Golf - ADGRB2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 59.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 17.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 R 965 2x46 G.H5 Q 377 G.H5.22
Van-der-waals TM2 R 965 2x46 G.H5 Q 377 G.H5.22
Hydrophobic TM6 L 1154 6x39 G.H5 L 380 G.H5.25
Polar TM3 Q 1020 3x53 G.H5 Y 378 G.H5.23
Hydrophobic TM3 Q 1020 3x53 G.H5 Y 378 G.H5.23
Van-der-waals TM3 Q 1020 3x53 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 M 1029 - G.H5 H 374 G.H5.19
Van-der-waals ICL2 M 1029 - G.H5 H 374 G.H5.19
Hydrophobic ICL3 L 1127 - G.hgh4 A 303 G.hgh4.06
Polar H8 R 1207 8x48 G.H5 E 379 G.H5.24
Hydrophobic H8 R 1207 8x48 G.H5 E 379 G.H5.24
Van-der-waals H8 R 1207 8x48 G.H5 E 379 G.H5.24
Hydrophobic C-term K 1473 - G.HN L 32 G.HN.47
Hydrophobic C-term L 1240 - G.hns1 K 40 G.hns1.02
Hydrophobic TM3 V 1025 3x58 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 1025 3x58 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 1025 3x58 G.H5 L 375 G.H5.20
Polar ICL3 R 1116 - G.h4s6 Y 345 G.h4s6.20
Hydrophobic ICL3 R 1116 - G.h4s6 Y 345 G.h4s6.20
Van-der-waals ICL3 R 1116 - G.h4s6 Y 345 G.h4s6.20
Hydrophobic C-term L 1469 - G.S2 I 194 G.S2.01
Polar TM3 V 1025 3x58 G.H5 Q 371 G.H5.16
Hydrophobic TM3 V 1025 3x58 G.H5 Q 371 G.H5.16
Van-der-waals TM3 V 1025 3x58 G.H5 Q 371 G.H5.16
Hydrophobic C-term S 1228 - G.H3 R 267 G.H3.16
Hydrophobic TM3 S 1021 3x54 G.H5 L 380 G.H5.25
Hydrophobic ICL3 K 1114 - G.H5 R 372 G.H5.17
Van-der-waals ICL3 K 1114 - G.H5 R 372 G.H5.17
Polar TM2 R 965 2x46 G.H5 Y 378 G.H5.23
Hydrophobic TM2 R 965 2x46 G.H5 Y 378 G.H5.23
Van-der-waals TM2 R 965 2x46 G.H5 Y 378 G.H5.23
Polar C-term S 1228 - G.h3s5 R 270 G.h3s5.01
Hydrophobic C-term S 1228 - G.h3s5 R 270 G.h3s5.01
Van-der-waals C-term S 1228 - G.h3s5 R 270 G.h3s5.01
Hydrophobic C-term L 1459 - G.H1 M 62 G.H1.08
Ionic C-term K 1473 - G.HN E 35 G.HN.50
Polar C-term K 1473 - G.HN E 35 G.HN.50
Van-der-waals C-term K 1473 - G.HN E 35 G.HN.50
Hydrophobic C-term V 1474 - G.hns1 Y 39 G.hns1.01
Van-der-waals C-term V 1474 - G.hns1 Y 39 G.hns1.01
Polar TM3 G 1027 3x60 G.H5 Q 371 G.H5.16
Hydrophobic TM3 G 1027 3x60 G.H5 Q 371 G.H5.16
Van-der-waals TM3 G 1027 3x60 G.H5 Q 371 G.H5.16
Hydrophobic TM6 S 1153 6x38 G.H5 E 379 G.H5.24
Van-der-waals TM6 S 1153 6x38 G.H5 E 379 G.H5.24
Hydrophobic C-term R 1273 - G.S2 F 195 G.S2.02
Ionic C-term D 1230 - G.h4s6 K 343 G.h4s6.12
Polar C-term D 1230 - G.h4s6 K 343 G.h4s6.12
Hydrophobic C-term D 1230 - G.h4s6 K 343 G.h4s6.12
Van-der-waals C-term D 1230 - G.h4s6 K 343 G.h4s6.12
