Gq - ADGRB2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 60.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.6
PAE mean: 17.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term F 1492 - G.H3 I 258 G.H3.12
Van-der-waals C-term F 1492 - G.H3 I 258 G.H3.12
Hydrophobic C-term Y 1485 - G.H2 H 218 G.H2.09
Hydrophobic TM5 G 1107 5x66 G.H5 A 342 G.H5.09
Van-der-waals ICL3 K 1113 - G.S6 Y 325 G.S6.02
Polar ICL3 R 1116 - G.h4s6 S 320 G.h4s6.11
Van-der-waals ICL3 R 1116 - G.h4s6 S 320 G.h4s6.11
Hydrophobic TM5 I 1108 5x67 G.H5 A 343 G.H5.10
Van-der-waals TM5 I 1108 5x67 G.H5 A 343 G.H5.10
Ionic H8 R 1207 8x48 G.h4s6 D 321 G.h4s6.12
Polar H8 R 1207 8x48 G.h4s6 D 321 G.h4s6.12
Van-der-waals H8 R 1207 8x48 G.h4s6 D 321 G.h4s6.12
Hydrophobic C-term L 1488 - G.H2 I 217 G.H2.08
Van-der-waals C-term L 1488 - G.H2 I 217 G.H2.08
Hydrophobic C-term F 1492 - G.H3 Y 261 G.H3.15
Hydrophobic ICL3 K 1114 - G.h4s6 I 323 G.h4s6.20
Ionic C-term E 1244 - G.HN K 33 G.HN.51
Polar C-term E 1244 - G.HN K 33 G.HN.51
Hydrophobic C-term E 1244 - G.HN K 33 G.HN.51
Van-der-waals C-term E 1244 - G.HN K 33 G.HN.51
Hydrophobic C-term H 1481 - G.H2 I 217 G.H2.08
Van-der-waals C-term H 1481 - G.H2 I 217 G.H2.08
Van-der-waals ICL3 Q 1115 - G.h4s6 I 323 G.h4s6.20
Hydrophobic ICL3 A 1117 - G.h4s6 N 317 G.h4s6.08
Van-der-waals ICL3 A 1117 - G.h4s6 N 317 G.h4s6.08
Polar TM6 S 1153 6x38 G.H5 Y 356 G.H5.23
Polar C-term F 1492 - G.H2 R 213 G.H2.04
Aromatic C-term F 1492 - G.H2 R 213 G.H2.04
Hydrophobic C-term F 1492 - G.H2 R 213 G.H2.04
Van-der-waals C-term F 1492 - G.H2 R 213 G.H2.04
Hydrophobic TM5 L 1102 5x61 G.H5 L 353 G.H5.20
Van-der-waals TM5 L 1102 5x61 G.H5 L 353 G.H5.20
Hydrophobic TM5 I 1108 5x67 G.H5 F 339 G.H5.06
Van-der-waals TM5 I 1108 5x67 G.H5 F 339 G.H5.06
Hydrophobic TM5 R 1105 5x64 G.H5 L 349 G.H5.16
Van-der-waals TM5 R 1105 5x64 G.H5 L 349 G.H5.16
Hydrophobic TM3 A 1024 3x57 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 1024 3x57 G.H5 Y 356 G.H5.23
Hydrophobic TM5 R 1105 5x64 G.H5 K 345 G.H5.12
Polar C-term R 1506 - G.hgh4 P 293 G.hgh4.03
Hydrophobic C-term R 1506 - G.hgh4 P 293 G.hgh4.03
Polar TM2 R 965 2x46 G.H5 Y 356 G.H5.23
Hydrophobic TM2 R 965 2x46 G.H5 Y 356 G.H5.23
Van-der-waals TM2 R 965 2x46 G.H5 Y 356 G.H5.23
Hydrophobic C-term L 1484 - G.H3 W 263 G.H3.17
Polar C-term H 1493 - G.H2 R 214 G.H2.05
