G12 - ADGRE5 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 14.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 644 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 644 - G.H5 I 370 G.H5.15
Hydrophobic ICL2 V 644 - G.H5 L 371 G.H5.16
Van-der-waals ICL2 V 644 - G.H5 L 371 G.H5.16
Hydrophobic ICL2 V 644 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 V 644 - G.H5 K 367 G.H5.12
Hydrophobic TM5 I 725 5x68 G.H5 L 375 G.H5.20
Van-der-waals TM5 I 725 5x68 G.H5 L 375 G.H5.20
Polar ICL3 N 726 - G.H5 Q 381 G.H5.26
Van-der-waals ICL3 N 726 - G.H5 Q 381 G.H5.26
Aromatic ICL2 F 645 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 645 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 645 - G.H5 F 363 G.H5.08
Hydrophobic H8 N 790 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 645 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 645 - G.H5 K 367 G.H5.12
Hydrophobic ICL2 F 645 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 645 - G.H5 I 370 G.H5.15
Hydrophobic TM2 R 579 2x46 G.H5 I 378 G.H5.23
Hydrophobic ICL3 D 728 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 D 728 - G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 T 741 6x41 G.H5 I 378 G.H5.23
Hydrophobic TM5 K 721 5x64 G.H5 L 371 G.H5.16
Hydrophobic ICL3 P 727 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 P 727 - G.h4s6 S 343 G.h4s6.12
Polar ICL2 Q 648 - G.HN R 52 G.HN.52
Hydrophobic ICL2 Q 648 - G.HN R 52 G.HN.52
Van-der-waals ICL2 Q 648 - G.HN R 52 G.HN.52
Hydrophobic TM5 E 724 5x67 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 A 737 6x37 G.H5 M 379 G.H5.24
Polar TM3 L 640 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 640 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 L 640 3x57 G.H5 N 374 G.H5.19
Hydrophobic ICL2 Q 648 - G.hns1 R 55 G.hns1.02
Hydrophobic TM3 V 641 3x58 G.H5 L 375 G.H5.20
Hydrophobic TM3 V 641 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 641 3x58 G.H5 L 371 G.H5.16
Hydrophobic ICL2 F 645 - G.H5 V 366 G.H5.11
Hydrophobic H8 K 791 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 791 8x48 G.H5 Q 381 G.H5.26
Polar TM3 V 642 3x59 G.H5 K 367 G.H5.12
Polar TM4 T 652 4x43 G.HN R 52 G.HN.52
Hydrophobic TM7 H 786 7x57 G.H5 L 380 G.H5.25
Hydrophobic TM5 K 721 5x64 G.H5 L 375 G.H5.20
Hydrophobic ICL2 F 645 - G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 645 - G.S1 V 58 G.S1.02
Hydrophobic TM5 L 718 5x61 G.H5 M 379 G.H5.24
Van-der-waals TM5 L 718 5x61 G.H5 M 379 G.H5.24
Ionic H8 K 792 8x49 G.H5 D 377 G.H5.22
Polar H8 K 792 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 K 792 8x49 G.H5 D 377 G.H5.22
Ionic TM5 K 721 5x64 G.H5 D 368 G.H5.13
Polar TM5 K 721 5x64 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 721 5x64 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 721 5x64 G.H5 D 368 G.H5.13
Polar ICL2 Q 648 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Q 648 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Q 648 - G.hns1 R 56 G.hns1.03
Hydrophobic TM5 I 725 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Q 745 6x45 G.H5 I 378 G.H5.23
Hydrophobic TM6 A 744 6x44 G.H5 L 380 G.H5.25
Hydrophobic TM5 F 722 5x65 G.H5 M 379 G.H5.24
Van-der-waals TM5 F 722 5x65 G.H5 M 379 G.H5.24
Polar TM2 R 579 2x46 G.H5 D 377 G.H5.22
Hydrophobic TM3 L 637 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 637 3x54 G.H5 I 378 G.H5.23
Polar H8 K 791 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 K 791 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM7 L 785 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 785 7x56 G.H5 L 380 G.H5.25
Polar TM6 T 741 6x41 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 741 6x41 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 741 6x41 G.H5 M 379 G.H5.24
Hydrophobic ICL2 F 645 - G.S3 F 223 G.S3.03
Hydrophobic TM3 V 641 3x58 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 641 3x58 G.H5 I 378 G.H5.23
Hydrophobic ICL2 F 645 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 645 - G.S3 I 221 G.S3.01
Polar TM5 I 725 5x68 G.H5 K 376 G.H5.21
Hydrophobic TM5 I 725 5x68 G.H5 K 376 G.H5.21
Van-der-waals TM5 I 725 5x68 G.H5 K 376 G.H5.21
Hydrophobic TM5 I 725 5x68 G.H5 M 379 G.H5.24
Hydrophobic TM5 K 717 5x60 G.H5 L 375 G.H5.20
Hydrophobic TM5 L 718 5x61 G.H5 L 375 G.H5.20
Polar TM5 E 724 5x67 G.H5 Q 372 G.H5.17
Hydrophobic TM5 E 724 5x67 G.H5 Q 372 G.H5.17
Van-der-waals TM5 E 724 5x67 G.H5 Q 372 G.H5.17
Hydrophobic ICL3 P 727 - G.h4s6 K 344 G.h4s6.19
Polar ICL2 V 644 - G.H5 N 374 G.H5.19