Gs - ADGRV1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 74.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 22.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 V 6095 - G.H5 Q 384 G.H5.16
Van-der-waals ICL3 V 6095 - G.H5 Q 384 G.H5.16
Hydrophobic TM7 Y 6152 7x57 G.H5 L 394 G.H5.26
Van-der-waals TM7 Y 6152 7x57 G.H5 L 394 G.H5.26
Hydrophobic C-term M 6206 - G.h4s6 G 355 G.h4s6.11
Hydrophobic C-term I 6299 - G.S2 E 209 G.S2.03
Van-der-waals C-term I 6299 - G.S2 E 209 G.S2.03
Polar C-term R 6298 - G.hfs2 S 205 G.hfs2.06
Van-der-waals C-term R 6298 - G.hfs2 S 205 G.hfs2.06
Hydrophobic TM2 A 5938 2x47 G.H5 L 394 G.H5.26
Hydrophobic TM5 Y 6092 5x66 G.H5 L 388 G.H5.20
Van-der-waals TM5 Y 6092 5x66 G.H5 L 388 G.H5.20
Polar ICL2 H 6005 - G.h3s5 T 284 G.h3s5.02
Hydrophobic ICL2 H 6005 - G.h3s5 T 284 G.h3s5.02
Van-der-waals ICL2 H 6005 - G.h3s5 T 284 G.h3s5.02
Hydrophobic TM2 A 5937 2x46 G.H5 L 394 G.H5.26
Polar TM6 N 6101 6x35 G.H5 Y 391 G.H5.23
Hydrophobic TM6 N 6101 6x35 G.H5 Y 391 G.H5.23
Van-der-waals TM6 N 6101 6x35 G.H5 Y 391 G.H5.23
Hydrophobic TM3 V 5998 3x57 G.H5 Q 390 G.H5.22
Van-der-waals TM3 V 5998 3x57 G.H5 Q 390 G.H5.22
Hydrophobic ICL3 F 6096 - G.H5 L 388 G.H5.20
Van-der-waals ICL3 F 6096 - G.H5 L 388 G.H5.20
Polar TM5 Y 6092 5x66 G.hns1 A 39 G.hns1.03
Polar TM2 A 5937 2x46 G.H5 L 393 G.H5.25
Hydrophobic TM2 A 5937 2x46 G.H5 L 393 G.H5.25
Van-der-waals TM2 A 5937 2x46 G.H5 L 393 G.H5.25
Polar TM5 Y 6092 5x66 G.S1 H 41 G.S1.02
Hydrophobic TM5 Y 6092 5x66 G.S1 H 41 G.S1.02
Van-der-waals TM5 Y 6092 5x66 G.S1 H 41 G.S1.02
Hydrophobic C-term I 6262 - G.H3 R 280 G.H3.16
Polar TM3 M 6001 3x60 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 M 6001 3x60 G.hns1 R 38 G.hns1.02
Van-der-waals TM3 M 6001 3x60 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 V 6085 5x59 G.HN Q 35 G.HN.52
Hydrophobic TM5 Q 6088 5x62 G.hns1 A 39 G.hns1.03
Van-der-waals TM5 Q 6088 5x62 G.hns1 A 39 G.hns1.03
Polar TM3 V 6000 3x59 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 V 6000 3x59 G.hns1 R 38 G.hns1.02
Van-der-waals TM3 V 6000 3x59 G.hns1 R 38 G.hns1.02
Polar ICL2 N 6002 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 N 6002 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 N 6002 - G.H5 H 387 G.H5.19
Hydrophobic TM6 I 6105 6x39 G.H5 L 393 G.H5.25
Van-der-waals TM6 I 6105 6x39 G.H5 L 393 G.H5.25
Hydrophobic ICL3 F 6096 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 F 6096 - G.H5 R 385 G.H5.17
Hydrophobic C-term L 6265 - G.H2 I 235 G.H2.08
Van-der-waals C-term L 6265 - G.H2 I 235 G.H2.08
Ionic ICL2 E 6004 - G.H5 H 387 G.H5.19
Polar ICL2 E 6004 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 E 6004 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 E 6004 - G.H5 H 387 G.H5.19
Hydrophobic C-term I 6262 - G.H3 W 281 G.H3.17
Van-der-waals C-term I 6262 - G.H3 W 281 G.H3.17
Hydrophobic C-term M 6206 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals C-term M 6206 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 L 5999 3x58 G.H5 Y 391 G.H5.23
Hydrophobic TM2 M 5935 2x44 G.H5 L 393 G.H5.25
Hydrophobic C-term I 6262 - G.H2 I 235 G.H2.08
Van-der-waals C-term I 6262 - G.H2 I 235 G.H2.08
Hydrophobic C-term L 6296 - G.H1 R 61 G.H1.09
Polar C-term T 6304 - G.H2 Q 236 G.H2.09
