Gs - ADGRB2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 58.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.5
PAE mean: 18.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term M 1475 - G.h2s4 F 238 G.h2s4.01
Van-der-waals C-term M 1475 - G.h2s4 F 238 G.h2s4.01
Hydrophobic C-term L 1464 - G.S2 E 209 G.S2.03
Hydrophobic TM3 I 1026 3x59 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 1026 3x59 G.H5 Q 384 G.H5.16
Polar TM5 S 1109 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 S 1109 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 S 1109 5x68 G.H5 R 385 G.H5.17
Ionic C-term R 1478 - G.h2s4 D 240 G.h2s4.03
Polar C-term R 1461 - G.H1 S 54 G.H1.02
Hydrophobic C-term L 1459 - G.H1 R 61 G.H1.09
Van-der-waals C-term L 1459 - G.H1 R 61 G.H1.09
Hydrophobic C-term H 1493 - G.HN A 22 G.HN.39
Hydrophobic C-term H 1476 - G.H3 W 281 G.H3.17
Hydrophobic C-term D 1246 - G.hns1 A 39 G.hns1.03
Van-der-waals C-term D 1246 - G.hns1 A 39 G.hns1.03
Polar C-term S 1225 - G.h3s5 R 283 G.h3s5.01
Hydrophobic C-term D 1230 - G.H3 W 281 G.H3.17
Van-der-waals C-term D 1230 - G.H3 W 281 G.H3.17
Hydrophobic C-term Y 1485 - G.HN L 30 G.HN.47
Van-der-waals C-term Y 1485 - G.HN L 30 G.HN.47
Polar C-term Q 1236 - G.H3 W 281 G.H3.17
Ionic C-term D 1242 - G.hns1 R 38 G.hns1.02
Polar C-term D 1242 - G.hns1 R 38 G.hns1.02
Hydrophobic C-term D 1242 - G.hns1 R 38 G.hns1.02
Van-der-waals C-term D 1242 - G.hns1 R 38 G.hns1.02
Polar ICL3 S 1112 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 S 1112 - G.H4 R 342 G.H4.12
Polar C-term Y 1466 - G.H2 Q 236 G.H2.09
Hydrophobic C-term Y 1466 - G.H2 Q 236 G.H2.09
Van-der-waals C-term Y 1466 - G.H2 Q 236 G.H2.09
Ionic C-term R 1447 - H.hbhc D 139 H.hbhc.03
Polar C-term R 1447 - H.hbhc D 139 H.hbhc.03
Hydrophobic C-term R 1447 - H.hbhc D 139 H.hbhc.03
Van-der-waals C-term R 1447 - H.hbhc D 139 H.hbhc.03
Polar TM6 N 1149 6x34 G.H5 L 394 G.H5.26
Hydrophobic TM6 N 1149 6x34 G.H5 L 394 G.H5.26
Van-der-waals TM6 N 1149 6x34 G.H5 L 394 G.H5.26
Hydrophobic TM3 A 1024 3x57 G.H5 L 393 G.H5.25
Hydrophobic ICL3 K 1113 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 K 1113 - G.H4 L 346 G.H4.16
Hydrophobic ICL3 K 1114 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 K 1114 - G.H5 R 385 G.H5.17
Hydrophobic TM5 L 1102 5x61 G.H5 L 388 G.H5.20
Hydrophobic C-term A 1250 - G.S3 V 217 G.S3.01
Van-der-waals C-term A 1250 - G.S3 V 217 G.S3.01
Polar C-term R 1461 - G.hfs2 T 204 G.hfs2.05
Van-der-waals C-term R 1461 - G.hfs2 T 204 G.hfs2.05
Aromatic C-term R 1461 - G.S2 F 208 G.S2.02
Hydrophobic C-term R 1461 - G.S2 F 208 G.S2.02
Van-der-waals C-term R 1461 - G.S2 F 208 G.S2.02
Hydrophobic C-term L 1459 - G.S2 T 210 G.S2.04
Van-der-waals C-term L 1459 - G.S2 T 210 G.S2.04
Hydrophobic C-term F 1471 - G.H2 R 232 G.H2.05
Van-der-waals C-term F 1471 - G.H2 R 232 G.H2.05
Hydrophobic C-term Y 1466 - G.S2 I 207 G.S2.01
Hydrophobic C-term H 1493 - G.HN I 26 G.HN.43
Van-der-waals C-term H 1493 - G.HN I 26 G.HN.43
Hydrophobic TM3 S 1021 3x54 G.H5 L 393 G.H5.25
Polar C-term S 1265 - G.h1ha E 75 G.h1ha.11
Hydrophobic C-term S 1265 - G.h1ha E 75 G.h1ha.11
