Gi2 - α1B-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 70.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 V 226 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 V 226 5x61 G.H5 L 354 G.H5.25
Polar ICL3 E 244 - G.S6 F 324 G.S6.05
Hydrophobic ICL3 E 244 - G.S6 F 324 G.S6.05
Van-der-waals ICL3 E 244 - G.S6 F 324 G.S6.05
Polar TM7 S 351 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM7 S 351 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 S 351 7x56 G.H5 G 353 G.H5.24
Polar ICL2 T 155 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 T 155 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 T 155 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL3 G 240 - G.H5 F 335 G.H5.06
Van-der-waals ICL3 G 240 - G.H5 F 335 G.H5.06
Polar ICL2 Q 152 34x52 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 Q 152 34x52 G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 L 151 34x51 G.H5 I 345 G.H5.16
Hydrophobic ICL3 G 240 - G.H5 A 339 G.H5.10
Hydrophobic TM5 L 237 5x72 G.H5 K 346 G.H5.17
Van-der-waals TM5 L 237 5x72 G.H5 K 346 G.H5.17
Polar TM3 R 143 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 143 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 143 3x50 G.H5 C 352 G.H5.23
Polar ICL2 T 155 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 155 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 155 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 S 150 34x50 G.H5 N 348 G.H5.19
Hydrophobic ICL2 S 150 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 S 150 34x50 G.H5 N 348 G.H5.19
Hydrophobic TM6 F 284 6x25 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 R 288 6x29 G.H5 K 346 G.H5.17
Van-der-waals TM6 R 288 6x29 G.H5 K 346 G.H5.17
Polar ICL2 L 151 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 151 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 151 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 T 233 5x68 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 151 34x51 G.H5 N 348 G.H5.19
Van-der-waals ICL2 L 151 34x51 G.H5 N 348 G.H5.19
Hydrophobic ICL2 L 151 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 151 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM4 T 158 4x38 G.HN E 28 G.HN.52
Polar TM3 R 143 3x50 G.H5 G 353 G.H5.24
Hydrophobic TM3 R 143 3x50 G.H5 G 353 G.H5.24
Van-der-waals TM3 R 143 3x50 G.H5 G 353 G.H5.24
Hydrophobic ICL2 L 151 34x51 G.H5 I 344 G.H5.15
Hydrophobic ICL2 P 154 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 P 154 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 R 288 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 R 288 6x29 G.H5 F 355 G.H5.26
Polar ICL2 Q 152 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 152 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 A 239 5x74 G.H5 F 335 G.H5.06
Van-der-waals TM5 A 239 5x74 G.H5 F 335 G.H5.06
Hydrophobic TM3 V 147 3x54 G.H5 L 354 G.H5.25
Van-der-waals TM3 V 147 3x54 G.H5 L 354 G.H5.25
Ionic ICL3 E 244 - G.S6 H 323 G.S6.04
Polar ICL3 E 244 - G.S6 H 323 G.S6.04
Hydrophobic ICL3 E 244 - G.S6 H 323 G.S6.04
Van-der-waals ICL3 E 244 - G.S6 H 323 G.S6.04
Polar TM5 N 236 5x71 G.H5 D 342 G.H5.13
Hydrophobic TM5 N 236 5x71 G.H5 D 342 G.H5.13
Van-der-waals TM5 N 236 5x71 G.H5 D 342 G.H5.13
Hydrophobic TM3 V 147 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 147 3x54 G.H5 L 349 G.H5.20
Polar ICL2 S 150 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 S 150 34x50 G.H5 I 345 G.H5.16
Ionic TM6 R 288 6x29 G.h4s6 E 319 G.h4s6.12
Polar TM6 R 288 6x29 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 R 288 6x29 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 R 288 6x29 G.h4s6 E 319 G.h4s6.12
Polar H8 K 353 8x48 G.h4s6 D 316 G.h4s6.09
Van-der-waals H8 K 353 8x48 G.h4s6 D 316 G.h4s6.09
Hydrophobic ICL2 L 151 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 151 34x51 G.S1 V 34 G.S1.02
Van-der-waals TM5 T 234 5x69 G.H5 F 355 G.H5.26
Hydrophobic ICL3 E 244 - G.H5 V 336 G.H5.07
Van-der-waals ICL3 E 244 - G.H5 V 336 G.H5.07
Hydrophobic ICL2 T 155 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 R 143 3x50 G.H5 L 354 G.H5.25
Polar C-term Y 388 - G.H3 H 245 G.H3.03
Hydrophobic C-term Y 388 - G.H3 H 245 G.H3.03
Van-der-waals C-term Y 388 - G.H3 H 245 G.H3.03
Van-der-waals ICL2 L 151 34x51 G.hns1 A 31 G.hns1.02
Polar TM3 G 146 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM3 G 146 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 G 146 3x53 G.H5 C 352 G.H5.23
Hydrophobic ICL3 K 243 - G.H5 F 335 G.H5.06
Van-der-waals ICL3 K 243 - G.H5 F 335 G.H5.06
Hydrophobic TM6 L 296 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 296 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM5 L 237 5x72 G.H5 D 342 G.H5.13
Van-der-waals TM5 L 237 5x72 G.H5 D 342 G.H5.13
Van-der-waals H8 R 357 8x52 G.h4s6 T 317 G.h4s6.10
Hydrophobic ICL2 S 150 34x50 G.H5 L 349 G.H5.20
Van-der-waals ICL2 S 150 34x50 G.H5 L 349 G.H5.20
Hydrophobic TM5 T 233 5x68 G.H5 K 346 G.H5.17
Ionic TM4 K 161 4x41 G.HN E 28 G.HN.52
Hydrophobic TM5 T 233 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 L 237 5x72 G.H5 V 343 G.H5.14
Van-der-waals TM5 L 237 5x72 G.H5 V 343 G.H5.14
Polar TM6 K 291 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 291 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 291 6x32 G.H5 F 355 G.H5.26
Hydrophobic ICL3 E 244 - G.H5 F 335 G.H5.06
Ionic ICL3 R 276 - G.H4 D 298 G.H4.04
Polar ICL3 R 276 - G.H4 D 298 G.H4.04
Hydrophobic ICL3 R 276 - G.H4 D 298 G.H4.04
Van-der-waals ICL3 R 276 - G.H4 D 298 G.H4.04