G13 - ACKR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 237 5x65 G.H5 L 371 G.H5.20
Polar TM2 R 79 2x37 G.H5 Q 377 G.H5.26
Hydrophobic TM2 R 79 2x37 G.H5 Q 377 G.H5.26
Van-der-waals TM2 R 79 2x37 G.H5 Q 377 G.H5.26
Hydrophobic TM3 E 145 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 E 145 3x53 G.H5 L 374 G.H5.23
Hydrophobic TM3 H 148 3x56 G.HN T 43 G.HN.52
Van-der-waals TM3 H 148 3x56 G.HN T 43 G.HN.52
Hydrophobic ICL2 P 151 34x52 G.H5 L 374 G.H5.23
Hydrophobic TM3 I 146 3x54 G.H5 M 375 G.H5.24
Hydrophobic TM6 A 248 6x33 G.H5 M 375 G.H5.24
Van-der-waals TM6 A 248 6x33 G.H5 M 375 G.H5.24
Hydrophobic ICL2 A 149 34x50 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 A 149 34x50 G.hns1 K 46 G.hns1.02
Polar ICL2 Y 152 34x53 G.H5 Q 377 G.H5.26
Hydrophobic ICL2 Y 152 34x53 G.H5 Q 377 G.H5.26
Van-der-waals ICL2 Y 152 34x53 G.H5 Q 377 G.H5.26
Hydrophobic ICL2 L 155 34x56 G.HN K 42 G.HN.51
Van-der-waals ICL2 L 155 34x56 G.HN K 42 G.HN.51
Polar H8 S 316 8x47 G.H5 L 376 G.H5.25
Hydrophobic H8 S 316 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 S 316 8x47 G.H5 L 376 G.H5.25
Ionic C-term E 357 - G.H4 K 324 G.H4.09
Hydrophobic C-term E 357 - G.H4 K 324 G.H4.09
Van-der-waals C-term E 357 - G.H4 K 324 G.H4.09
Hydrophobic TM5 L 240 5x68 G.H5 L 367 G.H5.16
Polar ICL2 H 153 34x54 G.h2s4 S 239 G.h2s4.03
Hydrophobic ICL2 H 153 34x54 G.h2s4 S 239 G.h2s4.03
Van-der-waals ICL2 H 153 34x54 G.h2s4 S 239 G.h2s4.03
Polar ICL2 Q 150 34x51 G.HN T 43 G.HN.52
Hydrophobic ICL2 Q 150 34x51 G.HN T 43 G.HN.52
Van-der-waals ICL2 Q 150 34x51 G.HN T 43 G.HN.52
Polar TM3 E 145 3x53 G.H5 Q 377 G.H5.26
Hydrophobic TM5 L 240 5x68 G.H5 L 371 G.H5.20
Van-der-waals TM5 L 240 5x68 G.H5 L 371 G.H5.20
Hydrophobic ICL2 A 149 34x50 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 A 149 34x50 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 P 151 34x52 G.S1 L 48 G.S1.01
Polar TM3 K 142 3x50 G.H5 Q 377 G.H5.26
Hydrophobic TM3 K 142 3x50 G.H5 Q 377 G.H5.26
Van-der-waals TM3 K 142 3x50 G.H5 Q 377 G.H5.26
Polar ICL2 P 151 34x52 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 P 151 34x52 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 P 151 34x52 G.hns1 K 46 G.hns1.02
Polar H8 H 317 8x48 G.H5 L 376 G.H5.25
Hydrophobic H8 H 317 8x48 G.H5 L 376 G.H5.25
Van-der-waals H8 H 317 8x48 G.H5 L 376 G.H5.25
Polar C-term E 357 - G.H4 R 320 G.H4.05
Van-der-waals C-term E 357 - G.H4 R 320 G.H4.05
Hydrophobic ICL2 L 155 34x56 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 L 155 34x56 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 Q 150 34x51 G.H5 L 374 G.H5.23
Hydrophobic ICL2 A 149 34x50 G.H5 L 374 G.H5.23
Polar H8 R 318 8x49 G.H5 L 376 G.H5.25
Van-der-waals H8 R 318 8x49 G.H5 L 376 G.H5.25
Van-der-waals C-term A 355 - G.H4 K 324 G.H4.09
Ionic C-term E 357 - G.H4 R 331 G.H4.16
Polar C-term E 357 - G.H4 R 331 G.H4.16
Hydrophobic ICL2 R 156 34x57 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 R 156 34x57 G.hns1 K 46 G.hns1.02
Hydrophobic TM5 L 237 5x65 G.H5 M 375 G.H5.24
Van-der-waals TM5 L 237 5x65 G.H5 M 375 G.H5.24
Polar H8 R 318 8x49 G.H5 Q 377 G.H5.26
Hydrophobic H8 R 318 8x49 G.H5 Q 377 G.H5.26
Van-der-waals H8 R 318 8x49 G.H5 Q 377 G.H5.26
Polar TM6 A 243 6x28 G.H5 H 368 G.H5.17
Hydrophobic TM6 A 243 6x28 G.H5 H 368 G.H5.17
Van-der-waals TM6 A 243 6x28 G.H5 H 368 G.H5.17
Van-der-waals TM3 H 148 3x56 G.hns1 K 46 G.hns1.02
Hydrophobic ICL3 P 242 - G.H5 L 371 G.H5.20
Hydrophobic C-term M 362 - G.H5 L 357 G.H5.06
Van-der-waals C-term M 362 - G.H5 L 357 G.H5.06
Polar TM3 V 147 3x55 G.hns1 R 47 G.hns1.03
Hydrophobic TM3 V 147 3x55 G.hns1 R 47 G.hns1.03
Van-der-waals TM3 V 147 3x55 G.hns1 R 47 G.hns1.03
Polar TM3 K 142 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 K 142 3x50 G.H5 L 374 G.H5.23
Hydrophobic C-term M 359 - G.H4 R 320 G.H4.05
Van-der-waals C-term M 359 - G.H4 R 320 G.H4.05
Hydrophobic H8 S 316 8x47 G.H5 Q 377 G.H5.26
Van-der-waals H8 S 316 8x47 G.H5 Q 377 G.H5.26
Hydrophobic ICL3 P 242 - G.H5 H 368 G.H5.17
Van-der-waals ICL3 P 242 - G.H5 H 368 G.H5.17
Polar H8 R 318 8x49 G.h3s5 N 283 G.h3s5.02
Van-der-waals H8 R 318 8x49 G.h3s5 N 283 G.h3s5.02
Polar ICL2 Q 150 34x51 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 Q 150 34x51 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 Q 150 34x51 G.hns1 K 46 G.hns1.02
Hydrophobic TM3 I 146 3x54 G.H5 L 374 G.H5.23
Polar TM3 H 148 3x56 G.hns1 R 47 G.hns1.03
Aromatic TM3 H 148 3x56 G.hns1 R 47 G.hns1.03
Hydrophobic TM3 H 148 3x56 G.hns1 R 47 G.hns1.03
Van-der-waals TM3 H 148 3x56 G.hns1 R 47 G.hns1.03
Hydrophobic TM3 I 146 3x54 G.H5 L 371 G.H5.20
Van-der-waals TM3 I 146 3x54 G.H5 L 371 G.H5.20
Aromatic ICL2 Y 152 34x53 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 Y 152 34x53 G.hns1 K 46 G.hns1.02
Hydrophobic TM2 V 81 2x39 G.H5 Q 377 G.H5.26