Van-der-waals C-term S 1265 - G.h1ha E 75 G.h1ha.11
Polar C-term L 1237 - G.H5 Q 390 G.H5.22
Hydrophobic C-term L 1237 - G.H5 Q 390 G.H5.22
Van-der-waals C-term L 1237 - G.H5 Q 390 G.H5.22
Hydrophobic ICL3 Q 1115 - G.h4s6 T 350 G.h4s6.03
Polar ICL3 K 1114 - G.S6 Y 360 G.S6.02
Hydrophobic ICL3 K 1114 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 K 1114 - G.S6 Y 360 G.S6.02
Hydrophobic TM3 V 1025 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 1025 3x58 G.H5 L 388 G.H5.20
Polar H8 R 1207 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 R 1207 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 R 1207 8x48 G.H5 E 392 G.H5.24
Hydrophobic C-term S 1228 - G.H3 R 280 G.H3.16
Polar C-term Q 1236 - G.h3s5 T 284 G.h3s5.02
Hydrophobic C-term Q 1236 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term Q 1236 - G.h3s5 T 284 G.h3s5.02
Polar H8 R 1207 8x48 G.H5 L 394 G.H5.26
Hydrophobic TM2 S 963 2x44 G.H5 Q 390 G.H5.22
Polar TM3 V 1025 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 1025 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 1025 3x58 G.H5 Q 384 G.H5.16
Hydrophobic C-term K 1462 - G.S2 F 208 G.S2.02
Hydrophobic C-term F 1471 - G.H2 I 235 G.H2.08
Van-der-waals C-term F 1471 - G.H2 I 235 G.H2.08
Hydrophobic H8 R 1206 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 R 1206 8x47 G.H5 E 392 G.H5.24
Polar ICL3 S 1112 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 S 1112 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 S 1112 - G.hgh4 D 323 G.hgh4.13
Hydrophobic C-term A 1250 - G.s2s3 K 216 G.s2s3.02
Van-der-waals C-term A 1250 - G.s2s3 K 216 G.s2s3.02
Ionic ICL3 K 1114 - G.H5 D 381 G.H5.13
Polar ICL3 K 1114 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 K 1114 - G.H5 D 381 G.H5.13
Polar C-term K 1462 - G.S2 E 209 G.S2.03
Hydrophobic C-term F 1243 - G.H5 I 383 G.H5.15
Van-der-waals C-term F 1243 - G.H5 I 383 G.H5.15
Hydrophobic TM6 N 1149 6x34 G.H5 E 392 G.H5.24
Van-der-waals TM6 N 1149 6x34 G.H5 E 392 G.H5.24
Polar ICL3 Q 1115 - G.h4s6 S 349 G.h4s6.02
Hydrophobic C-term S 1458 - G.h1ha V 65 G.h1ha.01
Ionic C-term R 1461 - G.S3 D 223 G.S3.07
Polar C-term R 1461 - G.S3 D 223 G.S3.07
Van-der-waals C-term R 1461 - G.S3 D 223 G.S3.07
Polar C-term T 1477 - G.h2s4 N 239 G.h2s4.02
Hydrophobic C-term T 1477 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term T 1477 - G.h2s4 N 239 G.h2s4.02
Polar C-term R 1478 - G.h2s4 N 239 G.h2s4.02
Hydrophobic TM5 V 1098 5x57 G.H5 L 393 G.H5.25
Polar TM3 A 1024 3x57 G.H5 Q 384 G.H5.16
Hydrophobic TM3 A 1024 3x57 G.H5 Q 384 G.H5.16
Van-der-waals TM3 A 1024 3x57 G.H5 Q 384 G.H5.16
Hydrophobic C-term L 1459 - G.h1ha V 65 G.h1ha.01
Hydrophobic C-term N 1489 - G.HN I 26 G.HN.43
Van-der-waals C-term N 1489 - G.HN I 26 G.HN.43
Hydrophobic C-term D 1246 - G.S1 H 41 G.S1.02
Hydrophobic C-term P 1264 - G.h1ha G 73 G.h1ha.09
Van-der-waals C-term P 1264 - G.h1ha G 73 G.h1ha.09
Polar TM2 R 965 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 965 2x46 G.H5 Y 391 G.H5.23
Polar TM6 S 1153 6x38 G.H5 E 392 G.H5.24
Hydrophobic TM6 S 1153 6x38 G.H5 E 392 G.H5.24
Van-der-waals TM6 S 1153 6x38 G.H5 E 392 G.H5.24
Hydrophobic C-term M 1475 - G.H2 I 235 G.H2.08
