BLT2 receptor (lt4r2_rat)

FAMILY

Class A (Rhodopsin) Lipid receptors Leukotriene receptors BLT2 receptor

GENE

Ltb4r2

ORGANISM

Rat (Rattus norvegicus)

ALT. NAMES

Leukotriene B4 receptor 2, LTB4-R 2, LTB4-R2, LTB4 receptor JULF2

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
S
V
C
Y
R
P
P
G
N
10
        TM1      
E
T
L
L
S
W
K
G
S
R
20
                   
A
T
G
T
A
F
L
L
L
A
30
                   
A
L
L
G
L
P
G
N
G
F
40
                   
V
V
W
S
L
A
G
W
R
P
50
ICL1 TM2      
T
A
G
R
P
L
A
A
T
L
60
                   
V
L
H
L
A
L
A
D
G
A
70
                   
V
L
L
L
T
P
L
F
V
A
80
          ECL1  
F
L
S
R
Q
A
W
P
L
G
90
TM3              
Q
V
G
C
K
A
V
Y
Y
V
100
                   
C
A
L
S
M
Y
A
S
V
L
110
                   
L
T
G
L
L
S
L
Q
R
C
120
          ICL2  
L
A
V
T
R
P
F
L
A
P
130
      TM4        
R
L
R
S
P
A
L
A
R
R
140
                   
L
L
L
G
V
W
L
A
A
L
150
                   
V
L
A
V
P
A
A
V
Y
R
160
ECL2            
H
L
W
G
D
R
V
C
Q
L
170
              TM5
C
H
P
S
A
V
H
A
A
A
180
                   
H
L
S
L
E
T
L
T
A
F
190
                   
V
L
P
F
G
T
V
L
G
C
200
                   
Y
G
V
T
L
A
R
L
R
G
210
ICL3 TM6      
A
R
W
G
S
G
R
Q
G
T
220
                   
R
V
G
R
L
V
S
A
I
V
230
                   
L
A
F
G
L
L
W
A
P
Y
240
                   
H
A
V
N
L
L
Q
A
V
A
250
      ECL3      
A
L
A
P
P
E
G
P
L
A
260
  TM7            
R
L
G
G
A
G
Q
A
A
R
270
                   
A
G
T
T
A
L
A
F
F
S
280
                   
S
S
V
N
P
V
L
Y
V
F
290
                   
T
A
G
D
L
L
P
R
A
G
300
C-term        
P
R
F
L
T
R
L
F
E
G
310
                   
S
G
E
A
R
V
G
S
R
S
320
                   
R
E
G
T
M
E
L
R
T
T
330
                   
P
R
L
K
V
V
G
Q
G
R
340
                   
G
Y
G
D
P
G
G
G
G
R
350
               
M
E
K
D
S
Q
E
W

LINKS

DIAGRAMS

G N G P L G L L A A L L L F A T G T A R 1 L H L A L A D G A V L L L T P L F V A F 2 L G T L L V S A Y M S L A C V Y Y V A K 3 A R R L L L G V W L A A L V L A V P A 4 Y C G L V T G F P L V F A T L T E L S L H 5 S A I V L A F G L L W A P Y H A V N L L 6 V P N V S S S F F A L A T T G A R A A 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

ICL1 R P T A ICL1ECL1 A W P L ECL1ICL2 P F L A P R L R ICL2ECL2 H L W G D R V C Q L C H P S A V H ECL2ICL3 A R W G ICL3ECL3 P P E G P L A R ECL3N-term M S V C Y R P P G N E T L L N-termC-term G P R F L T R L F E G S G E A R V G S R S R E G T M E L R T T P R L K V V G Q G R G Y G D P G G G G R M E K D S Q E W C-term S W K G S R A T G T A F L L L A A L L G L P G N G F V V W S L A G W G R P L A A T L V L H L A L A D G A V L L L T P L F V A F L S R Q G Q V G C K A V Y Y V C A L S M Y A S V L L T G L L S L Q R C L A V T R S P A L A R R L L L G V W L A A L V L A V P A A V Y R A A A H L S L E T L T A F V L P F G T V L G C Y G V T L A R L R G S G R Q G T R V G R L V S A I V L A F G L L W A P Y H A V N L L Q A V A A L A L G G A G Q A A R A G T T A L A F F S S S V N P V L Y V F T A G D L L P R A
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

20-hydroxy-LTB4,

12R-HETE,

LTB4,

12-epi LTB4,

15S-HETE,

12S-HETE,

12S-HPETE,

12-hydroxyheptadecatrienoic acid

HOMOLOGY MODELS

No homology models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available