GnRH1 receptor (gnrhr_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Gonadotrophin-releasing hormone receptors GnRH1 receptor
GENE
GNRHR (GRHR)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
N
|
S
|
A
|
S
|
P
|
E
|
Q
|
N
|
10 |
Q
|
N
|
H
|
C
|
S
|
A
|
I
|
N
|
N
|
S
|
20 |
I
|
P
|
L
|
M
|
Q
|
G
|
N
|
L
|
P
|
T
|
30 |
TM1 | |||||||||
L
|
T
|
L
|
S
|
G
|
K
|
I
|
R
|
V
|
T
|
40 |
V
|
T
|
F
|
F
|
L
|
F
|
L
|
L
|
S
|
A
|
50 |
T
|
F
|
N
|
A
|
S
|
F
|
L
|
L
|
K
|
L
|
60 |
ICL1 | |||||||||
Q
|
K
|
W
|
T
|
Q
|
K
|
K
|
E
|
K
|
G
|
70 |
TM2 | |||||||||
K
|
K
|
L
|
S
|
R
|
M
|
K
|
L
|
L
|
L
|
80 |
K
|
H
|
L
|
T
|
L
|
A
|
N
|
L
|
L
|
E
|
90 |
T
|
L
|
I
|
V
|
M
|
P
|
L
|
D
|
G
|
M
|
100 |
ECL1 | |||||||||
W
|
N
|
I
|
T
|
V
|
Q
|
W
|
Y
|
A
|
G
|
110 |
TM3 | |||||||||
E
|
L
|
L
|
C
|
K
|
V
|
L
|
S
|
Y
|
L
|
120 |
K
|
L
|
F
|
S
|
M
|
Y
|
A
|
P
|
A
|
F
|
130 |
M
|
M
|
V
|
V
|
I
|
S
|
L
|
D
|
R
|
S
|
140 |
ICL2 | |||||||||
L
|
A
|
I
|
T
|
R
|
P
|
L
|
A
|
L
|
K
|
150 |
TM4 | |||||||||
S
|
N
|
S
|
K
|
V
|
G
|
Q
|
S
|
M
|
V
|
160 |
G
|
L
|
A
|
W
|
I
|
L
|
S
|
S
|
V
|
F
|
170 |
A
|
G
|
P
|
Q
|
L
|
Y
|
I
|
F
|
R
|
M
|
180 |
ECL2 | |||||||||
I
|
H
|
L
|
A
|
D
|
S
|
S
|
G
|
Q
|
T
|
190 |
K
|
V
|
F
|
S
|
Q
|
C
|
V
|
T
|
H
|
C
|
200 |
TM5 | |||||||||
S
|
F
|
S
|
Q
|
W
|
W
|
H
|
Q
|
A
|
F
|
210 |
Y
|
N
|
F
|
F
|
T
|
F
|
S
|
C
|
L
|
F
|
220 |
I
|
I
|
P
|
L
|
F
|
I
|
M
|
L
|
I
|
C
|
230 |
N
|
A
|
K
|
I
|
I
|
F
|
T
|
L
|
T
|
R
|
240 |
V
|
L
|
H
|
Q
|
D
|
P
|
H
|
E
|
L
|
Q
|
250 |
ICL3 | TM6 | ||||||||
L
|
N
|
Q
|
S
|
K
|
N
|
N
|
I
|
P
|
R
|
260 |
A
|
R
|
L
|
K
|
T
|
L
|
K
|
M
|
T
|
V
|
270 |
A
|
F
|
A
|
T
|
S
|
F
|
T
|
V
|
C
|
W
|
280 |
T
|
P
|
Y
|
Y
|
V
|
L
|
G
|
I
|
W
|
Y
|
290 |
ECL3 | |||||||||
W
|
F
|
D
|
P
|
E
|
M
|
L
|
N
|
R
|
L
|
300 |
TM7 | |||||||||
S
|
D
|
P
|
V
|
N
|
H
|
F
|
F
|
F
|
L
|
310 |
F
|
A
|
F
|
L
|
N
|
P
|
C
|
F
|
D
|
P
|
320 |
L
|
I
|
Y
|
G
|
Y
|
F
|
S
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
GnRH I, GnRH II
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 7BR3