apelin receptor (apj_mouse)
FAMILY
Class A (Rhodopsin) Peptide receptors Apelin receptors apelin receptor
GENE
Aplnr (Agtrl1, Apj)
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, MSR
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
E
|
D
|
D
|
G
|
Y
|
N
|
Y
|
Y
|
G
|
10 |
A
|
D
|
N
|
Q
|
S
|
E
|
C
|
D
|
Y
|
A
|
20 |
TM1 | |||||||||
D
|
W
|
K
|
P
|
S
|
G
|
A
|
L
|
I
|
P
|
30 |
A
|
I
|
Y
|
M
|
L
|
V
|
F
|
L
|
L
|
G
|
40 |
T
|
T
|
G
|
N
|
G
|
L
|
V
|
L
|
W
|
T
|
50 |
ICL1 | |||||||||
V
|
F
|
R
|
T
|
S
|
R
|
E
|
K
|
R
|
R
|
60 |
TM2 | |||||||||
S
|
A
|
D
|
I
|
F
|
I
|
A
|
S
|
L
|
A
|
70 |
V
|
A
|
D
|
L
|
T
|
F
|
V
|
V
|
T
|
L
|
80 |
P
|
L
|
W
|
A
|
T
|
Y
|
T
|
Y
|
R
|
E
|
90 |
ECL1 | TM3 | ||||||||
F
|
D
|
W
|
P
|
F
|
G
|
T
|
F
|
S
|
C
|
100 |
K
|
L
|
S
|
S
|
Y
|
L
|
I
|
F
|
V
|
N
|
110 |
M
|
Y
|
A
|
S
|
V
|
F
|
C
|
L
|
T
|
G
|
120 |
L
|
S
|
F
|
D
|
R
|
Y
|
L
|
A
|
I
|
V
|
130 |
ICL2 | |||||||||
R
|
P
|
V
|
A
|
N
|
A
|
R
|
L
|
R
|
L
|
140 |
TM4 | |||||||||
R
|
V
|
S
|
G
|
A
|
V
|
A
|
T
|
A
|
V
|
150 |
L
|
W
|
V
|
L
|
A
|
A
|
L
|
L
|
A
|
V
|
160 |
ECL2 | |||||||||
P
|
V
|
M
|
V
|
F
|
R
|
S
|
T
|
D
|
A
|
170 |
S
|
E
|
N
|
G
|
T
|
K
|
I
|
Q
|
C
|
Y
|
180 |
M
|
D
|
Y
|
S
|
M
|
V
|
A
|
T
|
S
|
N
|
190 |
TM5 | |||||||||
S
|
E
|
W
|
A
|
W
|
E
|
V
|
G
|
L
|
G
|
200 |
V
|
S
|
S
|
T
|
A
|
V
|
G
|
F
|
V
|
V
|
210 |
P
|
F
|
T
|
I
|
M
|
L
|
T
|
C
|
Y
|
F
|
220 |
F
|
I
|
A
|
Q
|
T
|
I
|
A
|
G
|
H
|
F
|
230 |
ICL3 | TM6 | ||||||||
R
|
K
|
E
|
R
|
I
|
E
|
G
|
L
|
R
|
K
|
240 |
R
|
R
|
R
|
L
|
L
|
S
|
I
|
I
|
V
|
V
|
250 |
L
|
V
|
V
|
T
|
F
|
A
|
L
|
C
|
W
|
M
|
260 |
P
|
Y
|
H
|
L
|
V
|
K
|
T
|
L
|
Y
|
M
|
270 |
ECL3 | TM7 | |||||||||
L
|
G
|
S
|
L
|
L
|
H
|
W
|
P
|
C
|
D
|
|
280 |
F
|
D
|
I
|
F
|
L
|
M
|
N
|
V
|
F
|
P
|
290 |
Y
|
C
|
T
|
C
|
I
|
S
|
Y
|
V
|
N
|
S
|
300 |
C
|
L
|
N
|
P
|
F
|
L
|
Y
|
A
|
F
|
F
|
310 |
H8 | |||||||||
D
|
P
|
R
|
F
|
R
|
Q
|
A
|
C
|
T
|
S
|
320 |
M
|
L
|
C
|
C
|
D
|
Q
|
S
|
G
|
C
|
K
|
330 |
C-term | |||||||||
G
|
T
|
P
|
H
|
S
|
S
|
S
|
A
|
E
|
K
|
340 |
S
|
A
|
S
|
Y
|
S
|
S
|
G
|
H
|
S
|
Q
|
350 |
G
|
P
|
G
|
P
|
N
|
M
|
G
|
K
|
G
|
G
|
360 |
E
|
Q
|
M
|
H
|
E
|
K
|
S
|
I
|
P
|
Y
|
370 |
S
|
Q
|
E
|
T
|
L
|
V
|
D
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
No endogenous ligands available
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available