Gs - ADGRE5 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 86.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 L 640 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 640 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 640 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM5 K 721 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 640 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 640 3x57 G.H5 Y 391 G.H5.23
Polar TM3 V 641 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 641 3x58 G.H5 Q 384 G.H5.16
Polar TM6 T 741 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 741 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 741 6x41 G.H5 L 393 G.H5.25
Polar ICL2 V 644 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 644 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 V 644 - G.H5 H 387 G.H5.19
Polar ICL2 Q 648 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 Q 648 - G.HN Q 35 G.HN.52
Hydrophobic TM5 I 725 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 725 5x68 G.H5 R 385 G.H5.17
Van-der-waals ICL2 Q 648 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 F 645 - G.S3 F 219 G.S3.03
Ionic TM5 E 724 5x67 G.H5 R 385 G.H5.17
Polar TM5 E 724 5x67 G.H5 R 385 G.H5.17
Van-der-waals TM5 E 724 5x67 G.H5 R 385 G.H5.17
Hydrophobic TM5 I 725 5x68 G.H5 L 394 G.H5.26
Van-der-waals TM5 I 725 5x68 G.H5 L 394 G.H5.26
Polar H8 N 790 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 N 790 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 790 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 V 641 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM6 Q 745 6x45 G.H5 L 393 G.H5.25
Van-der-waals TM6 Q 745 6x45 G.H5 L 393 G.H5.25
Polar H8 K 791 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 791 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 791 8x48 G.H5 E 392 G.H5.24
Polar TM3 E 636 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 636 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 644 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 644 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 645 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 645 - G.H5 I 383 G.H5.15
Hydrophobic TM5 F 722 5x65 G.H5 L 394 G.H5.26
Polar H8 K 792 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 718 5x61 G.H5 L 394 G.H5.26
Aromatic ICL2 F 645 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 645 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 645 - G.S1 H 41 G.S1.02
Hydrophobic TM5 L 718 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 718 5x61 G.H5 L 393 G.H5.25
Polar H8 K 792 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 K 792 8x49 G.H5 Q 390 G.H5.22
Polar TM2 R 579 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 579 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 579 2x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 644 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 644 - G.H5 I 383 G.H5.15
Hydrophobic TM5 K 721 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 721 5x64 G.H5 Q 384 G.H5.16
Aromatic ICL2 F 645 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 645 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 645 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 645 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 645 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 645 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 645 - G.S3 V 217 G.S3.01
Polar ICL2 Q 648 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 Q 648 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Q 648 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 G 647 - G.H5 H 387 G.H5.19
Hydrophobic TM5 L 718 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM5 K 721 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 V 644 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 644 - G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 725 5x68 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 725 5x68 G.h4s6 Y 358 G.h4s6.20
Ionic TM5 K 721 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 721 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 721 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 721 5x64 G.H5 D 381 G.H5.13
Hydrophobic ICL2 F 645 - G.H5 C 379 G.H5.11