G11 - ACKR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 H 148 3x56 G.hns1 A 36 G.hns1.01
Hydrophobic TM3 H 148 3x56 G.hns1 A 36 G.hns1.01
Van-der-waals TM3 H 148 3x56 G.hns1 A 36 G.hns1.01
Hydrophobic TM5 L 237 5x65 G.H5 L 353 G.H5.20
Ionic ICL2 R 154 34x55 G.h2s4 E 221 G.h2s4.02
Polar ICL2 R 154 34x55 G.h2s4 E 221 G.h2s4.02
Hydrophobic TM3 I 146 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 146 3x54 G.H5 L 358 G.H5.25
Hydrophobic ICL3 P 242 - G.H5 Q 350 G.H5.17
Van-der-waals ICL3 P 242 - G.H5 Q 350 G.H5.17
Polar TM3 K 142 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 K 142 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 K 142 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 146 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 146 3x54 G.H5 L 353 G.H5.20
Polar C-term M 362 - G.H2 R 214 G.H2.05
Hydrophobic C-term M 362 - G.H2 R 214 G.H2.05
Van-der-waals C-term M 362 - G.H2 R 214 G.H2.05
Hydrophobic TM3 I 146 3x54 G.H5 Y 356 G.H5.23
Polar TM3 E 145 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 E 145 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 E 145 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM5 L 240 5x68 G.S3 I 199 G.S3.01
Van-der-waals TM5 L 240 5x68 G.S3 I 199 G.S3.01
Polar TM6 A 248 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 248 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 248 6x33 G.H5 L 358 G.H5.25
Polar TM7 S 315 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM7 S 315 7x56 G.H5 N 357 G.H5.24
Polar TM2 R 79 2x37 G.h3s5 N 266 G.h3s5.02
Polar TM3 K 142 3x50 G.H5 N 357 G.H5.24
Hydrophobic TM3 K 142 3x50 G.H5 N 357 G.H5.24
Van-der-waals TM3 K 142 3x50 G.H5 N 357 G.H5.24
Hydrophobic TM6 A 248 6x33 G.H5 V 359 G.H5.26
Hydrophobic ICL2 A 149 34x50 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 A 149 34x50 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 P 151 34x52 G.h2s4 N 222 G.h2s4.03
Polar TM5 R 239 5x67 G.s2s3 E 197 G.s2s3.01
Hydrophobic TM5 R 239 5x67 G.s2s3 E 197 G.s2s3.01
Van-der-waals TM5 R 239 5x67 G.s2s3 E 197 G.s2s3.01
Ionic H8 R 318 8x49 G.H5 E 355 G.H5.22
Polar H8 R 318 8x49 G.H5 E 355 G.H5.22
Hydrophobic H8 R 318 8x49 G.H5 E 355 G.H5.22
Van-der-waals H8 R 318 8x49 G.H5 E 355 G.H5.22
Polar TM3 H 148 3x56 G.hns1 R 38 G.hns1.03
Hydrophobic TM3 H 148 3x56 G.hns1 R 38 G.hns1.03
Van-der-waals TM3 H 148 3x56 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 I 251 6x36 G.H5 L 358 G.H5.25
Polar TM5 R 239 5x67 G.s2s3 N 198 G.s2s3.02
Hydrophobic TM5 R 239 5x67 G.s2s3 N 198 G.s2s3.02
Van-der-waals TM5 R 239 5x67 G.s2s3 N 198 G.s2s3.02
Polar TM3 I 146 3x54 G.hns1 R 38 G.hns1.03
Polar TM3 E 145 3x53 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 A 149 34x50 G.H5 Y 356 G.H5.23
Hydrophobic TM5 L 240 5x68 G.H5 L 353 G.H5.20
Hydrophobic TM3 K 142 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM3 E 145 3x53 G.H5 E 355 G.H5.22
Van-der-waals TM3 E 145 3x53 G.H5 E 355 G.H5.22
Hydrophobic ICL2 R 156 34x57 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 156 34x57 G.H5 Y 356 G.H5.23
Polar ICL1 R 78 12x51 G.h3s5 Q 265 G.h3s5.01
Van-der-waals ICL1 R 78 12x51 G.h3s5 Q 265 G.h3s5.01
Van-der-waals TM6 R 247 6x32 G.H5 V 359 G.H5.26
Polar H8 S 316 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 S 316 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 S 316 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM5 I 233 5x61 G.H5 L 358 G.H5.25
Polar TM6 A 243 6x28 G.H5 Q 350 G.H5.17
Hydrophobic TM6 A 243 6x28 G.H5 Q 350 G.H5.17
Van-der-waals TM6 A 243 6x28 G.H5 Q 350 G.H5.17
Hydrophobic TM3 H 148 3x56 G.HN R 34 G.HN.52
Van-der-waals TM3 H 148 3x56 G.HN R 34 G.HN.52
Polar H8 R 320 8x51 G.H5 V 359 G.H5.26
Aromatic ICL2 Y 152 34x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 Y 152 34x53 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 Y 152 34x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 H 153 34x54 G.h2s4 N 222 G.h2s4.03
Van-der-waals ICL2 H 153 34x54 G.h2s4 N 222 G.h2s4.03
Hydrophobic TM5 Y 230 5x58 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 252 6x37 G.H5 L 358 G.H5.25
Hydrophobic ICL3 P 242 - G.H5 L 353 G.H5.20
Hydrophobic TM5 L 240 5x68 G.H5 L 349 G.H5.16
Hydrophobic TM3 E 145 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 E 145 3x53 G.H5 N 352 G.H5.19
Polar ICL2 A 149 34x50 G.S1 E 39 G.S1.01
Van-der-waals ICL2 A 149 34x50 G.S1 E 39 G.S1.01
Hydrophobic TM3 H 148 3x56 G.hns1 R 37 G.hns1.02
Ionic TM2 R 79 2x37 G.H5 E 355 G.H5.22