S1P5 receptor (s1pr5_mouse)

FAMILY

Class A (Rhodopsin) Lipid receptors Lysophospholipid (S1P) receptors S1P5 receptor

GENE

S1pr5 (Edg8, Lpb4)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Sphingosine 1-phosphate receptor 5, S1P receptor 5, S1P5, Endothelial differentiation G-protein-coupled receptor 8, Lysophospholipid receptor B4, Sphingosine 1-phosphate receptor Edg-8, S1P receptor Edg-8

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
E
P
G
L
L
R
P
A
P
10
                   
V
S
E
V
I
V
L
H
Y
N
20
                   
Y
T
G
K
L
R
G
A
R
Y
30
            TM1  
Q
P
G
A
G
L
R
A
D
A
40
                   
A
V
C
L
A
V
C
A
F
I
50
                   
V
L
E
N
L
A
V
L
L
V
60
        ICL1    
L
V
R
H
P
R
F
H
A
P
70
TM2              
M
F
L
L
L
G
S
L
T
L
80
                   
S
D
L
L
A
G
A
A
Y
A
90
            ECL1
T
N
I
L
L
S
G
P
L
T
100
      TM3        
L
R
L
S
P
A
L
W
F
A
110
                   
R
E
G
G
V
F
V
A
L
A
120
                   
A
S
V
L
S
L
L
A
I
A
130
                   
L
E
R
H
L
T
M
A
R
R
140
ICL2     TM4  
G
P
A
P
A
A
S
R
A
R
150
                   
T
L
A
M
A
V
A
A
W
G
160
                   
A
S
L
L
L
G
L
L
P
A
170
    ECL2        
L
G
W
N
C
L
G
R
L
E
180
                   
T
C
S
T
V
L
P
L
Y
A
190
TM5              
K
A
Y
V
L
F
C
V
L
A
200
                   
F
L
G
I
L
A
A
I
C
A
210
                   
L
Y
A
R
I
Y
C
Q
V
R
220
                   
A
N
A
R
R
L
R
A
G
P
230
        ICL3    
G
S
R
R
A
T
S
S
S
R
240
TM6              
S
R
H
T
P
R
S
L
A
L
250
                   
L
R
T
L
S
V
V
L
L
A
260
                   
F
V
A
C
W
G
P
L
F
L
270
                   
L
L
L
L
D
V
A
C
P
A
280
ECL3 TM7      
R
A
C
P
V
L
L
Q
A
D
290
                   
P
F
L
G
L
A
M
A
N
S
300
                   
L
L
N
P
I
I
Y
T
F
T
310
H8                
N
R
D
L
R
H
A
L
L
R
320
      C-term  
L
L
C
C
G
R
G
P
C
N
330
                   
Q
D
S
S
N
S
L
Q
R
S
340
                   
P
S
A
A
G
P
S
G
G
G
350
                   
L
R
R
C
L
P
P
T
L
D
360
                   
R
S
S
S
P
S
E
H
L
S
370
                   
P
Q
Q
D
G
V
D
T
S
C
380
                   
S
T
G
S
P
G
V
A
T
A
390
                   
N
R
S
L
V
P
T
A
T
D
400

LINKS

DIAGRAMS

L N E L V I F A C V A L C V A A D A R 1 G S L T L S D L L A G A A Y A T N I L L 2 A L L S L V S A A L A V F V G G E R A F 3 T L A M A V A A W G A S L L L G L L P A 4 Y L A C I A A L I G L F A L V C F L V Y 5 S V V L L A F V A C W G P L F L L L L L 6 I P N L L S N A M A L G L F P D A Q L 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

ICL1 P R F H ICL1ECL1 G P L T L R L ECL1ICL2 R G P A P A A ICL2ECL2 W N C L G R L E T C S T V L P L Y ECL2ICL3 A T S S S ICL3ECL3 P A R A C ECL3N-term M E P G L L R P A P V S E V I V L H Y N Y T G K L R G A R Y Q P G A G L N-termC-term C G R G P C N Q D S S N S L Q R S P S A A G P S G G G L R R C L P P T L D R S S S P S E H L S P Q Q D G V D T S C S T G S P G V A T A N R S L V P T A T D C-term R A D A A V C L A V C A F I V L E N L A V L L V L V R H A P M F L L L G S L T L S D L L A G A A Y A T N I L L S S P A L W F A R E G G V F V A L A A S V L S L L A I A L E R H L T M A R S R A R T L A M A V A A W G A S L L L G L L P A L G A K A Y V L F C V L A F L G I L A A I C A L Y A R I Y C Q V R A N A R R L R A G P G S R R R S R H T P R S L A L L R T L S V V L L A F V A C W G P L F L L L L L D V A C P V L L Q A D P F L G L A M A N S L L N P I I Y T F T N R D L L R L R H A L L C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

sphingosine 1-phosphate

HOMOLOGY MODELS

No homology models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available