y6 receptor (npy6r_human)

FAMILY

Class A (Rhodopsin) Peptide receptors Neuropeptide Y receptors y6 receptor

GENE

NPY6R (NPY1RL, Y2B)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Putative neuropeptide Y receptor type 6, NPY6-R, NPY Y1-like receptor, Putative pancreatic polypeptide receptor 2, PP2

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
E
V
S
L
N
H
P
A
S
10
                   
N
T
T
S
T
K
N
N
N
S
20
                   
A
F
F
Y
F
E
S
C
Q
P
30
TM1              
P
S
P
A
L
L
L
L
C
I
40
                   
A
Y
T
V
V
L
I
V
G
L
50
                   
F
G
N
L
S
L
I
I
I
I
60
      ICL1      
F
K
K
Q
R
K
A
Q
N
F
70
TM2              
T
S
I
L
I
A
N
L
S
L
80
                   
S
D
T
L
V
C
V
M
C
I
90
                   
H
F
T
I
I
Y
T
L
M
D
100
ECL1 TM3      
H
W
I
F
G
D
T
M
C
R
110
                   
L
T
S
Y
V
Q
S
V
S
I
120
                   
S
V
S
I
F
S
L
V
F
T
130
                   
A
V
E
R
Y
Q
L
I
V
N
140
ICL2     TM4  
P
R
G
W
K
P
S
V
T
H
150
                   
A
Y
W
G
I
T
L
I
W
L
160
                   
F
S
L
L
L
S
I
P
F
F
170
      ECL2      
L
S
Y
H
L
T
D
E
P
F
180
                   
R
N
L
S
L
P
T
D
L
Y
190
                   
T
H
Q
V
A
C
V
E
N
W
200
  TM5            
P
S
K
K
D
R
L
L
F
T
210
                   
T
S
L
F
L
L
Q
Y
F
V
220
                   
P
L
G
F
I
L
I
C
Y
L
230
                   
K
I
V
I
C
L
R
R
R
N
240
        ICL3 TM6
A
K
V
D
K
K
K
E
N
E
250
                 
G
R
L
N
E
N
K
R
I
N
260
                   
T
M
L
I
S
I
V
V
T
F
270
                   
G
A
C
W
L
P
R
I
S
S
280
                   
M
S
S
L
T
G
I
M
R
C
290

LINKS

DIAGRAMS

L N G F L G V I L V V T Y A I C L L L L 1 A N L S L S D T L V C V M C I H F T I I 2 F V L S F I S V S I S V S Q V Y S T L R 3 A Y W G I T L I W L F S L L L S I P F 4 Y C I L I F G L P V F Y Q L L F L S T T F 5 I S I V V T F G A C W L P R I S S M S S 6
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

ICL1 R Q K A Q ICL1ECL1 H W I F ECL1ICL2 P R G W K P ICL2ECL2 H L T D E P F R N L S L P T D L Y T H Q V A C V E N W P ECL2ICL3 K K K ICL3N-term M E V S L N H P A S N T T S T K N N N S A F F Y F E S C Q P N-termC-term M R C C-term P S P A L L L L C I A Y T V V L I V G L F G N L S L I I I I F K K N F T S I L I A N L S L S D T L V C V M C I H F T I I Y T L M D G D T M C R L T S Y V Q S V S I S V S I F S L V F T A V E R Y Q L I V N S V T H A Y W G I T L I W L F S L L L S I P F F L S Y S K K D R L L F T T S L F L L Q Y F V P L G F I L I C Y L K I V I C L R R R N A K V D E N E G R L N E N K R I N T M L I S I V V T F G A C W L P R I S S M S S L T G I
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

No endogenous ligands available

HOMOLOGY MODELS

No homology models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available