Y5 receptor (npy5r_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Neuropeptide Y receptors Y5 receptor
GENE
NPY5R (NPYR5)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Neuropeptide Y receptor type 5, NPY5-R, NPY-Y5 receptor, NPYY5-R, Y5 receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
L
|
E
|
L
|
D
|
E
|
Y
|
Y
|
N
|
10 |
K
|
T
|
L
|
A
|
T
|
E
|
N
|
N
|
T
|
A
|
20 |
A
|
T
|
R
|
N
|
S
|
D
|
F
|
P
|
V
|
W
|
30 |
D
|
D
|
Y
|
K
|
S
|
S
|
V
|
D
|
D
|
L
|
40 |
TM1 | |||||||||
Q
|
Y
|
F
|
L
|
I
|
G
|
L
|
Y
|
T
|
F
|
50 |
V
|
S
|
L
|
L
|
G
|
F
|
M
|
G
|
N
|
L
|
60 |
L
|
I
|
L
|
M
|
A
|
L
|
M
|
K
|
K
|
R
|
70 |
ICL1 | TM2 | ||||||||
N
|
Q
|
K
|
T
|
T
|
V
|
N
|
F
|
L
|
I
|
80 |
G
|
N
|
L
|
A
|
F
|
S
|
D
|
I
|
L
|
V
|
90 |
V
|
L
|
F
|
C
|
S
|
P
|
F
|
T
|
L
|
T
|
100 |
ECL1 | |||||||||
S
|
V
|
L
|
L
|
D
|
Q
|
W
|
M
|
F
|
G
|
110 |
TM3 | |||||||||
K
|
V
|
M
|
C
|
H
|
I
|
M
|
P
|
F
|
L
|
120 |
Q
|
C
|
V
|
S
|
V
|
L
|
V
|
S
|
T
|
L
|
130 |
I
|
L
|
I
|
S
|
I
|
A
|
I
|
V
|
R
|
Y
|
140 |
ICL2 | |||||||||
H
|
M
|
I
|
K
|
H
|
P
|
I
|
S
|
N
|
N
|
150 |
TM4 | |||||||||
L
|
T
|
A
|
N
|
H
|
G
|
Y
|
F
|
L
|
I
|
160 |
A
|
T
|
V
|
W
|
T
|
L
|
G
|
F
|
A
|
I
|
170 |
C
|
S
|
P
|
L
|
P
|
V
|
F
|
H
|
S
|
L
|
180 |
ECL2 | |||||||||
V
|
E
|
L
|
Q
|
E
|
T
|
F
|
G
|
S
|
A
|
190 |
L
|
L
|
S
|
S
|
R
|
Y
|
L
|
C
|
V
|
E
|
200 |
TM5 | |||||||||
S
|
W
|
P
|
S
|
D
|
S
|
Y
|
R
|
I
|
A
|
210 |
F
|
T
|
I
|
S
|
L
|
L
|
L
|
V
|
Q
|
Y
|
220 |
I
|
L
|
P
|
L
|
V
|
C
|
L
|
T
|
V
|
S
|
230 |
H
|
T
|
S
|
V
|
C
|
R
|
S
|
I
|
S
|
C
|
240 |
G
|
L
|
S
|
N
|
K
|
E
|
N
|
R
|
L
|
E
|
250 |
ICL3 | |||||||||
E
|
N
|
E
|
M
|
I
|
N
|
L
|
T
|
L
|
H
|
260 |
P
|
S
|
K
|
K
|
S
|
G
|
P
|
Q
|
V
|
K
|
270 |
L
|
S
|
G
|
S
|
H
|
K
|
W
|
S
|
Y
|
S
|
280 |
F
|
I
|
K
|
K
|
H
|
R
|
R
|
R
|
Y
|
S
|
290 |
K
|
K
|
T
|
A
|
C
|
V
|
L
|
P
|
A
|
P
|
300 |
E
|
R
|
P
|
S
|
Q
|
E
|
N
|
H
|
S
|
R
|
310 |
I
|
L
|
P
|
E
|
N
|
F
|
G
|
S
|
V
|
R
|
320 |
S
|
Q
|
L
|
S
|
S
|
S
|
S
|
K
|
F
|
I
|
330 |
P
|
G
|
V
|
P
|
T
|
C
|
F
|
E
|
I
|
K
|
340 |
P
|
E
|
E
|
N
|
S
|
D
|
V
|
H
|
E
|
L
|
350 |
TM6 | |||||||||
R
|
V
|
K
|
R
|
S
|
V
|
T
|
R
|
I
|
K
|
360 |
K
|
R
|
S
|
R
|
S
|
V
|
F
|
Y
|
R
|
L
|
370 |
T
|
I
|
L
|
I
|
L
|
V
|
F
|
A
|
V
|
S
|
380 |
W
|
M
|
P
|
L
|
H
|
L
|
F
|
H
|
V
|
V
|
390 |
ECL3 | |||||||||
T
|
D
|
F
|
N
|
D
|
N
|
L
|
I
|
S
|
N
|
400 |
TM7 | |||||||||
R
|
H
|
F
|
K
|
L
|
V
|
Y
|
C
|
I
|
C
|
410 |
H
|
L
|
L
|
G
|
M
|
M
|
S
|
C
|
C
|
L
|
420 |
H8 | |||||||||
N
|
P
|
I
|
L
|
Y
|
G
|
F
|
L
|
N
|
N
|
430 |
G
|
I
|
K
|
A
|
D
|
L
|
V
|
S
|
L
|
I
|
440 |
H
|
C
|
L
|
H
|
M
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
peptide YY, neuropeptide Y, PYY-(3-36), pancreatic polypeptide
STRUCTURE MODELS
STRUCTURES
No structures available