Gs - α1D-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 71.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 11.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 G 291 - G.S6 P 361 G.S6.03
Ionic ICL3 R 294 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 R 294 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 R 294 - G.hgh4 D 323 G.hgh4.13
Hydrophobic C-term L 561 - G.H2 K 233 G.H2.06
Van-der-waals C-term L 561 - G.H2 K 233 G.H2.06
Hydrophobic C-term V 539 - G.S2 V 214 G.S2.08
Hydrophobic TM5 V 280 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 280 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 K 293 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 V 292 - G.h4s6 T 350 G.h4s6.03
Polar C-term Y 564 - G.H2 R 232 G.H2.05
Hydrophobic C-term Y 564 - G.H2 R 232 G.H2.05
Van-der-waals C-term Y 564 - G.H2 R 232 G.H2.05
Polar ICL2 K 203 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 K 203 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 K 203 34x52 G.s2s3 D 215 G.s2s3.01
Polar TM6 K 345 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 345 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 345 6x32 G.H5 L 394 G.H5.26
Ionic C-term H 548 - G.h1ha E 74 G.h1ha.10
Polar C-term H 548 - G.h1ha E 74 G.h1ha.10
Hydrophobic C-term H 548 - G.h1ha E 74 G.h1ha.10
Van-der-waals C-term H 548 - G.h1ha E 74 G.h1ha.10
Aromatic ICL2 Y 204 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 204 34x53 G.H5 H 387 G.H5.19
Hydrophobic C-term V 539 - G.s2s3 D 215 G.s2s3.01
Van-der-waals C-term V 539 - G.s2s3 D 215 G.s2s3.01
Hydrophobic TM6 A 346 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 346 6x33 G.H5 L 393 G.H5.25
Ionic TM4 E 210 4x39 G.HN K 34 G.HN.51
Polar TM4 E 210 4x39 G.HN K 34 G.HN.51
Van-der-waals TM4 E 210 4x39 G.HN K 34 G.HN.51
Hydrophobic C-term A 558 - G.S2 F 208 G.S2.02
Hydrophobic C-term I 572 - G.H2 R 231 G.H2.04
Van-der-waals C-term I 572 - G.H2 R 231 G.H2.04
Hydrophobic TM5 L 288 5x72 G.H5 L 394 G.H5.26
Hydrophobic TM5 A 281 5x65 G.H5 L 388 G.H5.20
Polar TM5 T 284 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 T 284 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 202 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM2 T 131 2x39 G.H5 Y 391 G.H5.23
Aromatic TM3 R 194 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 194 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 194 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 205 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 L 202 34x51 G.H5 C 379 G.H5.11
Hydrophobic C-term L 561 - G.H2 Q 236 G.H2.09
Van-der-waals C-term L 561 - G.H2 Q 236 G.H2.09
Hydrophobic TM5 V 277 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 V 277 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 202 34x51 G.S3 F 219 G.S3.03
Hydrophobic ICL2 L 202 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 202 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM4 T 209 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 209 4x38 G.HN Q 35 G.HN.52
Hydrophobic ICL2 L 202 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 202 34x51 G.H5 R 380 G.H5.12
Polar TM6 T 349 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 349 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 349 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 S 201 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 288 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 L 288 5x72 G.H5 R 385 G.H5.17
Polar TM3 V 198 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 198 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 198 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 350 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 350 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 345 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 345 6x32 G.H5 E 392 G.H5.24
