G12 - ADGRL3 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 66.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 12.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 M 955 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 M 955 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 M 955 3x57 G.H5 N 374 G.H5.19
Hydrophobic ICL2 F 960 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 960 - G.H5 I 370 G.H5.15
Hydrophobic TM3 L 952 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 952 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM5 M 1033 5x61 G.H5 I 378 G.H5.23
Hydrophobic C-term S 1395 - H.HA D 110 H.HA.24
Ionic H8 K 1107 8x49 G.H5 D 377 G.H5.22
Polar H8 K 1107 8x49 G.H5 D 377 G.H5.22
Hydrophobic H8 K 1107 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 K 1107 8x49 G.H5 D 377 G.H5.22
Polar ICL3 E 1043 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL3 E 1043 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 E 1043 - G.h4s6 R 342 G.h4s6.11
Hydrophobic TM3 L 956 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 956 3x58 G.H5 L 371 G.H5.16
Hydrophobic TM3 L 956 3x58 G.H5 I 378 G.H5.23
Hydrophobic C-term T 1159 - G.H3 T 279 G.H3.11
Van-der-waals C-term T 1159 - G.H3 T 279 G.H3.11
Hydrophobic C-term M 1396 - H.HA A 111 H.HA.25
Van-der-waals C-term M 1396 - H.HA A 111 H.HA.25
Polar ICL1 Q 893 12x51 G.hns1 R 55 G.hns1.02
Polar TM6 S 1052 6x37 G.H5 Q 381 G.H5.26
Van-der-waals TM6 S 1052 6x37 G.H5 Q 381 G.H5.26
Hydrophobic TM5 K 1032 5x60 G.H5 L 375 G.H5.20
Hydrophobic ICL2 F 960 - G.S1 V 58 G.S1.02
Polar C-term M 1396 - H.HA K 114 H.HA.28
Hydrophobic C-term M 1396 - H.HA K 114 H.HA.28
Van-der-waals C-term M 1396 - H.HA K 114 H.HA.28
Hydrophobic C-term M 1155 - G.H3 L 285 G.H3.17
Hydrophobic TM6 L 1060 6x45 G.H5 I 378 G.H5.23
Polar ICL1 Q 893 12x51 G.HN R 51 G.HN.51
Hydrophobic ICL2 V 959 - G.H5 L 371 G.H5.16
Van-der-waals ICL2 V 959 - G.H5 L 371 G.H5.16
Polar C-term W 1156 - G.H2 R 235 G.H2.04
Van-der-waals C-term W 1156 - G.H2 R 235 G.H2.04
Polar ICL2 E 961 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 E 961 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 E 961 - G.hns1 R 56 G.hns1.03
Polar TM6 S 1052 6x37 G.H5 M 379 G.H5.24
Ionic ICL2 E 961 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 E 961 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 E 961 - G.hns1 R 55 G.hns1.02
Ionic TM5 H 1036 5x64 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 1036 5x64 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 1036 5x64 G.H5 D 368 G.H5.13
Ionic ICL2 E 961 - G.HN R 52 G.HN.52
Polar ICL2 E 961 - G.HN R 52 G.HN.52
Hydrophobic ICL2 E 961 - G.HN R 52 G.HN.52
Van-der-waals ICL2 E 961 - G.HN R 52 G.HN.52
Ionic TM2 D 895 2x45 G.HN R 52 G.HN.52
Polar TM2 D 895 2x45 G.HN R 52 G.HN.52
Van-der-waals TM2 D 895 2x45 G.HN R 52 G.HN.52
Polar TM3 E 958 3x60 G.H5 K 367 G.H5.12
Hydrophobic TM3 E 958 3x60 G.H5 K 367 G.H5.12
Hydrophobic C-term M 1155 - G.H3 N 283 G.H3.15
Van-der-waals C-term M 1155 - G.H3 N 283 G.H3.15
Polar C-term Q 1163 - G.H3 T 279 G.H3.11
Hydrophobic C-term Q 1163 - G.H3 T 279 G.H3.11
