class A (Rhodopsin) Peptide receptors Formylpeptide receptors FPR2/ALX

GENE

Fpr2 (Fpr-rs2)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Formyl peptide receptor 2, Formylpeptide receptor-related sequence 2, Lipoxin A4 receptor-like protein, N-formylpeptide receptor-like 2

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
E
S
N
Y
S
I
H
L
N
10
                   
G
S
E
V
V
V
Y
D
S
T
20
TM1              
I
S
R
V
L
W
I
L
S
M
30
                   
V
V
V
S
I
T
F
F
L
G
40
                   
V
L
G
N
G
L
V
I
W
V
50
          ICL1 TM2
A
G
F
R
M
P
H
T
V
T
60
               
T
I
W
Y
L
N
L
A
L
A
70
                   
D
F
S
F
T
A
T
L
P
F
80
                   
L
L
V
E
M
A
M
K
E
K
90
ECL1 TM3      
W
P
F
G
W
F
L
C
K
L
100
                   
V
H
I
V
V
D
V
N
L
F
110
                   
G
S
V
F
L
I
A
L
I
A
120
                   
L
D
R
C
I
C
V
L
H
P
130
ICL2       TM4
V
W
A
Q
N
H
R
T
V
S
140
                   
L
A
R
K
V
V
V
G
P
W
150
                   
I
F
A
L
I
L
T
L
P
I
160
        ECL2    
F
I
F
L
T
T
V
R
I
P
170
                   
G
G
D
V
Y
C
T
F
N
F
180
          TM5    
G
S
W
A
Q
T
D
E
E
K
190
                   
L
N
T
A
I
T
F
V
T
T
200
                   
R
G
I
I
R
F
L
I
G
F
210
                   
S
M
P
M
S
I
V
A
V
C
220
                   
Y
G
L
I
A
V
K
I
N
R
230
    ICL3 TM6  
R
N
L
V
N
S
S
R
P
L
240
                   
R
V
L
T
A
V
V
A
S
F
250
                   
F
I
C
W
F
P
F
Q
L
V
260
                   
A
L
L
G
T
V
W
F
K
E
270
ECL3     TM7  
T
L
L
S
G
S
Y
K
I
L
280
                   
D
M
F
V
N
P
T
S
S
L
290
                   
A
Y
F
N
S
C
L
N
P
M
300
          H8      
L
Y
V
F
M
G
Q
D
F
R
310
                   
E
R
F
I
H
S
L
P
Y
S
320
C-term        
L
E
R
A
L
S
E
D
S
G
330
                   
Q
T
S
D
S
S
T
S
S
T
340
                   
S
P
P
A
D
I
E
L
K
A
350
 
P

LINKS

DIAGRAMS

G N G L V G L F F T I S V V V M S L I W 1 L N L A L A D F S F T A T L P F L L V E 2 L A I L F V S G F L N V D V V I H V L K 3 A R K V V V G P W I F A L I L T L P I 4 Y C V A V I S M P M S F G I L F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F Y A L S S T P N V F M 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

ICL1 P H ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V R I P G G D V Y C T F N F G S W A Q ECL2ICL3 L V N S ICL3ECL3 F K E T L L S G S ECL3N-term M E S N Y S I H L N G S E V V V Y D N-termC-term P Y S L E R A L S E D S G Q T S D S S T S S T S P P A D I E L K A P C-term S T I S R V L W I L S M V V V S I T F F L G V L G N G L V I W V A G F R M T V T T I W Y L N L A L A D F S F T A T L P F L L V E M A M K G W F L C K L V H I V V D V N L F G S V F L I A L I A L D R C I C V L H T V S L A R K V V V G P W I F A L I L T L P I F I F L T D E E K L N T A I T F V T T R G I I R F L I G F S M P M S I V A V C Y G L I A V K I N R R N S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I L D M F V N P T S S L A Y F N S C L N P M L Y V F M G Q D F I H F R E R S L
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

annexin I,

humanin,

LL-37,

serum amyloid A,

PrP106-126,

CRAMP,

LXA4,

aspirin triggered lipoxin A4,

resolvin D1,

aspirin-triggered resolvin D1

HOMOLOGY MODELS

No homology models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available