S1P2 receptor (s1pr2_mouse)

FAMILY

Class A (Rhodopsin) Lipid receptors Lysophospholipid (S1P) receptors S1P2 receptor

GENE

S1pr2 (Edg5, Gpcr13, Lpb2)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Sphingosine 1-phosphate receptor 2, S1P receptor 2, S1P2, Endothelial differentiation G-protein coupled receptor 5, Lysophospholipid receptor B2, Sphingosine 1-phosphate receptor Edg-5, S1P receptor Edg-5

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
G
G
L
Y
S
E
Y
L
N
10
                   
P
E
K
V
L
E
H
Y
N
Y
20
                   
T
K
E
T
L
D
M
Q
E
T
30
TM1              
T
S
R
K
V
A
S
A
F
I
40
                   
I
I
L
C
C
A
I
V
V
E
50
                   
N
L
L
V
L
I
A
V
A
R
60
  ICL1 TM2    
N
S
K
F
H
S
A
M
Y
L
70
                   
F
L
G
N
L
A
A
S
D
L
80
                   
L
A
G
V
A
F
V
A
N
T
90
    ECL1        
L
L
S
G
H
V
T
L
S
L
100
TM3              
T
P
V
Q
W
F
A
R
E
G
110
                   
S
A
F
I
T
L
S
A
S
V
120
                   
F
S
L
L
A
I
A
I
E
R
130
            ICL2
Q
V
A
L
A
K
V
K
L
Y
140
      TM4        
G
S
D
K
S
C
R
M
L
M
150
                   
L
I
G
A
S
W
L
I
S
L
160
                   
I
L
G
G
L
P
I
L
G
W
170
ECL2            
N
C
L
N
Q
L
E
A
C
S
180
            TM5  
T
V
L
P
L
Y
A
K
H
Y
190
                   
V
L
C
V
V
T
I
F
S
V
200
                   
I
L
L
A
I
V
A
L
Y
V
210
                   
R
I
Y
F
V
V
R
S
S
H
220
ICL3 TM6      
A
D
V
A
G
P
Q
T
L
A
230
                   
L
L
K
T
V
T
I
V
L
G
240
                   
V
F
I
I
C
W
L
P
A
F
250
                   
S
I
L
L
L
D
S
T
C
P
260
ECL3 TM7      
V
R
A
C
P
V
L
Y
K
A
270
                   
H
Y
F
F
A
F
A
T
L
N
280
                   
S
L
L
N
P
V
I
Y
T
W
290
  H8              
R
S
R
D
L
R
R
E
V
L
300
        C-term
R
P
L
Q
C
W
R
R
G
K
310
                   
G
V
T
G
R
R
G
G
N
P
320
                   
G
H
R
L
L
P
L
R
S
S
330
                   
S
S
L
E
R
G
M
H
M
P
340
                   
T
S
P
T
F
L
E
G
N
T
350
   
V
V

LINKS

DIAGRAMS

L N E V V I A C C L I I I F A S A V K R 1 G N L A A S D L L A G V A F V A N T L L 2 A L L S F V S A S L T I F A S G E R A F 3 M L M L I G A S W L I S L I L G G L P I 4 Y L A V I A L L I V S F I T V V C L V Y 5 T I V L G V F I I C W L P A F S I L L L 6 V P N L L S N L T A F A F F Y H A K Y 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

ICL1 S K F H ICL1ECL1 S G H V T L S L ECL1ICL2 V K L Y G S D ICL2ECL2 W N C L N Q L E A C S T V L P L Y ECL2ICL3 S H A D V ICL3ECL3 P V R A C ECL3N-term M G G L Y S E Y L N P E K V L E H Y N Y T K E T L D M Q E N-termC-term C W R R G K G V T G R R G G N P G H R L L P L R S S S S L E R G M H M P T S P T F L E G N T V V C-term T T S R K V A S A F I I I L C C A I V V E N L L V L I A V A R N S A M Y L F L G N L A A S D L L A G V A F V A N T L L T P V Q W F A R E G S A F I T L S A S V F S L L A I A I E R Q V A L A K K S C R M L M L I G A S W L I S L I L G G L P I L G A K H Y V L C V V T I F S V I L L A I V A L Y V R I Y F V V R S A G P Q T L A L L K T V T I V L G V F I I C W L P A F S I L L L D S T C P V L Y K A H Y F F A F A T L N S L L N P V I Y T W R S R D V L R L R R E P L Q
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

sphingosine 1-phosphate,

sphingosylphosphorylcholine

HOMOLOGY MODELS

No homology models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available