Hydrophobic C-term S 6198 - G.hgh4 T 325 G.hgh4.15
Ionic C-term D 6259 - G.H3 R 280 G.H3.16
Polar C-term D 6259 - G.H3 R 280 G.H3.16
Van-der-waals C-term D 6259 - G.H3 R 280 G.H3.16
Polar ICL2 R 6008 - G.h3s5 T 284 G.h3s5.02
Hydrophobic ICL2 R 6008 - G.h3s5 T 284 G.h3s5.02
Van-der-waals ICL2 R 6008 - G.h3s5 T 284 G.h3s5.02
Polar TM5 Y 6092 5x66 G.H5 H 387 G.H5.19
Aromatic TM5 Y 6092 5x66 G.H5 H 387 G.H5.19
Hydrophobic TM5 Y 6092 5x66 G.H5 H 387 G.H5.19
Van-der-waals TM5 Y 6092 5x66 G.H5 H 387 G.H5.19
Hydrophobic ICL2 E 6004 - G.H5 M 386 G.H5.18
Hydrophobic H8 H 6156 8x47 G.H5 L 394 G.H5.26
Hydrophobic H8 M 6171 8x62 G.H5 R 374 G.H5.06
Van-der-waals H8 M 6171 8x62 G.H5 R 374 G.H5.06
Polar ICL2 E 6004 - G.H5 Q 390 G.H5.22
Hydrophobic ICL2 E 6004 - G.H5 Q 390 G.H5.22
Van-der-waals ICL2 E 6004 - G.H5 Q 390 G.H5.22
Hydrophobic TM2 L 5941 2x50 G.H5 L 394 G.H5.26
Van-der-waals TM2 L 5941 2x50 G.H5 L 394 G.H5.26
Hydrophobic C-term I 6301 - G.H2 Q 236 G.H2.09
Van-der-waals C-term I 6301 - G.H2 Q 236 G.H2.09
Van-der-waals TM6 N 6101 6x35 G.H5 L 393 G.H5.25
Hydrophobic ICL3 F 6096 - G.H5 Q 384 G.H5.16
Van-der-waals ICL3 F 6096 - G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 5998 3x57 G.H5 L 393 G.H5.25
Hydrophobic TM2 M 5935 2x44 G.H5 E 392 G.H5.24
Van-der-waals TM2 M 5935 2x44 G.H5 E 392 G.H5.24
Polar ICL3 R 6099 - G.H5 L 394 G.H5.26
Van-der-waals ICL3 R 6099 - G.H5 L 394 G.H5.26
Hydrophobic TM6 I 6108 6x42 G.H5 L 394 G.H5.26
Van-der-waals TM6 I 6108 6x42 G.H5 L 394 G.H5.26
Hydrophobic C-term L 6202 - G.S6 P 361 G.S6.03
Hydrophobic TM3 M 6001 3x60 G.HN K 34 G.HN.51
Hydrophobic C-term N 6201 - G.hgh4 D 323 G.hgh4.13
Van-der-waals C-term N 6201 - G.hgh4 D 323 G.hgh4.13
Hydrophobic C-term L 6296 - G.S2 E 209 G.S2.03
Van-der-waals C-term L 6296 - G.S2 E 209 G.S2.03
Polar ICL2 N 6002 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 N 6002 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 N 6002 - G.H5 Y 391 G.H5.23
Polar ICL2 N 6002 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 N 6002 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 N 6002 - G.hns1 R 38 G.hns1.02
Hydrophobic C-term V 6294 - G.h1ha V 65 G.h1ha.01
Van-der-waals C-term V 6294 - G.h1ha V 65 G.h1ha.01
Hydrophobic TM3 L 5999 3x58 G.H5 L 393 G.H5.25
Hydrophobic TM5 Y 6092 5x66 G.H5 Q 384 G.H5.16
Hydrophobic C-term K 6266 - G.H3 W 281 G.H3.17
Van-der-waals C-term K 6266 - G.H3 W 281 G.H3.17
Hydrophobic TM3 F 5995 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 F 5995 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM2 M 5935 2x44 G.H5 R 389 G.H5.21
Van-der-waals TM2 M 5935 2x44 G.H5 R 389 G.H5.21
Polar TM5 H 6081 5x55 G.HN Q 35 G.HN.52
Van-der-waals TM5 H 6081 5x55 G.HN Q 35 G.HN.52
Hydrophobic H8 Y 6167 8x58 G.H5 R 385 G.H5.17
Van-der-waals H8 Y 6167 8x58 G.H5 R 385 G.H5.17
Hydrophobic C-term L 6261 - G.H2 R 232 G.H2.05
Polar TM3 V 5998 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM3 V 5998 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 V 5998 3x57 G.H5 Y 391 G.H5.23
Hydrophobic C-term K 6197 - G.hgh4 T 325 G.hgh4.15
Polar TM2 A 5938 2x47 G.H5 L 393 G.H5.25
Van-der-waals TM2 A 5938 2x47 G.H5 L 393 G.H5.25
Hydrophobic C-term F 6258 - G.H3 N 279 G.H3.15
Van-der-waals C-term F 6258 - G.H3 N 279 G.H3.15