TAS2R14 (tr123_rat)

FAMILY

Class T (Taste 2) Sensory receptors Taste 2 receptors TAS2R14

GENE

Tas2r123 (Tas2r14, Tas2r2, Tas2r23)

ORGANISM

Rat (Rattus norvegicus)

ALT. NAMES

Taste receptor type 2 member 123, T2R123, Taste receptor type 2 member 2, T2R2, Taste receptor type 2 member 23, T2R23

SOURCE

SWISSPROT

SEQUENCE

N-term TM1  
M
F
S
Q
K
T
N
Y
S
H
10
                   
L
F
T
F
S
I
I
F
Y
V
20
                   
E
I
V
T
G
I
L
G
N
G
30
                   
F
I
A
L
V
N
I
M
D
W
40
        ICL1 TM2
L
K
R
R
R
I
S
T
A
D
50
                 
Q
I
L
T
A
L
A
L
T
R
60
                   
L
I
Y
V
W
S
V
L
I
C
70
                   
I
L
L
L
F
L
C
P
H
L
80
ECL1 TM3      
S
M
R
P
E
M
F
T
A
I
90
                   
G
V
I
W
V
V
D
N
H
F
100
                   
S
I
W
L
A
T
C
L
G
V
110
                   
F
Y
F
L
K
I
A
S
F
S
120
ICL2            
N
S
L
F
L
Y
L
K
W
R
130
TM4              
V
K
K
V
V
L
M
I
I
L
140
                   
I
S
L
I
F
L
M
L
N
I
150
                   
S
S
L
G
M
Y
D
H
F
S
160
ECL2            
I
D
V
Y
E
G
N
M
S
Y
170
                   
N
L
V
D
S
T
H
F
P
R
180
                   
I
F
L
F
T
N
S
S
K
V
190
                   
F
L
I
A
N
S
S
H
V
F
200
TM5              
L
P
I
N
S
L
F
M
L
I
210
                   
P
F
T
V
S
L
V
A
F
F
220
                   
V
L
F
L
S
L
W
K
H
H
230
                   
K
K
M
Q
V
N
A
K
G
P
240
ICL3 TM6      
R
D
A
S
T
M
A
H
T
K
250
                   
A
L
Q
I
G
F
S
F
L
L
260
                   
L
Y
A
I
Y
L
L
F
I
I
270
                   
T
G
I
L
N
L
D
L
M
R
280
ECL3 TM7      
C
I
V
I
L
L
F
D
H
I
290
                   
S
G
A
V
F
S
I
S
H
S
300
            H8    
F
V
L
I
L
G
N
S
K
L
310
                   
R
Q
A
T
L
S
V
L
P
C
320
                   
L
R
C
R
S
K
D
M
D
T
330
C-term
V
V
F

LINKS

UniProt

DIAGRAMS

ICL1 R I ICL1ECL1 P H L S M ECL1ICL2 S F S N S L F L Y L K W ICL2ECL2 F S I D V Y E G N M S Y N L V D S T H F P R I F L F T N S S K V F L I A N S S H V ECL2ICL3 K G P R ICL3ECL3 M R C ECL3N-term M F S Q K T N-termC-term M D T V V F C-term N Y S H L F T F S I I F Y V E I V T G I L G N G F I A L V N I M D W L K R R S T A D Q I L T A L A L T R L I Y V W S V L I C I L L L F L C R P E M F T A I G V I W V V D N H F S I W L A T C L G V F Y F L K I A R V K K V V L M I I L I S L I F L M L N I S S L G M Y D H F L P I N S L F M L I P F T V S L V A F F V L F L S L W K H H K K M Q V N A D A S T M A H T K A L Q I G F S F L L L Y A I Y L L F I I T G I L N L D L I V I L L F D H I S G A V F S I S H S F V L I L G N S K T L S L R C L R Q A V L P C R S K D
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N G L I G T V I E V Y F I I S F T F L 1 T A L A L T R L I Y V W S V L I C I L L 2 C T A L W I S F H N D V V W I V G I A T 3 V L M I I L I S L I F L M L N I S S L G 4 F A V L S V T F P I L M F L S N I P L F 5 G F S F L L L Y A I Y L L F I I T G I L 6 F S H S I S F V A G S I H D F L L I V 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

1 mutation data points available.

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available