Aromatic C-term H 1493 - G.H2 R 214 G.H2.05
Hydrophobic C-term H 1493 - G.H2 R 214 G.H2.05
Van-der-waals C-term H 1493 - G.H2 R 214 G.H2.05
Hydrophobic TM6 A 1150 6x35 G.H5 V 359 G.H5.26
Hydrophobic C-term F 1495 - G.H3 E 250 G.H3.04
Hydrophobic ICL3 K 1113 - G.H5 F 339 G.H5.06
Hydrophobic C-term K 1491 - G.H3 Y 261 G.H3.15
Van-der-waals C-term K 1491 - G.H3 Y 261 G.H3.15
Polar C-term Y 1485 - G.H2 R 214 G.H2.05
Hydrophobic C-term Y 1485 - G.H2 R 214 G.H2.05
Van-der-waals C-term Y 1485 - G.H2 R 214 G.H2.05
Hydrophobic ICL3 S 1146 - G.H5 V 359 G.H5.26
Hydrophobic C-term F 1492 - G.h2s4 F 220 G.h2s4.01
Polar TM5 G 1107 5x66 G.H5 D 346 G.H5.13
Hydrophobic TM5 G 1107 5x66 G.H5 D 346 G.H5.13
Van-der-waals TM5 G 1107 5x66 G.H5 D 346 G.H5.13
Hydrophobic C-term Q 1252 - G.HN L 29 G.HN.47
Van-der-waals C-term Q 1252 - G.HN L 29 G.HN.47
Ionic ICL3 R 1116 - G.h4s6 D 321 G.h4s6.12
Hydrophobic ICL3 A 1117 - G.h4s6 S 320 G.h4s6.11
Hydrophobic C-term F 1492 - G.H3 T 257 G.H3.11
Hydrophobic ICL2 M 1029 - G.H5 Y 356 G.H5.23
Van-der-waals ICL2 M 1029 - G.H5 Y 356 G.H5.23
Hydrophobic C-term D 1230 - G.H3 P 262 G.H3.16
Van-der-waals C-term D 1230 - G.H3 P 262 G.H3.16
Polar ICL3 Q 1115 - G.S6 I 324 G.S6.01
Van-der-waals ICL3 Q 1115 - G.S6 I 324 G.S6.01
Hydrophobic C-term F 1495 - G.H3 T 257 G.H3.11
Van-der-waals C-term F 1495 - G.H3 T 257 G.H3.11
Hydrophobic ICL3 Q 1115 - G.H4 V 314 G.H4.16
Van-der-waals ICL3 Q 1115 - G.H4 V 314 G.H4.16
Hydrophobic ICL3 A 1117 - G.h4s6 D 319 G.h4s6.10
Ionic C-term D 1248 - G.HN K 33 G.HN.51
Polar C-term D 1248 - G.HN K 33 G.HN.51
Hydrophobic C-term D 1248 - G.HN K 33 G.HN.51
Van-der-waals C-term D 1248 - G.HN K 33 G.HN.51
Hydrophobic C-term L 1484 - G.H2 I 217 G.H2.08
Hydrophobic TM3 V 1025 3x58 G.H5 L 353 G.H5.20
Polar C-term D 1230 - G.h3s5 Q 265 G.h3s5.01
Hydrophobic C-term D 1230 - G.h3s5 Q 265 G.h3s5.01
Van-der-waals C-term D 1230 - G.h3s5 Q 265 G.h3s5.01
Polar H8 E 1208 8x49 G.H5 N 357 G.H5.24
Van-der-waals H8 E 1208 8x49 G.H5 N 357 G.H5.24
Hydrophobic C-term L 1563 - G.H1 R 60 G.H1.09
Van-der-waals C-term L 1563 - G.H1 R 60 G.H1.09
Hydrophobic TM6 S 1153 6x38 G.H5 L 358 G.H5.25
Van-der-waals TM6 S 1153 6x38 G.H5 L 358 G.H5.25
Hydrophobic C-term L 1565 - G.H1 H 63 G.H1.12
Hydrophobic C-term K 1491 - G.H3 T 257 G.H3.11
