G12 - ADGRL1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 64.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 12.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL2 E 957 - G.HN R 52 G.HN.52
Hydrophobic C-term M 1152 - G.H3 L 285 G.H3.17
Van-der-waals C-term M 1152 - G.H3 L 285 G.H3.17
Hydrophobic ICL2 F 956 - G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 956 - G.S1 V 58 G.S1.02
Polar H8 Q 1101 8x47 G.H5 D 377 G.H5.22
Polar C-term N 1245 - H.hdhe F 173 H.hdhe.01
Hydrophobic C-term N 1245 - H.hdhe F 173 H.hdhe.01
Van-der-waals C-term N 1245 - H.hdhe F 173 H.hdhe.01
Hydrophobic TM2 T 890 2x44 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 T 890 2x44 G.hns1 R 55 G.hns1.02
Hydrophobic C-term T 1472 - G.HN G 19 G.HN.19
Hydrophobic C-term V 1471 - G.HN A 20 G.HN.20
Polar C-term N 1245 - H.hdhe Q 174 H.hdhe.02
Hydrophobic C-term N 1245 - H.hdhe Q 174 H.hdhe.02
Van-der-waals C-term N 1245 - H.hdhe Q 174 H.hdhe.02
Ionic TM2 D 891 2x45 G.HN R 52 G.HN.52
Polar TM2 D 891 2x45 G.HN R 52 G.HN.52
Van-der-waals TM2 D 891 2x45 G.HN R 52 G.HN.52
Hydrophobic C-term C 1237 - H.HB E 135 H.HB.13
Van-der-waals C-term C 1237 - H.HB E 135 H.HB.13
Hydrophobic C-term L 1474 - G.HN E 16 G.HN.16
Van-der-waals C-term L 1474 - G.HN E 16 G.HN.16
Polar TM3 V 953 3x59 G.H5 K 367 G.H5.12
Van-der-waals TM3 V 953 3x59 G.H5 K 367 G.H5.12
Polar C-term S 1473 - G.HN A 20 G.HN.20
Hydrophobic C-term S 1473 - G.HN A 20 G.HN.20
Van-der-waals C-term S 1473 - G.HN A 20 G.HN.20
Polar C-term S 1164 - G.H2 R 232 G.H2.01
Hydrophobic C-term S 1164 - G.H2 R 232 G.H2.01
Polar C-term T 1472 - G.HN A 20 G.HN.20
Hydrophobic C-term I 1149 - G.H2 F 239 G.H2.08
Van-der-waals C-term I 1149 - G.H2 F 239 G.H2.08
Polar TM3 L 951 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 951 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 L 951 3x57 G.H5 N 374 G.H5.19
Polar C-term L 1474 - G.HN A 17 G.HN.17
Hydrophobic C-term L 1474 - G.HN A 17 G.HN.17
Van-der-waals C-term L 1474 - G.HN A 17 G.HN.17
Polar TM5 L 1036 5x68 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 L 1036 5x68 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 L 1036 5x68 G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term R 1150 - G.H2 F 239 G.H2.08
Van-der-waals C-term R 1150 - G.H2 F 239 G.H2.08
Hydrophobic H8 S 1115 8x61 G.HN T 7 G.HN.07
Hydrophobic C-term W 1153 - G.H2 Q 236 G.H2.05
Hydrophobic TM5 L 1036 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 L 1036 5x68 G.H5 Q 372 G.H5.17
Polar C-term T 1241 - H.HA K 114 H.HA.28
Hydrophobic C-term T 1241 - H.HA K 114 H.HA.28
Van-der-waals C-term T 1241 - H.HA K 114 H.HA.28
Hydrophobic H8 K 1102 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 1102 8x48 G.H5 Q 381 G.H5.26
Hydrophobic C-term W 1153 - G.H2 F 239 G.H2.08
Hydrophobic ICL2 V 955 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 V 955 - G.H5 K 367 G.H5.12
Polar C-term P 1243 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term P 1243 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term P 1243 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term W 1153 - G.H3 I 280 G.H3.12
Van-der-waals C-term W 1153 - G.H3 I 280 G.H3.12
Aromatic ICL2 F 956 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 956 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 956 - G.H5 F 363 G.H5.08
Polar TM6 S 1048 6x37 G.H5 Q 381 G.H5.26