Polar C-term E 1483 - G.H3 R 267 G.H3.16
Hydrophobic TM6 N 1149 6x34 G.H5 E 379 G.H5.24
Van-der-waals TM6 N 1149 6x34 G.H5 E 379 G.H5.24
Ionic C-term D 1230 - G.h3s5 R 270 G.h3s5.01
Polar C-term D 1230 - G.h3s5 R 270 G.h3s5.01
Hydrophobic C-term D 1230 - G.h3s5 R 270 G.h3s5.01
Van-der-waals C-term D 1230 - G.h3s5 R 270 G.h3s5.01
Van-der-waals C-term L 1237 - G.hns1 K 40 G.hns1.02
Hydrophobic C-term K 1462 - G.S2 F 195 G.S2.02
Van-der-waals C-term K 1462 - G.S2 F 195 G.S2.02
Polar C-term Y 1466 - G.H2 Q 223 G.H2.09
Hydrophobic C-term Y 1466 - G.H2 Q 223 G.H2.09
Van-der-waals C-term Y 1466 - G.H2 Q 223 G.H2.09
Hydrophobic C-term L 1469 - G.S3 F 209 G.S3.06
Van-der-waals C-term L 1469 - G.S3 F 209 G.S3.06
Hydrophobic TM3 A 1024 3x57 G.H5 L 380 G.H5.25
Polar C-term L 1240 - G.HN R 36 G.HN.51
Hydrophobic C-term L 1240 - G.HN R 36 G.HN.51
Polar ICL3 S 1112 - G.H4 R 329 G.H4.12
Van-der-waals ICL3 S 1112 - G.H4 R 329 G.H4.12
Polar ICL3 G 1118 - G.h4s6 T 337 G.h4s6.03
Van-der-waals ICL3 G 1118 - G.h4s6 T 337 G.h4s6.03
Hydrophobic TM5 L 1102 5x61 G.H5 L 375 G.H5.20
Hydrophobic C-term M 1456 - G.H5 I 359 G.H5.04
Van-der-waals C-term M 1456 - G.H5 I 359 G.H5.04
Aromatic C-term R 1461 - G.S2 F 195 G.S2.02
Hydrophobic C-term R 1461 - G.S2 F 195 G.S2.02
Van-der-waals C-term R 1461 - G.S2 F 195 G.S2.02
Hydrophobic C-term R 1461 - G.S2 E 196 G.S2.03
Van-der-waals C-term R 1461 - G.S2 E 196 G.S2.03
Hydrophobic C-term E 1460 - G.S2 T 197 G.S2.04
Van-der-waals C-term E 1460 - G.S2 T 197 G.S2.04
Hydrophobic ICL3 A 1117 - G.h4s6 T 339 G.h4s6.08
Ionic C-term E 1460 - G.S2 R 198 G.S2.05
Polar C-term E 1460 - G.S2 R 198 G.S2.05
Hydrophobic C-term E 1460 - G.S2 R 198 G.S2.05
Van-der-waals C-term E 1460 - G.S2 R 198 G.S2.05
Hydrophobic ICL3 Q 1115 - G.H4 L 333 G.H4.16
Van-der-waals ICL3 Q 1115 - G.H4 L 333 G.H4.16
Hydrophobic ICL3 Q 1115 - G.h4s6 T 337 G.h4s6.03
Hydrophobic H8 R 1206 8x47 G.H5 E 379 G.H5.24
Van-der-waals H8 R 1206 8x47 G.H5 E 379 G.H5.24
Hydrophobic C-term M 1454 - G.H5 F 363 G.H5.08
Van-der-waals C-term M 1454 - G.H5 F 363 G.H5.08
Hydrophobic C-term L 1484 - G.H3 W 268 G.H3.17
Van-der-waals C-term L 1484 - G.H3 W 268 G.H3.17
Hydrophobic C-term P 1229 - G.H3 R 267 G.H3.16
Van-der-waals C-term P 1229 - G.H3 R 267 G.H3.16
Polar ICL2 R 1032 - G.HN L 37 G.HN.52
Hydrophobic ICL2 R 1032 - G.HN L 37 G.HN.52
Van-der-waals ICL2 R 1032 - G.HN L 37 G.HN.52
Hydrophobic C-term L 1459 - G.S2 R 198 G.S2.05
Van-der-waals C-term L 1459 - G.S2 R 198 G.S2.05
Polar TM6 N 1149 6x34 G.H5 L 381 G.H5.26
Hydrophobic TM6 N 1149 6x34 G.H5 L 381 G.H5.26