Hydrophobic H8 R 1206 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 R 1206 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM6 N 1149 6x34 G.H5 L 358 G.H5.25
Van-der-waals TM6 N 1149 6x34 G.H5 L 358 G.H5.25
Hydrophobic ICL3 K 1114 - G.S6 Y 325 G.S6.02
Polar H8 R 1207 8x48 G.H5 N 357 G.H5.24
Van-der-waals H8 R 1207 8x48 G.H5 N 357 G.H5.24
Hydrophobic ICL3 R 1116 - G.h4s6 I 323 G.h4s6.20
Ionic C-term R 1499 - G.s4h3 E 245 G.s4h3.14
Polar C-term R 1499 - G.s4h3 E 245 G.s4h3.14
Van-der-waals C-term R 1499 - G.s4h3 E 245 G.s4h3.14
Aromatic C-term F 1492 - G.H2 W 216 G.H2.07
Hydrophobic C-term F 1492 - G.H2 W 216 G.H2.07
Hydrophobic TM6 L 1154 6x39 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 1154 6x39 G.H5 L 358 G.H5.25
Polar C-term N 1489 - G.H2 R 214 G.H2.05
Hydrophobic C-term N 1489 - G.H2 R 214 G.H2.05
Van-der-waals C-term N 1489 - G.H2 R 214 G.H2.05
Polar ICL2 T 1031 - G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 T 1031 - G.hns1 R 37 G.hns1.02
Ionic ICL3 K 1114 - G.H5 D 346 G.H5.13
Polar ICL3 K 1114 - G.H5 D 346 G.H5.13
Hydrophobic ICL3 K 1114 - G.H5 D 346 G.H5.13
Van-der-waals ICL3 K 1114 - G.H5 D 346 G.H5.13
Polar TM6 A 1150 6x35 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 1150 6x35 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 1150 6x35 G.H5 L 358 G.H5.25
Polar TM6 S 1153 6x38 G.H5 N 357 G.H5.24
Hydrophobic TM6 S 1153 6x38 G.H5 N 357 G.H5.24
Van-der-waals TM6 S 1153 6x38 G.H5 N 357 G.H5.24
Hydrophobic C-term F 1492 - G.H3 L 254 G.H3.08
Hydrophobic C-term Y 1498 - G.H3 R 256 G.H3.10
Van-der-waals C-term Y 1498 - G.H3 R 256 G.H3.10
Hydrophobic TM3 V 1025 3x58 G.H5 L 349 G.H5.16
Hydrophobic TM5 I 1108 5x67 G.H5 A 342 G.H5.09
Van-der-waals TM5 I 1108 5x67 G.H5 A 342 G.H5.09
Aromatic C-term H 1481 - G.H3 W 263 G.H3.17
Hydrophobic C-term H 1481 - G.H3 W 263 G.H3.17
Van-der-waals C-term H 1481 - G.H3 W 263 G.H3.17
Hydrophobic C-term V 1247 - G.h2s4 E 221 G.h2s4.02
Van-der-waals C-term V 1247 - G.h2s4 E 221 G.h2s4.02
Van-der-waals C-term F 1495 - G.H2 R 213 G.H2.04
Hydrophobic C-term H 1493 - G.H2 S 211 G.H2.02
Hydrophobic C-term D 1248 - G.HN L 29 G.HN.47
Hydrophobic ICL3 A 1117 - G.h4s6 P 318 G.h4s6.09
Hydrophobic ICL3 Q 1115 - G.H4 L 310 G.H4.12
Van-der-waals ICL3 Q 1115 - G.H4 L 310 G.H4.12
Hydrophobic ICL3 R 1116 - G.H4 V 314 G.H4.16
Hydrophobic C-term L 1488 - G.h2s4 F 220 G.h2s4.01
