Gt2 - ADGRF4 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 86.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 13.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL1 E 434 - G.HN Q 24 G.HN.48
Hydrophobic ICL1 E 434 - G.HN Q 24 G.HN.48
Van-der-waals ICL1 E 434 - G.HN Q 24 G.HN.48
Hydrophobic ICL2 F 506 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 F 506 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL1 I 435 - G.H5 N 347 G.H5.19
Van-der-waals ICL1 I 435 - G.H5 N 347 G.H5.19
Ionic ICL2 R 507 - G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 507 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 507 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 507 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 F 506 - G.H5 I 343 G.H5.15
Aromatic ICL2 F 506 - G.H5 F 336 G.H5.08
Hydrophobic ICL2 F 506 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 F 506 - G.H5 F 336 G.H5.08
Polar TM6 R 602 6x37 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 602 6x37 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 I 505 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 I 505 - G.H5 T 340 G.H5.12
Hydrophobic ICL3 G 590 - G.H4 L 308 G.H4.16
Van-der-waals ICL3 G 590 - G.H4 L 308 G.H4.16
Hydrophobic ICL1 I 435 - G.H5 D 350 G.H5.22
Hydrophobic TM6 L 610 6x45 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 610 6x45 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 506 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 F 506 - G.s2s3 K 192 G.s2s3.01
Polar TM3 G 501 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 G 501 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 G 501 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM5 V 580 5x57 G.H5 L 353 G.H5.25
Hydrophobic ICL1 I 435 - G.H5 C 351 G.H5.23
Van-der-waals ICL1 I 435 - G.H5 C 351 G.H5.23
Hydrophobic ICL3 S 588 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 S 588 - G.h4s6 E 318 G.h4s6.12
Polar TM6 K 605 6x40 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 605 6x40 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 605 6x40 G.H5 F 354 G.H5.26
Ionic H8 K 658 8x49 G.H5 D 350 G.H5.22
Polar H8 K 658 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 658 8x49 G.H5 D 350 G.H5.22
Polar TM6 N 606 6x41 G.H5 F 354 G.H5.26
Hydrophobic TM6 N 606 6x41 G.H5 F 354 G.H5.26
Van-der-waals TM6 N 606 6x41 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 498 3x54 G.H5 L 348 G.H5.20
Polar H8 K 658 8x49 G.H5 K 349 G.H5.21
Polar ICL3 I 589 - G.S6 S 321 G.S6.03
Hydrophobic ICL3 I 589 - G.S6 S 321 G.S6.03
Van-der-waals ICL3 I 589 - G.S6 S 321 G.S6.03
Ionic TM6 R 602 6x37 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 602 6x37 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 F 506 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 506 - G.S3 L 194 G.S3.01
Aromatic TM6 R 602 6x37 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 602 6x37 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 602 6x37 G.H5 F 354 G.H5.26
Polar ICL1 T 433 - G.H5 D 350 G.H5.22
Hydrophobic ICL1 T 433 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 T 433 - G.H5 D 350 G.H5.22
Hydrophobic TM3 I 502 3x58 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 507 - G.hns1 K 32 G.hns1.03
Hydrophobic TM2 R 439 2x46 G.H5 G 352 G.H5.24
Van-der-waals TM2 R 439 2x46 G.H5 G 352 G.H5.24
Polar TM4 K 511 4x39 G.HN Q 24 G.HN.48
Hydrophobic TM2 R 439 2x46 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 439 2x46 G.H5 D 350 G.H5.22
Hydrophobic ICL3 G 590 - G.H4 K 304 G.H4.12
Van-der-waals ICL3 G 590 - G.H4 K 304 G.H4.12
Hydrophobic TM3 I 498 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL2 I 505 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 I 505 - G.H5 I 344 G.H5.16
Hydrophobic TM5 V 580 5x57 G.H5 L 348 G.H5.20
Hydrophobic TM6 N 606 6x41 G.H5 L 353 G.H5.25
Hydrophobic ICL3 I 589 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 I 589 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 I 589 - G.S6 I 319 G.S6.01
Hydrophobic TM4 M 510 4x38 G.HN Q 24 G.HN.48
Van-der-waals TM4 M 510 4x38 G.HN Q 24 G.HN.48
Ionic TM5 R 586 5x63 G.H5 D 341 G.H5.13
Polar TM5 R 586 5x63 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 498 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 508 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 508 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 I 502 3x58 G.H5 I 344 G.H5.16
Hydrophobic ICL2 I 505 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 I 505 - G.H5 I 343 G.H5.15
Polar TM2 R 439 2x46 G.H5 C 351 G.H5.23
Hydrophobic TM2 R 439 2x46 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 439 2x46 G.H5 C 351 G.H5.23