Gs - ADGRE4P complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.4
PAE mean: 18.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 295 - G.HN K 34 G.HN.51
Hydrophobic ICL2 R 295 - G.HN K 34 G.HN.51
Van-der-waals ICL2 R 295 - G.HN K 34 G.HN.51
Hydrophobic ICL3 V 374 - G.H5 I 382 G.H5.14
Hydrophobic ICL2 A 288 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 A 288 - G.S3 V 217 G.S3.01
Polar ICL2 A 288 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 A 288 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 A 288 - G.hns1 A 39 G.hns1.03
Hydrophobic TM3 T 281 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 T 281 3x57 G.H5 Y 391 G.H5.23
Polar H8 N 439 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 N 439 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 439 8x47 G.H5 E 392 G.H5.24
Polar ICL3 N 371 - G.H5 D 378 G.H5.10
Hydrophobic ICL2 L 285 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 L 285 - G.H5 H 387 G.H5.19
Hydrophobic ICL3 I 377 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 I 377 - G.H5 R 385 G.H5.17
Hydrophobic TM3 V 282 3x58 G.H5 L 393 G.H5.25
Van-der-waals TM3 V 282 3x58 G.H5 L 393 G.H5.25
Polar ICL2 A 288 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 A 288 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 A 288 - G.S1 H 41 G.S1.02
Polar ICL3 S 375 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 S 375 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 S 375 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 K 286 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 K 286 - G.S3 V 217 G.S3.01
Polar ICL2 Y 290 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 Y 290 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Y 290 - G.hns1 R 38 G.hns1.02
Van-der-waals TM5 S 369 5x67 G.H5 D 381 G.H5.13
Polar ICL2 N 289 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 N 289 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 N 289 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 R 295 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 N 289 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 N 289 - G.HN Q 35 G.HN.52
Hydrophobic TM2 T 223 2x47 G.H5 E 392 G.H5.24
Hydrophobic ICL3 I 377 - G.H5 L 394 G.H5.26
Hydrophobic ICL2 V 287 - G.hns1 A 39 G.hns1.03
Polar ICL2 R 295 - G.HN Q 31 G.HN.48
Hydrophobic ICL2 R 295 - G.HN Q 31 G.HN.48
Van-der-waals ICL2 R 295 - G.HN Q 31 G.HN.48
Hydrophobic TM5 L 363 5x61 G.H5 L 393 G.H5.25
Aromatic ICL2 Y 290 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 290 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 290 - G.H5 H 387 G.H5.19
Polar TM5 L 370 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 L 370 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 L 370 5x68 G.H5 D 381 G.H5.13
Aromatic ICL2 Y 290 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Y 290 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 Y 290 - G.H5 Y 391 G.H5.23
Ionic TM7 H 435 7x57 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 363 5x61 G.H5 L 388 G.H5.20
Polar TM5 K 366 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 366 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 366 5x64 G.H5 Q 384 G.H5.16
Polar ICL2 R 295 - G.HN L 30 G.HN.47
Hydrophobic H8 R 440 8x48 G.H5 R 389 G.H5.21
Van-der-waals H8 R 440 8x48 G.H5 R 389 G.H5.21
Polar TM6 K 386 6x41 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 386 6x41 G.H5 E 392 G.H5.24
Polar ICL3 N 371 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 N 371 - G.H5 D 381 G.H5.13
Polar ICL2 S 292 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 S 292 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 S 292 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 285 - G.H5 L 388 G.H5.20
Van-der-waals ICL2 L 285 - G.H5 L 388 G.H5.20
Hydrophobic TM5 L 370 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 L 370 5x68 G.H5 R 385 G.H5.17
Polar H8 R 440 8x48 G.h4s6 Y 358 G.h4s6.20
Hydrophobic H8 R 440 8x48 G.h4s6 Y 358 G.h4s6.20
Van-der-waals H8 R 440 8x48 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 S 292 - G.HN Q 35 G.HN.52
Polar ICL2 N 289 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 N 289 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 N 289 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 T 281 3x57 G.H5 L 393 G.H5.25
Van-der-waals TM3 T 281 3x57 G.H5 L 393 G.H5.25
Polar TM6 K 386 6x41 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 386 6x41 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 278 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 L 278 3x54 G.H5 L 393 G.H5.25
Polar ICL3 N 371 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 N 371 - G.H5 R 385 G.H5.17
Hydrophobic H8 L 444 8x52 G.h4s6 G 355 G.h4s6.11
Polar ICL2 A 288 - G.S1 T 40 G.S1.01
Hydrophobic ICL2 A 288 - G.S1 T 40 G.S1.01
Polar ICL2 N 289 - G.HN V 36 G.HN.53
Polar ICL3 V 374 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 V 374 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 V 374 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 V 374 - G.H5 D 378 G.H5.10
Ionic TM2 H 226 2x50 G.H5 E 392 G.H5.24
Polar ICL2 T 291 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 T 291 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 T 291 - G.hns1 R 38 G.hns1.02
Polar ICL2 G 294 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 G 294 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 G 294 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 R 295 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 R 295 - G.HN Q 35 G.HN.52
Hydrophobic TM6 M 383 6x38 G.H5 L 394 G.H5.26
Van-der-waals TM6 M 383 6x38 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 285 - G.H5 Y 391 G.H5.23
Hydrophobic TM6 K 386 6x41 G.H5 L 393 G.H5.25
Hydrophobic ICL2 A 288 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 A 288 - G.hns1 R 38 G.hns1.02