Van-der-waals C-term Q 1163 - G.H3 T 279 G.H3.11
Hydrophobic TM5 L 1040 5x68 G.H5 L 375 G.H5.20
Hydrophobic TM5 T 1037 5x65 G.H5 M 379 G.H5.24
Van-der-waals TM5 T 1037 5x65 G.H5 M 379 G.H5.24
Hydrophobic C-term K 1394 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term K 1394 - G.s4h3 M 262 G.s4h3.09
Hydrophobic C-term N 1398 - H.HA K 114 H.HA.28
Van-der-waals C-term N 1398 - H.HA K 114 H.HA.28
Hydrophobic TM6 A 1059 6x44 G.H5 L 380 G.H5.25
Hydrophobic C-term W 1156 - G.H3 I 280 G.H3.12
Van-der-waals C-term W 1156 - G.H3 I 280 G.H3.12
Hydrophobic TM5 L 1040 5x68 G.H5 K 376 G.H5.21
Van-der-waals TM5 L 1040 5x68 G.H5 K 376 G.H5.21
Hydrophobic TM6 G 1056 6x41 G.H5 M 379 G.H5.24
Hydrophobic C-term Y 1392 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term Y 1392 - G.s4h3 M 262 G.s4h3.09
Hydrophobic TM2 R 896 2x46 G.H5 I 378 G.H5.23
Ionic C-term E 1389 - G.hfs2 K 209 G.hfs2.06
Hydrophobic TM6 W 1053 6x38 G.H5 M 379 G.H5.24
Hydrophobic TM5 L 1040 5x68 G.H5 M 379 G.H5.24
Polar C-term K 1394 - H.hdhe Q 174 H.hdhe.02
Hydrophobic C-term K 1394 - H.hdhe Q 174 H.hdhe.02
Van-der-waals C-term K 1394 - H.hdhe Q 174 H.hdhe.02
Polar H8 Q 1105 8x47 G.H5 D 377 G.H5.22
Van-der-waals H8 Q 1105 8x47 G.H5 D 377 G.H5.22
Hydrophobic C-term P 1397 - H.HA K 114 H.HA.28
Van-der-waals C-term P 1397 - H.HA K 114 H.HA.28
Hydrophobic TM3 L 956 3x58 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 956 3x58 G.H5 L 375 G.H5.20
Hydrophobic C-term W 1156 - G.H2 F 239 G.H2.08
Polar ICL3 E 1043 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL3 E 1043 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 E 1043 - G.h4s6 S 343 G.h4s6.12
Hydrophobic TM5 H 1036 5x64 G.H5 L 375 G.H5.20
Van-der-waals TM5 H 1036 5x64 G.H5 L 375 G.H5.20
Polar C-term Q 1163 - G.H3 N 275 G.H3.07
Hydrophobic C-term Q 1163 - G.H3 N 275 G.H3.07
Van-der-waals C-term Q 1163 - G.H3 N 275 G.H3.07
Hydrophobic TM5 L 1040 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 L 1040 5x68 G.H5 Q 372 G.H5.17
Hydrophobic C-term V 1160 - G.H2 Q 236 G.H2.05
Polar TM3 V 957 3x59 G.H5 K 367 G.H5.12
Hydrophobic TM3 V 957 3x59 G.H5 K 367 G.H5.12
Van-der-waals TM3 V 957 3x59 G.H5 K 367 G.H5.12
Hydrophobic TM5 I 1039 5x67 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 I 1039 5x67 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 E 963 - G.HN R 52 G.HN.52
Hydrophobic TM5 H 1036 5x64 G.H5 L 371 G.H5.16
Van-der-waals TM5 H 1036 5x64 G.H5 L 371 G.H5.16
Hydrophobic ICL2 F 960 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 960 - G.S3 I 221 G.S3.01
Hydrophobic TM5 M 1033 5x61 G.H5 M 379 G.H5.24
Van-der-waals TM5 M 1033 5x61 G.H5 M 379 G.H5.24
Van-der-waals ICL2 S 962 - G.HN R 52 G.HN.52
Hydrophobic C-term Q 1163 - G.H3 I 276 G.H3.08
Van-der-waals C-term Q 1163 - G.H3 I 276 G.H3.08
Hydrophobic C-term I 1152 - G.H2 F 239 G.H2.08
Van-der-waals TM5 L 1040 5x68 G.h4s6 S 343 G.h4s6.12
Hydrophobic C-term W 1156 - G.H2 W 238 G.H2.07
Van-der-waals C-term W 1156 - G.H2 W 238 G.H2.07
Hydrophobic TM7 H 1101 7x57 G.H5 L 380 G.H5.25
Polar C-term S 1395 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term S 1395 - G.s4h3 R 265 G.s4h3.12