Van-der-waals TM6 N 1149 6x34 G.H5 L 381 G.H5.26
Hydrophobic ICL3 K 1113 - G.S6 H 349 G.S6.04
Hydrophobic C-term M 1454 - G.H5 R 360 G.H5.05
Hydrophobic C-term M 1454 - G.S2 V 201 G.S2.08
Hydrophobic C-term P 1229 - G.H3 W 268 G.H3.17
Van-der-waals C-term P 1229 - G.H3 W 268 G.H3.17
Hydrophobic C-term F 1243 - G.h2s4 N 226 G.h2s4.02
Van-der-waals C-term F 1243 - G.h2s4 N 226 G.h2s4.02
Polar ICL2 R 1030 - G.s2s3 D 202 G.s2s3.01
Van-der-waals ICL2 R 1030 - G.s2s3 D 202 G.s2s3.01
Hydrophobic C-term L 1459 - G.H1 R 63 G.H1.09
Polar C-term I 1239 - G.h2s4 N 226 G.h2s4.02
Hydrophobic C-term I 1239 - G.h2s4 N 226 G.h2s4.02
Van-der-waals C-term I 1239 - G.h2s4 N 226 G.h2s4.02
Hydrophobic C-term K 1463 - G.S2 I 194 G.S2.01
Van-der-waals C-term K 1463 - G.S2 I 194 G.S2.01
Hydrophobic TM2 S 963 2x44 G.H5 Q 377 G.H5.22
Van-der-waals TM2 S 963 2x44 G.H5 Q 377 G.H5.22
Hydrophobic C-term L 1271 - G.h1ha V 67 G.h1ha.01
Polar ICL3 C 1134 - G.hgh4 E 309 G.hgh4.12
Hydrophobic ICL3 C 1134 - G.hgh4 E 309 G.hgh4.12
Van-der-waals ICL3 C 1134 - G.hgh4 E 309 G.hgh4.12
Hydrophobic C-term R 1273 - G.hfs2 V 189 G.hfs2.03
Hydrophobic C-term L 1464 - G.S2 E 196 G.S2.03
Van-der-waals C-term L 1464 - G.S2 E 196 G.S2.03
Ionic C-term E 1244 - G.HN R 36 G.HN.51
Polar C-term E 1244 - G.HN R 36 G.HN.51
Van-der-waals C-term E 1244 - G.HN R 36 G.HN.51
Hydrophobic C-term R 1461 - G.S2 T 197 G.S2.04
Hydrophobic C-term F 1471 - G.H2 Q 223 G.H2.09
Van-der-waals C-term F 1471 - G.H2 Q 223 G.H2.09
Ionic C-term E 1487 - G.H3 R 267 G.H3.16
Polar C-term E 1487 - G.H3 R 267 G.H3.16
Hydrophobic C-term E 1487 - G.H3 R 267 G.H3.16
Van-der-waals C-term E 1487 - G.H3 R 267 G.H3.16
Hydrophobic ICL3 A 1117 - G.h4s6 S 336 G.h4s6.02
Van-der-waals ICL3 A 1117 - G.h4s6 S 336 G.h4s6.02
Hydrophobic C-term H 1481 - G.H2 I 222 G.H2.08
Van-der-waals C-term H 1481 - G.H2 I 222 G.H2.08
Hydrophobic C-term K 1463 - G.S2 F 195 G.S2.02
Van-der-waals C-term K 1463 - G.S2 F 195 G.S2.02
Polar H8 E 1208 8x49 G.H5 Q 377 G.H5.22
Hydrophobic H8 E 1208 8x49 G.H5 Q 377 G.H5.22
Van-der-waals H8 E 1208 8x49 G.H5 Q 377 G.H5.22
Hydrophobic TM3 A 1024 3x57 G.H5 H 374 G.H5.19
Hydrophobic ICL3 G 1118 - G.h4s6 G 340 G.h4s6.09
Polar TM3 A 1024 3x57 G.H5 Q 371 G.H5.16
Hydrophobic TM3 A 1024 3x57 G.H5 Q 371 G.H5.16
Van-der-waals TM3 A 1024 3x57 G.H5 Q 371 G.H5.16
Hydrophobic ICL3 L 1127 - G.hgh4 N 304 G.hgh4.07
Van-der-waals ICL3 L 1127 - G.hgh4 N 304 G.hgh4.07
Hydrophobic C-term M 1456 - G.S2 Q 200 G.S2.07
Van-der-waals C-term M 1456 - G.S2 Q 200 G.S2.07
Hydrophobic ICL3 L 1127 - G.hgh4 Y 302 G.hgh4.05