Van-der-waals TM6 S 1048 6x37 G.H5 Q 381 G.H5.26
Polar C-term W 1153 - G.H2 R 235 G.H2.04
Van-der-waals C-term W 1153 - G.H2 R 235 G.H2.04
Hydrophobic C-term T 1156 - G.H3 T 279 G.H3.11
Van-der-waals C-term T 1156 - G.H3 T 279 G.H3.11
Hydrophobic TM6 G 1052 6x41 G.H5 M 379 G.H5.24
Hydrophobic C-term I 1119 - G.HN T 7 G.HN.07
Polar C-term Q 1160 - G.H2 R 235 G.H2.04
Van-der-waals C-term Q 1160 - G.H2 R 235 G.H2.04
Hydrophobic C-term I 1149 - G.h2s4 F 242 G.h2s4.01
Van-der-waals C-term I 1149 - G.h2s4 F 242 G.h2s4.01
Polar C-term N 1245 - H.HD E 172 H.HD.12
Hydrophobic C-term N 1245 - H.HD E 172 H.HD.12
Van-der-waals C-term N 1245 - H.HD E 172 H.HD.12
Hydrophobic C-term S 1473 - G.HN G 18 G.HN.18
Van-der-waals C-term S 1473 - G.HN G 18 G.HN.18
Polar C-term S 1473 - G.HN G 19 G.HN.19
Hydrophobic C-term S 1473 - G.HN G 19 G.HN.19
Van-der-waals C-term S 1473 - G.HN G 19 G.HN.19
Hydrophobic C-term L 1244 - H.HA K 114 H.HA.28
Hydrophobic TM7 F 1096 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 1096 7x56 G.H5 L 380 G.H5.25
Hydrophobic C-term Y 1252 - H.HA K 114 H.HA.28
Van-der-waals C-term Y 1252 - H.HA K 114 H.HA.28
Aromatic C-term W 1153 - G.h2s4 F 242 G.h2s4.01
Hydrophobic C-term W 1153 - G.h2s4 F 242 G.h2s4.01
Van-der-waals C-term W 1153 - G.h2s4 F 242 G.h2s4.01
Hydrophobic C-term L 1242 - H.HA V 107 H.HA.21
Van-der-waals C-term L 1242 - H.HA V 107 H.HA.21
Hydrophobic C-term V 1157 - G.H2 Q 236 G.H2.05
Hydrophobic ICL2 V 955 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 955 - G.H5 I 370 G.H5.15
Polar C-term N 1245 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term N 1245 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term N 1245 - G.s4h3 V 260 G.s4h3.07
Van-der-waals C-term N 1245 - G.s4h3 V 260 G.s4h3.07
Hydrophobic C-term W 1153 - G.H3 T 279 G.H3.11
Van-der-waals C-term W 1153 - G.H3 T 279 G.H3.11
Ionic H8 K 1103 8x49 G.H5 D 377 G.H5.22
Polar H8 K 1103 8x49 G.H5 D 377 G.H5.22
Hydrophobic H8 K 1103 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 K 1103 8x49 G.H5 D 377 G.H5.22
Polar ICL2 V 955 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 S 958 - G.hns1 R 56 G.hns1.03
Hydrophobic C-term V 1157 - G.H2 R 235 G.H2.04
Hydrophobic TM3 L 951 3x57 G.H5 I 378 G.H5.23
Hydrophobic TM5 M 1029 5x61 G.H5 M 379 G.H5.24
Van-der-waals TM5 M 1029 5x61 G.H5 M 379 G.H5.24
Van-der-waals C-term L 1244 - H.HD E 172 H.HD.12
Polar H8 C 1111 8x57 G.HN C 11 G.HN.11
Hydrophobic H8 C 1111 8x57 G.HN C 11 G.HN.11
Van-der-waals H8 C 1111 8x57 G.HN C 11 G.HN.11
Polar ICL1 G 887 12x49 G.HN R 51 G.HN.51
Van-der-waals ICL1 G 887 12x49 G.HN R 51 G.HN.51
Polar C-term Q 1160 - G.H3 E 272 G.H3.04
Polar C-term Q 1160 - G.H3 N 275 G.H3.07
Hydrophobic C-term Q 1160 - G.H3 N 275 G.H3.07
Van-der-waals C-term Q 1160 - G.H3 N 275 G.H3.07
Polar C-term N 1247 - G.s4h3 R 266 G.s4h3.13
Van-der-waals C-term N 1247 - G.s4h3 R 266 G.s4h3.13
Polar ICL1 Q 889 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 S 1048 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 1048 6x37 G.H5 M 379 G.H5.24
Hydrophobic TM6 L 1056 6x45 G.H5 I 378 G.H5.23
Hydrophobic C-term L 1244 - H.hdhe F 173 H.hdhe.01
Hydrophobic C-term T 1161 - G.H2 R 232 G.H2.01
Polar TM2 R 892 2x46 G.H5 D 377 G.H5.22
Hydrophobic ICL2 F 956 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 956 - G.H5 I 370 G.H5.15
Hydrophobic C-term L 1244 - H.HA L 115 H.HA.29
Van-der-waals C-term L 1244 - H.HA L 115 H.HA.29
