MC1 receptor (mshr_vulla)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC1 receptor

GENE

MC1R

ORGANISM

Arctic fox (Vulpes lagopus)

ALT. NAMES

Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
S
G
Q
G
P
Q
R
R
L
10
                   
L
G
S
L
N
A
T
S
P
T
20
                   
T
P
H
F
K
L
A
A
N
Q
30
                   
T
G
P
R
C
L
E
V
S
I
40
TM1              
P
D
G
L
F
L
S
L
G
L
50
                   
V
S
V
V
E
N
V
L
V
V
60
            ICL1
A
A
I
A
K
N
R
N
L
H
70
TM2              
S
P
M
Y
Y
F
I
G
C
L
80
                   
A
V
S
D
L
L
V
S
V
T
90
                   
N
V
L
E
T
A
V
M
L
L
100
        ECL1    
V
E
A
G
A
L
A
A
Q
A
110
TM3              
A
V
V
Q
Q
L
D
D
I
I
120
                   
D
V
L
I
C
G
S
M
V
S
130
                   
S
L
C
F
L
G
A
I
A
V
140
                   
D
R
Y
L
S
I
F
Y
A
L
150
ICL2     TM4  
R
Y
H
S
I
V
T
L
P
R
160
                   
A
W
R
A
I
S
A
I
W
V
170
                   
A
S
V
L
S
S
T
L
F
I
180
    ECL2 TM5  
A
Y
Y
N
H
T
A
V
L
L
190
                   
C
L
V
S
F
F
V
A
M
L
200
                   
V
L
M
A
V
L
Y
V
H
M
210
                   
L
A
R
A
R
Q
H
A
R
G
220
            ICL3
I
A
R
L
R
K
R
Q
H
S
230
    TM6          
V
H
Q
G
F
G
L
K
G
A
240
                   
A
T
L
T
I
L
L
G
I
F
250
                   
F
L
C
W
G
P
F
F
L
H
260
                   
L
S
L
M
V
L
C
P
Q
H
270
ECL3            
P
I
C
G
C
V
F
Q
N
F
280
TM7              
N
L
F
L
T
L
I
I
C
N
290
                   
S
I
I
D
P
F
I
Y
A
F
300
  H8              
R
S
Q
E
L
R
K
T
L
Q
310
C-term  
E
V
V
L
C
S
W

LINKS

DIAGRAMS

ICL1 R N L H ICL1ECL1 A L A A ECL1ICL2 A L R Y H S I V ICL2ECL2 Y N ECL2ICL3 R Q H S V H ICL3ECL3 P Q H P I C G C V F Q ECL3N-term M S G Q G P Q R R L L G S L N A T S P T T P H F K L A A N Q T G P R C L E V S I N-termC-term L Q E V V L C S W C-term P D G L F L S L G L V S V V E N V L V V A A I A K N S P M Y Y F I G C L A V S D L L V S V T N V L E T A V M L L V E A G Q A A V V Q Q L D D I I D V L I C G S M V S S L C F L G A I A V D R Y L S I F Y T L P R A W R A I S A I W V A S V L S S T L F I A Y H T A V L L C L V S F F V A M L V L M A V L Y V H M L A R A R Q H A R G I A R L R K Q G F G L K G A A T L T I L L G I F F L C W G P F F L H L S L M V L C N F N L F L T L I I C N S I I D P F I Y A F R S Q E L R K T
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

V N E V V S V L G L S L F L G D P 1 G C L A V S D L L V S V T N V L E T A V 2 A G L F C L S S V M S G C I L V D I I D 3 A W R A I S A I W V A S V L S S T L F I 4 Y L V A M L V L M A V F F S V L C L L V 5 T I L L G I F F L C W G P F F L H L S L 6 F P D I I S N C I I L T L F L N F N 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available