Gt1 - α1A-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 74.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 15.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 132 34x51 G.H5 N 343 G.H5.19
Van-der-waals ICL2 L 132 34x51 G.H5 N 343 G.H5.19
Hydrophobic C-term F 399 - G.H2 R 201 G.H2.01
Van-der-waals C-term F 399 - G.H2 R 201 G.H2.01
Hydrophobic TM3 V 128 3x54 G.H5 L 349 G.H5.25
Van-der-waals TM3 V 128 3x54 G.H5 L 349 G.H5.25
Hydrophobic TM3 G 127 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 G 127 3x53 G.H5 C 347 G.H5.23
Ionic ICL3 H 256 - G.H5 D 337 G.H5.13
Polar C-term Y 386 - G.H3 H 252 G.H3.15
Aromatic C-term Y 386 - G.H3 H 252 G.H3.15
Hydrophobic C-term Y 386 - G.H3 H 252 G.H3.15
Van-der-waals C-term Y 386 - G.H3 H 252 G.H3.15
Hydrophobic C-term W 397 - G.H3 I 249 G.H3.12
Hydrophobic C-term W 397 - G.h2s4 F 211 G.h2s4.01
Van-der-waals C-term W 397 - G.h2s4 F 211 G.h2s4.01
Hydrophobic TM6 K 263 6x26 G.H5 I 340 G.H5.16
Van-der-waals TM6 K 263 6x26 G.H5 I 340 G.H5.16
Hydrophobic C-term F 385 - G.H3 S 248 G.H3.11
Hydrophobic TM3 G 127 3x53 G.H5 L 344 G.H5.20
Van-der-waals C-term W 397 - G.H3 S 248 G.H3.11
Hydrophobic TM6 R 266 6x29 G.H5 F 350 G.H5.26
Van-der-waals TM6 R 266 6x29 G.H5 F 350 G.H5.26
Hydrophobic ICL3 V 259 - G.H5 D 337 G.H5.13
Hydrophobic TM6 A 270 6x33 G.H5 L 349 G.H5.25
Polar H8 Q 331 8x48 G.H5 F 350 G.H5.26
Hydrophobic TM3 R 124 3x50 G.H5 L 349 G.H5.25
Van-der-waals TM3 R 124 3x50 G.H5 L 349 G.H5.25
Hydrophobic TM3 Y 130 3x56 G.hns1 R 28 G.hns1.03
Hydrophobic TM6 R 266 6x29 G.H5 K 341 G.H5.17
Van-der-waals TM6 R 266 6x29 G.H5 K 341 G.H5.17
Hydrophobic C-term C 395 - G.H2 I 208 G.H2.08
Van-der-waals C-term C 395 - G.H2 I 208 G.H2.08
Hydrophobic TM3 V 128 3x54 G.H5 L 344 G.H5.20
Polar ICL3 H 256 - G.H5 A 334 G.H5.10
Hydrophobic ICL3 H 256 - G.H5 A 334 G.H5.10
Van-der-waals ICL3 H 256 - G.H5 A 334 G.H5.10
Hydrophobic TM2 T 61 2x39 G.H5 C 347 G.H5.23
Polar TM2 T 61 2x39 G.H5 D 346 G.H5.22
Hydrophobic ICL3 H 256 - G.H5 D 333 G.H5.09
Van-der-waals ICL3 H 256 - G.H5 D 333 G.H5.09
Hydrophobic ICL1 H 56 12x49 G.h4s6 V 312 G.h4s6.10
Ionic ICL2 R 133 34x52 G.HN E 24 G.HN.52
Polar ICL2 R 133 34x52 G.HN E 24 G.HN.52
Hydrophobic ICL2 R 133 34x52 G.HN E 24 G.HN.52
Van-der-waals ICL2 R 133 34x52 G.HN E 24 G.HN.52
Hydrophobic TM6 L 274 6x37 G.H5 L 349 G.H5.25
Polar ICL3 H 256 - G.H5 F 330 G.H5.06
Aromatic ICL3 H 256 - G.H5 F 330 G.H5.06
Hydrophobic ICL3 H 256 - G.H5 F 330 G.H5.06
Van-der-waals ICL3 H 256 - G.H5 F 330 G.H5.06