Polar C-term V 542 - G.S2 Q 213 G.S2.07
Van-der-waals C-term V 542 - G.S2 Q 213 G.S2.07
Hydrophobic ICL2 S 201 34x50 G.H5 I 383 G.H5.15
Hydrophobic C-term L 544 - G.S2 Q 213 G.S2.07
Van-der-waals C-term L 544 - G.S2 Q 213 G.S2.07
Hydrophobic C-term C 556 - G.S2 F 208 G.S2.02
Van-der-waals C-term C 556 - G.S2 F 208 G.S2.02
Hydrophobic TM3 V 198 3x54 G.H5 L 388 G.H5.20
Ionic TM4 E 210 4x39 G.hns1 R 38 G.hns1.02
Polar TM4 E 210 4x39 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 E 210 4x39 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 T 284 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 T 284 5x68 G.H5 R 385 G.H5.17
Hydrophobic C-term I 572 - G.H3 N 279 G.H3.15
Van-der-waals C-term I 572 - G.H3 N 279 G.H3.15
Hydrophobic TM3 V 198 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 202 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 202 34x51 G.H5 F 376 G.H5.08
Hydrophobic C-term L 544 - G.S3 N 218 G.S3.02
Van-der-waals C-term L 544 - G.S3 N 218 G.S3.02
Polar C-term L 561 - G.H2 R 232 G.H2.05
Van-der-waals C-term L 561 - G.H2 R 232 G.H2.05
Hydrophobic C-term I 572 - G.h2s4 F 238 G.h2s4.01
Polar TM4 E 210 4x39 G.HN Q 31 G.HN.48
Van-der-waals TM4 E 210 4x39 G.HN Q 31 G.HN.48
Hydrophobic ICL2 K 203 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 K 203 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL3 K 293 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 K 293 - G.H4 L 346 G.H4.16
Ionic C-term E 569 - G.H2 R 231 G.H2.04
Hydrophobic TM3 V 198 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 205 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 P 205 34x54 G.hns1 R 38 G.hns1.02
Polar ICL3 R 296 - G.hgh4 T 319 G.hgh4.09
Hydrophobic ICL3 R 296 - G.hgh4 T 319 G.hgh4.09
Van-der-waals ICL3 R 296 - G.hgh4 T 319 G.hgh4.09
Hydrophobic TM5 T 284 5x68 G.H5 L 388 G.H5.20
Polar ICL2 L 202 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 202 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 202 34x51 G.S1 H 41 G.S1.02
Ionic C-term E 569 - G.H2 R 228 G.H2.01
Polar ICL2 S 201 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 S 201 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM7 S 405 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 S 405 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL3 K 293 - G.H4 R 347 G.H4.17
Hydrophobic C-term L 567 - G.H2 I 235 G.H2.08
Hydrophobic ICL3 G 291 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 G 291 - G.H4 L 346 G.H4.16
Van-der-waals C-term A 541 - G.S2 Q 213 G.S2.07
Hydrophobic C-term S 543 - G.h1ha N 66 G.h1ha.02
Hydrophobic C-term I 572 - G.H2 R 232 G.H2.05
Van-der-waals C-term I 572 - G.H2 R 232 G.H2.05
Ionic ICL3 K 293 - G.H4 D 343 G.H4.13
Polar ICL3 K 293 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 K 293 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 K 293 - G.H4 D 343 G.H4.13
Hydrophobic TM5 L 288 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 L 288 5x72 G.h4s6 Y 358 G.h4s6.20
Polar TM3 G 197 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 G 197 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 G 197 3x53 G.H5 H 387 G.H5.19
Polar ICL2 S 201 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 S 201 34x50 G.H5 Q 384 G.H5.16
Polar C-term Y 564 - G.H2 Q 236 G.H2.09
Hydrophobic C-term Y 564 - G.H2 Q 236 G.H2.09
Van-der-waals C-term Y 564 - G.H2 Q 236 G.H2.09
Polar ICL1 Q 128 12x51 G.hns1 R 38 G.hns1.02
Hydrophobic C-term A 541 - G.H1 H 64 G.H1.12
Hydrophobic TM6 T 349 6x36 G.H5 L 393 G.H5.25
Ionic H8 K 410 8x51 G.H5 E 392 G.H5.24
Polar H8 K 410 8x51 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 342 6x29 G.H5 L 394 G.H5.26