Gt2 - M4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM6 R 394 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 394 6x29 G.H5 K 345 G.H5.17
Polar ICL3 K 387 - G.S6 S 321 G.S6.03
Van-der-waals ICL3 K 387 - G.S6 S 321 G.S6.03
Aromatic TM6 K 397 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 397 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 397 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 I 402 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 405 6x40 G.H5 L 353 G.H5.25
Polar TM3 C 133 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 133 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 C 133 3x53 G.H5 N 347 G.H5.19
Polar TM3 R 130 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 218 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 C 133 3x53 G.H5 C 351 G.H5.23
Polar H8 N 457 8x47 G.H5 D 350 G.H5.22
Hydrophobic TM5 S 222 5x65 G.H5 L 348 G.H5.20
Ionic TM6 R 394 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 394 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 394 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 394 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 394 6x29 G.H5 I 344 G.H5.16
Hydrophobic TM6 R 394 6x29 G.H5 I 344 G.H5.16
Van-der-waals TM6 R 394 6x29 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 134 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 134 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 138 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM4 T 146 4x39 G.HN Q 24 G.HN.48
Van-der-waals TM4 T 146 4x39 G.HN Q 24 G.HN.48
Hydrophobic ICL2 L 138 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM3 V 134 3x54 G.H5 I 344 G.H5.16
Polar ICL2 A 142 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 A 142 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 A 142 34x55 G.hns1 K 32 G.hns1.03
Polar TM4 T 146 4x39 G.HN D 28 G.HN.52
Polar TM2 N 67 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 N 67 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 N 67 2x39 G.H5 C 351 G.H5.23
Polar H8 N 457 8x47 G.H5 K 349 G.H5.21
Ionic ICL2 R 143 34x56 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 143 34x56 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 143 34x56 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 143 34x56 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 L 138 34x51 G.s2s3 K 192 G.s2s3.01
Ionic ICL3 K 238 - G.H4 D 297 G.H4.04
Polar ICL3 K 238 - G.H4 D 297 G.H4.04
Hydrophobic ICL3 K 238 - G.H4 D 297 G.H4.04
Van-der-waals ICL3 K 238 - G.H4 D 297 G.H4.04
Hydrophobic ICL2 T 139 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 T 139 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 V 226 5x69 G.S6 Y 320 G.S6.02
Hydrophobic ICL2 A 142 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 A 142 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 R 130 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 R 225 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 225 5x68 G.H5 T 340 G.H5.12
Hydrophobic ICL2 A 142 34x55 G.S3 L 194 G.S3.01
Ionic C-term R 479 - G.h2s4 E 216 G.h2s4.02
Hydrophobic TM6 V 398 6x33 G.H5 L 348 G.H5.20
Ionic TM5 H 229 5x72 G.H5 D 337 G.H5.09
Aromatic TM6 R 394 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 394 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 394 6x29 G.H5 F 354 G.H5.26
Polar TM6 Q 390 6x25 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 Q 390 6x25 G.h4s6 K 314 G.h4s6.08
Polar TM6 V 398 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 398 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 398 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 137 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 R 394 6x29 G.H5 L 348 G.H5.20
Van-der-waals TM6 R 394 6x29 G.H5 L 348 G.H5.20
Hydrophobic ICL3 P 234 - G.H4 D 297 G.H4.04
Van-der-waals ICL3 P 234 - G.H4 D 297 G.H4.04
Hydrophobic TM7 C 456 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 C 456 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL3 R 386 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 R 386 - G.h4s6 K 314 G.h4s6.08
Polar ICL2 P 137 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 137 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM6 V 398 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 218 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM5 V 226 5x69 G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 138 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 138 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 138 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 138 34x51 G.H5 I 343 G.H5.15
Aromatic TM5 H 229 5x72 G.H5 F 334 G.H5.06
Hydrophobic TM5 H 229 5x72 G.H5 F 334 G.H5.06
Van-der-waals TM5 H 229 5x72 G.H5 F 334 G.H5.06
Polar TM2 N 67 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 137 34x50 G.H5 T 340 G.H5.12
Ionic ICL3 R 386 - G.H4 D 309 G.H4.17
Polar ICL2 T 139 34x52 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 T 139 34x52 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 T 139 34x52 G.s2s3 K 192 G.s2s3.01
Ionic TM5 R 225 5x68 G.H5 D 337 G.H5.09
Polar TM5 R 225 5x68 G.H5 D 337 G.H5.09
Polar TM6 T 401 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 401 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 137 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 137 34x50 G.H5 I 344 G.H5.16