Ionic TM2 R 965 2x46 G.H5 E 379 G.H5.24
Polar TM2 R 965 2x46 G.H5 E 379 G.H5.24
Hydrophobic TM2 R 965 2x46 G.H5 E 379 G.H5.24
Van-der-waals TM2 R 965 2x46 G.H5 E 379 G.H5.24
Hydrophobic ICL3 A 1117 - G.h4s6 G 340 G.h4s6.09
Van-der-waals ICL3 A 1117 - G.h4s6 G 340 G.h4s6.09
Hydrophobic ICL3 A 1117 - G.h4s6 T 337 G.h4s6.03
Van-der-waals ICL3 A 1117 - G.h4s6 T 337 G.h4s6.03
Hydrophobic ICL3 K 1113 - G.S6 P 348 G.S6.03
Van-der-waals ICL3 K 1113 - G.S6 P 348 G.S6.03
Polar C-term S 1452 - G.H5 R 360 G.H5.05
Van-der-waals C-term S 1452 - G.H5 R 360 G.H5.05
Ionic TM5 R 1105 5x64 G.H5 D 368 G.H5.13
Polar TM5 R 1105 5x64 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 1105 5x64 G.H5 D 368 G.H5.13
Hydrophobic C-term D 1230 - G.h3s5 T 271 G.h3s5.02
Hydrophobic C-term L 1240 - G.hns1 Y 39 G.hns1.01
Polar C-term H 1481 - G.H2 Q 223 G.H2.09
Hydrophobic C-term H 1481 - G.H2 Q 223 G.H2.09
Hydrophobic ICL3 L 1129 - G.hgh4 Y 305 G.hgh4.08
Van-der-waals ICL3 L 1129 - G.hgh4 Y 305 G.hgh4.08
Hydrophobic C-term L 1464 - G.S3 F 209 G.S3.06
Van-der-waals C-term L 1464 - G.S3 F 209 G.S3.06
Hydrophobic TM5 V 1098 5x57 G.H5 L 380 G.H5.25
Ionic C-term D 1227 - G.H3 R 267 G.H3.16
Polar C-term D 1227 - G.H3 R 267 G.H3.16
Hydrophobic C-term D 1227 - G.H3 R 267 G.H3.16
Van-der-waals C-term D 1227 - G.H3 R 267 G.H3.16
Hydrophobic ICL3 L 1127 - G.hgh4 E 301 G.hgh4.04
Van-der-waals ICL3 L 1127 - G.hgh4 E 301 G.hgh4.04
Ionic ICL3 K 1114 - G.H5 D 368 G.H5.13
Polar ICL3 K 1114 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 K 1114 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 K 1114 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 K 1113 - G.S6 C 346 G.S6.01
Hydrophobic C-term L 1271 - G.H1 R 63 G.H1.09
Hydrophobic C-term L 1469 - G.H2 C 224 G.H2.10
Hydrophobic C-term V 1474 - G.h2s4 N 226 G.h2s4.02
Polar TM6 S 1153 6x38 G.H5 Y 378 G.H5.23
Hydrophobic TM6 S 1153 6x38 G.H5 Y 378 G.H5.23
Van-der-waals TM6 S 1153 6x38 G.H5 Y 378 G.H5.23
Hydrophobic C-term L 1459 - G.h1ha V 67 G.h1ha.01
Van-der-waals C-term L 1459 - G.h1ha V 67 G.h1ha.01
Hydrophobic C-term L 1459 - G.S2 F 199 G.S2.06
Van-der-waals C-term L 1459 - G.S2 F 199 G.S2.06
Hydrophobic C-term Q 1236 - G.H5 M 373 G.H5.18
Van-der-waals C-term Q 1236 - G.H5 M 373 G.H5.18
Hydrophobic TM3 A 1024 3x57 G.H5 Y 378 G.H5.23
Polar C-term L 1464 - G.S2 I 194 G.S2.01
Van-der-waals C-term L 1464 - G.S2 I 194 G.S2.01
Polar C-term K 1463 - G.hfs2 S 192 G.hfs2.06
Hydrophobic C-term K 1463 - G.hfs2 S 192 G.hfs2.06
Van-der-waals C-term K 1463 - G.hfs2 S 192 G.hfs2.06
Hydrophobic ICL3 L 1129 - G.H4 D 330 G.H4.13
