G12 - ADGRF1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 686 3x58 G.H5 L 375 G.H5.20
Hydrophobic ICL2 V 689 - G.H5 L 371 G.H5.16
Van-der-waals ICL2 V 689 - G.H5 L 371 G.H5.16
Hydrophobic ICL3 T 773 - G.H5 Q 372 G.H5.17
Hydrophobic TM2 R 623 2x46 G.H5 L 380 G.H5.25
Van-der-waals TM2 R 623 2x46 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 690 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 690 - G.H5 K 367 G.H5.12
Ionic H8 K 844 8x49 G.H5 D 377 G.H5.22
Polar H8 K 844 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 K 844 8x49 G.H5 D 377 G.H5.22
Polar TM6 K 791 6x40 G.H5 L 380 G.H5.25
Van-der-waals TM6 K 791 6x40 G.H5 L 380 G.H5.25
Hydrophobic ICL3 T 773 - G.S6 F 347 G.S6.02
Hydrophobic ICL3 E 776 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 E 776 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 R 685 3x57 G.H5 I 378 G.H5.23
Hydrophobic C-term F 906 - H.HA K 114 H.HA.28
Van-der-waals C-term F 906 - H.HA K 114 H.HA.28
Hydrophobic ICL3 G 775 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 G 775 - G.S6 L 346 G.S6.01
Hydrophobic ICL3 L 778 - G.H4 V 332 G.H4.12
Hydrophobic TM3 L 682 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 682 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 F 690 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 690 - G.H5 I 370 G.H5.15
Hydrophobic TM2 S 620 2x43 G.H5 D 377 G.H5.22
Hydrophobic TM3 I 686 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 686 3x58 G.H5 L 371 G.H5.16
Polar ICL2 H 691 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 691 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 691 - G.hns1 R 56 G.hns1.03
Hydrophobic TM4 A 694 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 A 694 4x38 G.HN R 52 G.HN.52
Hydrophobic TM3 L 682 3x54 G.H5 M 379 G.H5.24
Polar TM6 S 792 6x41 G.H5 Q 381 G.H5.26
Hydrophobic TM7 G 838 7x57 G.H5 L 380 G.H5.25
Van-der-waals TM7 G 838 7x57 G.H5 L 380 G.H5.25
Hydrophobic TM2 T 619 2x42 G.H5 D 377 G.H5.22
Hydrophobic ICL2 F 690 - G.H5 V 366 G.H5.11
Polar ICL2 H 692 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 692 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 L 778 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 L 778 - G.S6 H 348 G.S6.03
Hydrophobic TM2 R 623 2x46 G.H5 D 377 G.H5.22
Van-der-waals TM2 R 623 2x46 G.H5 D 377 G.H5.22
Hydrophobic TM6 I 795 6x44 G.H5 L 380 G.H5.25
Hydrophobic TM6 L 796 6x45 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 796 6x45 G.H5 M 379 G.H5.24
Hydrophobic TM6 K 791 6x40 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 F 690 - G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 690 - G.S1 V 58 G.S1.02
Polar ICL2 H 692 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 H 692 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 H 692 - G.hns1 R 55 G.hns1.02
Aromatic ICL2 F 690 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 690 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 690 - G.H5 F 363 G.H5.08
Hydrophobic TM5 V 765 5x57 G.H5 L 375 G.H5.20
Polar TM2 T 619 2x42 G.H5 N 374 G.H5.19
Hydrophobic ICL3 G 775 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 G 775 - G.S6 F 347 G.S6.02
Polar TM2 Q 618 2x41 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 Q 618 2x41 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 Q 618 2x41 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 L 682 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL3 V 774 - G.S6 F 347 G.S6.02
Polar H8 S 843 8x48 G.H5 L 380 G.H5.25
Polar TM6 R 788 6x37 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 788 6x37 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 788 6x37 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 F 690 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 690 - G.S3 I 221 G.S3.01
Hydrophobic H8 D 842 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 D 842 8x47 G.H5 L 380 G.H5.25
Polar H8 S 843 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 S 843 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 S 843 8x48 G.H5 Q 381 G.H5.26
Polar TM2 R 623 2x46 G.H5 I 378 G.H5.23
Hydrophobic TM2 R 623 2x46 G.H5 I 378 G.H5.23
Van-der-waals TM2 R 623 2x46 G.H5 I 378 G.H5.23
Hydrophobic ICL3 V 774 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 V 774 - G.H5 D 368 G.H5.13
Hydrophobic ICL2 V 689 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 689 - G.H5 I 370 G.H5.15
Hydrophobic TM6 S 792 6x41 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 792 6x41 G.H5 M 379 G.H5.24
Hydrophobic C-term F 906 - H.HA D 113 H.HA.27
Polar TM3 R 685 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 R 685 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 R 685 3x57 G.H5 N 374 G.H5.19
Hydrophobic ICL3 T 773 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 T 773 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 L 769 5x61 G.H5 L 375 G.H5.20
Hydrophobic ICL3 V 774 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 V 774 - G.H5 F 361 G.H5.06
Hydrophobic ICL2 V 689 - G.H5 K 367 G.H5.12
Hydrophobic TM2 T 619 2x42 G.H5 I 378 G.H5.23
Van-der-waals TM2 T 619 2x42 G.H5 I 378 G.H5.23
Van-der-waals TM6 I 795 6x44 G.H5 M 379 G.H5.24
Hydrophobic TM5 K 768 5x60 G.H5 L 371 G.H5.16
Polar TM2 S 617 2x40 G.H5 D 377 G.H5.22
Hydrophobic TM2 S 617 2x40 G.H5 D 377 G.H5.22
Van-der-waals TM2 S 617 2x40 G.H5 D 377 G.H5.22
Polar ICL3 G 775 - G.S6 H 348 G.S6.03