Van-der-waals C-term L 1488 - G.h2s4 F 220 G.h2s4.01
Hydrophobic TM3 V 1025 3x58 G.H5 L 358 G.H5.25
Hydrophobic C-term F 1243 - G.h2s4 N 222 G.h2s4.03
Hydrophobic TM3 S 1021 3x54 G.H5 L 358 G.H5.25
Polar C-term H 1493 - G.H2 R 210 G.H2.01
Hydrophobic C-term H 1493 - G.H2 R 210 G.H2.01
Van-der-waals C-term H 1493 - G.H2 R 210 G.H2.01
Hydrophobic C-term F 1495 - G.H3 L 254 G.H3.08
Van-der-waals C-term F 1495 - G.H3 L 254 G.H3.08
Polar TM3 Q 1020 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 Q 1020 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 Q 1020 3x53 G.H5 Y 356 G.H5.23
Polar TM3 A 1024 3x57 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 1024 3x57 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 1024 3x57 G.H5 N 352 G.H5.19
Hydrophobic C-term Y 1485 - G.H2 I 217 G.H2.08
Van-der-waals C-term Y 1485 - G.H2 I 217 G.H2.08
Polar C-term W 1510 - G.HG D 290 G.HG.17
Hydrophobic C-term W 1510 - G.HG D 290 G.HG.17
Van-der-waals C-term W 1510 - G.HG D 290 G.HG.17
Polar TM6 N 1149 6x34 G.H5 V 359 G.H5.26
Hydrophobic TM6 N 1149 6x34 G.H5 V 359 G.H5.26
Van-der-waals TM6 N 1149 6x34 G.H5 V 359 G.H5.26
Ionic C-term E 1244 - G.hns1 R 37 G.hns1.02
Polar C-term E 1244 - G.hns1 R 37 G.hns1.02
Hydrophobic C-term E 1244 - G.hns1 R 37 G.hns1.02
Van-der-waals C-term E 1244 - G.hns1 R 37 G.hns1.02
Polar ICL3 Q 1115 - G.S6 S 326 G.S6.03
Hydrophobic ICL3 Q 1115 - G.S6 S 326 G.S6.03
Van-der-waals ICL3 Q 1115 - G.S6 S 326 G.S6.03
Hydrophobic C-term F 1256 - G.HN I 25 G.HN.43
Van-der-waals C-term F 1256 - G.HN I 25 G.HN.43
Polar ICL2 R 1030 - G.HN R 34 G.HN.52
Van-der-waals ICL2 R 1030 - G.HN R 34 G.HN.52
Hydrophobic C-term F 1243 - G.h2s4 E 221 G.h2s4.02
Van-der-waals C-term F 1243 - G.h2s4 E 221 G.h2s4.02
Hydrophobic TM5 I 1108 5x67 G.S6 Y 325 G.S6.02
Van-der-waals TM5 I 1108 5x67 G.S6 Y 325 G.S6.02
Hydrophobic C-term L 1565 - G.h1ha G 64 G.h1ha.01
Van-der-waals C-term L 1565 - G.h1ha G 64 G.h1ha.01
Polar ICL3 K 1113 - G.S6 S 326 G.S6.03
Van-der-waals ICL3 K 1113 - G.S6 S 326 G.S6.03
Hydrophobic C-term L 1488 - G.H3 Y 261 G.H3.15
Van-der-waals C-term L 1488 - G.H3 Y 261 G.H3.15
Hydrophobic C-term F 1495 - G.H3 A 253 G.H3.07
Van-der-waals C-term F 1495 - G.H3 A 253 G.H3.07
Polar C-term L 1563 - G.h1ha S 65 G.h1ha.02
Hydrophobic C-term L 1563 - G.h1ha S 65 G.h1ha.02
Van-der-waals C-term L 1563 - G.h1ha S 65 G.h1ha.02