Van-der-waals C-term M 1475 - G.H2 I 235 G.H2.08
Hydrophobic C-term V 1247 - G.H5 I 383 G.H5.15
Van-der-waals C-term V 1247 - G.H5 I 383 G.H5.15
Hydrophobic ICL3 A 1117 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 A 1117 - G.h4s6 T 350 G.h4s6.03
Ionic TM5 R 1105 5x64 G.H5 D 381 G.H5.13
Polar TM5 R 1105 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 R 1105 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 1105 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM6 S 1153 6x38 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 1153 6x38 G.H5 L 393 G.H5.25
Hydrophobic C-term M 1475 - G.H3 W 281 G.H3.17
Van-der-waals C-term M 1475 - G.H3 W 281 G.H3.17
Ionic C-term E 1244 - G.H5 H 387 G.H5.19
Polar C-term E 1244 - G.H5 H 387 G.H5.19
Hydrophobic C-term E 1244 - G.H5 H 387 G.H5.19
Van-der-waals C-term E 1244 - G.H5 H 387 G.H5.19
Polar TM6 A 1150 6x35 G.H5 E 392 G.H5.24
Hydrophobic ICL3 K 1114 - G.h4s6 Y 358 G.h4s6.20
Polar C-term K 1257 - G.s2s3 K 216 G.s2s3.02
Hydrophobic C-term K 1463 - G.S2 F 208 G.S2.02
Hydrophobic C-term M 1306 - G.HN M 1 G.HN.01
Hydrophobic TM3 A 1024 3x57 G.H5 L 388 G.H5.20
Hydrophobic ICL3 K 1114 - G.S6 P 361 G.S6.03
Ionic C-term K 1455 - G.h1ha E 74 G.h1ha.10
Polar C-term K 1455 - G.h1ha E 74 G.h1ha.10
Hydrophobic C-term K 1455 - G.h1ha E 74 G.h1ha.10
Van-der-waals C-term K 1455 - G.h1ha E 74 G.h1ha.10
Hydrophobic ICL3 K 1114 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 K 1114 - G.S6 C 359 G.S6.01
Hydrophobic C-term C 1251 - G.S3 V 217 G.S3.01
Polar TM5 R 1105 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 R 1105 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 1105 5x64 G.H5 Q 384 G.H5.16
Hydrophobic C-term Y 1485 - G.HN I 26 G.HN.43
Polar H8 E 1208 8x49 G.H5 Q 390 G.H5.22
Hydrophobic H8 E 1208 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 E 1208 8x49 G.H5 Q 390 G.H5.22
Polar TM3 Q 1020 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 Q 1020 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Q 1020 3x53 G.H5 Y 391 G.H5.23
Ionic ICL3 R 1116 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 R 1116 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 R 1116 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 R 1116 - G.hgh4 D 323 G.hgh4.13
Hydrophobic C-term L 1464 - G.S3 F 222 G.S3.06
Ionic C-term D 1227 - G.H3 R 280 G.H3.16
Polar C-term D 1227 - G.H3 R 280 G.H3.16
Hydrophobic C-term D 1227 - G.H3 R 280 G.H3.16
Van-der-waals C-term D 1227 - G.H3 R 280 G.H3.16
Hydrophobic ICL3 K 1114 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 K 1114 - G.H4 L 346 G.H4.16
Polar C-term S 1228 - G.h3s5 R 283 G.h3s5.01
Hydrophobic C-term S 1228 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term S 1228 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term K 1463 - G.S2 I 207 G.S2.01
Hydrophobic C-term F 1243 - G.S1 T 40 G.S1.01
Polar C-term L 1464 - G.S2 I 207 G.S2.01
Hydrophobic C-term L 1464 - G.S2 I 207 G.S2.01
Van-der-waals C-term L 1464 - G.S2 I 207 G.S2.01
Hydrophobic C-term L 1240 - G.H5 M 386 G.H5.18
Van-der-waals C-term L 1240 - G.H5 M 386 G.H5.18
Van-der-waals C-term R 1461 - G.S2 E 209 G.S2.03