Van-der-waals ICL3 L 1129 - G.H4 D 330 G.H4.13
Hydrophobic ICL3 K 1114 - G.S6 Y 347 G.S6.02
Van-der-waals ICL3 K 1114 - G.S6 Y 347 G.S6.02
Hydrophobic C-term R 1480 - G.H3 W 268 G.H3.17
Van-der-waals C-term R 1480 - G.H3 W 268 G.H3.17
Hydrophobic C-term M 1456 - G.S2 V 201 G.S2.08
Hydrophobic ICL3 L 1129 - G.H4 R 334 G.H4.17
Hydrophobic C-term Y 1466 - G.S2 I 194 G.S2.01
Van-der-waals C-term Y 1466 - G.S2 I 194 G.S2.01
Hydrophobic C-term R 1461 - G.H1 V 59 G.H1.05
Van-der-waals C-term R 1461 - G.H1 V 59 G.H1.05
Hydrophobic C-term L 1484 - G.H2 I 222 G.H2.08
Van-der-waals C-term L 1484 - G.H2 I 222 G.H2.08
Hydrophobic TM5 D 1106 5x65 G.H5 L 381 G.H5.26
Polar C-term Q 1236 - G.hns1 K 40 G.hns1.02
Polar TM5 R 1105 5x64 G.H5 Q 371 G.H5.16
Hydrophobic TM5 R 1105 5x64 G.H5 Q 371 G.H5.16
Van-der-waals TM5 R 1105 5x64 G.H5 Q 371 G.H5.16
Hydrophobic C-term L 1240 - G.h2s4 D 227 G.h2s4.03
Van-der-waals C-term L 1240 - G.h2s4 D 227 G.h2s4.03
Hydrophobic TM6 S 1153 6x38 G.H5 L 380 G.H5.25
Van-der-waals TM6 S 1153 6x38 G.H5 L 380 G.H5.25
Hydrophobic C-term M 1456 - G.H1 H 66 G.H1.12
Van-der-waals C-term M 1456 - G.H1 H 66 G.H1.12
Hydrophobic C-term Y 1466 - G.H2 K 220 G.H2.06
Van-der-waals C-term Y 1466 - G.H2 K 220 G.H2.06
Van-der-waals C-term S 1458 - G.S2 R 198 G.S2.05
Hydrophobic ICL3 R 1116 - G.h4s6 T 337 G.h4s6.03
Van-der-waals ICL3 R 1116 - G.h4s6 T 337 G.h4s6.03
Polar TM5 S 1109 5x68 G.H5 R 372 G.H5.17
Van-der-waals TM5 S 1109 5x68 G.H5 R 372 G.H5.17
Hydrophobic TM3 I 1026 3x59 G.H5 Q 371 G.H5.16
Polar TM6 A 1150 6x35 G.H5 E 379 G.H5.24
Polar C-term G 1457 - G.S2 Q 200 G.S2.07
Hydrophobic C-term G 1457 - G.S2 Q 200 G.S2.07
Van-der-waals C-term G 1457 - G.S2 Q 200 G.S2.07
Hydrophobic C-term M 1456 - G.S2 F 199 G.S2.06
Van-der-waals C-term M 1456 - G.S2 F 199 G.S2.06
Polar H8 E 1208 8x49 G.H5 E 379 G.H5.24
Hydrophobic C-term L 1459 - G.S2 T 197 G.S2.04
Van-der-waals C-term L 1459 - G.S2 T 197 G.S2.04
Ionic C-term R 1461 - G.S3 D 210 G.S3.07
Polar C-term R 1461 - G.S3 D 210 G.S3.07
Van-der-waals C-term R 1461 - G.S3 D 210 G.S3.07
Hydrophobic TM5 L 1102 5x61 G.H5 L 380 G.H5.25
Van-der-waals TM5 L 1102 5x61 G.H5 L 380 G.H5.25
Polar C-term K 1462 - G.S2 E 196 G.S2.03
Van-der-waals C-term K 1462 - G.S2 E 196 G.S2.03
Hydrophobic TM3 A 1024 3x57 G.H5 L 375 G.H5.20
Hydrophobic TM6 A 1150 6x35 G.H5 L 380 G.H5.25
Hydrophobic ICL2 M 1029 - G.H5 Y 378 G.H5.23
Van-der-waals ICL2 M 1029 - G.H5 Y 378 G.H5.23
Polar C-term P 1450 - G.H5 R 360 G.H5.05
Hydrophobic C-term P 1450 - G.H5 R 360 G.H5.05
Van-der-waals C-term P 1450 - G.H5 R 360 G.H5.05