Hydrophobic ICL2 R 133 34x52 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 R 133 34x52 G.hns1 R 28 G.hns1.03
Ionic H8 E 332 8x49 G.H5 K 345 G.H5.21
Polar H8 E 332 8x49 G.H5 K 345 G.H5.21
Hydrophobic H8 E 332 8x49 G.H5 K 345 G.H5.21
Van-der-waals H8 E 332 8x49 G.H5 K 345 G.H5.21
Hydrophobic C-term I 377 - G.H3 H 244 G.H3.07
Hydrophobic C-term V 379 - G.h4s6 M 308 G.h4s6.03
Van-der-waals C-term V 379 - G.h4s6 M 308 G.h4s6.03
Polar C-term Y 386 - G.H3 S 248 G.H3.11
Van-der-waals C-term Y 386 - G.H3 S 248 G.H3.11
Hydrophobic C-term W 397 - G.H2 K 205 G.H2.05
Polar ICL2 P 131 34x50 G.H5 N 343 G.H5.19
Hydrophobic ICL2 P 131 34x50 G.H5 N 343 G.H5.19
Van-der-waals ICL2 P 131 34x50 G.H5 N 343 G.H5.19
Hydrophobic C-term M 374 - G.hgh4 D 285 G.hgh4.04
Van-der-waals C-term M 374 - G.hgh4 D 285 G.hgh4.04
Hydrophobic ICL3 S 229 - G.H5 F 330 G.H5.06
Van-der-waals ICL3 S 229 - G.H5 F 330 G.H5.06
Ionic TM6 K 263 6x26 G.H5 D 337 G.H5.13
Polar TM6 K 263 6x26 G.H5 D 337 G.H5.13
Hydrophobic TM6 K 263 6x26 G.H5 D 337 G.H5.13
Van-der-waals TM6 K 263 6x26 G.H5 D 337 G.H5.13
Hydrophobic C-term I 388 - G.H3 R 253 G.H3.16
Van-der-waals C-term I 388 - G.H3 R 253 G.H3.16
Polar TM3 R 124 3x50 G.H5 C 347 G.H5.23
Polar TM7 S 329 7x56 G.H5 G 348 G.H5.24
Hydrophobic ICL2 Y 134 34x53 G.H5 C 347 G.H5.23
Van-der-waals ICL2 Y 134 34x53 G.H5 C 347 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.S1 V 30 G.S1.02
Van-der-waals ICL2 L 132 34x51 G.S1 V 30 G.S1.02
Polar ICL2 T 136 34x55 G.hns1 D 26 G.hns1.01
Hydrophobic ICL2 T 136 34x55 G.hns1 D 26 G.hns1.01
Hydrophobic ICL2 P 131 34x50 G.H5 I 340 G.H5.16
Polar ICL2 R 133 34x52 G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 R 133 34x52 G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 R 133 34x52 G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 L 132 34x51 G.H5 I 340 G.H5.16
Hydrophobic ICL2 L 132 34x51 G.H5 I 339 G.H5.15
Van-der-waals ICL2 L 132 34x51 G.H5 I 339 G.H5.15
Polar ICL2 T 136 34x55 G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 T 136 34x55 G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 T 136 34x55 G.hns1 A 27 G.hns1.02
Polar TM3 R 124 3x50 G.H5 G 348 G.H5.24
Van-der-waals TM3 R 124 3x50 G.H5 G 348 G.H5.24
Hydrophobic ICL2 I 137 34x56 G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 I 137 34x56 G.hns1 A 27 G.hns1.02
Polar TM2 S 59 2x37 G.H5 D 346 G.H5.22
Hydrophobic ICL2 L 132 34x51 G.S3 L 190 G.S3.01
Van-der-waals ICL2 L 132 34x51 G.S3 L 190 G.S3.01
Van-der-waals TM6 K 269 6x32 G.H5 F 350 G.H5.26