Hydrophobic H8 Y 1108 8x54 G.HN L 8 G.HN.08
Hydrophobic C-term Q 1160 - G.H3 I 276 G.H3.08
Van-der-waals C-term Q 1160 - G.H3 I 276 G.H3.08
Hydrophobic TM3 L 952 3x58 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 952 3x58 G.H5 L 375 G.H5.20
Hydrophobic ICL2 F 956 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 956 - G.S3 I 221 G.S3.01
Hydrophobic TM5 S 1032 5x64 G.H5 L 375 G.H5.20
Van-der-waals TM5 S 1032 5x64 G.H5 L 375 G.H5.20
Hydrophobic C-term Y 1142 - G.h2s4 D 243 G.h2s4.02
Van-der-waals C-term Y 1142 - G.h2s4 D 243 G.h2s4.02
Hydrophobic C-term I 1149 - G.H3 L 285 G.H3.17
Hydrophobic TM1 F 884 1x63 G.HN L 12 G.HN.12
Van-der-waals TM1 F 884 1x63 G.HN L 12 G.HN.12
Polar C-term L 1242 - H.HA K 114 H.HA.28
Van-der-waals C-term L 1242 - H.HA K 114 H.HA.28
Hydrophobic ICL2 Y 960 - G.HN R 52 G.HN.52
Hydrophobic TM7 L 1100 7x60 G.H5 L 380 G.H5.25
Polar C-term L 1242 - H.HA D 110 H.HA.24
Hydrophobic C-term L 1242 - H.HA D 110 H.HA.24
Van-der-waals C-term L 1242 - H.HA D 110 H.HA.24
Polar ICL1 Q 889 12x51 G.HN R 51 G.HN.51
Van-der-waals ICL1 Q 889 12x51 G.HN R 51 G.HN.51
Hydrophobic ICL2 E 959 - G.HN R 52 G.HN.52
Ionic ICL2 E 957 - G.hns1 R 55 G.hns1.02
Polar ICL2 E 957 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 E 957 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 E 957 - G.hns1 R 55 G.hns1.02
Hydrophobic TM3 L 952 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 952 3x58 G.H5 L 371 G.H5.16
Polar C-term L 1244 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term L 1244 - G.s4h3 R 265 G.s4h3.12
Polar C-term L 1474 - G.HN G 19 G.HN.19
Van-der-waals C-term L 1474 - G.HN G 19 G.HN.19
Polar ICL2 E 957 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 E 957 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 E 957 - G.hns1 R 56 G.hns1.03
Hydrophobic H8 C 1111 8x57 G.HN L 8 G.HN.08
Polar C-term L 1474 - G.HN G 18 G.HN.18
Hydrophobic C-term L 1474 - G.HN G 18 G.HN.18
Van-der-waals C-term L 1474 - G.HN G 18 G.HN.18
Hydrophobic TM3 L 948 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 948 3x54 G.H5 I 378 G.H5.23
Ionic ICL2 E 959 - G.hns1 R 56 G.hns1.03
Polar ICL2 E 959 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 E 959 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 E 959 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 F 956 - G.H5 K 367 G.H5.12
Hydrophobic C-term W 1153 - G.H2 W 238 G.H2.07
Van-der-waals C-term W 1153 - G.H2 W 238 G.H2.07
Polar ICL2 S 961 - G.HN R 52 G.HN.52
Hydrophobic ICL2 S 961 - G.HN R 52 G.HN.52
Van-der-waals ICL2 S 961 - G.HN R 52 G.HN.52
Hydrophobic ICL2 V 955 - G.H5 L 371 G.H5.16
Van-der-waals ICL2 V 955 - G.H5 L 371 G.H5.16
Hydrophobic H8 Q 1101 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 Q 1101 8x47 G.H5 L 380 G.H5.25
Hydrophobic C-term M 1152 - G.H3 N 283 G.H3.15
Van-der-waals C-term M 1152 - G.H3 N 283 G.H3.15
Polar C-term G 1246 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term G 1246 - G.s4h3 R 265 G.s4h3.12
Van-der-waals ICL3 K 1037 - G.h4s6 S 343 G.h4s6.12
Polar C-term Q 1146 - G.H2 Q 240 G.H2.09
Hydrophobic C-term M 1239 - H.HB M 132 H.HB.10
Van-der-waals C-term M 1239 - H.HB M 132 H.HB.10
Polar C-term N 1245 - H.HD S 171 H.HD.11
Van-der-waals C-term N 1245 - H.HD S 171 H.HD.11
Hydrophobic TM5 M 1029 5x61 G.H5 L 375 G.H5.20
Van-der-waals TM5 M 1029 5x61 G.H5 L 375 G.H5.20
Van-der-waals ICL2 S 958 - G.HN R 52 G.HN.52