GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 74.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 22.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | N | 6002 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | N | 6002 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | N | 6002 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM2 | M | 5935 | 2x44 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM2 | L | 5941 | 2x50 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM2 | L | 5941 | 2x50 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM3 | F | 5995 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | F | 5995 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM2 | M | 5935 | 2x44 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | TM2 | M | 5935 | 2x44 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | C-term | L | 6202 | - | G.S6 | P | 361 | G.S6.03 |
Hydrophobic | H8 | M | 6171 | 8x62 | G.H5 | R | 374 | G.H5.06 |
Van-der-waals | H8 | M | 6171 | 8x62 | G.H5 | R | 374 | G.H5.06 |
Polar | TM5 | Y | 6092 | 5x66 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM5 | Y | 6092 | 5x66 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | TM5 | Y | 6092 | 5x66 | G.S1 | H | 41 | G.S1.02 |
Ionic | ICL2 | E | 6004 | - | G.H5 | H | 387 | G.H5.19 |
Polar | ICL2 | E | 6004 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | E | 6004 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | E | 6004 | - | G.H5 | H | 387 | G.H5.19 |
Polar | ICL3 | R | 6099 | - | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | ICL3 | R | 6099 | - | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL3 | F | 6096 | - | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | ICL3 | F | 6096 | - | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM3 | L | 5999 | 3x58 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL2 | N | 6002 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | N | 6002 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | N | 6002 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | C-term | I | 6299 | - | G.S2 | E | 209 | G.S2.03 |
Van-der-waals | C-term | I | 6299 | - | G.S2 | E | 209 | G.S2.03 |
Van-der-waals | TM6 | N | 6101 | 6x35 | G.H5 | L | 393 | G.H5.25 |
Polar | TM5 | Y | 6092 | 5x66 | G.hns1 | A | 39 | G.hns1.03 |
Polar | ICL2 | R | 6008 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | ICL2 | R | 6008 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Van-der-waals | ICL2 | R | 6008 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | H8 | Y | 6167 | 8x58 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | H8 | Y | 6167 | 8x58 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL2 | E | 6004 | - | G.H5 | M | 386 | G.H5.18 |
Hydrophobic | C-term | N | 6201 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | C-term | N | 6201 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | H8 | H | 6156 | 8x47 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL3 | V | 6095 | - | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL3 | V | 6095 | - | G.H5 | Q | 384 | G.H5.16 |
Polar | C-term | T | 6304 | - | G.H2 | Q | 236 | G.H2.09 |
Polar | TM3 | V | 6000 | 3x59 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM3 | V | 6000 | 3x59 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | TM3 | V | 6000 | 3x59 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM6 | I | 6108 | 6x42 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | I | 6108 | 6x42 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | C-term | L | 6296 | - | G.S2 | E | 209 | G.S2.03 |
Van-der-waals | C-term | L | 6296 | - | G.S2 | E | 209 | G.S2.03 |
Hydrophobic | C-term | I | 6262 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | C-term | L | 6265 | - | G.H2 | I | 235 | G.H2.08 |
Van-der-waals | C-term | L | 6265 | - | G.H2 | I | 235 | G.H2.08 |
Hydrophobic | TM7 | Y | 6152 | 7x57 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM7 | Y | 6152 | 7x57 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM2 | M | 5935 | 2x44 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM2 | M | 5935 | 2x44 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | C-term | K | 6197 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Polar | TM5 | H | 6081 | 5x55 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM5 | H | 6081 | 5x55 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM3 | M | 6001 | 3x60 | G.HN | K | 34 | G.HN.51 |
Hydrophobic | ICL3 | F | 6096 | - | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | ICL3 | F | 6096 | - | G.H5 | R | 385 | G.H5.17 |
Polar | TM3 | V | 5998 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | V | 5998 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | V | 5998 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | V | 5998 | 3x57 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM3 | V | 5998 | 3x57 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM5 | V | 6085 | 5x59 | G.HN | Q | 35 | G.HN.52 |
Ionic | C-term | D | 6259 | - | G.H3 | R | 280 | G.H3.16 |
Polar | C-term | D | 6259 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | C-term | D | 6259 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | TM3 | V | 5998 | 3x57 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | S | 6198 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Hydrophobic | TM3 | L | 5999 | 3x58 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL2 | H | 6005 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | ICL2 | H | 6005 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Van-der-waals | ICL2 | H | 6005 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Polar | TM2 | A | 5937 | 2x46 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM2 | A | 5937 | 2x46 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM2 | A | 5937 | 2x46 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM5 | Q | 6088 | 5x62 | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | TM5 | Q | 6088 | 5x62 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | C-term | K | 6266 | - | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | C-term | K | 6266 | - | G.H3 | W | 281 | G.H3.17 |
Polar | TM6 | N | 6101 | 6x35 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM6 | N | 6101 | 6x35 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM6 | N | 6101 | 6x35 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL2 | N | 6002 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | N | 6002 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | N | 6002 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | I | 6262 | - | G.H2 | I | 235 | G.H2.08 |
Van-der-waals | C-term | I | 6262 | - | G.H2 | I | 235 | G.H2.08 |
Polar | TM2 | A | 5938 | 2x47 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM2 | A | 5938 | 2x47 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | I | 6262 | - | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | C-term | I | 6262 | - | G.H3 | W | 281 | G.H3.17 |
Polar | ICL2 | E | 6004 | - | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL2 | E | 6004 | - | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | ICL2 | E | 6004 | - | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM5 | Y | 6092 | 5x66 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | Y | 6092 | 5x66 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | C-term | M | 6206 | - | G.h4s6 | G | 355 | G.h4s6.11 |
Hydrophobic | C-term | M | 6206 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | C-term | M | 6206 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM6 | I | 6105 | 6x39 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | I | 6105 | 6x39 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | I | 6301 | - | G.H2 | Q | 236 | G.H2.09 |
Van-der-waals | C-term | I | 6301 | - | G.H2 | Q | 236 | G.H2.09 |
Hydrophobic | C-term | F | 6258 | - | G.H3 | N | 279 | G.H3.15 |
Van-der-waals | C-term | F | 6258 | - | G.H3 | N | 279 | G.H3.15 |
Hydrophobic | TM2 | A | 5937 | 2x46 | G.H5 | L | 394 | G.H5.26 |
Polar | TM3 | M | 6001 | 3x60 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM3 | M | 6001 | 3x60 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | TM3 | M | 6001 | 3x60 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | C-term | L | 6296 | - | G.H1 | R | 61 | G.H1.09 |
Polar | TM5 | Y | 6092 | 5x66 | G.H5 | H | 387 | G.H5.19 |
Aromatic | TM5 | Y | 6092 | 5x66 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM5 | Y | 6092 | 5x66 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM5 | Y | 6092 | 5x66 | G.H5 | H | 387 | G.H5.19 |
Polar | C-term | R | 6298 | - | G.hfs2 | S | 205 | G.hfs2.06 |
Van-der-waals | C-term | R | 6298 | - | G.hfs2 | S | 205 | G.hfs2.06 |
Hydrophobic | TM2 | A | 5938 | 2x47 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM5 | Y | 6092 | 5x66 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | C-term | V | 6294 | - | G.h1ha | V | 65 | G.h1ha.01 |
Van-der-waals | C-term | V | 6294 | - | G.h1ha | V | 65 | G.h1ha.01 |
Hydrophobic | C-term | L | 6261 | - | G.H2 | R | 232 | G.H2.05 |
Hydrophobic | ICL3 | F | 6096 | - | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL3 | F | 6096 | - | G.H5 | Q | 384 | G.H5.16 |