GPR88 (gpr88_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR88
GENE
GPR88 (STRG)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Probable G-protein coupled receptor 88, Striatum-specific G-protein coupled receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
T
|
N
|
S
|
S
|
S
|
T
|
S
|
T
|
S
|
10 |
S
|
T
|
T
|
G
|
G
|
S
|
L
|
L
|
L
|
L
|
20 |
TM1 | |||||||||
C
|
E
|
E
|
E
|
E
|
S
|
W
|
A
|
G
|
R
|
30 |
R
|
I
|
P
|
V
|
S
|
L
|
L
|
Y
|
S
|
G
|
40 |
L
|
A
|
I
|
G
|
G
|
T
|
L
|
A
|
N
|
G
|
50 |
M
|
V
|
I
|
Y
|
L
|
V
|
S
|
S
|
F
|
R
|
60 |
ICL1 | TM2 | ||||||||
K
|
L
|
Q
|
T
|
T
|
S
|
N
|
A
|
F
|
I
|
70 |
V
|
N
|
G
|
C
|
A
|
A
|
D
|
L
|
S
|
V
|
80 |
C
|
A
|
L
|
W
|
M
|
P
|
Q
|
E
|
A
|
V
|
90 |
ECL1 | |||||||||
L
|
G
|
L
|
L
|
P
|
T
|
G
|
S
|
A
|
E
|
100 |
TM3 | |||||||||
P
|
P
|
A
|
D
|
W
|
D
|
G
|
A
|
G
|
G
|
110 |
S
|
Y
|
R
|
L
|
L
|
R
|
G
|
G
|
L
|
L
|
120 |
G
|
L
|
G
|
L
|
T
|
V
|
S
|
L
|
L
|
S
|
130 |
H
|
C
|
L
|
V
|
A
|
L
|
N
|
R
|
Y
|
L
|
140 |
ICL2 | |||||||||
L
|
I
|
T
|
R
|
A
|
P
|
A
|
T
|
Y
|
Q
|
150 |
TM4 | |||||||||
A
|
L
|
Y
|
Q
|
R
|
R
|
H
|
T
|
A
|
G
|
160 |
M
|
L
|
A
|
L
|
S
|
W
|
A
|
L
|
A
|
L
|
170 |
ECL2 | |||||||||
G
|
L
|
V
|
L
|
L
|
L
|
P
|
P
|
W
|
A
|
180 |
P
|
R
|
P
|
G
|
A
|
A
|
P
|
P
|
R
|
V
|
190 |
TM5 | |||||||||
H
|
Y
|
P
|
A
|
L
|
L
|
A
|
A
|
A
|
A
|
200 |
L
|
L
|
A
|
Q
|
T
|
A
|
L
|
L
|
L
|
H
|
210 |
C
|
Y
|
L
|
G
|
I
|
V
|
R
|
R
|
V
|
R
|
220 |
V
|
S
|
V
|
K
|
R
|
V
|
S
|
V
|
L
|
N
|
230 |
ICL3 | |||||||||
F
|
H
|
L
|
L
|
H
|
Q
|
L
|
P
|
G
|
C
|
240 |
A
|
A
|
A
|
A
|
A
|
A
|
F
|
P
|
G
|
A
|
250 |
Q
|
H
|
A
|
P
|
G
|
P
|
G
|
G
|
A
|
A
|
260 |
H
|
P
|
A
|
Q
|
A
|
Q
|
P
|
L
|
P
|
P
|
270 |
A
|
L
|
H
|
P
|
R
|
R
|
A
|
Q
|
R
|
R
|
280 |
TM6 | |||||||||
L
|
S
|
G
|
L
|
S
|
V
|
L
|
L
|
L
|
C
|
290 |
C
|
V
|
F
|
L
|
L
|
A
|
T
|
Q
|
P
|
L
|
300 |
V
|
W
|
V
|
S
|
L
|
A
|
S
|
G
|
F
|
S
|
310 |
ECL3 | TM7 | ||||||||
L
|
P
|
V
|
P
|
W
|
G
|
V
|
Q
|
A
|
A
|
320 |
S
|
W
|
L
|
L
|
C
|
C
|
A
|
L
|
S
|
A
|
330 |
L
|
N
|
P
|
L
|
L
|
Y
|
T
|
W
|
R
|
N
|
340 |
H8 | |||||||||
E
|
E
|
F
|
R
|
R
|
S
|
V
|
R
|
S
|
V
|
350 |
C-term | |||||||||
L
|
P
|
G
|
V
|
G
|
D
|
A
|
A
|
A
|
A
|
360 |
A
|
V
|
A
|
A
|
T
|
A
|
V
|
P
|
A
|
V
|
370 |
S
|
Q
|
A
|
Q
|
L
|
G
|
T
|
R
|
A
|
A
|
380 |
G
|
Q
|
H
|
W
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
No endogenous ligands available
STRUCTURE MODELS
STRUCTURES
Found 2 structure(s) - view all details on the Structures page