Rhodopsin (opsd_todpa)
FAMILY
Class A (Rhodopsin) Sensory receptors Opsins Rhodopsin
GENE
RHO
ORGANISM
Japanese flying squid (Todarodes pacificus)
ALT. NAMES
Rhodopsin
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
G
|
R
|
D
|
L
|
R
|
D
|
N
|
E
|
T
|
10 |
W
|
W
|
Y
|
N
|
P
|
S
|
I
|
V
|
V
|
H
|
20 |
P
|
H
|
W
|
R
|
E
|
F
|
D
|
Q
|
V
|
P
|
30 |
TM1 | |||||||||
D
|
A
|
V
|
Y
|
Y
|
S
|
L
|
G
|
I
|
F
|
40 |
I
|
G
|
I
|
C
|
G
|
I
|
I
|
G
|
C
|
G
|
50 |
G
|
N
|
G
|
I
|
V
|
I
|
Y
|
L
|
F
|
T
|
60 |
ICL1 | TM2 | ||||||||
K
|
T
|
K
|
S
|
L
|
Q
|
T
|
P
|
A
|
N
|
70 |
M
|
F
|
I
|
I
|
N
|
L
|
A
|
F
|
S
|
D
|
80 |
F
|
T
|
F
|
S
|
L
|
V
|
N
|
G
|
F
|
P
|
90 |
L
|
M
|
T
|
I
|
S
|
C
|
F
|
L
|
K
|
K
|
100 |
ECL1 | TM3 | ||||||||
W
|
I
|
F
|
G
|
F
|
A
|
A
|
C
|
K
|
V
|
110 |
Y
|
G
|
F
|
I
|
G
|
G
|
I
|
F
|
G
|
F
|
120 |
M
|
S
|
I
|
M
|
T
|
M
|
A
|
M
|
I
|
S
|
130 |
I
|
D
|
R
|
Y
|
N
|
V
|
I
|
G
|
R
|
P
|
140 |
ICL2 | TM4 | ||||||||
M
|
A
|
A
|
S
|
K
|
K
|
M
|
S
|
H
|
R
|
150 |
R
|
A
|
F
|
I
|
M
|
I
|
I
|
F
|
V
|
W
|
160 |
L
|
W
|
S
|
V
|
L
|
W
|
A
|
I
|
G
|
P
|
170 |
ECL2 | |||||||||
I
|
F
|
G
|
W
|
G
|
A
|
Y
|
T
|
L
|
E
|
180 |
G
|
V
|
L
|
C
|
N
|
C
|
S
|
F
|
D
|
Y
|
190 |
TM5 | |||||||||
I
|
S
|
R
|
D
|
S
|
T
|
T
|
R
|
S
|
N
|
200 |
I
|
L
|
C
|
M
|
F
|
I
|
L
|
G
|
F
|
F
|
210 |
G
|
P
|
I
|
L
|
I
|
I
|
F
|
F
|
C
|
Y
|
220 |
F
|
N
|
I
|
V
|
M
|
S
|
V
|
S
|
N
|
H
|
230 |
E
|
K
|
E
|
M
|
A
|
A
|
M
|
A
|
K
|
R
|
240 |
ICL3 | TM6 | ||||||||
L
|
N
|
A
|
K
|
E
|
L
|
R
|
K
|
A
|
Q
|
250 |
A
|
G
|
A
|
N
|
A
|
E
|
M
|
R
|
L
|
A
|
260 |
K
|
I
|
S
|
I
|
V
|
I
|
V
|
S
|
Q
|
F
|
270 |
L
|
L
|
S
|
W
|
S
|
P
|
Y
|
A
|
V
|
V
|
280 |
A
|
L
|
L
|
A
|
Q
|
F
|
G
|
P
|
L
|
E
|
290 |
ECL3 | TM7 | ||||||||
W
|
V
|
T
|
P
|
Y
|
A
|
A
|
Q
|
L
|
P
|
300 |
V
|
M
|
F
|
A
|
K
|
A
|
S
|
A
|
I
|
H
|
310 |
H8 | |||||||||
N
|
P
|
M
|
I
|
Y
|
S
|
V
|
S
|
H
|
P
|
320 |
K
|
F
|
R
|
E
|
A
|
I
|
S
|
Q
|
T
|
F
|
330 |
C-term | |||||||||
P
|
W
|
V
|
L
|
T
|
C
|
C
|
Q
|
F
|
D
|
340 |
D
|
K
|
E
|
T
|
E
|
D
|
D
|
K
|
D
|
A
|
350 |
E
|
T
|
E
|
I
|
P
|
A
|
G
|
E
|
S
|
S
|
360 |
D
|
A
|
A
|
P
|
S
|
A
|
D
|
A
|
A
|
Q
|
370 |
M
|
K
|
E
|
M
|
M
|
A
|
M
|
M
|
Q
|
K
|
380 |
M
|
Q
|
Q
|
Q
|
Q
|
A
|
A
|
Y
|
P
|
P
|
390 |
Q
|
G
|
Y
|
A
|
P
|
P
|
P
|
Q
|
G
|
Y
|
400 |
P
|
P
|
Q
|
G
|
Y
|
P
|
P
|
Q
|
G
|
Y
|
410 |
P
|
P
|
Q
|
G
|
Y
|
P
|
P
|
Q
|
G
|
Y
|
420 |
P
|
P
|
P
|
P
|
Q
|
G
|
A
|
P
|
P
|
Q
|
430 |
G
|
A
|
P
|
P
|
A
|
A
|
P
|
P
|
Q
|
G
|
440 |
V
|
D
|
N
|
Q
|
A
|
Y
|
Q
|
A
|
LINKS
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
No structure models have been generated as experimental structures are available (see below).