Polar ICL2 R 1032 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 R 1032 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 R 1032 - G.HN Q 35 G.HN.52
Hydrophobic TM3 V 1025 3x58 G.H5 L 393 G.H5.25
Van-der-waals C-term E 1460 - G.S2 E 209 G.S2.03
Polar C-term K 1463 - G.hfs2 S 205 G.hfs2.06
Hydrophobic C-term K 1463 - G.hfs2 S 205 G.hfs2.06
Van-der-waals C-term K 1463 - G.hfs2 S 205 G.hfs2.06
Aromatic C-term F 1243 - G.S1 H 41 G.S1.02
Hydrophobic C-term F 1243 - G.S1 H 41 G.S1.02
Van-der-waals C-term F 1243 - G.S1 H 41 G.S1.02
Hydrophobic TM3 A 1024 3x57 G.H5 Y 391 G.H5.23
Hydrophobic C-term D 1246 - G.hns1 R 38 G.hns1.02
Van-der-waals C-term D 1246 - G.hns1 R 38 G.hns1.02
Hydrophobic C-term I 1239 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term I 1239 - G.h2s4 D 240 G.h2s4.03
Polar TM6 S 1153 6x38 G.H5 Y 391 G.H5.23
Hydrophobic TM6 S 1153 6x38 G.H5 Y 391 G.H5.23
Van-der-waals TM6 S 1153 6x38 G.H5 Y 391 G.H5.23
Hydrophobic C-term F 1243 - G.hns1 R 38 G.hns1.02
Polar C-term E 1244 - G.H5 Y 391 G.H5.23
Hydrophobic C-term E 1244 - G.H5 Y 391 G.H5.23
Van-der-waals C-term E 1244 - G.H5 Y 391 G.H5.23
Hydrophobic C-term V 1254 - G.s2s3 D 215 G.s2s3.01
Van-der-waals C-term V 1254 - G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 M 1029 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 M 1029 - G.H5 Y 391 G.H5.23
Polar C-term R 1447 - H.hbhc P 138 H.hbhc.02
Hydrophobic C-term R 1447 - H.hbhc P 138 H.hbhc.02
Van-der-waals C-term R 1447 - H.hbhc P 138 H.hbhc.02
Hydrophobic C-term V 1247 - G.S1 H 41 G.S1.02
Van-der-waals C-term V 1247 - G.S1 H 41 G.S1.02
Ionic C-term E 1472 - G.H3 R 280 G.H3.16
Polar C-term E 1472 - G.H3 R 280 G.H3.16
Van-der-waals C-term E 1472 - G.H3 R 280 G.H3.16
Ionic TM2 R 965 2x46 G.H5 E 392 G.H5.24
Polar TM2 R 965 2x46 G.H5 E 392 G.H5.24
Hydrophobic TM2 R 965 2x46 G.H5 E 392 G.H5.24
Van-der-waals TM2 R 965 2x46 G.H5 E 392 G.H5.24
Hydrophobic C-term K 1463 - G.hfs2 G 206 G.hfs2.07
Polar TM3 G 1027 3x60 G.H5 Q 384 G.H5.16
Hydrophobic TM3 G 1027 3x60 G.H5 Q 384 G.H5.16
Van-der-waals TM3 G 1027 3x60 G.H5 Q 384 G.H5.16
Polar C-term S 1231 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term S 1231 - G.h4s6 R 356 G.h4s6.12
Hydrophobic ICL2 M 1029 - G.H5 H 387 G.H5.19
Polar H8 E 1208 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM6 A 1150 6x35 G.H5 L 393 G.H5.25
Polar C-term T 1253 - G.s2s3 K 216 G.s2s3.02
Hydrophobic C-term T 1253 - G.s2s3 K 216 G.s2s3.02
Van-der-waals C-term T 1253 - G.s2s3 K 216 G.s2s3.02
Hydrophobic C-term F 1243 - G.h2s4 T 242 G.h2s4.05
Van-der-waals C-term F 1243 - G.h2s4 T 242 G.h2s4.05
Polar C-term V 1254 - G.s2s3 K 216 G.s2s3.02
Hydrophobic C-term V 1254 - G.s2s3 K 216 G.s2s3.02
Van-der-waals C-term V 1254 - G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 L 1102 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 1102 5x61 G.H5 L 393 G.H5.25
Polar TM2 R 965 2x46 G.H5 Q 390 G.H5.22
Hydrophobic ICL3 K 1113 - G.S6 P 361 G.S6.03
Van-der-waals ICL3 K 1113 - G.S6 P 361 G.S6.03
Polar C-term S 1241 - G.H5 Q 390 G.H5.22
Hydrophobic C-term S 1241 - G.H5 Q 390 G.H5.22
Van-der-waals C-term S 1241 - G.H5 Q 390 G.H5.22