Hydrophobic ICL2 S 962 - G.hns1 R 56 G.hns1.03
Aromatic ICL2 F 960 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 960 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 960 - G.H5 F 363 G.H5.08
Polar C-term M 1396 - H.HA D 110 H.HA.24
Van-der-waals C-term M 1396 - H.HA D 110 H.HA.24
Polar H8 K 1106 8x48 G.H5 L 380 G.H5.25
Hydrophobic ICL3 P 1042 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 P 1042 - G.h4s6 S 343 G.h4s6.12
Polar ICL2 H 964 - G.HN R 52 G.HN.52
Hydrophobic ICL2 H 964 - G.HN R 52 G.HN.52
Ionic TM2 R 896 2x46 G.H5 D 377 G.H5.22
Polar TM2 R 896 2x46 G.H5 D 377 G.H5.22
Hydrophobic TM7 F 1100 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 1100 7x56 G.H5 L 380 G.H5.25
Polar ICL2 V 959 - G.H5 N 374 G.H5.19
Aromatic C-term W 1156 - G.h2s4 F 242 G.h2s4.01
Hydrophobic C-term W 1156 - G.h2s4 F 242 G.h2s4.01
Van-der-waals C-term W 1156 - G.h2s4 F 242 G.h2s4.01
Polar C-term Y 1393 - H.HA R 106 H.HA.20
Hydrophobic C-term Y 1393 - H.HA R 106 H.HA.20
Van-der-waals C-term Y 1393 - H.HA R 106 H.HA.20
Ionic C-term K 1394 - G.s1h1 E 67 G.s1h1.04
Polar C-term K 1394 - G.s1h1 E 67 G.s1h1.04
Polar C-term Q 1149 - G.H2 Q 240 G.H2.09
Van-der-waals C-term Q 1149 - G.H2 Q 240 G.H2.09
Hydrophobic TM3 M 955 3x57 G.H5 I 378 G.H5.23
Hydrophobic C-term M 1396 - H.HA L 115 H.HA.29
Polar ICL2 S 965 - G.HN R 52 G.HN.52
Hydrophobic ICL2 S 965 - G.HN R 52 G.HN.52
Van-der-waals ICL2 S 965 - G.HN R 52 G.HN.52
Hydrophobic ICL2 F 960 - G.H5 K 367 G.H5.12
Hydrophobic H8 Q 1105 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM6 I 1055 6x40 G.H5 L 380 G.H5.25
Hydrophobic H8 K 1106 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 1106 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM5 M 1033 5x61 G.H5 L 375 G.H5.20
Van-der-waals TM5 M 1033 5x61 G.H5 L 375 G.H5.20
Hydrophobic ICL2 V 959 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 959 - G.H5 I 370 G.H5.15
Hydrophobic ICL3 K 1041 - G.H5 Q 381 G.H5.26
Van-der-waals ICL3 K 1041 - G.H5 Q 381 G.H5.26
Hydrophobic C-term W 1156 - G.H3 T 279 G.H3.11
Van-der-waals C-term W 1156 - G.H3 T 279 G.H3.11
Hydrophobic C-term L 1399 - H.HA K 114 H.HA.28
Van-der-waals C-term L 1399 - H.HA K 114 H.HA.28
Hydrophobic C-term I 1152 - G.H3 L 285 G.H3.17
Van-der-waals C-term I 1152 - G.H3 L 285 G.H3.17
Hydrophobic C-term M 1396 - H.hdhe F 173 H.hdhe.01
Van-der-waals C-term M 1396 - H.hdhe F 173 H.hdhe.01
Hydrophobic ICL2 V 959 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 V 959 - G.H5 K 367 G.H5.12
Hydrophobic ICL2 F 960 - G.H5 V 366 G.H5.11
Hydrophobic TM7 L 1104 7x60 G.H5 L 380 G.H5.25
Hydrophobic C-term I 1152 - G.h2s4 F 242 G.h2s4.01
Van-der-waals C-term I 1152 - G.h2s4 F 242 G.h2s4.01
Hydrophobic TM5 K 1032 5x60 G.H5 L 371 G.H5.16
Polar C-term Q 1163 - G.H2 R 235 G.H2.04
Van-der-waals C-term Q 1163 - G.H2 R 235 G.H2.04
Hydrophobic C-term R 1153 - G.H2 F 239 G.H2.08
Van-der-waals C-term R 1153 - G.H2 F 239 G.H2.08
Ionic ICL2 E 963 - G.hns1 R 56 G.hns1.03
Polar ICL2 E 963 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 E 963 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 E 963 - G.hns1 R 56 G.hns1.03