H1 receptor (hrh1_rat)
FAMILY
Class A (Rhodopsin) Aminergic receptors Histamine receptors H1 receptor
GENE
Hrh1
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
Histamine H1 receptor, H1R, HH1R
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
F
|
A
|
N
|
T
|
S
|
S
|
T
|
F
|
10 |
E
|
D
|
K
|
M
|
C
|
E
|
G
|
N
|
R
|
T
|
20 |
A
|
M
|
A
|
S
|
P
|
Q
|
L
|
L
|
P
|
L
|
30 |
TM1 | |||||||||
V
|
V
|
V
|
L
|
S
|
S
|
I
|
S
|
L
|
V
|
40 |
T
|
V
|
G
|
L
|
N
|
L
|
L
|
V
|
L
|
Y
|
50 |
ICL1 | |||||||||
A
|
V
|
H
|
S
|
E
|
R
|
K
|
L
|
H
|
T
|
60 |
TM2 | |||||||||
V
|
G
|
N
|
L
|
Y
|
I
|
V
|
S
|
L
|
S
|
70 |
V
|
A
|
D
|
L
|
I
|
V
|
G
|
A
|
V
|
V
|
80 |
M
|
P
|
M
|
N
|
I
|
L
|
Y
|
L
|
I
|
M
|
90 |
ECL1 | TM3 | ||||||||
T
|
K
|
W
|
S
|
L
|
G
|
R
|
P
|
L
|
C
|
100 |
L
|
F
|
W
|
L
|
S
|
M
|
D
|
Y
|
V
|
A
|
110 |
S
|
T
|
A
|
S
|
I
|
F
|
S
|
V
|
F
|
I
|
120 |
L
|
C
|
I
|
D
|
R
|
Y
|
R
|
S
|
V
|
Q
|
130 |
ICL2 | |||||||||
Q
|
P
|
L
|
R
|
Y
|
L
|
R
|
Y
|
R
|
T
|
140 |
TM4 | |||||||||
K
|
T
|
R
|
A
|
S
|
A
|
T
|
I
|
L
|
G
|
150 |
A
|
W
|
F
|
F
|
S
|
F
|
L
|
W
|
V
|
I
|
160 |
ECL2 | |||||||||
P
|
I
|
L
|
G
|
W
|
H
|
H
|
F
|
M
|
P
|
170 |
P
|
A
|
P
|
E
|
L
|
R
|
E
|
D
|
K
|
C
|
180 |
TM5 | |||||||||
E
|
T
|
D
|
F
|
Y
|
N
|
V
|
T
|
W
|
F
|
190 |
K
|
I
|
M
|
T
|
A
|
I
|
I
|
N
|
F
|
Y
|
200 |
L
|
P
|
T
|
L
|
L
|
M
|
L
|
W
|
F
|
Y
|
210 |
V
|
K
|
I
|
Y
|
K
|
A
|
V
|
R
|
R
|
H
|
220 |
C
|
Q
|
H
|
R
|
Q
|
L
|
T
|
N
|
G
|
S
|
230 |
ICL3 | |||||||||
L
|
P
|
S
|
F
|
S
|
E
|
L
|
K
|
L
|
R
|
240 |
S
|
D
|
D
|
T
|
K
|
E
|
G
|
A
|
K
|
K
|
250 |
P
|
G
|
R
|
E
|
S
|
P
|
W
|
G
|
V
|
L
|
260 |
K
|
R
|
P
|
S
|
R
|
D
|
P
|
S
|
V
|
G
|
270 |
L
|
D
|
Q
|
K
|
S
|
T
|
S
|
E
|
D
|
P
|
280 |
K
|
M
|
T
|
S
|
P
|
T
|
V
|
F
|
S
|
Q
|
290 |
E
|
G
|
E
|
R
|
E
|
T
|
R
|
P
|
C
|
F
|
300 |
R
|
L
|
D
|
I
|
M
|
Q
|
K
|
Q
|
S
|
V
|
310 |
A
|
E
|
G
|
D
|
V
|
R
|
G
|
S
|
K
|
A
|
320 |
N
|
D
|
Q
|
A
|
L
|
S
|
Q
|
P
|
K
|
M
|
330 |
D
|
E
|
Q
|
S
|
L
|
N
|
T
|
C
|
R
|
R
|
340 |
I
|
S
|
E
|
T
|
S
|
E
|
D
|
Q
|
T
|
L
|
350 |
V
|
D
|
Q
|
Q
|
S
|
F
|
S
|
R
|
T
|
T
|
360 |
D
|
S
|
D
|
T
|
S
|
I
|
E
|
P
|
G
|
P
|
370 |
G
|
R
|
V
|
K
|
S
|
R
|
S
|
G
|
S
|
N
|
380 |
S
|
G
|
L
|
D
|
Y
|
I
|
K
|
I
|
T
|
W
|
390 |
K
|
R
|
L
|
R
|
S
|
H
|
S
|
R
|
Q
|
Y
|
400 |
TM6 | |||||||||
V
|
S
|
G
|
L
|
H
|
L
|
N
|
R
|
E
|
R
|
410 |
K
|
A
|
A
|
K
|
Q
|
L
|
G
|
F
|
I
|
M
|
420 |
A
|
A
|
F
|
I
|
L
|
C
|
W
|
I
|
P
|
Y
|
430 |
F
|
I
|
F
|
F
|
M
|
V
|
I
|
A
|
F
|
C
|
440 |
ECL3 | TM7 | ||||||||
K
|
S
|
C
|
C
|
S
|
E
|
P
|
M
|
H
|
M
|
450 |
F
|
T
|
I
|
W
|
L
|
G
|
Y
|
I
|
N
|
S
|
460 |
T
|
L
|
N
|
P
|
L
|
I
|
Y
|
P
|
L
|
C
|
470 |
H8 | |||||||||
N
|
E
|
N
|
F
|
K
|
K
|
T
|
F
|
K
|
K
|
480 |
C-term | ||||||||
I
|
L
|
H
|
I
|
R
|
S
|
|||
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
No endogenous ligands available
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available