EP3 receptor (pe2r3_mouse)

FAMILY

Class A (Rhodopsin) Lipid receptors Prostanoid receptors EP3 receptor

GENE

Ptger3 (Ptgerep3)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Prostaglandin E2 receptor EP3 subtype, PGE receptor EP3 subtype, PGE2 receptor EP3 subtype, Prostanoid EP3 receptor

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
A
S
M
W
A
P
E
H
S
10
                   
A
E
A
H
S
N
L
S
S
T
20
                   
T
D
D
C
G
S
V
S
V
A
30
TM1              
F
P
I
T
M
M
V
T
G
F
40
                   
V
G
N
A
L
A
M
L
L
V
50
          ICL1  
S
R
S
Y
R
R
R
E
S
K
60
  TM2            
R
K
K
S
F
L
L
C
I
G
70
                   
W
L
A
L
T
D
L
V
G
Q
80
                   
L
L
T
S
P
V
V
I
L
V
90
        ECL1    
Y
L
S
Q
R
R
W
E
Q
L
100
      TM3        
D
P
S
G
R
L
C
T
F
F
110
                   
G
L
T
M
T
V
F
G
L
S
120
                   
S
L
L
V
A
S
A
M
A
V
130
                   
E
R
A
L
A
I
R
A
P
H
140
ICL2   TM4    
W
Y
A
S
H
M
K
T
R
A
150
                   
T
P
V
L
L
G
V
W
L
S
160
                   
V
L
A
F
A
L
L
P
V
L
170
  ECL2          
G
V
G
R
Y
S
V
Q
W
P
180
                   
G
T
W
C
F
I
S
T
G
P
190
                   
A
G
N
E
T
D
P
A
R
E
200
TM5              
P
G
S
V
A
F
A
S
A
F
210
                   
A
C
L
G
L
L
A
L
V
V
220
                   
T
F
A
C
N
L
A
T
I
K
230
                   
A
L
V
S
R
C
R
A
K
A
240
ICL3 TM6      
A
V
S
Q
S
S
A
Q
W
G
250
                   
R
I
T
T
E
T
A
I
Q
L
260
                   
M
G
I
M
C
V
L
S
V
C
270
                   
W
S
P
L
L
I
M
M
L
K
280
                   
M
I
F
N
Q
M
S
V
E
Q
290
ECL3 TM7      
C
K
T
Q
M
G
K
E
K
E
300
                   
C
N
S
F
L
I
A
V
R
L
310
                   
A
S
L
N
Q
I
L
D
P
W
320
          H8      
V
Y
L
L
L
R
K
I
L
L
330
                   
R
K
F
C
Q
I
R
D
H
T
340
                   
N
Y
A
S
S
S
T
S
L
P
350
C-term        
C
P
G
S
S
A
L
M
W
S
360
         
D
Q
L
E
R

LINKS

DIAGRAMS

ICL1 R R E S K R ICL1ECL1 R R W E Q L D P S ECL1ICL2 P H W Y A S H ICL2ECL2 V G R Y S V Q W P G T W C F I S T G P A G N E T D P A R E ECL2ICL3 A V S Q ICL3ECL3 V E Q C K ECL3N-term M A S M W A P E H S A E A H S N L S S T T D D C G S V S N-termC-term S T S L P C P G S S A L M W S D Q L E R C-term V A F P I T M M V T G F V G N A L A M L L V S R S Y R K K S F L L C I G W L A L T D L V G Q L L T S P V V I L V Y L S Q G R L C T F F G L T M T V F G L S S L L V A S A M A V E R A L A I R A M K T R A T P V L L G V W L S V L A F A L L P V L G P G S V A F A S A F A C L G L L A L V V T F A C N L A T I K A L V S R C R A K A S S A Q W G R I T T E T A I Q L M G I M C V L S V C W S P L L I M M L K M I F N Q M S T Q M G K E K E C N S F L I A V R L A S L N Q I L D P W V Y L L L R K I F C Q T N Y L L R K I R D H A S S
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

A N G V F G T V M M T I P F A V 1 G W L A L T D L V G Q L L T S P V V I L V 2 A S A V L L S S L G F V T M T L G F F T 3 A T P V L L G V W L S V L A F A L L P V 4 N C A F T V V L A L L G L C A F A S A F 5 M G I M C V L S V C W S P L L I M M L K 6 W P D L I Q N L S A L R V A I L F S N 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

PGE1, PGD2, PGF, PGE2

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available