MRGPRE (mrgre_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans MRGPRE
GENE
MRGPRE (GPR167, MRGE)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Mas-related G-protein coupled receptor member E, G-protein coupled receptor 167
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
M
|
E
|
P
|
R
|
E
|
A
|
G
|
Q
|
H
|
10 |
V
|
G
|
A
|
A
|
N
|
G
|
A
|
Q
|
E
|
D
|
20 |
TM1 | |||||||||
V
|
A
|
F
|
N
|
L
|
I
|
I
|
L
|
S
|
L
|
30 |
T
|
E
|
G
|
L
|
G
|
L
|
G
|
G
|
L
|
L
|
40 |
G
|
N
|
G
|
A
|
V
|
L
|
W
|
L
|
L
|
S
|
50 |
ICL1 | TM2 | ||||||||
S
|
N
|
V
|
Y
|
R
|
N
|
P
|
F
|
A
|
I
|
60 |
Y
|
L
|
L
|
D
|
V
|
A
|
C
|
A
|
D
|
L
|
70 |
I
|
F
|
L
|
G
|
C
|
H
|
M
|
V
|
A
|
I
|
80 |
ECL1 | |||||||||
V
|
P
|
D
|
L
|
L
|
Q
|
G
|
R
|
L
|
D
|
90 |
TM3 | |||||||||
F
|
P
|
G
|
F
|
V
|
Q
|
T
|
S
|
L
|
A
|
100 |
T
|
L
|
R
|
F
|
F
|
C
|
Y
|
I
|
V
|
G
|
110 |
L
|
S
|
L
|
L
|
A
|
A
|
V
|
S
|
V
|
E
|
120 |
Q
|
C
|
L
|
A
|
A
|
L
|
F
|
P
|
A
|
W
|
130 |
ICL2 | TM4 | ||||||||
Y
|
S
|
C
|
R
|
R
|
P
|
R
|
H
|
L
|
T
|
140 |
T
|
C
|
V
|
C
|
A
|
L
|
T
|
W
|
A
|
L
|
150 |
C
|
L
|
L
|
L
|
H
|
L
|
L
|
L
|
S
|
G
|
160 |
ECL2 | |||||||||
A
|
C
|
T
|
Q
|
F
|
F
|
G
|
E
|
P
|
S
|
170 |
TM5 | |||||||||
R
|
H
|
L
|
C
|
R
|
T
|
L
|
W
|
L
|
V
|
180 |
A
|
A
|
V
|
L
|
L
|
A
|
L
|
L
|
C
|
C
|
190 |
T
|
M
|
C
|
G
|
A
|
S
|
L
|
M
|
L
|
L
|
200 |
L
|
R
|
V
|
E
|
R
|
G
|
P
|
Q
|
R
|
P
|
210 |
ICL3 | TM6 | ||||||||
P
|
P
|
R
|
G
|
F
|
P
|
G
|
L
|
I
|
L
|
220 |
L
|
T
|
V
|
L
|
L
|
F
|
L
|
F
|
C
|
G
|
230 |
L
|
P
|
F
|
G
|
I
|
Y
|
W
|
L
|
S
|
R
|
240 |
ECL3 | TM7 | ||||||||
N
|
L
|
L
|
W
|
Y
|
I
|
P
|
H
|
Y
|
F
|
250 |
Y
|
H
|
F
|
S
|
F
|
L
|
M
|
A
|
A
|
V
|
260 |
H
|
C
|
A
|
A
|
K
|
P
|
V
|
V
|
Y
|
F
|
270 |
H8 | |||||||||
C
|
L
|
G
|
S
|
A
|
Q
|
G
|
R
|
R
|
L
|
280 |
P
|
L
|
R
|
L
|
V
|
L
|
Q
|
R
|
A
|
L
|
290 |
C-term | |||||||||
G
|
D
|
E
|
A
|
E
|
L
|
G
|
A
|
V
|
R
|
300 |
E
|
T
|
S
|
R
|
R
|
G
|
L
|
V
|
D
|
I
|
310 |
A
|
A
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
No endogenous ligands available
STRUCTURE MODELS
STRUCTURES
No structures available