Gi3 - ADGRD1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 16.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 741 5x64 G.H5 K 345 G.H5.17
Van-der-waals TM5 I 741 5x64 G.H5 K 345 G.H5.17
Hydrophobic TM5 I 741 5x64 G.H5 Y 354 G.H5.26
Hydrophobic TM3 M 660 3x57 G.H5 C 351 G.H5.23
Van-der-waals TM3 M 660 3x57 G.H5 C 351 G.H5.23
Polar ICL2 S 670 - G.HN R 24 G.HN.48
Van-der-waals ICL2 S 670 - G.HN R 24 G.HN.48
Hydrophobic TM3 V 661 3x58 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 738 5x61 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 738 5x61 G.H5 L 348 G.H5.20
Polar TM6 K 760 6x40 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 760 6x40 G.H5 Y 354 G.H5.26
Hydrophobic TM5 V 737 5x60 G.H5 I 344 G.H5.16
Polar TM4 H 672 4x43 G.HN R 24 G.HN.48
Aromatic TM4 H 672 4x43 G.HN R 24 G.HN.48
Hydrophobic TM4 H 672 4x43 G.HN R 24 G.HN.48
Van-der-waals TM4 H 672 4x43 G.HN R 24 G.HN.48
Hydrophobic C-term V 874 - G.H3 K 248 G.H3.07
Van-der-waals C-term V 874 - G.H3 K 248 G.H3.07
Hydrophobic TM3 L 657 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL2 F 665 - G.H5 I 343 G.H5.15
Polar TM5 N 745 5x68 G.H5 K 345 G.H5.17
Van-der-waals TM5 N 745 5x68 G.H5 K 345 G.H5.17
Hydrophobic TM6 V 764 6x44 G.H5 L 353 G.H5.25
Polar TM2 R 601 2x46 G.H5 C 351 G.H5.23
Hydrophobic TM2 R 601 2x46 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 601 2x46 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 738 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 741 5x64 G.H5 L 348 G.H5.20
Polar TM2 R 601 2x46 G.H5 E 350 G.H5.22
Hydrophobic TM2 R 601 2x46 G.H5 E 350 G.H5.22
Van-der-waals TM2 R 601 2x46 G.H5 E 350 G.H5.22
Polar TM3 M 660 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 M 660 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 M 660 3x57 G.H5 N 347 G.H5.19
Ionic TM3 K 663 3x60 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 V 664 - G.H5 T 340 G.H5.12
Hydrophobic TM6 L 757 6x37 G.H5 Y 354 G.H5.26
Van-der-waals TM6 L 757 6x37 G.H5 Y 354 G.H5.26
Ionic ICL1 R 598 12x51 G.HN D 20 G.HN.44
Polar ICL2 S 670 - G.HN E 28 G.HN.52
Hydrophobic ICL2 S 670 - G.HN E 28 G.HN.52
Van-der-waals ICL2 S 670 - G.HN E 28 G.HN.52
Hydrophobic ICL2 F 665 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 665 - G.H5 T 340 G.H5.12
Ionic ICL2 D 669 - G.hns1 K 32 G.hns1.03
Polar ICL2 D 669 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 D 669 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 D 669 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 E 668 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 E 668 - G.hns1 A 31 G.hns1.02
Hydrophobic C-term L 871 - G.H2 R 208 G.H2.04
Hydrophobic TM6 L 765 6x45 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 765 6x45 G.H5 L 353 G.H5.25
Polar TM5 N 745 5x68 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 N 745 5x68 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 N 745 5x68 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 L 657 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 664 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 V 664 - G.H5 I 343 G.H5.15
Hydrophobic TM5 V 734 5x57 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 741 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 I 741 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 F 665 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 F 665 - G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 F 665 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 665 - G.S3 L 194 G.S3.01
Hydrophobic TM3 M 660 3x57 G.H5 E 350 G.H5.22
Van-der-waals TM3 M 660 3x57 G.H5 E 350 G.H5.22
Polar ICL2 E 668 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 E 668 - G.hns1 K 32 G.hns1.03
Hydrophobic TM6 A 761 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 661 3x58 G.H5 L 348 G.H5.20
Hydrophobic H8 E 812 8x49 G.H5 E 350 G.H5.22
Van-der-waals H8 E 812 8x49 G.H5 E 350 G.H5.22
Polar TM5 N 745 5x68 G.H5 Y 354 G.H5.26
Van-der-waals TM5 N 745 5x68 G.H5 Y 354 G.H5.26
Polar TM2 N 599 2x44 G.H5 E 350 G.H5.22
Van-der-waals TM2 N 599 2x44 G.H5 E 350 G.H5.22
Hydrophobic C-term L 871 - G.H2 K 209 G.H2.05
Hydrophobic ICL2 V 664 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 V 664 - G.H5 I 344 G.H5.16