TAS2R50 (t2r50_human)

FAMILY

Class T (Taste 2) Sensory receptors Taste 2 receptors TAS2R50

GENE

TAS2R50

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Taste receptor type 2 member 50, T2R50, Taste receptor type 2 member 51, T2R51

SOURCE

SWISSPROT

SEQUENCE

N-term TM1  
M
I
T
F
L
Y
I
F
F
S
10
                   
I
L
I
M
V
L
F
V
L
G
20
                   
N
F
A
N
G
F
I
A
L
V
30
                   
N
F
I
D
W
V
K
R
K
K
40
ICL1 TM2      
I
S
S
A
D
Q
I
L
T
A
50
                   
L
A
V
S
R
I
G
L
L
W
60
                   
A
L
L
L
N
W
Y
L
T
V
70
    ECL1 TM3  
L
N
P
A
F
Y
S
V
E
L
80
                   
R
I
T
S
Y
N
A
W
V
V
90
                   
T
N
H
F
S
M
W
L
A
A
100
                   
N
L
S
I
F
Y
L
L
K
I
110
  ICL2          
A
N
F
S
N
L
L
F
L
H
120
      TM4        
L
K
R
R
V
R
S
V
I
L
130
                   
V
I
L
L
G
T
L
I
F
L
140
                   
V
C
H
L
L
V
A
N
M
D
150
    ECL2        
E
S
M
W
A
E
E
Y
E
G
160
                   
N
M
T
G
K
M
K
L
R
N
170
          TM5    
T
V
H
L
S
Y
L
T
V
T
180
                   
T
L
W
S
F
I
P
F
T
L
190
                   
S
L
I
S
F
L
M
L
I
C
200
                   
S
L
C
K
H
L
K
K
M
Q
210
      ICL3 TM6
L
H
G
E
G
S
Q
D
L
S
220
                   
T
K
V
H
I
K
A
L
Q
T
230
                   
L
I
S
F
L
L
L
C
A
I
240
                   
F
F
L
F
L
I
V
S
V
W
250
        ECL3 TM7
S
P
R
R
L
R
N
D
P
V
260
                 
V
M
V
S
K
A
V
G
N
I
270
                   
Y
L
A
F
D
S
F
I
L
I
280
    H8            
W
R
T
K
K
L
K
H
T
F
290
                 
L
L
I
L
C
Q
I
R
C

LINKS

BitterDB

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 K I ICL1ECL1 P A F Y ECL1ICL2 N F S N L L F L H L K R ICL2ECL2 M W A E E Y E G N M T G K M K L R N T V H L S ECL2ICL3 E G S Q ICL3ECL3 L R N ECL3N-term M N-term I T F L Y I F F S I L I M V L F V L G N F A N G F I A L V N F I D W V K R K S S A D Q I L T A L A V S R I G L L W A L L L N W Y L T V L N S V E L R I T S Y N A W V V T N H F S M W L A A N L S I F Y L L K I A R V R S V I L V I L L G T L I F L V C H L L V A N M D E S Y L T V T T L W S F I P F T L S L I S F L M L I C S L C K H L K K M Q L H G D L S T K V H I K A L Q T L I S F L L L C A I F F L F L I V S V W S P R R D P V V M V S K A V G N I Y L A F D S F I L I W R T K K F L L I R C L K H T I L C Q
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N A F N G L V F L V M I L I S F F I Y 1 T A L A V S R I G L L W A L L L N W Y L 2 N A A L W M S F H N T V V W A N Y S T I 3 I L V I L L G T L I F L V C H L L V A N 4 F S I L S L T F P I F S W L T T V T L Y 5 L I S F L L L C A I F F L F L I V S V W 6 F S D F A L Y I N G V A K S V M V V P 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

t2r50_human active,

t2r50_human inactive

STRUCTURES

No structures available